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https://www.readbyqxmd.com/read/28210202/mechanisms-and-effects-of-transcranial-direct-current-stimulation
#1
James Giordano, Marom Bikson, Emily S Kappenman, Vincent P Clark, H Branch Coslett, Michael R Hamblin, Roy Hamilton, Ryan Jankord, Walter J Kozumbo, R Andrew McKinley, Michael A Nitsche, J Patrick Reilly, Jessica Richardson, Rachel Wurzman, Edward Calabrese
The US Air Force Office of Scientific Research convened a meeting of researchers in the fields of neuroscience, psychology, engineering, and medicine to discuss most pressing issues facing ongoing research in the field of transcranial direct current stimulation (tDCS) and related techniques. In this study, we present opinions prepared by participants of the meeting, focusing on the most promising areas of research, immediate and future goals for the field, and the potential for hormesis theory to inform tDCS research...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28186868/effects-of-near-infrared-light-on-cerebral-bioenergetics-measured-with-phosphorus-magnetic-resonance-spectroscopy
#2
Dionyssios Mintzopoulos, Timothy E Gillis, Clark E Tedford, Marc J Kaufman
OBJECTIVE: Cerebral photobiomodulation (PBM) improves mood and cognition. Cerebral metabolic enhancement is a mechanism proposed to underlie PBM effects. No PBM studies to date have applied phosphorus magnetic resonance spectroscopy ((31)P MRS), which can be used to assess metabolic intermediates such as phosphocreatine (PCr) and adenosine triphosphate, the latter of which is elevated by PBM. Accordingly, we used 9.4 Tesla (31)P MRS to characterize effects of single and repeat cerebral PBM treatments on metabolism...
February 9, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28178891/up-regulation-of-cerebral-cytochrome-c-oxidase-and-hemodynamics-by-transcranial-infrared-laser-stimulation-a-broadband-near-infrared-spectroscopy-study
#3
Xinlong Wang, Fenghua Tian, Divya D Reddy, Sahil S Nalawade, Douglas W Barrett, Francisco Gonzalez-Lima, Hanli Liu
Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28161015/-electrophysiological-testing-in-spinal-cord-tumors
#4
REVIEW
N André-Obadia, F Mauguière
Evoked potentials (EPs) are useful to evaluate the functional impairment of motor and somatosensory pathways in spinal cord tumors. Conduction through pyramidal tracts is evaluated by motor EPs (MEPs) elicited by transcranial stimulation, magnetic for awake patients or electric in the operating room. Somatosensory EPs (SEPs) and laser EPs (LEPs) are complementary procedures to explore conduction in dorsal columns and spinothalamic tracts, respectively. MEPs as well as SEPs show conduction abnormalities in about 60% of cases with a sensitivity that increases up to 70% when both procedures are carried out...
February 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28110588/neuroprotective-effects-of-adjunctive-treatments-for-acute-stroke-thrombolysis-a-review-of-clinical-evidence
#5
Hongxing Zhou, Suyun Huang, Gavin Sunnassee, Weiyu Guo, Jian Chen, Yang Guo, Sheng Tan
The narrow therapeutic time window and risk of intracranial hemorrhage largely restrict the clinical application of thrombolysis in acute ischemic stroke. Adjunctive treatments added to rt-PA may be beneficial to improve the capacity of neural cell to withstand ischemia, and to reduce the hemorrhage risk as well. This review aims to evaluate the neuroprotective effects of adjunctive treatments in combination with thrombolytic therapy for acute ischemic stroke. Relevant studies were searched in the PubMed, Web of Science, and EMBASE database...
January 23, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28096104/recent-developments-in-the-surgical-management-of-paediatric-epilepsy
#6
REVIEW
Vijay M Ravindra, Matthew T Sweney, Robert J Bollo
Among the 1% of children affected by epilepsy, failure of pharmacological therapy and early age of seizure onset can lead to worse long-term cognitive outcomes, mental health disorders and impaired functional status. Surgical management often improves functional and cognitive outcomes in children with medically refractory epilepsy, especially when seizure remission is achieved. However, surgery remains underused in children with drug-resistant epilepsy, creating a large treatment gap. Several recent innovations have led to considerable improvement in surgical technique, including the recent development of minimally invasive diagnostic and therapeutic techniques such as stereotactic EEG, transcranial magnetic stimulation, MRI-guided laser ablation, as well as novel paradigms of neurostimulation...
January 17, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28039085/transcranial-infrared-laser-stimulation-improves-rule-based-but-not-information-integration-category-learning-in-humans
#7
Nathaniel J Blanco, Celeste L Saucedo, F Gonzalez-Lima
This is the first randomized, controlled study comparing the cognitive effects of transcranial laser stimulation on category learning tasks. Transcranial infrared laser stimulation is a new non-invasive form of brain stimulation that shows promise for wide-ranging experimental and neuropsychological applications. It involves using infrared laser to enhance cerebral oxygenation and energy metabolism through upregulation of the respiratory enzyme cytochrome oxidase, the primary infrared photon acceptor in cells...
December 27, 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28001759/transcranial-low-level-laser-light-therapy-for-brain-injury
#8
Connor Thunshelle, Michael R Hamblin
BACKGROUND: Low-level laser therapy (LLLT) or photobiomodulation (PBM) is a possible treatment for brain injury, including traumatic brain injury (TBI). METHODS: We review the fundamental mechanisms at the cellular and molecular level and the effects on the brain are discussed. There are several contributing processes that have been proposed to lead to the beneficial effects of PBM in treating TBI such as stimulation of neurogenesis, a decrease in inflammation, and neuroprotection...
December 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27939089/the-resolve-trial-for-people-with-chronic-low-back-pain-protocol-for-a-randomised-clinical-trial
#9
Matthew K Bagg, Markus Hübscher, Martin Rabey, Benedict M Wand, Edel O'Hagan, G Lorimer Moseley, Tasha R Stanton, Chris G Maher, Stephen Goodall, Sopany Saing, Neil E O'Connell, Hannu Luomajoki, James H McAuley
INTRODUCTION: Low back pain is the leading worldwide cause of disability, and results in significant personal hardship. Most available treatments, when tested in high-quality randomised, controlled trials, achieve only modest improvements in pain, at best. Recently, treatments that target central nervous system function have been developed and tested in small studies. Combining treatments that target central nervous system function with traditional treatments directed towards functioning of the back is a promising approach that has yet to be tested in adequately powered, prospectively registered, clinical trials...
January 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/27815990/low-level-laser-therapy-for-beta-amyloid-toxicity-in-rat-hippocampus
#10
Yujiao Lu, Ruimin Wang, Yan Dong, Donovan Tucker, Ningjun Zhao, Md Ejaz Ahmed, Ling Zhu, Timon Cheng-Yi Liu, Robert M Cohen, Quanguang Zhang
Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male rats, and 2-minute daily LLI treatment was applied transcranially after Aβ injection for 5 consecutive days. LLI treatment suppressed Aβ-induced hippocampal neurodegeneration and long-term spatial and recognition memory impairments...
January 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/27752476/shining-light-on-the-head-photobiomodulation-for-brain-disorders
#11
REVIEW
Michael R Hamblin
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by humankind in general, is the brain. The brain suffers from many different disorders that can be classified into three broad groupings: traumatic events (stroke, traumatic brain injury, and global ischemia), degenerative diseases (dementia, Alzheimer's and Parkinson's), and psychiatric disorders (depression, anxiety, post traumatic stress disorder)...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27635607/-possibilities-of-non-drug-treatment-for-parkinson-s-disease
#12
REVIEW
D V Pokhabov, V G Abramov, D D Pokhabov
In this article, non-drug methods of treatment of Parkinson's disease are reviewed. Particular attention is given to the motor symptoms of disease, specifically to gait disorders. Information about objective methods of gait impairment is presented. Own results that confirm the effect of a method of tempo-rhythmical correction of walk in patients with Parkinson's disease (PD) and vascular parkinsonism as well as a device for assessment of gait parameters developed by the authors are analyzed. The efficacy of other methods of gait correction using external cues, study design and level of evidence are analyzed as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27456561/-patterns-of-ocular-neurovascular-reactions
#13
V I Lazarenko, A S Kadantseva, Yu I Savchenkov, R I Shatilova
AIM: To examine factors and determinants of ocular neurovascular reactions (NVR). MATERIAL AND METHODS: The study included 120 healthy participants of both sexes aged 20.9±0.6 years, who underwent a standard ophthalmic examination. Ocular microcirculation was recorded using laser Doppler flowmetry. Autonomic homeostasis and the intensity of slow-wave oscillations of hemodynamics were of interest. Autoregulation of cerebral blood flow was assessed by transcranial color-coded duplex scanning...
May 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27437987/transcranial-low-level-infrared-laser-irradiation-ameliorates-depression-induced-by-reserpine-in-rats
#14
Haitham S Mohammed
Transcranial low-level infrared laser is a modality of therapy based on the principle of photons delivered in a non-invasive manner through the skull for the treatment of some neurological conditions such as psychological disorders, traumatic brain injuries, and neurodegenerative diseases among others. In the present study, effects of low-level infrared laser irradiation with different radiation powers (80, 200, and 400 mW, continuous wave) were investigated on normal animals subjected to forced swimming test (FST)...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27379735/low-level-laser-irradiation-improves-depression-like-behaviors-in-mice
#15
Zhiqiang Xu, Xiaobo Guo, Yong Yang, Donovan Tucker, Yujiao Lu, Ning Xin, Gaocai Zhang, Lingli Yang, Jizhen Li, Xiangdong Du, Quanguang Zhang, Xingshun Xu
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated in a variety of neurodegenerative disorders associated with mitochondrial dysfunction and functional impairments. The goal of this study was to examine the effect of LLLT on depression-like behaviors and to explore the potential mechanism by detecting mitochondrial function following LLLT...
July 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27367569/therapeutic-effects-of-10-hzpulsed-wave-lasers-in-rat-depression-model-a-comparison-between-near-infrared-and-red-wavelengths
#16
Farzad Salehpour, Seyed Hossein Rasta, Gisou Mohaddes, Saeed Sadigh-Eteghad, Sima Salarirad
BACKGROUND AND OBJECTIVE: The application of transcranial low-level light/laser therapy (tLLLT) in the range of red to near-infrared (NIR) spectrum for psychological disorders is a new area that is attracting growing interest in recent years. The photomodulation effects of NIR and red coherent lights on the activity of cytochrome c oxidase in neuronal cells of brain have been recently introduced. This study, therefore, sought to compare the therapeutic effects of 10-Hz pulsed wave NIR (810 nm) laser with red (630 nm) laser using the same delivered energy density and Citalopram in rat chronic mild stress (CMS) model of depression and anxiety...
September 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27345389/dose-finding-study-of-phototherapy-on-stroke-outcome-in-a-rabbit-model-of-ischemic-stroke
#17
Dawn M Meyer, YongMei Chen, Justin A Zivin
GOAL: While transcranial laser therapy (TLT) has been shown to improve clinical outcome in a preclinical model of ischemic stroke, optimal timing and dosing has yet to be tested adequately. The purpose of this study was to assess clinical stroke outcome in the Rabbit Small Clot Embolic Model (RSCEM) with dose escalating TLT. METHODS: We utilized the rabbit small clot embolic stroke model (RSCEM) using dose-escalating regimens. Behavioral analysis was conducted at 24h post-embolization, allowing for the determination of the effective stroke dose (ES50) or clot amount (mg) that produces neurological deficits in 50% of a group of rabbits...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27267860/transcranial-laser-stimulation-as-neuroenhancement-for-attention-bias-modification-in-adults-with-elevated-depression-symptoms
#18
Seth G Disner, Christopher G Beevers, Francisco Gonzalez-Lima
BACKGROUND: Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy has been inconclusive. Adjunctive neuroenhancement to augment clinical effectiveness has shown promise, particularly for individuals who respond positively to the primary intervention...
September 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27220529/cognitive-enhancement-by-transcranial-laser-stimulation-and-acute-aerobic-exercise
#19
RANDOMIZED CONTROLLED TRIAL
Jungyun Hwang, Darla M Castelli, F Gonzalez-Lima
This is the first randomized, controlled study comparing the cognitive effects of transcranial laser stimulation and acute aerobic exercise on the same cognitive tasks. We examined whether transcranial infrared laser stimulation of the prefrontal cortex, acute high-intensity aerobic exercise, or the combination may enhance performance in sustained attention and working memory tasks. Sixty healthy young adults were randomly assigned to one of the following four treatments: (1) low-level laser therapy (LLLT) with infrared laser to two forehead sites while seated (total 8 min, 1064 nm continuous wave, 250 mW/cm(2), 60 J/cm(2) per site of 13...
August 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27208831/effects-of-left-primary-motor-and-dorsolateral-prefrontal-cortex-transcranial-direct-current-stimulation-on-laser-evoked-potentials-in-migraine-patients-and-normal-subjects
#20
Eleonora Vecchio, Katia Ricci, Anna Montemurno, Marianna Delussi, Sara Invitto, Marina de Tommaso
Migraine is characterized by an altered cortical excitability. Because transcranial direct current stimulation (tDCS) can change brain activity noninvasively, it is possible to hypothesize its efficacy in modulating pain in migraine. In this study, we compared the effects of tDCS of the left primary motor cortex (M1) and left dorsolateral prefrontal cortex (DLPFC) both on subjective pain and on evoked responses induced by laser stimulation (LEPs). Thirty-two patients and sixteen controls were randomized to receive sham stimulation and real tDCS with the anode centered over M1 or DLPFC...
July 28, 2016: Neuroscience Letters
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