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https://www.readbyqxmd.com/read/29146755/ocular-findings-in-loeys-dietz-syndrome
#1
Catharina Busch, Robert Voitl, Barbara Goergen, Tomasz Zemojtel, Petra Gehle, Daniel J Salchow
BACKGROUND: Loeys-Dietz syndrome (LDS), an autosomal-dominant connective tissue disorder, is characterised by systemic manifestations including arterial aneurysm and craniofacial dysmorphologies. Although ocular involvement in LDS has been reported, detailed information on those manifestations is lacking. METHODS: Retrospective chart review of patients with diagnosed LDS and comparison with age-matched control patients. RESULTS: Mean age was 37...
November 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29133981/electrostatic-interactions-between-polyglutamic-acid-and-polylysine-yields-stable-polyion-complex-micelles-for-deoxypodophyllotoxin-delivery
#2
Yutong Wang, Liping Huang, Yan Shen, Lidan Tang, Runing Sun, Di Shi, Thomas J Webster, Jiasheng Tu, Chunmeng Sun
To achieve enhanced physical stability of poly(ethylene glycol)-poly(d,l-lactide) polymeric micelles (PEG-PDLLA PMs), a mixture of methoxy PEG-PDLLA-polyglutamate (mPEG-PDLLA-PLG) and mPEG-PDLLA-poly(l-lysine) (mPEG-PDLLA-PLL) copolymers was applied to self-assembled stable micelles with polyion-stabilized cores. Prior to micelle preparation, the synthetic copolymers were characterized by (1)H-nuclear magnetic resonance (NMR) and infrared spectroscopy (IR), and their molecular weights were calculated by (1)H-NMR and gel permeation chromatography (GPC)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29119183/the-influence-of-thiolate-ligands-on-the-luminescence-properties-of-cycloplatinated-ii-complexes
#3
Mahboubeh Jamshidi, Mojgan Babaghasabha, Hamid R Shahsavari, S Masoud Nabavizadeh
Complexes [Pt(C(^)N)(PPh3)Cl] (C(^)N = bzq (7,8-benzoquinolinyl, A) and ppy (2-phenylpyridinyl, B)) were reacted with various thiolate ligands to afford complexes [Pt(C(^)N)(PPh3)(κ(1)-S-SR)], C(^)N = bzq, R = SPh (thiophenolate, 1a); C(^)N = ppy, R = SPh (1b); C(^)N = bzq, R = Spy (pyridine-2-thiolate, 2a); C(^)N = ppy, R = Spy (2b); C(^)N = bzq, R = SpyN (pyrimidine-2-thiolate, 3a); C(^)N = ppy, R = SpyN (3b). Complexes 1-3 were characterized by NMR spectroscopy, and the solid-state structures of 1a and 2a were determined by X-ray diffraction methods...
November 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29115446/effects-of-dermatopontin-gene-silencing-on-apoptosis-and-proliferation-of-osteosarcoma-mg%C3%A2-63-cells
#4
Li-Cheng Xi, Yun-Xi Ji, Dong Yin, Zi-Xing Zhao, Si-Cheng Huang, Shao-Lin Yu, Bo-Yu Liu, Hong-Yu Li
The present study aimed to investigate the effect of Dermatopontin (DPT) gene silencing on the apoptosis and proliferation of osteosarcoma MG‑63 cells. Three eukaryotic expression vectors of short hairpin (sh)RNA fragments targeting different loci of DPT were designed and transfected into an osteosarcoma cell line MG‑63. The cells were assigned to a blank, shRNA‑control, DPT‑shRNA‑a, DPT‑shRNA‑b or DPT‑shRNA‑c group. The shRNA with the highest silencing efficiency was screened using reverse transcription‑quantitative polymerase chain reaction and western blotting...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29095749/genetics-of-vestibular-syndromes
#5
Pablo Roman-Naranjo, Alvaro Gallego-Martinez, Jose A Lopez Escamez
PURPOSE OF REVIEW: The increased availability of next generation sequencing has enabled a rapid progress in the discovery of genetic variants associated with vestibular disorders. We have summarized molecular genetics finding in vestibular syndromes during the last 18 months. RECENT FINDINGS: Genetic studies continue to shed light on the genetic background of vestibular disorders. Novel genes affecting brain development and otolith biogenesis have been associated with motion sickness...
November 1, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29089875/hit-or-run-exploring-aggressive-and-avoidant-reactions-to-interpersonal-provocation-using-a-novel-fight-or-escape-paradigm-foe
#6
Frederike Beyer, Macià Buades-Rotger, Marie Claes, Ulrike M Krämer
Interpersonal provocation presents an approach-avoidance conflict to the provoked person: responding aggressively might yield the joy of retribution, whereas withdrawal can provide safety. Experimental aggression studies typically measure only retaliation intensity, neglecting whether individuals want to confront the provocateur at all. To overcome this shortcoming of previous measures, we developed and validated the Fight-or-Escape paradigm (FOE). The FOE is a competitive reaction time (RT) task in which the winner can choose the volume of a sound blast to be directed at his/her opponent...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29078638/subxiphoid-thymectomy-single-port-dual-port-and-robot-assisted
#7
Takashi Suda
Currently, surgical techniques that are less invasive than conventional median sternotomy are used for thymectomy in the treatment of myasthenia gravis and anterior mediastinal tumors as no sternal incision is required. We reported on a subxiphoid single-port thymectomy using CO2 insufflation, which has the following advantages: (I) the field of view offered by the camera scope inserted from the midline of the body helps confirm the location of the superior pole of the thymus and bilateral phrenic nerves; (II) there is minimal pain and no intercostal neuropathy occurs as intercostal spaces are not traversed; and (III) cosmetic outcomes are excellent...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29067468/resveratrol-improves-urinary-dysfunction-in-rats-with-chronic-prostatitis-and-suppresses-the-activity-of-the-stem-cell-factor-c-kit-signaling-pathway
#8
Yang Yu, Jiang Jiang, Yi He, Wei Wang, Chen Shen, Bo Yang
Chronic prostatitis (CP) is a common urological disorder, with bladder voiding dysfunction being the primary clinical manifestation. Resveratrol is polyphenolic compound isolated from numerous plants, with widely‑reported anti-inflammatory properties. The present study aimed to investigate whether resveratrol may improve overactive bladder in rats with CP and to investigate the underlying molecular mechanisms. Furthermore, the potential pharmacological synergy between resveratrol and solifenacin was also investigated as a potential treatment for CP...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29047169/non-immediate-reading-skin-tests-and-prolonged-challenges-in-non-immediate-hypersensitivity-to-beta-lactams-in-children
#9
G Lezmi, F Alrowaishdi, A Bados-Albiero, P Scheinmann, J de Blic, C Ponvert
BACKGROUND: A minority of children reporting non-immediate reactions to beta-lactams (BLs) are allergic. Allergy workup usually includes late-reading (48-72h) skin tests (ST) and short (1-3 days) drug provocation tests (DPT), regardless of the chronology of the index reaction. The sensitivity of hyper-late-reading (≥ 6-7 days) ST and of prolonged DPT for the diagnosis of non-immediate hypersensitiviy to BLs are yet to be determined. OBJECTIVES: To establish the diagnostic values of late- and hyper-late-reading ST and of prolonged DPT in children reporting non-immediate reactions to BLs...
October 19, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29031900/resveratrol-improved-detrusor-fibrosis-induced-by-mast-cells-during-progression-of-chronic-prostatitis-in-rats
#10
Yi He, Huizhi Zeng, Yang Yu, Jiashu Zhang, Qi Liu, Bo Yang
To investigate the detrusor fibrosis and urinary dysfunction in chronic prostatitis (CP), and to investigate whether resveratrol can improve the urinary dysfunction and the underlying molecular mechanism. After rat model of CP is established by subcutaneously injecting DPT vaccine, rats are treated with resveratrol. Experiments of bladder pressure and volume test in rats are used to investigate the effect of resveratrol on urinary dysfunction in CP rats. To assess tissue fibrosis, picrosirius red staining is performed...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28983392/effects-of-polio-eradication-activities-on-routine-immunization-lessons-from-the-2013-outbreak-response-in-somali-region-of-ethiopia
#11
Belete Tafesse, Ephrem Tekle, Liya Wondwossen, Mengistu Bogale, Braka Fiona, Peter Nsubuga, Karengera Tomas, Aron Kassahun, Gallagher Kathleen, Aschalew Teka
INTRODUCTION: Ethiopia experienced several WPV importations with a total of 10 WPV1 cases confirmed during the 2013 outbreak alone before it is closed in 2015. We evaluated supplemental immunization activities (SIAs), including lessons learned for their effect on the routine immunization program during the 2013 polio outbreak in Somali regional state. METHODS: We used descriptive study to review documents and analyse routine health information system reports from the polio outbreak affected Somali regional state...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983390/behavioral-determinants-of-immunization-service-utilization-in-ethiopia-a-cross-sectional-community-based-survey
#12
Yohannes Ababu, Fiona Braka, Aschalew Teka, Kinde Getachew, Tefera Tadesse, Yohannes Michael, Zewdie Birhanu, Peter Nsubuga, Tersit Assefa, Kathleen Gallagher
INTRODUCTION: According to the Ethiopian Health Sector Development Plan IV annual performance report (HSDP IV), Ethiopia targeted to reach 90% coverage with DPT-Hib-HepB 3 (Pentavalent3) vaccine and 86% coverage with measles vaccine in 2010- 2011. However, the actual performance fell-short of the intended targets due to several reasons. Therefore, a nationwide comprehensive study was conducted to examine the behavioral determinants of immunization practices in the Ethiopian context. The study employed the Modified Steps of Behavioral Change (SBC) Model as a theoretical lens...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28983260/common-marmosets-a-potential-translational-animal-model-of-juvenile-depression
#13
Nicole Leite Galvão-Coelho, Ana Cecília de Menezes Galvão, Flávia Santos da Silva, Maria Bernardete Cordeiro de Sousa
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28979898/a-novel-mutation-in-foxc1-in-a-lebanese-family-with-congenital-heart-disease-and-anterior-segment-dysgenesis-potential-roles-for-nfatc1-and-dpt-in-the-phenotypic-variations
#14
Athar Khalil, Christiane Al-Haddad, Hadla Hariri, Kamel Shibbani, Fadi Bitar, Mazen Kurban, Georges Nemer, Mariam Arabi
Congenital heart diseases (CHDs) are still the leading cause of death in neonates. Anterior segment dysgenesis is a broad clinical phenotype that affects the normal development of the eye, leading in most of the cases to glaucoma which is still a major cause of blindness for children and adolescents. Despite tremendous insights gained from genetic studies, a clear genotype-phenotype correlation is still difficult to draw. In Lebanon, a small country with still a high rate of consanguineous marriages, there are little data on the epidemiology of glaucoma amongst children with or without CHD...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28961620/physician-assistant-doctorate-a-ticket-to-autonomy
#15
Anthony A Miller, Bettie Coplan
As the physician assistant (PA) profession celebrates 5 decades of practice, questions about the future direction of PA education and practice persist. Conversations regarding prescribing privileges have given way to debate about PA certification and the necessary level of PA education. Most PA programs already confer master's degrees, but there has been at times vigorous debate on whether or not the PA profession should join pharmacy (PharmD), physical therapy (DPT), and advanced practice nursing (DNP) and standardize education at the clinical doctorate level...
October 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28959067/hepatitis-b-virus-surface-antigen-and-antibody-markers-in-children-at-a-major-paediatric-hospital-after-the-pentavalent-dtp-hbv-hib-vaccination
#16
Thomas Apiung, Thomas A Ndanu, Julius Aa Mingle, Kwamena Wc Sagoe
OBJECTIVES: The knowledge about outcomes of infant vaccination against HBV infections using the DPT-HepB-Hib vaccine in Ghana is limited. This study therefore investigated the levels of immunity to HBV among children who received the DPT-HepB-Hib vaccine and HBsAg carriage in non-responders. Correlates for non-response or poor response were also investigated. METHODS: Cross-sectional study. A major paediatric hospital in Accra. Four hundred and twenty four children between the ages of 5 to 32 months who had completed the full vaccination schedule for the DPT-HepB-Hib vaccine...
March 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/28949563/order-and-symmetry-breaking-in-the-fluctuations-of-driven-systems
#17
N Tizón-Escamilla, C Pérez-Espigares, P L Garrido, P I Hurtado
Dynamical phase transitions (DPTs) in the space of trajectories are one of the most intriguing phenomena of nonequilibrium physics, but their nature in realistic high-dimensional systems remains puzzling. Here we observe for the first time a DPT in the current vector statistics of an archetypal two-dimensional (2D) driven diffusive system and characterize its properties using the macroscopic fluctuation theory. The complex interplay among the external field, anisotropy, and vector currents in 2D leads to a rich phase diagram, with different symmetry-broken fluctuation phases separated by lines of first- and second-order DPTs...
September 1, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28947181/serotonergic-hallucinogens-in-the-treatment-of-anxiety-and-depression-in-patients-suffering-from-a-life-threatening-disease-a-systematic-review
#18
REVIEW
Simon Reiche, Leo Hermle, Stefan Gutwinski, Henrik Jungaberle, Peter Gasser, Tomislav Majić
Anxiety and depression are some of the most common psychiatric symptoms of patients suffering with life-threatening diseases, often associated with a low quality of life and a poor overall prognosis. 5-HT2A-receptor agonists (serotonergic hallucinogens, 'psychedelics') like lysergic acid diethylamide (LSD) and psilocybin were first investigated as therapeutic agents in the 1960s. Recently, after a long hiatus period of regulatory obstacles, interest in the clinical use of these substances has resumed. The current article provides a systematic review of studies investigating psychedelics in the treatment of symptoms of existential distress in life-threatening diseases across different periods of research, highlighting how underlying concepts have developed over time...
September 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28924923/plant-insects-and-mites-uptake-double-stranded-rna-upon-its-exogenous-application-on-tomato-leaves
#19
Anupam Gogoi, Nomi Sarmah, Athanasios Kaldis, Dionysios Perdikis, Andreas Voloudakis
Exogenously applied double-stranded RNA (dsRNA) molecules onto tomato leaves, moved rapidly from local to systemic leaves and were uptaken by agricultural pests namely aphids, whiteflies and mites. Four small interfering RNAs, deriving from the applied dsRNA, were molecularly detected in plants, aphids and mites but not in whiteflies. Double-stranded RNA (dsRNA) acts as the elicitor molecule of the RNA silencing (RNA interference, RNAi), the endogenous and evolutionary conserved surveillance system present in all eukaryotes...
December 2017: Planta
https://www.readbyqxmd.com/read/28923488/diagnostic-value-of-oral-challenge-testing-in-the-diagnosis-of-macrolide-hypersensitivity
#20
Derya Ünal, Semra Demir, Aslı Gelincik, Müge Olgaç, Raif Coşkun, Bahattin Çolakoğlu, Suna Büyüköztürk
BACKGROUND: Hypersensitivity reactions (HRs) to macrolides are rare. OBJECTIVE: The aim of this study was to evaluate the diagnostic value of in vivo tests in the diagnosis of HRs to macrolides and also to assess cross-reactivity between 4 different macrolides (clarithromycin, dirithromycin, spiramycin, and azithromycin) belonging to 3 different groups. METHODS: Twenty-five patients with a history of immediate or delayed-type HRs to at least 1 macrolide and 20 healthy control subjects underwent skin testing for both the culprit and alternative macrolides...
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
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