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https://www.readbyqxmd.com/read/28830033/quartz-crystal-microbalance-sensing-cell-substrate-adhesion-and-beyond
#1
REVIEW
Jennifer Y Chen, Lynn S Penn, Jun Xi
Cell adhesion is an essential aspect of cellular behavior. Finding innovative methods to probe the adhesion of cells in their native state can greatly advance the understanding of control and regulation of cellular behavior and their impact on human health. The quartz crystal microbalance (QCM) is a label-free, biosensing system that has, in the past fifty years, evolved from a simple acoustic based mass sensor to a powerful bioanalytical tool. Its unique capability of monitoring the cell-substrate interaction non-invasively in real time has led to the emergence of its applications in areas that are relevant to fundamental cell biology and medical research...
August 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28830031/perampanel-with-concomitant-levetiracetam-and-topiramate-post-hoc-analysis-of-adverse-events-related-to-hostility-and-aggression
#2
Steve Chung, Betsy Williams, Cindy Dobrinsky, Anna Patten, Haichen Yang, Antonio Laurenza
In 4 Phase III registration trials (3 in patients with partial seizures, N=1480; 1 in patients with PGTCS, N=163), perampanel administered to patients already receiving 1-3 concomitant antiepileptic drugs (AEDs) demonstrated statistically superior efficacy compared to placebo in reducing seizure frequency. However, use of perampanel in these studies was associated with a risk of psychiatric and behavioral adverse reactions, including aggression, hostility, irritability, anger, and homicidal ideation and threats...
August 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28830026/progesterone-therapy-induces-an-m1-to-m2-switch-in-microglia-phenotype-and-suppresses-nlrp3-inflammasome-in-a-cuprizone-induced-demyelination-mouse-model
#3
Roya Aryanpour, Parichehr Pasbakhsh, Kazem Zibara, Zeinab Namjoo, Fatemeh Beigi Boroujeni, Saeed Shahbeigi, Iraj Ragerdi Kashani, Cordian Beyer, Adib Zendehdel
Demyelination of the central nervous system (CNS) has been associated to reactive microglia in neurodegenerative disorders, such as multiple sclerosis (MS). The M1 microglia phenotype plays a pro-inflammatory role while M2 is involved in anti-inflammatory processes in the brain. In this study, CPZ-induced demyelination mouse model was used to investigate the effect of progesterone (PRO) therapy on microglia activation and neuro-inflammation. Results showed that progesterone therapy (CPZ+PRO) decreased neurological behavioral deficits, as demonstrated by significantly decreased escape latencies, in comparison to CPZ mice...
August 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28829935/extensive-assessment-of-the-physical-mechanical-and-adhesion-behavior-of-a-low-viscosity-bulk-fill-composite-and-a-traditional-resin-composite-in-tooth-cavities
#4
R X Sousa-Lima, Lja Silva, Lvf Chaves, S Geraldeli, Rcb Alonso, Bcd Borges
OBJECTIVES: To compare the degree of conversion (DC), depth of polymerization (DP), shrinkage stress (SS), flexural strength (FS), elastic modulus (EM), and bond strength (BS) of a low-viscosity bulk fill resin composite and a paste-like traditional composite. METHODS: Tetric Evo-Flow Bulk Fill (TBF) and Empress Direct (ED; Ivoclar Vivadent) composites were used. DC (%) and FS/EM (MPa/GPa) were evaluated in bar specimens (7×2×1 mm; n=10) using Fourier-transform infrared spectroscopy and a three-point bending test in a universal testing machine (UTM), respectively...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28829903/stability-and-adaptability-of-soybean-cultivars-in-minas-gerais
#5
I O Soares, A T Bruzi, E V Zambiazzi, S R Guilherme, M C Bianchi, K B Silva, V Fronza, C M Teixeira
Genotypes x environment (G x E) interaction consists of different behavior of genotypes cultivated in different environments. This interaction occurs due to the performance variation of each genotype in different environments. To reduce the effect of the interaction in soybean crops, some studies have been reported in the literature to study their adaptability and stability. However, these studies are still scarce in Minas Gerais State. Thus, the aim of this study was to verify the adaptability and stability of soybean cultivars and identify the cultivars that contribute least to the G x E interaction in Minas Gerais...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829891/physiological-and-enzymatic-alterations-in-sesame-seeds-submitted-to-different-osmotic-potentials
#6
R M O Pires, M A B Àvila, D G Leite, H O Santos, G A Souza, E V R Von Pinho
With the imminence of global climate changes that affect the temperature and the rainfall uniformity, it is growing the concern about the adaptation of crops to the water deficit. Thus, the objective of this study was to evaluate alterations in physiological and enzymatic mechanisms during the germination process of sesame seeds under different water availability. To simulate the water restriction we used PEG6000, a high molecular weight molecule that does not penetrate the seed structure but allows different osmotic potentials...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829812/use-of-traditional-eye-medicine-and-self-medication-in-rural-india-a-population-based-study
#7
Noopur Gupta, Praveen Vashist, Radhika Tandon, Sanjeev K Gupta, Mani Kalaivani, S N Dwivedi
OBJECTIVE: To determine the type and nature of traditional eye medicine (TEM), their sources and use and practices related to self-medication for ophthalmic diseases in a rural Indian population. METHODS: A population-based, cross-sectional study was conducted in 25 randomly selected clusters of Rural Gurgaon, Haryana, India as part of CORE (Cornea Opacity Rural Epidemiological) study. In addition to comprehensive ophthalmic examination, health-seeking behavior and use of self-medication and TEM was assessed in the adult population using a semi-structured questionnaire...
2017: PloS One
https://www.readbyqxmd.com/read/28829689/theoretical-and-experimental-investigations-of-mercury-adsorption-on-hematite-surfaces
#8
Ji-Eun Jung, Simona Liguori, Adam D Jew, Gordon E Brown, Jennifer Wilcox
One of the biggest environmental concerns caused by coal-fired power plants is the emission of mercury (Hg), which is toxic metal. To control the emission of Hg from coal-derived flue gas, it is important to understand the behavior, speciation of Hg as well as the interaction between Hg and solid materials in the flue gas stream. In this study, atomic-scale theoretical investigations using density functional theory (DFT) were carried out in conjunction with lab-scale experimental studies to investigate the adsorption behavior of Hg on hematite (?-Fe2O3)...
August 22, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28829397/precision-nutrition-a-review-of-personalized-nutritional-approaches-for-the-prevention-and-management-of-metabolic-syndrome
#9
REVIEW
Juan de Toro-Martín, Benoit J Arsenault, Jean-Pierre Després, Marie-Claude Vohl
The translation of the growing increase of findings emerging from basic nutritional science into meaningful and clinically relevant dietary advices represents nowadays one of the main challenges of clinical nutrition. From nutrigenomics to deep phenotyping, many factors need to be taken into account in designing personalized and unbiased nutritional solutions for individuals or population sub-groups. Likewise, a concerted effort among basic, clinical scientists and health professionals will be needed to establish a comprehensive framework allowing the implementation of these new findings at the population level...
August 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28829389/-you-think-you-re-helping-them-but-they-re-helping-you-too-experiences-of-scottish-male-young-offenders-participating-in-a-dog-training-program
#10
Rebecca J Leonardi, Hannah M Buchanan-Smith, Gill McIvor, Sarah-Jane Vick
Interaction with animals can be beneficial to humans and animal-assisted interventions (AAIs) are increasingly popular in a range of contexts. Dog training programs (DTPs) are the most popular form of AAI in custodial contexts; prisoners often have multiple needs and DTPs seem to facilitate a diverse range of positive outcomes, including improvements in well-being, behavior, and offending behavior. However, evidence on the efficacy of prison-based DTPs is still limited and these evaluations often lack detail or methodological rigor...
August 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28829238/guideposts-and-roadblocks-to-the-career-long-scholarly-engagement-of-physical-education-teacher-education-faculty
#11
Catherine P Berei, Erica Pratt, Melissa Parker, Kevin Shephard, Tanjian Liang, Udon Nampai, Guntima Neamphoka
PURPOSE: Scholarship is essential for the growth and development of the physical education field. Over time, scholarship expectations have changed, forcing faculty members to alter time spent for research, teaching, and service. Social-cognitive career theory (SCCT) presents a model for understanding performance and persistence in an occupational environment. The interconnected aspects of SCCT have different emphasis related to self-efficacy, outcome expectations, or personal goals pursuit...
August 22, 2017: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/28829005/does-working-with-the-veder-contact-method-influence-the-job-satisfaction-of-caregivers-a-non-randomized-controlled-trial-in-nursing-homes-for-people-with-dementia
#12
P Boersma, R M Dröes, B I Lissenberg-Witte, B van Meijel, J C M van Weert
BACKGROUND: Person-centered care interventions can improve the quality of life and decrease behavioral problems of people with dementia. Although not convincingly proven, person-centered care interventions may benefit the caregivers as well. This study aims to gain insight into how working with the Veder Contact Method (VCM) - a new person-centered care method - influences the job satisfaction of caregivers. METHODS: Within a quasi-experimental study, the job satisfaction of caregivers of six experimental wards (n = 75) was compared with caregivers of six control wards (n = 36) that applied Care-As-Usual...
August 22, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28828937/development-and-psychometric-testing-of-the-diabetes-caregiver-activity-and-support-scale
#13
Lisa J Scarton, Tamilyn Bakas, Wendy R Miller, Susan M McLennon, Lesa L Huber, Margie A Hull
Purpose The purpose of this study was to develop and psychometrically test the Diabetes Caregiver Activity and Support Scale (D-CASS), a measure of how difficult or easy caregiver activity and supportive behaviors are for family caregivers of persons with type 2 diabetes (T2DM). Methods Internal consistency reliability, test-retest reliability, criterion-related validity, and construct validity were examined in 101 family caregivers of persons with T2DM. Participants were recruited using study brochures distributed at a large hospital in the Midwest and at statewide American Indian Pow Wows...
August 1, 2017: Diabetes Educator
https://www.readbyqxmd.com/read/28828430/giant-magnetoresistance-and-perfect-spin-filter-effects-in-manganese-phthalocyanine-based-molecular-junctions
#14
L L Tao, J Wang
The spin-filter transport and magnetoresistance effects are of particular interest in the field of molecular spintronics. In this work, based on first-principles quantum transport calculations, we report on the spin-dependent transport properties of a molecular junction made of two manganese phthalocyanine (MnPc) molecules linked by single-walled carbon nanotubes. Owing to the half-metallicity of MnPc around the Fermi energy, a perfect spin-filter effect and a giant magnetoresistance effect are observed in the molecular junction...
August 22, 2017: Nanoscale
https://www.readbyqxmd.com/read/28828210/short-and-long-term-antidepressant-effects-of-ketamine-in-a-rat-chronic-unpredictable-stress-model
#15
Yinghong Jiang, Yiqiang Wang, Xiaoran Sun, Bo Lian, Hongwei Sun, Gang Wang, Zhongde Du, Qi Li, Lin Sun
OBJECTIVE: This research was aimed to evaluate the behaviors of short- or long-term antidepressant effects of ketamine in rats exposed to chronic unpredictable stress (CUS). BACKGROUND: Ketamine, a glutamate noncompetitive NMDA receptor antagonist, regulates excitatory amino acid functions, such as anxiety disorders and major depression, and plays an important role in synaptic plasticity and learning and memory. METHODS: After 42 days of CUS model, male rats received either a single injection of ketamine (10 mg/kg; day 43) or 15 daily injections (days 43-75)...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28828204/imaging-gait-analysis-an-fmri-dual-task-study
#16
Céline N Bürki, Stephanie A Bridenbaugh, Julia Reinhardt, Christoph Stippich, Reto W Kressig, Maria Blatow
INTRODUCTION: In geriatric clinical diagnostics, gait analysis with cognitive-motor dual tasking is used to predict fall risk and cognitive decline. To date, the neural correlates of cognitive-motor dual tasking processes are not fully understood. To investigate these underlying neural mechanisms, we designed an fMRI paradigm to reproduce the gait analysis. METHODS: We tested the fMRI paradigm's feasibility in a substudy with fifteen young adults and assessed 31 healthy older adults in the main study...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28827965/ameliorative-effect-of-curcumin-on-olanzapine-induced-obesity-in-sprague-dawley-rats
#17
Subramani Parasuraman, Khor Ming Zhen, Urmila Banik, Parayil Varghese Christapher
OBJECTIVE: To evaluate the effect of curcumin on olanzapine-induced obesity in rats. MATERIALS AND METHODS: Sprague-Dawley (SD) rats were used for experiments. The animals were divided into six groups, namely, normal control, olanzapine control, betahistine (10 mg/kg), and curcumin 50, 100, and 200 mg/kg treated groups. Except the normal control group, all other animals were administered with olanzapine 4 mg/kg intraperitoneally to induce obesity. The drugs were administered once daily, per oral for 28 days...
July 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28827869/predictors-of-intention-to-quit-tobacco-among-construction-site-workers-in-delhi-india
#18
Mamta Parashar, Mitasha Singh, Rashmi Agarwalla, Meely Panda, Rambha Pathak
BACKGROUND: Information on predictors of quitting behavior among construction site tobacco users is scarce in India. Hence, this study was conducted to assess the intention of tobacco users toward quitting and its predictors with reference to sociodemographic profile. METHODOLOGY: A community-based, observational study was conducted on adult 172 construction site workers in a university campus of Delhi. Data were collected by an interview using the WHO-adopted, pretested, semi-structured questionnaire...
April 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28827849/oral-health-status-related-to-social-behaviors-among-6-11-year-old-schoolchildren-in-kosovo
#19
Lulëjeta Ferizi, Fatmir Dragidella, Gloria Staka, Venera Bimbashi, Shefqet Mrasori
AIM: The aim of the present study was to evaluate the current oral health status among schoolchildren in Kosovo aged 6-11 years. MATERIAL AND METHODS: A study included 5679 schoolchildren aged 6 -11 years, from different towns of Kosovo. Dental health status was evaluated using the World Health Organization (WHO) caries diagnostic criteria for decayed, missing and filled teeth (dmft/DMFT index), for deciduous and permanent dentition. The observed children have answered a number of questions about their oral hygiene, eating habits, and dental visits...
June 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28827830/treatment-effects-between-monotherapy-of-donepezil-versus-combination-with-memantine-for-alzheimer-disease-a-meta-analysis
#20
Ruey Chen, Pi-Tuan Chan, Hsin Chu, Yu-Cih Lin, Pi-Chen Chang, Chien-Yu Chen, Kuei-Ru Chou
BACKGROUND: This is the first meta-analysis to compare the treatment effects and safety of administering donepezil alone versus a combination of memantine and donepezil to treat patients with moderate to severe Alzheimer Disease, particularly regarding cognitive functions, behavioral and psychological symptoms in dementia (BPSD), and global functions. METHODS: PubMed, Medline, Embase, PsycINFO, and Cochrane databases were used to search for English and non-English articles for inclusion in the meta-analysis to evaluate the effect size and incidence of adverse drug reactions of different treatments...
2017: PloS One
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