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Biomarkers endothelial damage

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https://www.readbyqxmd.com/read/27908668/associations-between-urinary-biomarkers-of-oxidative-stress-and-air-pollutants-observed-in-a-randomized-crossover-exposure-to-steel-mill-emissions
#1
Guillaume Pelletier, Marc Rigden, Lisa Marie Kauri, Robin Shutt, Mamun Mahmud, Sabit Cakmak, Premkumari Kumarathasan, Errol M Thomson, Renaud Vincent, Gayle Broad, Ling Liu, Robert Dales
The effects of industrial air pollution on human health have not been as thoroughly investigated as those of urban air pollution which originates mostly from automotive transport. To better assess the health impacts of point sources of industrial air pollution, a randomized crossover exposure study was conducted. Sixty one young and healthy volunteers were randomly assigned to spend five consecutive eight-hour days near a steel mill or at a location five kilometres away. After a nine or sixteen-day washout period, volunteers spent another five consecutive days at the second site...
November 25, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/27904658/circulating-microparticles-enhanced-rat-vascular-wall-remodeling-following-endothelial-denudation
#2
Fan-Yen Lee, Hung-I Lu, Han-Tan Chai, Jiunn-Jye Sheu, Yi-Ling Chen, Tein-Hung Huang, Gour-Shenq Kao, Sheng-Yi Chen, Sheng-Ying Chung, Pei-Hsun Sung, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
This study tested the hypothesis that circulating microparticles (MPs) exacerbated vascular wall (VW) remodeling after endothelial denudation by 0.014 wire in a rat model. Adult male Sprague Dawley rats (n = 40) were equally categorized into group 1 [sham-control (SC); 3.0 mL saline intravenous injection], group 2 [SC + intravenous MPs (1.0 × 10(7)) derived from patients with carotid artery stenosis (CAS)], group 3 [femoral arterial endothelial denudation (FAED)], group 4 (FAED + MPs derived from healthy subjects), and group 5 (FAED + CAS-derived MPs)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27901469/obestatin-improves-hepatic-injury-induced-by-ischemia-reperfusion-in-rats-role-of-nitric-oxide
#3
Ola A El-Gohary
Hepatic ischemia/reperfusion (I/R) injury is a common clinical problem. The present study was conducted to evaluate the protective effect of obestatin against I/R-induced liver injury. Rats were divided into three groups (n = 10): control sham-operated group, I/R group and obestatin treatment group. Rats of I/R group and obestatin treatment group underwent partial hepatic ischemia for 60 min followed by 90 min reperfusion. At the beginning of the 90-min reperfusion period, rats of obestatin treatment group were injected with obestatin (100 μg/kg) intravenously...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27843374/potential-serum-and-urine-biomarkers-in-patients-with-lupus-nephritis-and-the-unsolved-problems
#4
REVIEW
Song-Chou Hsieh, Chang-Youh Tsai, Chia-Li Yu
Lupus nephritis (LN) is one of the most frequent and serious complications in the patients with systemic lupus erythematosus. Autoimmune-mediated inflammation in both renal glomerular and tubulointerstitial tissues is the major pathological finding of LN. In clinical practice, the elevated anti-dsDNA antibody titer concomitant with reduced complement C3 and C4 levels has become the predictive and disease-activity surrogate biomarkers in LN. However, more and more evidences suggest that autoantibodies other than anti-dsDNA antibodies, such as anti-nucleosome, anti-C1q, anti-C3b, anti-cardiolipin, anti-endothelial cell, anti-ribonuclear proteins, and anti-glomerular matrix (anti-actinin) antibodies, may also involve in LN...
2016: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/27814594/cardiac-allograft-vasculopathy-microvascular-arteriolar-capillaries-capioles-and-survival
#5
Carlos A Labarrere, Beate R Jaeger, Ghassan S Kassab
Cardiac allograft vasculopathy (CAV) is a serious complication of heart transplantation in adults and children. Risk factors include human leukocyte antigen mismatches, number and duration of rejection episodes, type of immunosuppression, antibody-mediated rejection, hypertension, hyperlipidemia, obesity, smoking, diabetes, cytomegalovirus infection, mode of donor brain death, donor age and ischemia/reperfusion injury. Endothelial injury and dysfunction in CAV are characterized by changes in adhesion molecules and up-regulation of major histocompatibility class II antigens followed by endothelial activation of complement C4d...
January 1, 2017: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/27809797/the-usefulness-of-cyfra-21-1-to-diagnose-and-predict-preeclampsia-a-nested-case-control-study
#6
Lorenz Kuessel, Harald Zeisler, Robin Ristl, Julia Binder, Petra Pateisky, Maximilian Schmid, Julian Marschalek, Thomas Perkmann, Helmuth Haslacher, Heinrich Husslein
BACKGROUND: The ability to identify patients at risk for developing preeclampsia is important for preventing morbidity and mortality in both the mother and child. Although CYFRA 21-1 (a fragment of Cytokeratin 19) is considered a promising biomarker for diagnosing preeclampsia, little is known regarding the levels of CYFRA 21-1 during pregnancy. Here, we measured serum CYFRA 21-1 levels in women with an uneventful pregnancy and in women whose pregnancy was complicated by preeclampsia...
November 3, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27806914/micrornas-in-the-pathophysiology-of-ckd-mbd-biomarkers-and-innovative-drugs
#7
REVIEW
Valérie Metzinger-Le Meuth, Stéphane Burtey, Pierre Maitrias, Ziad A Massy, Laurent Metzinger
microRNAs comprise a novel class of endogenous small non-coding RNAs that have been shown to be implicated in both vascular damage and bone pathophysiology. Chronic kidney disease-mineral bone disorder (CKD-MBD) is characterized by vessel and bone damage secondary to progressive loss of kidney function. In this review, we will describe how several microRNAs have been implicated, in recent years, in cellular and animal models of CKD-MBD, and have been very recently shown to be deregulated in patients with CKD...
October 30, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27794222/neovasculature-and-circulating-tumor-cells-dual-targeting-nanoparticles-for-the-treatment-of-the-highly-invasive-breast-cancer
#8
Jianhui Yao, Jingxian Feng, Xiaoling Gao, Dan Wei, Ting Kang, Qianqian Zhu, Tianze Jiang, Xunbin Wei, Jun Chen
Antiangiogenesis therapy has been served as a potent cancer treatment strategy for decades, yet disrupting neovasculature would provoke tumor cells into invasive growth and result in distal metastasis. The basic cause of cancer metastasis can be traced down to the presence of circulating tumor cells (CTCs) which detach from primary tumor site and act as 'seeds'. Epithelial cell adhesion molecule (EpCAM) is a potential biomarker for selective capture of epithelium-derived CTCs. Here, we integrated tumor neovessles-targetable ligands K237 peptide with Ep23 aptamer against EpCAM into a single drug-loaded nanoplatform using paclitaxel (PTX) as the model drug, aiming at damaging the primary tumor and neutralizing CTCs simultaneously to achieve a synergistic anti-tumor therapeutic effect...
October 22, 2016: Biomaterials
https://www.readbyqxmd.com/read/27779595/sympathoadrenal-activation-and-endotheliopathy-are-drivers-of-hypocoagulability-and-hyperfibrinolysis-in-trauma-a-prospective-observational-study-of-404-severely-injured-patients
#9
Sisse R Ostrowski, Hanne H Henriksen, Jakob Stensballe, Mikkel Gybel-Brask, Jessica C Cardenas, Lisa A Baer, Bryan A Cotton, John B Holcomb, Charles E Wade, Pär I Johansson
BACKGROUND: One third of severely injured patients present with a laboratory based diagnosis of coagulopathy. This study investigated clinical and biomarker profile of patients with rapid TEG (rTEG) coagulopathy hypothesizing that sympathoadrenal activation and endothelial damage were drivers of this condition. METHODS: Prospective observational study of 404 trauma patients admitted to a Level 1 US Trauma Center. Patients with admission rTEG and plasma measurements of catecholamines (adrenaline, noradrenaline) and biomarkers reflecting endothelial activation/damage (syndecan-1, thrombomodulin, sE-selectin, sVE-cadherin, nucleosomes) were included...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27774366/differential-response-of-human-embryonic-stem-and-somatic-cells-to-non-cytotoxic-hydrogen-peroxide-exposure-an-attempt-to-model-in-vitro-the-effects-of-oxidative-stress-on-the-early-embryo
#10
M Barandalla, S Colleoni, G Lazzari
Human Embryonic Stem Cells (hESCs) potentially offer a unique in vitro model to study how an adverse environment during the early developmental stages post-fertilization can affect the physiology of the undifferentiated embryonic stem cells existing in the early embryo and predispose to long term effects on the offspring, according to the Developmental Origins of Health and Disease (DOHaD) concept. A number of unfavourable conditions can affect the development of the early embryo inducing oxidative stress both in vivo, for instance in gestational diabetes and in vitro, when embryos are derived from Assisted Reproductive Technologies (ART)...
August 2016: Cell & Developmental Biology
https://www.readbyqxmd.com/read/27766047/microrna-in-atherothromobosis-is-it-useful-as-a-disease-marker
#11
Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27753900/os-01-09-markers-of-early-renal-impairment-in-prehypertension
#12
Ana Vrdoljak, Vanja Ivković, Sandra Karanović, Živka Dika, Ivana Vuković, Jelena Kos, Mario Laganović, Tajana Željković Vrkić, Margareta Fištrek Prlić, Ivan Pećin, Bojan Jelaković
OBJECTIVE: It was observed that glomerular hyperfiltration (GHF) is associated with progression of kidney disease in diabetics, patients in stage 1 hypertension (HT), and we found previously that eGFR decreased faster also in prehypertensives (PHT) with GHF. Here we analyzed whether GHF in PHT is associated with other biomarkers of early renal impairment. DESIGN AND METHOD: From 954 subjects enrolled in ENAH follow-up study, 371(137 m;mean age = 46years) were eligible for further analysis:100 with optimal,72 with normal BP,70 with PHT(high normal BP),and 129 with newly diagnosed untreated HT...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27722638/attenuation-of-oxidative-stress-in-type-1-diabetic-rats-supplemented-with-a-seasoning-obtained-from-winemaking-by-products-and-its-effect-on-endothelial-function
#13
Raquel Del Pino-García, María D Rivero-Pérez, María L González-SanJosé, Pablo Castilla-Camina, Kevin D Croft, Pilar Muñiz
Type 1 diabetes mellitus (DM) is characterized by hyperglycemia resulting from insulin deficiency. This is usually accompanied by a pro-oxidative environment, dyslipidemia and endothelial dysfunction, thus leading to several micro- and macro-vascular complications. This study investigated the potential benefits of a seasoning obtained from seedless red wine pomace (RWPS) in protecting against oxidative damage and preserving endothelial function in Type 1 DM, and the underlying mechanisms involved at the level of gene expression...
October 12, 2016: Food & Function
https://www.readbyqxmd.com/read/27708207/role-of-oncogene-24p3-neutrophil-gelatinase-associated-lipocalin-ngal-in-digestive-system-cancers
#14
Łukasz Michalak, Magdalena Bulska, Katarzyna Kudłacz, Piotr Szcześniak
Neutrophil gelatinase-associated lipocalin, known also as 24p3 lipocalin, lipocalin-2 or uterocalin (in mouse), is a small secretory protein binding small molecular weight ligands which takes part in numerous processes including apoptosis induction in leukocytes, iron transport, smell, and prostaglandins and retinol transport [19]. It was discovered in activated neutrophils as a covalent peptide associated with human gelatinase neutrophils [7]. Neutrophil lipocalin is secreted physiologically in the digestive system, respiratory tract, renal tubular cells, liver or immunity system...
January 4, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27687026/fatigue-and-cognitive-function-in-systemic-lupus-erythematosus-associations-with-white-matter-microstructural-damage-a-diffusion-tensor-mri-study-and-meta-analysis
#15
S J Wiseman, M E Bastin, I F Hamilton, D Hunt, S J Ritchie, E N Amft, S Thomson, J F F Belch, S H Ralston, J M Wardlaw
OBJECTIVE: The objective of this study was to investigate fatigue and cognitive impairments in systemic lupus erythematous (SLE) in relation to diffuse white matter microstructural brain damage. METHODS: Diffusion tensor MRI, used to generate biomarkers of brain white matter microstructural integrity, was obtained in patients with SLE and age-matched controls. Fatigue and cognitive function were assessed and related to SLE activity, clinical data and plasma biomarkers of inflammation and endothelial dysfunction...
September 29, 2016: Lupus
https://www.readbyqxmd.com/read/27683177/liver-microvascular-injury-and-thrombocytopenia-of-antibody-calicheamicin-conjugates-in-cynomolgus-monkeys-mechanism-and-monitoring
#16
Magali Guffroy, Hadi Falahatpisheh, Kathleen Biddle, John Kreeger, Leslie Obert, Karen Walters, Richard Goldstein, Germaine Boucher, Tim Coskran, William Reagan, Danielle Sullivan, Chunli Huang, Sharon A Sokolowski, Richard Giovanelli, Hans-Peter Gerber, Martin B Finkelstein, Nasir K Khan
PURPOSE: Adverse reactions reported in patients treated with antibody-calicheamicin conjugates such as gemtuzumab ozogamicin (GO, Mylotarg®) and inotuzumab ozogamicin (IO) include thrombocytopenia and sinusoidal obstruction syndrome (SOS). The objective of this experimental work was to investigate the mechanism for thrombocytopenia, characterize the liver injury and identify potential safety biomarkers. EXPERIMENTAL DESIGN: Cynomolgus monkeys were dosed intravenously at 6 mg/m2/dose once every 3 weeks with a non-binding antibody-calicheamicin conjugate (PF-0259) containing the same linker-payload as GO and IO...
September 28, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27682003/ctni-exacerbates-myocardial-ischemia-reperfusion%C3%A2-injury%C3%A2-by-inducing-adhesion-of-monocytes-to%C3%A2-vecs-via-%C3%A2-tlr4-nf-%C3%AE%C2%BAb-dependent-pathway
#17
Yu Han, Xiang Liao, Zhao Gao, Sufei Yang, Caiyu Chen, Yukai Liu, Wei Eric Wang, Gengze Wu, Xiongwen Chen, Pedro A Jose, Ye Zhang, Chunyu Zeng
Cardiac troponin I (cTnI), a biomarker for myocardial damage and risk stratification, may be involved in the pathogenesis of cardiovascular diseases, which was ascribed to the effect of cTnI auto-antibodies. Whether or not cTnI itself has a direct impact on acute myocardial injury is unknown. To exclude the influence of cTnI antibody on the cardiac infarct size, we studied the effect of cTnI shortly after myocardial ischemia-reperfusion (I/R) injury when cTnI antibodies were not elevated. Pretreatment with cTnI augmented the myocardial infarct size caused by I/R, accompanied by an increase in inflammatory markers in the blood and myocardium...
September 28, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27643246/os-01-09-markers-of-early-renal-impairment-in-prehypertension
#18
Ana Vrdoljak, Vanja Ivković, Sandra Karanović, Živka Dika, Ivana Vuković, Jelena Kos, Mario Laganović, Tajana Željković Vrkić, Margareta Fištrek Prlić, Ivan Pećin, Bojan Jelaković
OBJECTIVE: It was observed that glomerular hyperfiltration (GHF) is associated with progression of kidney disease in diabetics, patients in stage 1 hypertension (HT), and we found previously that eGFR decreased faster also in prehypertensives (PHT) with GHF. Here we analyzed whether GHF in PHT is associated with other biomarkers of early renal impairment. DESIGN AND METHOD: From 954 subjects enrolled in ENAH follow-up study, 371(137 m;mean age = 46years) were eligible for further analysis:100 with optimal,72 with normal BP,70 with PHT(high normal BP),and 129 with newly diagnosed untreated HT...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27633456/the-mir-221-222-cluster-is-a-key-player-in-vascular-biology-via-the-fine-tuning-of-endothelial-cell-physiology
#19
Tanja Celic, Valérie Metzinger-Le Meuth, Isabelle Six Ziad A Massy, Laurent Metzinger
The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by endothelial cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases...
September 14, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27631127/heat-shock-protein-90%C3%AE-is-a-potential-serological-biomarker-of-acute-rejection-after-renal-transplantation
#20
Takeshi Maehana, Toshiaki Tanaka, Hiroshi Kitamura, Nobuyuki Fukuzawa, Hideki Ishida, Hiroshi Harada, Kazunari Tanabe, Naoya Masumori
BACKGROUND: Heat shock protein 90 (HSP90), a molecular chaperone associated with the activation of client proteins, was recently reported to play an important role in immunologic reactions. To date, the role of HSP90 in solid organ transplantations has remained unknown. The aim of this study was to evaluate the relationship between serum HSP90α levels and acute allograft rejection after organ and tissue transplantation using serum samples from kidney allograft recipients, an in vitro antibody-mediated rejection model, and a murine skin transplantation...
2016: PloS One
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