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inflammatory bowel disease dog

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https://www.readbyqxmd.com/read/29743297/interleukin-1%C3%AE-expression-is-increased-in-the-duodenum-of-dogs-with-idiopathic-inflammatory-bowel-disease
#1
Martin Hawes, Anna Riddle, Joseph Kirk, Albert Jergens, Karin Allenspach
No abstract text is available yet for this article.
May 9, 2018: Veterinary Record
https://www.readbyqxmd.com/read/29667183/effect-of-enterococcus-faecium-sf68-on-serum-cobalamin-and-folate-concentrations-in-healthy-dogs
#2
R Lucena, A B Olmedilla, B Blanco, M Novales, P J Ginel
OBJECTIVE: To study the effect of a 14-day administration of the probiotic Enterococcus faecium SF68 on serum concentrations of cobalamin and folate in healthy dogs. MATERIALS AND METHODS: Thirty-six healthy dogs were randomly allocated between probiotic and control groups. Enterococcus faecium SF68 was administered to the probiotic group for 14 days whereas the control group did not receive any product. A blood sample was taken from all dogs when starting the administration (day 1), when the administration ended (day 14) and 14 days later (day 28)...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29665827/effect-of-selected-gastrointestinal-parasites-and-viral-agents-on-fecal-s100a12-concentrations-in-puppies-as-a-potential-comparative-model
#3
Romy M Heilmann, Aurélien Grellet, Niels Grützner, Shannon M Cranford, Jan S Suchodolski, Sylvie Chastant-Maillard, Jörg M Steiner
BACKGROUND: Previous data suggest that fecal S100A12 has clinical utility as a biomarker of chronic gastrointestinal inflammation (idiopathic inflammatory bowel disease) in both people and dogs, but the effect of gastrointestinal pathogens on fecal S100A12 concentrations is largely unknown. The role of S100A12 in parasite and viral infections is also difficult to study in traditional animal models due to the lack of S100A12 expression in rodents. Thus, the aim of this study was to evaluate fecal S100A12 concentrations in a cohort of puppies with intestinal parasites (Cystoisospora spp...
April 17, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29663515/determining-optimal-therapy-of-dogs-with-chronic-enteropathy-by-measurement-of-serum-citrulline
#4
Magda Gerou-Ferriani, Rhiannon Allen, Peter-John M Noble, Alexander J German, Marco Caldin, Daniel J Batchelor
BACKGROUND: Serum concentration of citrulline is a useful biomarker in human intestinal disease and indicates globally reduced enterocyte mass and absorptive function in various disease states. OBJECTIVES: To determine whether serum citrulline concentration is a biomarker in chronic enteropathy (CE) in dogs, to provide useful information regarding optimal treatment or to predict outcome. ANIMALS: Seventy-four dogs with CE and 83 breed- and age-matched hospital controls with no clinical signs of intestinal disease...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29624721/serologic-and-fecal-markers-to-predict-response-to-induction-therapy-in-dogs-with-idiopathic-inflammatory-bowel-disease
#5
Cristiane C Otoni, Romy M Heilmann, Mercedes García-Sancho, Angel Sainz, Mark R Ackermann, Jan S Suchodolski, Jörg M Steiner, Albert E Jergens
BACKGROUND: Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD). OBJECTIVES: Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment. ANIMALS: Sixteen dogs with idioptahic IBD and 13 healthy dogs. METHODS: Prospective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment...
April 6, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29618371/s100a12-concentrations-and-myeloperoxidase-activities-are-increased-in-the-intestinal-mucosa-of-dogs-with-chronic-enteropathies
#6
Mohsen Hanifeh, Satu Sankari, Minna M Rajamäki, Pernilla Syrjä, Susanne Kilpinen, Jan S Suchodolski, Romy M Heilmann, Phillip Guadiano, Jonathan Lidbury, Jörg M Steiner, Thomas Spillmann
BACKGROUND: Intestinal mucosal S100A12 and myeloperoxidase (MPO) are inflammatory biomarkers in humans with inflammatory bowel disease (IBD). However, these biomarkers have not been studied in the intestinal mucosa of dogs with chronic enteropathies (CE), even though dogs with CE have increased S100A12 concentrations in feces and serum. This study investigated mucosal S100A12 concentrations and MPO activities in both dogs with CE and healthy Beagles. ELISA (S100A12 concentrations) and spectrophotometric methods (MPO activity) were used...
April 4, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29611642/the-effect-of-budesonide-on-the-expression-of-ki-67-and-pcna-and-the-apoptotic-index-in-dogs-with-inflammatory-bowel-disease
#7
M Szweda, A Rychlik, M Nowicki, E Kaczmar
The aim of this study was to determine the effect of budesonide on the expression of Ki-67 and PCNA proliferative antigens and the apoptotic index in the course of inflammatory bowel disease (IBD) and to evaluate the applicability of these markers in monitoring IBD treatment in dogs. The experiment was performed on 28 dogs of different breeds and both sexes, with body weight of 6 to 20 kg, aged 6 to 10 years. The animals diagnosed with IBD were divided into four groups of 7 dogs each, including three experimental groups characterized by various severity of IBD and a control group...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29604114/alterations-in-serum-amino-acid-concentrations-in-dogs-with-protein-losing-enteropathy
#8
Aarti Kathrani, Karin Allenspach, Andrea J Fascetti, Jennifer A Larsen, Edward J Hall
BACKGROUND: Certain amino acids are decreased in humans with inflammatory bowel disease (IBD) and supplementation with the same amino acids has shown beneficial effects in animal models of IBD. Currently, the amino acid status of dogs with protein-losing enteropathy (PLE) is unknown. HYPOTHESIS/OBJECTIVE: To determine if serum amino acid concentrations are abnormal in dogs with PLE and correlated with clinical and laboratory variables and outcome. ANIMALS: Thirty client-owned dogs diagnosed with PLE and 12 apparently healthy dogs seen at Bristol Veterinary School...
March 31, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29572935/effect-of-interleukin-1%C3%AE-on-occludin-mrna-expression-in-the-duodenal-and-colonic-mucosa-of-dogs-with-inflammatory-bowel-disease
#9
Misato Ogawa, Hironari Osada, Ayana Hasegawa, Hikaru Ohno, Nanako Yanuma, Kazuaki Sasaki, Minoru Shimoda, Junsuke Shirai, Hirotaka Kondo, Keitaro Ohmori
BACKGROUND: Mucosal imbalance of interleukin (IL)-1β and IL-1 receptor antagonist (Ra) has been reported in the duodenal mucosa of dogs with inflammatory bowel disease (IBD). However, the imbalance in the colonic mucosa and its role in duodenitis and colitis in IBD of dogs remain unclear. OBJECTIVES: To measure the expression of IL-1β and IL-1Ra proteins in the colonic mucosa of dogs with IBD, and to determine the effect of IL-1β on expression of occludin (ocln) mRNA, a tight junction component, in the duodenal and colonic mucosa of dogs with IBD...
March 23, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29530095/identification-of-matrix-metalloproteinase-2-and-9-activities-within-the-intestinal-mucosa-of-dogs-with-chronic-enteropathies
#10
Mohsen Hanifeh, Minna Marjaana Rajamäki, Pernilla Syrjä, Laura Mäkitalo, Susanne Kilpinen, Thomas Spillmann
BACKGROUND: Matrix metalloproteinases (MMPs) 2 and 9 are zinc- and calcium-dependent endopeptidases involved in the breakdown and reconstitution of extracellular matrix under both physiological and pathological conditions. Mucosal MMP-2 and -9 activities have been reported to be upregulated in the intestine of humans with inflammatory bowel disease (IBD), and in animal models of IBD. However, their involvement in the pathogenesis of canine chronic enteropathies (CE) is unknown. This study investigated mucosal pro- and active MMP-2 and -9 activities in dogs with CE and healthy dogs using gelatin zymography, and also to determine the association of their activities in dogs with CE with the canine IBD activity index (CIBDAI), histopathologic findings, the clinical outcome, and hypoalbuminemia...
March 12, 2018: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29475506/immunohistochemical-characterization-of-gastrointestinal-macrophages-phagocytes-in-dogs-with-inflammatory-bowel-disease-ibd-and-non-ibd-dogs
#11
Anna Wagner, Johannes Junginger, Frederik Lemensieck, Marion Hewicker-Trautwein
Intestinal Mϕ play a pivotal role in the maintenance of gut homeostasis, but can also contribute to inflammation such as inflammatory bowel disease (IBD). In contrast to human tissues, little is known about phenotypes of Mϕ in the canine gastrointestinal tract. Therefore, an immunohistochemical study was performed using Abs against Mϕ-associated molecules (Cluster of differentiation (CD)64, CD163, CD204, ionized calcium-binding adaptor molecule 1, L1 Ag, and MHC II) on stomach, duodenum, jejunum, ileum and colon from non-IBD dogs...
March 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29234895/intestinal-stem-cells-to-advance-drug-development-precision-and-regenerative-medicine-a-paradigm-shift-in-translational-research
#12
Jonathan P Mochel, Albert E Jergens, Dawn Kingsbury, Hyun Jung Kim, Martín G Martín, Karin Allenspach
Recent advances in our understanding of the intestinal stem cell niche and the role of key signaling pathways on cell growth and maintenance have allowed the development of fully differentiated epithelial cells in 3D organoids. Stem cell-derived organoids carry significant levels of proteins that are natively expressed in the gut and have important roles in drug transport and metabolism. They are, therefore, particularly relevant to study the gastrointestinal (GI) absorption of oral medications. In addition, organoids have the potential to serve as a robust preclinical model for demonstrating the effectiveness of new drugs more rapidly, with more certainty, and at lower costs compared with live animal studies...
December 12, 2017: AAPS Journal
https://www.readbyqxmd.com/read/29228248/comparison-of-the-intestinal-mucosal-microbiota-in-dogs-diagnosed-with-idiopathic-inflammatory-bowel-disease-and-dogs-with-food-responsive-diarrhea-before-and-after-treatment
#13
Katja Kalenyak, Anitha Isaiah, Romy M Heilmann, Jan S Suchodolski, Iwan A Burgener
We report the first study to evaluate the intestinal mucosal microbiota of dogs with inflammatory bowel disease (IBD) and dogs with food-responsive diarrhea (FRD) before and after treatment. It was hypothesized that differences in the microbial composition exist between both disease groups and within groups pre- vs. post-treatment. Duodenal and colonic biopsies were obtained endoscopically from 24 dogs (15 FRD, 9 IBD) before and after treatment. The intestinal microbiota was evaluated by Illumina sequencing of the bacterial 16S rRNA gene...
February 1, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29190196/clinical-and-histologic-features-of-acute-onset-erythroderma-in-dogs-with-gastrointestinal-disease-18-cases-2005-2015
#14
Christine L Cain, Charles W Bradley, Elizabeth A Mauldin
OBJECTIVE To describe the clinical and histologic features of acute erythroderma in dogs with gastrointestinal disease. DESIGN Retrospective case series. ANIMALS 18 dogs with erythroderma and gastrointestinal disease. PROCEDURES Medical records and biopsy specimens were reviewed. Information collected from medical records included signalment, clinical signs, physical examination and diagnostic test results, treatment, and outcome. The Naranjo algorithm was used to estimate the probability of an adverse drug reaction for each dog...
December 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29022381/effects-of-probiotic-bacteria-on-mucosal-polyamines-levels-in-dogs-with-ibd-and-colonic-polyps-a-preliminary-study
#15
G Rossi, M Cerquetella, S Scarpona, G Pengo, K Fettucciari, G Bassotti, A E Jergens, J S Suchodolski
Spermine (SPM) and its precursor putrescine (PUT), regulated by ornithine decarboxylase (ODC) and diamino-oxidase (DAO), are polyamines required for cell growth and proliferation. Only a few studies have investigated the anti-inflammatory and tumour inhibitory properties of probiotics on mucosal polyamine levels. We investigated the effects of a high concentration multistrain probiotic for human use on colonic polyamine biosynthesis in dogs. Histological sections (inflammatory bowel disease, n=10; polyposis, n=5) were assessed after receiving 112 to 225×109 lyophilised bacteria daily for 60 days at baseline (T0) and 30 days after treatment end (T90)...
February 27, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/28993566/fecal-microbiome-in-dogs-with-inflammatory-bowel-disease-and-intestinal-lymphoma
#16
Marie Omori, Shingo Maeda, Hirotaka Igarashi, Koichi Ohno, Kosei Sakai, Tomohiro Yonezawa, Ayako Horigome, Toshitaka Odamaki, Naoaki Matsuki
Although alteration of commensal microbiota is associated with chronic gastrointestinal (GI) diseases such as inflammatory bowel disease (IBD) in dogs, the microbiota composition in intestinal lymphoma, an important differential diagnosis of canine IBD, has not been investigated. The objective of this study was to compare the fecal microbiota in dogs with IBD, dogs with intestinal lymphoma, and healthy dogs. Eight dogs with IBD, eight dogs with intestinal lymphoma, and fifteen healthy dogs were included in the study...
November 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28905976/cutaneous-alternariosis-in-an-immunocompromised-dog-successfully-treated-with-cold-plasma-and-cessation-of-immunosuppressive-medication
#17
Janine Classen, Berrett Dengler, Christoph J Klinger, Sonya V Bettenay, Volker Rickerts, Ralf S Mueller
A cutaneous infection with Alternaria spp. was diagnosed in a 2-year-old male intact Irish setter dog, presenting with multifocal papules, plaques and ulcerations involving all four distal limbs, shoulder blades, scrotum, pinnae and nasal mucous membranes. The dog had been treated for inflammatory bowel disease and lymphangiectasia with immunosuppressive doses of cyclosporine and prednisolone for approximately 3 months. The diagnosis was based on clinical signs, the demonstration of fungal elements within skin biopsies, deep fungal culture and fungal PCR from a formalin-fixed tissue specimen...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28900347/-campylobacter-from-microbiology-to-prevention
#18
REVIEW
A Facciolà, R Riso, E Avventuroso, G Visalli, S A Delia, P Laganà
In last years, Campylobacter spp has become one of the most important foodborne pathogens even in high-income countries. Particularly, in Europe, Campylobacteriosis is, since 2005, the foodborne disease most frequently notified and the second in USA, preceded by the infection due to Salmonella spp. Campylobacter spp is a commensal microorganism of the gastrointestinal tract of many wild animals (birds such as ducks and gulls), farm animals (cattle and pigs) and companion animals (such as dogs and cats) and it is responsible for zoonoses...
June 2017: Journal of Preventive Medicine and Hygiene
https://www.readbyqxmd.com/read/28862348/immunophenotype-of-peripheral-blood-lymphocytes-in-dogs-with-inflammatory-bowel-disease
#19
A Galler, B C Rütgen, E Haas, A Saalmüller, R A Hirt, W Gerner, I Schwendenwein, B Richter, J G Thalhammer, N Luckschander-Zeller
BACKGROUND: Inflammatory bowel disease (IBD) is common in dogs. Despite the known importance of intestinal lymphocytes in its pathogenesis, little is known about the role of peripheral blood lymphocytes (PBLs) in IBD. OBJECTIVES: The aims of this study were (1) comparison of PBLs analyzed by flow cytometry (FCM) in IBD dogs and healthy controls and (2) comparison of PBLs in IBD dogs at the time of diagnosis and in dogs in clinical remission. ANIMALS: Whole blood samples of 19 IBD dogs at the time of diagnosis and blood samples of 6 dogs in clinical remission were collected...
November 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28738011/associations-between-gastric-dilatation-volvulus-in-great-danes-and-specific-alleles-of-the-canine-immune-system-genes-dla88-drb1-and-tlr5
#20
Michael A Harkey, Alexandra M Villagran, Gopalakrishnan M Venkataraman, Wendy M Leisenring, Meredith A J Hullar, Beverly J Torok-Storb
OBJECTIVE To determine whether specific alleles of candidate genes of the major histocompatibility complex (MHC) and innate immune system were associated with gastric dilatation-volvulus (GDV) in Great Danes. ANIMALS 42 healthy Great Danes (control group) and 39 Great Danes with ≥ 1 GDV episode. PROCEDURES Variable regions of the 2 most polymorphic MHC genes (DLA88 and DRB1) were amplified and sequenced from the dogs in each group. Similarly, regions of 3 genes associated with the innate immune system (TLR5, NOD2, and ATG16L1), which have been linked to inflammatory bowel disease, were amplified and sequenced...
August 2017: American Journal of Veterinary Research
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