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Biomarkers neurological damage

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https://www.readbyqxmd.com/read/27920793/cognitive-decline-in-patients-with-chronic-hydrocephalus-and-normal-aging-growing-into-deficits
#1
Marlijn H de Beer, Philip Scheltens
BACKGROUND/AIM: To explore the theory of 'growing into deficits', a concept known from developmental neurology, in a series of cases with chronic hydrocephalus (CH). METHODS: Patients were selected from the Amsterdam Dementia Cohort and underwent extensive dementia screening. RESULTS: Twelve patients with CH were selected, in whom Alzheimer's disease was considered unlikely, based on biomarker information and follow-up. Mean Mini-Mental State Examination score was 24 (range 7-30)...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27903281/improving-the-clinical-management-of-traumatic-brain-injury-through-the-pharmacokinetic-modeling-of-peripheral-blood-biomarkers
#2
Aaron Dadas, Jolewis Washington, Nicola Marchi, Damir Janigro
BACKGROUND: Blood biomarkers of neurovascular damage are used clinically to diagnose the presence severity or absence of neurological diseases, but data interpretation is confounded by a limited understanding of their dependence on variables other than the disease condition itself. These include half-life in blood, molecular weight, and marker-specific biophysical properties, as well as the effects of glomerular filtration, age, gender, and ethnicity. To study these factors, and to provide a method for markers' analyses, we developed a kinetic model that allows the integrated interpretation of these properties...
November 30, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27889229/brown-propolis-attenuates-cerebral-ischemia-induced-oxidative-damage-via-affecting-antioxidant-enzyme-system-in-mice
#3
Gholamreza Bazmandegan, Mohammad Taher Boroushaki, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Allahtavakoli
Oxidative stress plays a critical role in ischemic brain injury. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) are the enzymes underlying the endogenous antioxidant mechanisms affected by stroke and are considered as oxidative stress biomarkers. Brown propolis (BP) is a bioactive natural product with a set of biological activities that in turn may differ depending on the area from which the substance is originated. The aim of this study was to investigate the effect of water-extracted brown propolis (WEBPs), from two regions of Iran, against cerebral ischemia-induced oxidative injury in a mouse model of stroke...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27888142/profiling-and-identification-of-new-proteins-involved-in-brain-ischemia-using-maldi-imaging-mass-spectrometry
#4
Víctor Llombart, Sebastián Alejandro Trejo, Sílvia Bronsoms, Anna Morancho, Ma Feifei, Júlia Faura, Teresa García-Berrocoso, Alba Simats, Anna Rosell, Francesc Canals, Mar Hernández-Guillamón, Joan Montaner
: The identification of proteins involved in brain ischemia might allow the discovery of putative biomarkers or therapeutic targets for ischemic stroke. Our aim is to study the distribution of proteins within mouse brain after an ischemic insult using MALDI imaging-mass-spectrometry and to identify relevant proteins involved in brain damage. We occluded the middle cerebral artery of C57BL/6J mice. Brain slices were analyzed by MALDI-TOF and infarct (IC) and contralateral (CL) regions were compared using ClinProTools...
November 22, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27821249/protein-carbonyl-content-a-novel-biomarker-for-aging-in-hiv-aids-patients
#5
Vaishali Kolgiri, Vinayak Wamanrao Patil
BACKGROUND: The major complications of "treated" Human Immunodeficiency Virus (HIV) infection are cardiovascular disease, malignancy, renal disease, liver disease, bone disease, and perhaps neurological complications, which are phenomena of the normal aging process occurring at an earlier age in the HIV-infected population. The present study is aimed to explore protein carbonyl content as a biomarker for detecting oxidative DNA damage induced ART toxicity and/or accelerated aging in HIV/AIDS patients...
November 4, 2016: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27794524/progressive-multiple-sclerosis-from-pathogenic-mechanisms-to-treatment
#6
Jorge Correale, María I Gaitán, María C Ysrraelit, Marcela P Fiol
During the past decades, better understanding of relapsing-remitting multiple sclerosis disease mechanisms have led to the development of several disease-modifying therapies, reducing relapse rates and severity, through immune system modulation or suppression. In contrast, current therapeutic options for progressive multiple sclerosis remain comparatively disappointing and challenging. One possible explanation is a lack of understanding of pathogenic mechanisms driving progressive multiple sclerosis. Furthermore, diagnosis is usually retrospective, based on history of gradual neurological worsening with or without occasional relapses, minor remissions or plateaus...
October 29, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27793019/intravenous-administration-of-xenogenic-adipose-derived-mesenchymal-stem-cells-admsc-and-admsc-derived-exosomes-markedly-reduced-brain-infarct-volume-and-preserved-neurological-function-in-rat-after-acute-ischemic-stroke
#7
Kuan-Hung Chen, Chih-Hung Chen, Christopher Glenn Wallace, Chun-Man Yuen, Gour-Shenq Kao, Yi-Ling Chen, Pei-Lin Shao, Yung-Lung Chen, Han-Tan Chai, Kun-Chen Lin, Chu-Feng Liu, Hsueh-Wen Chang, Mel S Lee, Hon-Kan Yip
We tested the hypothesis that combined xenogenic (from mini-pig) adipose-derived mesenchymal stem cell (ADMSC) and ADMSC-derived exosome therapy could reduce brain-infarct zone (BIZ) and enhance neurological recovery in rat after acute ischemic stroke (AIS) induced by 50-min left middle cerebral artery occlusion. Adult-male Sprague-Dawley rats (n = 60) were divided equally into group 1 (sham-control), group 2 (AIS), group 3 [AIS-ADMSC (1.2×106 cells)], group 4 [AIS-exosome (100μg)], and group 5 (AIS-exosome-ADMSC)...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27623176/micrornas-modulate-the-purinergic-signaling-network
#8
Davide Ferrari, Nicoletta Bianchi, Holger K Eltzschig, Roberto Gambari
MicroRNAs (miRNAs) are small non-coding RNA molecules capable of silencing mRNA targets. miRNA dysregulation has been linked to cancer development, cardiovascular and neurological diseases, lipid metabolism, and impaired immunity. Therefore, miRNAs are gaining interest as putative novel disease biomarkers and therapeutic targets. Recent studies have shown that purinergic surface receptors activated by extracellular nucleotides (ATP, ADP, UTP, UDP), and by nucleosides such as adenosine (ADO), are subject to miRNA regulation...
October 2016: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/27589522/combining-cerebrospinal-fluid-biomarkers-and-neuropsychological-assessment-a%C3%A2-simple-and-cost-effective-algorithm-to%C3%A2-predict-the-progression-from-mild-cognitive-impairment-to-alzheimer-s-disease-dementia
#9
Salvatore Mazzeo, Roberto Santangelo, Maria Paola Bernasconi, Giordano Cecchetti, Agnese Fiorino, Patrizia Pinto, Gabriella Passerini, Monica Falautano, Giancarlo Comi, Giuseppe Magnani
BACKGROUND: Correctly diagnosing Alzheimer's disease (AD) in prodromal phases would allow the adoption of experimental therapeutic strategies that could selectively interrupt the pathogenetic process before neuronal damage becomes irreversible. Therefore, great efforts have been aimed at finding early reliable disease markers. OBJECTIVE: The aim of this study was to identify a simple, cost effective, and reliable diagnostic algorithm to predict conversion from mild cognitive impairment (MCI) to AD...
October 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27588567/lipid-peroxidation-and-tyrosine-nitration-in-traumatic-brain-injury-insights-into-secondary-injury-from-redox-proteomics
#10
REVIEW
D Allan Butterfield, Tanea T Reed
Traumatic brain injury (TBI) is a spontaneous event in which sudden trauma and secondary injury cause brain damage. Symptoms of TBI can range from mild to severe depending on extent of injury. The outcome can span from complete patient recovery to permanent memory loss and neurological decline. Currently, there is no known cure for TBI; however, immediate medical attention after injury is most beneficial for patient recovery. It is a well-established concept that imbalances in the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and native antioxidant mechanisms have been shown to increase oxidative stress...
September 2, 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27555377/minocycline-a-putative-neuroprotectant-co-administered-with-doxorubicin-cyclophosphamide-chemotherapy-in-a-xenograft-model-of-triple-negative-breast-cancer
#11
Lauren E Himmel, Maryam B Lustberg, A Courtney DeVries, Ming Poi, Ching-Shih Chen, Samuel K Kulp
Minocycline is purported to have neuroprotective properties in experimental models of some human neurologic diseases, and has therefore been identified as a putative neuroprotectant for chemotherapy-induced cognitive impairment (CICI) in breast cancer patients. However, because its mechanism of action is believed to be mediated through anti-inflammatory, anti-apoptotic, and anti-oxidant pathways, co-administration of minocycline with chemotherapeutic agents has the potential to reduce the efficacy of anticancer drugs...
October 2016: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/27538777/blood-brain-biomarkers-of-inflammation-after-stroke-and-their-association-with-outcome-from-c-reactive-protein-to-damage-associated-molecular-patterns
#12
REVIEW
Alejandro Bustamante, Alba Simats, Andrea Vilar-Bergua, Teresa García-Berrocoso, Joan Montaner
Stroke represents one of the most important causes of disability and death in developed countries. However, there is a lack of prognostic tools in clinical practice to monitor the neurological condition and predict the final outcome. Blood biomarkers have been proposed and studied in this indication; however, no biomarker is currently used in clinical practice. The stroke-related neuroinflammatory processes have been associated with a poor outcome in stroke, as well as with poststroke complications. In this review, we focus on the most studied blood biomarkers of this inflammatory processes, cytokines, and C-reactive protein, evaluating its association with outcome and complications in stroke through the literature, and performing a systematic review on the association of C-reactive protein and functional outcome after stroke...
October 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27522459/proinflammatory-cytokines-enolase-and-s-100-as-early-biochemical-indicators-of-hypoxic-ischemic-encephalopathy-following-perinatal-asphyxia-in-newborns
#13
Verónica Chaparro-Huerta, Mario Eduardo Flores-Soto, Mario Ernesto Merin Sigala, Juan Carlos Barrera de León, María de Lourdes Lemus-Varela, Blanca Miriam de Guadalupe Torres-Mendoza, Carlos Beas-Zárate
BACKGROUND: Estimation of the neurological prognosis of infants suffering from perinatal asphyxia and signs of hypoxic-ischemic encephalopathy is of great clinical importance; however, it remains difficult to satisfactorily assess these signs with current standard medical practices. Prognoses are typically based on data obtained from clinical examinations and neurological tests, such as electroencephalography (EEG) and neuroimaging, but their sensitivities and specificities are far from optimal, and they do not always reliably predict future neurological sequelae...
May 31, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27519416/novel-mouse-models-of-methylmalonic-aciduria-recapitulate-phenotypic-traits-with-a-genetic-dosage-effect
#14
Patrick Forny, Anke Schumann, Merima Mustedanagic, Déborah Mathis, Marie-Angela Wulf, Nadine Nägele, Claus-Dieter Langhans, Assem Zhakupova, Joerg Heeren, Ludger Scheja, Ralph Fingerhut, Heidi L Peters, Thorsten Hornemann, Beat Thony, Stefan Kölker, Patricie Burda, D Sean Froese, Olivier Devuyst, Matthias R Baumgartner
Methylmalonic aciduria (MMAuria), caused by deficiency of methylmalonyl-CoA mutase (MUT), usually presents in the newborn period with failure to thrive and metabolic crisis leading to coma or even death. Survivors remain at risk of metabolic decompensations and severe long term complications, notably renal failure and neurological impairment. We generated clinically relevant mouse models of MMAuria using a constitutive Mut knock-in (KI) allele based on the p.Met700Lys patient mutation, used homozygously (KI/KI) or combined with a knockout allele (KO/KI), to study biochemical and clinical MMAuria disease aspects...
September 23, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27458972/altered-blood-biomarker-profiles-in-athletes-with-a-history-of-repetitive-head-impacts
#15
Alex P Di Battista, Shawn G Rhind, Doug Richards, Nathan Churchill, Andrew J Baker, Michael G Hutchison
The long-term health effects of concussion and sub-concussive impacts in sport are unknown. Growing evidence suggests both inflammation and neurodegeneration are pivotal to secondary injury processes and the etiology of neurodegenerative diseases. In the present study we characterized circulating brain injury and inflammatory mediators in healthy male and female athletes according to concussion history and collision sport participation. Eighty-seven university level athletes (male, n = 60; female, n = 27) were recruited before the start of the competitive season...
2016: PloS One
https://www.readbyqxmd.com/read/27452210/prospects-of-modeling-poststroke-epileptogenesis
#16
Doodipala Samba Reddy, Aamir Bhimani, Ramkumar Kuruba, Min Jung Park, Farida Sohrabji
This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke. Nevertheless, the overall prevalence of PSE is 2-4%. Rodent models of stroke have contributed to our understanding of the relationship between seizures and the underlying ischemic damage to neurons. To understand whether acutely generated stroke events lead to a chronic phenotype more closely resembling PSE with recurrent seizures, a limited variety of approaches emerged in early 2000s...
July 25, 2016: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/27404222/a-multicenter-randomized-controlled-phase-iib-trial-of-avoidance-of-hyperoxemia-during-cardiopulmonary-bypass
#17
Shay P McGuinness, Rachael L Parke, Kate Drummond, Tim Willcox, Michael Bailey, Cornelius Kruger, Megan Baker, Keri-Anne Cowdrey, Eileen Gilder, Lianne McCarthy, Thomas Painter
BACKGROUND: Cardiac surgery utilizing cardiopulmonary bypass (CPB) is one of the most common forms of major surgery. Cardiac surgery-associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. Pathophysiology of CSA-MOD involves numerous injurious pathways linked to the use of CPB including oxidative stress and formation of reactive iron species. During cardiac surgery with CPB, arterial return blood is oxygenated to supranormal levels...
September 2016: Anesthesiology
https://www.readbyqxmd.com/read/27386506/absence-of-systemic-oxidative-stress-and-increased-csf-prostaglandin-f2%C3%AE-in-progressive-ms
#18
Magda A Lam, Ghassan J Maghzal, Mohsen Khademi, Fredik Piehl, Rikke Ratzer, Jeppe Romme Christensen, Finn Thorup Sellebjerg, Tomas Olsson, Roland Stocker
OBJECTIVE: We aimed to investigate the role of oxidative stress in the progression of multiple sclerosis (MS). METHODS: We determined by liquid chromatography-tandem mass spectrometry nonenzymatic (F2-isoprostanes) and enzymatic oxidation products of arachidonic acid (prostaglandin F2α [PGF2α]) in plasma and CSF of 45 controls (other neurologic disease [OND] with no signs of inflammation) and 62 patients with MS. Oxidation products were correlated with disease severity and validated biomarkers of inflammation (chemokine ligand 13; matrix metalloproteinase-9; osteopontin) and axonal damage (neurofilament light protein)...
August 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27375151/intravascular-lymphoma-mimicking-multiple-sclerosis
#19
Grzegorz Kloc, Małgorzata Budziak, Agnieszka Więckiewicz, Mateusz Pleśniak, Halina Bartosik-Psujek
Diagnosis of relapsing-remitting multiple sclerosis requires demonstration disseminated symptoms in time and space on the basis of neurological assessment or magnetic resonance imaging findings. In addition, the diagnosis is conditioned by ruling out other conditions that may explain the clinical symptoms. We describe the patient presenting in the initial stage of the disease neurological symptoms and magnetic resonance imaging lesions, that met criteria for relapsing-remitting multiple sclerosis diagnosis...
July 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27296840/preliminary-case-control-study-to-establish-the-correlation-between-novel-peroxidation-biomarkers-in-cord-serum-and-the-severity-of-hypoxic-ischemic-encephalopathy
#20
Consuelo Chafer-Pericas, María Cernada, Leena Rahkonen, Vedran Stefanovic, Sture Andersson, Máximo Vento
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) has deleterious neurological consequences. To identify patients at risk of neuronal damage deserving implementation of neuroprotective strategies clinicians have relied on prenatal sentinel events, postnatal clinical assessment (Apgar score), and blood gas analysis. This feasibility study aimed to assess if lipid peroxidation byproducts associated with neuronal damage correlated with cord blood metabolic acidemia in patients with HIE. POPULATION AND METHODS: This is a case/control study in which cases were newborn infants with severe acidemia (pH<7...
August 2016: Free Radical Biology & Medicine
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