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https://www.readbyqxmd.com/read/29908474/early-warnings-for-suicide-attempt-among-chinese-rural-population
#1
Juncheng Lyu, Yingying Wang, Hong Shi, Jie Zhang
OBJECTIVE: This study was to explore the main influencing factors of attempted suicide and establish an early warning model, so as to put forward prevention strategies for attempted suicide. METHOD: Data came from a large-scale case-control epidemiological survey. A sample of 659 serious suicide attempters was randomly recruited from 13 rural counties in China. Each case was matched by a community control for gender, age, and residence location. Face to face interviews were conducted for all the cases and controls with the same structured questionnaire...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29908370/gender-differences-in-patients-with-brugada-syndrome-and-arrhythmic-events-data-from-a-survey-on-arrhythmic-events-in-678-patients
#2
Anat Milman, Jean-Baptiste Gourraud, Antoine Andorin, Pieter G Postema, Frederic Sacher, Philippe Mabo, Giulio Conte, Carla Giustetto, Georgia Sarquella-Brugada, Aviram Hochstadt, Sung-Hwan Kim, Jimmy Jm Juang, Shingo Maeda, Yoshihide Takahashi, Tsukasa Kamakura, Takeshi Aiba, Eran Leshem, Yoav Michowitz, Michael Rahkovich, Yuka Mizusawa, Elena Arbelo, Zhengrong Huang, Isabelle Denjoy, Yanushi D Wijeyeratne, Carlo Napolitano, Ramon Brugada, Ruben Casado-Arroyo, Jean Champagne, Leonardo Calo, Jacob Tfelt-Hansen, Silvia G Priori, Masahiko Takagi, Christian Veltmann, Pietro Delise, Domenico Corrado, Elijah R Behr, Fiorenzo Gaita, Gan-Xin Yan, Josep Brugada, Antoine Leenhardt, Arthur A M Wilde, Pedro Brugada, Kengo F Kusano, Kenzo Hirao, Gi-Byoung Nam, Vincent Probst, Bernard Belhassen
BACKGROUND: There is limited information on gender differences in patients with Brugada syndrome (BrS) who experienced arrhythmic events (AEs). OBJECTIVES: To compare clinical, electrocardiographic (ECG), electrophysiologic (EP) and genetic characteristics between males and females in BrS-patients with their first AE. METHODS: The multicenter Survey on AE in BrS (SABRUS) collected data on first AE in 678 BrS-patients including 619 (91.3%) males and 59 (8...
June 13, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29908361/incidence-of-upper-and-lower-gastrointestinal-bleeding-in-new-users-of-low-dose-aspirin
#3
Lucía Cea Soriano, Angel Lanas, Montse Soriano-Gabarró, Luis A García Rodríguez
BACKGROUND & AIMS: There are few data on the incidence of upper and lower gastrointestinal bleeding (UGIB and LGIB) from observational studies of low-dose aspirin users. We aimed to estimate incidence rates of UGIB and LGIB in a large cohort of new users of low-dose aspirin in the United Kingdom, with sub-analyses of hospitalization status and fatalities. METHODS: We performed a population-based study of 199,079 new users of low-dose aspirin (median age, 64...
June 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29908353/the-impact-of-prenatal-diagnosis-on-congenital-anomaly-outcomes-data-from-1997-to-2016
#4
REVIEW
Paula Braz, Ausenda Machado, Carlos Matias Dias
The term prenatal diagnosis comprises a variety of techniques aimed to determine the health and condition of the embryo or foetus. Its main goal is to identify at an early stage of the pregnancy, if possible, malformations or other conditions that could increase the risk of a negative outcome in the pregnancy. The aim of this study was to assess the impact of prenatal diagnosis in Portugal in pregnancies with congenital anomalies. A cross sectional study was implemented using data for the years 1997-2016 from the Portuguese registry of congenital anomalies (RENAC), a population-based registry that follows EUROCAT guidelines...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908311/longitudinal-study-of-neonatal-brain-tissue-volumes-in-preterm-infants-and-their-ability-to-predict-neurodevelopmental-outcome
#5
REVIEW
L Gui, S Loukas, F Lazeyras, P S Hüppi, D E Meskaldji, C Borradori Tolsa
Premature birth has been associated with poor neurodevelopmental outcomes. However, the relation between such outcomes and brain growth in the neonatal period has not yet been fully elucidated. This study investigates longitudinal brain development between birth and term-equivalent age (TEA) by quantitative imaging in a cohort of premature infants born between 26 and 36 weeks gestational age (GA), to provide insight into the relation of brain growth with later neurodevelopmental outcomes. Longitudinal T2-weighted magnetic resonance images (MRI) of 84 prematurely born infants acquired shortly after birth and TEA were automatically segmented into cortical gray matter (CGM), unmyelinated white matter (UWM), subcortical gray matter (SGM), cerebellum (CB) and cerebrospinal fluid (CSF)...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29908098/modelling-the-population-effectiveness-of-the-national-seasonal-influenza-vaccination-programme-in-scotland-the-impact-of-targeting-all-individuals-aged-65-years-and-over-flu-vaccination-programme-effectiveness
#6
Stephen Corson, Chris Robertson, Arlene Reynolds, Jim McMenamin
BACKGROUND: For the last 17 years, the UK has employed a routine influenza vaccination programme with the aim of reducing the spread of seasonal influenza. In mid-2000, the programme moved from a purely risk-based approach to a risk and age group targeted approach with all those aged 65+ years being included. To date, there has been no assessment of the population effectiveness of this age targeted policy in Scotland. OBJECTIVES: Statistical modelling techniques were used to determine what impact the routine vaccination of those aged 65+ years has had on influenza related morbidity and mortality in Scotland...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29908025/seroprevalence-and-social-determinants-of-varicella-in-turkey
#7
Can Hüseyin Hekimoğlu, Özgen Alpay Özbek, Mestan Emek, Mehmet Ali Öktem, Galip Köroğlu, Mustafa Sertel, Sevin Özdeniz, Ali Ceylan, Ayla Açikgöz, Belgin Ünal
Background: In Turkey, varicella vaccine was introduced into routine childhood immunization in 2013, with a single dose administered to children aged 12 months. However, there is limited information on the morbidity (incidence and seroprevalence), mortality and burden of disease of varicella in the overall Turkish population. Aim: To determine varicella seroprevalence and its social determinants in Manisa Province, Turkey in children aged > 2 years before single-dose varicella vaccination was introduced in 2013...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29908020/screening-for-dysglycaemia-using-anthropometric-indices-in-an-adult-population-in-oman
#8
Shyam Sundar Ganguly, Kamalesh Sarkar, Samir Al-Adawi, Abdul Aziz Al-Mahrezi
Background: A previous community-based cross-sectional survey conducted in a semi-urban community revealed that 44% of people aged 18+ years manifest dysglycaemia, which appears to echo the national trend. There is lack of studies examining the role of anthropometric indices in people with dysglycaemia. Aim: We explored the screening ability of anthropometric indices, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) to detect dysglycaemia in the adult Omani population based on a community-based survey conducted in 2005...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29907942/distribution-of-21-gene-recurrence-scores-in-male-breast-cancer-in-the-united-states
#9
Ariella M Altman, Scott Kizy, Jianling Yuan, Jason W Denbo, Eric H Jensen, Jane Y C Hui, Todd M Tuttle, Schelomo Marmor
BACKGROUND: The 21-gene recurrence score (RS) is a RT-PCR assay estimating risk of distant recurrence in estrogen receptor positive (ER+), human epidermal growth factor receptor 2 negative (HER2) breast cancer (BC). Studies validating RS are limited to women. Our objective was to assess RS distribution and factors associated with high-risk RS in male BC. METHODS: Using the Surveillance, Epidemiology, and End Results database, we identified men and women with ER+/HER2- BC from 2010 to 2013...
June 15, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29907935/circulating-mir-215-5p-and-mir-642a-5p-as-potential-biomarker-for-diagnosis-of-osteosarcoma-in-mexican-population
#10
Lucero Monterde-Cruz, Eric G Ramírez-Salazar, Genaro Rico-Martínez, Luis M Linares-González, Roberto Guzmán-González, Ernesto Delgado-Cedillo, Eréndira Estrada-Villaseñor, Margarita Valdés-Flores, Rafael Velázquez-Cruz, Alberto Hidalgo-Bravo
Osteosarcoma is the most common malignant bone neoplasia affecting individuals in the second decade of life. The survival rate has not been improved during the last 25 years, in part because of the lack of specific markers. The microRNAs have been identified as important regulators of gene expression, experimental evidence suggests these molecules as key players in cancer development and progression. To identify miRNAs differentially expressed in serum from patients with osteosarcoma compared to healthy donors in Mexican population...
June 15, 2018: Human Cell
https://www.readbyqxmd.com/read/29907893/semaglutide-s-c-once-weekly-in-type-2-diabetes-a-population-pharmacokinetic-analysis
#11
Kristin Cecilie Carlsson Petri, Steen Hvass Ingwersen, Anne Flint, Jeppe Zacho, Rune Viig Overgaard
INTRODUCTION: Semaglutide, a new treatment option approved for the treatment of patients with type 2 diabetes mellitus, is a glucagon-like peptide-1 receptor agonist to be injected subcutaneously once weekly. This analysis used a population pharmacokinetic model of semaglutide to identify clinically relevant covariates for exposure. METHODS: A total of 1612 patients with up to seven pharmacokinetic observations each were included in the analysis. All subjects had type 2 diabetes mellitus and were enrolled in one of five trials in the phase III development program for subcutaneous semaglutide once weekly (the SUSTAIN program)...
June 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29907885/recognition-and-control-of-hypertension-diabetes-and-dyslipidemia-in-patients-with-rheumatoid-arthritis
#12
Luísa Lima Castro, Cristina Costa Duarte Lanna, Mariana Pimenta Rocha, Antônio Luiz Pinho Ribeiro, Rosa Weiss Telles
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drugs used in its treatment, and a higher prevalence of traditional risk factors for CAD. Our aim is to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and diabetes mellitus (DM) in RA patients...
June 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#13
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907750/examining-the-associations-among-fibrocystic-breast-change-total-lean-mass-and-percent-body-fat
#14
Yuan-Yuei Chen, Wen-Hui Fang, Chung-Ching Wang, Tung-Wei Kao, Yaw-Wen Chang, Hui-Fang Yang, Chen-Jung Wu, Yu-Shan Sun, Wei-Liang Chen
Fibrocystic breast change (FBC) is extremely common and occurrs in 90% of women during their lives. The association between body composition and risk of breast cancer is well established. We hypothesized that the effect might exist during the development of FBC. Our aim was to examine the relationships of total lean mass (TLM) and percent body fat (PBF) with FBC in a general female population. In total, 8477 female subjects aged 20 years or older were enrolled in the study at the Tri-Service General Hospital in Taiwan from 2011 to 2016...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907699/decline-in-kidney-function-among-apparently-healthy-young-adults-at-risk-of-mesoamerican-nephropathy
#15
Marvin Gonzalez-Quiroz, Evangelia-Theano Smpokou, Richard J Silverwood, Armando Camacho, Dorien Faber, Brenda La Rosa Garcia, Amin Oomatia, Michael Hill, Jason Glaser, Jennifer Le Blond, Catharina Wesseling, Aurora Aragon, Liam Smeeth, Neil Pearce, Dorothea Nitsch, Ben Caplin
Background Epidemic levels of CKD of undetermined cause, termed Mesoamerican nephropathy in Central America, have been found in low- and middle-income countries. We investigated the natural history of, and factors associated with, loss of kidney function in a population at high risk for this disease. Methods We conducted a 2-year prospective, longitudinal study with follow-up every 6 months in nine rural communities in northwestern Nicaragua and included all men ( n =263) and a random sample of women ( n =87) ages 18-30 years old without self-reported CKD, diabetes, or hypertension...
June 15, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29907681/case-studies-of-gastric-lung-and-oral-cancer-connect-etiologic-agent-prevalence-to-cancer-incidence
#16
Andrew F Brouwer, Marisa C Eisenberg, Rafael Meza
Obtaining detailed individual-level data on both exposure and cancer outcomes is challenging, and it is difficult to understand and characterize how temporal aspects of exposures translate into cancer risk. We show that, in lieu of individual-level information, population-level data on cancer incidence and etiologic agent prevalence can be leveraged to investigate cancer mechanisms and to better characterize and predict cancer trends. We use mechanistic carcinogenesis models [multistage clonal expansion (MSCE) models] and data on smoking, Helicobacter pylori ( H...
June 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29907655/causes-and-predictors-of-readmission-in-patients-with-atrial-fibrillation-undergoing-catheter-ablation-a-national-population-based-cohort-study
#17
Shilpkumar Arora, Sopan Lahewala, Byomesh Tripathi, Varshil Mehta, Varun Kumar, Divya Chandramohan, Alejandro Lemor, Mihir Dave, Nileshkumar Patel, Nilay V Patel, Ghanshyam Palamaner Subash Shantha, Juan Viles-Gonzalez, Abhishek Deshmukh
BACKGROUND: Reducing readmission after catheter ablation (CA) in atrial fibrillation (AF) is important. METHODS AND RESULTS: We utilized National Readmission Data (NRD) 2010-2014. AF was identified by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic code 427.31 in the primary field, while first CA of AF was identified via ICD-9 -procedure code 37.34. Any admission within 30 or 90 days of index admission was considered a readmission...
June 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29907627/the-relationship-between-human-adenovirus-36-and-obesity-in-chinese-han-population
#18
Yan Zhou, Qi Pan, Xiaoxia Wang, Lina Zhang, Fei Xiao, Lixin Guo
The study aimed to explore the prevalence of human adenovirus-36 (HAdV-36) infection and the association of HAdV-36 with obesity in Chinese Han population. A qualitative determination using enzyme-linked immunosorbent assay was performed to determine by duplication the antibodies to HAdV-36 in the serum samples. Logistic regression analysis was used to analyze the association between HAdV-36 seropositivity and obesity. The overall HAdV-36 seroprevalence was 49.8% among 824 participants. The prevalence of HAdV-36 seropositive was 42...
June 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29907582/social-network-characteristics-are-associated-with-type-2-diabetes-complications-the-maastricht-study
#19
Stephanie Brinkhues, Nicole H T M Dukers-Muijrers, Christian J P A Hoebe, Carla J H van der Kallen, Annemarie Koster, Ronald M A Henry, Coen D A Stehouwer, Paul H M Savelkoul, Nicolaas C Schaper, Miranda T Schram
OBJECTIVE: The relation between clinical complications and social network characteristics in type 2 diabetes mellitus (T2DM) has hardly been studied. Therefore, we examined the associations of social network characteristics with macro- and microvascular complications in T2DM and investigated whether these associations were independent of glycemic control, quality of life, and well-known cardiovascular risk factors. RESEARCH DESIGN AND METHODS: Participants with T2DM originated from the Maastricht Study, a population-based cohort study ( n = 797, mean age 62...
June 15, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29907524/comparison-of-revision-risks-and-complication-rates-between-total-hip-replacement-and-hip-resurfacing-within-the-similar-age-group
#20
Veera Venkata Satyanarayana Eethakota, Vinod Vaishnav, Linda Johnston, Rami Abboud, Weijie Wang
BACKGROUND AND PURPOSE: Currently it is not clear whether age is a factor affecting revisions in total hip replacement (THR) and hip resurfacing (HR). This study aimed to investigate which of THR or HR has a higher risk in terms of revision and complication within similar age groups. METHODS: A systemic review was performed for published literature research databases and local data and compared the two procedures under the condition that both groups of patients were age matched...
June 12, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
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