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Cancer of oropharynx

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https://www.readbyqxmd.com/read/29451617/trends-in-social-security-benefits-for-oral-and-oropharyngeal-cancer-from-2006-to-2013-in-brazil
#1
Rafael Aiello Bomfim, Andreia Morales Cascaes
OBJECTIVE: to analyze the trends in the concession of social security sick pay for oral and oropharyngeal cancer, from 2006 to 2013, in Brazil. METHODS: time series study using data of workers insured by the Brazilian National Institute of Social Security (INSS); Prais-Winsten generalized linear regressions were used to calculate the annual percentage change (APC). RESULTS: social security benefits for oral and oropharyngeal cancer presented significant increase (APC=9...
2018: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/29447885/pediatric-head-and-neck-squamous-cell-carcinoma-patient-demographics-treatment-trends-and-outcomes
#2
Ankit Modh, Omar H Gayar, Mohamed A Elshaikh, Arnold C Paulino, Farzan Siddiqui
OBJECTIVES: To examine patient demographics, temporal and treatment trends, and survival outcomes of pediatric non-nasopharyngeal head and neck squamous cell carcinomas using the National Cancer Database. METHODS: The National Cancer Database was queried for pediatric patients (age 0-19 years) diagnosed with squamous cell carcinoma of the head and neck (including oral cavity, oropharynx, nasal cavity, larynx, hypopharynx, and salivary glands) from 2004 to 2013. RESULTS: Of 159 patients identified, the majority had oral cavity SCC (55%)...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29440171/crosstalk-signaling-between-her3-and-hpv16-e6-and-e7-mediates-resistance-to-pi3k-inhibitors-in-head-and-neck-cancer
#3
Toni M Brand, Stefan Hartmann, Neil E Bhola, Hua Li, Yan Zang, Rachel A O'Keefe, Max V Ranall, Sourav Bandyopadhyay, Margaret Soucheray, Nevan J Krogan, Carolyn Kemp, Umamaheswar Duvvuri, Theresa LaVallee, Daniel E Johnson, Michelle A Ozbun, Julie E Bauman, Jennifer R Grandis
Human papillomavirus (HPV) type 16 is implicated in approximately 75% of head and neck squamous cell carcinomas (HNSCC) that arise in the oropharynx, where viral expression of the E6 and E7 oncoproteins promote cellular transformation, tumor growth, and maintenance. An important oncogenic signaling pathway activated by E6 and E7 is the phosphatidylinositol 3-kinase (PI3K) pathway, a key driver of carcinogenesis. The PI3K pathway is also activated by mutation or amplification of PIK3CA in over half of HPV(+) HNSCC...
February 12, 2018: Cancer Research
https://www.readbyqxmd.com/read/29435836/oral-and-dental-health-in-head-and-neck-cancer-patients
#4
Joel B Epstein, Andrei Barasch
A diagnosis of head and neck cancer (HNC) is typically followed by therapy that is associated with immediate and long-lasting toxic consequences. HNC patients' oral health needs may be complex and are best addressed in multidisciplinary collaborative teams including surgical, medical, and radiation oncologists, dental providers, nutrition, speech/swallow specialists, and physical therapists. Oral health maintenance also requires patient compliance and caregiver support. The role of dental providers begins prior to cancer diagnosis and continues through survivorship...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29425228/kshv-oral-shedding-and-plasma-viremia-result-in-significant-changes-in-the-extracellular-tumorigenic-mirna-expression-profile-in-individuals-infected-with-the-malaria-parasite
#5
Minako Ikoma, Soren Gantt, Corey Casper, Yuko Ogata, Qing Zhang, Ryan Basom, Michael R Dyen, Timothy M Rose, Serge Barcy
Kaposi's sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). Both KSHV and HIV infections are endemic in Uganda, where KS is among the most common cancers in HIV-infected individuals. Recent studies examined the use of small RNAs as biomarkers of disease, including microRNAs (miRNAs), with viral and tumor-derived miRNAs being detected in exosomes from individuals with KSHV-associated malignancies. In the current study, the host and viral extracellular mature miRNA expression profiles were analyzed in blood of KS-negative individuals in Uganda, comparing those with or without KSHV detectable from the oropharynx...
2018: PloS One
https://www.readbyqxmd.com/read/29417586/office-based-esophageal-dilation-in-head-and-neck-cancer-safety-feasibility-and-cost-analysis
#6
Rebecca J Howell, Melissa A Schopper, John Paul Giliberto, Ryan M Collar, Sid M Khosla
OBJECTIVE: To review experience, safety, and cost of office-based esophageal dilation in patients with history of head and neck cancer (HNCA). METHODS: The medical records of patients undergoing esophageal dilation in the office were retrospectively reviewed between August 2015 and May 2017. Patients were given nasal topical anesthesia. Next, a transnasal esophagoscopy (TNE) was performed. If the patient tolerated TNE, we proceeded with esophageal dilation using Seldinger technique with the CRE™ Boston Scientific (Boston Scientific Corp...
February 8, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29415020/the-evolution-of-the-epidemiological-landscape-of-head-and-neck-cancer-in-italy-is-there-evidence-for-an-increase-in-the-incidence-of-potentially-hpv-related-carcinomas
#7
Paolo Boscolo-Rizzo, Manuel Zorzi, Annarosa Del Mistro, Maria Cristina Da Mosto, Giancarlo Tirelli, Carlotta Buzzoni, Massimo Rugge, Jerry Polesel, Stefano Guzzinati
The current study aimed to investigate the incidence and survival patterns of HNSCCs arising from different anatomic sites, potentially related (the oropharynx) or unrelated (the oral cavity, the larynx/hypopharynx) to HPV, to provide clues on possible growing impact of HPV in the epidemiology of HNSCC in Italy. Epidemiological data were retrieved from ten long-term Cancer Registries covering a population of 7.8 million inhabitants. Trends were described by means of the estimated annual percent change (APC) stratified by age and gender, and compared between HPV-related and HPV-unrelated anatomical sites...
2018: PloS One
https://www.readbyqxmd.com/read/29408738/prevalence-and-genotypes-of-human-papillomavirus-in-saliva-and-tumor-samples-of-head-and-neck-cancer-patients-in-hungary
#8
Andrea Hettmann, Anett Demcsák, Ádám Bach, Gábor Decsi, Ágnes Dencs, Dóra Pálinkó, László Rovó, Gabriella Terhes, Edit Urbán, Krisztina Buzás, Katalin Nagy, Mária Takács, Janos Minarovits
In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hungary, data regarding HPV prevalence in HNSCCs is scarce. We collected biopsy and saliva samples from patients diagnosed with HNSCC or oral potentially malignant disorders (OPMDs) and tested them for the presence of HPV using the PCR consensus primer set MY09/11 and the GP5+/6+ primer pair...
January 31, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29402786/rigid-triple-endoscopy-improves-clinical-staging-of-primary-head-and-neck-cancer
#9
Shachi J Sharma, Jens J Linke, Tobias Kroll, Nora Wuerdemann, Jens P Klussmann, Orlando Guntinas-Lichius, Claus Wittekindt
BACKGROUND: Correct pre-therapeutic staging of the first primary carcinoma (FPC) and detection of simultaneous second primary carcinomas (SSPCs) decisively influence therapy and prognosis of head and neck squamous cell carcinomas (HNSCC). The aim of this study was to determine the benefit of pre-therapeutic triple endoscopy for detection of SSPC and pre-therapeutic T category. METHODS: A cohort of 234 HNSCC patients with completed triple endoscopy was reviewed, focusing on pre-therapeutic T category and SSPC...
2018: Oncology Research and Treatment
https://www.readbyqxmd.com/read/29385294/outcomes-utilizing-intensity-modulated-radiotherapy-in-oropharyngeal-cancers-tonsils-versus-base-of-tongue
#10
Madhava R Kanakamedala, Shankar P G Giri, Robert D Hamilton, Eldrin Bhanat, Srinivasan Vijayakumar
BACKGROUND: The purpose of this study was to present the outcomes of oropharyngeal cancers treated with intensity-modulated radiotherapy (IMRT) especially the differences between tonsillar and base of tongue (BOT) primaries. METHODS: Retrospective analysis of 124 patients with biopsy proven squamous cell carcinomas of the oropharynx, treated with IMRT. RESULTS: Human papillomavirus (HPV) association correlated with improvement in survivals in both tonsillar and BOT primaries...
January 31, 2018: Head & Neck
https://www.readbyqxmd.com/read/29383312/pattern-of-gustatory-impairment-and-its-recovery-after-head-and-neck-irradiation
#11
Preety Negi, Pamela-Alice Kingsley, Maria Thomas, Jaineet Sachdeva, Himanshu Srivastava, Babusha Kalra
Introduction: The majority of patients receiving concurrent chemoradiotherapy frequently complain of changes in their taste perception, and other distressing symptoms affecting their quality of life. This study was undertaken to determine the pattern of gustatory impairment and its recovery in irradiated head and neck cancer patients in India. Materials and Methods: Thirty patients undergoing radical head and neck irradiation were enrolled and assessed for the four basic taste quality (sweet, salt, sour and bitter) by a forced three-choice stimulus drop technique measuring their taste recognition thresholds at baseline, weekly during radiation therapy (RT) and every month for 6 months following completion of RT...
November 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29371888/identification-of-genomic-copy-number-variations-associated-with-specific-clinical-features-of-head-and-neck-cancer
#12
Boris Zagradišnik, Danijela Krgović, Špela Stangler Herodež, Andreja Zagorac, Bogdan Ćižmarević, Nadja Kokalj Vokač
Background: Copy number variations (CNSs) of large genomic regions are an important mechanism implicated in the development of head and neck cancer, however, for most changes their exact role is not well understood. The aim of this study was to find possible associations between gains/losses of genomic regions and clinically distinct subgroups of head and neck cancer patients. Results: Array comparative genomic hybridization (aCGH) analysis was performed on DNA samples in 64 patients with cancer in oral cavity, oropharynx or hypopharynx...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29371473/single-arm-phase-ii-study-of-cisplatin-docetaxel-and-erlotinib-in-patients-with-recurrent-and-or-metastatic-head-and-neck-squamous-cell-carcinomas
#13
William N William, Anne S Tsao, Lei Feng, Lawrence E Ginsberg, J Jack Lee, Merrill S Kies, Bonnie S Glisson, Edward S Kim
LESSONS LEARNED: The combination of cisplatin, docetaxel, and erlotinib as frontline treatment for recurrent and/or metastatic head and neck squamous cell carcinomas led to a response rate of 62%.This result exceeded the prespecified target response rate of 50% and represented an improvement compared with historical controls.This regimen warrants further investigation. BACKGROUND: The epidermal growth factor receptor (EGFR) plays a key role in the carcinogenesis of head and neck squamous cell carcinomas (HNSCC)...
January 25, 2018: Oncologist
https://www.readbyqxmd.com/read/29361647/-hpv-and-oropharyngeal-squamous-cell-cancer-in-the-8th-edition-of-the-tnm-classification
#14
Markus Hoffmann, Silke Tribius
The 8th edition of the TNM classification, available since January 1st, 2017, has changed the classification of variou s tumors. For head and neck squamous cell cancer (HNSCC) of the oropharynx (OPC) the new edition distinguishes between HPV-positive and HPV-negative disease to better reflect the prognostic implication of HPV associated disease. In many cases applying the new TNM-classification in HPV-positive OPC results in downstaging of formerly locally advanced disease, i. e. UICC III/ IV, into localized disease UICC stage I/II...
January 23, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29355614/head-and-neck-squamous-cell-carcinoma-genomics-and-emerging-biomarkers-for-immunomodulatory-cancer-treatments
#15
REVIEW
Benjamin Solomon, Richard J Young, Danny Rischin
Head and neck squamous cell carcinoma (HNSCC) comprises a heterogeneous group of tumors that arise from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. While many HNSCCs are related to classical etiologic factors of smoking and alcohol, a clinically, genomically, and immunologically distinct subgroup of tumors arise from the epithelium of the tonsil and the base of tongue as a result of infection with Human Papilloma Virus (HPV). In this review we describe the genomic and immunologic landscape of HNSCC, highlighting differences between HPV-positive and HPV-negative HNSCC...
January 17, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29338089/outcomes-of-patients-diagnosed-with-carcinoma-metastatic-to-the-neck-from-an-unknown-primary-source-and-treated-with-intensity-modulated-radiation-therapy
#16
Mona Kamal, Abdallah S R Mohamed, Clifton David Fuller, Erich M Sturgis, Faye M Johnson, William H Morrison, G Brandon Gunn, Katherine A Hutcheson, Jack Phan, Stefania Volpe, Sweet Ping Ng, Renata Ferrarotto, Steven J Frank, Heath D Skinner, David I Rosenthal, Adam S Garden
BACKGROUND: There are few published studies to guide the treatment of carcinoma metastatic to the neck from an unknown primary (CUP). In this regard, the objective of the current study was to share the authors' current experience treating patients with CUP using intensity-modulated radiation therapy (IMRT), which principally targeted both sides of the neck, the nasopharynx, and the oropharynx. METHODS: This was a retrospective study in which an institutional database search was conducted to identify patients with CUP who received IMRT...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29323421/head-and-neck-cancer-tumor-seeding-at-the-percutaneous-endoscopic-gastrostomy-site
#17
REVIEW
June R Greaves
The National Institutes of Health National Cancer Institute estimates that over 13,000 new cases of head and neck cancer (HNC) will be diagnosed in 2017. Patients with HNC often require enteral nutrition (EN) via gastrostomy tube to provide nutrition support and hydration because of tumor obstruction of the oropharynx and/or cumulative effects of chemoradiation therapy. The percutaneous endoscopic gastrostomy (PEG) tube has become the preferred technique for EN access because placement is considered a minimally invasive procedure...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29315499/increased-pathologic-upstaging-with-rising-time-to-treatment-initiation-for-head-and-neck-cancer-a-mechanism-for-increased-mortality
#18
Roy Xiao, Matthew C Ward, Kailin Yang, David J Adelstein, Shlomo A Koyfman, Brandon L Prendes, Brian B Burkey
BACKGROUND: Time to treatment initiation (TTI) is increasing and is associated with worsening survival. In the current study, the authors sought to identify a mechanism for this relationship by assessing the effect of TTI on clinical-to-pathologic upstaging in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: Using the National Cancer Data Base, the authors analyzed patients receiving definitive surgery for SCC of the oral cavity, oropharynx, larynx, and hypopharynx from 2005 through 2014...
January 9, 2018: Cancer
https://www.readbyqxmd.com/read/29312616/detection-of-hpv-related-oropharyngeal-cancer-in-oral-rinse-specimens
#19
Matthew Rosenthal, Bin Huang, Nora Katabi, Jocelyn Migliacci, Robert Bryant, Samuel Kaplan, Timothy Blackwell, Snehal Patel, Liying Yang, Zhiheng Pei, Yi-Wei Tang, Ian Ganly
Background: The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Methods: Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29303995/local-acetaldehyde-an-essential-role-in-alcohol-related-upper-gastrointestinal-tract-carcinogenesis
#20
REVIEW
Mikko T Nieminen, Mikko Salaspuro
The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a significant risk factor for oral and esophageal carcinogenesis and is characterized by a dysbiotic microbiome. Dysbiosis leads to increased growth of opportunistic pathogens (such as Candida yeasts) and may cause an up to 100% increase in the local ACH production, which is further modified by organ-specific expression and gene polymorphisms of ethanol-metabolizing and ACH-metabolizing enzymes...
January 5, 2018: Cancers
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