keyword
MENU ▼
Read by QxMD icon Read
search

ketosis diabet

keyword
https://www.readbyqxmd.com/read/29847735/optimization-of-insulin-regimen-and-glucose-outcomes-with-short-term-real-time-continuous-glucose-monitoring-in-adult-type-1-diabetic-patients-with-suboptimal-control-on-multiple-daily-injections-the-adult-diaccor-study
#1
Sylvie Picard, Hélène Hanaire, Yves Reznik, Pierre-Yves Benhamou, Salha Fendri, Lise Dufaitre, Eric Leutenegger, Bruno Guerci
BACKGROUND: The impact of a 7-day real-time continuous glucose monitoring (RT-CGM) on type 1 diabetes (T1D) management remains unclear in patients suboptimally controlled by multiple daily injections (MDI). The DIACCOR Study aimed to describe treatment decisions and glucose outcomes after a short-term RT-CGM sequence. PATIENTS AND METHODS: This French multicenter longitudinal observational study included T1D patients with HbA1c >7.5% or history of severe hypoglycemia (SH) or recurrent documented hypoglycemia...
May 30, 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29770221/risperidone-induced-type-2-diabetes-presenting-with-diabetic-ketoacidosis
#2
Clarissa Ern Hui Fang, Mohammed Faraz Rafey, Aine Cunningham, Sean F Dinneen, Francis M Finucane
A 28-year-old male presented with 2 days of vomiting and abdominal pain, preceded by 2 weeks of thirst, polyuria and polydipsia. He had recently started risperidone for obsessive-compulsive disorder. He reported a high dietary sugar intake and had a strong family history of type 2 diabetes mellitus (T2DM). On admission, he was tachycardic, tachypnoeic and drowsy with a Glasgow Coma Scale (GCS) of 10/15. We noted axillary acanthosis nigricans and obesity (BMI 33.2 kg/m2 ). Dipstick urinalysis showed ketonuria and glycosuria...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29748034/ampk-induced-memory-improvements-in-the-diabetic-population-a-case-study
#3
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
April 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29712560/cardiovascular-disease-risk-factor-responses-to-a-type-2-diabetes-care-model-including-nutritional-ketosis-induced-by-sustained-carbohydrate-restriction-at-1-year-an-open-label-non-randomized-controlled-study
#4
Nasir H Bhanpuri, Sarah J Hallberg, Paul T Williams, Amy L McKenzie, Kevin D Ballard, Wayne W Campbell, James P McCarter, Stephen D Phinney, Jeff S Volek
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of death among adults with type 2 diabetes mellitus (T2D). We recently reported that glycemic control in patients with T2D can be significantly improved through a continuous care intervention (CCI) including nutritional ketosis. The purpose of this study was to examine CVD risk factors in this cohort. METHODS: We investigated CVD risk factors in patients with T2D who participated in a 1 year open label, non-randomized, controlled study...
May 1, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29707905/human-herpes-virus-type-8-infection-dna-positivity-is-associated-with-low-insulin-secretion-a-case-control-study-in-a-sub-saharan-african-population-with-diabetes
#5
Eric Lontchi-Yimagou, Jérôme Legoff, Jean-Louis Nguewa, Philippe Boudou, Eric V Balti, Jean Jacques Noubiap, Vicky Kamwa, Barbara Atogho-Tiedeu, Marcel Azabji-Kenfack, Eric N Djahmeni, Martine Etoa, Gaelle Lemdjo, Vanessa Balla, Mesmin Y Dehayem, Fabienne Foufelle, Jean-Claude Mbanya, Jean-Francois Gautier, Eugene Sobngwi
BACKGROUND: Viruses have been considered as potential triggers for diabetes development. This study sought to assess insulin secretion and insulin sensitivity in Human Herpes Virus type 8 (HHV8) infected and non-infected sub-Saharan African people with diabetes. METHODS: We consecutively enrolled 173 people with non-autoimmune diabetes: 124 with type 2 diabetes (T2D), and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycaemic crisis. KPD was further sub-classified as new-onset ketotic phase KPD (n=34) or non-ketotic phase KPD (n=15)...
April 29, 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29706815/acute-pancreatitis-secondary-to-hypertriglyceridemia-precipitated-by-diabetic-ketoacidosis-in-a-previously-undiagnosed-ketosis-prone-patient-with-diabetes-mellitus
#6
Vignesh Ramachandran, Diana M Vila, John M Cochran, Andrew C Caruso, Rajeev Balchandani
Diabetic ketoacidosis is a potentially fatal complication of diabetes mellitus that may result in hypertriglyceridemia. Rarely, the resulting hypertriglyceridemia may precipitate acute pancreatitis. We report a case of acute pancreatitis secondary to hypertriglyceridemia precipitated by diabetic ketoacidosis and postulate that this unusual presentation is due to the patient being prone to ketosis.
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29697540/ketone-bodies-as-epigenetic-modifiers
#7
Hai-Bin Ruan, Peter A Crawford
PURPOSE OF REVIEW: Ketone body metabolism is a dynamic and integrated metabolic node in human physiology, whose roles include but extend beyond alternative fuel provision during carbohydrate restriction. Here we discuss the most recent observations suggesting that ketosis coordinates cellular function via epigenomic regulation. RECENT FINDINGS: Ketosis has been linked to covalent modifications, including lysine acetylation, methylation, and hydroxybutyrylation, to key histones that serve as dynamic regulators of chromatin architecture and gene transcription...
July 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29688432/glucagonoma-with-necrolytic-migratory-erythema-metabolic-profile-and-detection-of-biallelic-inactivation-of-daxx-gene
#8
Ai Tamura, Tatsuki Ogasawara, Yoichi Fujii, Hiyori Kaneko, Akitoshi Nakayama, Seiichiro Higuchi, Naoko Hashimoto, Yui Miyabayashi, Masanori Fujimoto, Eri Komai, Takashi Kono, Ikki Sakuma, Hidekazu Nagano, Sawako Suzuki, Hisashi Koide, Koutaro Yokote, Kozue Iseki, Rena Oguma, Hiroyuki Matsue, Hiroyuki Nojima, Kensuke Sugiura, Hideyuki Yoshitomi, Masayuki Ohtsuka, Bahityar Rahmutulla, Atsushi Kaneda, Naoko Inoshita, Seishi Ogawa, Tomoaki Tanaka
Context: Necrolytic migratory erythema (NME) occurs in approximately 70% of patients with glucagonoma syndrome. Excessive stimulation of metabolic pathways by hyperglucagonemia, which leads to hypoaminoacidemia, contributes to NME pathogenesis. However, the molecular pathogenesis of glucagonoma and relationships between metabolic abnormalities and clinical symptoms remain unclear. Case description: A 53-year-old woman was referred to our hospital with a generalized rash and weight loss...
April 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29607218/nutritional-ketosis-and-mitohormesis-potential-implications-for-mitochondrial-function-and-human-health
#9
REVIEW
Vincent J Miller, Frederick A Villamena, Jeff S Volek
Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diabetes, neurodegenerative disorders, and cancer. Moderate levels of mitochondrial ROS, however, can protect against chronic disease by inducing upregulation of mitochondrial capacity and endogenous antioxidant defense. This phenomenon, referred to as mitohormesis, is induced through increased reliance on mitochondrial respiration, which can occur through diet or exercise...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29602453/sglt2-inhibitor-induced-euglycaemic-diabetic-ketoacidosis-may-be-due-to-abrupt-severe-and-transient-impaired-glucose-sensing-in-susceptible-individuals-with-a-hitherto-unrecognised-beta-cell-sglt-variant
#10
F M Finucane
Euglycaemic diabetic ketoacidosis (EDKA) is a rare complication of treatment with SGLT2 inhibitors in patients with type 2 diabetes. Uncertainty remains about its precise mechanistic basis, but the physiological derangement is acute and profound, yet reversible with cessation of the drug. It is reminiscent of other "non type 1" presentations with DKA such as ketosis prone diabetes, except that glucose levels are usually normal. Impaired beta cell glucose sensing that mimicked a state of hypoglycaemia could theoretically lead to abrupt and transient cessation of insulin secretion...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29600506/prediabetes-directly-deteriorates-into-diabetic-ketoacidosis-and-hyperosmolar-hyperglycemic-syndrome-triggered-by-acute-pancreatitis-a-case-report-illustrating-a-chicken-and-egg-paradigm-in-ketosis-prone-diabetes
#11
Runbo Song, Shanjin Cao
INTRODUCTION: Diabetic crises occur most often in patients with type 1 diabetes and occasionally in type 2 diabetes, especially under stressful conditions. However, a diabetic crisis occurring directly from prediabetes is an unusual phenomenon. CASE REPORT: A 45-year-old woman presented with postprandial left upper quadrant abdominal pain, nausea, and vomiting. She had a past medical history of prediabetes with impaired fasting glucose and HbA1c 6.4%. On admission, routine laboratory tests showed high anion gap metabolic acidosis (pH 6...
March 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29573166/suboptimal-behaviour-and-knowledge-regarding-overnight-glycaemia-in-adults-with-type-1-diabetes-is-common
#12
Christina R Larsson, Andrzej S Januszewski, Rachel T McGrath, Johnny Ludvigsson, Anthony C Keech, Richard J MacIsaac, Glenn M Ward, David N O'Neal, Gregory R Fulcher, Alicia J Jenkins
BACKGROUND: In people with Type 1 diabetes (T1D) nocturnal hypoglycaemia (NH) can be slept through, and can cause seizures, arrhythmias and death. Hypoglycaemia avoidance can induce hyperglycaemia and ketosis. Patient behaviour impacts clinical outcomes and may be changed by education. AIM: To develop and utilise a survey to evaluate patient self-management of overnight glycaemia in adults with Type 1 Diabetes (T1D). METHODS: Adults with T1D attending two Australian tertiary referral diabetes clinics completed a survey about their diabetes self-management and glycaemic control, including their responses to hypothetical pre-bed blood glucose (BG) levels (4-20mmol/L)...
March 23, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29555548/postoperative-period
#13
(no author information available yet)
Follow on from continuous intravenous administration of insulin with an electronic syringe (IVES) is an important element in the postoperative management of a diabetic patient. The basal-bolus scheme is the most suitable taking into account the nutritional supply and variable needs for insulin, reproducing the physiology of a normal pancreas: (i) slow (long-acting) insulin (=basal) which should immediately take over from IVES insulin simulating basal secretion; (ii) ultra-rapid insulin to simulate prandial secretion (=bolus for the meal); and (iii) correction of possible hyperglycaemia with an additional ultra-rapid insulin bolus dose...
March 16, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29513157/use-of-lispro-insulin-for-treatment-of-diabetic-ketoacidosis-in-cats
#14
Eleonora Malerba, Michela Mazzarino, Francesca Del Baldo, Sara Corradini, Gaia Carotenuto, Massimo Giunti, Federico Fracassi
Objectives The aim of this study was to evaluate the efficacy and safety of lispro insulin for the treatment of feline diabetic ketoacidosis (DKA). Times to resolution of hyperglycaemia, ketosis and acidosis were compared between cats treated with continuous rate infusion (CRI) of lispro insulin and cats treated with CRI of regular insulin. Methods Client-owned cats with naturally occurring DKA, newly diagnosed with diabetes mellitus (DM) or already receiving treatment for DM, were included. Diagnosis of DKA involved the presence of at least two clinical signs consistent with DKA (eg, polyuria/polydipsia, anorexia, severe lethargy, vomiting and dehydration), blood glucose (BG) concentration >13...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29510081/vildagliptin-pioglitazone-combination-improved-the-overall-glycemic-control-in-type-i-diabetic-rats
#15
Amir M Abdelhamid, Rania Ramadan Abdelaziz, Hatem A Salem
Type I diabetes (TID) is generally assumed to be caused by an immune associated, if not directly immune-mediated, destruction of pancreatic β-cells. In patients with long-term diabetes, the pancreas lacks insulin-producing cells and the residual β-cells are unable to regenerate. Patients with TID are subjected to a lifelong insulin therapy which shows risks of hypoglycemia, suboptimal control and ketosis. In this study, we investigated the potential role of Vildagliptin (Vilda) alone or in combination with Pioglitazone (Pio), as treatment regimens for TID using Streptozotocin (STZ) induced TID model in rats...
March 6, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29505160/management-of-type-1-diabetes-should-be-different-from-type-2-diabetes-at-hospital-admission
#16
LETTER
H K Akturk
No abstract text is available yet for this article.
June 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29490106/arginine-metabolism-and-a-%C3%AE-ketosis-prone-diabetes
#17
Michael S Boyne
No abstract text is available yet for this article.
February 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29490093/arginine-metabolism-is-altered-in-adults-with-a-%C3%AE-ketosis-prone-diabetes
#18
Surya N Mulukutla, Jean W Hsu, Ruchi Gaba, Kurt M Bohren, Anu Guthikonda, Dinakar Iyer, Nadim J Ajami, Joseph F Petrosino, Christiane S Hampe, Nalini Ram, Farook Jahoor, Ashok Balasubramanyam
Background: A-β + ketosis-prone diabetes (KPD) is a subset of type 2 diabetes in which patients have severe but reversible β cell dysfunction of unknown etiology. Plasma metabolomic analysis indicates that abnormal arginine metabolism may be involved. Objective: The objective of this study was to determine the relation between gut microbiome and arginine metabolism and the relation between arginine availability and β cell function in KPD patients compared with control participants...
February 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29483894/clinical-characteristics-of-wolfram-syndrome-in-chinese-population-and-a-novel-frameshift-mutation-in-wfs1
#19
Lian Duan, Qian Li, An-Li Tong, Jiang-Feng Mao, Miao Yu, Tao Yuan, Xiao-Feng Chai, Feng Gu
Objective: Wolfram syndrome (WS) is a rare, degenerative, and hereditary disorder characterized by ear diabetes mellitus (DM) and optic atrophy (OA). We aim to characterize clinical features in Chinese patients who had been poorly studied until now. Methods: We performed a retrospective review of patients with WS seen in the Peking Union Medical College Hospital from 2002 to 2017. Data including demographic data, clinical presentations, examination results, family history, and genetic analysis were described...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29483798/electrocardiographic-changes-in-children-with-diabetic-ketoacidosis-and-ketosis
#20
Deniz Aygün, Fatih Aygün, Kemal Nişli, Firdevs Baş, Agop Çıtak
Aim: We aimed to study electrocardiographic changes in children with diabetic ketoacidosis and ketosis and to evaluate the relation of the changes with serum electrolyte levels and ketosis. Material and Methods: This study was performed in Istanbul Medical Faculty, Pediatric Emergency and Intensive Care Department between May 2008 and May 2009. The electrocardiographic parameters and QT length of children with diabetic ketoacidosis and ketosis were evaluated at diagnosis and after the treatment...
December 2017: Türk Pediatri Arşivi
keyword
keyword
47544
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"