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Fluorescent nanoparticles

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https://www.readbyqxmd.com/read/28918472/a-reliable-protocol-for-colorimetric-determination-of-iron-oxide-nanoparticle-uptake-by-cells
#1
Daiana K Deda, Roberta M Cardoso, Mayara K Uchiyama, Christiane Pavani, Sergio H Toma, Mauricio S Baptista, Koiti Araki
Size, shape, and surface properties of superparamagnetic iron oxide nanoparticles (SPIONs) can influence their interaction with biological systems, particularly the incorporation by tumor cells and consequently the biological activity and efficiency in biomedical applications. Several strategies have been used to evaluate cellular uptake of SPIONs. While qualitative methods are generally based on microscopy techniques, quantitative assays are carried out by techniques such as inductively coupled plasma-mass spectrometry and flow cytometry...
September 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28918375/synthesis-of-fluorescent-dendrimers-with-aggregation-induced-emission-features-through-a-one-pot-multi-component-reaction-and-their-utilization-for-biological-imaging
#2
Weihua Luo, Ruming Jiang, Meiying Liu, Qing Wan, Jianwen Tian, Yuanqing Wen, Qian-Yong Cao, Junfeng Hui, Xiaoyong Zhang, Yen Wei
Hyperbranched polymers have attracted wide research attention owing to their unique topological structure, physicochemical properties and great potential for applications such asadditives, drug delivery, catalysts and nanotechnology. Among these, the polyamidoamine(PAMAM) dendrimers are some of the most important dendrimers. However, the synthesis and biomedical applications of fluorescent PAMAM dendrimers have received only limited attention. In this work, we present a rather effective and convenient approach for synthesis of fluorescent PAMAM dendrimers with aggregation-induced emission (AIE) properties through a one-pot catalyst-free Mannich reaction under rather mild experimental conditions (e...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28918028/human-dmbt1-derived-cell-penetrating-peptides-for-intracellular-sirna-delivery
#3
Martina Tuttolomondo, Cinzia Casella, Pernille Lund Hansen, Ester Polo, Luciana M Herda, Kenneth A Dawson, Henrik J Ditzel, Jan Mollenhauer
Small interfering RNA (siRNA) is a promising molecule for gene therapy, but its therapeutic administration remains problematic. Among the recently proposed vectors, cell-penetrating peptides show great promise in in vivo trials for siRNA delivery. Human protein DMBT1 (deleted in malignant brain tumor 1) is a pattern recognition molecule that interacts with polyanions and recognizes and aggregates bacteria. Taking advantage of these properties, we investigated whether specific synthetic DMBT1-derived peptides could be used to formulate nanoparticles for siRNA administration...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917946/cellular-uptake-and-intracellular-localization-of-poly-acrylic-acid-nanoparticles-in-a-rainbow-trout-oncorhynchus-mykiss-gill-epithelial-cell-line-rtgill-w1
#4
Lindsey C Felix, Van A Ortega, Greg G Goss
The ever-growing production of engineered nanoparticles (NPs) for use in many agricultural, commercial, consumer, and industrial applications will lead to their accidental or intentional release into the environment. Potential routes of environmental exposure include manufacturing or transport spills, disposal of NP-containing products down the drain and/or in landfills, as well as direct usage on agricultural land. Therefore, NPs will inevitably contaminate aquatic environments and interact with resident organisms...
September 7, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28917853/preparation-and-biological-activity-studies-of-resveratrol-loaded-ionically-cross-linked-chitosan-tpp-nanoparticles
#5
Jie Wu, Yaping Wang, Hao Yang, Xiangyu Liu, Zhong Lu
Nanoparticles with size range of 10-500nm can be efficiently delivered into cancer cells by the Enhanced Permeability and Retention (EPR) effect. Here, we prepared resveratrol (Res) loaded chitosan (CS) nanoparticles with the size of 172-217nm by an ionic cross-linking method, with sodium tripolyphosphate (TPP) as the cross-linking agent, to improve the stability, solubility and tumors targeting of the natural anti-cancer drug Res. The prepared Res loaded CS-TPP nanoparticles presented long-term storage stability and UV light stability...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917774/fret-on-lateral-flow-test-strip-to-enhance-sensitivity-for-detecting-cancer-biomarker
#6
Jidong Wang, Fengjing Cao, Songliang He, Yong Xia, Xinyu Liu, Wenxiao Jiang, Yangyang Yu, Huisheng Zhang, Wenwen Chen
Fluorescence resonance energy transfer (FRET) between fluorescein isothiocyanate (FITC) and gold nanoparticles (Au NPs) is introduced in the lateral flow strip to detect cancer biomarker CEA with the color and fluorescence dual-readout. Anti-CEA monoclonal antibody coated Au NPs were on the conjugate pad and FITC labelled antibody (FITC-Ab) for CEA was coated on the test line. All the reagents were general in the lateral flow strip or commercially available and no new materials or technique were involved, which make our proposal a more universal method and easier to operate...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917752/facilely-self-assembled-magnetic-nanoparticles-aptamer-carbon-dots-nanocomposites-for-highly-sensitive-up-conversion-fluorescence-turn-on-detection-of-tetrodotoxin
#7
Hui Jin, Rijun Gui, Jie Sun, Yanfeng Wang
In this work, magnetic Fe3O4 nanoparticles (NPs) were modified with aptamer of tetrodotoxin (TTX) to form Fe3O4/aptamer complex. The self-assembling of carbon dots (CDs) and the aptamer generated Fe3O4/aptamer/CDs nanocomposites. The nanocomposites exhibited down-conversion fluorescence and up-conversion fluorescence (UCF) emissions simultaneously. When excited at a wavelength of 780nm, the UCF (peaked at 475nm) of nanocomposites increased regularly with the increase of TTX concentration [TTX]. In the [TTX] range from 0...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917502/fluorescence-and-magnetic-nanocomposite-fe3o4-sio2-au-mnps-as-peroxidase-mimetics-for-glucose-detection
#8
Shajie Luo, Yaqin Liu, Hanbing Rao, Yanying Wang, Xianxiang Wang
In this paper, multifunction nanoparticles (MNPs), Fe3O4@SiO2@Au MNPs, with properties of superparamagnetism, fluorescence and peroxidase-like catalytic activity were synthesized in the aqueous phase. The synthesized composites were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), powder diffraction (XRD), Fourier translation infrared spectrum (FT-IR) and fluorometer. The results show that the multifunctional nanomaterials have good magnetic and fluorescence properties...
September 13, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28916966/evaluation-of-in-vitro-efficacy-of-docetaxel-loaded-calcium-carbonate-aragonite-nanoparticles-dtx-caco3np-on-4t1-mouse-breast-cancer-cell-line
#9
Nahidah Ibrahim Hammadi, Yusuf Abba, Mohd Noor Mohd Hezmee, Intan Shameha Abdul Razak, Aminu Umar Kura, Zuki Abu Bakar Zakaria
Cockle shell-derived calcium carbonate nanoparticles have shown promising potentials as slow drug-releasing compounds in cancer chemotherapy. In this study, we evaluated the in vitro efficacy of docetaxel (DTX)-loaded CaCO3NP on 4T1 cell line. This was achieved by evaluating the following: cytotoxicity using MTT assay, fluorescence imaging, apoptosis with Annexin V assay, cell cycle analysis, scanning (SEM) and transmission electron microscopy (TEM), and scratch assay. Based on the results, DTX-CaCO3NP with a DTX concentration of 0...
September 15, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28916504/going-skin-deep-a-direct-comparison-of-penetration-potential-of-lipid-based-nanovesicles-on-the-isolated-perfused-human-skin-flap-model
#10
Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Nataša Škalko-Basnet
Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). Two fluorescent markers, calcein (hydrophilic) or rhodamine (lipophilic), were incorporated individually in the three nanosystems...
September 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28916319/inhibition-of-growth-and-biofilm-formation-of-clinical-bacterial-isolates-by-nio-nanoparticles-synthesized-from-eucalyptus-globulus-plants
#11
Samia Saleem, Bilal Ahmed, Mohammad Saghir Khan, Majed Al-Shaeri, Javed Musarrat
Nanotechnology based therapeutics has emerged as a promising approach for augmenting the activity of existing antimicrobials due to the unique physical and chemical properties of nanoparticles (NPs). Nickel oxide nanoparticles (NiO-NPs) have been suggested as prospective antibacterial and antitumor agent. In this study, NiO-NPs have been synthesized by a green approach using Eucalyptus globulus leaf extract and assessed for their bactericidal activity. The morphology and purity of synthesized NiO-NPs determined through various spectroscopic techniques like UV-Visible, FT-IR, XRD, EDX and electron microscopy differed considerably...
September 12, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28916107/genetically-functionalized-ferritin-nanoparticles-with-a-high-affinity-protein-binder-for-immunoassay-and-imaging
#12
Jong-Won Kim, Woosung Heu, Sukyo Jeong, Hak-Sung Kim
Molecular detection of target molecules with high sensitivity and specificity is of great significance in bio and medical sciences. Here, we present genetically functionalized ferritin nanoparticles with a high-affinity protein binder, and their utility as a signal generator in a variety of immunoassays and imaging. As a high-affinity protein binder, human IgG-specific repebody, which is composed of LRR (Leucine-rich repeat) modules, was used. The repebody was genetically fused to the N-terminal heavy-chain ferritin, and the resulting subunits were self-assembled to the repebody-ferritin nanoparticles composed of 24 subunits...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916106/silver-nanoclusters-capped-silica-nanoparticles-as-a-ratiometric-photoluminescence-nanosensor-for-the-selective-detection-of-i-and-s-2
#13
Xinan Huang, Sohail Anjum Shahzad, Yongxin Li, Yunyi Zhang, Lijia Sang, Huipeng Zhou, Hong Jiang, Kenneth Kam-Wing Lo, Cong Yu
A novel and efficient approach has been established for the synthesis of silver nanoclusters capped silica nanoparticles (SiO2@AgNCs). These nanoclusters (AgNCs) capped silica nanoparticles were utilized as a novel ratiometric photoluminescence (PL) nanosensor for extremely sensitive and selective detection of I(-) and S(2-) ions. The AgNCs were prepared in situ on the silica nanoparticles through polyethyleneimine (PEI) template approach. While dual PL emissions of AgNCs (at 500 nm) and luminescent silica nanoparticles (at 602 nm) formed the basis for the ratiometric sensing...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28916035/sensitive-prostate-specific-antigen-quantification-using-dihydrolipoic-acid-surface-functionalized-phosphorescent-quantum-dots
#14
Marta García-Cortés, María Teresa Fernández-Argüelles, José M Costa-Fernández, Alfredo Sanz-Medel
Herein, high-quality Mn-doped ZnS quantum dots (QDs) have been synthesized using a facile approach directly in aqueous media. The surface of the obtained QDs was further modified by cap-exchange of the native cysteine shell with dihydrolipoic acid (DHLA) ligands resulting in nanocrystals with high water-stability having an intense phosphorescent signal. Covalent bioconjugation of the DHLA-coated nanoparticles with an anti-IgG antibody was then carried out. Interestingly the QD immunoprobe (QD-labelled antibodies) maintained an intense phosphorescence emission, without any significant spectral-shift (as compared to the free QDs)...
September 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915940/accurate-and-reliable-quantification-of-the-protein-surface-coverage-on-protein-functionalized-nanoparticles
#15
Siyao Liu, Jeannie Horak, Markus Höldrich, Michael Lämmerhofer
The ability to accurately quantify the protein coverage on nanoparticles is critical for assessing the quality of the surface chemistry and the success of the functionalization process of protein-nanoparticle conjugates. Surface coverage determination is therefore an integral part in the quality control of protein-modified nanoparticles in industrial nanotechnology. In this work, a novel and conventional method was established for direct quantification of the protein surface coverage on metallic nanoparticles...
October 9, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28915410/aiegens-for-biological-process-monitoring-and-disease-theranostics
#16
REVIEW
Xinggui Gu, Ryan T K Kwok, Jacky W Y Lam, Ben Zhong Tang
Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect...
September 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28915384/supramolecular-nano-sniffers-for-ultrasensitive-detection-of-formaldehyde
#17
Uchangi Satyaprasad Akshath, Praveena Bhatt
Supramolecular nanoparticle hybrids for biosensing of analytes have been a major focus due to their tunable optical and surface properties. Quantum dots-Gold nanoparticle (QDs-GNP) based FRET probes involving turn on/off principles have gained immense interest due to their specificity and sensitivity. Recent focus is on applying these supramolecular hybrids for enzyme operated biosensors that can specifically turn-on fluorescence induced by co-factor or product formed from enzymatic reaction. The present study focuses on locking and unlocking the interaction between QD-GNP pair leading to differential fluorescent properties...
September 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28915005/a-novel-type-of-aqueous-dispersible-ultrathin-layered-double-hydroxide-nanosheets-for-in-vivo-bioimaging-and-drug-delivery
#18
Li Yan, Mengjiao Zhou, Xiujuan Zhang, Longbiao Huang, Wei Chen, Vellaisamy A L Roy, WenJun Zhang, Xianfeng Chen
Layered double hydroxide (LDH) nanoparticles have been widely used for various biomedical applications. However, because of the difficulty of surface functionalization of LDH nanoparticles, the systemic administration of these nanomaterials for in vivo therapy remains a bottleneck. In this work, we develop a novel type of aqueous dispersible two dimensional ultrathin LDH nanosheets with a size of about 50 nm and a thickness of about 1.4 to 4 nm. We are able to covalently attach positively charged Rhodamine B fluorescent molecules to the nanosheets and the nanohybrid retains strong fluorescence in liquid and even dry powder form...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28914481/boron-and-nitrogen-co-doped-carbon-dots-as-a-sensitive-fluorescent-probe-for-the-detection-of-curcumin
#19
Wei Bian, Xuan Wang, Yakun Wang, Haifen Yang, Jialin Huang, Zongwei Cai, Martin M F Choi
In this present study, a fluorescent probe was developed to detect curcumin, which is derived from the rhizomes of the turmeric. We used a simple and economical way to synthesize boron and nitrogen co-doped carbon dots (BNCDs) by microwave heating. The maximum emission wavelength of the BNCDs was 450 nm at an excitation wavelength of 360 nm. The as-prepared BNCDs were characterized by multiple analytical techniques such as transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and infrared spectroscopy...
September 15, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28913948/synthesis-of-size-tunable-hollow-polypyrrole-nanostructures-and-their-assembly-into-folate-targeting-and-ph-responsive-anti-cancer-drug-delivery
#20
Jian Chen, Xiufang Li, Yanhua Sun, Yuwei Hu, Yulong Peng, Yimin Li, Gang Yin, Hui Liu, Jiangfeng Xu, Shian Zhong
Chemotherapeutic drugs currently used in clinical settings have a high toxicity, low specificity, and short half-life. Herein, polypyrrole (PPy)-based anticancer drug nanocapsules were prepared by tailoring the nanoparticle size with a template method, controlling drug release by aromatic imine, increasing nanoparticle stability through PEGylation, and improving tumor cell selectivity via folate (FA) mediation. Nanoparticles were characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
September 15, 2017: Chemistry: a European Journal
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