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Fluorescent nanoparticles

Jangsun Hwang, Mintai P Hwang, Moonhyun Choi, Youngmin Seo, Yeonho Jo, Jaewoo Son, Jinkee Hong, Jonghoon Choi
Heavy metal pollution has been a problem since the advent of modern transportation, which despite efforts to curb emissions, continues to play a critical role in environmental pollution. Copper ions (Cu(2+)), in particular, are one of the more prevalent metals that have widespread detrimental ramifications. From this perspective, a simple and inexpensive method of detecting Cu(2+) at the micromolar level would be highly desirable. In this study, we use porous silicon nanoparticles (NPs), obtained via anodic etching of Si wafers, as a basis for undecylenic acid (UDA)- or acrylic acid (AA)-mediated hydrosilylation...
October 18, 2016: Scientific Reports
Singkome Tima, Siriporn Okonogi, Chadarat Ampasavate, Chad Pickens, Cory Berkland, Songyot Anuchapreeda
This study aimed at developing a curcumin (CM) nanoparticle targeted to Feline McDonough Sarcoma (FMS)-like tyrosine kinase 3 (FLT3) protein on the surface of leukemic cells and at evaluating their properties, specificity, cytotoxicity, and inhibitory effect on FLT3 protein level in FLT3-overexpressing leukemic cells, EoL-1, and MV-4-11 cells. FLT3-specific peptides were conjugated onto modified poloxamer 407 using the copper-catalyzed azide-alkyne cycloaddition reaction. The thin film hydration method was performed for FLT3-specific CM-loaded polymeric micelles (FLT3-CM-micelles) preparation...
October 14, 2016: Journal of Pharmaceutical Sciences
Young Kwang Kim, Eun Bi Kang, Sung Han Kim, Shazid Md Sharker, Beyung Youn Kong, Insik In, Kang Dae Lee, Sung Young Park
In this study, a new hydrophilic-hydrophobic transition surface was designed via visible-light-induced photocatalytic perfluorinated silica-based fluorescent carbon nanoparticles (FNPs)/TiO2. Perfluorinated silica-polydopamine hybrid FNPs (f-FNPs) were easily fabricated by carbonization in an emulsion system consisting of tetraethyl orthosilicate and dopamine, followed by the deposition of TiO2 on f-FNPs, which demonstrated the reversal from hydrophobic to hydrophilic nature during successful photocatalysis...
October 17, 2016: ACS Applied Materials & Interfaces
Sarbani Ashe, Debasis Nayak, Manisha Kumari, Bismita Nayak
Advanced glycation end-products (AGEs) resulting from non-enzymatic glycation are one of the major factors involved in diabetes and its secondary complications and diseases. This necessitates our urge to discover new compounds that may be used as potential AGEs inhibitors without affecting the normal structure and function of biomolecules. In the present study, we investigated the inhibitory effects of AgNP (silver nanoparticles) on AGEs formation as well as their inhibitory effects on glycation mediated cell toxicity via ROS production and DNA damage...
October 17, 2016: ACS Applied Materials & Interfaces
Rosemeyre A Cordeiro, Daniela Santo, Dina Farinha, Arménio Serra, Henrique Faneca, Jorge F J Coelho
Cationic polymer-based vectors have been considered a promising strategy in gene therapy area due to their inherent ability to condense genetic material and successfully transfect cells. However, they usually exhibit high cytotoxicity. In this work, it is proposed the use of a tailor-made gene carrier based on a tri-block copolymer of poly[2-(dimethylamino)ethyl methacrylate] and poly(β-amino ester) (PDMAEMA-b-PβAE-b-PDMAEMA), the influence of the PβAE length being assessed. For this purpose, three different block copolymers were prepared varying the molecular weight of this segment...
October 12, 2016: Acta Biomaterialia
Xiongwei Hu, Xiaochun Dong, Yi Lu, Jianping Qi, Weili Zhao, Wei Wu
The biological fate of nanocarriers has yet to be fully explored, mainly because of the lack of functional tools like probes to identify integral nanocarriers in the body. Understanding their in vivo fate remains as the bottleneck to the development of nanomedicines. Bioimaging results based on conventional fluorescent or radioactive probes should be judged crucially because images merely reflect bulk signals of an admixture of the nanoparticles and free probes. It is crucial to discriminate between nanocarrier-bound and free signals...
October 11, 2016: Drug Discovery Today
Prakash M Gopalakrishnan Nair, Ill Min Chung
This study examined the mechanism of toxicity in Arabidopsis thaliana seedlings to zinc oxide nanoparticles (ZnO NPs) and zinc (Zn) ions. We subjected plants to different ZnO NPs and Zn ion concentrations (0, 20, 50, 100 and 200mg/L) and analyzed resulting morphological changes, transcriptional regulation of genes involved in Zn-homeostasis, macro- and microelement homeostasis, as well as auxin regulation. Except for 20mg/L, the fresh weight and primary root length was reduced after exposure to all other concentrations of Zn ion and ZnO NP concentrations...
October 11, 2016: Science of the Total Environment
Roberto Matassa, Giuseppe Familiari, Ezio Battaglione, Concita Sibilia, Grigore Leahu, Alessandro Belardini, Iole Venditti, Laura Fontana, Ilaria Fratoddi
Today, nanochemistry research of hybrid materials growth in liquid media represents a new challenge for tailoring specific nano-sized materials directly related to the hybrid electron-optical properties. Distinctive assumptions about the origin, the growth, and the functionalization of hybrid nanoparticles have recently been proposed by scientific research to attend the different aspects of observable behaviors. Therefore, appropriate morpho-structural observation of the hybrid nanoparticles is the most important factor for controlling the chemical and physical properties...
October 14, 2016: Nanoscale
Jabadurai Jayapaul, Susanne Arns, Matt Bunker, Marek Weiler, Sandra Rutherford, Peter Comba, Fabian Kiessling
: Riboflavin (Rf) receptors bind and translocate Rf and its phosphorylated forms (e.g. flavin mononucleotide, FMN) into cells where they mediate various cellular metabolic pathways. Previously, we showed that FMN-coated ultrasmall superparamagnetic iron oxide (FLUSPIO) nanoparticles are suitable for labeling metabolically active cancer and endothelial cells in vitro. In this study, we focused on the in vivo application of FLUSPIO using prostate cancer xenografts. Size, charge, and chemical composition of FLUSPIO were evaluated...
2016: Nano Research
Mehran Kianinia, Olga Shimoni, Avi Bendavid, Andreas W Schell, Steven J Randolph, Milos Toth, Igor Aharonovich, Charlene J Lobo
Arrays of fluorescent nanoparticles are highly sought after for applications in sensing, nanophotonics and quantum communications. Here we present a simple and robust method of assembling fluorescent nanodiamonds into macroscopic arrays. Remarkably, the yield of this directed assembly process is greater than 90% and the assembled patterns withstand ultra-sonication for more than three hours. The assembly process is based on covalent bonding of carboxyl to amine functional carbon seeds and is applicable to any material, and to non-planar surfaces...
October 13, 2016: Nanoscale
Caixia Niu, Quanwei Song, Gen He, Na Na, Jin Ouyang
Optical antennas with anisotropic metal nanostructures are widely used in the field of fluorescence enhancement based on localized surface plasmons (LSPs). They overcome the intrinsic defects of low brightness of near-infrared (NIR) dyes and can be used to develop sensitive NIR sensors for bioapplications. Here, we demonstrate a novel NIR plasmon-enhanced fluorescence (PEF) system consisting of elongated gold nanobipyramids (Au NBPs) antennas, silica, and NIR dyes. Silica was chosen as the rigid spacer to regulate the distance between the metal nanostructures and dyes...
October 13, 2016: Analytical Chemistry
Chaoting Zeng, Wenting Shang, Xiaoyuan Liang, Xiao Liang, Qingshan Chen, Chongwei Chi, Yang Du, Chihua Fang, Jie Tian
To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near-infrared ray (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision...
October 12, 2016: ACS Applied Materials & Interfaces
Pingsheng Huang, Huijuan Song, Yumin Zhang, Jinjian Liu, Ju Zhang, Weiwei Wang, Jianfeng Liu, Chen Li, Deling Kong
The objective of this study was to investigate the spatiotemporal delivery of nanomedicines by an injectable, thermosensitive and nanoparticle self-aggregated hydrogel for peritumoral chemotherapy. Doxorubicin (Dox) was taken as the model medicine, which was encapsulated into poly(ε-caprolactone-co- 1,4,8-trioxa[4.6]spiro-9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co -1,4,8-trioxa[4.6]spiro-9-undecanone) (PECT) nanoparticles (PECT/Dox NPs). Macroscale hydrogel was formed by thermosensitive self-aggregation of PECT/Dox NPs in aqueous solution...
October 12, 2016: ACS Applied Materials & Interfaces
Suman Rana, Neena G Shetake, K C Barick, B N Pandey, H G Salunke, P A Hassan
The interfacial engineering of magnetic nanoparticles (MNPs) with specific functional groups or targeting ligands is important for their in vivo applications. We report here the preparation and characterization of bifunctional magnetic nanoparticles (BMNPs) which contain a carboxylic moiety for drug binding and an amine moiety for folate mediated drug targeting. BMNPs were prepared by introducing bioactive cysteine molecules onto the surface of undecenoic acid coated Fe3O4 magnetic nanoparticles (UMNPs) via a thiol-ene click reaction and then, folic acid was conjugated with these BMNPs through an EDC-NHS coupling reaction...
October 12, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Bo-Ram Lee, Ho Kyung Ko, Ju Hee Ryu, Keum Young Ahn, Young-Ho Lee, Se Jin Oh, Jin Hee Na, Tae Woo Kim, Youngro Byun, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee
Efficient delivery of tumor-specific antigens (TSAs) to lymph nodes (LNs) is essential to eliciting robust immune response for cancer immunotherapy but still remains unsolved. Herein, we evaluated the direct LN-targeting performance of four different protein nanoparticles with different size, shape, and origin [Escherichia coli DNA binding protein (DPS), Thermoplasma acidophilum proteasome (PTS), hepatitis B virus capsid (HBVC), and human ferritin heavy chain (hFTN)] in live mice, using an optical fluorescence imaging system...
October 11, 2016: Scientific Reports
Yang Yuan, H Enis Karahan, Cansu Yıldırım, Li Wei, Özgür Birer, Shengli Zhai, Raymond Lau, Yuan Chen
The chirality-selective synthesis of relatively large (diameter > 1 nm) single-walled carbon nanotubes (SWCNTs) is of great interest for a variety of practical applications, but only a few catalysts are available so far. Previous studies suggested that S (compounds) can enhance the chirality-selectivity of Co catalysts in SWCNT synthesis, however, the mechanism behind is not fully understood, and no tailorable methodology has yet been developed. Here, we demonstrate a facile approach to achieve the chirality-selective synthesis of SWCNTs by the sulfidation-based poisoning of silica-supported Co catalysts using a mixture of H2S and H2...
October 14, 2016: Nanoscale
Qianjin Li, Tripta Kamra, Lei Ye
Combining straightforward molecular imprinting with orthogonal click chemistry and accessible fluorescent dyes, a modular approach has been developed to assemble turn-on optical sensors based on fluorescence resonance energy transfer in molecularly imprinted nanoparticles.
October 6, 2016: Chemical Communications: Chem Comm
Benhua Xu, Xiaoliang Tang, Ji'an Zhou, Wanmin Chen, Haile Liu, Zhenghua Ju, Weisheng Liu
A functional amide-type pincer ligand was designed and synthesized, which could effectively capture Tb(3+) ions to form a phosphorescence complex-based chemosensor Tb-1. The chemosensor could further coordinate with Pb(2+) ions and display a turn-on phosphorescence response. This sensing process was analyzed in detail by steady-state luminescence spectroscopy, time-resolved luminescence spectroscopy, electron microscopy and dynamic light scattering, which suggest that the formation of Pb(2+)-induced hydroxide nanoclusters can adjust the optical signal of the external luminescence compound by embedment and fixation of Tb(3+) complexes...
September 16, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Christos Tserkezis, Nikolaos Stefanou, Martijn Wubs, N Asger Mortensen
Molecular spontaneous emission and fluorescence depend strongly on the emitter local environment. Plasmonic nanoparticles provide excellent templates for tailoring fluorophore emission, as they exhibit potential for both fluorescence enhancement and quenching, depending on emitter positioning in the nanoparticle vicinity. Here we explore the influence of hitherto disregarded nonclassical effects on the description of emitter-plasmon hybrids, focusing on the roles of the metal nonlocal response and especially size-dependent plasmon damping...
October 14, 2016: Nanoscale
S A Papadimitriou, M P Robin, D Ceric, R K O'Reilly, S Marino, M Resmini
Nanomaterials are emerging as strong candidates for applications in drug delivery and offer an alternative platform to modulate the differentiation and activity of neural stem cells. Herein we report the synthesis and characterization of two different classes of polymeric nanoparticles: N-isopropylacrylamide-based thermoresponsive nanogels RM1 and P(TEGA)-b-P(d,lLA)2 nano-micelles RM2. We covalently linked the nanoparticles with fluorescent tags and demonstrate their ability to be internalized and tracked in neural stem cells from the postnatal subventricular zone, without affecting their proliferation, multipotency and differentiation characteristics up to 150 μg ml(-1)...
October 6, 2016: Nanoscale
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