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https://www.readbyqxmd.com/read/29792884/pharmacological-inhibition-of-dna-methylation-attenuates-pressure-overload-induced-cardiac-hypertrophy-in-rats
#1
Justus Stenzig, Yvonne Schneeberger, Alexandra Löser, Barbara S Peters, Andreas Schaefer, Rong-Rong Zhao, Shi Ling Ng, Grit Höppner, Birgit Geertz, Marc N Hirt, Wilson Tan, Eleanor Wong, Hermann Reichenspurner, Roger S-Y Foo, Thomas Eschenhagen
BACKGROUND: Heart failure is associated with altered gene expression and DNA methylation. De novo DNA methylation is associated with gene silencing, but its role in cardiac pathology remains incompletely understood. We hypothesized that inhibition of DNA methyltransferases (DNMT) might prevent the deregulation of gene expression and the deterioration of cardiac function under pressure overload (PO). To test this hypothesis, we evaluated a DNMT inhibitor in PO in rats and analysed DNA methylation in cardiomyocytes...
May 21, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29790114/ivabradine-improved-left-ventricular-function-and-pressure-overload-induced-cardiomyocyte-apoptosis-in-a-transverse-aortic-constriction-mouse-model
#2
Yihui Yu, Zuoying Hu, Bing Li, Zhimei Wang, Shaoliang Chen
This study aimed to investigate the effects and molecular mechanisms of ivabradine in preventing cardiac hypertrophy in an established transverse aortic constriction (TAC) mouse model. A total of 56 male C57BL/6 mice were randomly assigned into the following seven groups (8 mice per group): sham, TAC model, Iva-10 (10 mg/kg/day ivabradine), Iva-20 (20 mg/kg/day ivabradine), Iva-40 (40 mg/kg/day ivabradine), Iva-80 (80 mg/kg/day ivabradine), and Rap (rapamycin, a positive control). Echocardiography and left ventricular hemodynamics were performed...
May 22, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29789611/an-intrinsic-role-of-beta-oscillations-in-memory-for-time-estimation
#3
Martin Wiener, Alomi Parikh, Arielle Krakow, H Branch Coslett
The neural mechanisms underlying time perception are of vital importance to a comprehensive understanding of behavior and cognition. Recent work has suggested a supramodal role for beta oscillations in measuring temporal intervals. However, the precise function of beta oscillations and whether their manipulation alters timing has yet to be determined. To accomplish this, we first re-analyzed two, separate EEG datasets and demonstrate that beta oscillations are associated with the retention and comparison of a memory standard for duration...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789574/helicobacter-pylori-infected-c57bl-6-mice-with-different-gastrointestinal-microbiota-have-contrasting-gastric-pathology-microbial-and-host-immune-responses
#4
Zhongming Ge, Alexander Sheh, Yan Feng, Sureshkumar Muthupalani, Lili Ge, Chuanwu Wang, Susanna Kurnick, Anthony Mannion, Mark T Whary, James G Fox
C57BL/6 (B6) mice from Taconic Sciences (Tac) and the Jackson Laboratory (Jax) were infected with H. pylori PMSS1 (Hp) for 16 week; there was no significant difference in the gastric histologic activity index between Hp infected Tac and Jax B6. However, the degree of gastric mucous metaplasia and Th1-associated IgG2c levels in response to Hp infection were increased in Tac mice over Jax mice, whereas the colonization levels of gastric Hp were higher by 8-fold in Jax B6 compared with Tac B6. Additionally, mRNA expression of gastric Il-1β, Il-17A and RegIIIγ were significantly lower in the infected Tac compared to the infected Jax mice...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29786048/cardiac-hypertrophy-is-positively-regulated-by-microrna-24-in-ratsmicrorna-24
#5
Juan Gao, Min Zhu, Rui-Feng Liu, Jian-Shu Zhang, Ming Xu
Background: MicroRNA-24 (miR-24) plays an important role in heart failure by reducing the efficiency of myocardial excitation-contraction coupling. Prolonged cardiac hypertrophy may lead to heart failure, but little is known about the role of miR-24 in cardiac hypertrophy. This study aimed to preliminarily investigate the function of miR-24 and its mechanisms in cardiac hypertrophy. Methods: Twelve Sprague-Dawley rats with a body weight of 50 ± 5 g were recruited and randomly divided into two groups: a transverse aortic constriction (TAC) group and a sham surgery group...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29786042/early-immunosuppressive-exposure-of-enteric-coated-mycophenolate-sodium-plus-tacrolimus-associated-with-acute-rejection-in-expanded-criteria-donor-kidney-transplantation
#6
Chen-Guang Ding, Li-Zi Jiao, Feng Han, He-Li Xiang, Pu-Xun Tian, Xiao-Ming Ding, Xiao-Ming Pan, Xiao-Hui Tian, Yang Li, Jin Zheng, Wu-Jun Xue
Background: Immunosuppressive agents are still inefficient in preventing biopsy-proven acute rejection (BPAR) after expanded criteria donor (ECD) kidney transplantation. The aim of this study was to investigate the relationships between early immunosuppressive exposure and the development of BPAR. Methods: We performed a retrospective study of 58 recipients of ECD kidney transplantation treated with enteric-coated-mycophenolate sodium, tacrolimus (Tac), and prednisone...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29784362/programmable-electrochemical-flow-system-for-high-throughput-determination-of-total-antioxidant-capacity
#7
Kornautchaya Veenuttranon, Loc Thai Nguyen
The aim of this work was to develop a programmable flow system for rapid assessment of total antioxidant capacity (TAC). Novel features of the prototype include a single pressure-driven source, versatile manipulation of fluid flows, ability to adapt to different TAC assays, and compatibility with microfluidic design. Antioxidant activity was determined by electrochemical measurement of residual 2,2-diphenyl-2-picrylhydrayl hydrate (DPPH•) free radicals in the solution. The overall performance of the device was validated by the spectrophotometric method...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29778870/tac-for-tavr-what-is-the-score
#8
EDITORIAL
Michael Mack, Mohanad Hamandi, Ambarish Gopal
No abstract text is available yet for this article.
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778857/development-of-a-risk-score-based-on-aortic-calcification-to-predict-1-year-mortality-after-transcatheter-aortic-valve-replacement
#9
Pierre Lantelme, Hélène Eltchaninoff, Muriel Rabilloud, Géraud Souteyrand, Marion Dupré, Marco Spaziano, Marc Bonnet, Clément Becle, Benjamin Riche, Eric Durand, Erik Bouvier, Jean-Nicolas Dacher, Pierre-Yves Courand, Lucie Cassagnes, Eduardo E Dávila Serrano, Pascal Motreff, Loic Boussel, Thierry Lefèvre, Brahim Harbaoui
OBJECTIVES: The aim of this study was to develop a new scoring system based on thoracic aortic calcification (TAC) to predict 1-year cardiovascular and all-cause mortality. BACKGROUND: A calcified aorta is often associated with poor prognosis after transcatheter aortic valve replacement (TAVR). A risk score encompassing aortic calcification may be valuable in identifying poor TAVR responders. METHODS: The C4 CAPRI (4 Cities for Assessing CAlcification PRognostic Impact) multicenter study included a training cohort (1,425 patients treated using TAVR between 2010 and 2014) and a contemporary test cohort (311 patients treated in 2015)...
May 11, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29778319/anti-infective-biomaterials-with-surface-decorated-tachyplesin-i
#10
Qiong Xue, Xiao-Bin Liu, Yeh-Hsing Lao, Lin-Ping Wu, Dong Wang, Zhen-Qiang Zuo, Jun-Yu Chen, Jing Hou, Yuan-Yuan Bei, Xue-Fei Wu, Kam W Leong, Hua Xiang, Jing Han
Implants decorated with antimicrobial peptides (AMPs) can prevent infection and reduce the risk of creating antibiotic resistance. Yet the restricted mobility of surficial AMP often compromises its activity. Here, we report a simple but effective strategy to allow a more flexible display of AMP on the biomaterial surface and demonstrate its efficacy for wound healing. The AMP, tachyplesin I (Tac), is tagged with the polyhydroxyalkanoate-granule-associated protein (PhaP) and immobilized on haloarchaea-produced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBHV) via hydrophobic interaction...
May 9, 2018: Biomaterials
https://www.readbyqxmd.com/read/29775410/apelin-and-apj-orchestrate-complex-tissue-specific-control-of-cardiomyocyte-hypertrophy-and-contractility-in-the-hypertrophy-heart-failure-transition
#11
Victoria Nicole Parikh, Jing Liu, Ching Shang, Christopher Woods, Alex Chia Yu Chang, Mingming Zhao, David N Charo, Zachary Grunwald, Yong Huang, Kinya Seo, Philip S Tsao, Daniel Bernstein, Pilar Ruiz-Lozano, Thomas Quertermous, Euan A Ashley
The G protein coupled receptor APJ is a promising therapeutic target for heart failure. Constitutive deletion of APJ in the mouse is protective against the hypertrophy-heart failure transition via elimination of ligand-independent, β-arrestin dependent stretch transduction. However, the cellular origin of this stretch transduction and the details of its interaction with apelin signaling remain unknown. We generated mice with conditional elimination of APJ in the endothelium (APJendo-/- ) and myocardium (APJmyo-/- )...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775243/protective-and-therapeutic-effects-of-dexpanthenol-on-isoproterenol-induced-cardiac-damage-in-rats
#12
Ferhat Kalkan, Hakan Parlakpinar, Olcay M Disli, Lokman H Tanriverdi, Onural Ozhan, Alaaddin Polat, Aslı Cetin, Nigar Vardi, Yılmaz O Otlu, Ahmet Acet
The purpose of the study was to explore the protective and therapeutic effects of dexpanthenol (DEX) on isoproterenol (ISO)-induced cardiac damage. Forty rats were distributed into four groups: group I (Control); group II (ISO); ISO (150 mg/kg/day) was given to rats once a day for 2 consecutive days with an interval of 24 h; group III (DEX+ISO): DEX (250 mg/kg) was applied 30 min before the first ISO administration and continued in the next two days after second ISO administration; group IV (ISO+DEX): After the ISO treatment at 1st and 2nd days, DEX was given at 3rd and 4th days...
May 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29774879/-role-of-dna-methyltransferase-1-in-mouse-skin-aging
#13
Xiangmei Ren, Xiao Xiao, Ben Wang, Yiya Zhang, Mei Yi, Ji Li, Wei Shi
To explore the role ofDNA methyltransferase 1 (DNMT1) in mouse skin aging.
 Methods: Epidermal conditional K14 Cre-mediated DNA methyltransferase 1 (DNMT1) knockout mice (Mut group, n=4) and the littermate normal mice with the same age (WT group) n=4) were used in this study. HE staining was used to detect the pathological changes of skin; the changes of number in the dermal elastic fibers were detected by Gomori aldehyde fuchsin staining, the number of 5-bromo-2-deoxyuridine (BrdU)-labeled transit amplifying cells (TAC) in epidermis were detected by immunohistochemical staining; the number of chlorodeoxyuridine (CldU)-label-retaining cells (LRC) in epidermis were detected by immunofluorescent staining...
April 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29773131/acute-phase-proteins-interleukin-6-tumor-necrosis-factor-nitric-oxide-and-oxidative-stress-markers-in-horses-with-cutaneous-habronemosis-under-field-condition
#14
W El-Deeb, O Iacob, M Fayez, M Elgioushy, T Shawaf, A Ibrahim
Habronemosis is a common parasitic disease of horses worldwide. In order to investigate how haptoglobin (Hp), serum amyloid A (SAA), oxidative stress markers, nitric oxide (NO), interleukin-6 (IL-6) and tumor necrosis factor (TNF- α), varies in cutaneous habronemosis, 30 horses with the clinical disease and 20 clinically healthy horses were included in the current study. The serum levels of Hp, SAA, and proinflammatory cytokines (IL-6 and TNF-α), NO, malondialdehyde (MDA), super oxide dismutase (SOD), glutathione (GSH), and total antioxidant capacity (TAC) were determined in horses before and after two weeks of treatment...
May 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29772440/inhibition-of-nogo-b-promotes-cardiac-hypertrophy-via-endoplasmic-reticulum-stress
#15
Junli Li, Wenchao Wu, Yanguo Xin, Mingyue Zhao, Xiaojing Liu
AIMS: Nogo-B is a key endoplasmic reticulum (ER) protein that regulates ER stress signaling. However, its role in cardiac hypertrophy remains poorly understood. ER stress is interrelated with autophagy in the process of cardiac hypertrophy. Therefore, we aimed to test the hypothesis that both ER stress and autophagy signaling mediate the function of Nogo-B in cardiac hypertrophy. MAIN METHODS: Rat models of transverse aortic constriction (TAC), neonatal rat cardiomyocytes (NRCMs) stimulated with norepinephrine (Ne) and primary cardiac fibroblasts treated with transforming growth factor β1 (TGF-β1) were used in this study...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29771428/ampk-regulates-energy-metabolism-through-the-sirt1-signaling-pathway-to-improve-myocardial-hypertrophy
#16
H-W Dong, L-F Zhang, S-L Bao
OBJECTIVE: We investigated the correlations of adenosine monophosphate-activated protein kinase (AMPK), Silence information regulator 1 (SIRT1) and energy metabolism with myocardial hypertrophy. MATERIALS AND METHODS: Myocardial hypertrophy experimental model was established via transverse aortic constriction (TAC)-induced myocardial hypertrophy and phenylephrine (PE)-induced hypertrophic myocardial cell culture. After activation of AMPK, the messenger ribonucleic acid (mRNA) expressions in myocardial tissue- and myocardial cell hypertrophy-related genes, atrial natriuretic peptide (ANP) and β-myosin heavy chain (β-MHC), were detected...
May 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29770168/blood-and-tissue-enzymatic-activities-of-gdh-and-ldh-index-of-glutathione-and-oxidative-stress-among-breast-cancer-patients-attending-referral-hospitals-of-addis-ababa-ethiopia-hospital-based-comparative-cross-sectional-study
#17
Mohammed Mehdi, M K C Menon, Nebiyou Seyoum, Mahteme Bekele, Wondimagegn Tigeneh, Daniel Seifu
The exact cause of breast cancer is unknown; it is a multifactorial disease. It is the most diagnosed and the second killer cancer among women. Breast cancer can be originated from tissues of breast or secondary from other organs via metastasis. Generally, cancer cells show aberrant metabolism and oxidative stress when compared to noncancerous tissues of breast cancer patients. The current study aims at evaluating glutamate and glucose metabolism through GDH and LDH enzyme activities, oxidant, and antioxidative status among breast cancer patients attending referral hospitals of Addis Ababa, Ethiopia...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29768130/super-pill-is-less-effective-than-an-ordinary-mint-in-altering-subjective-psychological-feeling-states-within-a-few-minutes
#18
Attila Szabo, Lilla Jobbágy, Ferenc Köteles
Expectations shape human behavior. Initial drug use might be associated with information-based expectations. In this study, we presumed that changes in affect and perceived physical wellbeing will be stronger after receiving an active placebo (Tic Tac mint; n = 40), than a pure placebo (inert pill; n = 40) given as a mood-enhancing "super pill." After baseline measures, participants completed a treatment-expectancy scale, ingested the mint/super pill, and attended to the effects over 3-minutes. Subsequently, they completed again the psychological tests...
April 2018: Journal of General Psychology
https://www.readbyqxmd.com/read/29767099/growth-performance-nutrient-digestibility-antioxidant-capacity-blood-biochemical-biomarkers-and-cytokines-expression-in-broiler-chickens-fed-different-phytogenic-levels
#19
Vasileios Paraskeuas, Konstantinos Fegeros, Irida Palamidi, Christine Hunger, Konstantinos C Mountzouris
The effects of inclusion levels of a phytogenic feed additive (PFA), characterized by menthol anethol and eugenol, on broiler growth performance, nutrient digestibility, biochemical biomarkers and total antioxidant capacity (TAC) of plasma and meat, as well as on the relative expression of selected cytokines, were studied in a 42-d experiment. A total of 225 one-day-old male Cobb broiler chickens were assigned into 3 treatments, with 5 replicates of 15 chickens each. Chickens were fed maize-soybean meal basal diets following a 3 phase (i...
June 2017: Animal nutrition
https://www.readbyqxmd.com/read/29766146/the-effect-of-resveratrol-on-oxidative-stress-in-the-liver-and-serum-of-a-rat-model-of-polycystic-ovary-syndrome-an-experimental-study
#20
Mahnaz Ghowsi, Homayoun Khazali, Sajjad Sisakhtnezhad
Background: Studies of oxidative status in polycystic ovarian syndrome (PCOS) patients are limited with inconsistent results. The effects of resveratrol as a natural antioxidant on oxidative status in PCOS aren't clear. Objective: This study evaluated effects of resveratrol on oxidative stress in the liver and serum of the PCOS rats. Materials and Methods: Fifteen female Wistar rats (3 wk old) were divided into 3 groups (n=5/each e): Control group, PCO-Control group, and PCO-Resveratrol group...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
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