keyword
MENU ▼
Read by QxMD icon Read
search

TACS

keyword
https://www.readbyqxmd.com/read/27906832/clinical-validation-of-simultaneous-analysis-of-tacrolimus-cyclosporine-a-and-creatinine-in-dried-blood-spots-in-kidney-transplant-patients
#1
Herman Veenhof, Remco A Koster, Jan-Willem C Alffenaar, Stefan P Berger, Stephan J L Bakker, Daan J Touw
BACKROUND: Monitoring of creatinine and immunosuppressive drug concentrations such as tacrolimus (TaC) and cyclosporin A (CsA) is important in the outpatient follow-up of kidney transplant recipients. Monitoring by Dried Blood Spot (DBS) provides patients the opportunity to sample a drop of blood from a fingerprick at home, which can be send to the laboratory by mail. METHODS: We performed a clinical validation in which we compared measurements from whole blood samples obtained by venapuncture with measurements from DBS samples simultaneously obtained by fingerprick...
December 1, 2016: Transplantation
https://www.readbyqxmd.com/read/27905481/investigating-the-highest-melting-temperature-materials-a-laser-melting-study-of-the-tac-hfc-system
#2
Omar Cedillos-Barraza, Dario Manara, K Boboridis, Tyson Watkins, Salvatore Grasso, Daniel D Jayaseelan, Rudy J M Konings, Michael J Reece, William E Lee
TaC, HfC and their solid solutions are promising candidate materials for thermal protection structures in hypersonic vehicles because of their very high melting temperatures (>4000 K) among other properties. The melting temperatures of slightly hypostoichiometric TaC, HfC and three solid solution compositions (Ta1-xHfxC, with x = 0.8, 0.5 and 0.2) have long been identified as the highest known. In the current research, they were reassessed, for the first time in the last fifty years, using a laser heating technique...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27905214/the-association-of-plasma-oxidative-status-and-inflammation-with-the-development-of-atrial-fibrillation-in-patients-presenting-with-st-elevation-myocardial-infarction
#3
Hasan Aydin Bas, Fatih Aksoy, Atilla Icli, Ercan Varol, Abdullah Dogan, Dogan Erdogan, Ibrahim Ersoy, Akif Arslan, Hatem Ari, Nihal Bas, Recep Sutcu, Mehmet Ozaydin
Atrial fibrillation (AF) is the most common supraventricular arrhythmia following ST elevation myocardial infarction (STEMI). Oxidative stress and inflammation may cause structural and electrical remodeling in the atria making these critical processes in the pathology of AF. In this study, we aimed to evaluate the association between total oxidative status (TOS), total antioxidative capacity (TAC) and high-sensitivity C-reactive protein (hs-CRP) in the development of AF in patients presenting with STEMI. This prospective cohort study consisted of 346 patients with STEMI...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27901123/hill-number-as-a-bacterial-diversity-measure-framework-with-high-throughput-sequence-data
#4
Sanghoon Kang, Jorge L M Rodrigues, Justin P Ng, Terry J Gentry
Bacterial diversity is an important parameter for measuring bacterial contributions to the global ecosystem. However, even the task of describing bacterial diversity is challenging due to biological and technological difficulties. One of the challenges in bacterial diversity estimation is the appropriate measure of rare taxa, but the uncertainty of the size of rare biosphere is yet to be experimentally determined. One approach is using the generalized diversity, Hill number (Na), to control the variability associated with rare taxa by differentially weighing them...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900241/changes-in-the-salivary-oxidative-status-in-individuals-with-temporomandibular-disorders-and-pain
#5
Claudyane de Almeida, José Miguel Amenábar
Temporomandibular joint disorders are quite common among the general public. Free radicals may play a role in the pathogenesis of joint diseases, and the oxidative stress is an important aspect in the mechanism of TMDs. The use of new biotechnologies has enabled the use of saliva as a diagnostic method. This is the first paper that aims to investigate changes in the oxidative status, through saliva analysis, in individuals who suffer from temporomandibular disorder and pain. Sixty individuals, 54 women and 06 men, aged between 10 and 60, participated in this research...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27898857/vitamin-e-plasma-kinetics-in-swine-show-low-bioavailability-and-short-half-life-of-%C3%AE-tocopheryl-acetate
#6
T A T G van Kempen, M H Reijersen, C de Bruijn, S De Smet, J Michiels, M G Traber, C Lauridsen
Vitamin E is important for animal production because of its effects on health and product quality, but the amount and form required remains controversial. Our objective was to quantify the absolute bioavailability of oral -α-tocopheryl acetate (α-TAc) in swine (22 ± 1 kg and 8 wk old, fitted with jugular catheters) adapted to a diet supplemented with 75 mg/kg -α-TAc; 75 mg/kg was chosen because this level represents the nonweighted average inclusion level in piglet diets across Western key swine-producing countries...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895801/in-vitro-evaluation-of-a-combination-treatment-involving-anticancer-agents-and-an-aurora-kinase-b-inhibitor
#7
Senna Sakai, Hiroto Izumi, Yukiko Yoshiura, Yoshifumi Nakayama, Takahiro Yamaguchi, Yoshikazu Harada, Chiho Koi, Hiroyuki Kurata, Yasuo Morimoto
Aurora kinase B (AURKB) inhibitors are regarded as potential molecular-targeting drugs for cancer therapy. The present study evaluated the cytotoxic effect of a combination of AZD1152-hQPA, an AURKB inhibitor, and various anticancer agents on the HeLa human cervical cancer cell line, as well as its cisplatin-resistant equivalent HCP4 cell line. It was demonstrated that AZD1152-hQPA had an antagonistic effect on the cytotoxicity of cisplatin, etoposide and doxorubicin, but had a synergistic effect on that of all-trans-retinoic acid (ATRA), Am80 and TAC-101, when tested on HeLa cells...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27893819/salvianolic-acid-b-alleviates-heart-failure-by-inactivating-erk1-2-gata4-signaling-pathway-after-pressure-overload-in-mice
#8
Juan Yu, Renshan Chen, Yafang Tan, Jiashin Wu, Jianyong Qi, Minzhou Zhang, Weiwang Gu
BACKGROUND: Heart failure(HF) is a dangerous disease that affects millions of patients. Radix Salvia is widely used in Chinese clinics to treat heart diseases. Salvianolic acid B(SalB) is the major active component of Radix Salvia. This study investigated the mechanisms of action and effects of SalB on HF in an experimental mouse model of HF. METHODS: We created a mouse model of HF by inducing pressure overload with transverse aortic constriction(TAC) surgery for 2 weeks and compared among 4 study groups: SHAM group (n = 10), TAC group (n = 9), TAC+MET group (metprolol, positive drug treatment, n = 9) and TAC+SalB group (SalB, 240 mg•kg-1•day-1, n = 9)...
2016: PloS One
https://www.readbyqxmd.com/read/27893301/optimizing-the-expression-of-a-heterologous-chitinase-a-study-of-different-promoters
#9
Abigail F da Silva, Belén García-Fraga, Jacobo López-Seijas, Carmen Sieiro
Many relevant applications have been demonstrated for chitinolytic enzymes. However, their successful exploitation depends upon the availability of strains and expression conditions that allow the production of active forms and large quantities of these enzymes. Escherichia coli has been commonly used to express and overproduce different proteins, among them chitinases. Improving the functional gene expression of chitinases is key to exploiting their potential. In a recent study, we described the effect of various parameters on the functional expression of 2 chitinases from different families, demonstrating that the effect of each of these parameters on the activity of both chitinases was specific to each enzyme...
November 28, 2016: Bioengineered
https://www.readbyqxmd.com/read/27889753/renal-denervation-attenuates-multi-organ-fibrosis-and-improves-vascular-remodeling-in-rats-with-transverse-aortic-constriction-induced-cardiomyopathy
#10
Kai Wang, Dasheng Lu, Bin Zhang, Shengchan Wang, Qian Liu, Qi Zhang, Jie Geng, Qijun Shan
BACKGROUND/AIMS: To investigate the effects of renal denervation (RDN) on multi-organ fibrosis and vascular remodeling in cardiomyopathy. METHODS: Thirty-six male Sprague-Dawley rats underwent transverse aortic constriction (TAC). Five weeks later, 28 surviving TAC rats were randomly assigned to three groups: (1) RDN, (2) Sham, (3) Carvedilol. Six male Sham TAC rats served as the Control. Ten weeks after TAC, samples were collected. RESULTS: TAC rats showed an increased diastolic interventricular septal thickness at week 5...
November 25, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27888060/faith-and-oscillations-recovered-on-analyzing-eeg-meg-signals-during-tacs
#11
Toralf Neuling, Philipp Ruhnau, Nathan Weisz, Christoph S Herrmann, Gianpaolo Demarchi
Despite recent success in analyzing brain oscillations recorded during transcranial alternating current stimulation (tACS), the field still requires further research to establish standards in artifact removal methods. This includes taking a step back from the removal of the tACS artifact and thoroughly characterizing the to-be-removed artifact. A recent study by Noury et al. (2016) contributed importantly to this endeavour by showing the existence of nonlinear artefacts in the tACS signal as seen by MEG and EEG...
November 22, 2016: NeuroImage
https://www.readbyqxmd.com/read/27886143/neonatal-diesel-exhaust-particulate-exposure-does-not-predispose-mice-to-adult-cardiac-hypertrophy-or-heart-failure
#12
Yonggang Liu, Chad S Weldy, Michael T Chin
Background: We have previously reported that in utero and early life exposure to diesel exhaust particulates predisposes mice to adult heart failure, and that in utero exposure alone is sufficient to confer this predisposition. This follow up study addresses whether neonatal exposure alone can also confer this predisposition. Methods: Newborn male C57BL/6 mice were exposed to diesel exhaust (DE) particulates immediately after birth until weaning at 21 days of age, whereupon they were transferred to filtered air (FA) conditions...
November 24, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27885520/the-effect-of-pre-operative-topical-anaesthetic-cream-on-the-ablative-width-and-coagulative-depth-of-ablative-fractional-resurfacing-laser
#13
Preawphan Punyaratabandhu, Rungsima Wanitphakdeedecha, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Weeranut Phothong, Sasima Eimpunth, Visnu Lohsiriwat, Woraphong Manuskiatti
Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27881788/brain-network-mechanisms-underlying-motor-enhancement-by-transcranial-entrainment-of-gamma-oscillations
#14
Marius Moisa, Rafael Polania, Marcus Grueschow, Christian C Ruff
: Gamma and beta oscillations are routinely observed in motor-related brain circuits during movement preparation and execution. Entrainment of gamma or beta oscillations via transcranial alternating current stimulation (tACS) over primary motor cortex (M1) has opposite effects on motor performance, suggesting a causal role of these brain rhythms for motor control. However, it is largely unknown which brain mechanisms characterize these changes in motor performance brought about by tACS...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881423/association-of-systemic-arterial-properties-with-right-ventricular-morphology-the-multi-ethnic-study-of-atherosclerosis-mesa-right-ventricle-study
#15
Nadine Al-Naamani, Julio A Chirinos, Payman Zamani, Robin Ruthazer, Jessica K Paulus, Kari E Roberts, R Graham Barr, Joao A Lima, David A Bluemke, Richard Kronmal, Steven M Kawut
BACKGROUND: Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. METHODS AND RESULTS: The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end-systolic [RVESV] and end-diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi-Ethnic Study of Atherosclerosis...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881297/a-randomized-controlled-clinical-trial-investigating-the-effects-of-omega-3-fatty-acids-and-vitamin-e-co-supplementation-on-biomarkers-of-oxidative-stress-inflammation-and-pregnancy-outcomes-in-gestational-diabetes
#16
Mehri Jamilian, Shahrzad Hashemi Dizaji, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Maryam Karamali, Maryam Akbari, Zatollah Asemi
OBJECTIVES: Limited data are available for assessing the effects of omega-3 fatty acids and vitamin E co-supplementation on metabolic profiles and pregnancy outcomes in gestational diabetes (GDM). This study was designed to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on biomarkers of oxidative stress, inflammation and pregnancy outcomes in women with GDM. METHODS: This randomized, double-blind, placebo-controlled clinical trial was conducted in 60 patients with GDM who were not taking oral hypoglycemic agents...
November 21, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27880734/the-role-of-necrosis-acute-hypoxia-and-chronic-hypoxia-in-18-f-fmiso-pet-image-contrast-a-computational-modelling-study
#17
Daniel R Warren, Mike Partridge
Positron emission tomography (PET) using (18)F-fluoromisonidazole (FMISO) is a promising technique for imaging tumour hypoxia, and a potential target for radiotherapy dose-painting. However, the relationship between FMISO uptake and oxygen partial pressure ([Formula: see text]) is yet to be quantified fully. Tissue oxygenation varies over distances much smaller than clinical PET resolution (<100 μm versus  ∼4 mm), and cyclic variations in tumour perfusion have been observed on timescales shorter than typical FMISO PET studies (∼20 min versus a few hours)...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27876880/overexpression-of-serpine2-protease-nexin-1-contribute-to-pathological-cardiac-fibrosis-via-increasing-collagen-deposition
#18
Xuelian Li, Dandan Zhao, Zhenfeng Guo, Tianshi Li, Muge Qili, Bozhi Xu, Ming Qian, Haihai Liang, Xiaoqiang E, Samuel Chege Gitau, Lu Wang, Longtao Huangfu, Qiuxia Wu, Chaoqian Xu, Hongli Shan
Although increases in cardiovascular load (pressure overload) are known to elicit ventricular remodeling including cardiomyocyte hypertrophy and interstitial fibrosis, the molecular mechanisms of pressure overload or AngII -induced cardiac interstitial fibrosis remain elusive. In this study, serpinE2/protease nexin-1 was over-expressed in a cardiac fibrosis model induced by pressure-overloaded via transverse aortic constriction (TAC) in mouse. Knockdown of serpinE2 attenuates cardiac fibrosis in a mouse model of TAC...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876471/cobalamin-and-folate-protect-mitochondrial-and-contractile-functions-in-a-murine-model-of-cardiac-pressure-overload
#19
Jérôme Piquereau, Maryline Moulin, Giada Zurlo, Philippe Mateo, Mélanie Gressette, Jean-Louis Paul, Christophe Lemaire, Renée Ventura-Clapier, Vladimir Veksler, Anne Garnier
PGC-1α, a key regulator of energy metabolism, seems to be a relevant therapeutic target to rectify the energy deficit observed in heart failure (HF). Since our previous work has shown positive effects of cobalamin (Cb) on PGC-1α cascade, we investigate the protective role of Cb in pressure overload-induced myocardial dysfunction. Mice were fed with normal diet (ND) or with Cb and folate supplemented diet (SD) 3weeks before and 4weeks after transverse aortic constriction (TAC). At the end, left ventricle hypertrophy and drop of ejection fraction were significantly lower in SD mice than in ND mice...
November 19, 2016: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/27872692/protective-effects-of-vitamin-e-consumption-against-3mt-electromagnetic-field-effects-on-oxidative-parameters-in-substantia-nigra-in-rats
#20
Ahmad Ali Ghanbari, Kobra Shabani, Daryoush Mohammad Nejad
INTRODUCTION: Electromagnetic fields (EMFs) can influence the biological system by the formation of free radicals in cells. The EMFs are able to deteriorate defense system against free radicals that leads to oxidative stress (OS). Lipid peroxidation process (LPO) is an index of oxidative stress, and the Malandialdehyde (MDA) is the final product of LPO. Vitamin E is the most important antioxidant which inhibits the LPO process. The aim of this study was to evaluate the effects of 3MT EMF exposure on oxidative stress parameters in substantia nigra and the role of vitamin E in reducing oxidative stress and preventing of LPO process...
October 2016: Basic and Clinical Neuroscience
keyword
keyword
47546
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"