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https://www.readbyqxmd.com/read/29148096/performance-of-the-dimension-tac-assay-and-comparison-of-multiple-platforms-for-the-measurement-of-tacrolimus
#1
Eun-Jung Cho, Dae-Hyun Ko, Woochang Lee, Sail Chun, Hae-Kyung Lee, Won-Ki Min
BACKGROUND: Therapeutic monitoring of tacrolimus is essential for reducing organ rejection and adverse effects. The measurement of tacrolimus in whole blood is taken by many automated platforms. We evaluated the analytical performance of the Dimension TAC assay, which is an upgraded reagent from the previous Dimension TACR assay. METHODS: The evaluations involved determination of precision, linearity, detection capability, and reagent lot-to-lot variability between three lot numbers...
November 17, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29147650/mitochondria-associated-microrna-expression-profiling-of-heart-failure
#2
Xiaoxia Wang, Chun Song, Xiao Zhou, Xiaorui Han, Jun Li, Zengwu Wang, Haibao Shang, Yuli Liu, Huiqing Cao
Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism impairment. MicroRNAs are implicated in the development of heart failure. However, the mitochondria enriched microRNA during heart failure remains elusive. Here, we generated a pressure overload-induced early and late stage heart failure model at 4 weeks and 8 weeks following transverse aortic constriction (TAC) in mice. We found that expression of mitochondrion protein COX4 was highly enriched in isolated mitochondria from cardiac tissues while GAPDH could hardly be detected...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29147482/combined-postconditioning-with-ischemia-and-cyclosporine-a-restore-oxidative-stress-and-histopathological-changes-in-reperfusion-injury-of-diabetic-myocardium
#3
Reza Badalzadeh, Seyed Mahmoud Tabatabaei, Mustafa Mohammadi, Arash Khaki, Dariush Mohammadnezhad
Objectives: Chronic diabetes impedes cardioprotection in reperfusion injury and hence protecting the diabetic heart would have important outcomes. In this study, we evaluated whether combined postconditioning with ischemia and cyclosporine-A can restore oxidative stress and histopathological changes in reperfusion injury of the diabetic myocardium. Materials and Methods: Streptozocin-induced diabetic hearts and nondiabetic controls in eight subgroups (with or without receiving ischemic-postconditioning (IPostC), cyclosporine-A, an inhibitor of mitochondrial permeability transition, or both of them) suffered from 30 min regional ischemia followed by 45 min reperfusion on an isolated-heart Langendorff system...
October 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29146813/structural-basis-of-bacterial-transcription-activation
#4
Bin Liu, Chuan Hong, Rick K Huang, Zhiheng Yu, Thomas A Steitz
In bacteria, the activation of gene transcription at many promoters is simple and only involves a single activator. The cyclic adenosine 3',5'-monophosphate receptor protein (CAP), a classic activator, is able to activate transcription independently through two different mechanisms. Understanding the class I mechanism requires an intact transcription activation complex (TAC) structure at a high resolution. Here we report a high-resolution cryo-electron microscopy structure of an intact Escherichia coli class I TAC containing a CAP dimer, a σ(70)-RNA polymerase (RNAP) holoenzyme, a complete class I CAP-dependent promoter DNA, and a de novo synthesized RNA oligonucleotide...
November 17, 2017: Science
https://www.readbyqxmd.com/read/29145451/stromal-interaction-molecule-1-haploinsufficiency-causes-maladaptive-response-to-pressure-overload
#5
Takayoshi Ohba, Hiroyuki Watanabe, Manabu Murakami, Kenji Iino, Takeshi Adachi, Yoshihiro Baba, Tomohiro Kurosaki, Kyoichi Ono, Hiroshi Ito
Stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca2+ sensor, has been shown to control a Ca2+-dependent signal that promotes cardiac hypertrophy. However, whether STIM1 has adaptive role that helps to protect against cardiac overload stress remains unknown. We hypothesized that STIM1 deficiency causes a maladaptive response to pressure overload stress. We investigated STIM1 heterozygous KO (STIM1+/-) mice hearts, in which STIM1 protein levels decreased to 27% of wild-type (WT) with no compensatory increase in STIM2...
2017: PloS One
https://www.readbyqxmd.com/read/29143686/acute-phase-proteins-and-markers-of-oxidative-stress-to-assess-the-severity-of-the-pulmonary-hypertension-in-heartworm-infected-dogs
#6
Elena Carretón, José Joaquín Cerón, Silvia Martínez-Subiela, Asta Tvarijonaviciute, Alicia Caro-Vadillo, José Alberto Montoya-Alonso
BACKGROUND: Canine heartworm infection is characterized by pulmonary endarteritis and pulmonary hypertension (PH). The aim of the present study was to evaluate the relationship between PH with the concentrations of different positive (C-reactive protein [CRP] and haptoglobin [Hp]) and negative (albumin and paraoxonase-1 [PON-1]) acute phase proteins (APP), as well as the oxidative stress, by measuring glutathione peroxidase (GPx) and total antioxidant capacity (TAC) in 27 heartworm-infected dogs on Day 0 (diagnosis) and Day 120 (1 month after the last adulticide injection)...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143180/oxidative-stress-in-adult-growth-hormone-deficiency-different-plasma-antioxidant-patterns-in-comparison-with-metabolic-syndrome
#7
Antonio Mancini, Chantal Di Segni, Carmine Bruno, Giulio Olivieri, Francesco Guidi, Andrea Silvestrini, Elisabetta Meucci, Patrick Orlando, Sonia Silvestri, Luca Tiano, Alfredo Pontecorvi
BACKGROUND AND AIMS: Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern...
November 15, 2017: Endocrine
https://www.readbyqxmd.com/read/29142979/two-year-follow-up-study-of-membranous-nephropathy-treated-with-tacrolimus-and-corticosteroids-versus-cyclical-corticosteroids-and-cyclophosphamide
#8
Raja Ramachandran, Ashok Kumar Yadav, Vinod Kumar, Venkata Siva Tez Pinnamaneni, Ritambhra Nada, Ratan Ghosh, Vivek Kumar, Manish Rathi, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja, Vivekanand Jha
Introduction: Both cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report of patients randomized to receive TAC/GCs or cCTX/GCs at 2 years post randomization. Methods: Seventy patients enrolled in the clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen in Treatment of Idiopathic Membranous Nephropathy: Randomized Control Trial were followed quarterly between 12 and 24 months...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29142429/antioxidant-and-hepatoprotective-potential-of-swaras-and-hima-extracts-of-tinospora-cordifolia-and-boerhavia-diffusa-in-swiss-albino-mice
#9
Amit Kaushik, Athar Husain, Harshika Awasthi, Dewasya Pratap Singh, Raziuddin Khan, Dayanandan Mani
Background: In Ayurveda, five basic extraction procedures are mentioned in order of their decreasing potency. Swaras is considered as the most potent followed by, kalka, kwatha, fanta and hima. Objective: Present study was carried out to investigate the antioxidant and hepatoprotective potential of swaras and hima extracts of T.cordifolia and B. diffusa. Materials and Methods: Swaras and hima extracts of T. cordifolia and B. diffusa were prepared...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142421/extract-of-bauhinia-vahlii-shows-antihyperglycemic-activity-reverses-oxidative-stress-and-protects-against-liver-damage-in-streptozotocin-induced-diabetic-rats
#10
Ahmed H Elbanna, Mohammed M Nooh, Engy A Mahrous, Amal E Khaleel, Taha S Elalfy
Background: Several studies have affirmed the effectiveness of some Bauhinia plants as antihyperglycemic agents. Objective: We investigated the possible effect of Bauhinia vahlii leaves extract in reducing hyperglycemia and reversing signs of organ damage associated with diabetes in streptozotocin (STZ) rat model. Materials and Methods: Both polar fraction of the B. vahlii leaves (defatted ethanolic extract [DEE]) and nonpolar fraction (n-hexane extract) were evaluated in vitro for α-glucosidase inhibition and 2,2-diphenyl-1-picrylhydrazyl radical scavenging potential...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142322/bilateral-5%C3%A2-hz-transcranial-alternating-current-stimulation-on-fronto-temporal-areas-modulates-resting-state-eeg
#11
Aurora D'Atri, Claudia Romano, Maurizio Gorgoni, Serena Scarpelli, Valentina Alfonsi, Michele Ferrara, Fabio Ferlazzo, Paolo Maria Rossini, Luigi De Gennaro
Rhythmic non-invasive brain stimulations are promising tools to modulate brain activity by entraining neural oscillations in specific cortical networks. The aim of the study was to assess the possibility to influence the neural circuits of the wake-sleep transition in awake subjects via a bilateral transcranial alternating current stimulation at 5 Hz (θ-tACS) on fronto-temporal areas. 25 healthy volunteers participated in two within-subject sessions (θ-tACS and sham), one week apart and in counterbalanced order...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141920/parathyroid-hormone-related-protein-modulates-mice-mesangial-cells-inflammation-and-blunts-apoptosis-by-enhancing-cox-2-expression
#12
Mazène Hochane, Denis Raison, Catherine Coquard, Claire Béraud, Audrey Bethry, Sabrina Danilin, Thierry Massfelder, Mariette Barthelmebs
Mesangial cell (MC) injury is a prominent feature of glomerulonephritis. Activated MC secretes inflammatory mediators which induce cell apoptosis. Parathyroid hormone-related peptide (PTHrP) is a locally active cytokine that enhances cell survival and is upregulated by pro-inflammatory factors in many cell types. The aim of this study was to analyze the regulation of PTHrP expression by inflammatory cytokines, and to evaluate whether PTHrP itself acts as a pro-inflammatory and/or survival factor on male murine MC in primary culture...
November 15, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29140948/hypertonic-saline-resuscitation-following-emergent-laparotomy-and-temporary-abdominal-closure
#13
Tyler J Loftus, Philip A Efron, Trina M Bala, Martin D Rosenthal, Chasen A Croft, R Stephen Smith, Frederick A Moore, Alicia M Mohr, Scott C Brakenridge
BACKGROUND: Our objective was to establish the safety of 3% hypertonic saline (HTS) resuscitation for trauma and acute care surgery patients undergoing emergent laparotomy and temporary abdominal closure (TAC) with the hypothesis that HTS administration would be associated with hyperosmolar hypercholoremic acidosis, lower resuscitation volumes, and higher fascial closure rates, without adversely affecting renal function. METHODS: We performed a retrospective cohort analysis of 189 trauma and acute care surgery patients who underwent emergent laparotomy and TAC, comparing patients with normal baseline renal function who received 3% HTS at 30 mL/h (n=36) to patients with standard resuscitation (n=153) by baseline characteristics, resuscitation parameters, and outcomes including primary fascial closure and KDIGO stages of acute kidney injury...
November 14, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29138680/enhancement-of-antioxidant-mechanisms-and-reduction-of-oxidative-stress-in-chickens-after-the-administration-of-drinking-water-enriched-with-polyphenolic-powder-from-olive-mill-waste-waters
#14
Aliki Papadopoulou, Konstantinos Petrotos, Dimitrios Stagos, Konstantinos Gerasopoulos, Antonios Maimaris, Haralampos Makris, Ioannis Kafantaris, Sotiria Makri, Efthalia Kerasioti, Maria Halabalaki, Vincent Brieudes, Georgia Ntasi, Stylianos Kokkas, Pavlos Tzimas, Panagiotis Goulas, Alexander M Zakharenko, Kirill S Golokhvast, Aristidis Tsatsakis, Demetrios Kouretas
The aim of the study was to examine the effects of a polyphenolic powder from olive mill wastewater (OMWW) administered through drinking water, on chickens' redox status. Thus, 75 chickens were divided into three groups. Group A was given just drinking water, while groups B and C were given drinking water containing 20 and 50 μg/ml of polyphenols, respectively, for 45 days. The antioxidant effects of the polyphenolic powder were assessed by measuring oxidative stress biomarkers in blood after 25 and 45 days of treatment...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29136112/local-production-of-tenascin-c-acts-as-a-trigger-for-monocyte-macrophage-recruitment-that-provokes-cardiac-dysfunction
#15
Dounia Abbadi, Fanny Laroumanie, Mathilde Bizou, Joffrey Pozzo, Danièle Daviaud, Christine Delage, Denis Calise, Fréderique Gaits-Iacovoni, Marianne Dutaur, Florence Tortosa, Edith Renaud-Gabardos, Victorine Douin-Echinard, Anne-Catherine Prats, Jerome Roncalli, Angelo Parini, Nathalie Pizzinat
Aims: Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies. Its function within pathological cardiac tissue during pressure overload remains poorly understood. Methods and results: We showed that TNC accumulates after 1 week of transverse aortic constriction (TAC) in the heart of 12-week-old male mice. By cross bone marrow transplantation experiments, we determined that TNC deposition relied on cardiac cells and not on haematopoietic cells...
November 10, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29134689/effectiveness-of-controlled-internal-drug-release-device-treatment-to-alleviate-reproductive-seasonality-in-anestrus-lactating-or-dry-barki-and-rahmani-ewes-during-non-breeding-season
#16
M Y El-Mokadem, Anm Nour El-Din, T A Ramadan, A M Rashad, T A Taha, M A Samak, M H Salem
This study aimed to evaluate the effectiveness of hormonal treatments on ovarian activity and reproductive performance in Barki and Rahmani ewes during non-breeding season. Forty-eight multiparous ewes, 24 Barki and 24 Rahmani ewes were divided into two groups, 12 lactating and 12 dry ewes for each breed. Controlled internal drug release (CIDR) device was inserted in all ewes for 14 days in conjunction with intramuscular 500 IU equine chronic gonadotrophin (eCG) at day of CIDR removal. Data were analysed using PROC MIXED of SAS for repeated measures...
November 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29132734/role-of-vitamin-e-and-d3-supplementation-in-intra-cytoplasmic-sperm-injection-outcomes-of-women-with-polycystic-ovarian-syndrome-a-double-blinded-randomized-placebo-controlled-trial
#17
Farnaz Fatemi, Afsaneh Mohammadzadeh, Mohammad Reza Sadeghi, Mohammad Mehdi Akhondi, Shayan Mohammadmoradi, Koorosh Kamali, Nicknam Lackpour, Sheida Jouhari, Simin Zafadoust, Sara Mokhtar, Ladan Giahi
BACKGROUND & AIMS: Ovulation induction has been proven to impose oxidative stress during ICSI treatment cycle. Also, data indicates that PCOS women show higher oxidative markers. Available data are not convincing about which antioxidant supplements have the potential to overcome oxidative stress in PCOS subjects. The aim of this trial was to investigate the possible role of combined vitamin E and D supplementation in the ICSI outcomes (oocyte number and quality, embryo number and quality, pregnancy rate) of PCOS subjects...
April 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29132320/histologic-chorioamnionitis-does-not-modulate-the-oxidative-stress-and-antioxidant-status-in-pregnancies-complicated-by-spontaneous-preterm-delivery
#18
Laura Fernandes Martin, Natália Prearo Moço, Moisés Diôgo de Lima, Jossimara Polettini, Hélio Amante Miot, Camila Renata Corrêa, Ramkumar Menon, Márcia Guimarães da Silva
BACKGROUND: Infection induced-inflammation and other risk factors for spontaneous preterm birth (PTB) and preterm premature rupture of membranes (pPROM) may cause a redox imbalance, increasing the release of free radicals and consuming antioxidant defenses. Oxidative stress, in turn, can initiate intracellular signaling cascades that increase the production of pro-inflammatory mediators. The objective of this study was to evaluate the oxidative damage to proteins and antioxidant capacity profiles in amniochorion membranes from preterm birth (PTB) and preterm premature rupture of membranes (pPROM) and to determine the role of histologic chorioamnionitis in this scenario...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29129702/fkbp8-protects-the-heart-from-hemodynamic-stress-by-preventing-the-accumulation-of-misfolded-proteins-and-endoplasmic-reticulum-associated-apoptosis-in-mice
#19
Tomofumi Misaka, Tomokazu Murakawa, Kazuhiko Nishida, Yosuke Omori, Manabu Taneike, Shigemiki Omiya, Chris Molenaar, Yoshihiro Uno, Osamu Yamaguchi, Junji Takeda, Ajay M Shah, Kinya Otsu
Protein quality control in cardiomyocytes is crucial to maintain cellular homeostasis. The accumulation of damaged organelles, such as mitochondria and misfolded proteins in the heart is associated with heart failure. During the process to identify novel mitochondria-specific autophagy (mitophagy) receptors, we found FK506-binding protein 8 (FKBP8), also known as FKBP38, shares similar structural characteristics with a yeast mitophagy receptor, autophagy-related 32 protein. However, knockdown of FKBP8 had no effect on mitophagy in HEK293 cells or H9c2 myocytes...
November 9, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29127547/the-effects-of-magnesium-and-zinc-co-supplementation-on-biomarkers-of-inflammation-and-oxidative-stress-and-gene-expression-related-to-inflammation-in-polycystic-ovary-syndrome-a-randomized-controlled-clinical-trial
#20
Faraneh Afshar Ebrahimi, Fatemeh Foroozanfard, Esmat Aghadavod, Fereshteh Bahmani, Zatollah Asemi
Magnesium and zinc are known to exert multiple beneficial effects including anti-inflammatory and antioxidant actions. To our knowledge, data on the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects of polycystic ovary syndrome (PCOS) are scarce. This study was conducted to evaluate the effects of magnesium and zinc co-supplementation on biomarkers of inflammation and oxidative stress and gene expression related to inflammation in subjects with PCOS...
November 10, 2017: Biological Trace Element Research
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