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https://www.readbyqxmd.com/read/28938795/lipid-lowering-nutraceuticals-in-clinical-practice-position-paper-from-an-international-lipid-expert-panel
#1
Arrigo F G Cicero, Alessandro Colletti, Gani Bajraktari, Olivier Descamps, Dragan M Djuric, Marat Ezhov, Zlatko Fras, Niki Katsiki, Michel Langlois, Gustavs Latkovskis, Demosthenes B Panagiotakos, Gyorgy Paragh, Dimitri P Mikhailidis, Olena Mitchenko, Bernhard Paulweber, Daniel Pella, Christos Pitsavos, Željko Reiner, Kausik K Ray, Manfredi Rizzo, Amirhossein Sahebkar, Maria-Corina Serban, Laurence S Sperling, Peter P Toth, Dragos Vinereanu, Michal Vrablík, Nathan D Wong, Maciej Banach
In recent years, there has been growing interest in the possible use of nutraceuticals to improve and optimize dyslipidemia control and therapy. Based on the data from available studies, nutraceuticals might help patients obtain theraputic lipid goals and reduce cardiovascular residual risk. Some nutraceuticals have essential lipid-lowering properties confirmed in studies; some might also have possible positive effects on nonlipid cardiovascular risk factors and have been shown to improve early markers of vascular health such as endothelial function and pulse wave velocity...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938495/polyphenol-enriched-fractions-of-cyclopia-intermedia-selectively-affect-lipogenesis-and-lipolysis-in-3t3-l1-adipocytes
#2
Babalwa U Jack, Christiaan J Malherbe, Elize L Willenburg, Dalene de Beer, Barbara Huisamen, Elizabeth Joubert, Christo J F Muller, Johan Louw, Carmen Pheiffer
Cyclopia species are increasingly investigated as sources of phenolic compounds with potential as therapeutic agents. Recently, we demonstrated that a crude polyphenol-enriched organic fraction (CPEF) of Cyclopia intermedia, currently forming the bulk of commercial production, decreased lipid content in 3T3-L1 adipocytes and inhibited body weight gain in obese db/db mice. The aim of the present study was to determine whether a more effective product and/or one with higher specificity could be obtained by fractionation of the CPEF by purposely increasing xanthone and benzophenone levels...
September 22, 2017: Planta Medica
https://www.readbyqxmd.com/read/28933306/diet-bioactive-compounds-implications-for-oxidative-stress-and-inflammation-in-the-vascular-system
#3
Morena Gabriele, Laura Pucci
BACKGROUND AND OBJECTIVE: Increasing evidence has demonstrated that dietary products and their active components are independently or jointly responsible for the apparent reduction of the cardiovascular diseases (CVDs) risk. DISCUSSION: Nowadays, there is a growing attention in the use of nutraceuticals as a new approach for the prevention and management of many diseases, as well as for controlling rising of chronic illnesses with minimal side effects. Food-derived peptides, as well as peptide-rich protein hydrolysates, represent new and valuable tools for the prevention of metabolic and cardiovascular diseases, acting as modulators of oxidative stress, inflammation, and overactivity of the renin-angiotensin system (RAS)...
September 21, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28933290/nutraceuticals-and-repurposed-drugs-of-phytochemical-origin-in-prevention-and-interception-of-chronic-degenerative-disease-and-cancer
#4
Adriana Albini, Barbara Bassani, Denisa Baci, Katiuscia Dallaglio, Matteo Gallazzi, Paola Corradino, Antonino Bruno, Douglas M Noonan
Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For many of these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy, thus the validation of novel (chemo)preventive and interceptive approaches, of new or repurposed agents, alone or in combination with registered drugs, are urgently required. Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, non-steroidal anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin) originally developed from phytochemical backbones, are multi-target agents showing anti-angiogenic and anti-anti-inflammatory proprieties...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28930617/genetic-manipulation-of-microalgae-for-the-production-of-bioproducts
#5
Patricia Vazquez-Villegas, Mario A Torres-Acosta, Sergio A Garcia-Echauri, Jose M Aguilar-Yanez, Marco Rito-Palomares, Federico Ruiz-Ruiz
Microalgae have been used during the past four decades in the Bio-industries for the production of high added value products and development of useful approaches with environmental applications. The fast growing rate, simple growth requirements and using sunlight as the major source of energy are the key factors for usage of algae. In the past 15 years, a considerable progress has been made regarding the use of microalgae for production of proteins, nutraceuticals, food supplements, molecular tags for diagnostics and fixation of greenhouse gases...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930188/cytotoxic-and-apoptotic-activities-of-prunus-spinosa-trigno-ecotype-extract-on-human-cancer-cells
#6
Stefania Meschini, Evelin Pellegrini, Maria Condello, Giovanni Occhionero, Sebastiano Delfine, Giancarlo Condello, Franco Mastrodonato
The aim of this work was to demonstrate that a natural compound, not-toxic to normal cells, has cytotoxic and sensitizing effects on carcinoma cells, with the final goal of combining it with chemotherapeutic drugs to reduce the overall dose. Prunus spinosa Trigno ecotype (PsT) drupe extract with a nutraceutical activator complex (NAC) made of amino acids, vitamins and mineral salt blends, has shown in vitro anticancer activity. The cytotoxic effect of (PsT + NAC)(®) has been evaluated on human cancer cells, with an initial screening with colorectal, uterine cervical, and bronchoalveolar cells, and a subsequent focus on colon carcinoma cells HCT116 and SW480...
September 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28928903/biomarkers-of-oxidative-stress-in-experimental-models-and-human-studies-with-nutraceuticals-measurement-interpretation-and-significance-2017
#7
EDITORIAL
Ilaria Peluso, Maura Palmery, Gregor Drummen
No abstract text is available yet for this article.
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28924492/the-essentials-of-a-global-index-for-cognitive-function
#8
Joseph Mathew Antony, Ian Weaver, Matthew Rueffer, Najla Guthrie, Malkanthi Evans
Cognition is comprised of the faculties: perception, creativity, intuition, and ratiocination. Optimal levels of cognition are needed for independent functioning and balanced living. With an aging population that continues to grow, dietary supplements that tilt the balance towards maintenance of cognition are being marketed for vulnerable populations facing these challenges. Randomized clinical trials provide the causal inference necessary to define the efficacy of emerging nutraceuticals. Cognition testing, in particular, requires a battery of tests that encompass all brain regions involved in cognition so as to provide endpoints necessary for product validation...
2017: Translational Neuroscience
https://www.readbyqxmd.com/read/28921388/immunomodulatory-potential-of-nanocurcumin-based-formulation
#9
Mahendra Kumar Trivedi, Sambhu Charan Mondal, Mayank Gangwar, Snehasis Jana
Vitamins, minerals, and nanocurcumin play a substantial role in various nutraceutical/pharmaceutical formulations that are widely used in therapeutics, cosmetics, and dietary supplements. The current study aimed to investigate the comparative in vitro immunomodulatory effect of a novel nanocurcumin-based formulation with curcumin in LPS-induced cytokine expression, NK cells' activity, and phagocytosis. The proinflammatory cytokines (TNF-α, IL-1β, and MIP-1α) and NK cells' activity were measured in cell supernatants using ELISA assay; however, phagocytosis activity was performed using colorimetric analysis...
September 18, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28920702/novel-technologies-applied-for-recovery-and-value-addition-of-high-value-compounds-from-plant-byproducts-a-review
#10
Xin-Li Ran, Min Zhang, Yuchuan Wang, Benu Adhikari
Plant byproducts of food processing industry line are undervalued yet important resource. These byproducts contain large percentage of high value functional substances such as antioxidants, pectin, polyphenols and so on. Recently, many research studies concentrated on innovative technologies that promise to overcome such issues as time consuming, inefficiency, and low yield, among others, which exist in most conventional techniques. Consequently, to achieve the recovery of nutraceuticals from high added-value by-products, it is necessary to have more knowledge of these novel technologies and more importantly explore the possibility of application of these latest technologies to the recovery downstream processing...
September 18, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28919860/a-multidirectional-perspective-for-novel-functional-products-in-vitro-pharmacological-activities-and-in-silico-studies-on-ononis-natrix-subsp-hispanica
#11
Serife Yerlikaya, Gokhan Zengin, Adriano Mollica, Mehmet C Baloglu, Yasemin Celik Altunoglu, Abdurrahman Aktumsek
The genus Ononis has important value as traditional drugs and foods. In the present work, we aimed to assess the chemical profiles and biological effects of Ononis natrix subsp. hispanica extracts (ethyl acetate, methanol, and water). For chemical profile, total and individual phenolic components were detected. For biological effects, antioxidant (DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, and metal chelating assays), enzyme inhibitory (against cholinesterase, tyrosinase, α-amylase and α-glucosidase), antimicrobial, DNA protection and cytotoxic abilities were tested...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28919858/safety-evaluation-of-sclerotium-from-a-medicinal-mushroom-lignosus-cameronensis-cultivar-preclinical-toxicology-studies
#12
Sook-Shien Lee, Nget-Hong Tan, Jayalakshmi Pailoor, Shin-Yee Fung
Twenty-eight days subacute toxicity studies performed in rats using sclerotial powder of Lignosus cameronensis cultivar was conducted to assess its safety for consumption prior to other scientific investigations on its medicinal benefits, nutraceutical or pharmaceutical application of the mushroom. The study was conducted at 250, 500, and 1000 mg/kg sclerotial powder of L. cameronensis cultivar (n = 5 for each respective dose, on both male and female groups) while control groups received only distilled water...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28918508/metabolic-engineering-of-schizosaccharomyces-pombe-to-produce-punicic-acid-a-conjugated-fatty-acid-with-nutraceutic-properties
#13
Martina Garaiova, Elzbieta Mietkiewska, Randall J Weselake, Roman Holic
Punicic acid (PuA) is a conjugated linolenic acid (C18:3Δ(9c,11t,13c)) with a wide range of nutraceutic effects with the potential to reduce the incidence of a number of health disorders including diabetes, obesity, and cancer. It is the main component of seed oil from Punica granatum and Trichosanthes kirilowii. Previously, production of relatively high levels of this unusual fatty acid in the seed oil of transgenic Arabidopsis thaliana plant was accomplished by the use of A. thaliana fad3/fae1 mutant high in linoleic acid (18:2∆(9c,12c)) and by co-expression of P...
September 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28914666/the-regulation-and-importance-of-monocyte-chemoattractant-protein-1
#14
Vanessa Bianconi, Amirhossein Sahebkar, Stephen L Atkin, Matteo Pirro
PURPOSE OF REVIEW: Monocyte chemoattractant protein (MCP)-1, a chemokine regulating monocyte chemotaxis and T-lymphocyte differentiation by binding to the CC chemokine receptor 2 (CCR2), plays a crucial role in the pathogenesis of inflammatory diseases, atherosclerosis and cancer. This review summarizes the current knowledge on the regulation and importance of the MCP-1/CCR2 axis, focusing on the therapeutic potential of its inhibition. RECENT FINDINGS: Differential modulation of MCP-1 and CCR2 lead to downstream activation pathways, pathogenetic to differing disease conditions characterized by dysregulated monocyte/macrophage tissue recruitment...
September 13, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28914449/insights-on-the-stilbenes-in-raboso-piave-grape-v-vinifera-l-as-a-consequence-of-post-harvest-vs-on-vine-dehydration
#15
Luca Brillante, Mirko De Rosso, Antonio Dalla Vedova, Itay Maoz, Riccardo Flamini, Diego Tomasi
BACKGROUND: Grape withering is a process used to produce reinforced wines and raisins. Dehydration is usually carried out post-harvest by keeping ripe grapes in special warehouses in controlled conditions of temperature, relative humidity (RH) and air-flow. Alternatively, grape clusters can be left on the vines after the canes have been pruned. In general, dehydration increases stilbenes in grape, but there are few studies on the effects of on-vine withering. The stilbene profiles of Raboso Piave grape during post-harvest and on-vine dehydration were studied here...
September 15, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28913359/nutraceutical-anti-inflammatory-and-immune-modulatory-effects-of-%C3%AE-glucan-isolated-from-yeast
#16
Umar Bacha, Muhammad Nasir, Sanaullah Iqbal, Aftab Ahmad Anjum
β-Glucan is a dietary fibre, found in many natural sources, and controls chronic metabolic diseases effectively. However, β-glucan from the yeast has rarely been investigated. Objectively, conditions were optimized to isolate β-glucan from the yeast (max. 66% yield); those optimized conditions included 1.0 M NaOH, pH 7.0, and 90°C. The purity and identity of the isolated β-glucan were characterized through FT-IR, SEM, DSC, and physicofunctional properties. The obtained results from DSC revealed highly stable β-glucan (m...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28912955/targeting-aspirin-resistance-with-nutraceuticals-a-possible-strategy-for-reducing-cardiovascular-morbidity-and-mortality
#17
EDITORIAL
James J DiNicolantonio, James H O'Keefe, Mark F McCarty
No abstract text is available yet for this article.
2017: Open Heart
https://www.readbyqxmd.com/read/28912082/mapk-signalling-pathway-in-cancers-olive-products-as-cancer-preventive-and-therapeutic-agents
#18
REVIEW
Ilaria Peluso, Nagendra Sastry Yarla, Roberto Ambra, Gianni Pastore, George Perry
The mitogen-activated protein kinases (MAPKs) are fundamental in inflammation and cancer control, through the crosstalk between the redox regulated nuclear factor E2-related factor 2 (Nrf2) and nuclear factor-kB (NFκB) gene expression. MAPKs regulate various cellular activities involved in cancer progression, including proliferation, apoptosis and immune escape and blockade of upstream kinases is a current therapeutic strategy. However, these therapies are associated with some adverse effects and with the paradoxical activation of the MAPKs pathway...
September 11, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28911528/macrophages-in-oxidative-stress-and-models-to-evaluate-the-antioxidant-function-of-dietary-natural-compounds
#19
REVIEW
Omir Adrian Castaneda, Sheng-Chi Lee, Chi-Tang Ho, Tzou-Chi Huang
Antioxidant testing of natural products has attracted increasing interest in recent years, mainly due to the fact that an antioxidant-rich diet might provide health benefits. Activated macrophages are a major source of reactive oxygen species, reactive nitrogen species, and peroxynitrite generated through the so-called respiratory burst. Constitutively released proinflammatory cytokine, especially tumor necrosis factor-α, triggers nuclear factor-κB, and activator protein-1 translocation leading to the over production of reactive oxygen species and reactive nitrogen species in macrophages...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910863/acceleration-of-aglycone-isoflavones-and-%C3%AE-aminobutyric-acid-production-from-doenjang-using-whole-cell-biocatalysis-accompanied-by-protease-treatment
#20
Yincong Li, Seockmo Ku, Myeong Soo Park, Zhipeng Li, Geun Eog Ji
Recently, soy bean isoflavone aglycones (i.e. daidzein and genistein) and γ-aminobutyric acid (GABA) have begun to receive considerable consumer attention due to their potential as nutraceuticals. To produce these ingredients, multiple microorganisms and their enzymes are commonly used for catalysis in the nutraceutical industry. In this work, we introduce a novel fermentation process that uses whole cell biocatalysis to accelerate γ-aminobutyric acid and isoflavone aglycones production in doenjang (traditional Korean soybean paste)...
September 15, 2017: Journal of Microbiology and Biotechnology
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