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https://www.readbyqxmd.com/read/28806708/predictive-simulation-of-diabetic-gait-individual-contribution-of-ankle-stiffness-and-muscle-weakening
#1
Gilmar F Santos, Aline A Gomes, Isabel C N Sacco, Marko Ackermann
Diabetic neuropathic individuals present massive muscle strength reduction at the ankle plantar- and dorsiflexors and increased joint stiffness. Our aim is to investigate the adaptation strategies to these musculoskeletal alterations during walking by means of predictive simulations. We used a seven segment planar musculoskeletal model actuated by eight Hill-type muscles in each leg. The effect of all passive tissue in muscles and other joint structures was modeled by net passive joint moment curves. The predictive simulations were generated by solving an optimal control problem that minimized a cost function, including effort and tracking terms, using direct collocation and a commercial optimal control package...
August 1, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28805645/evolutionary-feedbacks-between-insect-sociality-and-microbial-management
#2
REVIEW
Peter Hw Biedermann, Marko Rohlfs
Fitness-determining interactions with microbes-in particular fungi-have often been considered a by-product of social evolution in insects. Here, we take the view that both beneficial and harmful microbial consortia are major drivers of social behaviours in many insect systems-ranging from aggregation to eusociality. We propose evolutionary feedbacks between the insect sociality and microbial communities that strengthen mutualistic interactions with beneficial (dietary or defensive) microbes and simultaneously increase the capacity to defend against pathogens (i...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28805274/quantitative-characterization-of-galectin-3-c-affinity-mass-spectrometry-measurements-comprehensive-data-analysis-obstacles-shortcuts-and-robustness
#3
Marko Haramija, Jasna Peter-Katalinić
RATIONALE: Affinity mass spectrometry (AMS) is an emerging tool in the field of study of protein-carbohydrate complexes. However, experimental obstacles and data analysis is preventing faster integration of AMS methods in the field of glycosciences. Here we show how analysis of direct ESI-MS AMS data can be simplified for screening purposes, even for complex AMS spectra. METHODS: Direct ESI-MS assay was tested in this study, and binding data for the galectin-3C•lactose complex were analyzed using comprehensive and simplified data analysis approach...
August 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28804596/characterisation-of-tumour-derived-microvesicles-in-cancer-patients-blood-and-correlation-with-clinical-outcome
#4
Kerstin Menck, Annalen Bleckmann, Astrid Wachter, Bianca Hennies, Lena Ries, Matthias Schulz, Marko Balkenhol, Tobias Pukrop, Bawarjan Schatlo, Ulrike Rost, Dirk Wenzel, Florian Klemm, Claudia Binder
To evaluate whether tumour-derived microvesicles (T-MV), originating from the plasma membrane, represent suitable cancer biomarkers, we isolated MV from peripheral blood samples of cancer patients with locally advanced and/or metastatic solid tumours (n = 330, including 79 head & neck cancers, 74 lung cancers, 41 breast cancers, 28 colorectal cancers and 108 with other cancer forms) and controls (n = 103). Whole MV preparations were characterised using flow cytometry. While MV carrying the tumour-associated proteins MUC1, EGFR and EpCAM were found to be enhanced in a tumour-subtype-specific way in patients' blood, expression of the matrix metalloproteinase inducer EMMPRIN was increased independent of tumour type...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28801712/design-and-characterization-of-alcalase-chitosan-conjugates-as-potential-biocatalysts
#5
Milena G Žuža, Nikola Z Milašinović, Marko M Jonović, Jelena R Jovanović, Melina T Kalagasidis Krušić, Branko M Bugarski, Zorica D Knežević-Jugović
In this study, alcalase (protease from Bacillus licheniformis) immobilization by adsorption, enzyme crosslinking and covalent enzyme binding to activated chitosan microbeads were examined. The biocatalysts highest activity was obtained by covalent immobilization of alcalase onto a solid support. The alcalase covalent immobilization onto different types of chitosan beads obtained by inverse emulsion technique and electrostatic extrusion was studied. Parameters examined under different conditions were beads diameter, enzyme loading, enzyme capacity yield, and biocatalyst activity...
August 11, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28800063/fabrication-and-characterization-of-flexible-and-miniaturized-humidity-sensors-using-screen-printed-tio%C3%A2-nanoparticles-as-sensitive-layer
#6
Georges Dubourg, Apostolos Segkos, Jaroslav Katona, Marko Radović, Slavica Savić, Georgios Niarchos, Christos Tsamis, Vesna Crnojević-Bengin
This paper describes the fabrication and the characterization of an original example of a miniaturized resistive-type humidity sensor, printed on flexible substrate in a large-scale manner. The fabrication process involves laser ablation for the design of interdigitated electrodes on PET (Poly-Ethylene Terephthalate) substrate and a screen-printing process for the deposition of the sensitive material, which is based on TiO₂ nanoparticles. The laser ablation process was carefully optimized to obtain micro-scale and well-resolved electrodes on PET substrate...
August 11, 2017: Sensors
https://www.readbyqxmd.com/read/28799690/fluid-driven-interfacial-instabilities-and-turbulence-in-bacterial-biofilms
#7
Stefania Fabbri, Jian Li, Robert P Howlin, Amir Rmaile, Bart Gottenbos, Marko De Jager, E Michelle Starke, Marcelo Aspiras, Marilyn T Ward, Nick G Cogan, Paul Stoodley
Biofilms are thin layers of bacteria embedded within a slime matrix that live on surfaces. They are ubiquitous in nature and responsible for many medical and dental infections, industrial fouling and are also evident in ancient fossils. A biofilm structure is shaped by growth, detachment and response to mechanical forces acting on them. The main contribution to biofilm versatility in response to physical forces is the matrix that provides a platform for the bacteria to grow. The interaction between biofilm structure and hydrodynamics remains a fundamental question concerning biofilm dynamics...
August 11, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28798921/screening-of-celiac-disease-in-down-syndrome-old-and-new-dilemmas
#8
REVIEW
Momcilo Pavlovic, Karolina Berenji, Marko Bukurov
Celiac disease (CD) is a common and well defined autoimmune disorder caused by gliadin and related proteins of wheat, rye, and barley. Epidemiologic studies confirmed that CD is highly associated with other autoimmune diseases and with Down syndrome (DS). The symptomatic form of CD in patients with DS is more frequent than asymptomatic forms. However, growth impairment, anemia, intermittent diarrhea, and constipation are symptoms and signs typically of children with DS without CD. Late identification of the disease can lead to various complications, sometimes even very severe...
July 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28798351/snap-25b-deficiency-increases-insulin-secretion-and-changes-spatiotemporal-profile-of-ca-2-oscillations-in-%C3%AE-cell-networks
#9
Teresa Daraio, Lidija Križančić Bombek, Marko Gosak, Ismael Valladolid-Acebes, Maša Skelin Klemen, Essam Refai, Per-Olof Berggren, Kerstin Brismar, Marjan Slak Rupnik, Christina Bark
SNAP-25 is a protein of the core SNARE complex mediating stimulus-dependent release of insulin from pancreatic β cells. The protein exists as two alternatively spliced isoforms, SNAP-25a and SNAP-25b, differing in 9 out of 206 amino acids, yet their specific roles in pancreatic β cells remain unclear. We explored the effect of SNAP-25b-deficiency on glucose-stimulated insulin release in islets and found increased secretion both in vivo and in vitro. However, slow photo-release of caged Ca(2+) in β cells within pancreatic slices showed no significant differences in Ca(2+)-sensitivity, amplitude or rate of exocytosis between SNAP-25b-deficient and wild-type littermates...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795847/successful-containment-of-the-first-kpc-producing-klebsiella-pneumoniae-outbreak-in-croatia
#10
Dijana Varda Brkic, Irina Pristas, Ivan Cipris, Marko Jelic, Iva Butic, Arjana Tambic Andrasevic
AIM: We report the first outbreak caused by Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae sequence type 258 (ST 258) clone that occurred in Croatia from May to December 2012. MATERIALS & METHODS: 23 carbapenem-resistant K. pneumoniae isolates were recovered from clinical and screening specimens of 12 patients hospitalized in a regional hospital. The first isolates from the 12 patients were typed using pulsed-field gel electrophoresis and multilocus sequence typing...
August 10, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28794636/helicobacter-pylori-infection-and-severity-of-coronary-atherosclerosis-in-patients-with-chronic-coronary-artery-disease
#11
Anita Jukic, Dorotea Bozic, Dusko Kardum, Tina Becic, Bruno Luksic, Mislav Vrsalovic, Marko Ljubkovic, Damir Fabijanic
AIM: Controversy exists concerning the relation between Helicobacter pylori (HP) infection and coronary artery disease (CAD). We aimed to examine the relationship between HP infection and severity of coronary atherosclerosis in patients with chronic CAD. PATIENTS AND METHODS: A total of 150 patients (109 [73%] men; mean age 62.61±10.23 years) scheduled for coronary artery bypass grafting surgery were consecutively enrolled in the cross-sectional study. According to rapid urease test and/or gastric biopsy samples stained with hematoxylin and eosin and according to Giemsa, patients were classified as HP positive (n=87; 58%) or HP negative (n=63; 42%)...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28793355/effects-of-cannabidiol-on-morphine-conditioned-place-preference-in-mice
#12
James Roland Markos, Hannah M Harris, Waseem Gul, Mahmoud A ElSohly, Kenneth J Sufka
This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties...
August 9, 2017: Planta Medica
https://www.readbyqxmd.com/read/28790144/impact-of-physician-navigators-on-productivity-indicators-in-the-ed
#13
Alexander K Leung, Gaurav Puri, Bingshu E Chen, Zhenxian Gong, Eddie Chan, Edward Feng, Marko Duic
OBJECTIVES: We created Physician Navigators in our ED to help improve emergency physician (EP) productivity. We aimed to quantify the effect of Physician Navigators on measures of EP productivity: patient seen per hour (Pt/hr), and turn-around time (TAT) to discharge. Secondary objectives included examining their impact on measures of ED throughput for non-resuscitative patients: ED length of stay (LOS), door-to-physician time and left-without-being-seen rates (LWBS). METHODS: In this retrospective study, 6845 clinical shifts worked by 20 EPs at a community ED in Newmarket, Canada from 1 January 2012 to 31 March 2015 were evaluated...
August 8, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28789794/does-high-optimism-protect-against-the-inter-generational-transmission-of-high-bmi-the-cardiovascular-risk-in-young-finns-study
#14
Anna Serlachius, Laura Pulkki-Råback, Markus Juonala, Matthew Sabin, Terho Lehtimäki, Olli Raitakari, Marko Elovainio
OBJECTIVE: The transmission of overweight from one generation to the next is well established, however little is known about what psychosocial factors may protect against this familial risk. The aim of this study was to examine whether optimism plays a role in the intergenerational transmission of obesity. METHODS: Our sample included 1043 participants from the prospective Cardiovascular Risk in Young FINNS Study. Optimism was measured in early adulthood (2001) when the cohort was aged 24-39years...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28780491/health-impact-modelling-of-different-travel-patterns-on-physical-activity-air-pollution-and-road-injuries-for-s%C3%A3-o-paulo-brazil
#15
Thiago Hérick de Sá, Marko Tainio, Anna Goodman, Phil Edwards, Andy Haines, Nelson Gouveia, Carlos Monteiro, James Woodcock
BACKGROUND: São Paulo city, Brazil, faces challenges caused by rapid urbanization. We illustrate how future travel patterns could lead to different health consequences in the city. METHODS: We evaluated the health impacts of different travel pattern scenarios for the São Paulo adult population by comparing the travel patterns of São Paulo in 2012 with counterfactual scenarios in which the city adopted travel patterns of i) those living in the city's expanded centre; ii) London (2012); iii) a highly motorized São Paulo (SP California); and iv) a visionary São Paulo (SP 2040), with high levels of walking and cycling and low levels of car and motorcycle use...
August 3, 2017: Environment International
https://www.readbyqxmd.com/read/28778044/role-of-phenolic-compounds-during-antioxidative-responses-of-winter-triticale-to-aphid-and-beetle-attack
#16
Paweł Czerniewicz, Hubert Sytykiewicz, Roma Durak, Beata Borowiak-Sobkowiak, Grzegorz Chrzanowski
One of the earliest responses of plants to insects' attack is generation of reactive oxygen species. However, the elevated level of ROS can elicit oxidative burst within plant tissues, and plants employ antioxidant systems against these radicals. Due to their chemical structures, polyphenols are able to diminish the level of ROS. Thus, we investigated the role of phenolic compounds in oxidative stress within winter triticale caused by Sitobion avenae and Oulema melanopus. It was found, that infestation by insects induced a high increase in the content of hydrogen peroxide and superoxide anion radical within resistant Lamberto cv...
July 29, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28777835/effect-of-methotrexate-on-an-in-vitro-patient-derived-model-of-proliferative-vitreoretinopathy
#17
Dhanesh Amarnani, Arturo Israel Machuca-Parra, Lindsay L Wong, Christina K Marko, James A Stefater, Tomasz P Stryjewski, Dean Eliott, Joseph F Arboleda-Velasquez, Leo A Kim
Purpose: The purpose of this study was to develop a method for isolating, culturing, and characterizing cells from patient-derived membranes in proliferative vitreoretinopathy (PVR) to be used for drug testing. Methods: PVR membranes were obtained from six patients with grade C PVR. Membrane fragments were analyzed by gross evaluation, fixed for immunohistologic studies to establish cell identity, or digested with collagenase II to obtain single cell suspensions for culture...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28777570/in-situ-scrutiny-of-the-relationship-between-polymorphic-phases-and-properties-of-self-assembled-monolayers-of-a-biphenyl-based-thiol
#18
Markos Paradinas, Carmen Munuera, Manfred Buck, Carmen Ocal
Two polymorphic phases of ω-(4'-methylbiphenyl-4-yl) butane-1-thiol (BP4) molecules formed on Au(111) were investigated by multi-dimensional atomic force microscopy, combining conductivity measurements, electrostatic characterization, friction force mapping and normal force spectroscopy. Based on the same molecular structure but differing in molecular order, packing density and molecular tilt, the two phases serve as a test bench to establish the structure-property relationships in self-assembled monolayers (SAMs)...
August 4, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28772749/analysis-of-the-mechanical-behavior-creep-resistance-and-uniaxial-fatigue-strength-of-martensitic-steel-x46cr13
#19
Josip Brnic, Sanjin Krscanski, Domagoj Lanc, Marino Brcic, Goran Turkalj, Marko Canadija, Jitai Niu
The article deals with the analysis of the mechanical behavior at different temperatures, uniaxial creep and uniaxial fatigue of martensitic steel X46Cr13 (1.4034, AISI 420). For the purpose of considering the aforementioned mechanical behavior, as well as determining the appropriate resistance to creep and fatigue strength levels, numerous uniaxial tests were carried out. Tests related to mechanical properties performed at different temperatures are presented in the form of engineering stress-strain diagrams...
April 6, 2017: Materials
https://www.readbyqxmd.com/read/28772719/mineral-based-coating-of-plasma-treated-carbon-fibre-rovings-for-carbon-concrete-composites-with-enhanced-mechanical-performance
#20
Kai Schneider, Matthias Lieboldt, Marco Liebscher, Maik Fröhlich, Simone Hempel, Marko Butler, Christof Schröfl, Viktor Mechtcherine
Surfaces of carbon fibre roving were modified by means of a low temperature plasma treatment to improve their bonding with mineral fines; the latter serving as an inorganic fibre coating for the improved mechanical performance of carbon reinforcement in concrete matrices. Variation of the plasma conditions, such as gas composition and treatment time, was accomplished to establish polar groups on the carbon fibres prior to contact with the suspension of mineral particles in water. Subsequently, the rovings were implemented in a fine concrete matrix and their pull-out performance was assessed...
March 29, 2017: Materials
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