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https://www.readbyqxmd.com/read/29769493/immune-response-against-hepatitis-b-virus-after-pentavalent-vaccination-in-children
#1
R Karim, M S Rahman, M S Uddin
This study was done to know the real status of immune response to Hepatitis B vaccine among the pentavalent vaccinated children as per EPI schedule of Bangladesh. It was prospective observational study done in the EPI corner of Paediatric OPD of Dhaka National Medical College & Hospital (DNMCH), Dhaka from July 2015 to July 2016. Sixty (60) children ranging from 9 months to 2 years of age, who received pentavalent vaccination (Hepatitis B + DPT + Hib) according to EPI schedule, were included. The testing for anti-HBs titres were conducted in the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29769238/strength-in-numbers-opportunities-for-enhancing-the-development-of-effective-treatments-for-type-1-diabetes-the-trialnet-experience
#2
Carla J Greenbaum, Cate Speake, Jeffrey Krischer, Jane Buckner, Peter A Gottlieb, Desmond A Schatz, Kevan C Herold, Mark A Atkinson
The early to mid-1980s were an inflection point in the history of type 1 diabetes research. Two landmark events occurred: the initiation of immune-based interventions seeking to prevent type 1 diabetes and the presentation of an innovative model describing the disorder's natural history. Both formed the basis for hundreds of subsequent studies designed to achieve a dramatic therapeutic goal-a means to prevent and/or reverse type 1 diabetes. However, the need to screen large numbers of individuals and prospectively monitor them using immunologic and metabolic tests for extended periods of time suggested such efforts would require a large collaborative network...
May 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29765775/potential-impact-of-introducing-the-pneumococcal-conjugate-vaccine-into-national-immunisation-programmes-an-economic-epidemiological-analysis-using-data-from-india
#3
Itamar Megiddo, Eili Klein, Ramanan Laxminarayan
Pneumococcal pneumonia causes an estimated 105 000 child deaths in India annually. The planned introduction of the serotype-based pneumococcal conjugate vaccine (PCV) is expected to avert child deaths, but the high cost of PCV relative to current vaccines provided under the Universal Immunization Programme has been a concern. Cost-effectiveness studies from high-income countries are not readily comparable because of differences in the distribution of prevalent serotypes, population and health systems. We extended IndiaSim, our agent-based simulation model representative of the Indian population and health system, to model the dynamics of Streptococcus pneumoniae ...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29764447/efficacy-of-intra-articular-hypertonic-dextrose-prolotherapy-versus-normal-saline-for-knee-osteoarthritis-a-protocol-for-a-triple-blinded-randomized-controlled-trial
#4
Regina Wing Shan Sit, Ricky Wing Keung Wu, Kenneth Dean Reeves, David Rabago, Dicken Cheong Chun Chan, Benjamin Hon Kei Yip, Vincent Chi Ho Chung, Samuel Yeung Shan Wong
BACKGROUND: Knee Osteoarthritis (KOA) is a very common condition with prevalence rising with age. It is a major contributor to global disability and has a large socioeconomic burden worldwide. Conservative therapies have marginal effectiveness, and surgery is reserved for severe symptomatic KOA. Dextrose Prolotherapy (DPT) is an evidence-based injection-based therapy for chronic musculoskeletal conditions including KOA. The standard "whole joint" injection method includes intra-articular injection and multiple extra-articular injections at soft tissue bony attachments...
May 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29747655/microrna-21a-5p-overexpression-impacts-mediators-of-extracellular-matrix-formation-in-uterine-leiomyoma
#5
Eden R Cardozo, Rosemary Foster, Anatte E Karmon, Amy E Lee, Leah W Gatune, Bo R Rueda, Aaron K Styer
BACKGROUND: MicroRNAs (MiR) may promote fibroid development via altered expression of genes involved in cell proliferation and ECM formation, and evidence supports aberrant expression of MicroRNA (MiR) 21a-5p in fibroids. The purpose of this study was to investigate the functional significance of MiR 21a-5p overexpression in the pathobiology of leiomyomata (fibroids). METHODS: A basic science experimental design using immortalized fibroid and myometrial cell lines derived from patient-matched specimens was used...
May 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29730464/prevalence-of-calcifications-in-soft-tissues-visible-on-a-dental-pantomogram-a-retrospective-analysis
#6
Ana Ribeiro, Ross Keat, Sehrish Khalid, Senathirajah Ariyaratnam, Meeral Makwana, Maria do Pranto, Rui Albuquerque, Luis Monteiro
OBJECTIVES: To determine the frequency and spectrum of soft tissues calcifications identified on Dental Pantomograms (DPT) at a University Dental Clinic in the northern region of Portugal and to compare the data obtained with those published in the literature. METHODS: We conducted a 3-year descriptive analysis (2012-2014) of DPT calcifications within soft tissues at the University Clinic (CESPU), in Oporto, Portugal. Information on gender, age, location of the lesions and the radiographic diagnosis were analysed...
May 3, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29718586/measurement-of-rivaroxaban-concentrations-demonstrates-lack-of-clinical-utility-of-a-pt-dpt-and-aptt-test-in-estimating-levels
#7
I Thom, G Cameron, D Robertson, H G Watson
INTRODUCTION: Rivaroxaban concentrations were measured in 127 inpatient samples using an HPLC-MS/MS assay. METHODS: We compared this measurement with a calibrated anti-Xa assay and performed PT, aPTT and dilute PT tests to assess the value of clot-based assays in clinical decision-making. RESULTS: The correlation between the anti-Xa assay and the HPLC-MS/MS at therapeutic concentrations was strong (R2  = 0.98). The PT, RecombiPlasTin 2G, and aPTT, Actin FS, showed a linear dose-response but poor correlation (R2  = 0...
May 2, 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29708936/frequency-of-complications-during-preparation-of-corneal-lamellae-used-in-posterior-lamellar-keratoplasty-using-the-pneumodissection-technique-big-bubble
#8
Pavel Studeny, Magdalena Netukova, Martin Hlozanek, Jan Bednar, Katerina Jirsova, Deli Krizova
PURPOSE: To determine the frequency of formation of various types of bubbles and the potential impact of donor and lamella parameters on this frequency, and to identify possible risk factors of unsuccessful "big-bubble" creation in preparation of pre-Descemet endothelial keratoplasty and Descemet membrane endothelial keratoplasty with peripheral stromal support. METHODS: Donor age and sex, death to preservation time (DPT), storage time, presence of corneal scars (mainly a condition after cataract surgery), and endothelial cell density of 256 donor corneas were assessed before Descemet membrane endothelial keratoplasty with peripheral stromal support or pre-Descemet endothelial keratoplasty lamella preparation using the big-bubble technique...
April 26, 2018: Cornea
https://www.readbyqxmd.com/read/29705933/mesenchymal-stem-cells-form-3d-clusters-following-intraventricular-transplantation
#9
Nicole Jungwirth, Laura Salinas Tejedor, Wen Jin, Viktoria Gudi, Thomas Skripuletz, Veronika Maria Stein, Andrea Tipold, Andrea Hoffmann, Martin Stangel, Wolfgang Baumgärtner, Florian Hansmann
Mesenchymal stem cells (MSCs) are regarded as an immune privileged cell type with numerous regeneration-promoting effects. The in vivo behavior of MSC and underlying mechanisms leading to their regenerative effects are largely unknown. The aims of this study were to comparatively investigate the in vivo behavior of canine (cMSC), human (hMSC), and murine MSC (mMSC) following intra-cerebroventricular transplantation. At 7 days post transplantation (dpt), clusters of cMSC, hMSC, and mMSC were detected within the ventricular system...
April 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29693088/adenine-thymine-tautomerization-under-the-influence-of-strong-homogeneous-electric-fields
#10
Alya A Arabi, Chérif F Matta
The effect of strong electric fields on the tautomerization of the adenine-thymine (AT) base pair in DNA is explored using density functional theory. It was found that the AT base pair is not likely to undergo a double proton transfer reaction even in the presence of electric fields ranging from 5.14 × 108 to 5.14 × 109 V m-1. This conclusion holds true in Gibbs energies computed at 25 °C or 37 °C. Energy correction terms to the electronic energy, such as total internal energy, Gibbs energy, zero-point energy, enthalpy and entropy corrections, were investigated in detail to pinpoint the major contributors to the low probability of the AT tautomerization...
April 25, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29688547/neutron-characterization-of-ensa-dpt-type-spent-fuel-cask-at-trillo-nuclear-power-plant
#11
Roberto Méndez-Villafañe, Xandra Campo-Blanco, Miguel Embid, César A Yéboles, Ramón Morales, Manuel Novo, Javier Sanz
The Neutron Standards Laboratory of CIEMAT has conducted the characterization of the independent spent fuel storage installation at the Trillo Nuclear Power Plant. At this facility, the spent fuel assemblies are stored in ENSA-DPT type dual purpose casks. Neutron characterization was performed by dosimetry measurements with a neutron survey meter (LB6411) inside the facility, around an individual cask and between stored casks, and outside the facility. Spectra measurements were also performed with a Bonner sphere system in order to determine the integral quantities and validate the use of the neutron monitor at the different positions...
April 23, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29676661/atomistic-mechanisms-of-the-double-proton-transfer-in-the-h-bonded-nucleobase-pairs-qm-qtaim-computational-lessons
#12
Ol'ha O Brovarets', Dmytro M Hovorun
In this Review we have summarized and generalized the results of the investigation of the microstructural mechanisms of the tautomerisation by the counter movement of the protons along the neighboring intermolecular H-bonds in 22 biologically important pairs of nucleotide bases in the framework of the original method, which allows to trace the evolution of the physico-chemical parameters, that characterize these processes along the intrinsic reaction coordinate (IRC). It was demonstrated the performance of the introduction of the conception of the key points (KPs) (from nine to five, depending on the symmetry and nature of system), which exhaustively characterize the flow of the tautomerisation processes...
April 20, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29669369/cataract-surgery-in-high-hyperopia
#13
Nicolas Philipp Waldmann, Nadine Gerber, Warren Hill, David Goldblum
BACKGROUND: Although cataract surgery is a well-established and standardised procedure, it can be demanding and associated with higher complication rates in high hyperopia. We present clinical data for highly hyperopic patients who underwent cataract surgery over a 12-year period (2005 - 2016) and at a single centre. PATIENTS AND METHODS: Out of a total of 11 434 cataract operations, 41 highly hyperopic eyes (SN60AT ≥ 31 dpt) were included for analysis...
April 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29648497/low-reproducibility-between-oral-radiologists-and-general-dentists-with-regards-to-radiographic-diagnosis-of-caries
#14
Elmira Pakbaznejad Esmaeili, Tuomas Pakkala, Jari Haukka, Päivi Siukosaari
AIM: Early clinical and radiological diagnosis of dental caries is one of the fundamental objectives of clinical dentistry because of the high frequency of the disease and severe complications if caries remains untreated, especially among the elderly and patients with immunodeficiency. Dental panoramic tomography (DPT) is a common radiographic method for evaluating dentition when indicated, especially in an adult population. The aim of this study was to assess the reproducibility of diagnosis between specialists in oral radiology and general dentists with regards to caries lesions based on DPTs of adults...
April 12, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29618575/predicting-anti-tumor-effect-of-deoxypodophyllotoxin-in-nci-h460-tumor-bearing-mice-based-on-in-vitro-pharmacodynamics-and-physiologically-based-pharmacokinetic-pharmacodynamic-model
#15
Yang Chen, Kaijing Zhao, Fei Liu, Ying Li, Zeyu Zhong, Shijin Hong, Xiaodong Liu, Li Liu
Anti-tumor evaluation in tumor-bearing mouse is time- and energy-consuming. We aimed to investigate whether in vivo anti-tumor efficacy could be predicted based on in vitro pharmacodynamics using deoxypodophyllotoxin (DPT), a developing anti-tumor candidate, as a model compound. Proliferation kinetics of monolayer cultivated NCI-H460 cells under various DPT concentrations was quantitatively investigated accompanied by calibration curves. Koch's two-phase natural growth model combined with sigmoid Emax model, i...
April 4, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29604280/effect-of-a-contact-lens-for-in-vivo-mouse-retinal-imaging-effective-focal-length-changes-and-monochromatic-aberrations
#16
Pengfei Zhang, Jacopo Mocci, Daniel J Wahl, Ratheesh Kumar Meleppat, Suman K Manna, Martino Quintavalla, Riccardo Muradore, Marinko V Sarunic, Stefano Bonora, Edward N Pugh, Robert J Zawadzki
For in vivo mouse retinal imaging, especially with Adaptive Optics instruments, application of a contact lens is desirable, as it allows maintenance of cornea hydration and helps to prevent cataract formation during lengthy imaging sessions. However, since the refractive elements of the eye (cornea and lens) serve as the objective for most in vivo retinal imaging systems, the use of a contact lens, even with 0 Dpt. refractive power, can alter the system's optical properties. In this investigation we examined the effective focal length change and the aberrations that arise from use of a contact lens...
March 28, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29571739/title-translational-pk-pd-characterization-and-tmdd-modeling-of-an-anti-tfpi-antibody-pf-06741086
#17
Chuenlei Parng, Pratap Singh, Debra D Pittman, Katherine Wright, Beth Leary, Sunita Patel-Hett, Swapnil Rakhe, James Stejskal, Marjorie Peraza, Dawn Dufield, John E Murphy, Robert Webster
Tissue factor pathway inhibitor (TFPI) exhibits multiple isoforms which are known to present in multiple locations such as plasma, endothelium and platelets. TFPI is an endogenous negative modulator of the coagulation pathway, and therefore neutralization of TFPI function can potentially increase coagulation activity. A human monoclonal antibody, PF-06741086, which interacts with all isoforms of TFPI is currently being tested in clinic for treating hemophilia patients with and without inhibitors. To support clinical development of PF-06741086, pharmacokinetics (PK), and pharmacodynamics (PD) of PF-06741086 were characterized in monkeys...
March 20, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29562847/oral-provocation-testing-in-cutaneous-adverse-drug-reactions-to-antiretroviral-and-antitubercular-therapy-a-study-at-a-tertiary-care-hospital-in-south-india
#18
Sowmya Kaimal, Jithendriya Madhukara
AIM: To collect data pertaining to oral drug provocation testing (DPT) in hospitalized patients with antiretroviral (ARV)/antitubercular agent-induced rashes. METHODS: Patients with cutaneous adverse drug reactions (ADRs) to ARV/antitubercular drugs and who underwent oral DPT during a 5-year period were included in this study. RESULTS: Data were collected from the records of 21 patients. Of the 21, 19 had HIV infection. The most commonly implicated drug was nevirapine (NVP), followed by cotrimoxazole and antitubercular agents...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29560935/-individual-psychological-features-in-patients-with-computer-game-addiction-suffering-and-predisposed-persons
#19
R A Kardashian
AIM: To study personality characteristics in adolescents with computer game addiction. MATERIAL AND METHODS: The study included students of grades 7 to 10 at the age of 12-17 years (14.6±2.4 years), their parents and school teachers. RESULTS AND CONCLUSION: The results of a study showed the following combination in patients: 'genophilic' type of DPT with schizoid personality accentuation and 'projection' type of psychological protection, and 'dignitophilic' type of DPT with labile personality accentuation and 'denial' type of PP...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29559451/type-1-diabetes-trialnet-a-multifaceted-approach-to-bringing-disease-modifying-therapy-to-clinical-use-in-type-1-diabetes
#20
Polly J Bingley, Diane K Wherrett, Ann Shultz, Lisa E Rafkin, Mark A Atkinson, Carla J Greenbaum
What will it take to bring disease-modifying therapy to clinical use in type 1 diabetes? Coordinated efforts of investigators involved in discovery, translational, and clinical research operating in partnership with funders and industry and in sync with regulatory agencies are needed. This Perspective describes one such effort, Type 1 Diabetes TrialNet, a National Institutes of Health-funded and JDRF-supported international clinical trials network that emerged from the Diabetes Prevention Trial-Type 1 (DPT-1)...
April 2018: Diabetes Care
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