Carlo Alberto Cesaroni, Giulia Pisanò, Gabriele Trimarchi, Stefano Giuseppe Caraffi, Giulia Scandolo, Martina Gnazzo, Daniele Frattini, Carlotta Spagnoli, Susanna Rizzi, Claudia Dittadi, Giulia Sigona, Livia Garavelli, Carlo Fusco
Autosomal recessive spinocerebellar ataxia 13 (SCAR13) is a neurological disease characterized by psychomotor delay, mild to profound intellectual disability with poor or absent language, nystagmus, stance ataxia, and, if walking is acquired, gait ataxia. Epilepsy and polyneuropathy have also been documented in some patients. Cerebellar atrophy and/or ventriculomegaly may be present on brain MRI. SCAR13 is caused by pathogenic variants in the GRM1 gene encoding the metabotropic receptor of glutamate type 1 (mGlur1), which is highly expressed in Purkinje cerebellar cells, where it plays a fundamental role in cerebellar development...
October 13, 2023: Cerebellum