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https://www.readbyqxmd.com/read/28230715/a-multireferral-centre-retrospective-cohort-analysis-on-the-experience-in-treatment-of-metastatic-uveal-melanoma-and-utilization-of-sequential-liver-directed-treatment-and-immunotherapy
#1
Malinda Itchins, Paolo A Ascierto, Alexander M Menzies, Meredith Oatley, Serigne Lo, Dariush Douraghi-Zadeh, Timmothy Harrington, Richard Maher, Antonio M Grimaldi, Alexander Guminski
Metastatic uveal melanoma is a rare malignancy with a poor prognosis. To date, systemic therapy has been ineffective; however, there are few data on the benefits of anti-CTLA4 or anti-PD-1 antibodies in sequence with liver-directed therapy. A retrospective cohort analysis was carried out on 37 consecutive patients managed in a tertiary referral centre examining the safety and efficacy of treatment; patterns of care; and impact on survival. The sequential treatment with transarterial chemotherapy (TAC), systemic immunotherapy (IT) and systemic chemotherapy was reviewed...
February 22, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28230244/topical-anaesthetics-for-pain-control-during-repair-of-dermal-laceration
#2
REVIEW
Baraa O Tayeb, Anthony Eidelman, Cristy L Eidelman, Ewan D McNicol, Daniel B Carr
BACKGROUND: Topical local anaesthetics provide effective analgesia for patients undergoing numerous superficial procedures, including repair of dermal lacerations. The need for cocaine in topical anaesthetic formulations has been questioned because of concern about adverse effects, thus novel preparations of cocaine-free anaesthetics have been developed. This review was originally published in 2011 and has been updated in 2017. OBJECTIVES: To assess whether benefits of non-invasive topical anaesthetic application occur at the expense of decreased analgesic efficacy...
February 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28229230/mycobacterium-ulcerans-mycolactone-interferes-with-adhesion-migration-and-proliferation-of-primary-human-keratinocytes-and-hacat-cell-line
#3
Francesca Graziola, Elena Colombo, Rossana Tiberio, Giorgio Leigheb, Chiarella Bozzo
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential activities on two primary human keratinocyte populations, keratinocyte stem cells (KSC) and transit amplifying cells (TAC), and on a human keratinocyte line, HaCaT. We demonstrated that 0.01 and 0...
February 22, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28228580/probing-phase-and-frequency-dependent-characteristics-of-cortical-neurons-using-combined-transcranial-alternating-current-stimulation-and-transcranial-magnetic
#4
Sara Jeanne Hussain, Nivethida Thirugnanasambandam
Paired-pulse transcranial magnetic stimulation (TMS) and peripheral stimulation combined with TMS can be used to study cortical interneuronal circuitry. By combining these procedures with concurrent transcranial alternating current stimulation (tACS), Guerra and colleagues recently showed that different cortical interneuronal populations are differentially modulated by the phase and frequency of tACS-imposed oscillations (Guerra et al. 2016, Phase dependency of the human primary motor cortex and cholinergic inhibition cancellation during beta tACS, Cerebral Cortex 26:3977-2990)...
February 22, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28228207/complications-and-mortality-associated-with-temporary-abdominal-closure-techniques-a-systematic-review-and-meta-analysis
#5
Adam Cristaudo, Scott Jennings, Ronny Gunnarsson, Alan DeCosta
Temporary abdominal closure (TAC) techniques are routinely used in the open abdomen. Ideally, they should prevent evisceration, aid in removal of unwanted fluid from the peritoneal cavity, facilitate in achieving safe definitive fascial closure, as well as prevent the development of intra-abdominal complications. TAC techniques used in the open abdomen were compared with negative pressure wound therapy (NPWT) to identify which was superior. A systematic review was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines involving Medline, Excerpta Medica, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature, and <ext-link ext-link-type="uri" xlink:href="http://Clinicaltrials...
February 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28227966/real-time-evaluation-of-a-myoelectric-control-method-for-high-level-upper-limb-amputees-based-on-homologous-leg-movements
#6
Kenneth R Lyons, Sanjay S Joshi, Kenneth R Lyons, Sanjay S Joshi, Sanjay S Joshi, Kenneth R Lyons
Electromyography-based gesture classification methods for control of advanced upper limb prostheses are limited either to individuals with amputations distal to the elbow or to those willing to undergo targeted muscle reinnervation surgery. Based on the natural similarity between gestures of the lower leg and the arm and on established methods in electromyography-based gesture classification, we propose a noninvasive system with which users control an upper limb prosthesis via homologous movements of the leg and foot...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226322/chronic-administration-of-rosa-canina-hydro-alcoholic-extract-attenuates-depressive-like-behavior-and-recognition-memory-impairment-in-diabetic-mice-a-possible-role-of-oxidative-stress
#7
Ramin Farajpour, Saeed Sadigh-Eteghad, Nahid Ahmadian, Mohammad Farzipour, Javad Mahmoudi, Alireza Majdi
OBJECTIVE: This study was designed to evaluate whether or not chronic Rosa Canina (RC) extract administration could improve recognition memory and depressive-like behaviour in diabetic mice. MATERIALS AND METHODS: Seventy-five (75) male Albino mice (25-30 g) were randomly divided into five groups (15 in each group). A single intraperitoneal (ip) injection of 200 mg/kg streptozotocin (STZ) was administered to the mice to induce diabetes. The control group received normal saline, and the diabetic groups received normal saline or 50, 250 and 500 mg/kg of RC extract for 28 days...
February 22, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28225647/early-experience-with-single-incision-laparoscopic-total-abdominal-colectomy-in-children
#8
Cristen N Litz, Paul D Danielson, Nicole M Chandler
PURPOSE: Single-incision laparoscopic surgery for pediatric colorectal disease has been shown to be feasible and safe; however, the literature is scarce regarding the outcomes of single-incision laparoscopic total abdominal colectomy (SIL-TAC) in the pediatric population. The purpose of this pilot study was to review our initial experience and outcomes with SIL-TAC. MATERIALS AND METHODS: A retrospective review of patients who underwent SIL-TAC from 2013 to 2015 was performed...
February 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28225488/association-between-beat-to-beat-blood-pressure-variability-and-vascular-elasticity-in-normal-young-adults-during-the-cold-pressor-test
#9
Yufa Xia, Dan Wu, Zhifan Gao, Xin Liu, Qian Chen, Lijie Ren, Wanqing Wu
The beat-to-beat blood pressure (BP) monitoring parameters, such as average beat-to-beat BP, BP variability (BPV), could have an influence on the vascular elasticity. This study hypothesized that the elevated beat-to-beat BPV could evoke the reduction of the vascular elasticity independent of BP levels. We measured the beat-to-beat BP recordings and total arterial compliance (TAC), which was used to assess the vascular elasticity, in 80 young healthy adults during the cold pressor test (CPT). The CPT included 3 phases: baseline phase, cold stimulus phase, recovery phase...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28224651/supplementing-oregano-essential-oil-to-boar-diet-with-strengthened-fish-oil-effects-on-semen-antioxidant-status-and-semen-quality-parameters
#10
Q Liu, R J Duan, Y F Zhou, H K Wei, J Peng, J L Li
Previous research has shown benefits of dietary fish oil supplementation on semen quality of boars. However, little is known about how antioxidant protects lipid peroxidation on spermatozoa from n-3 polyunsaturated fatty acid (PUFA) addition. This study evaluated the effect of oregano essential oil (OEO) supplementation on semen antioxidant status and semen quality in boars fed a diet enriched with fish oil. Thirty-four mature boars of proven fertility, received daily 2.5 kg basal diet top-dressed with 45 g soybean oil and 15 g fish oil to meet the n-3 PUFA requirement of spermatozoa, randomly allocated to one of four groups supplemented with 100 mg α-tocopheryl acetate kg(-1) (control), or 250 or 500 or 750 mg OEO kg(-1) for 16 weeks...
February 22, 2017: Andrologia
https://www.readbyqxmd.com/read/28223222/disrupting-the-key-circadian-regulator-clock-leads-to-age-dependent-cardiovascular-disease
#11
Faisal J Alibhai, Jonathan LaMarre, Cristine J Reitz, Elena V Tsimakouridze, Jeffrey T Kroetsch, Steffen-Sebastian Bolz, Alex Shulman, Samantha Steinberg, Thomas P Burris, Gavin Y Oudit, Tami A Martino
The circadian mechanism underlies daily rhythms in cardiovascular physiology and rhythm disruption is a major risk factor for heart disease and worse outcomes. However, the role of circadian rhythms is generally clinically unappreciated. Clock is a core component of the circadian mechanism and here we examine the role of Clock as a vital determinant of cardiac physiology and pathophysiology in aging. Clock(Δ19/Δ19) mice develop age-dependent increases in heart weight, hypertrophy, dilation, impaired contractility, and reduced myogenic responsiveness...
February 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28223040/red-blood-cell-exchange-as-an-approach-for-treating-a-case-of-severe-tacrolimus-overexposure
#12
Valentina Spallanzani, Lucia Bindi, Irene Bianco, Arianna Precisi, Paolo DeSimone, Alessandro Mazzoni, Gianni Biancofiore
Immunosuppressive medication dosing errors are not unfrequent and may present a number of challenges to transplant clinicians. Tacrolimus (TAC) is a widely used immunosuppressant with a narrow therapeutic index and potential severe side effects, including neurotoxicity and kidney injury. We herein report a case of 60-year-old woman who underwent deceased-donor liver transplantation at our center and due to inadvertent TAC overexposure was admitted to the Intensive Care Unit because of severe neurologic impairment, kidney injury and arterial hypotension...
February 2, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28222232/dietary-total-antioxidant-capacity-in-early-school-age-and-subsequent-allergic-disease
#13
Anna Gref, Susanne Rautiainen, Olena Gruzieva, Niclas Håkansson, Inger Kull, Göran Pershagen, Magnus Wickman, Alicja Wolk, Erik Melén, Anna Bergström
BACKGROUND: Dietary antioxidant intake has been hypothesized to influence the development of allergic diseases, however, few prospective studies have investigated this association. OBJECTIVE: Our aim was to study the association between total antioxidant capacity (TAC) of the diet at age 8 years and the subsequent development of asthma, rhinitis and sensitization to inhalant allergens between 8 and 16 years, and to assess potential effect modification by known risk factors...
February 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28222041/a-comparison-of-short-term-therapeutic-efficacy-between-infliximab-and-tacrolimus-for-moderate-to-severe-ulcerative-colitis
#14
Hirokazu Yamagami, Yu Nishida, Yasuaki Nagami, Shuhei Hosomi, Tomomi Yukawa, Koji Otani, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Yasuhiro Fujiwara
INTRODUCTION: Both infliximab (IFX) and tacrolimus (Tac) are effective for inducing clinical remission in patients with ulcerative colitis (UC). However no randomized study has addressed the relative efficacies of IFX and Tac for patients with moderate to severe UC. This study aimed to conduct a retrospective study on the relative efficacy of IFX and Tac in patients with moderate to severe UC, using an inverse probability of treatment weighting (IPTW) technique to adjust background factors statistically...
February 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28220265/similarities-and-differences-between-behavioral-and-electrophysiological-visual-acuity-thresholds-in-healthy-infants-during-the-second-half-of-the-first-year-of-life
#15
Claudia Polevoy, Gina Muckle, Jean R Séguin, Emmanuel Ouellet, Dave Saint-Amour
PURPOSE: Behavioral and electrophysiological methods for visual acuity estimation typically correlate well in children and adult populations, but this relationship remains unclear in infants, particularly during the second half of the first year of life. It has been suggested that the agreement between both methods mostly relies on age and/or subjective acuity factors. The present study aimed at comparing acuity thresholds obtained with both approaches in a sample of healthy infants in a relatively narrow age range, that is 6-10 months old...
February 20, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28219583/risk-factors-affecting-graft-and-patient-survivals-after-transplantation-from-deceased-donors-in-a-developing-country-a-single-center-experience
#16
Y Ayar, A Ersoy, G Ocakoglu, A Yildiz, A Oruc, H Soyak, M Calapkulu, A B Sahin, N Bolca Topal, E Okeer, B Coskun, O Kaygisiz, Y Kordan, H Vuruskan
AIM: The aim of this study was to evaluate risk factors affecting graft and patient survival after transplantation from deceased donors. METHODS: We retrospectively analyzed the outcomes of 186 transplantations from deceased donors performed at our center between 2006 and 2014. The recipients were divided into two groups: Group I (141 recipients without graft loss) and Group II (45 recipients with graft loss). Kaplan-Meier, log-rank test, and Cox proportional hazard regressions were used...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28217258/antioxidant-effects-of-aqueous-extract-of-salep-on-paraquat-induced-rat-liver-injury
#17
Shekoufeh Atashpour, Hossein Kargar Jahromi, Zahra Kargar Jahromi, Sanaz Zarei
AIM: To evaluate the effects of aqueous extract of Salep on Paraquat-mediated liver injury. METHODS: In this experimental study, 56 adult male Wistar rats were divided randomly to 7 groups as control, sham, and 5 experimental groups. In control group, rats did not receive any substance during experiment. In Sham group, rats were given distilled water according to their body weight and in experimental groups, Paraquat alone and with different doses of Salep aqueous extract (40, 80, 160 and 320 mg/kg) was given intraperitoneal daily for 14 d...
February 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28212265/variations-in-oxidative-stress-levels-in-3-days-follow-up-in-ultramarathon-mountain-race-athletes
#18
Ypatios Spanidis, Dimitrios Stagos, Marina Orfanou, Nikolaos Goutzourelas, David Bar-Or, Demetrios Spandidos, Demetrios Kouretas
Spanidis, Y, Stagos, D, Orfanou, M, Goutzourelas, N, Bar-or, D, Spandidos, D, and Kouretas, D. Variations in oxidative stress levels in 3 days follow-up in ultramarathon mountain race athletes. J Strength Cond Res 31(3): 582-594, 2017-The aim of the present study was the monitoring of the redox status of runners participating in a mountain ultramarathon race of 103 km. Blood samples from 12 runners were collected prerace and 24, 48, and 72 hours postrace. The samples were analyzed by using conventional oxidative stress markers, such as protein carbonyls (CARB), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC) in plasma, as well as glutathione (GSH) levels and catalase (CAT) activity in erythrocytes...
March 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28209906/first-evaluation-of-pet-based-human-biodistribution-and-dosimetry-of-18-f-faza-a-tracer-for-imaging-tumor-hypoxia
#19
Savi Annarita, Elena Incerti, Federico Fallanca, Valentino Bettinardi, Francesca Rossetti, Cristina Monterisi, Antonia Compierchio, Giampiero Negri, Piero Zannini, Luigi Gianolli, Maria Picchio
Fluorine-18 labelled fluoroazomycinarabinoside ((18)F-FAZA) is a positron emission tomography (PET) biomarker for non-invasive identification of regional tumor hypoxia. Aim of the present Phase I study was to firstly evaluate in non-small cell lung cancer patients the human biodistribution and dosimetry of (18)F-FAZA. Methods: Five patients awaiting surgical resection after histologically proven or radiologically suspected non-small cell lung cancer were prospectively enrolled for the study. The patients underwent a PET/computed tomography (CT) study after the injection of 371±32 MBq of (18)F-FAZA...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28207414/anti-aging-effects-of-m2000-%C3%AE-d-mannuronic-acid-as-a-novel-immunosuppressive-drug-on-the-enzymatic-and-non-enzymatic-oxidative-stress-parameters-in-an-experimental-model
#20
Soma Hosseini, Mohammad Abdollahi, Gholamreza Azizi, Mohammad Javad Fattahi, Noshin Rastkari, Farzaneh Tofighi Zavareh, Zahra Aghazadeh, Abbas Mirshafiey
BACKGROUND: The anti-aging property of β-D-mannuronic acid (M2000) as a novel non-steroidal anti-inflammatory and immunosuppressive agent was investigated on several determinants relative to the oxidative stress in an animal model. MATERIALS AND METHODS: Sprague-Dawley rats were used for evaluating the safety and efficacy properties of M2000 on some oxidative stress enzymes, including the following: mitochondrial superoxide dismutase (SOD2), catalase (CAT), glutathione peroxidase (GPX1), glutathione S-transferase (GST), myeloperoxidase (MPO), and inducible nitric oxide synthase (iNOS) gene expression by real-time PCR...
February 16, 2017: Journal of Basic and Clinical Physiology and Pharmacology
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