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https://www.readbyqxmd.com/read/28213663/a-historical-glance-at-the-arabo-islamic-surgical-instruments-during-the-ages
#1
Gregory Tsoucalas, Markos Sgantzos
Arabo-Islamic physicians demonstrated exceptional skill and innovation in surgery, by having used the instruments introduced by ancient Greeks and Greco-Roman surgeons. In many cases they have manufactured their own innovative designs promoting further the success of the difficult surgical operations of their era. The surgical instruments and the surgeon's boxes, used to regularise the plethora of the metallic items, were decorated with fine designs, in order to depict the Arab civilisation. For the first time surgery became a separate medical art, while Arabo-Islamic medicine re-introduced ancient Greek and Byzantine surgery to the world...
February 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28210022/csf-related-complications-after-intradural-spinal-tumor-surgery-utility-of-an-autologous-fat-graft
#2
Kenan I Arnautovic, Marko Kovacevic
OBJECT: The incidence of cerebrospinal fluid (CSF)-related complications after intradural spinal tumor (IST) surgery is high and reported in up to 18% of patients. However, no efficient way to prevent those complications has been reported so far. Treating these complications may require prolonged bed rest, re-exploration, external lumbar drain, use of antibiotics, and possible precipitation of other complications. To alleviate the risk of CSF-related complications, we prospectively adopted the intraoperative use of autologous fat grafting after IST surgery...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209222/roles-of-angiotensin-peptides-and-recombinant-human-ace2-in-heart-failure
#3
Ratnadeep Basu, Marko Poglitsch, Haran Yogasundaram, Jissy Thomas, Brian H Rowe, Gavin Y Oudit
BACKGROUND: The renin-angiotensin system (RAS) is activated in heart failure (HF) and inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and its product, angiotensin 1-7 (Ang-[1-7]), are important negative regulators of the RAS. OBJECTIVES: A comprehensive examination of angiotensin peptide levels and therapeutic effects of recombinant human ACE2 (rhACE2) on peptide metabolism was evaluated in human plasma and explanted heart tissue from patients with HF...
February 21, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28206679/technical-note-determination-of-individual-thyroid-clearance-effective-half-life-with-a-common-handheld-electronic-dosimeter
#4
Markus Fürstner, Michael Hentschel, Petar-Marko Spanjol, George A Prenosil, Sabine Weidner, Thomas Krause, Bernd Klaeser
PURPOSE: To determine the thyroid clearance effective half-life (Ʈ) with a common handheld electronic dosimeter (ED) in patients undergoing radioiodine treatment for hyperthyroidism. METHODS: Dose rates from twelve inpatients were measured daily with an ED and with a clinical uptake counter. The ED was attached to the patient with two different setups, one using a cervical collar and another employing a neck strap. Estimation of Ʈ was performed by linear regression analysis of the log of both the ED and the uptake counter measurements versus time...
February 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28204981/phase-1b-trial-of-proteasome-inhibitor-carfilzomib-with-irinotecan-in-lung-cancer-and-other-irinotecan-sensitive-malignancies-that-have-progressed-on-prior-therapy-onyx-ist-reference-number-car-ist-553
#5
Susanne M Arnold, Kari Chansky, Markos Leggas, Michael A Thompson, John L Villano, John Hamm, Rachel E Sanborn, Glen J Weiss, Gurkamal Chatta, Maria Q Baggstrom
Introduction Proteasome inhibition is an established therapy for many malignancies. Carfilzomib, a novel proteasome inhibitor, was combined with irinotecan to provide a synergistic approach in relapsed, irinotecan-sensitive cancers. Materials and Methods Patients with relapsed irinotecan-sensitive cancers received carfilzomib (Day 1, 2, 8, 9, 15, and 16) at three dose levels (20/27 mg/m2, 20/36 mg/m2 and 20/45 mg/m2/day) in combination with irinotecan (Days 1, 8 and 15) at 125 mg/m2/day. Key eligibility criteria included measurable disease, a Zubrod PS of 0 or 1, and acceptable organ function...
February 16, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28202486/granulocytic-sarcoma-a-rare-cause-of-sciatica
#6
Epaminondas Markos Valsamis, Thomas Edward Glover
We describe a case report of a man aged 56 years with a 4-month history of right-sided sciatica-type pain with subclinical disc prolapse evident on MRI. Worsening pain together with the appearance of a tender mass in his right buttock prompted further imaging, which demonstrated an infiltrative mass engulfing the lumbosacral plexus. This was later shown to be a granulocytic sarcoma on biopsy. Intervertebral disc herniation can be an incidental finding and is not always the cause of sciatica.
February 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28199094/two-unprecedented-pom-based-inorganic-organic-hybrids-with-concomitant-heteropolytungstate-and-molybdate
#7
Yun-Wu Li, Ling-Yu Guo, Hai-Feng Su, Marko Jagodič, Ming Luo, Xiao-Qi Zhou, Su-Yuan Zeng, Chen-Ho Tung, Di Sun, Lan-Sun Zheng
Two novel POM-based inorganic-organic hybrids, [Cu6(II)(2,2'-bipy)6(Mo6O22)(SiW12O40)]n (1), and {[Cu6(II)(ppz)6(H2O)5(MoO4)(SiW12O40)]·4H2O}n (2) (2,2'-bipy = 2,2'-bipyridine, Hppz = 3-(pyrid-2-yl)pyrazole), have been constructed from heteropolytungstates and molybdates. Two compounds have been identified by single crystal X-ray diffraction, elemental analysis, and FT-IR. Compound 1 shows a 1D (one-dimensional) chain structure constructed from classical Keggin heteropolytungstate [SiW12O40](4-) clusters and [Cu6(2,2'-bipy)6] modified isopolymolybdates [Mo6O22](8-)...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28198616/comparison-of-metals-and-tetracycline-as-selective-agents-for-development-of-tetracycline-resistant-bacterial-communities-in-agricultural-soil
#8
Jianxiao Song, Christopher Rensing, Peter E Holm, Marko P J Virta, Kristian Koefoed Brandt
Environmental selection of antibiotic resistance may be caused by either antibiotic residues or by co-selecting agents such as toxic metals. Using a strictly controlled experimental design we compared the ability of metals (Cu or Zn) and tetracycline to (co)select for tetracycline resistance at thein bacterial community communitieslevel. Soil microcosms were established by amending agricultural soil with known levels of Cu, Zn or tetracycline known to represent commonly used metals and antibiotics for pig farming...
February 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28197616/co-iii-complexes-of-1-3-selenazol-2-yl-hydrazones-and-their-sulphur-analogues
#9
Nenad R Filipović, Hana Elshaflu, Sonja Grubišić, Ljiljana S Jovanović, Marko Rodić, Irena Novaković, Aleksandar Malešević, Ivana S Djordjević, Haidong Li, Nešo Šojić, Aleksandar Marinković, Tamara R Todorović
The first Co(iii) complexes with (1,3-selenazol-2-yl)hydrazones as an unexplored class of ligands were prepared and characterized by NMR spectroscopy and X-ray diffraction analysis. The novel ligands act as NNN tridentate chelators forming octahedral Co(iii) complexes. The impact of structural changes on ligands' periphery as well as that of isosteric replacement of sulphur with selenium on the electrochemical and electronic absorption features of complexes are explored. To support the experimental data, density functional theory (DFT) calculations were also conducted...
February 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28195460/correction-to-raman-characterization-of-the-charge-density-wave-phase-of-1t-tise2-from-bulk-to-atomically-thin-layers
#10
Dinh Loc Duong, Gihun Ryu, Alexander Hoyer, Chengtian Lin, Marko Burghard, Klaus Kern
No abstract text is available yet for this article.
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28195374/development-of-polar-order-by-liquid-crystal-self-assembly-of-weakly-bent-molecules
#11
Mohamed Alaasar, Marko Prehm, Silvio Poppe, Carsten Tschierske
Organic ferroelectrics are of growing importance for multifunctional materials. Here we provide an understanding of the distinct stages of the development of sterically induced polar order in liquid crystalline (LC) soft matter. Three series of weakly bent molecules derived from 4-cyanoresorcinol as the bent core unit with laterally fluorinated azobenzene wings have been synthesized and the effects of the position of fluorine substitution, alkyl chain length and temperature on the LC self-assembly and polar order were studied...
February 13, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28192993/quantitative-affinity-determination-by-fluorescence-anisotropy-measurements-of-individual-nanoliter-droplets
#12
Fabrice Gielen, Maren Butz, Eric J Rees, Miklos Erdelyi, Tommaso Moschetti, Marko Hyvönen, Joshua B Edel, Clemens F Kaminski, Florian Hollfelder
Fluorescence anisotropy measurements of reagents compartmentalized into individual nanoliter droplets are shown to yield high-resolution binding curves from which precise dissociation constants (Kd) for protein-peptide interactions can be inferred. With the current platform, four titrations can be obtained per minute (based on ∼100 data points each), with stoichiometries spanning more than 2 orders of magnitude and requiring only tens of microliters of reagents. In addition to affinity measurements with purified components, Kd values for unpurified proteins in crude cell lysates can be obtained without prior knowledge of the concentration of the expressed protein, so that protein purification can be avoided...
January 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28188928/the-papain-like-cysteine-proteinases-nbcysp6-and-nbcysp7-are-highly-processive-enzymes-with-substrate-specificities-complementary-to-nicotiana-benthamiana-cathepsin-b
#13
Melanie Paireder, Stefan Tholen, Andreas Porodko, Martin L Biniossek, Bettina Mayer, Marko Novinec, Oliver Schilling, Lukas Mach
The tobacco-related plant Nicotiana benthamiana is gaining interest as a versatile host for the production of monoclonal antibodies and other protein therapeutics. However, the susceptibility of plant-derived recombinant proteins to endogenous proteolytic enzymes limits their use as biopharmaceuticals. We have now identified two previously uncharacterized N. benthamiana proteases with high antibody-degrading activity, the papain-like cysteine proteinases NbCysP6 and NbCysP7. Both enzymes are capable of hydrolysing a wide range of synthetic substrates, although only NbCysP6 tolerates basic amino acids in its specificity-determining S2 subsite...
February 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28188395/marshall-r-urist-and-the-discovery-of-bone-morphogenetic-proteins
#14
Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs...
February 11, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28188080/the-effect-of-18f-fdg-pet-image-reconstruction-algorithms-on-the-expression-of-characteristic-metabolic-brain-network-in-parkinson-s-disease
#15
Petra Tomše, Luka Jensterle, Sebastijan Rep, Marko Grmek, Katja Zaletel, David Eidelberg, Vijay Dhawan, Yilong Ma, Maja Trošt
PURPOSE: To evaluate the reproducibility of the expression of Parkinson's Disease Related Pattern (PDRP) across multiple sets of 18F-FDG-PET brain images reconstructed with different reconstruction algorithms. METHODS: 18F-FDG-PET brain imaging was performed in two independent cohorts of Parkinson's disease (PD) patients and normal controls (NC). Slovenian cohort (20 PD patients, 20 NC) was scanned with Siemens Biograph mCT camera and reconstructed using FBP, FBP+TOF, OSEM, OSEM+TOF, OSEM+PSF and OSEM+PSF+TOF...
February 7, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28187733/early-detection-of-copd-patients-in-gold-0-population-an-observational-non-interventional-cohort-study-marko-study
#16
Žarko Vrbica, Marina Labor, Ivan Gudelj, Slavica Labor, Iva Jurić, Davor Plavec
BACKGROUND: Main risk factor for the development of chronic obstructive pulmonary disease (COPD) is smoking, although only less than 1/3 of smokers develop clinically manifest COPD. COPD's progressive nature with high disability and mortality makes it plausible to detect it as early as possible thus allowing for an early intervention. The only tool for an early diagnosis that could be used on the global scale is spirometry, even though symptoms and deprivation of health related quality of life (HRQoL) precede relevant spirometric changes...
February 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28187207/a-multi-objective-constraint-based-approach-for-modeling-genome-scale-microbial-ecosystems
#17
Marko Budinich, Jérémie Bourdon, Abdelhalim Larhlimi, Damien Eveillard
Interplay within microbial communities impacts ecosystems on several scales, and elucidation of the consequent effects is a difficult task in ecology. In particular, the integration of genome-scale data within quantitative models of microbial ecosystems remains elusive. This study advocates the use of constraint-based modeling to build predictive models from recent high-resolution -omics datasets. Following recent studies that have demonstrated the accuracy of constraint-based models (CBMs) for simulating single-strain metabolic networks, we sought to study microbial ecosystems as a combination of single-strain metabolic networks that exchange nutrients...
2017: PloS One
https://www.readbyqxmd.com/read/28186066/end-users-voice-in-ehr-selection-development-of-a-usability-questionnaire-for-demonstrations-in-procurement-dpuq
#18
Mari Tyllinen, Johanna Kaipio, Tinja Lääveri, Marko Nieminen
This paper describes the development of a questionnaire for evaluating usability during EHR system procurement (DPUQ). Established usability questionnaires can be used to gather user feedback after using the systems. However, during procurement, experimenting with real system use is practical only with a limited number of system candidates. There is a need for less resource-demanding usability evaluation in the early stages of procurement in cases with several vendors. DPUQ has been designed for usability evaluation by end-users during special scenario-based vendor demonstrations...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28186053/aim-agile-instrumented-monitoring-for-improving-user-experience-of-participation-in-healthit-development
#19
Janne Pitkänen, Marko Nieminen
Participation of healthcare professionals in information technology development has emerged as an important challenge. As end-users, the professionals are willing to participate in the development activities, but their experiences on the current methods of participation remain mostly negative. There is lack of applicable methods for meeting the needs of agile development approach and scaling up to the largest implementation projects, while maintaining the interest of the professional users to participate in development activities and keeping up their ability to continue working in a productive manner...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28185991/formulation-and-characterization-of-nanofibers-and-films-with-carvedilol-prepared-by-electrospinning-and-solution-casting-method
#20
Marko Krstić, Marija Radojević, Dušica Stojanović, Vesna Radojević, Petar Uskoković, Svetlana Ibrić
The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO...
February 6, 2017: European Journal of Pharmaceutical Sciences
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