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Biomarkers oxidative stress

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https://www.readbyqxmd.com/read/29775960/strategies-to-decrease-oxidative-stress-biomarker-levels-in-human-medical-conditions-a-meta-analysis-on-8-iso-prostaglandin-f-2%C3%AE
#1
Thomas J van 't Erve
The widespread detection of elevated oxidative stress levels in many medical conditions has led to numerous efforts to design interventions to reduce its effects. Efforts have been wide-ranging, from dietary changes to administration of antioxidants, supplements, e.g., omega-3-fatty acids, and many medications. However, there is still no systemic assessment of the efficacy of treatments for oxidative stress reduction across a variety of medical conditions. The goal of this meta-analysis is, by combining multiple studies, to quantitate the change in the levels of the popular oxidative stress biomarker 8-iso-prostaglandin F2α (8-iso-PGF2α ) after a variety of treatment strategies in human populations...
May 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29774032/protein-o-glcnac-modification-increases-in-white-blood-cells-after-a-single-bout-of-physical-exercise
#2
Tamás Nagy, Emese Kátai, Viktória Fisi, Tamás Tibor Takács, Antal Stréda, István Wittmann, Attila Miseta
Background: Protein O-linked N -acetylglucosamine (O-GlcNAc) is a dynamic posttranslational modification influencing the function of many intracellular proteins. Recently it was revealed that O-GlcNAc regulation is modified under various stress states, including ischemia and oxidative stress. Aside from a few contradictory studies based on animal models, the effect of exercise on O-GlcNAc is unexplored. Purpose: To evaluate O-GlcNAc levels in white blood cells (WBC) of human volunteers following physical exercise...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29768055/age-related-effect-of-aerobic-exercise-training-on-antioxidant-and-oxidative-markers-in-the-liver-challenged-by-doxorubicin-in-rats
#3
Mehdi Ahmadian, Valiollah Dabidi Roshan, Anthony S Leicht
The aims of the current study were to investigate the oxidant and antioxidant status of liver tissue challenged by doxorubicin and to examine the possible protective effects of aerobic exercise on doxorubicin-induced oxidative stress. Seventy-two rats were divided into three age groups (Young, Adult, and Elderly) with three treatment subgroups consisting of eight rats per age group: doxorubicin, aerobic exercise + doxorubicin, and aerobic exercise + saline. The experimental groups performed regular treadmill running for 3 weeks...
May 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29764335/comparative-bioaccumulation-and-effects-of-purified-and-cellular-extract-of-cylindrospermopsin-to-freshwater-fish-hoplias-malabaricus
#4
Rodrigo de Cássio da Silva, Sonia Regina Grötzner, Daniele Dietrich Moura Costa, Juan Ramón Esquivel Garcia, Juan Muelbert, Valéria Freitas de Magalhães, Francisco Filipak Neto, Ciro Alberto de Oliveira Ribeiro
Many tropical freshwater ecosystems are impacted by cyanobacteria blooms increasing the risk of cyanotoxins exposure to aquatic organisms while human populations may be exposed by eating fish, drinking water, or dermal swimming. However, few toxicological data are available on the influence of cyanobacteria blooms in particular, cylindrospermopsin (CYN) on Brazilian neotropical fish. A number of studies demonstrated the ability of CYN to bioaccumulate in freshwater organisms and consequently enter the human food chain...
May 15, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29763839/salivary-fingerprint-of-simple-obesity
#5
Anna Lehmann-Kalata, Izabela Miechowicz, Katarzyna Korybalska, Ewelina Swora-Cwynar, Natasza Czepulis, Joanna Łuczak, Zofia Orzechowska, Marian Grzymisławski, Anna Surdacka, Janusz Witowski
BACKGROUND: The nature of a link between poor oral health and obesity is not fully understood. It is also unclear if saliva contributes to it and whether the properties of saliva change as a result of an increase in body mass or rather as a consequence of obesity-associated comorbidities. This pilot study was undertaken in an attempt to determine if salivary biomarkers can identify obesity per se. METHODS: Whole mixed saliva was analysed for 16 soluble parameters covering 4 categories (inflammation, oxidative stress, endothelial dysfunction, adipokines)...
May 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29763686/mice-deficient-in-aldo-keto-reductase-1a-akr1a-are-resistant-to-thioacetamide-induced-liver-injury
#6
Takujiro Homma, Takaya Shirato, Ryusuke Akihara, Sho Kobayashi, Jaeyong Lee, Ken-Ichi Yamada, Satoshi Miyata, Motoko Takahashi, Junichi Fujii
Aldehyde reductase (Akr1a) has been reported to be involved in detoxification of reactive aldehydes as well as in the synthesis of bioactive compounds such as ascorbic acid (AsA). Because Akr1a is expressed at high levels in the liver and is involved in xenobiotic metabolism, our objective was to investigate the hepato-protective role of Akr1a in a thioacetamide (TAA)-induced hepatotoxicity model using Akr1a-deficient (Akr1a-/- ) mice. Wild-type (WT) and Akr1a-/- mice were injected intraperitoneally with TAA and the extent of liver injury in the acute phase was assessed...
May 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29762849/effects-of-smoking-on-thiol-disulfide-homeostasis
#7
I Solak, C D Cetinkaya, Y T Gederet, B Kozanhan, O Erel, M A Eryilmaz
OBJECTIVE: Cigarette smoking is an important risk factor for many diseases. This study aimed to evaluate whether cigarette smoking is associated with changes in the thiol/disulfide homeostasis (TDH), a novel biomarker of systemic oxidative stress. PATIENTS AND METHODS: Eighty-four smokers and 86 non-smoking healthy volunteers were enrolled. Serum native thiol, disulfide and total thiol levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were analyzed using a new colorimetric method...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29761206/imaging-of-oxygen-and-hypoxia-in-cell-and-tissue-samples
#8
REVIEW
Dmitri B Papkovsky, Ruslan I Dmitriev
Molecular oxygen (O2 ) is a key player in cell mitochondrial function, redox balance and oxidative stress, normal tissue function and many common disease states. Various chemical, physical and biological methods have been proposed for measurement, real-time monitoring and imaging of O2 concentration, state of decreased O2 (hypoxia) and related parameters in cells and tissue. Here, we review the established and emerging optical microscopy techniques allowing to visualize O2 levels in cells and tissue samples, mostly under in vitro and ex vivo, but also under in vivo settings...
May 14, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29760603/relationship-between-aerobic-capacity-with-oxidative-stress-and-inflammation-biomarkers-in-the-blood-of-older-mexican-urban-dwelling-population
#9
Juana Rosado-Pérez, Víctor Manuel Mendoza-Núñez
The maximal oxygen uptake (VO2max) constitutes an indicator of an organism's capacity to integrate oxygen into the metabolism to obtaining energy. The aim of this study was to determine the relationship between VO2max and oxidative stress (OxS) and chronic inflammation in the elderly individuals. A cross-sectional and exploratory study was conducted in a sample of 52 older persons. We measured plasma lipid peroxides (LPO), red blood cell glutathione peroxidase, red blood cell superoxide dismutase, and total antioxidant status...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29758497/growth-and-recovery-of-zebrafish-embryos-after-developmental-exposure-to-raw-and-ozonated-oil-sands-process-affected-water
#10
Danielle D Lyons, Christie Morrison, Danielle A Philibert, Mohamed Gamal El-Din, Keith B Tierney
Due to the increasing volume of oil sands process-affect water (OSPW) and its toxicity to aquatic organisms, it is important to fully understand its effects and study remediation processes that will enable its release to the environment. Ozone treatment is currently being considered as a tool to expedite remediation, as it is known to degrade toxic organic compounds present in OSPW. In this study, we aimed to measure the effects of OSPW exposure on the growth, development and recovery of zebrafish (Danio rerio) embryos...
May 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29758248/beneficial-effect-of-etazolate-on-depression-like-behavior-and-learning-and-memory-impairment-in-a-model-of-parkinson-s-disease
#11
Karem H Alzoubi, Enas Mokhemer, Amjad N Abuirmeileh
The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD). This aim was achieved through comparing 6-OHDA lesioned rats in the presence and absence of etazolate. The 6-OHDA was used to induce lesion as a model of PD. Etazolate was administered at a dose of 1 mg/kg/day for 14 days, starting 7 days after lesion induction. Apomorphine-induced rotation test was used to evaluate 6-OHDA-induced motor deficits, tail suspension test was used to assess depression-like symptoms, and the radial arms water maze (RAWM) was used to evaluate special learning and memory functions...
May 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29757418/associations-of-arsenic-exposure-with-telomere-length-and-na%C3%A3-ve-t-cells-in-childhood-a-birth-cohort-study
#12
Tania Mannan, Sultan Ahmed, Evana Akhtar, Khalid Bin Ahsan, Ahsanul Haq, Maria Kippler, Marie Vahter, Rubhana Raqib
There is limited knowledge of association between arsenic exposure and telomere length (TL) and signal joint T-cell receptor excision circle (sjTREC) that are potential biomarkers of immune senescence and disease susceptibility. We aimed to clarify whether long-term inorganic arsenic exposure influences TL and sjTRECs in childhood. Children born in a longitudinal mother-child cohort were followed-up at 4.5 (n=275) and 9 years (n=351) of age. Arsenic exposure was assessed by metabolite concentrations in urine (U-As) from mothers at gestational week 8 (prenatal) and their children at 4...
May 10, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29756347/pre-diagnostic-urinary-15-f-2t-isoprostane-level-and-liver-cancer-risk-results-from-the-shanghai-women-s-and-men-s-health-studies
#13
Xiao Ma, Yu-Ting Tan, Yang Yang, Jing Gao, Hong-Lan Li, Wei Zheng, Qing Lan, Nathaniel Rothman, Xiao-Ou Shu, Yong-Bing Xiang
Oxidative stress has been hypothesized to affect cancer development via various mechanisms, but the evidence from human is limited and inconclusive. 15-F2t -isoprostane (15-F2t -IsoP) is an accurate marker of oxidative stress in humans. Recent studies showed that the evidence of urinary 15-F2t -IsoP level correlating cancer risk is conflicting. We conducted a case-control study nested within two population-based cohort studies. Pre-diagnosis urine samples, collected at cohort enrollment, from 363 incident liver cancer cases and 725 individually matched controls, were used to determine the level of 15-F2t -IsoP by enzyme-linked immunosorbent assay...
May 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29754283/association-between-selenium-and-malondialdehyde-as-an-efficient-biomarker-of-oxidative-stress-in-infantile-cardiac-surgery
#14
Marlice Oliveira de Oliveira Ulbrecht, Daniel Araujo Gonçalves, Lourdes Zélia Garcia Zanoni, Valter Aragão do Nascimento
The present work describes a method to quantify the level of oxidative stress in infantile cardiac surgery. Fifteen patients, 6 girls and 9 boys, aged between 3 months and 16 years were divided into three groups. The first group sought to quantify the oxidative stress from differing concentrations of selenium. The second group used malondialdehyde as an indicator of oxidative stress. Finally, the third group quantified oxidative stress by normalizing the selenium concentration via malondialdehyde. Blood aliquots of 1...
May 12, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29753743/jlp-jnk-signaling-protects-cancer-cells-from-reactive-oxygen-species-induced-cell-death
#15
Rong Li, I Ketut Gunarta, Ryusuke Suzuki, Jambaldorj Boldbaatar, Ryota Nakazato, Dewi Yuliana, Gantulga Davaakhuu, Tsendsuren Oyunsuren, Nobuhiko Takamatsu, Masahiko Kobayashi, Atsushi Hirao, Katsuji Yoshioka
Oxidative stress, which can be caused by an overproduction of reactive oxygen species (ROS), often leads to cell death. In recent years, c-Jun NH2 -terminal kinase (JNK)-associated leucine zipper protein (JLP, also known as SPAG9 or JIP4), a scaffold protein for JNK mitogen-activated protein kinase (MAPK) signaling pathways, was found to serve as a novel biomarker for cancer. However, although JNK MAPK pathways are reported to be activated in response to various stimuli, including oxidative stress, whether JLP is involved in ROS signaling remains unknown...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29753722/naringin-protects-against-bone-loss-in-steroid-treated-inflammatory-bowel-disease-in-a-rat-model
#16
Chengli Li, Jun Zhang, Fang Lv, Xingtao Ge, Gang Li
We observed the effects of naringin on bone loss in glucocorticoid-treated inflammatory bowel disease (IBD) in a rat model. The IBD model was established in Sprague-Dawley rats by administering 5.0% dextran sodium sulfate. Dexamethasone (DEX) and naringin were given at the second week. Blood, colon and bone samples were collected for biomarker assay, histological analysis or microCT analysis. Superoxide dismutase, catalase and malonaldehyde were measured in bone. A significant decrease of procollagen type 1 N-terminal propeptide (P1NP) level was observed in DEX-treated IBD groups compared with the control (p < 0...
May 10, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29753289/native-crustacean-species-as-a-bioindicator-of-freshwater-ecosystem-pollution-a-multivariate-and-integrative-study-of-multi-biomarker-response-in-active-river-monitoring
#17
Lidwina Bertrand, Magdalena Victoria Monferrán, Catherine Mouneyrac, María Valeria Amé
The aim of this study was to evaluate the ability of Palaemonetes argentinus to evidence the environmental degradation due to pollutants mixture in a freshwater aquatic ecosystem. For this purpose, an active monitoring (96 h exposure) was carried out in seven sites along the Ctalamochita River basin (Córdoba, Argentina), as a case of study. Our results evidenced sewage discharges impact in the water quality index, as well as metal pollution in water (Ag, Al, B, Pb, Hg) and sediments (Hg) with a potential effect on aquatic biota...
May 4, 2018: Chemosphere
https://www.readbyqxmd.com/read/29753146/exposure-to-acrylamide-and-the-risk-of-cardiovascular-diseases-in-the-national-health-and-nutrition-examination-survey-2003-2006
#18
Yu Zhang, Mengmeng Huang, Pan Zhuang, Jingjing Jiao, Xinyu Chen, Jun Wang, Yongning Wu
BACKGROUND: Long-term exposure to acrylamide (AA) from diet sources may induce oxidative stress and chronic inflammation. However, the association between AA exposure and the prevalence of cardiovascular diseases (CVD) remains unclear. OBJECTIVES: We aimed to examine the association between blood exposure levels of AA biomarkers and the prevalence of main types of CVD in a general population of US adults. METHODS: We analyzed the associations between AA hemoglobin biomarkers [hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA), sum of HbAA and HbGA (HbAA+HbGA), and ratio of HbGA to HbAA (HbGA:HbAA)] and self-reported diagnosis of CVD in 8290 adults (≥20 years of age) from the National Health and Nutrition Examination Survey (NHANES) 2003-2006...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29752960/assessment-of-herb-drug-synergy-to-combat-doxorubicin-induced-cardiotoxicity
#19
Aditi Jain, Vibha Rani
Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potential in this regard. Curcuma longa (an Indian herb) polyphenols including curcumin, and well known for its anti-oxidative and anti-cancerous potential was used in the present study for its synergistic effect on cancer cells and cardiomyocytes...
May 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29752628/correlation-between-heat-shock-proteins-adiponectin-and-t-lymphocyte-cytokine-expression-in-type-2-diabetics
#20
Fadia F Mahmoud, David Haines, Ali A Dashti, Sherief El-Shazly, Fawzia Al-Najjar
Type 2 diabetes mellitus (T2DM) features insulin resistance, hyperglycemia, dyslipidemia, overproduction of inflammatory cytokines, and systemic oxidative stress. Here, heat shock proteins Hsp70 and Hsp 90, adiponectin, and heme oxygenase-1 (HO-1, Hsp32) are profiled in peripheral blood mononuclear cells (PBMC) and serum from 25 T2DM patients and 25 healthy control subjects. Cells cultured with phorbol 12-myristate 13-acetate/ionomycin were evaluated by three-color flow cytometry for immunophenotypic biomarkers...
May 11, 2018: Cell Stress & Chaperones
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