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Epidural electrical stimulation

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https://www.readbyqxmd.com/read/28803750/motor-cortex-and-spinal-cord-neuromodulation-promote-corticospinal-tract-axonal-outgrowth-and-motor-recovery-after-cervical-contusion-spinal-cord-injury
#1
N Zareen, M Shinozaki, D Ryan, H Alexander, A Amer, D Truong, N Khadka, A Sarkar, S Naeem, M Bikson, J Martin
Cervical injuries are the most common form of SCI. In this study, we used a neuromodulatory approach to promote skilled movement recovery and repair of the corticospinal tract (CST) after a moderately severe C4 midline contusion in adult rats. We used bilateral epidural intermittent theta burst (iTBS) electrical stimulation of motor cortex to promote CST axonal sprouting and cathodal trans-spinal direct current stimulation (tsDCS) to enhance spinal cord activation to motor cortex stimulation after injury. We used Finite Element Method (FEM) modeling to direct tsDCS to the cervical enlargement...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28752624/paired-motor-cortex-and-cervical-epidural-electrical-stimulation-timed-to-converge-in-the-spinal-cord-promotes-lasting-increases-in-motor-responses
#2
Asht M Mishra, Ajay Pal, Disha Gupta, Jason B Carmel
Convergent activity in neural circuits can generate changes at their intersection. The rules of paired electrical stimulation are best understood for paradigms that stimulate input circuits and their targets. We took a different approach by targeting the interaction of descending motor pathways and large-diameter afferents in the spinal cord. We hypothesized that pairing stimulation of motor cortex and cervical spinal cord would strengthen motor responses through their convergence. We placed epidural electrodes over motor cortex and the dorsal cervical spinal cord in rats; motor evoked potentials (MEPs) were measured from biceps...
July 28, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28560030/thoracolumbar-epidural-anaesthesia-with-0-5-bupivacaine-with-or-without-methadone-in-goats
#3
Priscila Dos Santos Silva, Paulo Fantinato-Neto, André Nicolai Elias Silva, Eduardo Harry Birgel Junior, Adriano Bonfim Carregaro
BACKGROUND: Epidural anaesthesia is one of the most commonly used locoregional techniques in ruminants. The lumbosacral epidural technique is reasonably easy to perform and requires low volumes of local anaesthetic drug to allow procedures caudal to the umbilicus. However, surgical procedures in the flank of the animal would require an increased volume of drugs. The anaesthetized area provided by thoracic epidural technique is larger than the lumbosacral technique; however the former is rather challenging to perform...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28489550/a-fully-integrated-wireless-soc-for-motor-function-recovery-after-spinal-cord-injury
#4
Yi-Kai Lo, Yen-Cheng Kuan, Stanislav Culaclii, Brian Kim, Po-Min Wang, Chih-Wei Chang, Jonathan A Massachi, Minji Zhu, Kuanfu Chen, Parag Gad, V Reggie Edgerton, Wentai Liu
This paper presents a wirelessly powered, fully integrated system-on-a-chip (SoC) supporting 160-channel stimulation, 16-channel recording, and 48-channel bio-impedance characterization to enable partial motor function recovery through epidural spinal cord electrical stimulation. A wireless transceiver is designed to support quasi full-duplex data telemetry at a data rate of 2 Mb/s. Furthermore, a unique in situ bio-impedance characterization scheme based on time-domain analysis is implemented to derive the Randles cell electrode model of the electrode-electrolyte interface...
June 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28474539/induced-neural-activity-promotes-an-oligodendroglia-regenerative-response-in-the-injured-spinal-cord-and-improves-motor-function-after-spinal-cord-injury
#5
Qun Li, Thierry Houdayer, Su Liu, Visar Belegu
Myelination in central nervous system (CNS) is a dynamic process that includes birth of oligodendrocyte progenitor cells (OPCs), their differentiation into oligodendrocytes, and ensheathment of axons. Regulation of myelination by neuronal activity has emerged as a new mechanism of CNS plasticity. Indeed, activity-dependent myelination has been shown to regulate sensory, motor and cognitive functions. In this work, we aimed to employ this mechanism of CNS plasticity by utilizing induced neuronal activity to promote remyelination and functional recovery in a subchronic model of SCI...
May 5, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28400498/effect-of-thoracic-epidural-anesthesia-on-heart-rate-variability-in-a-porcine-model
#6
Arjun Mahajan, Tatsuo Takamiya, Peyman Benharash, Wei Zhou
Heart rate variability (HRV) is increasingly recognized as a means of evaluating autonomic tone. Thoracic epidural anesthesia (TEA) has been previously demonstrated to suppress the electrical storms in patients. However, the effect of TEA on HRV during sympathoexcitation remains unknown. In this study, we aimed to determine the effects of TEA on HRV response to left stellate ganglion stimulation (LSS) in a porcine model. In 12 anesthetized pigs after insertion of an epidural catheter to T1 level, a median sternotomy was performed to expose the heart and the left stellate ganglion...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28385196/enabling-task-specific-volitional-motor-functions-via-spinal-cord-neuromodulation-in-a-human-with-paraplegia
#7
Peter J Grahn, Igor A Lavrov, Dimitry G Sayenko, Meegan G Van Straaten, Megan L Gill, Jeffrey A Strommen, Jonathan S Calvert, Dina I Drubach, Lisa A Beck, Margaux B Linde, Andrew R Thoreson, Cesar Lopez, Aldo A Mendez, Parag N Gad, Yury P Gerasimenko, V Reggie Edgerton, Kristin D Zhao, Kendall H Lee
We report a case of chronic traumatic paraplegia in which epidural electrical stimulation (EES) of the lumbosacral spinal cord enabled (1) volitional control of task-specific muscle activity, (2) volitional control of rhythmic muscle activity to produce steplike movements while side-lying, (3) independent standing, and (4) while in a vertical position with body weight partially supported, voluntary control of steplike movements and rhythmic muscle activity. This is the first time that the application of EES enabled all of these tasks in the same patient within the first 2 weeks (8 stimulation sessions total) of EES therapy...
April 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28358748/effect-of-thoracic-epidural-anesthesia-on-ventricular-excitability-in-a-porcine-model
#8
Kimberly Howard-Quijano, Tatsuo Takamiya, Erica A Dale, Kentaro Yamakawa, Wei Zhou, Una Buckley, Aman Mahajan
BACKGROUND: Imbalances in the autonomic nervous system, namely, excessive sympathoexcitation, contribute to ventricular tachyarrhythmias. While thoracic epidural anesthesia clinically suppresses ventricular tachyarrhythmias, its effects on global and regional ventricular electrophysiology and electrical wave stability have not been fully characterized. The authors hypothesized that thoracic epidural anesthesia attenuates myocardial excitability and the proarrhythmic effects of sympathetic hyperactivity...
June 2017: Anesthesiology
https://www.readbyqxmd.com/read/28215814/what-is-the-evidence-the-issue-of-verifying-correct-needle-position-during-epidural-anaesthesia-in-dogs
#9
REVIEW
Chiara Adami, Karine Gendron
OBJECTIVES: To review the methods for verifying the needle position while performing epidural anaesthesia in dogs, and to discuss the advantages, disadvantages, usefulness and reliability of each technique in the experimental and clinical research setting. DATABASES USED: PubMed, Scopus, Google Scholar and the Basel University Library online catalogues; the latter, which was provided by the University of Berne, were used as databases. The results were filtered manually based on the titles and abstracts in order to narrow the field...
March 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28207450/response-to-response-patterns-to-the-electric-stimulation-of-epidural-catheters-in-pregnant-women-a-randomized-controlled-trial-of-uniport-versus-multiport-catheters
#10
Ellis Muggleton, Tuelin Muggleton
No abstract text is available yet for this article.
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28192079/electrical-neuromodulation-of-the-cervical-spinal-cord-facilitates-forelimb-skilled-function-recovery-in-spinal-cord-injured-rats
#11
Monzurul Alam, Guillermo Garcia-Alias, Benita Jin, Jonathan Keyes, Hui Zhong, Roland R Roy, Yury Gerasimenko, Daniel C Lu, V Reggie Edgerton
Enabling motor control by epidural electrical stimulation of the spinal cord is a promising therapeutic technique for the recovery of motor function after a spinal cord injury (SCI). Although epidural electrical stimulation has resulted in improvement in hindlimb motor function, it is unknown whether it has any therapeutic benefit for improving forelimb fine motor function after a cervical SCI. We tested whether trains of pulses delivered at spinal cord segments C6 and C8 would facilitate the recovery of forelimb fine motor control after a cervical SCI in rats...
May 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28165427/developing-and-evaluating-a-flexible-wireless-microcoil-array-based-integrated-interface-for-epidural-cortical-stimulation
#12
Xing Wang, Sharjeel A Chaudhry, Wensheng Hou, Xiaofeng Jia
Stroke leads to serious long-term disability. Electrical epidural cortical stimulation has made significant improvements in stroke rehabilitation therapy. We developed a preliminary wireless implantable passive interface, which consists of a stimulating surface electrode, receiving coil, and single flexible passive demodulated circuit printed by flexible printed circuit (FPC) technique and output pulse voltage stimulus by inductively coupling an external circuit. The wireless implantable board was implanted in cats' unilateral epidural space for electrical stimulation of the primary visual cortex (V1) while the evoked responses were recorded on the contralateral V1 using a needle electrode...
February 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28159637/transcranial-magnetic-stimulation-tms-responses-elicited-in-hindlimb-muscles-as-an-assessment-of-synaptic-plasticity-in-spino-muscular-circuitry-after-chronic-spinal-cord-injury
#13
Hayk A Petrosyan, Valentina Alessi, Sue A Sisto, Mark Kaufman, Victor L Arvanian
Electromagnetic stimulation applied at the cranial level, i.e. transcranial magnetic stimulation (TMS), is a technique for stimulation and neuromodulation used for diagnostic and therapeutic applications in clinical and research settings. Although recordings of TMS elicited motor-evoked potentials (MEP) are an essential diagnostic tool for spinal cord injured (SCI) patients, they are reliably recorded from arm, and not leg muscles. Mid-thoracic contusion is a common SCI that results in locomotor impairments predominantly in legs...
March 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/27955948/array-focal-cortical-stimulation-enhances-motor-function-recovery-and-brain-remodeling-in-a-rat-model-of-ischemia
#14
Jing Yang, Lu Liu, Tao Li, Chengyan Li
OBJECTIVE: Using a new microelectrode array implanted into the cranial window employing a new stimulation protocol, we investigated the effects of the implanted electrode arrays on both motor map plasticity and neural regeneration in a rodent model of stroke. MATERIALS AND METHODS: Rats were pretrained on single-pellet retrieval task, then received focal ischemic infarction and microelectrode arrays implantation. Rats in the cortical stimulation (CS) group received daily electrical stimulation (1 hour each day) for 14 days whereas animals in the no stimulation (NS) group did not receive electrical stimulation and only underwent motor mapping...
March 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27881958/motor-cortex-neurostimulation-technologies-for-chronic-post-stroke-pain-implications-of-tissue-damage-on-stimulation-currents
#15
Anthony T O'Brien, Rivadavio Amorim, R Jarrett Rushmore, Uri Eden, Linda Afifi, Laura Dipietro, Timothy Wagner, Antoni Valero-Cabré
Background: Central post stroke pain (CPSP) is a highly refractory syndrome that can occur after stroke. Primary motor cortex (M1) brain stimulation using epidural brain stimulation (EBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS) have been explored as potential therapies for CPSP. These techniques have demonstrated variable clinical efficacy. It is hypothesized that changes in the stimulating currents that are caused by stroke-induced changes in brain tissue conductivity limit the efficacy of these techniques...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27830790/a-brain-spine-interface-alleviating-gait-deficits-after-spinal-cord-injury-in-primates
#16
Marco Capogrosso, Tomislav Milekovic, David Borton, Fabien Wagner, Eduardo Martin Moraud, Jean-Baptiste Mignardot, Nicolas Buse, Jerome Gandar, Quentin Barraud, David Xing, Elodie Rey, Simone Duis, Yang Jianzhong, Wai Kin D Ko, Qin Li, Peter Detemple, Tim Denison, Silvestro Micera, Erwan Bezard, Jocelyne Bloch, Grégoire Courtine
Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces have directly linked cortical activity to electrical stimulation of muscles, and have thus restored grasping abilities after hand paralysis. Theoretically, this strategy could also restore control over leg muscle activity for walking. However, replicating the complex sequence of individual muscle activation patterns underlying natural and adaptive locomotor movements poses formidable conceptual and technological challenges...
November 10, 2016: Nature
https://www.readbyqxmd.com/read/27798422/epidural-and-transcutaneous-spinal-electrical-stimulation-for-restoration-of-movement-after-incomplete-and-complete-spinal-cord-injury
#17
Winfried Mayr, Matthias Krenn, Milan R Dimitrijevic
PURPOSE OF REVIEW: The Purpose of this review is to outline and explain the therapeutic use of electrical spinal cord stimulation (SCS) for modification of spinal motor output. Central functional stimulation provides afferent input to posterior root neurons and is applied to improve volitional movements, posture and their endurance, control spasticity, and improve bladder function or perfusion in the lower limbs. Clinical accomplishments strongly depend on each individual's physiological state and specific methodical adaptation to that physiological state...
December 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27763875/modulation-of-respiratory-output-by-cervical-epidural-stimulation-in-the-anesthetized-mouse
#18
Ruyi Huang, Serapio M Baca, Jason W Worrell, Xingquan Liu, Yeji Seo, James C Leiter, Daniel C Lu
Respiration is produced and controlled by well-characterized brain stem nuclei, but the contributions of spinal circuits to respiratory control and modulation remain under investigation. Many respiratory studies are conducted in in vitro preparations (e.g., brain stem slice) obtained from neonatal rodents. While informative, these studies do not fully recapitulate the complex afferent and efferent neural circuits that are likely to be involved in eupnea (i.e., quiet breathing). To begin to investigate spinal contributions to respiration, we electrically stimulated the cervical spinal cord during unassisted respiration in anesthetized, intact mice...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27701161/bioelectric-medicine-and-devices-for-the-treatment-of-spinal-cord-injury
#19
REVIEW
Tess Torregrosa, Ryan A Koppes
Recovery of motor control is paramount for patients living with paralysis following spinal cord injury (SCI). While a cure or regenerative intervention remains on the horizon for the treatment of SCI, a number of neuroprosthetic devices have been employed to treat and mitigate the symptoms of paralysis associated with injuries to the spinal column and associated comorbidities. The recent success of epidural stimulation to restore voluntary motor function in the lower limbs of a small cohort of patients has breathed new life into the promise of electric-based medicine...
2016: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/27658771/current-experience-of-spinal-neuromodulation-in-chronic-pain-is-there-a-role-in-children-and-young-people
#20
REVIEW
David Pang
INTRODUCTION: Chronic pain in children has been an under-recognized problem compared to adult pain. The aim of management is to help children and their families cope with the symptoms rather than a cure. Current medical treatments to reduce pain intensity are often short lived, poorly tolerated or ineffective. RESULTS: The use of electrical stimulation to treat pain is the current basis of modern Neuromodulation at the spinal cord and has been well established as spinal cord stimulation in adult practice...
January 2017: European Journal of Paediatric Neurology: EJPN
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