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https://www.readbyqxmd.com/read/27935709/physical-and-chemical-stability-of-curcumin-in-aqueous-solutions-and-emulsions-impact-of-ph-temperature-and-molecular-environment
#1
Mahesh Kharat, Zheyuan Du, Guodong Zhang, David Julian McClements
The utilization of curcumin as a nutraceutical in food and supplement products is often limited because of its low-water solubility, poor chemical stability, and low oral bioavailability. This study examined the impact of pH, storage temperature, and molecular environment on the physical and chemical stability of pure curcumin in aqueous solutions and in oil-in-water emulsions. Unlike naturally occurring curcuminoid mixtures (that contain curcumin, demethoxy-curcumin and bisdemethoxy-curcumin), pure curcumin was highly unstable to chemical degradation in alkaline aqueous solutions (pH ≥ 7...
December 9, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933987/influence-of-geographical-location-of-orchards-on-green-kiwifruit-bioactive-components
#2
Ivana Giangrieco, Simona Proietti, Stefano Moscatello, Lisa Tuppo, Alberto Battistelli, Francesco La Cara, Maurizio Tamburrini, Franco Famiani, Maria Antonietta Ciardiello
Italy is one of the world's major kiwifruit producers and exporters with orchards located in different areas from the north to the south of the peninsula. This study sought to investigate for the first time the possible influence of the geographical location of kiwifruit orchards on some fruit components, selected because of their involvement in beneficial or negative effects on human health. The fruits harvested in 16 Italian areas were analyzed, and the results obtained show that the observed variations of the relative amounts of total proteins, kiwellin, the major allergen actinidin, ascorbate, polyphenols, and superoxide dismutase (SOD)-like activity seem not to be related to the geographical location of the orchards...
December 7, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933876/inhibition-of-human-monoamine-oxidase-biological-and-molecular-modeling-studies-on-selected-natural-flavonoids
#3
Simone Carradori, Maria Concetta Gidaro, Anél Petzer, Giosuè Costa, Paolo Guglielmi, Paola Chimenti, Stefano Alcaro, Jacobus P Petzer
Naturally occurring flavonoids display a plethora of different biological activities, but emerging evidence suggests that this class of compounds may also act as antidepressant agents endowed with multiple mechanisms of action in the central nervous system, increasing central neurotransmission, limiting the reabsorption of bioamines by synaptosomes, and modulating the neuroendocrine and GABAA systems. Due to their presence in foods, food-derived products, and nutraceuticals, we established their role and structure-activity relationships as reversible and competitive human monoamine oxidase (MAO) inhibitors...
November 30, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27933660/are-nutraceuticals-the-modern-panacea-from-myth-to-science
#4
EDITORIAL
Pietro Minuz, Giampaolo Velo, Francesco Violi, Albert Ferro
No abstract text is available yet for this article.
January 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27931216/promising-features-of-moringa-oleifera-oil-recent-updates-and-perspectives
#5
REVIEW
Muhammad Nadeem, Muhammad Imran
Lipids are the concentrated source of energy, fat soluble vitamins, essential fatty acids, carriers of flavours and many bio-active compounds with important role in maintaining physiological functions of biological body. Moringa oleifera is native to Himalaya and widely grown in many Asian and African countries with seed oil content range from 35-40%. Moringa oleifera oil (MOO) has light yellow colour with mild nutty flavour and fatty acids composition suggests that MOO is highly suitable for both edible and non-edible applications...
December 8, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27930681/transcriptomic-changes-in-liver-of-young-bulls-caused-by-diets-low-in-mineral-and-protein-contents-and-supplemented-with-n-3-fatty-acids-and-conjugated-linoleic-acid
#6
Sara Pegolo, Alessio Cecchinato, Núria Mach, Massimiliano Babbucci, Marianna Pauletto, Luca Bargelloni, Stefano Schiavon, Giovanni Bittante
The aim of the present study was to identify transcriptional modifications and regulatory networks accounting for physiological and metabolic responses to specific nutrients in the liver of young Belgian Blue × Holstein bulls using RNA-sequencing. A larger trial has been carried out in which animals were fed with different diets: 1] a conventional diet; 2] a low-protein/low-mineral diet (low-impact diet) and 3] a diet enriched in n-3 fatty acids (FAs), conjugated linoleic acid (CLA) and vitamin E (nutraceutical diet)...
2016: PloS One
https://www.readbyqxmd.com/read/27929434/nutraceutical-supplements-in-the-management-and-prevention-of-osteoarthritis
#7
REVIEW
Paola Castrogiovanni, Francesca Maria Trovato, Carla Loreto, Houda Nsir, Marta Anna Szychlinska, Giuseppe Musumeci
Nutraceuticals are dietary compounds which have a role in the balance of anabolic and catabolic signals in joints. Their regulatory function on homeostasis of cartilage metabolism nutraceuticals is increasingly considered for the management and, above all, the prevention of osteoarthritis (OA). OA is a degenerative disease characterized by cartilage and synovium inflammation that can cause joint stiffness, swelling, pain, and loss of mobility. It is a multifactorial disease and, due to the great percentage of people suffering from it and the general increase in life expectancy, OA is considered as one of the most significant causes of disability in the world...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27929402/extraction-and-quantification-of-bioactive-tyrian-purple-precursors-a-comparative-and-validation-study-from-the-hypobranchial-gland-of-a-muricid-dicathais-orbita
#8
Roselyn Valles-Regino, Peter Mouatt, David Rudd, Lachlan H Yee, Kirsten Benkendorff
Muricidae are marine molluscs known for the production of Tyrian purple and bioactive precursor compounds. A validation study for the extraction and analysis of secondary metabolites found in the hypobranchial gland of the muricid Dicathais orbita is reported, using high performance liquid chromatography-mass spectrometry (HPLC-MS) with diode array detector (DAD). Quantification of the dominant secondary metabolites from D. orbita is described, followed by a comparison of solvent extraction procedures and stability studies...
December 5, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27924727/metabolomics-of-healthy-berry-fruits
#9
Gilda D Urso, Sonia Piacente, Cosimo Pizza, Paola Montoro
The consumption of berry-type fruits has become very popular in recent years because of their positive effects on human health. Berries are in fact widely known for their health-promoting benefits, including prevention of chronic disease, cardiovascular disease and cancer. Berries are a rich source of bioactive metabolites, such as vitamins, minerals, and phenolic compounds, mainly anthocyanins. Numerous in vitro and in vivo studies recognized the health effects of berries and their function as bioactive modulators of various cell functions associated with oxidative stress...
December 5, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27924120/hippophae-rhamnoides-n-glycoproteome-analysis-a-small-step-towards-sea-buckthorn-proteome-mining
#10
Yaiphabi Sougrakpam, Renu Deswal
Hippophae rhamnoides is a hardy shrub capable of growing under extreme environmental conditions namely, high salt, drought and cold. Its ability to grow under extreme conditions and its wide application in pharmaceutical and nutraceutical industry calls for its in-depth analysis. N-glycoproteome mining by con A affinity chromatography from seedling was attempted. The glycoproteome was resolved on first and second dimension gel electrophoresis. A total of 48 spots were detected and 10 non-redundant proteins were identified by MALDI-TOF/TOF...
October 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27920979/transcript-profiling-in-the-milk-of-dairy-ewes-fed-extruded-linseed
#11
Tommaso Giordani, Alberto Vangelisti, Giuseppe Conte, Andrea Serra, Lucia Natali, Annamaria Ranieri, Marcello Mele, Andrea Cavallini
The identification of genes regulating milk secretion by mammary glands is a key-step for exploiting changes in milk composition induced by different diet regimens. Linseed supplementation is a reliable feeding strategy to enhance polyunsaturated fatty acid content in milk fat from sheep, increasing milk quality and nutraceutical value. To investigate the molecular bases of diet induced differences in milk composition, we collected milk from dairy ewes at 90 day of lactation and after 3 weeks of diet supplementation with extruded linseed...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/27920817/pharmacological-characterization-of-liquiritigenin-a-chiral-flavonoid-in-licorice
#12
Samaa Alrushaid, Neal M Davies, Stephanie E Martinez, Casey L Sayre
Liquiritigenin is a chiral flavonoid present in plant based food, nutraceuticals, and traditional medicines. It is also an important ingredient present in licorice. The purpose of this study is to explore the pharmacological activity of racemic liquiritigenin utilizing several in vitro assays with relevant roles in colon cancer and diabetes. Where possible, the pure enantiomers were tested to identify the stereospecific contribution to the activity. In vitro antioxidant, anticancer, anti-inflammatory activities (cyclooxygenase inhibition), antidiabetic activities (alpha-amylase and alpha-glucosidase inhibition) as well as cytochrome P450 (CYP450) inhibitory activities were assessed...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27919272/enhanced-lipid-and-biomass-production-by-a-newly-isolated-and-identified-marine-microalga
#13
Mouna Dammak, Sandra Mareike Haase, Ramzi Miladi, Faten Ben Amor, Mohamed Barkallah, David Gosset, Chantal Pichon, Bernhard Huchzermeyer, Imen Fendri, Michel Denis, Slim Abdelkafi
BACKGROUND: The increasing demand for microalgae lipids as an alternative to fish has encouraged researchers to explore oleaginous microalgae for food uses. In this context, optimization of growth and lipid production by the marine oleaginous V2-strain-microalgae is of great interest as it contains large amounts of mono-unsaturated (MUFAs) and poly-unsaturated fatty acids (PUFAs). METHODS: In this study, the isolated V2 strain was identified based on 23S rRNA gene...
December 5, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27919262/erratum-to-clinical-evaluation-of-a-nutraceutical-diet-as-an-adjuvant-to-pharmacological-treatment-in-dogs-affected-by-keratoconjunctivitis-sicca
#14
Simona Destefanis, Daniela Giretto, Maria Cristina Muscolo, Alessandro Di Cerbo, Gianandrea Guidetti, Sergio Canello, Angela Giovazzino, Sara Centenaro, Giuseppe Terrazzano
No abstract text is available yet for this article.
December 5, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27916511/liqustri-lucidi-fructus-inhibits-hepatic-injury-and-functions-as-an-antioxidant-by-activation-of-amp-activated-protein-kinase-in-vivo-and-in-vitro
#15
Hye Lim Seo, Su Youn Baek, Eun Hye Lee, Ju-Hee Lee, Seul-Gi Lee, Kwang-Youn Kim, Mi Hee Jang, Min-Hui Park, Joung-Hee Kim, Keun-Jun Kim, Hyeong Sik Lee, Soon-Cheol Ahn, Jong Rok Lee, Sook Jahr Park, Sang Chan Kim, Young Woo Kim
Medicinal herbs are used to treat or prevent various diseases, and function to regulate protective mechanisms as nutraceuticals. Fructus Ligustri lucidi is the fruit of Ligustrum lucidum and has been used for its tonic effects on the liver. This study was designed to examine the effects of Fructus Ligustri lucidi water extract (FLL) against severe oxidative stress and mitochondrial impairment in vivo and in vitro and to elucidate its cellular mechanisms of action. Treatment of HepG2 cells with arachidonic acid (AA) + iron successfully induced oxidative stress and apoptosis, as indicated by depletion of glutathione, formation of ROS, increases in mitochondrial membrane permeability (MMP), and altered expression of apoptosis-related proteins, such as procaspase-3 and Bcl-xL...
December 1, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27916361/oral-omega-3-fatty-acids-promote-resolution-in-chemical-peritonitis
#16
Alexander C Chacon, Brett E Phillips, Miranda A Chacon, Deborah Brunke-Reese, Shannon L Kelleher, David I Soybel
BACKGROUND: Recent studies suggest that purified omega-3 fatty acids may attenuate acute inflammation and hasten the transition to healing. In this study, we tested the hypothesis that pretreatment with omega-3-rich fish oil (FO) would promote resolution of peritoneal inflammation through production of specific lipid mediators. METHODS: C57/BL6 mice were given a daily 200-μL oral gavage of saline (CTL) or FO (1.0-1.5 g/kg/d docosahexaenoic acid and 1.3-2.0 g/kg/d eicosapentaenoic acid) for 7 d before chemical peritonitis was induced with thioglycollate...
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27914878/hydroxytyrosol-modulates-the-levels-of-microrna-9-and-its-target-sirtuin-1-thereby-counteracting-oxidative-stress-induced-chondrocyte-death
#17
Stefania D'Adamo, Silvia Cetrullo, Serena Guidotti, Rosa Maria Borzì, Flavio Flamigni
OBJECTIVE: Nutraceutical compounds, such as hydroxytyrosol (HT), have been found to exert protective effects in osteoarthritis (OA) by affecting a variety of key molecular and cellular processes in chondrocytes. However, to our knowledge, no relationship has been reported between nutraceuticals and microRNA (miR) network in OA models. Here, we identified a miR that is implicated in hydroxytyrosol (HT)-mediated chondroprotection following oxidative stress condition by targeting sirtuin-1 (SIRT-1)...
November 30, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27914824/nutraceutical-inherent-of-spinacia-oleracea-linn-methanolic-leaf-extract-ameliorates-isoproterenol-induced-myocardial-necrosis-in-male-albino-wistar-rats-via-mitigating-inflammation
#18
Shivaranjani Vutharadhi, Umamaheswari Jolapuram, Lakshmi Devi Kodidhela
Cardiovascular diseases (CVDs) remain the principal cause of death in both developed and developing countries. The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis. Biochemical analysis of ISO injected rats showed significant alterations in the activities of homocysteine, paraoxonase, lecithin cholesterol acyltransferase, C-reactive protein, myeloperoxidase and caspase-3 which were further confirmed by the histopathological examination...
November 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27914331/fabrication-of-%C3%AE-carotene-nanoemulsion-based-delivery-systems-using-dual-channel-microfluidization-physical-and-chemical-stability
#19
Xiang Luo, Yanyan Zhou, Long Bai, Fuguo Liu, Yihui Deng, David Julian McClements
A considerable research effort is focused on developing effective delivery systems for hydrophobic nutraceuticals. β-carotene, a pro-vitamin A carotenoid, requires encapsulation to improve its water dispersibility and chemical stability in foods. In this study, β-carotene was encapsulated in oil-in-water nanoemulsions fabricated using high-pressure dual-channel microfluidization. Two types of natural emulsifier, quillaja saponins (Q-Naturale) and whey protein isolate (WPI), were capable of producing nanoemulsions (d32=0...
November 16, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27909993/impact-of-culture-conditions-on-the-chlorophyll-content-of-microalgae-for-biotechnological-applications
#20
REVIEW
Veronica da Silva Ferreira, Celso Sant'Anna
Chlorophyll is a commercially important natural green pigment responsible for the absorption of light energy and its conversion into chemical energy via photosynthesis in plants and algae. This bioactive compound is widely used in the food, cosmetic, and pharmaceutical industries. Chlorophyll has been consumed for health benefits as a nutraceutical agent with antioxidant, anti-inflammatory, antimutagenic, and antimicrobial properties. Microalgae are photosynthesizing microorganisms which can be extracted for several high-value bioproducts in the biotechnology industry...
January 2017: World Journal of Microbiology & Biotechnology
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