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https://www.readbyqxmd.com/read/29777637/thymol-inhibits-oral-squamous-cell-carcinoma-growth-via-mitochondria-mediated-apoptosis
#1
Jorge J De La Chapa, Prajjal Kanti Singha, Debbie R Lee, Cara B Gonzales
BACKGROUND: Thymol is a Transient Receptor Potential Ankyrin Subtype 1 channel, (TRPA1) agonist found in thyme and oregano. Thymol has antioxidant, anti-inflammatory, and antimicrobial properties; thus thymol is added to many commercially available products including Listerine mouthwash. Thymol is also cytotoxic to HL-60 (acute promyelotic leukemia) cells in vitro. Therefore, we evaluated the effects of thymol against oral squamous cell carcinoma (OSCC) and its anticancer mechanism-of-action...
May 19, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29775618/association-between-klotho-expression-and-malignancies-risk-and-progression-a-meta-analysis
#2
Song Mao, Xiaopeng Wang, Liangxia Wu, Dou Zang, Wenjing Shi
BACKGROUND: We assessed the association between tissue klotho protein expression and the risk and progression of malignancies. METHODS: We searched the electronic databases for the studies regarding the relationship between tissue klotho protein expression and risk/progression of malignancies through January 2018. We calculated the pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) to evaluate the impact of tissue klotho protein expression on malignancies...
May 15, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29775074/recent-changes-of-classification-for-squamous-intraepithelial-lesions-of-the-head-and-neck
#3
Kyung-Ja Cho, Joon Seon Song
CONTEXT: - Interpretation of atypical squamous lesions of the head and neck has always been a nettlesome task for pathologists. Moreover, many different grading systems for squamous intraepithelial lesions have been proposed in past decades. The recent World Health Organization 2017 classification presents 2 types of 2-tier systems for laryngeal and oral precursor lesions. OBJECTIVE: - To review the recent changes in classification and the clinical significance for squamous intraepithelial lesions of the head and neck...
May 18, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29774014/oral-microbiota-community-dynamics-associated-with-oral-squamous-cell-carcinoma-staging
#4
Chia-Yu Yang, Yuan-Ming Yeh, Hai-Ying Yu, Chia-Yin Chin, Chia-Wei Hsu, Hsuan Liu, Po-Jung Huang, Song-Nian Hu, Chun-Ta Liao, Kai-Ping Chang, Yu-Liang Chang
Oral squamous cell carcinoma (OSCC) is a highly aggressive cancer and the fourth leading malignancy among males in Taiwan. Some pathogenic bacteria are associated with periodontitis and oral cancer. However, the comprehensive profile of the oral microbiome during the cancer's progression from the early stage to the late stage is still unclear. We profiled the oral microbiota and identified bacteria biomarkers associated with OSCC. The microbiota of an oral rinse from 51 healthy individuals and 197 OSCC patients at different stages were investigated using 16S rRNA V3V4 amplicon sequencing, followed by bioinformatics and statistical analyses...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29772443/mir-92a-regulates-oral-squamous-cell-carcinoma-oscc-cell-growth-by-targeting-foxp1-expression
#5
Jun Guo, Ning Wen, Sefei Yang, Xiaohang Guan, Song Cang
Increasing evidence indicates that microRNAs dysregulation contributes to the development and progression of various human cancers, including oral squamous cell carcinoma (OSCC). However, little is known about the potential role of microRNA-92a (miR-92a) in OSCC. Thus, the aim of this study was to investigate the effects of miR-92a expression on OSCC cell growth, apoptosis and tumorigenesis. Real-time quantitative polymerase chain reaction was used to detect the expression level of miR-92a in primary tumor tissues and OSCC cell lines...
May 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#6
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29769506/evaluating-the-role-of-immunological-cells-tissue-eosinophils-and-mast-cells-in-progression-of-oral-squamous-cell-carcinoma
#7
S Saxena, A Singh, P Singh, K S Sundaragiri, B Sankhla, A Bhargava
Mast cells and eosinophils are increased in oral squamous cell carcinoma. The significance of such an association has been variably thought to be either a potential diagnostic tool for stromal invasion or as a prognostic indicator. The aim of the study was to study the mast cells and eosinophils between normal oral mucosa, leukoplakia and oral squamous cell carcinoma and to study the significance of mast cells in the progression of the lesion. A retrospective study was done on archival tissue received from January 2015 to December 2015, in the Department of Oral Pathology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769413/synergistic-anti-cancer-effects-of-nanocarrier-loaded-with-berberine-and-mirna-122
#8
Lei Li, Xiao Li, Xin Huang, Weilai Jiang, Letian Liu, Chunning Hou, Yanqing Yang, Lei Zhang, Xiaodan Zhang, Longwei Ye, Jie Yuan, Guolin Li, Haiming Sun, Limin Mao
We introduced polyethyleneimine-cholesterol (PC) as a nanocarrier incorporating berberine (BER) and miRNA122 (miR-122) for the treatment of oral squamous cell carcinoma. BER was stabilized by incorporating PC to form ber -PC. Ber -PC was further electrostatically complexed with miR-122 to yield mr-ber- PC for the co-delivery of BER and miR-122. mr-ber- PC treatment dramatically decreased the level of invasion and migration of oral squamous cell carcinoma cells compared with single drug treatments. This study suggested that PC could be a multifunctional nanocarrier for the co-delivery of anti-cancer drug BER and miR-122 to significantly increase the anti-cancer therapeutic effects...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29768689/hsp-enriched-properties-of-extracellular-vesicles-involve-survival-of-metastatic-oral-cancer-cells
#9
Kisho Ono, Takanori Eguchi, Chiharu Sogawa, Stuart K Calderwood, Junya Futagawa, Tomonari Kasai, Masaharu Seno, Kuniaki Okamoto, Akira Sasaki, Ken-Ichi Kozaki
Cancer cells often secrete extracellular vesicles (EVs) that carry heat shock proteins (HSPs) with roles in tumor progression. Oral squamous cell carcinoma (OSCC) belongs to head and neck cancers (HNC) whose lymph-node-metastases often lead to poor prognosis. We have examined the EV proteome of OSCC cells and found abundant secretion of HSP90-enriched EVs in lymph-node-metastatic OSCC cells. Double knockdown of HSP90α and HSP90β, using small interfering RNA significantly reduced the survival of the metastatic OSCC cells, although single knockdown of each HSP90 was ineffective...
May 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29768280/phase-i-ii-trial-of-chemotherapy-with-docetaxel-cisplatin-and-s-1-for-unresectable-advanced-squamous-cell-carcinoma-of-the-esophagus
#10
Toshiyasu Ojima, Masaki Nakamura, Mikihito Nakamori, Masahiro Katsuda, Keiji Hayata, Shimpei Maruoka, Toshio Shimokawa, Hiroki Yamaue
Our previous trial with a docetaxel, cisplatin, and 5-fluorouracil (DCF) regimen showed high response rates in metastatic squamous cell carcinoma of the esophagus (SCCE). The observed increased toxicity of the DCF regimen, however, was clinically harmful. S-1, an oral anticancer drug, has been approved as a combination therapy for SCCE, and alternate-day regimen with S-1 has shown lower levels of toxicity. This prospective single-center phase I/II trial examines the efficacy and toxicity of a combination of docetaxel, cisplatin, and an alternate-day regimen of S-1 (modified DCS) for patients with metastatic SCCE...
May 16, 2018: Oncology
https://www.readbyqxmd.com/read/29767262/transcutaneous-carbon-dioxide-enhances-the-antitumor-effect-of-radiotherapy-on-oral-squamous-cell-carcinoma
#11
Eiji Iwata, Takumi Hasegawa, Takeshi Ueha, Daisuke Takeda, Izumi Saito, Teruya Kawamoto, Toshihiro Akisue, Yoshitada Sakai, Ryohei Sasaki, Ryosuke Kuroda, Takahide Komori
Radiotherapy (RT) is one of the main treatment modalities for oral squamous cell carcinoma (OSCC), however, radioresistance is a major impediment to its clinical success and poses as a concern that needs to be addressed. Tumor hypoxia is known to be significantly associated with radioresistance in various malignancies, hence, resolving the hypoxic state of a tumor may improve the antitumor effect of RT on OSCC. We have previously revealed that transcutaneous CO2 induced mitochondrial apoptosis and suppressed tumor growth in OSCC by resolving hypoxia...
May 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29764807/predicting-the-presence-of-oral-squamous-cell-carcinoma-using-commonly-dysregulated-microrna-in-oral-swirls
#12
Tami Yap, Kendrick Koo, Lesley Cheng, Laura J Vella, Andrew F Hill, Eric C Reynolds, Alf L Nastri, Nicola Cirillo, Christine A Seers, Michael McCullough
Oral swirls are a noninvasive, rapidly collected source of salivary microRNA potentially useful in the early detection of disease states, particularly oral squamous cell carcinoma (OSCC). The aim of this study was to predict the presence of oral squamous cell carcinoma using a panel of OSCC-related dysregulated microRNA found in oral swirls, identified jointly in data from formalin-fixed paraffin embedded (FFPE) and fresh frozen specimens. Next generation sequencing (NGS) was used to determine microRNA fold changes in FFPE OSCC specimens relative to histologically normal epithelium...
May 15, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29763905/scca-tsgf-and-the-long-non-coding-rna-ac007271-3-are-effective-biomarkers-for-diagnosing-oral-squamous-cell-carcinoma
#13
Tingru Shao, Jiaxin Huang, Zenan Zheng, Qingqing Wu, Tiancai Liu, Xiaozhi Lv
BACKGROUND/AIMS: Oral squamous cell carcinoma (OSCC) is one of the most lethal malignancies worldwide and the most common type of oral cancer, characterized by invasive growth, frequent regional metastases, high recurrence, and poor prognosis. In the current study, we investigated the use of long non-coding RNAs (lncRNAs), tumor-specific growth factor (TSGF), and squamous cell carcinoma antigen (SCCA) as potential biomarkers for OSCC screening. METHODS: LncRNA expression was measured by microarray analysis in three sets of OSCC and paired normal mucosal tissues...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761594/extracellular-interleukin-17f-has-a-protective-effect-in-oral-tongue-squamous-cell-carcinoma
#14
Rabeia Almahmoudi, Abdelhakim Salem, Meri Sieviläinen, Elias Sundquist, Alhadi Almangush, Sanna Toppila-Salmi, Timo Paavonen, Tuula Salo, Ahmed Al-Samadi
BACKGROUND: Oral tongue squamous cell carcinoma (SCC) is characterized by early metastasis and poor prognosis. Interleukin-17F (IL-17F) plays a protective role in many tumors. However, IL-17F expression in oral tongue SCC tissue has not been investigated. METHODS: Immunostaining of 83 oral tongue SCC specimens and blinded-scoring were used to map IL-17F expression, location, and distribution. Survival curves were constructed according to Kaplan-Meier method. The Cox proportional hazard model was applied for univariate and multivariate survival analyses...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761586/preoperative-predictors-of-occult-nodal-disease-in-ct1n0-oral-cavity-squamous-cell-carcinoma-review-of-2623-cases
#15
Kevin Y Zhan, Patrick F Morgan, David M Neskey, Joanne J Kim, Andrew T Huang, Elizabeth Garrett-Mayer, Terry A Day
BACKGROUND: Nodal disease predicts survival in oral cavity squamous cell carcinoma (SCC). Currently, no large studies on predictors of occult nodal disease in cT1N0 oral cavity SCC exist. METHODS: The National Cancer Database (NCDB) review for cT1N0 oral cavity SCC with surgical resection and elective neck dissection (END). RESULTS: The number of patients found with occult nodal disease was 2623 (15.1%). In multivariable regression, female sex and tumor differentiation predict occult nodal disease...
May 14, 2018: Head & Neck
https://www.readbyqxmd.com/read/29761306/low-expression-of-cd40l-in-tumor-free-lymph-node-of-oral-cavity-cancer-related-with-poor-prognosis
#16
Yoon Chan Rah, Jae-Cheul Ahn, Eun-Hui Jeon, Hyojin Kim, Jin Ho Paik, Woo-Jin Jeong, Soon-Young Kwon, Soon-Hyun Ahn
BACKGROUND: Recently, the genetic alterations associated with tumor progression and impaired host immunity against transformed cells draw increased attention. Here, we characterized the differential gene expression patterns and protein expression in tumor-free lymph node from recurrent and non-recurrent tumors to identify independent prognostic markers for oral squamous cell carcinoma (OSCC). METHODS: A cDNA microarray analysis was performed to identify the differentially expressed genes in regional tumor-free lymph nodes from OSCC patients with and without recurrence...
May 14, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29758011/invasion-related-factors-as-potential-diagnostic-and-therapeutic-targets-in-oral-squamous-cell-carcinoma-a-review
#17
REVIEW
Samadarani B S M Siriwardena, Takaaki Tsunematsu, Guangying Qi, Naozumi Ishimaru, Yasusei Kudo
It is well recognized that the presence of cervical lymph node metastasis is the most important prognostic factor in oral squamous cell carcinoma (OSCC). In solid epithelial cancer, the first step during the process of metastasis is the invasion of cancer cells into the underlying stroma, breaching the basement membrane (BM)-the natural barrier between epithelium and the underlying extracellular matrix (ECM). The ability to invade and metastasize is a key hallmark of cancer progression, and the most complicated and least understood...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29757457/the-role-of-adjuvant-treatment-in-early-stage-oral-cavity-squamous-cell-carcinoma-an-international-collaborative-study
#18
Eran Fridman, Shorook Na'ara, Jaiprakash Agarwal, Moran Amit, Gideon Bachar, Andrea Bolzoni Villaret, Jose Brandao, Claudio R Cernea, Pankaj Chaturvedi, Jonathan Clark, Ardalan Ebrahimi, Dan M Fliss, Sashikanth Jonnalagadda, Hugo F Kohler, Luiz P Kowalski, Matthias Kreppel, Chun-Ta Liao, Snehal G Patel, Raj P Patel, K Thomas Robbins, Jatin P Shah, Thomas Shpitzer, Tzu-Chen Yen, Joachim E Zöller, Ziv Gil
BACKGROUND: Up to half of patients with oral cavity squamous cell carcinoma (OCSCC) have stage I to II disease. When adequate resection is attained, no further treatment is needed; however, re-resection or radiotherapy may be indicated for patients with positive or close margins. This multicenter study evaluated the outcomes and role of adjuvant treatment in patients with stage I to II OCSCC. METHODS: Overall survival (OS), disease-specific survival, local-free survival, and disease-free survival rates were calculated with Kaplan-Meier analysis...
May 14, 2018: Cancer
https://www.readbyqxmd.com/read/29756979/prevention-of-oral-mucositis-secondary-to-antineoplastic-treatments-in-head-and-neck-cancer-by-supplementation-with-oral-glutamine
#19
Jerónimo Pachón Ibáñez, José Luis Pereira Cunill, Guiovana Fernanda Osorio Gómez, Jose Antonio Irles Rocamora, Pilar Serrano Aguayo, Begoña Quintana Ángel, José Fuentes Pradera, Manuel Chaves Conde, María José Ortiz Gordillo, Pedro Pablo García Luna
OBJECTIVES: to evaluate the efficacy of glutamine in the prevention of the incidence of oral mucositis secondary to cancer therapies in patients with head and neck cancer (HNC). Secondary objectives were to know the incidence of odynophagia, interruptions of treatment and the requirements of analgesia and nasogastric tube. MATERIAL AND METHODS: prospective cohort study of patients with squamous cell carcinoma of HNC treated with radiotherapy ± concomitant chemotherapy...
February 27, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29756608/nerve-and-vein-preserving-neck-dissections-for-oral-cancers-a-prospective-evaluation-of-spinal-accessory-nerve-function-and-internal-jugular-vein-patency-following-treatment
#20
G R Kumar Reddy, N Hulikal, A Y Lakshmi, B Vengamma
Nerve and vein preserving modification of the radical neck dissection is commonly used in the management of oral squamous cell cancers. There is limited literature addressing nerve function and vein patency following treatment. We prospectively analysed 65 patients with nerve conduction study using surface electromyography at baseline, 1 month and 6 months post-surgery and colour Doppler of the internal jugular vein at baseline and 1 month post-surgery. We also studied functional outcomes of nerve sparing with arm abduction test and Neck Dissection Quality of Life questionnaire...
February 2018: Acta Otorhinolaryngologica Italica
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