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https://www.readbyqxmd.com/read/27815990/low-level-laser-therapy-for-beta-amyloid-toxicity-in-rat-hippocampus
#1
Yujiao Lu, Ruimin Wang, Yan Dong, Donovan Tucker, Ningjun Zhao, Md Ejaz Ahmed, Ling Zhu, Timon Cheng-Yi Liu, Robert M Cohen, Quanguang Zhang
Beta amyloid (Aβ) is well accepted to play a central role in the pathogenesis of Alzheimer's disease (AD). The present work evaluated the therapeutic effects of low-level laser irradiation (LLI) on Aβ-induced neurotoxicity in rat hippocampus. Aβ 1-42 was injected bilaterally to the hippocampus CA1 region of adult male rats, and 2-minute daily LLI treatment was applied transcranially after Aβ injection for 5 consecutive days. LLI treatment suppressed Aβ-induced hippocampal neurodegeneration and long-term spatial and recognition memory impairments...
October 11, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27752476/shining-light-on-the-head-photobiomodulation-for-brain-disorders
#2
Michael R Hamblin
Photobiomodulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect tissue that has either been injured, is degenerating, or else is at risk of dying. One of the organ systems of the human body that is most necessary to life, and whose optimum functioning is most worried about by humankind in general, is the brain. The brain suffers from many different disorders that can be classified into three broad groupings: traumatic events (stroke, traumatic brain injury, and global ischemia), degenerative diseases (dementia, Alzheimer's and Parkinson's), and psychiatric disorders (depression, anxiety, post traumatic stress disorder)...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27635607/-possibilities-of-non-drug-treatment-for-parkinson-s-disease
#3
D V Pokhabov, V G Abramov, D D Pokhabov
In this article, non-drug methods of treatment of Parkinson's disease are reviewed. Particular attention is given to the motor symptoms of disease, specifically to gait disorders. Information about objective methods of gait impairment is presented. Own results that confirm the effect of a method of tempo-rhythmical correction of walk in patients with Parkinson's disease (PD) and vascular parkinsonism as well as a device for assessment of gait parameters developed by the authors are analyzed. The efficacy of other methods of gait correction using external cues, study design and level of evidence are analyzed as well...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27456561/-patterns-of-ocular-neurovascular-reactions
#4
V I Lazarenko, A S Kadantseva, Yu I Savchenkov, R I Shatilova
AIM: To examine factors and determinants of ocular neurovascular reactions (NVR). MATERIAL AND METHODS: The study included 120 healthy participants of both sexes aged 20.9±0.6 years, who underwent a standard ophthalmic examination. Ocular microcirculation was recorded using laser Doppler flowmetry. Autonomic homeostasis and the intensity of slow-wave oscillations of hemodynamics were of interest. Autoregulation of cerebral blood flow was assessed by transcranial color-coded duplex scanning...
May 2016: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/27437987/transcranial-low-level-infrared-laser-irradiation-ameliorates-depression-induced-by-reserpine-in-rats
#5
Haitham S Mohammed
Transcranial low-level infrared laser is a modality of therapy based on the principle of photons delivered in a non-invasive manner through the skull for the treatment of some neurological conditions such as psychological disorders, traumatic brain injuries, and neurodegenerative diseases among others. In the present study, effects of low-level infrared laser irradiation with different radiation powers (80, 200, and 400 mW, continuous wave) were investigated on normal animals subjected to forced swimming test (FST)...
November 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27379735/low-level-laser-irradiation-improves-depression-like-behaviors-in-mice
#6
Zhiqiang Xu, Xiaobo Guo, Yong Yang, Donovan Tucker, Yujiao Lu, Ning Xin, Gaocai Zhang, Lingli Yang, Jizhen Li, Xiangdong Du, Quanguang Zhang, Xingshun Xu
Major depressive disorder (MDD) is one of the leading forms of psychiatric disorders, characterized by aversion to mobility, neurotransmitter deficiency, and energy metabolic decline. Low-level laser therapy (LLLT) has been investigated in a variety of neurodegenerative disorders associated with mitochondrial dysfunction and functional impairments. The goal of this study was to examine the effect of LLLT on depression-like behaviors and to explore the potential mechanism by detecting mitochondrial function following LLLT...
July 5, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27367569/therapeutic-effects-of-10-hzpulsed-wave-lasers-in-rat-depression-model-a-comparison-between-near-infrared-and-red-wavelengths
#7
Farzad Salehpour, Seyed Hossein Rasta, Gisou Mohaddes, Saeed Sadigh-Eteghad, Sima Salarirad
BACKGROUND AND OBJECTIVE: The application of transcranial low-level light/laser therapy (tLLLT) in the range of red to near-infrared (NIR) spectrum for psychological disorders is a new area that is attracting growing interest in recent years. The photomodulation effects of NIR and red coherent lights on the activity of cytochrome c oxidase in neuronal cells of brain have been recently introduced. This study, therefore, sought to compare the therapeutic effects of 10-Hz pulsed wave NIR (810 nm) laser with red (630 nm) laser using the same delivered energy density and Citalopram in rat chronic mild stress (CMS) model of depression and anxiety...
September 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27345389/dose-finding-study-of-phototherapy-on-stroke-outcome-in-a-rabbit-model-of-ischemic-stroke
#8
Dawn M Meyer, YongMei Chen, Justin A Zivin
GOAL: While transcranial laser therapy (TLT) has been shown to improve clinical outcome in a preclinical model of ischemic stroke, optimal timing and dosing has yet to be tested adequately. The purpose of this study was to assess clinical stroke outcome in the Rabbit Small Clot Embolic Model (RSCEM) with dose escalating TLT. METHODS: We utilized the rabbit small clot embolic stroke model (RSCEM) using dose-escalating regimens. Behavioral analysis was conducted at 24h post-embolization, allowing for the determination of the effective stroke dose (ES50) or clot amount (mg) that produces neurological deficits in 50% of a group of rabbits...
September 6, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27267860/transcranial-laser-stimulation-as-neuroenhancement-for-attention-bias-modification-in-adults-with-elevated-depression-symptoms
#9
Seth G Disner, Christopher G Beevers, Francisco Gonzalez-Lima
BACKGROUND: Low-level light therapy (LLLT) with transcranial laser is a non-invasive form of neuroenhancement shown to regulate neuronal metabolism and cognition. Attention bias modification (ABM) is a cognitive intervention designed to improve depression by decreasing negative attentional bias, but to date its efficacy has been inconclusive. Adjunctive neuroenhancement to augment clinical effectiveness has shown promise, particularly for individuals who respond positively to the primary intervention...
September 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27220529/cognitive-enhancement-by-transcranial-laser-stimulation-and-acute-aerobic-exercise
#10
Jungyun Hwang, Darla M Castelli, F Gonzalez-Lima
This is the first randomized, controlled study comparing the cognitive effects of transcranial laser stimulation and acute aerobic exercise on the same cognitive tasks. We examined whether transcranial infrared laser stimulation of the prefrontal cortex, acute high-intensity aerobic exercise, or the combination may enhance performance in sustained attention and working memory tasks. Sixty healthy young adults were randomly assigned to one of the following four treatments: (1) low-level laser therapy (LLLT) with infrared laser to two forehead sites while seated (total 8 min, 1064 nm continuous wave, 250 mW/cm(2), 60 J/cm(2) per site of 13...
August 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27208831/effects-of-left-primary-motor-and-dorsolateral-prefrontal-cortex-transcranial-direct-current-stimulation-on-laser-evoked-potentials-in-migraine-patients-and-normal-subjects
#11
Eleonora Vecchio, Katia Ricci, Anna Montemurno, Marianna Delussi, Sara Invitto, Marina de Tommaso
Migraine is characterized by an altered cortical excitability. Because transcranial direct current stimulation (tDCS) can change brain activity noninvasively, it is possible to hypothesize its efficacy in modulating pain in migraine. In this study, we compared the effects of tDCS of the left primary motor cortex (M1) and left dorsolateral prefrontal cortex (DLPFC) both on subjective pain and on evoked responses induced by laser stimulation (LEPs). Thirty-two patients and sixteen controls were randomized to receive sham stimulation and real tDCS with the anode centered over M1 or DLPFC...
July 28, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27180104/a-novel-method-to-promote-behavioral-improvement-and-enhance-mitochondrial-function-following-an-embolic-stroke
#12
Paul A Lapchak, Paul D Boitano
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for stroke; tPA increases cerebral reperfusion, blood flow and improved behavior. Novel transcranial laser therapy (TLT) also enhances cerebral blood flow and activates mitochondrial function. Using the rabbit small clot embolic stroke model (RSCEM), we studied the effects of continuous wave TLT (7.5mW/cm(2)) alone or in combination with standardized intravenous (IV) tPA (3.3mg/kg) applied 1h post-embolization on 3 endpoints: 1) behavioral function measured 2 days [effective stroke dose (P50 in mg) producing neurological deficits in 50% of embolized rabbits], 2) intracerebral hemorrhage (ICH) rate, and 3) cortical adenosine-5'-triphosphate (ATP) content was measured 6h following embolization...
September 1, 2016: Brain Research
https://www.readbyqxmd.com/read/27115021/errata-transcranial-low-level-laser-therapy-810-nm-temporarily-inhibits-peripheral-nociception-photoneuromodulation-of-glutamate-receptors-prostatic-acid-phophatase-and-adenosine-triphosphate
#13
Marcelo Victor Pires de Sousa, Cleber Ferraresi, Masayoshi Kawakubo, Beatriz Kaippert, Elisabeth Mateus Yoshimura, Michael R Hamblin
[This corrects the article DOI: 10.1117/1.NPh.3.1.015003.].
January 2016: Neurophotonics
https://www.readbyqxmd.com/read/27107026/optogenetic-induction-of-cortical-spreading-depression-in-anesthetized-and-freely-behaving-mice
#14
Thijs Houben, Inge Cm Loonen, Serapio M Baca, Maarten Schenke, Johanna H Meijer, Michel D Ferrari, Gisela M Terwindt, Rob A Voskuyl, Andrew Charles, Arn Mjm van den Maagdenberg, Else A Tolner
Cortical spreading depression, which plays an important role in multiple neurological disorders, has been studied primarily with experimental models that use highly invasive methods. We developed a relatively non-invasive optogenetic model to induce cortical spreading depression by transcranial stimulation of channelrhodopsin-2 ion channels expressed in cortical layer 5 neurons. Light-evoked cortical spreading depression in anesthetized and freely behaving mice was studied with intracortical DC-potentials, multi-unit activity and/or non-invasive laser Doppler flowmetry, and optical intrinsic signal imaging...
April 22, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27080072/non-invasive-brain-stimulation-to-promote-alertness-and-awareness-in-chronic-patients-with-disorders-of-consciousness-low-level-near-infrared-laser-stimulation-vs-focused-shock-wave-therapy
#15
Cordula Werner, Manuela Byhahn, Stefan Hesse
PURPOSE: In order to promote alertness and awareness in patients with severe disorders of consciousness (DOC) frontal near infrared laser stimulation (N-LT) or transcranial focused shock wave therapy (F-SWT) might be an option. The study compared both techniques in severe chronic DOC patients. METHODS: Sixteen DOC patients were allocated to two groups (A and B). A three week baseline either followed a frontal N-LT (0,1 mJ/mm2, 10 min per session), five times a week over four weeks (group A), or a F-SWT (0,1 mJ/mm2, 4000 stimuli per session) three times a week over four weeks (group B)...
April 11, 2016: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/26990361/repeated-transcranial-low-level-laser-therapy-for-traumatic-brain-injury-in-mice-biphasic-dose-response-and-long-term-treatment-outcome
#16
Weijun Xuan, Liyi Huang, Michael R Hamblin
We previously showed that near-infrared laser photobiomodulation (PBM) (810 nm, CW, 18 J/cm(2) , 25 mW/cm(2) ) delivered to the mouse daily for 3-days after a controlled cortical impact traumatic brain injury (TBI) gave a significant improvement in neurological/cognitive function. However the same parameters delivered 14X daily gave significantly less benefit. This biphasic dose response intrigued us, and we decided to follow the mice that received 3X or 14X laser treatments out to 56-days post-TBI. We found the 14X group showed worse neurological function than the no-treatment TBI group at 2-weeks, but started to improve steadily during the next 6-weeks, and by 56-days were significantly better than the no-treatment TBI mice, but still worse than the 3X mice...
March 15, 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/26989758/review-of-transcranial-photobiomodulation-for-major-depressive-disorder-targeting-brain-metabolism-inflammation-oxidative-stress-and-neurogenesis
#17
REVIEW
Paolo Cassano, Samuel R Petrie, Michael R Hamblin, Theodore A Henderson, Dan V Iosifescu
We examined the use of near-infrared and red radiation (photobiomodulation, PBM) for treating major depressive disorder (MDD). While still experimental, preliminary data on the use of PBM for brain disorders are promising. PBM is low-cost with potential for wide dissemination; further research on PBM is sorely needed. We found clinical and preclinical studies via PubMed search (2015), using the following keywords: "near-infrared radiation," "NIR," "low-level light therapy," "low-level laser therapy," or "LLLT" plus "depression...
July 2016: Neurophotonics
https://www.readbyqxmd.com/read/26878583/broadband-acoustic-properties-of-a-murine-skull
#18
Héctor Estrada, Johannes Rebling, Jake Turner, Daniel Razansky
It has been well recognized that the presence of a skull imposes harsh restrictions on the use of ultrasound and optoacoustic techniques in the study, treatment and modulation of the brain function. We propose a rigorous modeling and experimental methodology for estimating the insertion loss and the elastic constants of the skull over a wide range of frequencies and incidence angles. A point-source-like excitation of ultrawideband acoustic radiation was induced via the absorption of nanosecond duration laser pulses by a 20 μm diameter microsphere...
March 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/26846218/high-hypnotizability-impairs-the-cerebellar-control-of-pain
#19
Tommaso Bocci, Davide Barloscio, Laura Parenti, Ferdinando Sartucci, Giancarlo Carli, Enrica L Santarcangelo
In the general population, transcranial anodal direct current stimulation of the cerebellum (ctDCS) reduces pain intensity and the amplitude of nociceptive laser evoked potentials (LEPs), whereas cathodal ctDCS elicits opposite effects. Since behavioral findings suggest that the cerebellar activity of highly hypnotizable individuals (highs) differs from the general population, we investigated whether hypnotizability-related differences occur in the modulation of pain by ctDCS. Sixteen healthy highs (according to the Stanford Hypnotic Susceptibility Scale, form A) and 16 participants not selected according to hypnotizability (controls) volunteered to undergo laser nociceptive stimulation of the dorsum of the left hand before and after anodal or cathodal ctDCS...
February 5, 2016: Cerebellum
https://www.readbyqxmd.com/read/26835486/transcranial-low-level-laser-therapy-810%C3%A2-nm-temporarily-inhibits-peripheral-nociception-photoneuromodulation-of-glutamate-receptors-prostatic-acid-phophatase-and-adenosine-triphosphate
#20
Marcelo Victor Pires de Sousa, Cleber Ferraresi, Masayoshi Kawakubo, Beatriz Kaippert, Elisabeth Mateus Yoshimura, Michael R Hamblin
Photobiomodulation or low-level light therapy has been shown to attenuate both acute and chronic pain, but the mechanism of action is not well understood. In most cases, the light is applied to the painful area, but in the present study we applied light to the head. We found that transcranial laser therapy (TLT) applied to mouse head with specific parameters (810 nm laser, [Formula: see text], 7.2 or [Formula: see text]) decreased the reaction to pain in the foot evoked either by pressure (von Frey filaments), cold, or inflammation (formalin injection) or in the tail (evoked by heat)...
January 2016: Neurophotonics
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