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https://www.readbyqxmd.com/read/27879158/potential-of-lysophosphatidylinositol-as-a-prognostic-indicator-of-cardiac-arrest-using-a-rat-model
#1
Junhwan Kim, Tai Yin, Koichiro Shinozaki, Joshua W Lampe, Lance B Becker
AIMS: The potential of a lysophosphatidylinositol species, LPI(18:0), as an biomarker of ischaemia was tested using a rat model of cardiac arrest (CA). METHODS: Male Sprague-Dawley rats were subjected to asphyxia-induced CA or CA followed by cardiopulmonary bypass (CPB) resuscitation. Brain, heart, kidney, and liver tissues were harvested from rats after 0, 5, 10, 20, 30, and 60 min CA and 30 min CA followed by 60 min CPB resuscitation. Blood samples were collected from inferior vena cava and hepatic veins following 30 min CA...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27862979/cerebral-tissue-oxygenation-index-and-lactate-at-24-hours-postoperative-predict-survival-and-neurodevelopmental-outcome-after-neonatal-cardiac-surgery
#2
Safwat A Aly, David Zurakowski, Penny Glass, Kami Skurow-Todd, Richard A Jonas, Mary T Donofrio
IMPORTANCE: There are no well-established noninvasive biomarkers for identifying patients at risk for poor outcome after surgery for congenital heart disease. Few studies have assessed prognostic accuracy of cerebral tissue oxygenation index (cTOI) measured by near infrared spectroscopy (NIRS). OBJECTIVE: To assess the utility of noninvasive NIRS monitoring as a predictor of outcomes after neonatal cardiac surgery through measurement of cTOI. To examine the utility of noninvasive NIRS monitoring in combination with lactate concentration and inotropic score in prediction of outcomes after neonatal cardiac surgery...
November 10, 2016: Congenital Heart Disease
https://www.readbyqxmd.com/read/27648690/time-course-of-cd64-a-leukocyte-activation-marker-during-cardiopulmonary-bypass-surgery
#3
Sarah Djebara, Patrick Biston, Emmanuel Fossé, Anne Daper, Marc Joris, Karim Zouaoui Boudjeltia, Christophe Lelubre, Philippe Cauchie, Michael Piagnerelli
Distinction between inflammation secondary to surgery, especially coronary artery bypass graft with cardiopulmonary bypass (CPB), and inflammation due to infection is difficult in surgical intensive care unit (ICU) patients. Development of biomarkers of infection could help clinicians in the early identification and thus treatment of sepsis in these patients. We compared the time course of the neutrophil CD64 index, a high affinity immunoglobulin FC γ receptor I whose expression is increased in bacterial infection, in 39 patients undergoing cardiac surgery with CPB and 11 patients admitted to the ICU with severe sepsis or septic shock...
September 19, 2016: Shock
https://www.readbyqxmd.com/read/27404222/a-multicenter-randomized-controlled-phase-iib-trial-of-avoidance-of-hyperoxemia-during-cardiopulmonary-bypass
#4
Shay P McGuinness, Rachael L Parke, Kate Drummond, Tim Willcox, Michael Bailey, Cornelius Kruger, Megan Baker, Keri-Anne Cowdrey, Eileen Gilder, Lianne McCarthy, Thomas Painter
BACKGROUND: Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. Cardiac surgery-associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. Pathophysiology of CSA-MOD involves numerous injurious pathways linked to the use of CPB including oxidative stress and formation of reactive iron species. During cardiac surgery with CPB, arterial return blood is oxygenated to supranormal levels...
September 2016: Anesthesiology
https://www.readbyqxmd.com/read/27397448/short-term-prognostic-value-of-perioperative-coronary-sinus-derived-serum-cardiac-troponin-i-creatine-kinase-mb-lactate-pyruvate-and-lactate-pyruvate-ratio-in-adult-patients-undergoing-open-heart-surgery
#5
Ujjwal Kumar Chowdhury, Avneesh Sheil, Poonam Malhotra Kapoor, Rajiv Narang, Parag Gharde, Vishwas Malik, Mani Kalaivani, Arindam Chaudhury
OBJECTIVES: To investigate the release pattern of different cardiac metabolites and biomarkers directly from the coronary sinus (CS) and to establish the diagnostic discrimination limits of each marker protein and metabolites to evaluate perioperative myocardial injury in patients undergoing cardiac surgery under cardiopulmonary bypass (CPB). PATIENTS AND METHODS: Sixty-eight patients undergoing first mitral and/or aortic valve replacements with/without coronary artery bypass grafting and Bentall procedure under CPB and blood cardioplegic arrest were studied...
July 2016: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/27357468/circulating-histones-for-predicting-prognosis-after-cardiac-surgery-a-prospective-study
#6
Hongxiang Gao, Naipu Zhang, Fangfang Lu, Xindi Yu, Limin Zhu, Xi Mo, Wei Wang
OBJECTIVES: The objective of this study was to assess the perioperative changes in circulating histones and their relationships with other biomarkers and clinical outcomes after cardiac surgery with cardiopulmonary bypass (CPB) in patients. METHODS: Forty-eight patients with congenital cardiac diseases undergoing corrective procedure with CPB were prospectively enrolled in this study. Circulating histones, N-terminal pro-brain natriuretic peptide (NT-proBNP), procalcitonin (PCT) and C-reactive protein (CRP) were measured preoperatively (T0) and at 0 (T1), 24 (T2), 48 (T3) and 72 (T4) h postoperatively...
November 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27316657/association-of-nadir-oxygen-delivery-on-cardiopulmonary-bypass-with-serum-glial-fibrillary-acid-protein-levels-in-paediatric-heart-surgery-patients
#7
J Trent Magruder, Narutoshi Hibino, Sarah Collica, Huaitao Zhang, H Lynn Harness, Eugenie S Heitmiller, Marshall L Jacobs, Duke E Cameron, Luca A Vricella, Allen D Everett
OBJECTIVES: Protecting the brain during cardiac surgery is a major challenge. We evaluated associations between nadir oxygen delivery (DO2) during paediatric cardiac surgery and a biomarker of brain injury, glial fibrillary acidic protein (GFAP). METHODS: Blood samples were obtained during a prospective, single-centre observational study of children undergoing congenital heart surgery with cardiopulmonary bypass (CPB) (2010-2011). Remnant blood samples, collected serially prior to cannulation for bypass and until incision closure, were analysed for GFAP levels...
October 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27212844/procalcitonin-as-a-biomarker-of-bacterial-infection-in-pediatric-patients-after-congenital-heart-surgery
#8
Sujata B Chakravarti, Diane A Reformina, Timothy M Lee, Sunil P Malhotra, Ralph S Mosca, Puneet Bhatla
BACKGROUND: Bacterial infection (BI) after congenital heart surgery (CHS) is associated with increased morbidity and is difficult to differentiate from systemic inflammatory response syndrome caused by cardiopulmonary bypass (CPB). Procalcitonin (PCT) has emerged as a reliable biomarker of BI in various populations. AIM: To determine the optimal PCT threshold to identify BI among children suspected of having infection following CPB. SETTING AND DESIGN: Single-center retrospective observational study...
May 2016: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/27142905/key-points-for-curbing-cardiopulmonary-bypass-inflammation
#9
Paulo Roberto Barbosa Evora, Camila Bottura, Livia Arcêncio, Agnes Afrodite Sumarelli Albuquerque, Patrícia Martinez Évora, Alfredo José Rodrigues
PURPOSE: Cardiopulmonary bypass (CPB) procedures are thought to activate systemic inflammatory reaction syndrome (SIRS). Strategies to curb systemic inflammation have been previously described. However, none of them is adequate, since "curbing" the extent of the inflammatory response requires a multimodal approach. The aim of the present mini-review is to discuss the main key points about the main principles in cardiopulmonary bypass curbing inflammation. METHODS: No systematic literature search (MEDLINE) and extracted data from the accumulated experience of the authors...
2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27026925/plasma-level-of-advanced-oxidation-protein-products-as-a-novel-biomarker-of-acute-lung-injury-following-cardiac-surgery
#10
Songlin Du, Jun Ai, Xiangzhen Zeng, Jun Wan, Xu Wu, Jianxing He
This study was designed to test the hypothesis that whether the plasma level of advanced oxidant protein products (AOPPs) would be useful for the clinical diagnosis of acute lung injury (ALI) following cardiac surgery with the technique of cardiopulmonary bypass (CPB). In this prospective study, seventy consecutive adults undergoing open heart surgery with CPB were included and assigned into the ALI (n = 18) and non-ALI (n = 52) groups according to the American-European Consensus Criteria. Plasma concentrations of AOPPs were measured at baseline, postoperative 1 h, 12 h, 24 h, and 48 h...
2016: SpringerPlus
https://www.readbyqxmd.com/read/26999704/perioperative-kinetics-of-endocan-in-patients-undergoing-cardiac-surgery-with-and-without-cardiopulmonary-bypass
#11
Pradeep R Madhivathanan, Nick Fletcher, David Gaze, Rebekah Thomson, Venkatachalam Chandrasekaran, Nawaf Al-Subaie, Oswaldo Valencia, Vivek Sharma
INTRODUCTION: Endothelial Specific Molecule-1 or endocan is a novel biomarker associated with the development of acute lung injury (ALI) in response to a systemic inflammatory state such as trauma. Acute Respiratory Distress syndrome (ARDS), a severe form of ALI is a devastating complication that can occur following cardiac surgery due to risk factors such as the use of cardiopulmonary bypass (CPB) during surgery. In this study we examine the kinetics of endocan in the perioperative period in cardiac surgical patients...
July 2016: Cytokine
https://www.readbyqxmd.com/read/26982887/evaluation-of-serum-cysteine-rich-protein-61-and-cystatin-c-levels-for-assessment-of-acute-kidney-injury-after-cardiac-surgery
#12
Osama F Mosa, Milan Skitek, Jurij M Kalisnik, Ales Jerin
Objective The occurrence of acute kidney injury (AKI) after cardiopulmonary bypass (CPB) can lead to morbidity and mortality. We hypothesized that cysteine-rich protein 61 (CYR61) and cystatin C (CysC) may be potential novel biomarkers of AKI after cardiopulmonary bypass. Methods Patients were classified into AKI and non-AKI group depending on serum creatinine. Levels of creatinine, CysC, and CYR61 were measured at five time-points before and within 48 h after the surgery. Results Fifty patients were included in the study...
June 2016: Renal Failure
https://www.readbyqxmd.com/read/26871797/effects-of-heart-bypass-surgery-on-plasma-a%C3%AE-40-and-a%C3%AE-42-levels-in-infants-and-young-children
#13
Yaoqin Hu, Shanshan Shi, Xiwang Liu, Zhiyong Hu, Wenfang Huang, Dongpi Wang, Jianguo Xu, Baoli Cheng, Xiangming Fang, Qiang Shu
Accumulation of β-amyloid (Aβ) plaques is a pathological hallmark of Alzheimer disease. Aβ levels in animals and adults were reported to be associated with postoperative cognitive dysfunction (POCD). Our goal was to determine the plasma levels of Aβ in infants and young children after cardiac surgery with cardiopulmonary bypass (CPB).Forty-two infants and young children aged from 1 to 35 months undergoing cardiac surgery with general anesthetics were prospectively enrolled from January to June 2014 at a tertiary medical center...
February 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26827702/proenkefalin-a-and-protachykinin-in-ischemic-neurological-complications-after-cardiac-surgery
#14
Milan Skitek, Aleš Jerin
AIM: The evaluation of biomarkers of acute ischemic brain injury following surgical revascularization of the heart with the use of the heart-lung machine (cardiopulmonary bypass, CPB). METHODS: Twenty consecutive patients were divided into two groups: the first 10 patients received a potential neuroprotective human recombinant erythropoietin, while the remaining 10 comprised the control group. Neurological complications were monitored by measuring serum concentrations of neuropeptide proenkephalin A(PENK-A) and protachykinin A (PTA) before and in the first 5 days after surgery, comparing the neurological outcome with MRI examinations...
February 1, 2016: Medicinski Glasnik
https://www.readbyqxmd.com/read/26675556/green-tea-polyphenol-prevents-diabetic-rats-from-acute-kidney-injury-after-cardiopulmonary-bypass
#15
Masaki Funamoto, Hidetoshi Masumoto, Koji Takaori, Tomofumi Taki, Shuji Setozaki, Kazuhiro Yamazaki, Kenji Minakata, Tadashi Ikeda, Suong-Hyu Hyon, Ryuzo Sakata
BACKGROUND: Acute kidney injury (AKI) is a common complication accompanying cardiopulmonary bypass (CPB) and is independently associated with increased morbidity and death. Diabetes mellitus increases the risk for AKI after CPB. Epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, which possesses cardioprotective activities, as previously reported. We hypothesized that EGCG also possesses a renoprotective effect through its diverse biochemical properties and assessed the effect on renal function after CPB for diabetic rats...
April 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26366890/vasopressinase-activity-a-potential-early-biomarker-for-detecting-cardiopulmonary-bypass-associated-acute-kidney-injury
#16
Namhee Kim, Si Yuan Dai, Victoria Pang, C David Mazer
Background Acute kidney injury (AKI) is a common and serious complication of surgeries that include cardiopulmonary bypass (CPB). Currently, increases in serum creatinine levels are used to diagnose AKI, but this change may be slow to detect. Animal studies pertaining to renal hypoxia suggest a correlation between vasopressinase activity and AKI. The objective of this study is to determine if vasopressinase activity can be used as an early biomarker for renal hypoxia and CPB-associated AKI. This could potentially help improve the diagnosis and subsequent treatment of the condition...
October 2016: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/26336475/prognostic-value-of-scd14-st-presepsin-in-cardiac-surgery
#17
Dmitry Popov, Marina Plyushch, Svetlana Ovseenko, Marina Abramyan, Olga Podshchekoldina, Mikhail Yaroustovsky
INTRODUCTION: Prediction of complications and mortality after cardiac surgery is an important aspect of timely correction of these conditions. One possibility in this case is the use of biomarkers and some prognostic scores. AIM OF THE STUDY: To study the prognostic value of presepsin (PSP) as a predictor of postoperative complications development in cardiosurgical patients. MATERIAL AND METHODS: Patients operated for acquired heart diseases with cardiopulmonary bypass (CPB) were included in the study (n = 51, age: 58 ± 11 years)...
March 2015: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/26228605/prolonged-white-matter-inflammation-after-cardiopulmonary-bypass-and-circulatory-arrest-in-a-juvenile-porcine-model
#18
Ludmila Korotcova, Sonali Kumar, Kota Agematsu, Paul D Morton, Richard A Jonas, Nobuyuki Ishibashi
BACKGROUND: White matter (WM) injury is common after neonatal cardiopulmonary bypass (CPB). We have demonstrated that the inflammatory response to CPB is an important mechanism of WM injury. Microglia are brain-specific immune cells that respond to inflammation and can exacerbate injury. We hypothesized that microglia activation contributes to WM injury caused by CPB. METHODS: Juvenile piglets were randomly assigned to 1 of 3 CPB-induced brain insults (1, no-CPB; 2, full-flow CPB; 3, CPB and circulatory arrest)...
September 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26180514/serum-uch-l1-as-a-novel-biomarker-to-predict-neuronal-apoptosis-following-deep-hypothermic-circulatory-arrest
#19
Ya-Ping Zhang, Yao-Bin Zhu, Dayue Darrel Duan, Xiang-Ming Fan, Yan He, Jun-Wu Su, Ying-Long Liu
BACKGROUND: Deep hypothermic circulatory arrest (DHCA) has been used in cardiac surgery involving infant complex congenital heart disease and aortic dissection. DHCA carries a risk of neuronal apoptotic death in brain. Serum ubiquitin C-terminal hydrolase L1 (UCH-L1) level is elevated in a number of neurological diseases involving neuron injury and death. We studied the hypothesis that UCH-L1 may be a potential biomarker for DHCA-induced ischemic neuronal apoptosis. METHODS: Anesthetized piglets were used to perform cardiopulmonary bypass (CPB)...
2015: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/26163357/rewarming-rate-during-cardiopulmonary-bypass-is-associated-with-release-of-glial-fibrillary-acidic-protein
#20
Daijiro Hori, Allen D Everett, Jennifer K Lee, Masahiro Ono, Charles H Brown, Ashish S Shah, Kaushik Mandal, Joel E Price, Laeben C Lester, Charles W Hogue
BACKGROUND: Rewarming from hypothermia during cardiopulmonary bypass (CPB) may compromise cerebral oxygen balance, potentially resulting in cerebral ischemia. The purpose of this study was to evaluate whether CPB rewarming rate is associated with cerebral ischemia assessed by the release of the brain injury biomarker glial fibrillary acidic protein (GFAP). METHODS: Blood samples were collected from 152 patients after anesthesia induction and after CPB for the measurement of plasma GFAP levels...
October 2015: Annals of Thoracic Surgery
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