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https://www.readbyqxmd.com/read/29458126/structural-and-mechanistic-analysis-of-the-choline-sulfatase-from-sinorhizobium-melliloti-a-class-i-sulfatase-specific-for-an-alkyl-sulfate-ester
#1
Bert van Loo, Markus Schober, Eugene Valkov, Magdalena Heberlein, Erich Bornberg-Bauer, Kurt Faber, Marko Hyvönen, Florian Hollfelder
Hydrolysis of organic sulfate esters proceeds by two distinct mechanisms, water attacking at either sulfur (S-O bond cleavage) or carbon (C-O bond cleavage). In primary and secondary alkyl sulfates attack at carbon is favored, whereas in aromatic sulfates and sulfated sugars attack at sulfur is preferred. This mechanistic distinction is mirrored in the classification of enzymes that catalyze sulfate ester hydrolysis: arylsulfatases catalyze S-O cleavage in sulfate sugars and arylsulfates and alkyl sulfatases break the C-O bond of alkyl sulfates...
February 16, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29458068/ovarian-microcystic-stromal-tumor-with-undetermined-potential-case-study-with-molecular-analysis-and-literature-review
#2
Ying Zhang, Lin Tao, Can Yin, Weiwei Wang, Hong Zou, Yan Ren, Weihua Liang, Jinfang Jiang, Wenjie Zhang, Wei Jia, Feng Li
Ovarian microcystic stromal tumor is a relatively rare tumor type. This tumor is characterized by a unique microcyst structure and essentially all tumors show benign biological behavior. Here, we report a case with a primary ovarian microcystic stromal tumor that experienced recurrence. Pathological findings showed that the original tumor, relapsed tumor in the ovary, and the recurrent tumor in the iliac fossa presented similar histological features. The tumor mainly consisted of microcysts, solid cellular regions, and a fibrous stroma...
February 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29457916/systematic-review-of-psychiatric-signs-in-niemann-pick-disease-type-c
#3
Olivier Bonnot, Hans-Hermann Klünemann, Christian Velten, Juan Vicente Torres Martin, Mark Walterfang
OBJECTIVES: We conducted the first systematic literature review and analysis of psychiatric manifestations in Niemann-Pick disease type C (NPC) to describe: 1) time of occurrence of psychiatric manifestations relative to other disease manifestations; 2) frequent combinations of psychiatric, neurological and visceral disease manifestations. METHODS: A systematic EMBase literature search was conducted to identify, collate and analyze published data from patients with NPC associated with psychiatric symptoms, published between January 1967 and November 2015...
February 19, 2018: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/29457910/mechanistic-analysis-of-ion-association-between-dendrigraft-poly-l-lysine-and-8-anilino-1-naphthalenesulfonate-at-liquid-liquid-interfaces
#4
Hirohisa Nagatani, Masataka Fujisawa, Hisanori Imura
Molecular association between biocompatible dendritic polymers, dendrigraft poly-L-lysines (DGLs), and an anionic fluorescent probe, 8-anilino-1-naphthalenesulfonate (ANS- ), was studied at the polarized water|1,2-dichloroethane (DCE) interface. The fluorescence intensity of ANS measured in aqueous solution was enhanced by the coexistence of DGL over a wide pH range (2 < pH < 10), where ANS and DGL exist as a monoanionic form and polycation, respectively. The voltammetric responses indicated that the positively charged DGL was adsorbed at the water|DCE interface, while ANS- was transferred across the interface accompanied by the adsorption process...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29457893/kinetics-thermodynamics-and-mechanism-of-a-novel-biphasic-solvent-for-co2-capture-from-flue-gas
#5
Shihan Zhang, Yao Shen, Peijing Shao, Jianmeng Chen, Lidong Wang
The main issue related to the deployment of amine-based absorption process for CO2 capture from flue gas is its intensive energy penalty. Therefore, this study screened a novel biphasic solvent, comprising a primary amine e.g., triethylenetetramine (TETA) and a tertiary amine e.g., N, N-dimethylcyclohexylamine (DMCA), to reduce the energy consumption. The TETA-DMCA blend exhibited high cyclic capacity of CO2 absorption, favorable phase separation behavior, and low regeneration heat. Kinetic analysis showed that the gas- and liquid-side mass transfer resistances were comparable in the lean solution of TETA-DMCA at 40oC, whereas the liquid-side mass transfer resistance became dominant in the rich solution...
February 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29457646/a-reexamination-of-the-cognitive-behavioral-model-of-chronic-fatigue-syndrome
#6
Madison Sunnquist, Leonard A Jason
OBJECTIVE: The cognitive behavioral model of chronic fatigue syndrome (CFS) suggests that cognitions and reduced activity level perpetuate the fatigue and impairment that individuals with CFS experience. The two empirical evaluations of this model resulted in conflicting findings. The current study examines the influence of case definition fulfillment on the applicability of this model to CFS. METHOD: A moderated mediation analysis was conducted on 990 individuals with CFS to reexamine the behavioral pathway of this model...
February 19, 2018: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29457631/non-invasive-genetic-censusing-and-monitoring-of-primate-populations
#7
REVIEW
Mimi Arandjelovic, Linda Vigilant
Knowing the density or abundance of primate populations is essential for their conservation management and contextualizing socio-demographic and behavioral observations. When direct counts of animals are not possible, genetic analysis of non-invasive samples collected from wildlife populations allows estimates of population size with higher accuracy and precision than is possible using indirect signs. Furthermore, in contrast to traditional indirect survey methods, prolonged or periodic genetic sampling across months or years enables inference of group membership, movement, dynamics, and some kin relationships...
February 19, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29457598/in-vivo-biocompatibility-and-degradation-of-novel-polycaprolactone-biphasic-calcium-phosphate-scaffolds-used-as-a-bone-substitute
#8
Nuttawut Thuaksuban, Rungrot Pannak, Pleumjit Boonyaphiphat, Naruporn Monmaturapoj
BACKGROUND: Biocompatibility and degradation of poly ε-caprolactone (PCL)-Biphasic Calcium Phosphate (BCP) scaffolds fabricated by the "Melt Stretching and Compression Molding (MSCM)" technique were evaluated in rat models. OBJECTIVES: Degradation behaviors and histological biocompatibility of the PCL-20% BCP MSCM scaffolds and compare with those of PCL-20% β-tricalcium phosphate (TCP) scaffolds commercially fabricated by Fused Deposition Modeling (FDM) were evaluated...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457593/characterization-study-and-optimization-of-swelling-behavior-for-p-hema-co-eudragit-l-100-hydrogels-by-using-taguchi-method
#9
Hediye Irem Ozgunduz, Abdullah Bilal Ozturk, Hava Gizem Kandilci, Nil Acarali
The aim of this study is to produce the smart hydrogel to use insulin release for human body. p(HEMA-co-Eudragit L-100) hydrogels containing different ratios of 2-Hydroxyethyl methacrylate (HEMA) and Eudragait L-100 were synthesized by using ammonium persulfate (APS) as an initiator and ethylene glycol dimethacrylate (EGDMA) as a cross linker. The structures of hydrogels produced were characterized by using Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning electron microscope (SEM) analysis. In this way, optimum synthesis conditions were determined for p(HEMA-co-Eudragit L-100) hydrogels by using Taguchi method as an optimization method...
2018: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/29457520/caregiver-reactions-to-aggressive-behaviors-in-persons-with-dementia-in-a-diverse-community-dwelling-sample
#10
Bryan R Hansen, Nancy A Hodgson, Chakra Budhathoki, Laura N Gitlin
PURPOSE: To describe caregiver challenges with and confidence managing three aggressive behavior types in persons with dementia: verbal aggression, destroying property, and threatening to hurt others. DESIGN AND METHOD: Secondary analysis of baseline data from the 2001-2004 Resources for Enhancing Alzheimer's Caregiver Health II (REACH II) initiative. RESULTS: One or more aggressive behaviors within 1 week were reported by more than a third of caregivers, with most expressing upset but fewer expressing confidence managing the behaviors...
February 1, 2018: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29457232/tackling-obesity-and-disease-the-culprit-is-sugar-the-response-is-legal-regulation
#11
Lawrence O Gostin
It is staggering to observe the new normal in America: 37.9 percent of adults are obese, and 70.7 percent are either obese or overweight. One out of every five minors is obese. The real tragedy, of course, is the disability, suffering, and early death that devastates families and communities. But all of society pays, with the annual medical cost estimated at $147 billion. The causal pathways are complex, but if we drill down, sugar is a deeply consequential pathway to obesity, and the single greatest dietary source is sugar-sweetened beverages (SSBs)...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29457125/enhanced-differentiation-of-dental-pulp-cells-cultured-on-microtubular-polymer-scaffolds-in-vitro
#12
Morteza Haeri, Karen Sagomonyants, Mina Mina, Liisa T Kuhn, A Jon Goldberg
Dental caries (tooth decay) is the most common chronic disease. Dental tissue engineering is a promising alternative approach to alleviate the shortcomings of the currently available restorative materials. Mimicking the natural extracellular matrix (ECM) could enhance the performance of tissue engineering scaffolds. In this study, we developed microtubular (~20 μm diameter) polymethyl methacrylate (PMMA) scaffolds resembling the tubular (~2.5 μm diameter) structure of dentin, the collagen-based mineralized tissue that forms the major portion of teeth, to study the effect of scaffold architecture on differentiation of mouse dental pulp cells in vitro ...
June 2017: Regenerative Engineering and Translational Medicine
https://www.readbyqxmd.com/read/29456984/the-efficacy-of-internet-based-cognitive-behavioral-therapy-on-the-anxiety-disorders-among-adolescent-girls
#13
Afsaneh Karbasi, Azadeh Haratian
Background: The prevalence of anxiety disorders among children and adolescents are found to be approximately between 8-12 and 5-10, respectively, and the long-lasting effects of such disorders can expose the sufferers to impairment and dysfunction in several areas of life the examples of which are poor educational performance, low self-esteem, and depression. The present study aims to evaluate the efficacy of internet-based, cognitive-behavioral therapy (ICBT) in treating the anxiety disorders among adolescent females...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29456906/health-communication-experiences-of-emerging-adults-with-type-1-diabetes
#14
MaryJane Simms, Katherine Baumann, Maureen Monaghan
Objective: In an effort to refine a model of clinical care identifying effective communication with health care providers (HCPs) as a key skill for successful transition to adult medical care, this study explored the perspectives of emerging adults with type 1 diabetes (T1D) about factors that impact the quality and content of communication with their HCPs. Methods: Twenty emerging adults with T1D were interviewed about health communication experiences with their pediatric HCP and readiness for transition to adult diabetes care...
December 2017: Clinical Practice in Pediatric Psychology
https://www.readbyqxmd.com/read/29456845/low-carbonyl-reductase-1-expression-is-associated-with-poor-prognosis-in-patients-with-oral-squamous-cell-carcinoma
#15
Ryota Yamanouchi, Koji Harada, Tarannum Ferdous, Yoshiya Ueyama
Carbonyl reductase 1 (CBR1) is an enzyme that catalyzes the reduction of numerous compounds by using NADPH-dependent oxidoreductase activity. Decreased expression of CBR1 is associated with disease progression and an unfavorable outcome in several types of malignancies. The purpose of the current study was to determine whether CBR1 expression could be a useful prognostic factor in patients with oral squamous cell carcinoma (OSCC). Therefore, its mechanisms of action were investigated in order to understand how CBR1 affects cancer cell behavior in vitro ...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29456525/kinetics-and-novel-degradation-pathway-of-permethrin-in-acinetobacter-baumannii-zh-14
#16
Hui Zhan, Huishan Wang, Lisheng Liao, Yanmei Feng, Xinghui Fan, Lianhui Zhang, Shaohua Chen
Persistent use of permethrin has resulted in its ubiquitous presence as a contaminant in surface streams and soils, yet little is known about the kinetics and metabolic behaviors of this pesticide. In this study, a novel bacterial strain Acinetobacter baumannii ZH-14 utilizing permethrin via partial hydrolysis pathways was isolated from sewage sludge. Response surface methodology based on Box-Behnken design of cultural conditions was used for optimization resulting in 100% degradation of permethrin (50 mg·L-1 ) within 72 h...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29456524/-saccharomyces-cerevisiae-and-s-kudriavzevii-synthetic-wine-fermentation-performance-dissected-by-predictive-modeling
#17
David Henriques, Javier Alonso-Del-Real, Amparo Querol, Eva Balsa-Canto
Wineries face unprecedented challenges due to new market demands and climate change effects on wine quality. New yeast starters including non-conventional Saccharomyces species, such as S. kudriavzevii , may contribute to deal with some of these challenges. The design of new fermentations using non-conventional yeasts requires an improved understanding of the physiology and metabolism of these cells. Dynamic modeling brings the potential of exploring the most relevant mechanisms and designing optimal processes more systematically...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29456279/uncertainty-footprint-visualization-of-nonuniform-behavior-of-iterative-algorithms-applied-to-4d-cell-tracking
#18
Y Wan, C Hansen
Research on microscopy data from developing biological samples usually requires tracking individual cells over time. When cells are three-dimensionally and densely packed in a time-dependent scan of volumes, tracking results can become unreliable and uncertain. Not only are cell segmentation results often inaccurate to start with, but it also lacks a simple method to evaluate the tracking outcome. Previous cell tracking methods have been validated against benchmark data from real scans or artificial data, whose ground truth results are established by manual work or simulation...
June 2017: Computer Graphics Forum: Journal of the European Association for Computer Graphics
https://www.readbyqxmd.com/read/29456133/no-evidence-for-systematic-white-matter-correlates-of-dyslexia-an-activation-likelihood-estimation-meta-analysis
#19
David Moreau, Josephine E Stonyer, Nicole S McKay, Karen E Waldie
Dyslexia is a prevalent neurodevelopmental disorder, characterized by reading and spelling difficulties. Beyond the behavioral and functional correlates of this condition, a growing number of studies have explored structural differences between individuals with dyslexia and typically developing individuals. To date, findings remain disparate - some studies suggest differences in fractional anisotropy (FA), an indirect measure of white matter integrity, whereas others do not identify significant disparities...
March 15, 2018: Brain Research
https://www.readbyqxmd.com/read/29456012/injectable-and-body-temperature-sensitive-hydrogels-based-on-chitosan-and-hyaluronic-acid-for-ph-sensitive-drug-release
#20
Wei Zhang, Xin Jin, Heng Li, Run-Run Zhang, Cheng-Wei Wu
Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer cell. The drug (doxorubicin) loaded hydrogel precursor solutions are injectable and turn to hydrogels when the temperature is increased to body temperature. The acidic condition (pH 4.00) can trigger the release of drug and the cancer cell (Hela) can adhere to the surface of the hydrogels, which will be beneficial for tumor site-specific administration of drug...
April 15, 2018: Carbohydrate Polymers
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