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Biomarkers endothelial damage

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https://www.readbyqxmd.com/read/29320534/the-endothelial-specific-isoform-of-type-xviii-collagen-correlates-to-annual-bleeding-rate-in-haemophilia-patients
#1
Nadja Gad Kjeld, Baolai Hua, Morten Asser Karsdal, Shu Sun, Tina Manon-Jensen
INTRODUCTION: The medical need in the haemophilic (HF) field to reduce bleeding incidents requires measurement of the annual bleeding rate (ABR) in haemophiliacs. Vascular rupture is associated with damage to the vascular endothelium causing exposure of the basement membrane. Endothelial cells and matrix impairment may be associated with joint bleeds and later development of HF arthropathy. Imbalanced extracellular matrix turnover is a central pathological feature in many diseases consequent to epithelial or endothelial cell damage...
2018: PloS One
https://www.readbyqxmd.com/read/29316855/the-role-of-noninvasive-cardiovascular-testing-applied-clinical-nutrition-and-nutritional-supplements-in-the-prevention-and-treatment-of-coronary-heart-disease
#2
Mark Houston
Numerous clinical trials suggest that we have reached a limit in our ability to decrease the incidence of coronary heart disease (CHD) and cardiovascular disease (CVD) utilizing the traditional diagnostic evaluation, prevention and treatment strategies for the top five cardiovascular risk factors of hypertension, diabetes mellitus, dyslipidemia, obesity and smoking. About 80% of heart disease (heart attacks, angina, coronary heart disease and congestive heart failure) can be prevented by optimal nutrition, optimal exercise, optimal weight and body composition, mild alcohol intake and avoiding smoking...
January 1, 2018: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/29306249/biomarker-and-shear-stress-in-secondary-pediatric-pulmonary-hypertension
#3
Ayhan Pektaş, Rana Olguntürk, Serdar Kula, Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu
Background/aim: Endothelial dysfunction, tissue damage, inflammation, and microthrombosis are involved in the pathogenesis of pulmonary hypertension (PH), which may be present as a complication of congenital heart diseases. This study aims to identify how indicators of endothelial dysfunction (shear stress), tissue damage (brain natriuretic peptide and troponin T), inflammation (C-reactive protein (CRP)), and microthrombosis (D-dimer and von Willebrand factor) are altered in children with congenital left-to-right shunting...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29287004/non-invasive-markers-of-portal-hypertension-appraisal-of-adult-experience-and-potential-utilisation-in-children
#4
Harry Sutton, Anil Dhawan, Tassos Grammatikopoulos
Portal Hypertension (PHT) is a significant cause of morbidity and mortality in children with chronic liver disease (CLD) and portal vein obstruction. Increased portal pressure results in variceal formation along the gastrointestinal (GI) tract resulting in major bleeding. Identifying children with significant PHT who are more likely to suffer GI bleeding has been challenging and the role of surveillance upper GI endoscopy has been debated. This review analyses research done on serum biomarkers and imaging techniques as possible predictors of significant PHT...
December 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29278852/adipokines-in-neurovascular-diseases
#5
REVIEW
Radka Opatrilova, Martin Caprnda, Peter Kubatka, Vanda Valentova, Sona Uramova, Vladimir Nosal, Ludovit Gaspar, Lukas Zachar, Ioana Mozos, Daniel Petrovic, Jozef Dragasek, Slavomira Filipova, Dietrich Büsselberg, Anthony Zulli, Luis Rodrigo, Peter Kruzliak, Vladimir Krasnik
Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke...
December 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29245956/combination-therapy-of-exendin-4-and-allogenic-adipose-derived-mesenchymal-stem-cell-preserved-renal-function-in-a-chronic-kidney-disease-and-sepsis-syndrome-setting-in-rats
#6
Chih-Hung Chen, Ben-Chung Cheng, Kuan-Hung Chen, Pei-Lin Shao, Pei-Hsun Sung, Hsin-Ju Chiang, Chih-Chao Yang, Kun-Chen Lin, Cheuk-Kwan Sun, Jiunn-Jye Sheu, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
Combined therapy with exendin-4 (Ex4) and allogenic adipose-derived mesenchymal stem cells (ADMSC) was tested against either therapy alone for protecting kidney function against chronic kidney disease (CKD) complicated by sepsis syndrome (SS) [i.e., by intraperitoneal injection of cecal-derived bacteria (1.0 × 104) cells/milliliter/total 5.0 cc].Adult-male-Sprague Dawley rats (n=36) were equally divided into group 1 (sham-control), group 2 (CKD), group 3 (CKD-SS), group 4 (CKD-SS-Ex4), group 5 (CKD-SS-ADMSC) and group 6 (CKD-SS-Ex4-ADMSC)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226690/low-levels-of-endothelial-progenitor-cells-and-their-association-with-systemic-inflammation-and-monocyte-activation-in-older-hiv-infected-men
#7
Sophie Seang, Theodoros Kelesidis, Diana Huynh, Sangeun Park, Ardis Moe, Judith Currier, Jordan E Lake
BACKGROUND: Endothelial progenitor cells (EPCs) repair damaged vascular endothelium and low circulating EPC levels have been associated with cardiovascular disease (CVD). CD34+/KDR+ EPCs are commonly reported in literature and CD34+/CD133+/KDR+ EPCs are rare in circulation but highly specific for endothelial lineage. HIV-infected (HIV+) adults have chronic inflammation and increased CVD risk, but the relationship between CVD, vascular inflammation and EPCs in HIV remains unclear. METHODS: In a pilot study, EPCs were measured in 57 HIV+ men (≧50 years old, HIV-1 RNA <50 copies/mL on ART) by real-time flow cytometry using cellular immaturity (CD34 and/or CD133) and endothelial commitment (KDR) markers...
December 10, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29218106/extracorporeal-shock-wave-therapy-effectively-protects-brain-against-chronic-cerebral-hypo-perfusion-induced-neuropathological-changes
#8
Han-Tan Chai, Kuan-Hung Chen, Christopher Glenn Wallace, Chih-Hung Chen, Pei-Hsun Sung, Yung-Lung Chen, Chun-Man Yuen, Pei-Lin Shao, Cheuk-Kwan Sun, Hsueh-Wen Chang, Ching-Jen Wang, Mel S Lee, Hon-Kan Yip, Sheung-Fat Ko
This study tested the hypothesis that extracorporeal shock wave (ECSW) therapy could protect mouse brain from chronic cerebral hypoperfusion (CHP)-induced neuropathological changes in a bilateral carotid arterial stenosis (CAS) model. Adult-male C57BL/6 (B6) mice (n=36) were randomized into group 1 (sham-control), group 2 (CHP) and group 3 [CHP+ECSW (100 impulses at 0.15 mJ/mm2) on day 5, 10 and 15 after CHP induction]. By day 60 after CHP induction, the white matter lesion, protein expressions of inflammatory (TNF-α/NF-κB/iNOS), oxidative-stress (NOX-1/NOX-2/NOX-4/nitrotyrosine), angiogenesis (eNOS/CD31), apoptotic (Bax/caspase-3/PARP), fibrotic (Smad3/TGF-ß) and mitochondrial-damaged (cytosolic cytochrome-C) biomarkers were significantly higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1, whereas the protein expressions of anti-apoptotic (Bcl-2), anti-fibrotic (BMP-2/Smad1/5), and mitochondrial-integrity (mitochondrial cytochrome-C) biomarkers showed an opposite pattern to inflammation among the three groups (all P<0...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29198509/testosterone-deficiency-causes-endothelial-dysfunction-via-elevation-of-asymmetric-dimethylarginine-and-oxidative-stress-in-castrated-rats
#9
Tomoya Kataoka, Yuji Hotta, Yasuhiro Maeda, Kazunori Kimura
BACKGROUND: Testosterone is believed to mediate the penile erectile response by producing adequate nitric oxide; therefore, testosterone deficiency results in erectile dysfunction through decreased nitric oxide bioavailability. However, the mechanisms underlying endothelial dysfunction in testosterone deficiency remain unclear. AIM: To investigate the mechanism of endothelial dysfunction in a rat model of testosterone deficiency. METHODS: Rats were distributed into 3 groups: castrated (Cast), castrated and supplemented with testosterone (Cast + T), and sham (Sham)...
December 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29195999/the-effect-of-raisins-on-biomarkers-of-endothelial-function-and-oxidant-damage-an-open-label-and-randomized-controlled-intervention
#10
Panagiotis T Kanellos, Andriana C Kaliora, Athanasios D Protogerou, Nikolaos Tentolouris, Despina N Perrea, Vaios T Karathanos
Based on the existing data in grapes and wine, the aim of the present study was to investigate the probability that raisins improve clinical features and markers of oxidative stress, inflammation and arterial function in healthy smokers. Thirty-six apparently healthy smokers were recruited to an open-label and randomized, controlled, 4-week prospective intervention. All participants were reported to consume less than the recommended amount of five servings fruits and vegetables daily. Participants in the intervention were instructed to consume raisins equal to five fruit servings (90g/d)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29182425/endothelial-alterations-in-a-canine-model-of-immune-thrombocytopenia
#11
Dana N LeVine, Rachel E Cianciolo, Keith E Linder, Petra Bizikova, Adam J Birkenheuer, Marjory B Brooks, Abdelghaffar K Salous, Shila K Nordone, Dwight A Bellinger, Henry Marr, Sam L Jones, Thomas H Fischer, Yu Deng, Marshall Mazepa, Nigel S Key
Bleeding heterogeneity amongst patients with immune thrombocytopenia (ITP) is poorly understood. Platelets play a role in maintaining endothelial integrity, and variable thrombocytopenia-induced endothelial changes may influence bleeding severity. Platelet-derived endothelial stabilizers and markers of endothelial integrity in ITP are largely underexplored. We hypothesized that, in a canine ITP model, thrombocytopenia would lead to alterations in the endothelial ultrastructure and that the Von Willebrand factor (vWF) would serve as a marker of endothelial injury associated with thrombocytopenia...
November 28, 2017: Platelets
https://www.readbyqxmd.com/read/29164711/vitamin-e-improves-testicular-damage-in-streptozocin-induced-diabetic-rats-via-increasing-vascular-endothelial-growth-factor-and-poly-adp-ribose-polymerase-1
#12
S S Omar, R G Aly, N M Badae
The precise mechanism by which diabetes impairs spermatogenesis and testicular function is not exactly known. Vascular endothelial growth factor (VEGF) and poly(ADP-ribose) polymerase-1 (PARP-1) are important for germ cell homeostasis and repair of DNA respectively. The aim of this study was to investigate the correlation between diabetes-induced testicular damage and testicular VEGF and PARP-1 expression and the possible protective role of vitamin E supplementation. A total of 45 male Wistar albino rats were randomly divided into three groups: Group I (nondiabetic rats), Group II (streptozocin-induced diabetic rats) and Group III (streptozocin-induced diabetic rats treated orally with 0...
November 21, 2017: Andrologia
https://www.readbyqxmd.com/read/29162432/renal-damage-in-the-metabolic-syndrome-metsx-disorders-implicated
#13
REVIEW
Trujillo Joyce, Chirino Yolanda Irasema, Martínez-Tagüeña Natalia, Pedraza-Chaverri Jose
The prevalence of metabolic syndrome is increasing worldwide and has become a risk factor for the development of chronic kidney disease. The complex linkage between metabolic syndrome and chronic kidney disease is under research and the factors involved beyond the biological pathogenesis include demographic, sociological and psychological factors that are related to the metabolic syndrome prevalence. The social context of disease causation is as relevant to today's clinical scientist and practitioner as biomarker-directed risk stratification and therapy...
November 18, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29152859/deletion-of-the-egf-receptor-in-vascular-smooth-muscle-cells-prevents-chronic-angiotensin-ii-induced-arterial-wall-stiffening-and-media-thickening
#14
Barbara Schreier, Mirja Hünerberg, Sigrid Mildenberger, Sindy Rabe, Daniel Bethmann, Claudia Wickenhauser, Michael Gekle
AIM: In vivo vascular smooth muscle cell (VSMC) EGF receptor (EGFR) contributes to acute angiotensin II (AII) effects on vascular tone and blood pressure. The ubiquitously expressed EGFR has been implicated in vascular remodeling preceding end-organ damage by pharmacological inhibition, and AII signaling in cultured vascular cells is partly EGFR dependent. However the role of VSMC-EGFR in vivo during AII-induced pathophysiological processes is not known. METHODS: The present study assesses the in vivo relevance of VSMC-EGFR during chronic AII challenge without further stressors, using a mouse model with inducible, VSMC-specific EGFR knock out (VSMC-EGFR-KO)...
November 20, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29150149/pregnancy-and-heart-disease-pregnancy-associated-hypertension-and-peripartum-cardiomyopathy
#15
Tobias Jonathan Pfeffer, Denise Hilfiker-Kleiner
Cardiovascular diseases are major complications in pregnancy worldwide and the number of patients who develop cardiac problems during pregnancy is increasing. Pregnancy-associated hypertensive complications such as pre-eclampsia (PE) or peripartum cardiomyopathy (PPCM) are potentially life-threatening heart diseases emerging during pregnancy, under delivery or in the first postpartal months in previously healthy women. Both disease entities display substantial morbidity and mortality in the acute phase. Long-term effects are just beginning to be evaluated...
October 31, 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/29148423/non-invasive-vascular-biomarkers-in-patients-with-beh%C3%A3-et-s-disease-review-of-the-data-and-future-perspectives
#16
REVIEW
Athanase D Protogerou, Efthimia G Nasothimiou, Petros P Sfikakis, Athanasios G Tzioufas
Vascular inflammation in small to large veins and arteries contributes substantially to mortality above that of the general population in Behçet's disease. Recent data verified also the presence of accelerated classical subclinical arterial damage (atheromatosis, arteriosclerosis, arterial hypertrophy) even in patients free of overt vascular complications, and may be complementary to that of vasculitis. Early detection of such vascular damage might provide helpful pathophysiological insight and potentially even guide treatment management...
November 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29131327/cgrp-and-ptx3-as-predictors-of-efficacy-of-onabotulinumtoxin-type-a-in-chronic-migraine-an-observational-study
#17
Clara Domínguez, Alba Vieites-Prado, María Pérez-Mato, Tomás Sobrino, Xiana Rodríguez-Osorio, Ana López, Francisco Campos, Francisco Martínez, José Castillo, Rogelio Leira
OBJECTIVE: The aim of this study is to find a relation between several biomarkers in peripheral blood and outcome after treatment with onabotulinumtoxin A (OnabotA). BACKGROUND: OnabotA is an effective treatment in chronic migraine (CM). Different studies have tried to find predictors of response to treatment, either with clinical characteristics, neuroimaging features, or molecular biomarkers; however, it is still not possible to predict the individual outcome...
November 13, 2017: Headache
https://www.readbyqxmd.com/read/29116998/mesenchymal-stem-cells-from-bone-marrow-adipose-tissue-and-lung-tissue-differentially-mitigate-lung-and-distal-organ-damage-in-experimental-acute-respiratory-distress-syndrome
#18
Johnatas D Silva, Miquéias Lopes-Pacheco, Ana H R Paz, Fernanda F Cruz, Elga B Melo, Milena V de Oliveira, Débora G Xisto, Vera L Capelozzi, Marcelo M Morales, Paolo Pelosi, Elizabeth Cirne-Lima, Patricia R M Rocco
OBJECTIVES: Mesenchymal stem cells-based therapies have shown promising effects in experimental acute respiratory distress syndrome. Different mesenchymal stem cells sources may result in diverse effects in respiratory diseases; however, there is no information regarding the best source of mesenchymal stem cells to treat pulmonary acute respiratory distress syndrome. We tested the hypothesis that mesenchymal stem cells derived from bone marrow, adipose tissue, and lung tissue would lead to different beneficial effects on lung and distal organ damage in experimental pulmonary acute respiratory distress syndrome...
November 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29112510/prediction-of-postpercutaneous-coronary-intervention-myocardial-infarction-insights-from-intravascular-imaging-coronary-flow-and-biomarker-evaluation
#19
Stephen P Hoole, Jules Hernández-Sánchez, Adam J Brown, Joel P Giblett, Martin R Bennett, Nick E J West
BACKGROUND: Percutaneous coronary intervention-induced myocardial infarction (PMI) has prognostic significance. Identifying patients at high risk for PMI is desirable as it may alter strategy and facilitate early preventative therapy. We therefore sought to establish whether preprocedural demographic, interventional (plaque characteristics and coronary microcirculatory function), and inflammatory, endothelial damage, and platelet-derived biomarker data could predict the risk of PMI. PATIENTS AND METHODS: We performed target vessel pressure wire to assess fractional flow reserve, index of microcirculatory resistance (IMR) and coronary flow reserve, plaque characterization by virtual histology intravascular ultrasound, and assayed peripheral biomarkers before uncomplicated PCI in 88 patients...
November 6, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29056520/characterization-of-immune-cell-endothelial-and-renal-responses-upon-experimental-human-endotoxemia
#20
Eveline P van Poelgeest, Marlous R Dillingh, Marieke de Kam, Karen E Malone, Marleen Kemper, Erik S G Stroes, Jacobus Burggraaf, Matthijs Moerland
INTRODUCTION: Although the effects of relatively high concentrations of endotoxin on endothelial activation/dysfunction and kidney markers has been described in literature, detailed insight in the LPS concentration-effect relationship, the magnitude, variability and timing of the response, and potential effects of endotoxemia on the kidneys is lacking. A study was performed to assess the effects of low- to moderate dose (0.5, 1 or 2ng/kg) endotoxemia on the endothelium and kidneys as measured by a panel of novel highly sensitive kidney injury markers...
October 19, 2017: Journal of Pharmacological and Toxicological Methods
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