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Transcranial alternating current stimulation

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https://www.readbyqxmd.com/read/29207262/transcranial-electrical-stimulation
#1
Sven Bestmann, Vincent Walsh
Transcranial electrical stimulation (tES) is a neuromodulatory technique in which low voltage constant or alternating currents are applied to the human brain via scalp electrodes. The basic idea of tES is that the application of weak currents can interact with neural processing, modify plasticity and entrain brain networks, and that this in turn can modify behaviour. The technique is now widely employed in basic and translational research, and increasingly is also used privately in sport, the military and recreation...
December 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29200551/efficacy-of-transcranial-direct-current-stimulation-in-the-treatment-resistant-patients-who-suffer-from-severe-obsessive-compulsive-disorder
#2
Kiomars Najafi, Youssef Fakour, Homa Zarrabi, Abtin Heidarzadeh, Mohammadrasoul Khalkhali, Taiebeh Yeganeh, Hasan Farahi, Marziyeh Rostamkhani, Tahereh Najafi, Soheil Shabafroz, Mahdiyeh Pakdaman
Background: During the past years, significant efforts have been made to explain the biological backgrounds of obsessive-compulsive disorder (OCD). Cortical-subcortical and neurotransmitter models are used for explaining the symptoms of OCD, so our hypothesis is that brain's transcranial direct current stimulation (TDCS) can regulate the brain activities of the OCD patients. Thus, based on the mentioned issues, this research seeks to investigate the efficacy of TDCS in treatment-resistant patients who suffer from severe OCD...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29196322/a-new-high-efficacy-non-invasive-transcranial-electric-stimulation-tuned-to-local-neurodynamics
#3
Carlo Cottone, Andrea Cancelli, Patrizio Pasqualetti, Camillo Porcaro, Carlo Salustri, Franca Tecchio
In this paper, we pose the following working hypothesis: in humans, transcranial electric stimulation (tES) with a time course that mimics the endogenous activity of its target is capable of altering the target's excitability. In our case, the target was the primary motor cortex (M1). We identified the endogenous neurodynamics of hand M1's subgroups of pyramidal neuronal pools in each of our subjects by applying Functional Source Separation (FSS) to their electroencephalographic (EEG) recordings. We then tested whether the cortico-spinal excitability of the hand representation under the above described stimulation, which we named transcranial Individual neuroDynamics Stimulation (tIDS), was higher than in the absence of stimulation (baseline)...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29187553/ih-interacts-with-somato-dendritic-structure-to-determine-frequency-response-to-weak-alternating-electric-field-stimulation
#4
Enrique H S Toloza, Ehsan Negahbani, Flavio Frohlich
Transcranial current stimulation (tCS) modulates brain dynamics using weak electric fields. Given the pathological changes in brain network oscillations in neurological and psychiatric illnesses, using alternating electric field waveforms that engage rhythmic activity has been proposed as a targeted, network-level treatment approach. Previous studies have investigated the effects of electric fields at the neuronal level. However, the biophysical basis of the cellular response to electric fields has remained limited...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29180075/cortical-neuromodulation-for-neuropathic-pain-and-parkinson-disease-where-are-we
#5
Angelo Lavano, Giusy Guzzi, Domenico Chirchiglia
Cortex neuromodulation is promising approach for treatment of some neurological conditions, especially neuropathic pain and Parkinson's disease. Effects of non-invasive cortical stimulation are short lived; transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) may be useful to assess the suitability for invasive cortical stimulation. Direct cortical stimulation (DCS) is the method able to provide long-lasting effects in treatment of neuropathic pain and some symptoms of Parkinson's disease through the use of totally implantable systems that ensure a chronic stimulation...
November 13, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29176918/the-influence-of-transcranial-alternating-current-stimulation-tacs-on-fluid-intelligence-an-fmri-study
#6
A C Neubauer, M Wammerl, M Benedek, E Jauk, N Jaušovec
The past decades have witnessed a huge interest in uncovering the neural bases of intelligence (e.g., Stelmack, & Houlihan, 1995; Stelmack, Knott, & Beauchamp, 2003). This study investigated the influence of transcranial alternating current stimulation (tACS) on fluid intelligence performance and corresponding brain activation. Previous findings showed that left parietal theta tACS leads to a transient increase in fluid reasoning performance. In an attempt to extend and replicate these findings, we combined theta tACS with fMRI...
November 1, 2017: Personality and Individual Differences
https://www.readbyqxmd.com/read/29171414/non-invasive-electrical-brain-stimulation-from-acute-to-late-stage-treatment-of-central-nervous-system-damage
#7
REVIEW
Petra Henrich-Noack, Elena G Sergeeva, Bernhard A Sabel
Non-invasive brain current stimulation (NIBS) is a promising and versatile tool for inducing neuroplasticity, protection and functional rehabilitation of damaged neuronal systems. It is technically simple, requires no surgery, and has significant beneficial effects. However, there are various technical approaches for NIBS which influence neuronal networks in significantly different ways. Transcranial direct current stimulation (tDCS), alternating current stimulation (ACS) and repetitive transcranial magnetic stimulation (rTMS) all have been applied to modulate brain activity in animal experiments under normal and pathological conditions...
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29167638/hyper-transcranial-alternating-current-stimulation-experimental-manipulation-of-inter-brain-synchrony
#8
Caroline Szymanski, Viktor Müller, Timothy R Brick, Timo von Oertzen, Ulman Lindenberger
We walk together, we watch together, we win together: Interpersonally coordinated actions are omnipresent in everyday life, yet the associated neural mechanisms are not well understood. Available evidence suggests that the synchronization of oscillatory activity across brains may provide a mechanism for the temporal alignment of actions between two or more individuals. In an attempt to provide a direct test of this hypothesis, we applied transcranial alternating current stimulation simultaneously to two individuals (hyper-tACS) who were asked to drum in synchrony at a set pace...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29165241/lifting-the-veil-on-the-dynamics-of-neuronal-activities-evoked-by-transcranial-magnetic-stimulation
#9
Bingshuo Li, Juha P Virtanen, Axel Oeltermann, Cornelius Schwarz, Martin A Giese, Ulf Ziemann, Alia Benali
Transcranial magnetic stimulation (TMS) is a widely used non-invasive tool to study and modulate human brain functions. However, TMS-evoked activity of individual neurons has remained largely inaccessible due to the large TMS-induced electromagnetic fields. Here we present a general method providing direct in vivo electrophysiological access to TMS-evoked neuronal activity 0.8-1 ms after TMS onset. We translated human single-pulse TMS to rodents and unveiled time-grained evoked activities of motor cortex layer V neurons that show high-frequency spiking within the first 6 ms depending on TMS-induced current orientation and a multiphasic spike-rhythm alternating between excitation and inhibition in the 6-300 ms epoch, all of which can be linked to various human TMS responses recorded at the level of spinal cord and muscles...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29163104/transcranial-random-noise-stimulation-does-not-improve-behavioral-and-neurophysiological-measures-in-patients-with-subacute-vegetative-unresponsive-wakefulness-state-vs-uws
#10
Mauro Mancuso, Laura Abbruzzese, Stefania Canova, Giulia Landi, Simone Rossi, Emiliano Santarnecchi
Background: The absence of efficient treatments capable to promote central nervous system recovery in patients in vegetative state (VS) due to a severe acquired brain injury highlights the need of exploring alternative neuromodulatory treatments that can lead to neurobehavioral gains. Some encouraging preliminary observations suggest that transcranial direct current stimulation could be effective in disorders of consciousness (DoC) patients, especially when applied on the dorsolateral prefrontal cortex (DLPFC) in patients with minimally conscious state (MCS) but not in those with VS...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29160331/primum-non-nocere-or-primum-facere-meliorem-hacking-the-brain-in-the-21st-century
#11
Lucas Borrione, Andre R Brunoni
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that modulates cortical excitability. It is devoid of serious adverse events and exerts variable effects on cognition, with several research findings suggesting that it can improve memory, verbal and mathematical skills. Because tDCS devices are low-cost, portable and relatively easy to assemble, they have become available outside of the medical setting and used for non-medical ("cosmetic") purposes by laypersons. In this sense, tDCS has become a popular technique aiming to improve cognition and the achievement of a better performance not only at work, but also in other fields such as sports, leisure activities (video games) and even the military...
November 13, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/29155756/transcranial-electrical-brain-stimulation-in-alert-rodents
#12
Brita Fritsch, Anne-Kathrin Gellner, Janine Reis
Transcranial electrical brain stimulation can modulate cortical excitability and plasticity in humans and rodents. The most common form of stimulation in humans is transcranial direct current stimulation (tDCS). Less frequently, transcranial alternating current stimulation (tACS) or transcranial random noise stimulation (tRNS), a specific form of tACS using an electrical current applied randomly within a pre-defined frequency range, is used. The increase of noninvasive electrical brain stimulation research in humans, both for experimental and clinical purposes, has yielded an increased need for basic, mechanistic, safety studies in animals...
November 2, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29142322/bilateral-5%C3%A2-hz-transcranial-alternating-current-stimulation-on-fronto-temporal-areas-modulates-resting-state-eeg
#13
Aurora D'Atri, Claudia Romano, Maurizio Gorgoni, Serena Scarpelli, Valentina Alfonsi, Michele Ferrara, Fabio Ferlazzo, Paolo Maria Rossini, Luigi De Gennaro
Rhythmic non-invasive brain stimulations are promising tools to modulate brain activity by entraining neural oscillations in specific cortical networks. The aim of the study was to assess the possibility to influence the neural circuits of the wake-sleep transition in awake subjects via a bilateral transcranial alternating current stimulation at 5 Hz (θ-tACS) on fronto-temporal areas. 25 healthy volunteers participated in two within-subject sessions (θ-tACS and sham), one week apart and in counterbalanced order...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29122535/limited-output-transcranial-electrical-stimulation-lotes-2017-engineering-principles-regulatory-statutes-and-industry-standards-for-wellness-over-the-counter-or-prescription-devices-with-low-risk
#14
Marom Bikson, Bhaskar Paneri, Andoni Mourdoukoutas, Zeinab Esmaeilpour, Bashar W Badran, Robin Azzam, Devin Adair, Abhishek Datta, Xiao Hui Fang, Brett Wingeier, Daniel Chao, Miguel Alonso-Alonso, Kiwon Lee, Helena Knotkova, Adam J Woods, David Hagedorn, Doug Jeffery, James Giordano, William J Tyler
We present device standards for low-power non-invasive electrical brain stimulation devices classified as limited output transcranial electrical stimulation (tES). Emerging applications of limited output tES to modulate brain function span techniques to stimulate brain or nerve structures, including transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), and transcranial pulsed current stimulation (tPCS), have engendered discussion on how access to technology should be regulated...
October 17, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29100950/effects-of-alpha-and-gamma-transcranial-alternating-current-stimulation-tacs-on-verbal-creativity-and-intelligence-test-performance
#15
Roland H Grabner, Julia Krenn, Andreas Fink, Martin Arendasy, Mathias Benedek
Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that allows to directly modulate brain oscillations of a given frequency. Using this method, it was recently shown that increasing alpha (10Hz) oscillations improved creative ideation with figural material and that increasing gamma (40Hz) oscillations speeded up performance in a figural matrices intelligence task. The aim of the present study was to examine whether these findings generalize to verbal creativity and intelligence tasks...
October 31, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/29079460/optimized-auditory-transcranial-alternating-current-stimulation-improves-individual-auditory-temporal-resolution
#16
Alina Baltus, Sven Wagner, Carsten Hermann Wolters, Christoph Siegfried Herrmann
BACKGROUND: Temporal resolution of cortical, auditory processing mechanisms is suggested to be linked to peak frequency of neuronal gamma oscillations in auditory cortex areas (individual gamma frequency, IGF): Individuals with higher IGF tend to have better temporal resolution. HYPOTHESIS: Modulating ongoing gamma activity with transcranial alternating current stimulation (tACS) is expected to improve performance in gap detection (GD) tasks (shorter GD thresholds) if the frequency is higher and to decrease GD performance (longer GD thresholds) if the frequency is lower than IGF...
October 17, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/29073084/disruption-and-rescue-of-interareal-theta-phase-coupling-and-adaptive-behavior
#17
Robert M G Reinhart
Rescuing executive functions in people with neurological and neuropsychiatric disorders has been a major goal of psychology and neuroscience for decades. Innovative computer-training regimes for executive functions have made tremendous inroads, yet the positive effects of training have not always translated into improved cognitive functioning and often take many days to emerge. In the present study, we asked whether it was possible to immediately change components of executive function by directly manipulating neural activity using a stimulation technology called high-definition transcranial alternating current stimulation (HD-tACS)...
October 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29065603/safety-of-the-transcranial-focal-electrical-stimulation-via-tripolar-concentric-ring-electrodes-for-hippocampal-ca3-subregion-neurons-in-rats
#18
Samuel Mucio-Ramírez, Oleksandr Makeyev
Epilepsy is a neurological disorder that affects approximately one percent of the world population. Noninvasive electrical brain stimulation via tripolar concentric ring electrodes has been proposed as an alternative/complementary therapy for seizure control. Previous results suggest its efficacy attenuating acute seizures in penicillin, pilocarpine-induced status epilepticus, and pentylenetetrazole-induced rat seizure models and its safety for the rat scalp, cortical integrity, and memory formation. In this study, neuronal counting was used to assess possible tissue damage in rats (n = 36) due to the single dose or five doses (given every 24 hours) of stimulation on hippocampal CA3 subregion neurons 24 hours, one week, and one month after the last stimulation dose...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29021749/phase-dependent-modulation-of-signal-transmission-in-cortical-networks-through-tacs-induced-neural-oscillations
#19
Kristoffer D Fehér, Masahito Nakataki, Yosuke Morishima
Oscillatory neural activity is considered a basis of signal transmission in brain networks. However, the causal role of neural oscillations in regulating cortico-cortical signal transmission has so far not been directly demonstrated. To date, due to methodological limitations, studies on the online modulatory mechanisms of transcranial alternating current stimulation (tACS)-induced neural oscillations are confined to the primary motor cortex. To address the causal role of oscillatory activity in modulating cortico-cortical signal transmission, we have established a new method using concurrent tACS, transcranial magnetic stimulation (TMS) and electroencephalography (EEG)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29018896/hypericum-perforatum-extract-modulates-cortical-plasticity-in-humans
#20
Carmen Concerto, Hyunji Boo, Charles Hu, Priam Sandilya, Anita Krish, Eileen Chusid, Diego Coira, Eugenio Aguglia, Fortunato Battaglia
BACKGROUND: Hypericum perforatum (HYP) extract is one of the most commonly used complementary alternative medicines (CAMs) for the treatment of mild-to-moderate depression. Non-invasive brain stimulation protocols can be used to investigate the effect of psychoactive substances on the human brain. In this study, we explored the effect of a single dose of HYP extract (WS 5570) intake on corticospinal excitability and plasticity in humans. METHODS: Twenty-eight healthy subjects were required to intake 900 mg of either HYP extract or placebo...
October 10, 2017: Psychopharmacology
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