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Climacteric

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https://www.readbyqxmd.com/read/29676234/low-dose-of-acacetin-promotes-breast-cancer-mcf-7-cells-proliferation-through-the-activation-of-erk-pi3k-akt-signaling-pathway
#1
Huanhuan Ren, Jun Ma, Lingling Si, Boxue Ren, Xiaoyu Chen, Dan Wang, Wenjin Hao, Xuexi Tang, Defang Li, Qiusheng Zheng
Background Phytoestrogens has been proposed as a replaceable medicine for climacteric hormone replacement therapy, according to EP3138562, WO/2017/019213 and US5516528. However, recent studies showed that phytoestrogens might promote the proliferation of breast cancer cells and that is associated with their estrogenic activity. Acacetin, as one phytoestrogen, has been reported to exhibit estrogenic activity. But the effects of Acacetin on breast cancer cells proliferation have not been explored Objective In this study, we evaluated the effects of acacetin on breast cancer MCF-7 cells proliferation and explored its possible mechanism...
April 20, 2018: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29673828/decision-making-for-the-treatment-of-climacteric-symptoms-using-the-menopause-rating-scale
#2
Juan Enrique Blümel, Eugenio Arteaga, Joaquín Parra, Carolina Monsalve, Valentina Reyes, María Soledad Vallejo, Rosa Chea
OBJECTIVE: The Menopause Rating Scale (MRS) is one of the most frequently used instruments to evaluate menopausal symptoms; however, no cut-off score is given that would indicate the need for treatment. Our goal was to determine such a cut-off score on the MRS, using as a standard a woman's own perception of her need for treatment in relation to the severity of her symptoms. MATERIAL AND METHODS: The sample comprised 427 healthy women aged 40-59 years who were not taking hormonal treatment...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29668349/climacteric-women-at-work-what-lurks-behind-poor-occupational-quality-of-life
#3
Tatjana Gazibara, Biljana Rancic, Sanja Radovanovic, Ilma Kurtagic, Selmina Nurkovic, Nikolina Kovacevic, Jelena Dotlic
Physical and psychological changes during menopausal transition may affect various aspects of everyday functioning including women's work ability and work productivity. Presence of menopausal symptoms has been well-acknowledged to negatively affect quality of life (QOL). However, data on factors associated with occupational QOL among women at this period of life are lacking. The authors' purpose in this study was to evaluate factors affecting occupational QOL in a sample of employed mid-life women who are experiencing menopause...
April 18, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29617343/postharvest-monitoring-of-tomato-ripening-using-the-dynamic-laser-speckle
#4
Piotr Mariusz Pieczywek, Małgorzata Nowacka, Magdalena Dadan, Artur Wiktor, Katarzyna Rybak, Dorota Witrowa-Rajchert, Artur Zdunek
The dynamic laser speckle (biospeckle) method was tested as a potential tool for the assessment and monitoring of the maturity stage of tomatoes. Two tomato cultivars—Admiro and Starbuck—were tested. The process of climacteric maturation of tomatoes was monitored during a shelf life storage experiment. The biospeckle phenomena were captured using 640 nm and 830 nm laser light wavelength, and analysed using two activity descriptors based on biospeckle pattern decorrelation—C4 and ε...
April 4, 2018: Sensors
https://www.readbyqxmd.com/read/29606425/physicochemical-and-nutritional-characteristics-of-banana-flour-during-ripening
#5
Ana Campuzano, Cristina M Rosell, Fabiola Cornejo
Banana flour has been recognized as functional ingredient, owing to its healthy nutritional pattern. Nevertheless, unripe and ripe banana flours show different characteristics and scarce information is available about changes undergone during banana ripening. This study evaluates the changes on physiochemical (chemical composition, hydration properties, rheological properties and structural characteristic) and nutritional (resistant starch content, phenolic compound and antioxidant activity) characteristics of banana flour at the initial four ripening stages...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29600446/a-simple-and-useful-method-to-apply-exogenous-no-gas-to-plant-systems-bell-pepper-fruits-as-a-model
#6
José M Palma, Carmelo Ruiz, Francisco J Corpas
Nitric oxide (NO) is involved many physiological plant processes, including germination, growth and development of roots, flower setting and development, senescence, and fruit ripening. In the latter physiological process, NO has been reported to play an opposite role to ethylene. Thus, treatment of fruits with NO may lead to delay ripening independently of whether they are climacteric or nonclimacteric. In many cases different methods have been reported to apply NO to plant systems involving sodium nitroprusside, NONOates, DETANO, or GSNO to investigate physiological and molecular consequences...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29582398/the-synthetic-steroid-tibolone-decreases-reactive-gliosis-and-neuronal-death-in-the-cerebral-cortex-of-female-mice-after-a-stab-wound-injury
#7
Andrea Crespo-Castrillo, Natalia Yanguas-Casás, Maria Angeles Arevalo, Iñigo Azcoitia, George E Barreto, Luis M Garcia-Segura
Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29574324/transcript-analyses-of-ethylene-pathway-genes-during-ripening-of-chinese-jujube-fruit
#8
Zhong Zhang, Jian Huang, Xingang Li
The fruit of Chinese jujube (Ziziphus jujuba Mill.) is immensely popular worldwide, while its fleshy fruit has a very short shelf life and suffers serious postharvest damage. The fruit has been controversially classified as non-climacteric, though the mechanisms underlying its ripening behavior, particularly the role of ethylene, have remained unclear. In this study, low and stable ethylene production was detected during ripening of Z. jujuba 'Dongzao' fruit, with production increasing at the full maturity stage...
March 16, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29573436/effects-of-ethrel-1-mcp-and-modified-atmosphere-packaging-on-the-quality-of-wonderful-pomegranates-during-cold-storage
#9
Mónika Valdenegro, Camila Huidobro, Liliam Monsalve, Maricarmen Bernales, Lida Fuentes, Ricardo Simpson
BACKGROUND: Pomegranate (Punica granatum) is a non-climacteric fruit susceptible to chilling injury (CI) at temperatures below 5 °C. To understand the influences of ethylene and modified atmosphere on CI physiological disorders of pomegranate, the exogenous ethrel (0.5, 1, and 1.5 μg L-1 ) treatments, 1-methylcyclopropene (1-MCP) (1 μL L-1 ) exposure, packaging in modified atmosphere (MAP: XTend ™ bags), a MAP/1-MCP combination, and packaging in macro-perforated bags (MPB) were applied...
March 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29562897/comparative-transcriptome-analysis-reveals-distinct-ethylene-independent-regulation-of-ripening-in-response-to-low-temperature-in-kiwifruit
#10
William O Asiche, Oscar W Mitalo, Yuka Kasahara, Yasuaki Tosa, Eric G Mworia, Willis O Owino, Koichiro Ushijima, Ryohei Nakano, Kentaro Yano, Yasutaka Kubo
BACKGROUND: Kiwifruit are classified as climacteric since exogenous ethylene (or its analogue propylene) induces rapid ripening accompanied by ethylene production under positive feedback regulation. However, most of the ripening-associated changes (Phase 1 ripening) in kiwifruit during storage and on-vine occur largely in the absence of any detectable ethylene. This ripening behavior is often attributed to basal levels of system I ethylene, although it is suggested to be modulated by low temperature...
March 21, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29523717/polyamines-regulate-strawberry-fruit-ripening-by-aba-iaa-and-ethylene
#11
Jiaxuan Guo, Shufang Wang, XiaoYang Yu, Rui Dong, Yuzhong Li, Xurong Mei, Yuanyue Shen
Polyamines (PAs) participate in many plant growth and developmental processes, including fruit ripening. However, it is not clear whether PAs play a role in the ripening of strawberry (Fragaria ananassa), a model non-climacteric plant. Here, we found that the content of the PA spermine (Spm) increased more sharply after the onset of fruit coloration than did that of the PAs putrescine (Put) or spermidine (Spd). Spm dominance in ripe fruit resulted from abundant transcripts of a strawberry S-adenosyl-L-methionine decarboxylase gene (FaSAMDC), which encodes an enzyme that generates a residue needed for PA biosynthesis...
March 9, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29515596/genomic-sequencing-of-japanese-plum-prunus-salicina-lindl-mutants-provides-a-new-model-for-rosaceae-fruit-ripening-studies
#12
Angel Fernandez I Marti, Christopher A Saski, George A Manganaris, Ksenija Gasic, Carlos H Crisosto
It has recently been described that the Japanese plum "Santa Rosa" bud sport series contains variations in ripening pattern: climacteric, suppressed-climacteric and non-climacteric types. This provides an interesting model to study the role of ethylene and other key mechanisms governing fruit ripening, softening and senescence. The aim of the current study was to investigate such differences at the genomic level, using this series of plum bud sports, with special reference to genes involved in ethylene biosynthesis, signal transduction, and sugar metabolism...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29509601/climacteric-related-symptoms-in-menopause-transition-and-beyond-a-prospective-19-year-follow-up-study-on-previously-hysterectomized-women
#13
Riina Katainen, Janne R Engblom, Päivi Polo-Kantola
OBJECTIVE: Only a few extended follow-up studies have investigated the natural progress of climacteric-related symptoms. The results have been conflicting. Thus, our aim was to evaluate, through a 19-year longitudinal study, whether these symptoms decrease or disappear as time elapses after menopause. METHODS: Our study was a prospective follow-up survey of 65 hysterectomized peri or postmenopausal women. The women were interviewed at the baseline, and at 6 and 19 years thereafter...
March 5, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29508091/current-treatment-options-headache-related-to-menopause-diagnosis-and-management
#14
REVIEW
Clinton G Lauritsen, Abigail L Chua, Stephanie J Nahas
PURPOSE OF REVIEW: Menopause is a life-changing event in numerous ways. Many women with migraine hold hope that the transition to the climacteric state will coincide with a cessation or improvement of migraine. This assumption is based mainly on common lay perceptions as well as assertions from many in the healthcare community. Unfortunately, evidence suggests this is far from the rule. Many women turn to a general practitioner or a headache specialist for prognosis and management. A natural instinct is to manipulate the offending agent, but in some cases, this approach backfires, or the concern for adverse events outweighs the desire for a therapeutic trial, and other strategies must be pursued...
March 6, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29500922/electrodermal-response-to-auditory-stimuli-in-relation-to-menopausal-transition-period
#15
Ashwini Kishan, Nikitha Marakur, Shailaja Moodithaya, Amrit M Mirajkar
BACKGROUND: Menopause-associated estrogen deficiency results in climacteric symptoms like vasomotor, psychological and sleep disturbances that cause a decline in the quality of life. Electrodermal activity (EDA), a psychophysiological measure, reflects sympathetic activity, which provides information associated with individual's emotions, phobias, arousal, cognition and stress. The study compared electrodermal response to auditory stimuli between postmenopausal and perimenopausal women with and without symptoms and also correlated the association of scores of the menopausal transition symptoms with indices of EDA...
March 28, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29419673/aromatherapy-for-managing-menopausal-symptoms-a-protocol-for-systematic-review-and-meta-analysis
#16
Jiae Choi, Hye Won Lee, Ju Ah Lee, Hyun-Ja Lim, Myeong Soo Lee
BACKGROUND: Aromatherapy is often used as a complementary therapy for women's health. This systematic review aims to evaluate the therapeutic effects of aromatherapy as a management for menopausal symptoms. METHODS: Eleven electronic databases will be searched from inception to February 2018. Randomized controlled trials that evaluated any type of aromatherapy against any type of control in individuals with menopausal symptoms will be eligible. The methodological quality will be assessed using the Cochrane risk of bias tool...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29410369/active-packaging-from-chitosan-titanium-dioxide-nanocomposite-film-for-prolonging-storage-life-of-tomato-fruit
#17
Patinya Kaewklin, Ubonrat Siripatrawan, Anawat Suwanagul, Youn Suk Lee
The feasibility of active packaging from chitosan (CS) and chitosan containing nanosized titanium dioxide (CT) to maintain quality and extend storage life of climacteric fruit was investigated. The CT nanocomposite film and CS film were fabricated using a solution casting method and used as active packaging to delay ripening process of cherry tomatoes. Changes in firmness, weight loss, a*/b* color, lycopene content, total soluble solid, ascorbic acid, and concentration of ethylene and carbon dioxide of the tomatoes packaged in CT film, CS film, and control (without CT or CS films) were monitored during storage at 20°C...
February 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29409850/efficacy-and-safety-of-pueraria-candollei-var-mirifica-airy-shaw-suvat-niyomdham-for-menopausal-women-a-systematic-review-of-clinical-trials-and-the-way-forward
#18
Chuenjid Kongkaew, Norman C Scholfield, Teerapon Dhippayom, Piyameth Dilokthornsakul, Surasak Saokaew, Nathorn Chaiyakunapruk
ETHNOPHARMACOLOGICAL RELEVANCE: Pueraria candollei var. mirifica (Airy Shaw & Suvat.) Niyomdham (commonly termed P. mirifica, PM) growing in upland Thailand has a long history as a postmenopausal rejuvenant therapy for indigenants. Its amelioration of menopause symptoms in clinical trials was assessed. MATERIALS AND METHODS: International and Thai databases were searched from inception to February 2017. Clinical trials investigating effects of PM menopausal or postmenopausal women were included...
February 6, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#19
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29401281/exogenous-strigolactone-interacts-with-abscisic-acid-mediated-accumulation-of-anthocyanins-in-grapevine-berries
#20
Manuela Ferrero, Chiara Pagliarani, Ondrej Novák, Alessandra Ferrandino, Francesca Cardinale, Ivan Visentin, Andrea Schubert
Besides signalling to soil organisms, strigolactones (SL) control above- and below-ground morphology, in particular shoot branching. Furthermore, SL interact with stress responses, possibly thanks to a cross-talk with the abscisic acid (ABA) signal. In grapevine (Vitis vinifera L.), ABA drives the accumulation of anthocyanins over the ripening season. In this study, we investigated the effects of treatment with a synthetic strigolactone analogue, GR24, on anthocyanin accumulation in grape berries, in presence or absence of exogenous ABA treatment...
February 1, 2018: Journal of Experimental Botany
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