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https://www.readbyqxmd.com/read/28530439/an-eye-tracking-investigation-of-attentional-biases-towards-affect-in-young-children
#1
Jessica L Burris, Ryan A Barry-Anwar, Susan M Rivera
This study examines attentional biases in the presence of angry, happy and neutral faces using a modified eye tracking version of the dot probe task (DPT). Participants were 111 young children between 9 and 48 months. Children passively viewed an affective attention bias task that consisted of a face pairing (neutral paired with either neutral, angry or happy) for 500 ms that was followed by a 1,500-ms asterisk probe on 1 side of the screen. Congruent trials were trials in which the probe appeared on the same side of the screen as the emotional face and incongruent trials were trials in which the probe appeared on the opposite side of the emotional face...
May 22, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28527785/the-effectiveness-of-a-fixed-dose-combination-pour-on-formulation-of-1-25-fipronil-and-2-5-fluazuron-against-economically-important-ectoparasites-and-associated-pharmacokinetics-in-cattle
#2
Welber Daniel Zanetti Lopes, Rafael Marin Chiummo, Luis Fernando Vettorato, Daniel de Castro Rodrigues, Rafael Bazaglia Sonada
The present work consisted of eight studies to evaluate the ectoparasiticidal spectrum and determine the pharmacokinetic parameters of a pour-on combination of fipronil 1.25mg/kg+fluazuron 2.5mg/kg for cattle against Rhipicephalus microplus, Haematobia irritans and the larvae of Dermatobia hominis and Cochliomyia hominivorax. The analysis fipronil and fluazuron were performed by liquid chromatography using a mass detector for the detection and quantification of analytes (LC-MS/MS). Additionally, in two of these studies, the animals were artificially infested with R...
May 17, 2017: Parasitology International
https://www.readbyqxmd.com/read/28516358/mechanistic-modeling-of-the-pharmacodynamic-and-pharmacokinetic-relationship-of-tissue-factor-pathway-inhibitor-neutralizing-antibody-bay-1093884-in-cynomolgus-monkeys
#3
Jian-Ming Gu, Xiao-Yan Zhao, Thomas Schwarz, Joachim Schuhmacher, Andreas Baumann, Elena Ho, Babu Subramanyan, Kathy Tran, Timothy Myles, Chandra Patel, Maria Koellnberger
BAY 1093884 is a fully human monoclonal antibody against the tissue factor pathway inhibitor (TFPI) in development as prophylaxis in patients with hemophilia with or without inhibitors. In vitro, BAY 1093884 binds to human, mouse, and monkey TFPI. The objective of this study was to find a pharmacodynamic (PD) biomarker after administration of BAY 1093884 to normal monkeys. In monkey plasma, BAY 1093884 exhibited an IC50 (concentration that inhibits 50%) of 4.65 and 6.19 nM for free TFPI and diluted prothrombin time (dPT), respectively...
May 17, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28515054/longitudinal-decline-in-lung-function-among-older-construction-workers
#4
John M Dement, Laura S Welch, Knut Ringen, Kim Cranford, Patricia Quinn
BACKGROUND: Occupational exposures to vapours, gasses, dusts and fumes (VGDF) and chest X-ray abnormalities by the International Labour Office (ILO) classification system are associated with reduced lung function, with the majority of published studies being cross-sectional. We examined the effects of VGDF exposures, as well as ILO parenchymal changes, pleural plaque and diffuse pleural thickening (DPT) on reduction in lung function in a longitudinal study. METHODS: Chest radiographs and spirometry for 3150 ageing construction workers enrolled in a medical screening programme with a baseline and at least one follow-up examination were studied...
May 17, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28512358/delayed-epidural-transplantation-of-human-induced-pluripotent-stem-cell-derived-neural-progenitors-enhances-functional-recovery-after-stroke
#5
I-Hui Lee, Shiang-Suo Huang, Ching-Yu Chuang, Ko-Hsun Liao, Li-Hsin Chang, Chia-Chi Chuang, Yu-Shih Su, Hung-Jui Lin, Jui-Yu Hsieh, Shu-Han Su, Oscar Kuang-Sheng Lee, Hung-Chih Kuo
Induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) are a promising source of tailor-made cell therapy for neurological diseases. However, major obstacles to clinical use still exist. To circumvent complications related to intracerebral administration, we implanted human iPSC-NPCs epidurally over the peri-infarct cortex 7 days after permanent middle cerebral artery occlusion in adult rats. Compared to controls, cell-treated rats showed significant improvements in paretic forelimb usage and grip strength from 10 days post-transplantation (dpt) onwards, as well as reductions in lesion volumes, inflammatory infiltration and astrogliosis at 21 dpt...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28511010/%C3%AF-extended-and-curved-anti-aromatic-polycyclic-hydrocarbons
#6
Junzhi Liu, Ji Ma, Ke Zhang, Prince Ravat, Peter Machata, Stanislav M Avdoshenko, Felix Hennersdorf, Hartmut Komber, Wojciech Pisula, Jan J Weigand, Alexey A Popov, Reinhard Berger, Klaus Müllen, Xinliang Feng
Synthesis of anti-aromatic polycyclic hydrocarbons (PHs) is challenging because the high energy of their highest occupied molecular orbital (HOMO) and low energy of their lowest unoccupied molecular orbital (LUMO) cause them to be reactive and unstable. In this work, two large anti-aromatic acene analogues, namely cyclopenta[pqr]indeno[2,1,7-ijk]tetraphene (CIT, 1a) and cyclopenta[pqr]indeno[7,1,2-cde]picene (CIP, 1b), as well as a curved anti-aromatic molecule with 48 π-electrons, dibenzo[a,c]diindeno[7,1,2-fgh:7',1',2'-mno]phenanthro[9,10-k]tetraphene (DPT, 1c), are synthesized based on the corona of indeno[1,2-b]fluorene...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28493653/technology-assisted-parent-training-programs-for-children-and-adolescents-with-disruptive-behaviors-a-systematic-review
#7
Amit Baumel, Aditya Pawar, Nandita Mathur, John M Kane, Christoph U Correll
OBJECTIVE: To systematically review digitally assisted parent training programs (DPTs) targeting the treatment of children and adolescents with disruptive behaviors. DATA SOURCES: A search was conducted using PubMed, PsycINFO, and EMBASE databases for peer-reviewed studies published between January 1, 2000, and March 1, 2016. Reference lists of included and review articles were searched manually for additional references. STUDY SELECTION: Broad search terms in varying combinations for parent, training, technologies, and disruptive behavior problems were used...
May 9, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28480599/laboratory-accuracy-improvement-in-the-uk-neqas-leucocyte-immunophenotyping-immune-monitoring-programme-an-eleven-year-review-via-longitudinal-mixed-effects-modeling
#8
John Bainbridge, Wes Rountree, Raul Louzao, John Wong, Liam Whitby, Thomas N Denny, David Barnett
BACKGROUND: The United Kingdom National External Quality Assessment Service (UK NEQAS) for Leucocyte Immunophenotyping Immune Monitoring Programme, provides external quality assessment (EQA) to non-U.S. laboratories affiliated with the NIH NIAID Division of AIDS (DAIDS) clinical trials networks. Selected laboratories are required to have oversight, performance monitoring and remediation undertaken by Immunology Quality Assessment (IQA) staff under the DAIDS contract. We examined whether laboratory accuracy improves with longer EQA participation and whether IQA remediation is effective...
May 8, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28479621/increased-immunization-coverage-addresses-the-equity-gap-in-nepal
#9
Ashish Kc, Viktoria Nelin, Hendrikus Raaijmakers, Hyung Joon Kim, Chahana Singh, Mats Målqvist
OBJECTIVE: To compare immunization coverage and equity distribution of coverage between 2001 and 2014 in Nepal. METHODS: We used data from the Demographic and Health Surveys carried out in 2001, 2006 and 2011 together with data from the 2014 Multiple Indicator Cluster Survey. We calculated the proportion, in mean percentage, of children who had received bacille Calmette-Guérin (BCG) vaccine, three doses of polio vaccine, three doses of diphtheria-pertussis-tetanus (DPT) vaccine and measles vaccine...
April 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28472275/dental-age-comparison-in-patients-born-with-unilateral-cleft-lip-and-palate-to-a-control-sample-using-demirjian-and-willems-methods
#10
Nabeel Almotairy, Marie Pegelow
Objectives: To determine and compare the differences in dental age (DA) and chronological age (CA) of Demirjian and Willems methods in 9- to 11-year-old Caucasian boys and girls born with non-syndromic unilateral cleft lip and palate (NSUCLP) to an age-matched control group. Analysis of the results is undertaken to determine whether there are differences between gender, groups, and methods. Materials and methods: Dental panoramic tomograph (DPT) of 108 children with NSUCLP aged from 8...
May 2, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28470646/vitrectomy-with-fovea-sparing-internal-limiting-membrane-peeling-for-myopic-foveoschisis
#11
C Seppey, T J Wolfensberger
Background Myopic foveoschisis is a rare form of a tractional maculopathy, which occurs in patients with elevated axial length. The contraction of the posterior hyaloid exerts tangential traction on the retinal surface with a subsequent continuous splitting of the retinal layers. Internal limiting membrane (ILM) peeling has been advocated in foveoschisis, but it has been associated with post-operative macular hole formation. We report on a modified surgical technique, which spares the fovea and may reduce the risk for macular hole formation...
April 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28459105/crude-childhood-vaccination-coverage-in-west-africa-trends-and-predictors-of-completeness
#12
Jacob S Kazungu, Ifedayo M O Adetifa
Background: Africa has the lowest childhood vaccination coverage worldwide. If the full benefits of childhood vaccination programmes are to be enjoyed in sub-Saharan Africa, all countries need to improve on vaccine delivery to achieve and sustain high coverage. In this paper, we review trends in vaccination coverage, dropouts between vaccine doses and explored the country-specific predictors of complete vaccination in West Africa.  Methods: We utilized datasets from the Demographic and Health Surveys Program, available for Benin, Burkina Faso, The Gambia, Ghana, Guinea, Cote d'Ivoire, Liberia, Mali, Niger, Nigeria, Senegal, Sierra Leone and Togo, to obtain coverage for Bacillus Calmette-Guerin, polio, measles, and diphtheria, pertussis and tetanus (DPT) vaccines in children aged 12 - 23 months...
February 15, 2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28450745/contrasting-response-of-rainfall-extremes-to-increase-in-surface-air-and-dewpoint-temperatures-at-urban-locations-in-india
#13
Haider Ali, Vimal Mishra
Rainfall extremes are projected to increase under the warming climate. The Clausius-Clapeyron (C-C) relationship provides a physical basis to understand the sensitivity of rainfall extremes in response to warming, however, relationships between rainfall extremes and air temperature over tropical regions remain uncertain. Here, using station based observations and remotely sensed rainfall, we show that at a majority of urban locations, rainfall extremes show a negative scaling relationship against surface air temperature (SAT) in India...
April 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427662/ultrasonic-assisted-synthesis-of-a-tetrazine-functionalized-mof-and-its-application-in-colorimetric-detection-of-phenylhydrazine
#14
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Ali Morsali
TMU-34(-2H), [Zn(OBA)(DPT)0.5].DMF, has been sonochemically synthesized by applying H2OBA, (4,4'-oxybis(benzoic acid)), as the dicarboxylate linker, and DPT, (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), as pillar spacer. Sonication time, concentration of initial reagents, sonication power and molar ratio of pyridine as modulator has been optimized to synthesize nano powder of TMU-34(-2H) including uniform plate morphology. Nano TMU-34(-2H), can detect phenylhydrazine (PH) by color changing from pink to deep purple...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28417201/quantification-of-dynamic-posterior-translation-in-modified-bilateral-alexander-views-and-correlation-with-clinical-and-radiological-parameters-in-patients-with-acute-acromioclavicular-joint-instability
#15
Marvin Minkus, Carmen Hann, Markus Scheibel, Natascha Kraus
INTRODUCTION: Classification of AC-joint instability is based on radiologic evaluation of anteroposterior (a.p.) stress views of both shoulders, neglecting the horizontal component of instability. Recent studies have proposed an association of dynamic posterior translation (DPT) and inferior clinical results. The purpose of this study was to quantify DPT in modified Alexander views and correlate it with other radiological and clinical data. MATERIALS AND METHODS: Thirty-two patients (4 f, 28 m, mean age 34...
April 17, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28407859/establishment-of-intraperitoneal-germ-cell-transplantation-for-critically-endangered-chinese-sturgeon-acipenser-sinensis
#16
Huan Ye, Chuang-Ju Li, Hua-Mei Yue, Hao Du, Xiao-Ge Yang, Tasuku Yoshino, Takao Hayashida, Yutaka Takeuchi, Qi-Wei Wei
Recent progress in germ cell transplantation techniques in fish has paved the way for the conservation of endangered species. Here, we developed an intraperitoneal germ cell transplantation procedure using Chinese and Dabry's sturgeon as donor and recipient species, respectively. Histological analysis revealed that primordial germ cells migrated on the peritoneal wall at 16 days post-hatch (dph) in Dabry's sturgeon. The genital ridges of Dabry's sturgeon (recipient) first formed at 28 dph, suggesting that for successful colonization of donor germ cells in the recipient gonads, the transplantation should be performed earlier than this age...
May 2017: Theriogenology
https://www.readbyqxmd.com/read/28387150/improving-acl-reconstruction-outcomes
#17
Kevin E Wilk, Kurt P Spindler, Eric McCarty, Dustin Grooms, Karin Grävare Silbernagel
Anterior cruciate ligament (ACL) reconstruction is a common and predominantly successful surgical intervention. But are there specific preoperative patient characteristics or intraoperative surgeon decisions that lead to better or worse outcomes? And can understanding brain function changes of patients after ACL reconstruction reveal insights into the ways that postsurgical rehabilitation can be improved to further enhance outcomes? These intriguing and clinically applicable questions are addressed in this webinar titled "Improving ACL Reconstruction Outcomes," hosted jointly by JOSPT and JBJS...
March 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28377916/empowering-the-physiotherapy-profession-in-ethiopia-through-leadership-development-within-the-doctoring-process
#18
Cheryl Burditt Footer, Hailu Seifu Tsegaye, Tesfaye Asnake Yitnagashaw, Wintana Mekonnen, Tizita Destaw Shiferaw, Endashaw Abera, Alice Davis
Ethiopia recently introduced the Doctor of Physiotherapy (DPT) degree at Addis Ababa University as a mechanism to increase the work force capacity of primary care providers in the health sector. The DPT program was supported by an international academic partnership and was designed to empower physiotherapists as leaders to move the profession forward. The curriculum was framed by core pedagogical principles and strategies and was phased into two programs. First, the 4-year Advanced Standing DPT program focused on developing registered Ethiopian physiotherapists with Bachelor of Science degrees as academic faculty...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28368649/metamagnetic-anomalies-near-dynamic-phase-transitions
#19
P Riego, P Vavassori, A Berger
We report the existence of anomalous metamagnetic fluctuations in the vicinity of the dynamic phase transition (DPT) that do not occur for the corresponding thermodynamic behavior of simple ferromagnets. Our results demonstrate that key characteristics associated with the DPT are qualitatively different from conventional thermodynamic phase transitions. We also provide evidence that these differences are tunable by showing that the presence of metamagnetic fluctuations and the size of the critical scaling regime depend strongly on the amplitude of the oscillating field that is driving the DPT in the first place...
March 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28366048/biases-in-attention-and-interpretation-in-adolescents-with-varying-levels-of-anxiety-and-depression
#20
Anke M Klein, Leone de Voogd, Reinout W Wiers, Elske Salemink
This is the first study to investigate multiple cognitive biases in adolescence simultaneously, to examine whether anxiety and depression are associated with biases in attention and interpretation, and whether these biases are able to predict unique variance in self-reported levels of anxiety and depression. A total of 681 adolescents performed a Dot Probe Task (DPT), an Emotional Visual Search Task (EVST), and an Interpretation Recognition Task. Attention and interpretation biases were significantly correlated with anxiety...
April 3, 2017: Cognition & Emotion
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