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Cancer of the head and neck

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https://www.readbyqxmd.com/read/29054125/external-validation-of-a-cancer-risk-prediction-model-for-suspected-head-and-neck-cancer-referrals
#1
T Tikka, V Paleri, K MacKenzie
Head and neck cancer (HNC) affects more than 9000 new patients every year in England and Wales with an additional 1200 in Scotland. (1,2) Patients are urgently referred to head and neck clinics for further assessment when a suspicion of cancer is raised in the primary care setting. In England, the referral criteria are based on the NICE recommendations for symptoms associated with HNC. (2) A different combination of symptoms is described in the Scottish cancer referral guidelines. (3) There is currently no unified referral proforma across the different UK cancer networks...
October 20, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29053803/effect-of-radiation-on-sucrose-detection-thresholds-of-mice
#2
Benjamin C Jewkes, Linda A Barlow, Eugene R Delay
Radiotherapy is one of the most common treatments for head and neck cancers, with an almost obligate side effect of altered taste (Conger 1973). In mice, targeted irradiation of the head and neck causes transient repression of proliferation of basal epithelial cells responsible for taste cell replacement, leading to a temporary depletion of taste sensory cells within taste buds, including Type II taste cells involved in detection of sweet stimuli (Nguyen et al. 2012). These findings suggest that irradiation may elevate sucrose detection thresholds, peaking at 7 days post-irradiation when loss of Type II cells is greatest...
October 19, 2017: Chemical Senses
https://www.readbyqxmd.com/read/29053175/distinct-pattern-of-tp53-mutations-in-human-immunodeficiency-virus-related-head-and-neck-squamous-cell-carcinoma
#3
Frederico O Gleber-Netto, Mei Zhao, Sanchit Trivedi, Jiping Wang, Samar Jasser, Christina McDowell, Humam Kadara, Jiexin Zhang, Jing Wang, William N William, J Jack Lee, Minh Ly Nguyen, Sara I Pai, Heather M Walline, Dong M Shin, Robert L Ferris, Thomas E Carey, Jeffrey N Myers, Curtis R Pickering
BACKGROUND: Human immunodeficiency virus-infected individuals (HIVIIs) have a higher incidence of head and neck squamous cell carcinoma (HNSCC), and clinical and histopathological differences have been observed in their tumors in comparison with those of HNSCC patients without a human immunodeficiency virus (HIV) infection. The reasons for these differences are not clear, and molecular differences between HIV-related HNSCC and non-HIV-related HNSCC may exist. This study compared the mutational patterns of HIV-related HNSCC and non-HIV-related HNSCC...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053029/the-evidence-on-effectiveness-of-weekly-vs-triweekly-cisplatin-concurrent-with-radiotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-a-systematic-review-and-meta-analysis
#4
Jc Kennetth Jacinto, Jayson Co, Michael Benedict Mejia, Eugenio Emmanuel Regala
OBJECTIVE: This study aims to synthesize the current available evidences on the effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in the primary and adjuvant treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A systematic review and meta-analysis of literature were undertaken to assess the effectiveness of weekly vs triweekly schedule in primary and adjuvant treatment for HNSCC with adverse risk features...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29051792/papillary-thyroid-cancer-recurrence-43%C3%A2-years-following-total-thyroidectomy-and-radioactive-iodine-ablation-a-case-report
#5
Yaw Amoako-Tuffour, M Elise Graham, Martin Bullock, Matthew H Rigby, Jonathan Trites, S Mark Taylor, Robert D Hart
BACKGROUND: Recurrent papillary thyroid carcinoma (PTC) beyond the first two decades of definitive treatment (i.e. total thyroidectomy and radioactive iodine ablation) is a rare occurrence. CASE PRESENTATION: We present a case of a 71-year old Caucasian female with a distant history of PTC treated with total thyroidectomy and radioactive iodine ablation who experienced recurrence of her disease 43 years following initial diagnosis and definitive treatment. She presented with palpable left-sided neck mass and subsequently underwent a level II, III, neck dissection and adjuvant iodine ablation...
2017: Thyroid Research
https://www.readbyqxmd.com/read/29051281/cancer-in-the-national-cancer-institute-inherited-bone-marrow-failure-syndrome-cohort-after-15-years-of-follow-up
#6
Blanche P Alter, Neelam Giri, Sharon A Savage, Philip S Rosenberg
The National Cancer Institute Inherited Bone Marrow Failure Syndromes Cohort enrolls patients with the four major syndromes: Fanconi anemia, dyskeratosis congenita, Diamond Blackfan anemia, and Shwachman Diamond syndrome, and follows them with a common comprehensive protocol. The current analysis includes more than double the numbers of patients and person-years since our first report in 2010. Patients with Fanconi anemia and dyskeratosis congenita developed head and neck and anogenital squamous cell carcinomas at rates that are hundreds-fold greater than the general population...
October 19, 2017: Haematologica
https://www.readbyqxmd.com/read/29051113/body-composition-early-identifies-cancer-patients-with-radiotherapy-at-risk-for-malnutrition
#7
Pei-Ling Tang, Hsiu-Hung Wang, Huey-Shyan Lin, Wen-Shan Liu, Lih-Mih Chen, Fan-Hao Chou
BACKGROUND: The side effects of radiotherapy (RT) and the occurrence of comorbidity often result in appetite loss in patients, which leads to serious nutritional problems, significantly affecting the patients' treatment results and disease prognosis. OBJECTIVES: We aimed to investigate changes in the body composition of patients with cancer from the time they received RT to 3 months after completion of RT. DESIGN: A total of 101 cancer patients who received RT, which included head or neck cancer, chest or breast cancer, and abdominal or pelvic cancer patients...
October 16, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29050538/evaluation-of-the-head-and-neck-cancer-patient-population-and-the-incidence-of-hospitalization-at-an-academic-medical-center
#8
Lindsay A Hazelden, Matthew J Newman, Stephanie Shuey, Julie M Waldfogel, Victoria T Brown
Purpose Patients with head and neck cancer are at risk for disease- and treatment-related toxicities that may be severe enough to require hospitalization. The risk factors associated with hospitalization in these patients are not well defined. Methods We conducted a single-center, retrospective observational study of patients with head and neck cancer receiving chemotherapy at an academic medical center infusion clinic in a one-year period. The primary objective was to characterize the head and neck cancer population at an academic medical center...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29049841/predictive-value-of-the-8th-edition-american-joint-commission-cancer-ajcc-nodal-staging-system-for-patients-with-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#9
Jessica Liu, Ardalan Ebrahimi, Tsu-Hui Hubert Low, Kan Gao, Carsten E Palme, Ch'ng Sydney, Bruce G Ashford, N Gopalakrishna Iyer, Jonathan R Clark, Ruta Gupta
BACKGROUND: The 8th edition American Joint Committee on Cancer (AJCC8) provides the same nodal staging system for mucosal and cutaneous squamous cell carcinoma of the head and neck (HNcSCC) and includes extranodal extension (ENE) as an adverse prognostic criterion. This study evaluates the prognostic efficacy of the AJCC8 pathologic nodal staging system (pN) for HNcSCC. METHODS: Univariate analysis of 382 patients with metastatic HNcSCC staged according to both the 7th (AJCC7) and the 8th edition staging systems...
October 19, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29049429/correlation-of-handheld-reflectance-confocal-microscopy-with-radial-video-mosaicing-for-margin-mapping-of-lentigo-maligna-and-lentigo-maligna-melanoma
#10
Oriol Yélamos, Miguel Cordova, Nina Blank, Kivanc Kose, Stephen W Dusza, Erica Lee, Milind Rajadhyaksha, Kishwer S Nehal, Anthony M Rossi
Importance: The management of lentigo maligna (LM) and LM melanoma (LMM) is challenging because of extensive subclinical spread and its occurrence on cosmetically sensitive areas. Reflectance confocal microscopy (RCM) improves diagnostic accuracy for LM and LMM and can be used to delineate their margins. Objectives: To evaluate whether handheld RCM with radial video mosaicing (HRCM-RV) offers accurate presurgical assessment of LM and LMM margins. Design, Setting, and Participants: This prospective study included consecutive patients with biopsy-proven LM and LMM located on the head and neck area who sought consultation for surgical management from March 1, 2016, through March 31, 2017, at the Dermatology Service of the Memorial Sloan Kettering Cancer Center...
October 11, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049342/association-between-a-mirna-146a-polymorphism-and-susceptibility-to-head-and-neck-squamous-cell-carcinoma-in-chinese-patients-a-meta-analysis-of-8-case-control-studies
#11
Silin Zhang, Fangling Hu, Hongxing Liang, Yuanzhou Liu, Jianqiang Yang, Wensheng Zhou
A closer association has been found between the microRNA-146a rs2910164 polymorphism and the risk of head and neck carcinoma in some molecular epidemiological studies. Recently two meta-analyses were performed to explore the relationship between miRNA-146a polymorphisms and the susceptibility of squamous cell carcinoma of the head and neck (SCCHN); however, they yielded conflicting results in susceptibility regarding ethnic variations. Hence, the present study was performed to explain the relationship between the miRNA-146a rs2910164 polymorphism and the risk of SCCHN development of Chinese patients...
2017: PloS One
https://www.readbyqxmd.com/read/29049027/atlas-ranking-and-selection-for-automatic-segmentation-of-the-esophagus-from-ct-scans
#12
Jinzhong Yang, Benjamin Haas, Raymond Fang, Beth B Beadle, Adam S Garden, Zhongxing Liao, Lifei Zhang, Peter A Balter, Laurence E Court
In radiation treatment planning, the esophagus is an important organ-at-risk that should be spared in patients with head and neck cancer or thoracic cancer who undergo intensity-modulated radiation therapy. However, automatic segmentation of the esophagus from CT scans is extremely challenging because of the structure's inconsistent intensity, low contrast against the surrounding tissues, complex and variable shape and location, and random air bubbles. The goal of this study is to develop an online atlas selection approach to choose a subset of optimal atlases for multi-atlas segmentation to delineate esophagus automatically...
October 19, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29048671/adoptive-immunotherapy-combined-with-fp-treatment-for-head-and-neck-cancer-an-in%C3%A2-vitro-study
#13
Mayako Nishio-Nagai, Susumu Suzuki, Kazuhiro Yoshikawa, Ryuzo Ueda, Yoshiaki Kazaoka
FP treatment, which combines 5-fluorouracil (5-FU) and cisplatin (CDDP) chemotherapy, is widely used for treatment of advanced head and neck cancer (HNC). It has been suggested that these drugs cause immunomodulation in the cancer microenvironment, for example, downregulation of immunosuppressive cells such as regulatory T-cells (Tregs) and myeloid-derived suppressive cells (MDSCs), activating dendritic cells (DCs), and upregulation of tumor antigens and major histocompatibility complex (MHC) molecules in cancer cells leads to enhancement of cancer immunity, which is important in cancer treatment, as well as providing a direct killing effect...
October 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29047105/%C3%AE-secretase-inhibitor-reduces-immunosuppressive-cells-and-enhances-tumour-immunity-in-head-and-neck-squamous-cell-carcinoma
#14
Liang Mao, Zhi-Li Zhao, Guang-Tao Yu, Lei Wu, Wei-Wei Deng, Yi-Cun Li, Jian-Feng Liu, Lin-Lin Bu, Bing Liu, Ashok B Kulkarni, Wen-Feng Zhang, Lu Zhang, Zhi-Jun Sun
Immune evasion is a hallmark feature of cancer, and it plays an important role in tumour initiation and progression. In addition, tumour immune evasion severely hampers the desired antitumour effect in multiple cancers. In this study, we aimed to investigate the role of the Notch pathway in immune evasion in the head and neck squamous cell carcinoma (HNSCC) microenvironment. We first demonstrated that Notch1 signalling was activated in a Tgfbr1/Pten-knockout HNSCC mouse model. Notch signalling inhibition using a γ-secretase inhibitor (GSI-IX, DAPT) decreased tumour burden in the mouse model after prophylactic treatment...
October 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29045700/prediction-model-of-critical-weight-loss-in-cancer-patients-during-particle-therapy
#15
Zhihong Zhang, Y Zhu, Lijuan Zhang, Ziying Wang, Hongwei Wan
Background and purpose: The objective of this study is to investigate the predictors of critical weight loss in cancer patients receiving particle therapy, and build a prediction model based on its predictive factors. Materials and methods: Patients receiving particle therapy were enroled between June 2015 and June 2016. Body weight was measured at the start and end of particle therapy. Association between critical weight loss (defined as >5%) during particle therapy and patients' demographic, clinical characteristic, pre-therapeutic nutrition risk screening (NRS 2002) and BMI were evaluated by logistic regression and decision tree analysis...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045516/navigating-the-highlights-of-phase-iii-trials-a-watchful-eye-on-evidence-based-radiotherapy
#16
J C Trone, S Espenel, A Rehailia-Blanchard, E Guillaume, N Vial, C Rancoule, C Rodriguez-Lafrasse, M Ben Mrad, A El Meddeb Hamrouni, E Ollier, C Chargari, E Deutsch, A Vallard, N Magné
Background: Phase III randomized controlled trials (RCTs) are the cornerstone of evidence-based oncology. However, there is no exhaustive review describing the radiotherapy RTCs characteristics. The objective of the present study was to describe features of all phase III RCTs including at least a radiation therapy. Methods and materials: Requests were performed in the Medline database (via PubMed). The latest update was performed in April 2016, using the following MESH terms: 'clinical trials: phase III as topic', 'radiotherapy', 'brachytherapy', as keywords...
July 12, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045513/dpyd-genotype-guided-dose-individualization-to-improve-patient-safety-of-fluoropyrimidine-therapy-call-for-a-drug-label-update
#17
L M Henricks, F L Opdam, J H Beijnen, A Cats, J H M Schellens
The fluoropyrimidine anticancer drugs, especially 5-fluorouracil (5-FU) and capecitabine, are frequently prescribed for several types of cancer, including breast, colorectal, head and neck and gastric cancer. In the current drug labels of 5-FU and capecitabine in the European Union and the United States of America no adaptive dosing strategies are incorporated for polymorphic metabolism of 5-FU.Although treatment with fluoropyrimidines is generally well tolerated, a major clinical limitation is that a proportion of the treated population experiences severe, sometimes life-threatening, fluoropyrimidine-related toxicity...
August 2, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044881/local-control-in-sinonasal-malignant-melanoma-comparing-conventional-to-hypofractionated-radiotherapy
#18
Jules Lansu, Willem Martin Klop, Wilma Heemsbergen, Arash Navran, Abrahim Al-Mamgani, Johannes A Langendijk, Johannes H Kaanders, Chris Terhaard, Baris Karakullukcu, Olga Hamming-Vrieze
BACKGROUND: The purpose of this study was to analyze the effect of fractionation schedule on local control in postoperative radiotherapy (RT) for sinonasal malignant melanoma. METHODS: Sixty-three patients who were treated with surgery and postoperative RT in 4 accredited head and neck cancer centers in the Netherlands between 1998 and 2013 were retrospectively studied. Outcomes with conventional fractionation (2-2.4 Gy per fraction; n = 27) were compared to hypofractionation (4-6 Gy per fraction; n = 36)...
October 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29044879/exercise-therapy-for-trismus-secondary-to-head-and-neck-cancer-a-systematic-review
#19
Jolanda I Kamstra, Marianne van Leeuwen, Jan L N Roodenburg, Pieter U Dijkstra
BACKGROUND: Effects of exercise therapy for trismus secondary to head and neck cancer have not been reviewed systematically since 2004. METHODS: Four databases were searched. The quality of observational studies and randomized controlled trials was assessed. RESULTS: Two hundred eleven articles were found, 20 studies were included. A large variation in research methodology, stretching techniques, duration of stretch, and repetition of exercises was found...
November 2017: Head & Neck
https://www.readbyqxmd.com/read/29044862/efficacy-and-safety-of-vinorelbine-plus-cisplatin-chemotherapy-for-patients-with-recurrent-and-or-metastatic-salivary-gland-cancer-of-the-head-and-neck
#20
Min Hee Hong, Chang Gon Kim, Yoon Woo Koh, Eun Chang Choi, Jinna Kim, Sun Och Yoon, Hye Ryun Kim, Byoung Chul Cho
BACKGROUND: The purpose of this study was to investigate the efficacy and safety of vinorelbine plus cisplatin chemotherapy in patients with recurrent and/or metastatic salivary gland cancer of the head and neck. METHODS: In this single-arm phase II study, patients with recurrent and/or metastatic salivary gland cancer were treated with i.v. vinorelbine (25 mg/m(2) ) on days 1 and 8 plus cisplatin (80 mg/m(2) ) on day 1 every 3 weeks for 4 or 6 cycles. The primary endpoint was the objective response rate...
October 16, 2017: Head & Neck
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