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inflammatory bowel disease dog

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https://www.readbyqxmd.com/read/28089357/localization-of-toll-like-receptor-tlr-2-and-tlr4-mrna-in-the-colorectal-mucosa-of-miniature-dachshunds-with-inflammatory-colorectal-polyps
#1
N Yokoyama, H Ohta, J Yamazaki, Y Kagawa, O Ichii, N Khoirun, T Morita, T Osuga, S Y Lim, N Sasaki, K Morishita, K Nakamura, M Takiguchi
Inflammatory colorectal polyps (ICRPs) are characterized by the formation of multiple or solitary polyps with marked neutrophil infiltration in the colorectal area, and are speculated to be a novel form of breed-specific canine idiopathic inflammatory bowel disease (IBD). In human IBD, toll-like receptor (TLR) 2 and TLR4 have been reported to be involved in the pathogenesis of the disease. The aim of this study was to evaluate the expression of TLR2 and TLR4 mRNA in the colorectal mucosa of dogs with ICRPs by in-situ hybridization using an RNAscope assay...
January 12, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28049868/expression-of-epithelial-cell-derived-cytokine-genes-in-the-duodenal-and-colonic-mucosae-of-dogs-with-chronic-enteropathy
#2
Hironari Osada, Misato Ogawa, Ayana Hasegawa, Makoto Nagai, Junsuke Shirai, Kazuaki Sasaki, Minoru Shimoda, Hiroshi Itoh, Hirotaka Kondo, Keitaro Ohmori
It remains unclear whether epithelial cell-derived cytokines, including interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), contribute to development of canine chronic enteropathy (CE), which includes antibiotic-responsive enteropathy (ARE), food-responsive enteropathy (FRE) and inflammatory bowel disease (IBD). In the present study, we examined mRNA expression of il-25, il-33 and tslp in the duodenal and colonic mucosae of dogs with ARE, FRE and IBD. Real-time PCR analysis revealed that mRNA expression of il-33 was significantly lower in the duodenum in dogs with FRE than in healthy dogs...
December 29, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28029282/assessment-of-eosinophil-peroxidase-as-a-potential-diagnostic-and-prognostic-marker-in-dogs-with-inflammatory-bowel-disease
#3
Idil Bastan, Nicholas A Robinson, Xiao Na Ge, Aaron K Rendahl, Savita P Rao, Robert J Washabau, P Sriramarao
OBJECTIVE To evaluate a method for identifying intact and degranulated eosinophils in the small intestine of dogs with inflammatory bowel disease (IBD) by use of a monoclonal antibody (mAb) against eosinophil peroxidase (EPX). ANIMALS 11 untreated dogs with IBD, 5 dogs with IBD treated with prednisolone, and 8 control dogs with no clinical evidence of gastrointestinal tract disease and no immunosuppressive treatment. PROCEDURES 4-μm-thick sections of paraffin-embedded tissues from necropsy specimens were immunostained with EPX mAb...
January 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27941060/effects-of-a-structured-exercise-programme-in-sedentary-dogs-with-chronic-diarrhoea
#4
H-P Huang, Y-H Lien
The aim of this investigation was to evaluate the effects of a structured exercise programme in sedentary dogs with chronic diarrhoea. Twenty-two dogs were enrolled in the study. All dogs received oral prednisolone (1 mg/kg/day for 14 days, followed by a tapering dosage) for 10 weeks. After four weeks of prednisolone treatment, dogs were assigned to either the exercise or control group (n=11 each). Owners of dogs in the exercise group were instructed to guide their dogs in structured exercise training (low-intensity to moderate-intensity aerobic and resistance exercise three to five days per week)...
December 9, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27931211/gonadectomy-effects-on-the-risk-of-immune-disorders-in-the-dog-a-retrospective-study
#5
Crystal R Sundburg, Janelle M Belanger, Danika L Bannasch, Thomas R Famula, Anita M Oberbauer
BACKGROUND: Gonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. This study evaluated the prevalence and risk of atopic dermatitis (ATOP), autoimmune hemolytic anemia (AIHA), canine myasthenia gravis (CMG), colitis (COL), hypoadrenocorticism (ADD), hypothyroidism (HYPO), immune-mediated polyarthritis (IMPA), immune-mediated thrombocytopenia (ITP), inflammatory bowel disease (IBD), lupus erythematosus (LUP), and pemphigus complex (PEMC), for intact females, intact males, neutered females, and neutered males...
December 8, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27863539/single-nucleotide-polymorphisms-in-major-histocompatibility-class-ii-haplotypes-are-associated-with-potential-resistance-to-inflammatory-bowel-disease-in-german-shepherd-dogs
#6
Atiyeh Peiravan, Karin Allenspach, Alisdair M Boag, Francesca Soutter, Angela Holder, Brian Catchpole, Lorna J Kennedy, Dirk Werling, Fabio Procoli
German shepherd dogs (GSD) in the UK are at increased risk of developing the Inflammatory Bowel Disaese (IBD). IBD is believed to be a multifactorial immune mediated disease affecting genetically predisposed dogs. The aim of the current study was to investigate whether susceptibility to IBD in GSD is associated with the major histocompatibility complex (MHC) class II locus (Dog Leukocyte Antigen, DLA). Sequence-based genotyping of the three polymorphic DLA genes DLA-DRB1, -DQA1 and -DQB1 was performed in 56 GSDs affected by IBD and in 50 breed-matched controls without any history of gastrointestinal signs...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27747868/inflammatory-bowel-disease-versus-chronic-enteropathy-in-dogs-are-they-one-and-the-same
#7
J R S Dandrieux
The aim of this review is to discuss why "chronic enteropathy" might be a better term than "inflammatory bowel disease" in dogs, because the treatment and outcome of the disease is very different from that of inflammatory bowel disease in humans. The effect of food, antibiotics and immunosuppressant drugs on chronic enteropathy will be reviewed. New treatments under investigation will also be introduced. Although there are several studies evaluating treatment of chronic enteropathy in dogs, the quality and quantity of evidence supporting individual therapies remains scarce and more work is needed to improve management of this disease...
October 16, 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27698166/validation-of-three-automated-assays-for-total-antioxidant-capacity-determination-in-canine-serum-samples
#8
Camila Peres Rubio, Josefa Hernández-Ruiz, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Marino Bañón Arnao, José Joaquín Ceron
We performed analytical validation of 3 automated assays of the total antioxidant capacity (TAC) in canine serum and evaluated their use in dogs with inflammatory bowel disease. The assays were based on the generation of a 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical cation (ABTS•(+)) in aqueous media, which produces a blue-green color. The antioxidants present in the sample remove the chromogen in proportion to their concentrations. The assays differed mainly in the way in which this radical was produced...
November 2016: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/27694806/dog-and-human-inflammatory-bowel-disease-rely-on-overlapping-yet-distinct-dysbiosis-networks
#9
Yoshiki Vázquez-Baeza, Embriette R Hyde, Jan S Suchodolski, Rob Knight
Inflammatory bowel disease (IBD) is an autoimmune condition that is difficult to diagnose, and animal models of this disease have questionable human relevance(1). Here, we show that the dysbiosis network underlying IBD in dogs differs from that in humans, with some bacteria such as Fusobacterium switching roles between the two species (as Bacteroides fragilis switches roles between humans and mice)(2). For example, a dysbiosis index trained on humans fails when applied to dogs, but a dog-specific dysbiosis index achieves high correlations with the overall dog microbial community diversity patterns...
October 3, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27538863/serum-cobalamin-vitamin-b12-concentrations-in-rhesus-macaques-macaca-mulatta-and-pigtailed-macaques-macaca-nemestrina-with-chronic-idiopathic-diarrhea
#10
Jessica M Izzi, Sarah E Beck, Robert J Adams, Kelly A Metcalf Pate, Eric K Hutchinson
Chronic diarrhea poses a significant threat to the health of NHP research colonies, and its primary etiology remains unclear. In macaques, the clinical presentation of intractable diarrhea and weight loss that are accompanied by inflammatory infiltrates within the gastrointestinal tract closely resembles inflammatory bowel disease of humans, dogs, and cats, in which low serum and tissue cobalamin (vitamin B12) levels are due to intestinal malabsorption. We therefore hypothesized that macaques with chronic idiopathic diarrhea (CID) have lower serum cobalamin concentrations than do healthy macaques...
2016: Comparative Medicine
https://www.readbyqxmd.com/read/27408833/an-lc-ms-ms-method-for-the-determination-of-budesonide-and-16%C3%AE-hydroxyprednisolone-in-dog-plasma
#11
Teresa Gazzotti, Andrea Barbarossa, Elisa Zironi, Paola Roncada, Marco Pietra, Giampiero Pagliuca
Although budesonide is frequently used in veterinary medicine for the treatment of canine respiratory and bowel inflammatory diseases, knowledge is lacking regarding its kinetics in this species. We developed and validated a liquid chromatography-tandem mass spectrometry method for the determination of budesonide and its metabolite 16α-hydroxyprednisolone in dog plasma. The analytes were extracted by solid phase extraction and analysis was performed by high performance liquid chromatography-tandem mass spectrometry, with positive electrospray ionization...
2016: MethodsX
https://www.readbyqxmd.com/read/27370026/validation-of-an-automated-assay-for-the-measurement-of-cupric-reducing-antioxidant-capacity-in-serum-of-dogs
#12
Camila Peres Rubio, Asta Tvarijonaviciute, Silvia Martinez-Subiela, Josefa Hernández-Ruiz, José Joaquin Cerón
BACKGROUND: The objective of the present study was to optimize and validate an automated method to assess the total antioxidant capacity (TAC) in serum of dogs using the cupric reducing antioxidant capacity (CUPRAC) methodology (TACc) with bathocuproinedisulfonic acid disodium salt as chelating agent, evaluating also possible variations due to the use of two different automated analyzers. The method is based on the reduction of Cu(2+) into Cu(1+) by the action of the non-enzymatic antioxidants that are present in the sample...
July 2, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27359251/focal-intestinal-lipogranulomatous-lymphangitis-in-10-dogs
#13
A Lecoindre, P Lecoindre, J L Cadoré, M Chevallier, S Guerret, G Derré, S P Mcdonough, K W Simpson
OBJECTIVES: To describe the clinical and pathological features of canine focal lipogranulomatous lymphangitis, to evaluate its underlying infectious cause and to compare it with human Crohn's disease. METHODS: Retrospective review of case records with a histopathological diagnosis of focal lipogranulomatous lymphangitis. Bacterial and fungal colonisation was evaluated using fluorescence in situ hybridisation and histochemical staining, respectively. A comparison with Crohn's disease was performed by a human pathologist...
September 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27306031/does-canine-inflammatory-bowel-disease-influence-gut-microbial-profile-and-host-metabolism
#14
Jia Xu, Adronie Verbrugghe, Marta Lourenço, Geert P J Janssens, Daisy J X Liu, Tom Van de Wiele, Venessa Eeckhaut, Filip Van Immerseel, Isabel Van de Maele, Yufeng Niu, Guido Bosch, Greet Junius, Brigitte Wuyts, Myriam Hesta
BACKGROUND: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis. Several studies have investigated the gut microbial ecology of dogs with IBD but it is yet unclear if this microbial profile can alter the nutrient metabolism of the host. The aim of the present study was to characterize the faecal bacterial profile and functionality as well as to determine host metabolic changes in IBD dogs...
June 16, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27285902/horse-species-symposium-canine-intestinal-microbiology-and-metagenomics-from-phylogeny-to-function
#15
B C Guard, J S Suchodolski
Recent molecular studies have revealed a complex microbiota in the dog intestine. Convincing evidence has been reported linking changes in microbial communities to acute and chronic gastrointestinal inflammation, especially in canine inflammatory bowel disease (IBD). The most common microbial changes observed in intestinal inflammation are decreases in the bacterial phyla Firmicutes (i.e., Lachnospiraceae, Ruminococcaceae, and ) and Bacteroidetes, with concurrent increases in Proteobacteria (i.e., ). Due to the important role of microbial-derived metabolites for host health, it is important to elucidate the metabolic consequences of gastrointestinal dysbiosis and physiological pathways implicated in specific disease phenotypes...
June 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27159733/retrospective-evaluation-of-the-administration-of-25-human-albumin-to-dogs-with-protein-losing-enteropathy-21-cases-2003-2013
#16
Kimberly A Loyd, Christine G Cocayne, Julie M Cridland, Wayne R Hause
OBJECTIVE: To describe the administration of 25% human serum albumin (HSA) to dogs diagnosed with idiopathic inflammatory bowel disease (IBD) and protein-losing enteropathy (PLE). The secondary objectives were to report any acute and delayed adverse events and the effect of corticosteroids on the development of these reactions. DESIGN: Retrospective study (2003-2013). SETTING: Private referral hospital. ANIMALS: Twenty-one client owned dogs diagnosed with PLE and idiopathic IBD that received ≥ 1 transfusion of 25% HSA...
July 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27096800/clinical-endoscopic-and-histopathological-evaluation-of-the-efficacy-of-budesonide-in-the-treatment-of-inflammatory-bowel-disease-in-dogs
#17
A Rychlik, A Kołodziejska-Sawerska, M Nowicki, M Szweda
This study evaluates the efficacy of budesonide in the treatment of inflammatory bowel disease (IBD) in dogs based on the results of clinical, endoscopic and histopathological examinations. The severity of clinical symptoms was assessed based on CIBDAI scores, and macroscopic and histopathological changes were described in accordance with the recommendations of the WSAVA Gastrointestinal Standardization Group for 2008. The results of the experiment revealed that budesonide does not offer effective treatment for canine IBD...
2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/27066769/concise-review-stem-cell-trials-using-companion-animal-disease-models
#18
Andrew M Hoffman, Steven W Dow
Studies to evaluate the therapeutic potential of stem cells in humans would benefit from more realistic animal models. In veterinary medicine, companion animals naturally develop many diseases that resemble human conditions, therefore, representing a novel source of preclinical models. To understand how companion animal disease models are being studied for this purpose, we reviewed the literature between 2008 and 2015 for reports on stem cell therapies in dogs and cats, excluding laboratory animals, induced disease models, cancer, and case reports...
July 2016: Stem Cells
https://www.readbyqxmd.com/read/27017054/fecal-s100a12-concentration-predicts-a-lack-of-response-to-treatment-in-dogs-affected-with-chronic-enteropathy
#19
Romy M Heilmann, Maria Volkmann, Cristiane C Otoni, Niels Grützner, Barbara Kohn, Albert E Jergens, Jörg M Steiner
S100A12 is a potential biomarker of gastrointestinal inflammation in dogs and fecal S100A12 concentrations are correlated with disease severity and outcome. The aim of the present study was to investigate whether there was any association between pre-treatment fecal S100A12 concentrations in dogs affected with chronic enteropathy (CE) and the response to treatment. Dogs affected with CE were recruited into the study and were classified as antibiotic-responsive diarrhea (ARD; n = 9), food-responsive diarrhea (FRD; n = 30) or idiopathic inflammatory bowel disease (IBD; n = 25)...
September 2016: Veterinary Journal
https://www.readbyqxmd.com/read/26986208/is-serum-total-ldh-evaluation-able-to-differentiate-between-alimentary-lymphoma-and-inflammatory-bowel-disease-in-a-real-world-clinical-setting
#20
Rossella Terragni, Antonio M Morselli-Labate, Massimo Vignoli, Enrico Bottero, Barbara Brunetti, Jimmy H Saunders
CONTEXT: An increase in enzyme lactate dehydrogenase (LDH) in serum is a negative prognostic factor for survival in cats affected by lymphoma. Measuring LDH at the time of diagnosis has been studied for differentiating neoplastic disease from non-neoplastic disease in dogs. Inflammatory bowel disease (IBD) and alimentary lymphoma are common diseases in cats. OBJECTIVE: The aim of this study was to determine whether elevation of total LDH occurred in cats with alimentary lymphoma and non-neoplastic gastrointestinal disease, such as IBD, and to evaluate whether this enzyme is useful in supporting the differential diagnosis of these specific diseases...
2016: PloS One
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