Yongli Pan, Wenqiang Xin, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa-Wagner, Stefan T Gerner, Sabine E Huber, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Thorsten R Doeppner
BACKGROUND: Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as hallmarks of inflammation. The nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA with over 200 nucleotides, exerts an indispensable impact on regulating both LD agglomeration and autophagy in multiple neurological disorders. However, knowledge as to how NEAT1 modulates the formation of LD and associated signaling pathways is limited...
January 12, 2024: Cellular and Molecular Life Sciences: CMLS