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https://www.readbyqxmd.com/read/28110411/development-of-the-siope-dipg-network-registry-and-imaging-repository-a-collaborative-effort-to-optimize-research-into-a-rare-and-lethal-disease
#1
Sophie E M Veldhuijzen van Zanten, Joshua Baugh, Brooklyn Chaney, Dennis De Jongh, Esther Sanchez Aliaga, Frederik Barkhof, Johan Noltes, Ruben De Wolf, Jet Van Dijk, Antonio Cannarozzo, Carin M Damen-Korbijn, Jan A Lieverst, Niclas Colditz, Marion Hoffmann, Monika Warmuth-Metz, Brigitte Bison, David T W Jones, Dominik Sturm, Gerrit H Gielen, Chris Jones, Esther Hulleman, Raphael Calmon, David Castel, Pascale Varlet, Géraldine Giraud, Irene Slavc, Stefaan Van Gool, Sandra Jacobs, Filip Jadrijevic-Cvrlje, David Sumerauer, Karsten Nysom, Virve Pentikainen, Sanna-Maria Kivivuori, Pierre Leblond, Natasha Entz-Werle, Andre O von Bueren, Antonis Kattamis, Darren R Hargrave, Péter Hauser, Miklos Garami, Halldora K Thorarinsdottir, Jane Pears, Lorenza Gandola, Giedre Rutkauskiene, Geert O Janssens, Ingrid K Torsvik, Marta Perek-Polnik, Maria J Gil-da-Costa, Olga Zheludkova, Liudmila Shats, Ladislav Deak, Lidija Kitanovski, Ofelia Cruz, Andres Morales La Madrid, Stefan Holm, Nicolas Gerber, Rejin Kebudi, Richard Grundy, Enrique Lopez-Aguilar, Marta Zapata-Tarres, John Emmerik, Tim Hayden, Simon Bailey, Veronica Biassoni, Maura Massimino, Jacques Grill, William P Vandertop, Gertjan J L Kaspers, Maryam Fouladi, Christof M Kramm, Dannis G van Vuurden
Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In a first step towards collaboration, in 2011, a network of biologists and clinicians working in the field of DIPG was established within the European Society for Paediatric Oncology (SIOPE) Brain Tumour Group: the SIOPE DIPG Network...
January 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28110379/-they-are-talking-about-me-but-not-with-me-a-focus-group-study-to-explore-the-patient-perspective-on-interprofessional-team-meetings-in-primary-care
#2
Jerôme Jean Jacques van Dongen, Maarten de Wit, Hester Wilhelmina Henrica Smeets, Esther Stoffers, Marloes Amantia van Bokhoven, Ramon Daniëls
BACKGROUND: The number of people with multiple chronic conditions receiving primary care services is growing. To deal with their increasingly complex health care demands, professionals from different disciplines need to collaborate. Interprofessional team (IPT) meetings are becoming more popular. Several studies describe important factors related to conducting IPT meetings, mostly from a professional perspective. However, in the light of patient-centeredness, it is valuable to also explore the patients' perspective...
January 21, 2017: Patient
https://www.readbyqxmd.com/read/28110113/a-photo-voice-perspective-on-factors-contributing-to-the-resilience-of-hiv-positive-yoruba-adolescent-girls-in-nigeria
#3
Catherine O Adegoke, Miemsie G Steyn
There is a growing discourse worldwide on the impact of the Human Immunodeficiency Virus (HIV) on "at risk youths". In response, five HIV-positive Nigerian adolescent girls were qualitatively investigated in collaboration with a non-governmental organisation (NGO) in Ibadan, an urban settlement in Nigeria in 2013. Using a secondary data analysis from a photo voice component of the research, combined with narratives, we show that participants possess the capacity to overcome their adversities from the effects of HIV infection and remain resilient...
January 18, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28110083/preconditioning-in-neuroprotection-from-hypoxia-to-ischemia
#4
REVIEW
Sijie Li, Adam Hafeez, Fatima Noorulla, Xiaokun Geng, Guo Shao, Changhong Ren, Guowei Lu, Heng Zhao, Yuchuan Ding, Xunming Ji
Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon has been termed hypoxic or ischemic preconditioning (HPC or IPC) and is well established in the heart and the brain. This review aims to discuss HPC and IPC with respect to their historical development and advancements in our understanding of the neurochemical basis for their neuroprotective role. Through decades of collaborative research and studies of HPC and IPC in other organ systems, our understanding of HPC and IPC-induced neuroprotection has expanded to include: early- (phosphorylation targets, transporter regulation, interfering RNA) and late- (regulation of genes like EPO, VEGF, and iNOS) phase changes, regulators of programmed cell death, members of metabolic pathways, receptor modulators, and many other novel targets...
January 18, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28110007/human-health-and-ecological-assessment-programs-for-hebei-spirit-oil-spill-accident-of-2007-status-lessons-and-future-challenges
#5
Dawoon Jung, Jung-Ah Kim, Myung-Sook Park, Un Hyuk Yim, Kyungho Choi
Hebei Spirit oil spill (HSOS) of December 2007 is one of the worst oil spill accidents that occurred in Yellow Sea. The affected coastline along the west coast of Korean Peninsula hosts one of the largest tidal flats worldwide, and is home to tens of thousands of human residents. Based on nation-wide concerns on ecosystem damages and adverse human health effects, two separate surveillance programs on ecosystem and human health were initiated: a 10-year follow-up program by Ministry of Oceans and Fisheries to assess ecological impacts of the oil spill, and an exposure and health effect assessment program by Ministry of Environment for the residents of Taean and its vicinity...
January 2, 2017: Chemosphere
https://www.readbyqxmd.com/read/28109951/a-cognitive-approach-for-design-of-a-multimedia-informed-consent-video-and-website-in-pediatric-research
#6
Holly Antal, H Timothy Bunnell, Suzanne M McCahan, Chris Pennington, Tim Wysocki, Kathryn Blake
OBJECTIVE: Poor participant comprehension of research procedures following the conventional face-to-face consent process for biomedical research is common. We describe the development of a multimedia informed consent video and website that incorporates cognitive strategies to enhance comprehension of study related material directed to parents and adolescents. MATERIALS AND METHODS: A multidisciplinary team was assembled for development of the video and website that included human subjects professionals; psychologist researchers; institutional video and web developers; bioinformaticians and programmers; and parent and adolescent stakeholders...
January 18, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28109708/bordetella-pertussis-infection-in-children-with-severe-pneumonia-philippines-2012-2015
#7
Alexander Sadiasa, Mariko Saito-Obata, Clyde Dapat
A case-comparison study was conducted based on an observational study of severe pneumonia among hospitalized children in the Philippines. The children, from 8days to 13years old and hospitalized with clinical diagnosis of severe or very severe pneumonia from August 2012 to February 2015, were recruited. Nasopharyngeal swabs were collected from 1152 cases and B. pertussis were detected from 34 cases by PCR. Pertussis-positive cases were more likely to have no fever, more than one week of coughing and breathing difficulty, decreased breathing sounds, and central cyanosis than pertussis- negative cases...
January 18, 2017: Vaccine
https://www.readbyqxmd.com/read/28109689/-intensity-of-interprofessional-collaboration-among-intensive-care-nurses-at-a-tertiary-hospital
#8
G Serrano-Gemes, M Rich-Ruiz
OBJECTIVES: To measure the intensity of interprofessional collaboration (IPC) in nurses of an intensive care unit (ICU) at a tertiary hospital, to check differences between the dimensions of the Intensity of Interprofessional Collaboration Questionnaire, and to identify the influence of personal variables. METHOD: A cross-sectional descriptive study was conducted with 63 intensive care nurses selected by simple random sampling. Explanatory variables: age, sex, years of experience in nursing, years of experience in critical care, workday type and work shift type; variable of outcome: IPC...
January 18, 2017: Enfermería Intensiva
https://www.readbyqxmd.com/read/28109632/the-american-college-of-radiology-and-the-american-brachytherapy-society-practice-parameter-for-transperineal-permanent-brachytherapy-of-prostate-cancer
#9
Nathan H J Bittner, Peter F Orio, Gregory S Merrick, Bradley R Prestidge, Alan Charles Hartford, Seth A Rosenthal
Transperineal permanent brachytherapy is a safe and effective treatment option for patients with organ-confined prostate cancer. Careful adherence to established brachytherapy standards has been shown to improve the likelihood of procedural success and reduce the incidence of treatment-related morbidity. A collaborative effort of the American College of Radiology (ACR) and the American Brachytherapy Society (ABS) has produced practice parameters for LDR prostate brachytherapy. These practice parameters define the qualifications and responsibilities of all the involved personnel, including the radiation oncologist, physicist and dosimetrist...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/28109182/are-home-visits-an-effective-method-for-diabetes-management-a-quantitative-systematic-review-and-meta-analysis
#10
Lin Han, Yuxia Ma, Suhong Wei, Jinhui Tian, Xiaochun Yang, Xiping Shen, Jun Zhang, Yuexian Shi
AIMS: Previous reviews have revealed uncertainty regarding the effectiveness of home visit interventions for managing diabetes. Therefore, we performed a quantitative systematic review and meta-analysis to evaluate the effects of home visit interventions among patients with diabetes. METHODS: We searched various electronic databases (PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, Wanfang, and Chinese scientific full-text databases) from their inception until March 2016...
January 21, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28108993/experience-from-a-multi-country-initiative-to-improve-the-monitoring-of-selected-reproductive-health-indicators-in-africa
#11
Maria Barreix, Özge Tunçalp, Namuunda Mutombo, Ayotunde A Adegboyega, Lale Say
Universal access to sexual and reproductive health remains part of the unfinished business of global development in the Africa. To achieve it, health interventions should be monitored using programmatic indicators. WHO's Strengthening Measurement of Reproductive Health Indicators in Africa initiative, implemented in Ghana, Nigeria, Kenya, Uganda, and Zimbabwe, aimed to improve national information systems for routine monitoring of reproductive health indicators. Participating countries developed action plans employing a two-pronged strategy: (1) revising, standardizing, and harmonizing existing information-system reproductive health indicators; and (2) building data-collection capacity through training and supervision at select pilot sites...
January 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28108952/transcriptional-regulators-dictate-innate-lymphoid-cell-fates
#12
REVIEW
Chao Zhong, Jinfang Zhu
Research on innate lymphoid cells (ILC) has recently been a fast paced topic of immunological research. As ILCs are able to produce signature Th cytokine, ILCs have garnered considerable attention and have been described to represent the innate counterpart of the CD4(+) T helper (Th) cells. The development and function of ILCs are precisely regulated by a network of crucial transcription factors, which are also involved in the development or differentiation of conventional natural killer (cNK) cells and T cells...
January 20, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28108821/the-relationship-between-patient-activation-confidence-to-self-manage-side-effects-and-adherence-to-oral-oncolytics-a-pilot-study-with-michigan-oncology-practices
#13
Teresa M Salgado, Emily Mackler, Jane A Severson, Jamie Lindsay, Peter Batra, Laura Petersen, Karen B Farris
PURPOSE: The Michigan Oncology Quality Consortium (MOQC) is a continuous quality improvement collaborative seeking to improve oncology care in Michigan, including for patients taking oral chemotherapy. The aim of this study was to assess the relationship between patient activation, confidence to self-manage side effects, and adherence to oral oncolytics to inform future oncology care. METHODS: A multicenter cross-sectional observational study was conducted using an online survey to examine patient activation (patient activation measure, PAM), health literacy, symptom burden (Edmonton Symptom Assessment System, ESAS), confidence to self-manage side effects (fatigue, nausea, and diarrhea), and adherence to oral oncolytics...
January 20, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28108798/augmented-perineal-urethrostomy-using-a-dorsal-buccal-mucosal-graft-bi-institutional-study
#14
Jessica DeLong, Kurt McCammon, Leandro Capiel, Augustín Rovegno, Jeremy B Tonkin, Gerald Jordan, Ramón Virasoro
PURPOSE: To present our technique and outcomes for perineal urethrostomy augmented with a dorsal onlay buccal mucosa graft (BMG). Results from initial series and collaboration from an international center are included. METHODS: A retrospective chart review of all adult patients who underwent urethral reconstruction with perineal urethrostomy utilizing a buccal mucosal graft between January 1, 2002 and January 1, 2013 was performed. All surgeries were performed by three surgeons using the same technique (GHJ, KAM, and RV)...
January 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28108686/use-of-mechanical-insufflation-exsufflation-devices-for-airway-clearance-in-subjects-with-neuromuscular-disease
#15
REVIEW
Catherine Auger, Vanessa Hernando, Hubert Galmiche
The aim of this systematic review is to examine the benefit/risk ratio of the use of mechanical insufflation-exsufflation (MI-E) devices for airway clearance in patients with neuromuscular diseases. A search was conducted for relevant studies in MEDLINE, the Cochrane Library, and the Health Technology Assessment Database using the main key words: cough, airway clearance, in-exsufflation. The search limits were studies published in English and French between 1970 and 2014 (literature watch until December 2015)...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28108676/can-work-make-you-mentally-ill-a-systematic-meta-review-of-work-related-risk-factors-for-common-mental-health-problems
#16
REVIEW
Samuel B Harvey, Matthew Modini, Sadhbh Joyce, Josie S Milligan-Saville, Leona Tan, Arnstein Mykletun, Richard A Bryant, Helen Christensen, Philip B Mitchell
It has been suggested that certain types of work may increase the risk of common mental disorders, but the exact nature of the relationship has been contentious. The aim of this paper is to conduct the first comprehensive systematic meta-review of the evidence linking work to the development of common mental health problems, specifically depression, anxiety and/or work-related stress and to consider how the risk factors identified may relate to each other. MEDLINE, PsychInfo, Embase, the Cochrane Collaboration and grey literature databases were systematically searched for review articles that examined work-based risk factors for common mental health problems...
January 20, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28108265/palliative-care-and-parkinson-s-disease-meeting-summary-and-recommendations-for-clinical-research
#17
REVIEW
Benzi M Kluger, Siobhán Fox, Suzanne Timmons, Maya Katz, Nicholas B Galifianakis, Indu Subramanian, Julie H Carter, Miriam J Johnson, Edward W Richfield, David Bekelman, Jean S Kutner, Janis Miyasaki
INTRODUCTION: Palliative care is an approach to caring for patients and families affected by serious illnesses that focuses on the relief of suffering through the management of medical symptoms, psychosocial issues, advance care planning and spiritual wellbeing. Over the past decade there has been an emerging clinical and research interest in the application of palliative care approaches to Parkinson's disease (PD) and outpatient palliative care services are now offered by several movement disorders centers...
January 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28108166/predictive-performance-of-different-kidney-function-estimation-equations-in-lung-transplant-patients
#18
Dov A Degen, Jyotsna Janardan, Katherine A Barraclough, Hans G Schneider, Thomas Barber, Howard Barton, Gregory Snell, Bronwyn Levvey, Rowan G Walker
BACKGROUND: There has been limited examination of the performance of glomerular filtration rate estimation (eGFR) equations in lung transplant populations. This study aimed to compare the performance of serum creatinine and cystatin C based eGFR equations with Tc-99m diethylenetriaminepentaacetic acid (DTPA) GFR measurements in individuals with end-stage lung disease, either prior to, or following, lung transplantation. METHODS: In this prospective observational study, participants underwent GFR measurements with Tc-99m Pentetate...
January 17, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28108154/collaborative-design-of-a-health-care-experience-survey-for-persons-with-disability
#19
Lisa I Iezzoni, Holly Matulewicz, Sarah A Marsella, Kimberley S Warsett, Dennis Heaphy, Karen Donelan
BACKGROUND: When assessing results of health care delivery system reforms targeting persons with disability, quality metrics must reflect the experiences and perspectives of this population. OBJECTIVE: For persons with disability and researchers to develop collaboratively a survey that addresses critical quality questions about a new Massachusetts health care program for persons with disability dually-eligible for Medicare and Medicaid. METHODS: Persons with significant physical disability or serious mental health diagnoses participated fully in all research activities, including co-directing the study, co-moderating focus groups, performing qualitative analyses, specifying survey topics, cognitive interviewing, and refining survey language...
January 8, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28108127/g-enome-wide-association-study-in-takotsubo-syndrome-preliminary-results-and-future-directions
#20
Ingo Eitel, Christian Moeller, Matthias Munz, Thomas Stiermaier, Thomas Meitinger, Holger Thiele, Jeanette Erdmann
BACKGROUND: Takotsubo syndrome (TS) is an acute non-ischemic cardiomyopathy characterized by transient regional systolic dysfunction of the left and/or right ventricle with still unknown etiology. The aim of the current study was to conduct for the first time a genome-wide association study (GWAS) in a cohort of TS patients to identify potential genetic risk variants. METHODS: This single-center study was conducted at the University Heart Center Lübeck from 2008 to 2016...
January 15, 2017: International Journal of Cardiology
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