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https://www.readbyqxmd.com/read/27876815/variable-expressivity-and-genetic-heterogeneity-involving-dpt-and-sema3d-genes-in-autosomal-dominant-familial-meniere-s-disease
#1
Carmen Martín-Sierra, Alvaro Gallego-Martinez, Teresa Requena, Lidia Frejo, Angel Batuecas-Caletrío, Jose A Lopez-Escamez
Autosomal dominant (AD) familial Meniere's disease (FMD) is a rare disorder involving the inner ear defined by sensorineural hearing loss, tinnitus and episodic vertigo. Here, we have identified two novel and rare heterozygous variants in the SEMA3D and DPT genes segregating with the complete phenotype that have variable expressivity in two pedigrees with AD-FMD. A detailed characterization of the phenotype within each family illustrates the clinical heterogeneity in the onset and progression of the disease...
November 23, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27875536/capturing-dynamics-of-biased-attention-are-new-attention-variability-measures-the-way-forward
#2
Anne-Wil Kruijt, Andy P Field, Elaine Fox
BACKGROUND: New indices, calculated on data from the widely used Dot Probe Task, were recently proposed to capture variability in biased attention allocation. We observed that it remains unclear which data pattern is meant to be indicative of dynamic bias and thus to be captured by these indices. Moreover, we hypothesized that the new indices are sensitive to SD differences at the response time (RT) level in the absence of bias. METHOD: Randomly generated datasets were analyzed to assess properties of the Attention Bias Variability (ABV) and Trial Level Bias Score (TL-BS) indices...
2016: PloS One
https://www.readbyqxmd.com/read/27865769/discrepancies-in-the-diagnosis-and-classification-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity-reactions-in-children
#3
Tuğba Arikoglu, Gulen Aslan, Didem Derici Yildirim, Sehra Birgul Batmaz, Semanur Kuyucu
BACKGROUND: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently encountered in daily clinical practice. The aim of this study was to determine the confirmation rates, risk factors of NSAID hypersensitivity in children and to try to classify them with a standardized diagnostic protocol. METHODS: All patients with a suspicion of NSAID-induced hypersensitivity were evaluated with European Network for drug Allergy (ENDA) recommendations...
November 16, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27847980/incidence-of-schizophrenia-among-migrants-in-the-netherlands-a-direct-comparison-of-first-contact-longitudinal-register-approaches
#4
Simon J Hogerzeil, Albert M van Hemert, Wim Veling, Hans W Hoek
PURPOSE: To estimate the effect of selective sampling on first contact (FC) studies of the relation between migration and schizophrenia. METHODS: We compared the FC method directly with a more inclusive longitudinal psychiatric register (LPR) method, by letting both methods estimate age and sex adjusted incidence rate ratios (IRR) in the population of The Hague aged 20-54 years, for the three largest migrant groups (first and second generation Caribbean, Turkish, and Moroccan) relative to the native Dutch population...
November 15, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27829334/cellular-tests-for-the-evaluation-of-drug-hypersensitivity
#5
Adriana Ariza, Maria I Montañez, Tahia D Fernández, James R Perkins, C Mayorga
The diagnosis of drug hypersensitivity reactions (DHR) is complex, with many potential pitfalls. Although the use of clinical history and skin testing can be valuable, drug provocation testing (DPT) remains the gold standard for many DHR. However, DPT carries some potential risk and should not be performed for severe reactions. There is therefore a general consensus on the need for in vitro tests to achieve safe and accurate diagnosis of DHR. A range of in vitro approaches can be applied depending on the type of reaction and the immunological mechanism involved, i...
November 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27822628/-toric-add-on-intraocular-lenses-for-correction-of-high-astigmatism-after-pseudophakic-keratoplasty
#6
A Hassenstein, F Niemeck, K Giannakakis, M Klemm
Perforating keratoplasty shows good morphological results with a clear cornea; however, a limiting factor is often the resulting astigmatism, which cannot be corrected with either glasses or contact lenses (CL) in up to 20% of the patients. We retrospectively investigated 15 patients after pseudophakic perforating keratoplasty, who received implantation of toric add-on intraocular lenses (IOL) to correct astigmatism. The mean preoperative astigmatism of 6.5 diopter (dpt) could be reduced to a mean postoperative value of 1...
November 7, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27812740/dental-age-estimation-periodontal-ligament-visibility-plv-pattern-recognition-of-a-conclusive-mandibular-maturity-marker-related-to-the-lower-left-third-molar-at-the-18-year-threshold
#7
Victoria S Lucas, Fraser McDonald, Manoharan Andiappan, Graham Roberts
The purpose of this study was to explore the applicability of periodontal ligament visibility (PLV) at the 18-year threshold. This mandibular maturity marker is graded into four separate age related stages, PLV-A, PLV-B, PLV-C, and PLV-D. These are discernible on a dental panoramic tomograph (DPT). The sample comprised a total of 2000 DPTs evenly divided into half yearly age bands from 16.00 to 25.99 years with 50 females and 50 males in each age band. It was found that PLV-A and PLV-B had minimum values below the 18-year threshold...
November 3, 2016: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/27776400/effects-of-an-integrated-geriatric-group-balance-class-within-an-entry-level-doctorate-of-physical-therapy-program-on-students-perceptions-of-geriatrics-and-geriatric-education-in-the-united-states
#8
Jennifer C Reneker, Kyra Weems, Vincent Scaia
This study was aimed at determining the effect of an integrated group balance class for community-dwelling older adults within entry-level physical therapist coursework on student perceptions of geriatric physical therapy and geriatric physical therapy education. Twenty-nine Doctor of Physical Therapy (DPT) students, 21-33 years old, in their second year of coursework in 2012, participated in an integrated clinical experience with exposure to geriatric patients at an outpatient facility at the Louis Stokes Cleveland Department of Veterans Affairs Medical Center in Akron, Ohio, USA...
2016: Journal of Educational Evaluation for Health Professions
https://www.readbyqxmd.com/read/27774802/-relationship-between-corneal-surface-temperature-and-air-flow-conditions-during-refractive-laser-eye-surgery-using-three-different-excimer-lasers
#9
Csaba Szekrényesi, Gábor László Sándor, Andrea Gyenes, Huba Kiss, Tamás Filkorn, Zoltán Nagy
INTRODUCTION: Thermal conditions during photorefractive keratectomy might be an important issue related to the corneal wound healing and long-term outcomes. AIM: Authors tried to find out the importance of temperature conditions during the treatment. METHOD: One eye of 90 patients has been included into the study. Photorefractive keratoctomy was applied with Carl Zeiss MEL 70, MEL 80 and Wavelight Allegretto excimer lasers. EBRO TLC 730 infrared thermometer was used for the measurement of surface temperature of the cornea before epithelial removal, as well as before and after the treatment...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27736789/effects-of-in-feed-chlortetracycline-prophylaxis-of-beef-cattle-on-animal-health-and-antimicrobial-resistant-escherichia-coli
#10
Getahun E Agga, John W Schmidt, Terrance M Arthur
: Concerns have been raised that in-feed chlortetracycline (CTC) may increase antimicrobial resistance (AMR), specifically tetracycline-resistant (TET(r)) Escherichia coli, and third-generation cephalosporin-resistant (3GC(r)) E. coli We evaluated the impact of a 5-day in-feed CTC prophylaxis on animal health, TET(r) E. coli, and 3GC(r) E. coli A "control group" of cattle (n = 150) received no CTC, while a "CTC group" (n = 150) received in-feed CTC (10 mg/lb of body weight/day) from the 5th to the 9th day after feedlot arrival...
October 7, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27727032/the-roma-vaccination-gap-evidence-from-twelve-countries-in-central-and-south-east-europe
#11
Laetitia Duval, François-Charles Wolff, Martin McKee, Bayard Roberts
AIM: To investigate differences in vaccination coverage between Roma and otherwise comparable non-Roma children, including factors associated with the vaccination gap, health care access and discrimination faced by Roma. METHODS: We analyse data from the Roma Regional Survey 2011 implemented in twelve countries of Central and South-East Europe. Our sample comprises 8233 children aged up to 6 with 7072 Roma children and 1161 non-Roma children. Estimates of the Roma vaccination gap are estimated using Logit regressions...
October 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27702677/immune-reactivity-in-early-life-stages-of-sea-cage-cultured-pacific-bluefin-tuna-naturally-infected-with-blood-flukes-from-genus-cardicola-trematoda-aporocotylidae
#12
Ylenia Pennacchi, Sho Shirakashi, Barbara F Nowak, Andrew R Bridle
Pacific bluefin tuna (PBT), Thunnus orientalis, due to its high average price on the market is an economically valuable fish species. Infections by blood flukes from the genus Cardicola (Trematoda: Aporocotylidae) represent a growing concern for the cage culture of bluefin tuna in Japan, Australia and Southern Europe. The accumulation of numerous Cardicola eggs in the fish gills causes severe pathology that has been linked to mortality in PBT juveniles up to one year old. The only effective treatment used to mitigate the infection is the oral administration of the antihelminthic drug praziquantel (PZQ) to the affected fish...
October 1, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27698771/identification-of-the-protective-effects-of-traditional-medicinal-plants-against-sds-induced-drosophila-gut-damage
#13
Yang Zhou, Zonglin Liu, Yuchen Chen, Li Hua Jin
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 different plants used for the treatment of toxicity were screened for their in vivo protective effects. Flies were fed a standard cornmeal-yeast medium (control group) or the standard medium containing medicinal plant extracts (experimental groups). Assessment of the survival rate was performed by feeding flies with toxic compounds. Gut epithelial cells were analyzed for cell proliferation and death by green fluorescent protein antibodies and 7-aminoactinomycin D staining under the microscope...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27651285/comparing-three-cognitive-biases-for-alcohol-cues-in-alcohol-dependence
#14
Corinde E Wiers, Thomas E Gladwin, Vera U Ludwig, Sonja Gröpper, Heiner Stuke, Christiane K Gawron, Reinout W Wiers, Henrik Walter, Felix Bermpohl
AIMS: There is accumulating evidence that automatic processes play a large role in alcohol dependence, which may be related to alcohol craving and consumption. The aim of this study is to investigate associations between cognitive biases in alcohol-dependent patients, and how these measures relate to drinking behavior. METHODS: Thirty alcohol-dependent patients and 15 healthy controls (matched for age, intelligence and education; all male) completed three cognitive bias tasks: the Implicit Association Test (IAT: alcohol-approach association), Approach Avoidance Task (AAT: alcohol approach bias) and Dot Probe Task (DPT: alcohol attentional bias)...
September 20, 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27614990/characteristics-of-hyperautofluorescent-choroidal-vessels-using-fundus-camera-type-short-wavelength-autofluorescence
#15
Ari Shinojima, Ryusaburo Mori, Hiroyuki Nakashizuka, Hiroyuki Shimada
PURPOSE: To clarify differences between eyes showing hyperautofluorescent choroidal vessels in both nasal and temporal, or only the nasal, portions of the fundus using fundus autofluorescence. METHODS: Nineteen eyes with hyperautofluorescent vessels in both nasal and temporal portions (group 1) and 17 only the nasal portion (group 2) of the fundus were studied. Choroidal and retinal thicknesses (foveal, and nasal and temporal 3,000 µm from the fovea), axial length, and refraction were compared between the two groups...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27608521/survival-and-reproduction-of-onthophagus-landolti-coleoptera-scarabaeidae-exposed-to-ivermectin-residues-in-cattle-dung
#16
L C Pérez-Cogollo, R I Rodríguez-Vivas, E Reyes-Novelo, H Delfín-González, D Muñoz-Rodríguez
Two bioassays were conducted in parallel to assess the effects of cattle treated with either 1% ivermectin (IVM) or 3.15% IVM (dosed at 0.2 and 0.63 mg kg-1, respectively) on reproduction and survival of Onthophagus landolti Harold. Adult beetles were exposed 10 days to faeces of treated cattle starting at: one day before treatment (controls), 3, 6, 14, 28 and 35 days post-treatment. Adult survival of O. landolti was not affected by either of the two treatments. Faecal residues of 1% IVM almost completely suppressed fecundity of beetles at 3, 6 and 14 days post-treatment (dPT), and reduced fecundity of O...
September 9, 2016: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/27581655/effectiveness-of-a-smartphone-app-on-improving-immunization-of-children-in-rural-sichuan-province-china-a-cluster-randomized-controlled-trial
#17
Li Chen, Xiaozhen Du, Lin Zhang, Michelle Helena van Velthoven, Qiong Wu, Ruikan Yang, Ying Cao, Wei Wang, Lihui Xie, Xiuqin Rao, Yanfeng Zhang, Jeanne Catherine Koepsell
BACKGROUND: The aim of this study was to assess the effectiveness of an EPI smartphone application (EPI app) on improving vaccination coverage in rural Sichuan Province, China. METHODS: This matched-pair cluster randomized controlled study included 32 village doctors, matched in 16 pairs, and took place from 2013 to 2015. Village doctors in the intervention group used the EPI app and reminder text messages while village doctors in the control group used their usual procedures and text messages...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27578026/antitumor-effect-of-deoxypodophyllotoxin-on-human-breast-cancer-xenograft-transplanted-in-balb-c-nude-mice-model
#18
Meyada Khaled, Ghania Belaaloui, Zhen-Zhou Jiang, Xiong Zhu, Lu-Yong Zhang
Recently, biologically active compounds isolated from plants used in herbal medicine have been the center of interest. Deoxypodophyllotoxin (DPT), structurally closely related to the lignan podophyllotoxin, was found to be a potent antitumor and antiproliferative agent, in several tumor cells, in vitro. However, DPT has not been used clinically yet because of the lack of in vivo studies. This study is the first report demonstrating the antitumor effect of DPT on MDA-MB-231 human breast cancer xenografts in nude mice...
October 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27578017/alleviation-of-n-methyl-d-aspartate-receptor-dependent-long-term-depression-via-regulation-of-the-glycogen-synthase-kinase-3%C3%AE-pathway-in-the-amygdala-of-a-valproic-acid-induced-animal-model-of-autism
#19
Han-Fang Wu, Po See Chen, Yi-Ju Chen, Chi-Wei Lee, I-Tuan Chen, Hui-Ching Lin
The amygdala plays crucial roles in socio-emotional behavior and cognition, both of which are abnormal in autism spectrum disorder (ASD). Valproic acid (VPA)-exposed rat offspring have demonstrated ASD phenotypes and amygdala excitatory/inhibitory imbalance. However, the role of glutamatergic synapses in this imbalance remains unclear. In this study, we used a VPA-induced ASD-like model to assess glutamatergic synapse-dependent long-term depression (LTD) and depotentiation (DPT) in the amygdala. We first confirmed that the VPA-exposed offspring exhibited sociability deficits, anxiety, depression-like behavior, and abnormal nociception thresholds...
August 30, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27571553/diffusion-pseudotime-robustly-reconstructs-lineage-branching
#20
Laleh Haghverdi, Maren Büttner, F Alexander Wolf, Florian Buettner, Fabian J Theis
The temporal order of differentiating cells is intrinsically encoded in their single-cell expression profiles. We describe an efficient way to robustly estimate this order according to diffusion pseudotime (DPT), which measures transitions between cells using diffusion-like random walks. Our DPT software implementations make it possible to reconstruct the developmental progression of cells and identify transient or metastable states, branching decisions and differentiation endpoints.
October 2016: Nature Methods
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