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https://www.readbyqxmd.com/read/28729262/genome-sequence-of-canine-polyomavirus-in-respiratory-secretions-of-dogs-with-pneumonia-of-unknown-etiology
#1
Eric Delwart, Beatrix Kapusinszky, Patricia A Pesavento, Marko Estrada, M Alexis Seguin, Christian M Leutenegger
We report here the first canine polyomavirus genome, identified by metagenomics in respiratory secretions of two dogs with severe pneumonia, which tested negative for all canine respiratory pathogens except Mycoplasma cynos The isolate, Canis familiaris polyomavirus 1 (DogPyV-1), is a beta polyomavirus whose closest known LT antigen relatives are primate polyomaviruses.
July 20, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28728829/short-term-double-natural-orifice-catheterization-nonoperative-management-of-hydrocolpos-in-persistent-cloaca-patients-case-series
#2
Stjepan Višnjić, Mislav Bastić, Mateja Marčec, Marko Mesić
PURPOSE: Management of hydrocolpos in cloaca patients is of clinical importance. We report a nonoperative method for the management of hydrocolpos in the form of initial catheter decompression, followed by an endoscopy with catheters placement into both the bladder and vagina, and leaving these catheters for 9 and 14days respectively. METHODS: The medical records of six cloaca patients with hydrocolpos in the last 12years were reviewed. The outcomes measured were the renal function, bladder emptying, the presence/resolution of hydronephrosis, and the recurrence of hydrocolpos...
June 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28727501/validation-of-the-dominant-sequence-paradigm-and-role-of-dynamic-contrast-enhanced-imaging-in-pi-rads-version-2
#3
Matthew D Greer, Joanna H Shih, Nathan Lay, Tristan Barrett, Leonardo Kayat Bittencourt, Samuel Borofsky, Ismail M Kabakus, Yan Mee Law, Jamie Marko, Haytham Shebel, Francesca V Mertan, Maria J Merino, Bradford J Wood, Peter A Pinto, Ronald M Summers, Peter L Choyke, Baris Turkbey
Purpose To validate the dominant pulse sequence paradigm and limited role of dynamic contrast material-enhanced magnetic resonance (MR) imaging in the Prostate Imaging Reporting and Data System (PI-RADS) version 2 for prostate multiparametric MR imaging by using data from a multireader study. Materials and Methods This HIPAA-compliant retrospective interpretation of prospectively acquired data was approved by the local ethics committee. Patients were treatment-naïve with endorectal coil 3-T multiparametric MR imaging...
July 19, 2017: Radiology
https://www.readbyqxmd.com/read/28724167/in-vitro-controlled-release-of-two-new-tuberculocidal-adamantane-aminoethers-from-solid-pharmaceutical-formulations-ii
#4
Marilena Vlachou, Angeliki Siamidi, Dimitrios Spaneas, Dimitrios Lentzos, Polixeni Ladia, Konstantina Anastasiou, Ioannis Papanastasiou, Angeliki-Sofia Foscolos, Markos-Orestis Georgiadis, Vangelis Karalis, Tahsin Kellici, Thomas Mavromoustakos
The aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of two new tuberculocidal adamantane aminoethers (compounds III and IV), congeneric to the adamantane derivative SQ109, which is in final clinical trials, and aminoethers (I) and (II), using carefully selected excipients, such as polyvinylpyrrolidone, sodium alginate and lactose. The tablets were prepared using the direct compression method and dissolution experiments were conducted using the US Pharmacopoeia type II apparatus (paddle method) in gastric and intestinal fluids...
July 19, 2017: Drug Research
https://www.readbyqxmd.com/read/28723285/case-244-systemic-amyloidosis-a-complication-of-waldenstr%C3%A3-m-macroglobulinemia
#5
Maja Hrabak-Paar, Marko Kralik
History A 68-year-old man was admitted to the hospital for work-up because of generalized fatigue, anorexia, chronic diarrhea, and weight loss. Laboratory work-up revealed an erythrocyte sedimentation rate of 58 mm/h (reference range, 3-23 mm/h), a hemoglobin level of 14.1 g/dL (reference range, 13.8-17.5 g/dL), a leukocyte count of 8.1 × 10(9)/L (reference range, [3.4-9.7] × 10(9)/L), a platelet count of 223 × 10(9)/L (reference range, [158-424] × 10(9)/L), an alkaline phosphatase level of 85 U/L (1.42 μkat/L) (normal level, <142 U/L [2...
August 2017: Radiology
https://www.readbyqxmd.com/read/28722102/expression-of-cd34-and-cd146-vascular-markers-contributes-to-the-immunological-function-of-the-human-palatine-tonsil
#6
Marko Jović, Verica Avramović, Predrag Vlahović, Aleksandra Veličkov, Vladimir Petrović
The fundamental function of the palatine tonsil is the immune response to airborne and foodborne pathogenic agents. Small blood vessels have an important role in the provision of a special microenvironment in which the immune response occurs. In this study, we investigated the expression of vascular markers CD34 and CD146 and basal lamina marker - type IV collagen - in the small blood vessels of the human palatine tonsil in the context of their role in the immunological function of the tonsil. The tonsils were collected after tonsillectomy from ten patients with chronic tonsillitis, aged 18-28 years...
July 19, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28721147/the-importance-of-two-metabolic-syndrome-diagnostic-criteria-and-body-fat-distribution-in-predicting-clinical-severity-and-prognosis-of-acute-myocardial-infarction
#7
Marko Mornar Jelavic, Zdravko Babic, Hrvoje Pintaric
INTRODUCTION: The interrelation between metabolic syndrome (MetS) (the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF)) and obesity indices in predicting clinical severity and prognosis of acute ST-elevation myocardial infarction (STEMI) is insufficiently known. MATERIAL AND METHODS: This prospective study included 250 acute STEMI patients treated with primary percutaneous coronary intervention...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28720884/molecular-tools-for-gabaa-receptors-high-affinity-ligands-for-%C3%AE-1-containing-subtypes
#8
Xenia Simeone, David C B Siebert, Konstantina Bampali, Zdravko Varagic, Marco Treven, Sabah Rehman, Jakob Pyszkowski, Raphael Holzinger, Friederike Steudle, Petra Scholze, Marko D Mihovilovic, Michael Schnürch, Margot Ernst
γ-Aminobutyric acid type A (GABAA) receptors are pentameric GABA-gated chloride channels that are, in mammalians, drawn from a repertoire of 19 different genes, namely α1-6, β1-3, γ1-3, δ, ε, θ, π and ρ1-3. The existence of this wide variety of subunits as well as their diverse assembly into different subunit compositions result in miscellaneous receptor subtypes. In combination with the large number of known and putative allosteric binding sites, this leads to a highly complex pharmacology. Recently, a novel binding site at extracellular α+/β- interfaces was described as the site of modulatory action of several pyrazoloquinolinones...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719211/real-space-demonstration-of-induced-crystalline-3d-nanostructuration-of-organic-layers
#9
Markos Paradinas, Ana Pérez-Rodríguez, Esther Barrena, Carmen Ocal
The controlled 3D nanostructuration of molecular layers of the semiconducting molecules C22H14 (pentacene) and N, N'-dioctyl-3, 4, 9, 10-perylenetetracarboxylicdiimide (PTCDI-C8) is addressed. A tip-assisted method based using atomic force microscopy (AFM) is developed for removing the organic material and relocating it in up to five layers thick nanostructures. Moreover, unconventional molecular scale imaging combining diverse friction force microscopy modes reveals the stacking sequence of the piled layers...
July 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28718969/child-and-family-related-predictors-of-psychological-outcomes-in-children-adopted-from-abroad-what-is-the-role-of-caregiver-time
#10
Niina Rita, Marko Elovainio, Hanna Raaska, Pekka Lahti-Nuuttila, Jaakko Matomäki, Jari Sinkkonen, Helena Lapinleimu
International adoptees need to cope with stressful transitions and to develop secure attachment with their caregivers at the same time. Although most children adopted from abroad adjust fine, they are at increased risk of psychological problems. We investigated whether both child and family-related factors are associated with later psychological problems and whether the length of time spent at home after adoption before daycare moderates these associations among internationally adopted children in Finland (FinAdo, Finnish Adoption Study)...
August 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/28717916/colon-perfusion-patterns-during-colorectal-resection-using-visible-light-spectroscopy
#11
Henry Hoffmann, Tarik Delko, Philipp Kirchhoff, Rachel Rosenthal, Juliane Schäfer, Marko Kraljević, Christoph Kettelhack
BACKGROUND: The impact of blood supply to the anastomosis on development of anastomotic leakage is still a matter of debate. Considering that bowel perfusion may be affected by manipulation during surgery, perfusion assessment of the anastomosis alone may be of limited value. We propose perfusion assessment at different time points during surgery to explore the dynamics of bowel perfusion during colorectal resection and its impact on outcome. METHODS: In this prospective cohort study, patients undergoing elective colorectal resection were eligible...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28713775/salivary-tick-cystatin-omc2-targets-lysosomal-cathepsins-s-and-c-in-human-dendritic-cells
#12
Tina Zavašnik-Bergant, Robert Vidmar, Andreja Sekirnik, Marko Fonović, Jiří Salát, Lenka Grunclová, Petr Kopáček, Boris Turk
To ensure successful feeding tick saliva contains a number of inhibitory proteins that interfere with the host immune response and help to create a permissive environment for pathogen transmission. Among the potential targets of the salivary cystatins are two host cysteine proteases, cathepsin S, which is essential for antigen- and invariant chain-processing, and cathepsin C (dipeptidyl peptidase 1, DPP1), which plays a critical role in processing and activation of the granule serine proteases. Here, the effect of salivary cystatin OmC2 from Ornithodoros moubata was studied using differentiated MUTZ-3 cells as a model of immature dendritic cells of the host skin...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28713270/evaluation-of-selected-cyp51a1-polymorphisms-in-view-of-interactions-with-substrate-and-redox-partner
#13
Tadeja Režen, Iza Ogris, Marko Sever, Franci Merzel, Simona Golic Grdadolnik, Damjana Rozman
Cholesterol is essential for development, growth, and maintenance of organisms. Mutations in cholesterol biosynthetic genes are embryonic lethal and few polymorphisms have been so far associated with pathologies in humans. Previous analyses show that lanosterol 14α-demethylase (CYP51A1) from the late part of cholesterol biosynthesis has only a few missense mutations with low minor allele frequencies and low association with pathologies in humans. The aim of this study is to evaluate the role of amino acid changes in the natural missense mutations of the hCYP51A1 protein...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28712884/the-supraorbital-region-revisited-an-anatomic-exploration-of-the-neuro-vascular-bundle-with-regard-to-frontal-migraine-headache
#14
Valeria Berchtold, Hannes Stofferin, Bernhard Moriggl, Erich Brenner, Reinhard Pauzenberger, Marko Konschake
BACKGROUND: Recent findings on the pathogenesis of frontal migraine headache support, besides a central vasogenic cause, an alternative peripheral mechanism involving compressed craniofacial nerves. This is further supported by the efficiency of botulinum toxin injections as a new treatment option in frontal migraine headache patients. METHODS: The supraorbital regions of 22 alcohol-glycerine-embalmed facial halves of both sexes were dissected. Both the supratrochlear and supraorbital nerves (STN and SON, respectively) were identified, and their relationship with the corrugator supercilii muscle (CSM) was investigated by dissection and ultrasound...
June 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28712430/social-networks-and-patterns-of-health-risk-behaviours-over-two-decades-a-multi-cohort-study
#15
Maarit Kauppi, Marko Elovainio, Sari Stenholm, Marianna Virtanen, Ville Aalto, Markku Koskenvuo, Mika Kivimäki, Jussi Vahtera
OBJECTIVE: To determine the associations between social network size and subsequent long-term health behaviour patterns, as indicated by alcohol use, smoking, and physical activity. METHODS: Repeat data from up to six surveys over a 15- or 20-year follow-up were drawn from the Finnish Public Sector study (Raisio-Turku cohort, n=986; Hospital cohort, n=7307), and the Health and Social Support study (n=20,115). Social network size was determined at baseline, and health risk behaviours were assessed using repeated data from baseline and follow-up...
August 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28712091/contribution-of-genetic-factors-to-lower-dheas-in-patients-with-rheumatoid-arthritis
#16
Lucia Vernerova, Martina Mravcova, Lucia Paulikova, Miroslav Vlcek, Andrea Marko, Milada Meskova, Adela Penesova, Jozef Rovensky, Juraj Wendl, Katarina Raslova, Branislav Vohnout, Ivana Jochmanova, Ivica Lazurova, Zdenko Killinger, Guenter Steiner, Josef Smolen, Richard Imrich
OBJECTIVE: Lower production of adrenal androgens has been confirmed in females with rheumatoid arthritis (RA); however, the mechanisms of this finding are not completely understood. The aim of our study was to assess the contribution of genetic factors associated with variability of dehydroepiandrosterone sulfate (DHEAS) levels to lower DHEAS in female RA patients. METHODS: 448 RA and 648 healthy controls were genotyped for single-nucleotide polymorphisms (SNPs) in genes ZKSCAN5 (rs11761528), SULT2A1 (rs2637125), HHEX (rs2497306), and ARPC1A (rs740160)...
July 15, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28709358/analytic-solutions-throughout-a-period-doubling-route-to-chaos
#17
Marko S Milosavljevic, Jonathan N Blakely, Aubrey N Beal, Ned J Corron
We show examples of dynamical systems that can be solved analytically at any point along a period doubling route to chaos. Each system consists of a linear part oscillating about a set point and a nonlinear rule for regularly updating that set point. Previously it has been shown that such systems can be solved analytically even when the oscillations are chaotic. However, these solvable systems show few bifurcations, transitioning directly from a steady state to chaos. Here we show that a simple change to the rule for updating the set point allows for a greater variety of nonlinear dynamical phenomena, such as period doubling, while maintaining solvability...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708177/topology-optimization-of-multi-track-ring-resonators-and-2d-microcavities-for-nonlinear-frequency-conversion
#18
Zin Lin, Marko Lončar, Alejandro W Rodriguez
We exploit recently developed topology-optimization techniques to design complex, wavelength-scale resonators for enhancing various nonlinear χ<sup>(2)</sup> and χ<sup>(3)</sup> frequency conversion processes. In particular, we demonstrate aperiodic, multi-track ring resonators and two-dimensional slab microcavities exhibiting long lifetimes Q≳10<sup>4</sup>, small modal volumes V≳(λ/2n)<sup>3</sup>, and among the largest nonlinear overlaps (a generalization of phase matching in large-etalon waveguides) possible, paving the way for efficient, compact, and wide-bandwdith integrated nonlinear devices...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28708169/competition-between-raman-and-kerr-effects-in-microresonator-comb-generation
#19
Yoshitomo Okawachi, Mengjie Yu, Vivek Venkataraman, Pawel M Latawiec, Austin G Griffith, Michal Lipson, Marko Lončar, Alexander L Gaeta
We investigate the effects of Raman and Kerr gain in crystalline microresonators and determine the conditions required to generate mode-locked frequency combs. We show theoretically that a strong, narrowband Raman gain determines a maximum microresonator size allowable to achieve comb formation. We verify this condition experimentally in diamond and silicon microresonators and show that there exists a competition between Raman and Kerr effects that leads to the existence of two different comb states.
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28706977/acute-rejection-after-kidney-transplantation-associates-with-circulating-micrornas-and-vascular-injury
#20
Roel Bijkerk, Barend W Florijn, Meriem Khairoun, Jacques M G J Duijs, Gurbey Ocak, Aiko P J de Vries, Alexander F Schaapherder, Marko J K Mallat, Johan W de Fijter, Ton J Rabelink, Anton Jan van Zonneveld, Marlies E J Reinders
BACKGROUND: Acute rejection (AR) of kidney transplants is associated with the loss of endothelial integrity, microvascular rarefaction and, ultimately, graft dysfunction. Circulating angiogenic microRNAs (miRNAs) may serve as markers for microvascular injury. Here, we investigated the short- and long-term effects of AR after kidney transplantation on systemic vascular injury and the associated circulating miRNA profile. METHODS: Systemic vascular injury was determined by measuring capillary tortuosity and density within the oral mucosa as well as by assessing circulating levels of angiopoietin-2/angiopoietin-1 ratio, vascular endothelial growth factor and soluble thrombomodulin...
July 2017: Transplantation Direct
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