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Oral squamous cell

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https://www.readbyqxmd.com/read/28636114/set-i2pp2a-overexpression-induces-phenotypic-molecular-and-metabolic-alterations-in-an-oral-keratinocyte-cell-line
#1
Lays M Sobral, Ricardo D Coletta, Luciane C Alberici, Carlos Curti, Andréia Machado Leopoldino
The multifunctional SET/I2PP2A protein is known to be overexpressed in head and neck squamous cell carcinoma. However, SET has been reported to have apparently conflicting roles in promoting cancer cell survival under oxidative stress conditions and preventing invasion and metastasis, complicating efforts to understand the contribution of SET to carcinogenesis. In the present study, we overexpressed SET in a spontaneously immortalized oral keratinocyte cell line (NOK-SI SET) and demonstrated that SET up-regulation alone was sufficient to transform cells...
June 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28635994/oral-field-cancerization-history-and-future-perspectives
#2
A Gabusi, L Morandi, S Asioli, M P Foschini
Notwithstanding extended surgical approaches or adjuvant chemoradiotherapy, the development of multiple neoplastic lesions arising in the oral cavity after treatment still represents a critical clinical challenge in the management of patients with oral squamous cell carcinoma. Such clinical behavior of oral squamous cell carcinoma is nowadays better known as "field" cancerization effect as suggested by Slaughter, the author that for the first time tried to describe it in a scientific paper. Field cancerization is now widely accepted not only in head and neck oncology but also in other anatomical districts as well as in different types of epithelial neoplasia...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28633362/human-papillomavirus-related-oropharyngeal-cancer
#3
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía
High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28632936/peritumoral-cuffing-by-t-cell-tumor-infiltrating-lymphocytes-distinguishes-hpv-related-oropharyngeal-squamous-cell-carcinoma-from-oral-cavity-squamous-cell-carcinoma
#4
Kate Poropatich, David Hernandez, Joel Fontanarosa, Koshonna Brown, Gayle Woloschak, Ajit Paintal, Kirtee Raparia, Sandeep Samant
BACKGROUND: It is unclear why human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) has improved clinical behavior compared to HPV-negative HNSCC. We sought to better characterize the immune microenvironment of tongue cancers by examining the CD3 and CD8 TIL pattern in HPV-positive and -negative tumors. METHODS: Histologic sections from 40 oral tongue and oropharyngeal cases were analyzed (n= 21 HPV DNA-positive, n= 19 HPV DNA-negative)...
June 20, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28632724/oral-squamous-cell-carcinoma-patients-can-be-differentiated-from-healthy-individuals-with-label-free-serum-proteomics
#5
Mayank Saraswat, Antti Mäkitie, Rahul Agarwal, Sakari Joenväärä, Suvi Renkonen
BACKGROUND: No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC. METHODS: Serum samples from patients with OSCC treated at the Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital (Finland) were collected...
June 20, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28631562/cancer-stem-cell-markers-in-patterning-differentiation-and-in-prognosis-of-oral-squamous-cell-carcinoma
#6
Simple Mohanta, Gangotri Siddappa, Sindhu Govindan Valiyaveedan, Ravindra Dodda Thimmasandra Ramanjanappa, Debashish Das, Ramanan Pandian, Samanta Sekhar Khora, Moni Abraham Kuriakose, Amritha Suresh
Differentiation is a major histological parameter determining tumor aggressiveness and prognosis of the patient; cancer stem cells with their slow dividing and undifferentiated nature might be one of the factors determining the same. This study aims to correlate cancer stem cell markers (CD44 and CD147) with tumor differentiation and evaluate their subsequent effect on prognosis. Immunohistochemical analysis in treatment naïve oral cancer patients (n = 53) indicated that the expression of CD147 was associated with poorly differentiated squamous cell carcinoma and moderately differentiated squamous cell carcinoma (p < 0...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28631549/comparison-of-histological-and-proliferation-features-of-canine-oral-squamous-cell-carcinoma-based-on-intraoral-location-36-cases
#7
Lisa A Mestrinho, Hugo Pissarra, Sandra Carvalho, Maria C Peleteiro, Jerzy Gawor, Maria M R E Niza
Grade and labeling indices for immunohistochemical tumor proliferation markers Ki-67 and proliferating cell nuclear antigen (PCNA) were evaluated in 36 cases of canine oral squamous cell carcinoma (OSCC) based upon intraoral location. Grade was significantly associated with location ( P = .035). Grade II tumors were most frequently diagnosed. Grade I tumors were identified in the gingiva and the buccal mucosa, and grade III tumors were seen in the gingiva and the tonsillar region. Animals with tumors arising from the tonsils and of the tongue tended to be older ( P = ...
June 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28628354/soft-tissue-enhancement-and-implant-placement-following-partial-mandibulectomy-due-to-squamous-cell-carcinoma
#8
Fabio Bernardello, Giampietro Bertasi, Ralph Mackey Powers, Sergio Spinato, Andrea Viaggi, Jimmie Bullock, Pietro Felice
Many dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Where problems will arise is from the lack of adequate bone quality and quantity.1,2 Soft tissue form and maintenance is also a consideration to evaluate.3 Primary reconstructive techniques following segmental mandibulectomy is evolving and improves quality of life...
June 19, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/28627802/the-length-of-patient-and-primary-care-time-interval-in-the-pathways-to-treatment-in-symptomatic-oral-cancer-a-quantitative-systematic-review
#9
P Varela-Centelles, J Seoane, J L Lopez-Cedrun, J Fernandez-Sanroman, J M García-Martin, B Takkouche, P Alvarez-Novoa, J M Seoane-Romero
BACKGROUND: Only a 5% improvement in overall survival to oral cancer has been achieved in the last 20 years. Almost half of all oral carcinomas are diagnosed at advanced stages essentially due to delay in the diagnosis. Objective of the review: to examine the relative length of the patient and primary care intervals in symptomatic oral cancer. TYPE OF REVIEW: Quantitative systematic review. SEARCH STRATEGY: ((oral cancer OR oral squamous cell carcinoma OR oropharyngeal cancer) AND (time interval OR diagnostic delay))...
June 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28627030/mir-375-slc7a11-axis-regulates-oral-squamous-cell-carcinoma-proliferation-and-invasion
#10
Yadong Wu, Xiangjie Sun, Bin Song, Xiaoling Qiu, Jianjiang Zhao
We aimed to detect the functions of miR-375/SLC7A11 axis on oral squamous cell carcinoma (OSCC) cell proliferation and invasion. Expression levels of miR-375 and SLC7A11 in OSCC tissues and cells were measured with RT-qPCR and western blot. Targeting site was predicted by TargetScan and confirmed by dual luciferase reporting assay. By way of manipulating the expression level of miR-375 and SLC7A11 in CAL-27 and Tca8113 cell lines, the cell biological abilities were evaluated. MTT, colony formation, Transwell, wound healing assays and flow cytometry were used to detect OSCC cell viability, proliferation, invasion, migration and apoptosis, respectively...
June 19, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28626969/different-patterns-of-expression-of-cell-cycle-control-and-local-invasion-related-proteins-in-oral-squamous-cell-carcinoma-affecting-young-patients
#11
Marisol Miranda Galvis, Alan Roger Santos-Silva, Juscelino Freitas Jardim, Felipe Paiva Fonseca, Marcio A Lopes, Oslei P Almeida, Clóvis A Lópes Pinto, Estela Kaminagakura, Iris Sawazaki-Calone, Paul M Speight, Luiz Paulo Kowalski
Oral squamous cell carcinoma (OSCC) predominantly affects males in the fifth decade of life; nevertheless, an increased incidence in young patients has been reported worldwide and the clinical and behavioral characteristics of tumors in this group are controversial and the literature shows divergent results PURPOSE: To investigate the clinicopathological features and prognostic significance of the immunoexpression of cell cycle and local invasion proteins in OSCC affecting young patients (≤ 40 years old) METHODS: A tissue microarray was performed with 132 OSCC samples (61 cases of young patients vs...
June 19, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28626726/cancer-stem-cells-in-oral-cavity-squamous-cell-carcinoma-a-review
#12
REVIEW
Ranui Baillie, Swee T Tan, Tinte Itinteang
Cancer stem cells (CSCs) have been identified in oral cavity squamous cell carcinoma (OCSCC). CSCs possess the ability for perpetual self-renewal and proliferation, producing downstream progenitor cells and cancer cells that drive tumor growth. Studies of many cancer types including OCSCC have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This is compounded further by the presence of multiple CSC subtypes within OCSCC, making investigation reliant on the use of multiple markers...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28626254/the-maximum-standardized-uptake-value-increment-calculated-by-dual-time-point-18-f-fluorodeoxyglucose-positron-emission-tomography-predicts-survival-in-patients-with-oral-tongue-squamous-cell-carcinoma
#13
Natsuki Yonezawa, Tsutomu Minamikawa, Kazuhiro Kitajima, Yusuke Takahashi, Ryohei Sasaki, Ken-Ichi Nibu, Takahide Komori
The aim of this study was to investigate the prognostic value of dual-time-point (DTP) (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) imaging in primary oral tongue squamous cell carcinoma (OTSCC). The study included 52 patients who underwent preoperative (18)F-FDG PET scans at two time points, namely 1 h and 2 h after injection. The following PET parameters were calculated: maximum standardized uptake value (SUVmax) for both time points (SUV early, SUV delayed); retention index (RI); and SUVmax increment (ΔSUVmax)...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28624699/toll-like-receptor-2-rs4696480-polymorphism-and-risk-of-oral-cancer-and-oral-potentially-malignant-disorder
#14
Camila de Barros Gallo, Xabier Marichalar-Mendia, Amaia Setien-Olarra, Amelia Acha-Sagredo, Naiara Garcia Bediaga, Maria Luisa Gainza-Cirauqui, Norberto Nobuo Sugaya, Jose Manuel Aguirre-Urizar
OBJECTIVES: The aim of this study was to identify the possible association between TLR polymorphisms and an increased risk of developing head and neck cancer, including oral (OSCC) and laryngeal squamous cell carcinoma (LSCC), and oral potentially malignant disorders, such as oral lichenoid disease (OLD), including oral lichen planus (OLP) and oral lichenoid lesions (OLL). DESIGN: This case-control study included 40 OSCC, 35 LSCC, 175 OLD (129 OLP and 46 OLL) patients and 89 healthy controls, all of them from the Basque Country, Spain...
June 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28624429/squamous-cell-carcinoma-of-the-retromolar-trigone-treatment-outcomes
#15
Hideaki Nishi, Takeshi Shinozaki, Toshifumi Tomioka, Takashi Maruo, Ryuichi Hayashi
OBJECTIVE: Squamous cell carcinoma (SCC) of the retromolar trigone is uncommon, accounting for 1.4% of all oral cancer cases in Japan. Few studies have examined the optimal treatment for this cancer. The aim of this study was to evaluate the outcome of treatment for primary SCC of the retromolar area. METHODS: We retrospectively analyzed the outcome and prognosis of 45 patients (38 men, 7 women) with SCC of the retromolar trigone who underwent treatment in our department between July 1992 and March 2011...
June 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28623128/targeting-pi3k-akt-mtor-by-ly3023414-inhibits-human-skin-squamous-cell-carcinoma-cell-growth-in-vitro-and-in-vivo
#16
Ying Zou, Minggai Ge, Xuemin Wang
Abnormal activation of PI3K-AKT-mTOR signaling is detected in human skin squamous cell carcinoma (SCC). LY3023414 is a novel, potent, and orally bio-available PI3K-AKT-mTOR inhibitor. Its activity against human skin SCC cells was tested. We demonstrated that LY3023414 was cytotoxic when added to established (A431 line) and primary (patient-derived) human skin SCC cells. LY3023414 induced G0/1-S arrest and inhibited proliferation of skin SCC cells. Moreover, LY3023414 induced activation of caspase-3/-9 and apoptosis in skin SCC cells...
June 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28622887/genetic-etiology-of-oral-cancer
#17
REVIEW
Johar Ali, Bibi Sabiha, Hanif Ullah Jan, Syed Adnan Haider, Abid Ali Khan, Saima S Ali
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It accounts for 2.5% of all new cancer cases and 1.9% of all cancer deaths annually. More than 90% of oral cancers (occurring in the mouth, lip, and tongue) are oral squamous cell carcinoma. The incidence rate of oral cancer varies widely throughout the world, with an evident prevalence in South Asian countries. This high incidence occurs in correlation with oral cancer-associated behaviors such as alcohol, tobacco use...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28618939/rapamycin-enhances-the-anti-angiogenesis-and-anti-proliferation-ability-of-ym155-in-oral-squamous-cell-carcinoma
#18
Kong-Liang Li, Yu-Fan Wang, Jia-Ruo Qin, Feng Wang, Yong-Tao Yang, Li-Wu Zheng, Ming-Hua Li, Jie Kong, Wei Zhang, Hong-Yu Yang
YM155, a small molecule inhibitor of survivin, has been studied in many tumors. It has been shown that YM155 inhibited oral squamous cell carcinoma through promoting apoptosis and autophagy and inhibiting proliferation. It was found that YM155 also inhibited the oral squamous cell carcinoma-mediated angiogenesis through the inactivation of the mammalian target of rapamycin pathway. Rapamycin, a mammalian target of rapamycin inhibitor, played an important role in the proliferation and angiogenesis of oral squamous cell carcinoma cell lines...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28618017/curcumin-and-metformin-mediated-chemoprevention-of-oral-cancer-is-associated-with-inhibition-of-cancer-stem-cells
#19
Gangotri Siddappa, Safeena Kulsum, Doddathimmasandra Ramanjanappa Ravindra, Vinay V Kumar, Nalini Raju, Nisheena Raghavan, Holalugunda Vittalamurthy Sudheendra, Anupam Sharma, Sumsum P Sunny, Tina Jacob, Binu T Kuruvilla, Merina Benny, Benny Antony, Mukund Seshadri, Padma Lakshminarayan, Wesley Hicks, Amritha Suresh, Moni A Kuriakose
Effective chemoprevention is critical for improving outcomes of oral cancer. As single agents, curcumin and metformin, are reported to exhibit chemopreventive properties, in vitro as well as in patients with oral cancer. In this study, the chemopreventive efficacy of this drug combination was tested in a 4NQO (4-nitro-quinoline-oxide) induced, mice oral carcinogenesis model. Molecular analysis revealed a cancer stem cell (CSC)-driven, oral carcinogenic progression in this model, wherein a progressive increase in the expression of CSC-specific markers (CD44 and CD133) was observed from 8th to 25th week, at transcript (40 to 100 fold) and protein levels (p≤0...
June 15, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28615224/risk-of-second-malignancies-in-solid-organ-transplant-recipients-who-develop-keratinocyte%C3%A2-cancers
#20
Rachel Zamoiski, Elizabeth L Yanik, Todd M Gibson, Elizabeth K Cahoon, Margaret M Madeleine, Charles F Lynch, Sally Gustafson, Marc T Goodman, Melissa Skeans, Ajay Israni, Eric A Engels, Lindsay M Morton
Solid organ transplant recipients have increased risk for developing keratinocyte cancers (KC), including cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), in part as a result of immunosuppressive medications administered to prevent graft rejection. In the general population, KC are associated with increased risks of subsequent malignancy, however, the risk in organ transplant populations has not been evaluated. We addressed this question by linking the U.S. Scientific Registry of Transplant Recipients, which includes data on KC occurrence, with 15 state cancer registries...
June 14, 2017: Cancer Research
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