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https://www.readbyqxmd.com/read/28226401/natural-evolution-in-patients-with-non-steroidal-anti-inflammatory-drugs-induced-urticaria-angioedema
#1
Inmaculada Doña, Esther Barrionuevo, María Salas, José Antonio Cornejo-García, James R Perkins, Gádor Bogas, Ana Prieto, María José Torres
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequent triggers of drug hypersensitivity with NSAIDs-induced urticaria/angioedema (NIUA) the most common phenotype. Loss of hypersensitivity has been reported for IgE-mediated reactions; however it has not been assessed in non-immunological reactions such as NIUA. We evaluated NSAID-hypersensitivity over time in NIUA patients. METHODS: Patients confirmed as NIUA by positive drug provocation test (DPT) with acetylsalicylic acid (ASA) during 2005-2012 (V1) were included (n=38)...
February 22, 2017: Allergy
https://www.readbyqxmd.com/read/28208264/scanning-electrochemical-microscopy-with-forced-convection-introduced-by-high-precision-stirring
#2
Christian Iffelsberger, Preety Vatsyayan, Frank-Michael Matysik
In the present report the well-known advantages of hydrodynamic mass transport in electrochemical systems are used in combination with scanning electrochemical microscopy (SECM). The hydrodynamic SECM system integrates a high-precision stirring device into the experimental setup. The well-defined stirring of the SECM electrolyte results in steady state diffusion layer characteristics in the vicinity of large substrate electrodes operated in chronoamperometric measuring mode. For a range of rotation frequencies of a rotating cylinder the thickness and the stability of the diffusion layer was studied by hydrodynamic SECM in the substrate generation/tip collection (SG/TC) as well as in the competition mode using ferrocene methanol as redox mediator...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28195718/improvement-of-methane-framework-interaction-by-controlling-pore-size-and-functionality-of-pillared-mofs
#3
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Timur Islamoglu, Ali Morsali, Yan Xu, Joseph T Hupp, Omar K Farha, Jun Wang, Peter C Junk
The rational design of functionalized porous metal-organic frameworks (MOFs) for gas adsorption applications has been applied using three spacer ligands H2DPT (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), DPT (3,6-di(pyridin-4-yl)-1,2,4,5-tetrazine), and BPDH (2,5-bis(4-pyridyl)-3,4-diaza-2,4-hexadiene) to synthesize TMU-34, [Zn(OBA)(H2DPT)0.5]n·DMF, TMU-34(-2H), [Zn(OBA)(DPT)0.5]n·DMF, and TMU-5, [Zn(OBA)(BPDH)0.5]n·1.5DMF, respectively. By controlling the pore size and chemical functionality of these three MOFs, we can improve the interactions between CO2 and especially CH4 with the frameworks...
February 14, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28192841/6-year-results-of-cnv-secondary-to-pathological-myopia-treated-with-ranibizumab
#4
L Hefner, H Gerding
Background The current standard treatment of choroidal neovascularisation (CNV) secondary to pathological myopia (PM) is intravitreal injection of VEGF antagonists. We now present our 6-year results after treating patients with CNV secondary to PM with ranibizumab. Patients and Methods We retrospectively analysed 15 treatment-naive eyes of 13 patients (10 women, 3 men, mean age 59.2; standard deviation (SD) 11.1; range 41-78 years) with visual impairment related to CNV secondary to PM, who were treated with at least 1 injection of ranibizumab...
February 13, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28191546/customized-care-an-intervention-to-improve-communication-and-health-outcomes-in-multimorbidity
#5
Marsha N Wittink, Sule Yilmaz, Patrick Walsh, Ben Chapman, Paul Duberstein
INTRODUCTION: Many primary care patients with multimorbidity (two or more chronic conditions) and depression or anxiety have day-to-day challenges that affect health outcomes, such as having financial or housing concerns, or dealing with social or emotional stressors. Yet, primary care providers (PCPs) are often unaware of patients' daily challenges coping with chronic disease. We developed Customized Care, an intervention, to address the barriers to effective communication about patient's day-to-day challenges...
December 15, 2016: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/28182410/luminescent-cyclometalated-platinum-complexes-with-%C3%AF-bonded-catecholate-organometallic-ligands
#6
Jamal Moussa, Aruny Loch, Lise-Marie Chamoreau, Alessandra Degli Esposti, Elisa Bandini, Andrea Barbieri, Hani Amouri
A series of cyclometalated platinum(II) complexes of the type [(ppy)Pt(LM)](n+) (n = 0, 1) with π-bonded catecholates acting as organometallic ligands (LM) have been prepared and characterized by analytical techniques. In addition, the structures of two complexes of the series were determined by single-crystal X-ray diffraction. The packing shows the formation of a 1D supramolecular assembly generated by dPt-πCp* interactions among individual units. All complexes are luminescent in the solid state and in solution media...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28122382/auditory-processing-in-children-with-migraine-a-controlled-study
#7
Larissa Mendonça Agessi, Thaís Rodrigues Villa, Deusvenir de Souza Carvalho, Liliane Desgualdo Pereira
Background This study aimed to investigate central auditory processing performance in children with migraine and compared with controls without headache. Methods Twenty-eight children of both sexes, aged between 8 and 12 years, diagnosed with migraine with and without aura, and a control group of the same age range and with no headache history, were included. Gaps-in-noise (GIN), duration pattern test (DPT), synthetic sentence identification (SSI) test, and nonverbal dichotic test (NVDT) were used to assess central auditory processing performance...
January 25, 2017: Neuropediatrics
https://www.readbyqxmd.com/read/28120698/short-course-daptomycin-lock-and-systemic-therapy-for-catheter-related-bloodstream-infections-a-retrospective-cohort-study-in-cancer-patients-with-surgically-implanted-devices
#8
Matteo Vassallo, Pierre-Luc Genillier, Brigitte Dunais, Regis Kaphan, Laurence Saudes, Yannick Duval, Fabien Rolland, Valerie Jullien, Nicolas Weiss, Elea Blanchouin, Annick Boscagli, Christophe Perrin, Nathalie Montagne
PURPOSE: Few in vivo studies have been reported describing efficacy and duration of antibiotic lock therapy (ALT) with daptomycin (DPT) for long-term catheter-related bloodstream infections (CRBSI) due to coagulase-negative staphylococci (CoNS). We retrospectively analysed the efficacy of short-course ALT with DPT in combination with systemic treatment (ST) for CoNS-associated CRBSI in our hospital. METHODS: Patients admitted for CoNS-associated CRBSI and treated with DPT as ALT and ST were retrospectively analysed...
January 25, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28057194/budget-impact-of-polio-immunization-strategy-for-india-introduction-of-one-dose-of-inactivated-poliomyelitis-vaccine-and-reductions-in-supplemental-polio-immunization
#9
M M Khan, S Sharma, B Tripathi, F P Alvarez
OBJECTIVES: To conduct a budget impact analysis (BIA) of introducing the immunization recommendations of India Expert Advisory Group (IEAG) for the years 2015-2017. The recommendations include introduction of one inactivated poliomyelitis vaccine (IPV) dose in the regular child immunization programme along with reductions in oral polio vaccine (OPV) doses in supplemental programmes. STUDY DESIGN: This is a national level analysis of budget impact of new polio immunization recommendations...
January 2017: Public Health
https://www.readbyqxmd.com/read/28018224/prediction-of-deoxypodophyllotoxin-disposition-in-mouse-rat-monkey-and-dog-by-physiologically-based-pharmacokinetic-model-and-the-extrapolation-to-human
#10
Yang Chen, Kaijing Zhao, Fei Liu, Qiushi Xie, Zeyu Zhong, Mingxing Miao, Xiaodong Liu, Li Liu
Deoxypodophyllotoxin (DPT) is a potential anti-tumor candidate prior to its clinical phase. The aim of the study was to develop a physiologically based pharmacokinetic (PBPK) model consisting of 13 tissue compartments to predict DPT disposition in mouse, rat, monkey, and dog based on in vitro and in silico inputs. Since large interspecies difference was found in unbound fraction of DPT in plasma, we assumed that Kt:pl,u (unbound tissue-to-plasma concentration ratio) was identical across species. The predictions of our model were then validated by in vivo data of corresponding preclinical species, along with visual predictive checks...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27999526/cme-cne-article-a-framework-of-care-in-multiple-sclerosis-part-1-updated-disease-classification-and-disease-modifying-therapy-use-in-specific-circumstances
#11
Scott D Newsome, Philip J Aliotta, Jacquelyn Bainbridge, Susan E Bennett, Gary Cutter, Kaylan Fenton, Fred Lublin, Dorothy Northrop, David Rintell, Bryan D Walker, Megan Weigel, Kathleen Zackowski, David E Jones
: Activity Available Online: To access the article, post-test, and evaluation online, go to http://www.cmscscholar.org. TARGET AUDIENCE: The target audience for this activity is physicians, physician assistants, nursing professionals, and other health-care providers involved in the management of patients with multiple sclerosis (MS). LEARNING OBJECTIVES: Apply new information about MS to a comprehensive individualized treatment plan for patients with MSIntegrate the team approach into long-term planning in order to optimize rehabilitation care of patients with MSAccreditation Statement: This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Consortium of Multiple Sclerosis Centers (CMSC), Nurse Practitioner Alternatives (NPA), and Delaware Media Group...
November 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27989625/pneumonia-prevention-cost-effectiveness-analyses-of-two-vaccines-among-refugee-children-aged-under-two-years-haemophilus-influenzae-type-b-containing-and-pneumococcal-conjugate-vaccines-during-a-humanitarian-emergency-yida-camp-south-sudan
#12
Lisa M Gargano, Rana Hajjeh, Susan T Cookson
By September 2013, war between Sudan and South Sudan resulted in >70,000 Sudanese refugees and high pneumonia incidence among the 20,000 refugees in Yida camp, South Sudan. Using Médecins Sans Frontières (MSF)-provided data and modifying our decision-tree models, we estimated if administering Haemophilus influenzae type b (Hib)-containing (pentavalent vaccine, also with diphtheria pertussis and tetanus [DPT] and hepatitis B) and pneumococcal conjugate (PCV) vaccines were cost-effective against hospitalized pneumonia...
January 11, 2017: Vaccine
https://www.readbyqxmd.com/read/27987347/integrated-analysis-reveals-candidate-mrna-and-their-potential-roles-in-uterine-leiomyomas
#13
Liping Xia, Yan Liu, Yan Fu, Shengyi Dongye, Dewei Wang
AIM: Uterine leiomyomas (UL) are the most common pelvic tumors, and the etiology and pathophysiology are not well understood. We aimed to elucidate the genes responsible for UL development. METHODS: Integrated analyses of four datasets of mRNA profiling for UL were performed. Functional annotation of differentially expressed genes (DEG) was used to systematically characterize the global expression profiles. The UL-specific protein-protein interaction network was constructed...
January 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27936077/routine-vaccination-coverage-in-northern-nigeria-results-from-40-district-level-cluster-surveys-2014-2015
#14
Rajni Gunnala, Ikechukwu U Ogbuanu, Oluwasegun J Adegoke, Heather M Scobie, Belinda V Uba, Kathleen A Wannemuehler, Alicia Ruiz, Hashim Elmousaad, Chima J Ohuabunwo, Mahmud Mustafa, Patrick Nguku, Ndadilnasiya Endie Waziri, John F Vertefeuille
BACKGROUND: Despite recent success towards controlling poliovirus transmission, Nigeria has struggled to achieve uniformly high routine vaccination coverage. A lack of reliable vaccination coverage data at the operational level makes it challenging to target program improvement. To reliably estimate vaccination coverage, we conducted district-level vaccine coverage surveys using a pre-existing infrastructure of polio technical staff in northern Nigeria. METHODS: Household-level cluster surveys were conducted in 40 polio high risk districts of Nigeria during 2014-2015...
2016: PloS One
https://www.readbyqxmd.com/read/27876815/variable-expressivity-and-genetic-heterogeneity-involving-dpt-and-sema3d-genes-in-autosomal-dominant-familial-meniere-s-disease
#15
Carmen Martín-Sierra, Alvaro Gallego-Martinez, Teresa Requena, Lidia Frejo, Angel Batuecas-Caletrío, Jose A Lopez-Escamez
Autosomal dominant (AD) familial Meniere's disease (FMD) is a rare disorder involving the inner ear defined by sensorineural hearing loss, tinnitus and episodic vertigo. Here, we have identified two novel and rare heterozygous variants in the SEMA3D and DPT genes segregating with the complete phenotype that have variable expressivity in two pedigrees with AD-FMD. A detailed characterization of the phenotype within each family illustrates the clinical heterogeneity in the onset and progression of the disease...
February 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27875536/capturing-dynamics-of-biased-attention-are-new-attention-variability-measures-the-way-forward
#16
Anne-Wil Kruijt, Andy P Field, Elaine Fox
BACKGROUND: New indices, calculated on data from the widely used Dot Probe Task, were recently proposed to capture variability in biased attention allocation. We observed that it remains unclear which data pattern is meant to be indicative of dynamic bias and thus to be captured by these indices. Moreover, we hypothesized that the new indices are sensitive to SD differences at the response time (RT) level in the absence of bias. METHOD: Randomly generated datasets were analyzed to assess properties of the Attention Bias Variability (ABV) and Trial Level Bias Score (TL-BS) indices...
2016: PloS One
https://www.readbyqxmd.com/read/27865769/discrepancies-in-the-diagnosis-and-classification-of-nonsteroidal-anti-inflammatory-drug-hypersensitivity-reactions-in-children
#17
Tuğba Arikoglu, Gulen Aslan, Didem Derici Yildirim, Sehra Birgul Batmaz, Semanur Kuyucu
BACKGROUND: Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently encountered in daily clinical practice. The aim of this study was to determine the confirmation rates, risk factors of NSAID hypersensitivity in children and to try to classify them with a standardized diagnostic protocol. METHODS: All patients with a suspicion of NSAID-induced hypersensitivity were evaluated with European Network for drug Allergy (ENDA) recommendations...
November 16, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27847980/incidence-of-schizophrenia-among-migrants-in-the-netherlands-a-direct-comparison-of-first-contact-longitudinal-register-approaches
#18
Simon J Hogerzeil, Albert M van Hemert, Wim Veling, Hans W Hoek
PURPOSE: To estimate the effect of selective sampling on first contact (FC) studies of the relation between migration and schizophrenia. METHODS: We compared the FC method directly with a more inclusive longitudinal psychiatric register (LPR) method, by letting both methods estimate age and sex adjusted incidence rate ratios (IRR) in the population of The Hague aged 20-54 years, for the three largest migrant groups (first and second generation Caribbean, Turkish, and Moroccan) relative to the native Dutch population...
November 15, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27829334/cellular-tests-for-the-evaluation-of-drug-hypersensitivity
#19
Adriana Ariza, Maria I Montañez, Tahia D Fernández, James R Perkins, C Mayorga
The diagnosis of drug hypersensitivity reactions (DHR) is complex, with many potential pitfalls. Although the use of clinical history and skin testing can be valuable, drug provocation testing (DPT) remains the gold standard for many DHR. However, DPT carries some potential risk and should not be performed for severe reactions. There is therefore a general consensus on the need for in vitro tests to achieve safe and accurate diagnosis of DHR. A range of in vitro approaches can be applied depending on the type of reaction and the immunological mechanism involved, i...
November 7, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27822628/-toric-add-on-intraocular-lenses-for-correction-of-high-astigmatism-after-pseudophakic-keratoplasty
#20
A Hassenstein, F Niemeck, K Giannakakis, M Klemm
Perforating keratoplasty shows good morphological results with a clear cornea; however, a limiting factor is often the resulting astigmatism, which cannot be corrected with either glasses or contact lenses (CL) in up to 20% of the patients. We retrospectively investigated 15 patients after pseudophakic perforating keratoplasty, who received implantation of toric add-on intraocular lenses (IOL) to correct astigmatism. The mean preoperative astigmatism of 6.5 diopter (dpt) could be reduced to a mean postoperative value of 1...
November 7, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
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