keyword
https://read.qxmd.com/read/38343745/unraveling-neat1-s-complex-role-in-lung-cancer-biology-a-comprehensive-review
#21
REVIEW
Md Sadique Hussain, Obaid Afzal, Gaurav Gupta, Ahsas Goyal, Waleed Hassan Almalki, Imran Kazmi, Sami I Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Neelam Kukreti, Amlan Chakraborty, Sachin Kumar Singh, Kamal Dua
This review delves into the pivotal role of the long non-coding RNA NEAT1 in cancer biology, particularly in lung cancer (LC). It emphasizes NEAT1's unique subcellular localization and active involvement in gene regulation and chromatin remodeling. The review highlights NEAT1's impact on LC development and progression, including cell processes such as proliferation, migration, invasion, and resistance to therapy, positioning it as a potential diagnostic marker and therapeutic target. The complex web of NEAT1's regulatory interactions with proteins and microRNAs is explored, alongside challenges in targeting it therapeutically...
2024: EXCLI Journal
https://read.qxmd.com/read/38332041/publisher-correction-p53-induces-formation-of-neat1-lncrna-containing-paraspeckles-that-modulate-replication-stress-response-and-chemosensitivity
#22
Carmen Adriaens, Laura Standaert, Jasmine Barra, Mathilde Latil, Annelien Verfaillie, Peter Kalev, Bram Boeckx, Paul W G Wijnhoven, Enrico Radaelli, William Vermi, Eleonora Leucci, Gaëlle Lapouge, Benjamin Beck, Joost van den Oord, Shinichi Nakagawa, Tetsuro Hirose, Anna A Sablina, Diether Lambrechts, Stein Aerts, Cédric Blanpain, Jean-Christophe Marine
No abstract text is available yet for this article.
February 8, 2024: Nature Medicine
https://read.qxmd.com/read/38308547/inhibition-of-pyroptosis-of-renal-tubular-epithelial-cells-by-puerarin-via-regulation-of-lncrna-neat1-ameliorating-chronic-renal-failure
#23
JOURNAL ARTICLE
Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan
INTRODUCTION: Chronic kidney disease (CKD) is one of the major chronic human diseases worldwide. Puerarin, extensively used in traditional Chinese medicine, has shown favorable clinical effects in treating CKD. Here, we aimed to elucidate the mechanism by which puerarin alleviates CKD. METHODS: We constructed an animal model of CKD and intragastrically administered 400 mg/kg puerarin to the rat models. The extent of kidney injury was evaluated by performing hematoxylin and eosin staining...
January 2024: Iranian Journal of Kidney Diseases
https://read.qxmd.com/read/38299506/the-traces-of-dysregulated-lncrnas-associated-cerna-axes-in-retinoblastoma-a-systematic-scope-review
#24
JOURNAL ARTICLE
Kourosh Shahraki, Amin Najafi, Vida Ilkhani Pak, Kianoush Shahraki, Paria Ghasemi Boroumand, Roghayeh Sheervalilou
PURPOSE: Long non-coding RNAs are an essential component of competing endogenous RNA regulatory axes and play their role by sponging microRNAs and interfering with the regulation of gene expression. Because of the broadness of competing endogenous RNA interaction networks, they may help investigate treatment targets in complicated disorders. METHODS: This study performed a systematic scoping review to assess verified loops of competing endogenous RNAs in retinoblastoma, emphasizing the competing endogenous RNAs axis related to long non-coding RNAs...
February 1, 2024: Current Eye Research
https://read.qxmd.com/read/38253310/quercetin-modulates-expression-of-serum-exosomal-long-noncoding-rna-neat1-to-regulate-the-mir-129-5p-bdnf-axis-and-attenuate-cognitive-impairment-in-diabetic-mice
#25
JOURNAL ARTICLE
Hui Wang, Narayanan Jayasankar, Tamilanban Thamaraikani, Patrik Viktor, Mohamed Mohany, Salim S Al-Rejaie, Hasan Khalid Alammar, Enaam Anad, Farah Alhili, Sinan F Hussein, Ali H Amin, Natrayan Lakshmaiya, Muhammad Ahsan, Abolfazl Bahrami, Reza Akhavan-Sigari
AIMS: Cognitive impairment poses a considerable health challenge in the context of type 2 diabetes mellitus (T2DM), emphasizing the need for effective interventions. This study delves into the therapeutic efficacy of quercetin, a natural flavonoid, in mitigating cognitive impairment induced by T2DM in murine models. MATERIALS AND METHODS: Serum exosome samples were obtained from both T2DM-related and healthy mice for transcriptome sequencing, enabling the identification of differentially expressed mRNAs and long noncoding RNAs (lncRNAs)...
January 20, 2024: Life Sciences
https://read.qxmd.com/read/38232183/lncrna-neat1-aggravates-human-microvascular-endothelial-cell-injury-by-inhibiting-the-apelin-nrf2-ho-1-signalling-pathway-in-type-2-diabetes-mellitus-with-obstructive-sleep-apnoea
#26
JOURNAL ARTICLE
Kai Chen, Baiqing Ou, Quan Huang, Daqing Deng, Yi Xiang, Fang Hu
Long noncoding RNAs (lncRNAs) regulate the progression of type 2 diabetes mellitus complicated with obstructive sleep apnoea (T2DM-OSA). However, the role of the lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) in T2DM-OSA remains unknown. This study aimed to reveal the function of NEAT1 in T2DM-OSA and the underlying mechanism. KKAy mice were exposed to intermittent hypoxia (IH) or intermittent normoxia to generate a T2DM-OSA mouse model. HMEC-1 cells were treated with high glucose (HG) and IH to construct a T2DM-OSA cell model...
December 2024: Epigenetics: Official Journal of the DNA Methylation Society
https://read.qxmd.com/read/38230183/retracted-neat1-sirna-packed-with-chitosan-nanoparticles-regulates-the-development-of-colon-cancer-cells-via-lncrna-neat1-mir-377-3p-axis
#27
BioMed Research International
[This retracts the article DOI: 10.1155/2021/5528982.].
2024: BioMed Research International
https://read.qxmd.com/read/38220208/icariin-regulates-emt-and-stem-cell-like-character-in-breast-cancer-through-modulating-lncrna-neat1-tgf%C3%AE-smad2-signaling-pathway
#28
JOURNAL ARTICLE
Bo Song, Fuxia Wei, Jiehao Peng, Xiuhong Wei, Mingran Liu, Zhongbiao Nie, Yanmiao Ma, Tao Peng
Metastases and drug resistance are the major risk factors associated with breast cancer (BC), which is the most common type of tumor affecting females. Icariin (ICA) is a traditional Chinese medicine compound that possesses significant anticancer properties. Long non-coding RNAs (lncRNAs) are involved in a wide variety of biological and pathological processes and have been shown to modulate the effectiveness of certain drugs in cancer. The purpose of this study was to examine the potential effect of ICA on epithelial mesenchymal transition (EMT) and stemness articulation in BC cells, as well as the possible relationship between its inhibitory action on EMT and stemness with the NEAT1/TGFβ/SMAD2 pathway...
January 13, 2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38218038/neat1-in-inflammatory-infectious-diseases-an-integrated-perspective-on-molecular-modulation
#29
REVIEW
Waleed Hassan Almalki
The long non-coding RNA (lncRNA), NEAT1, has emerged as a central figure in the intricate network of molecular regulators in inflammatory infectious diseases (IIDs). The review initiates a comprehensive exploration of NEAT1's multifaceted roles and molecular interactions in the context of these complex diseases. The study begins by acknowledging the global health burden of IIDs, underscoring the urgency for innovative insights into their pathogenesis and therapeutic avenues. NEAT1 is introduced as a pivotal lncRNA with growing relevance in immune responses and inflammatory processes...
November 20, 2023: Pathology, Research and Practice
https://read.qxmd.com/read/38212456/knockdown-of-neat1-prevents-post-stroke-lipid-droplet-agglomeration-in-microglia-by-regulating-autophagy
#30
JOURNAL ARTICLE
Yongli Pan, Wenqiang Xin, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa-Wagner, Stefan T Gerner, Sabine E Huber, Ertugrul Kilic, Dirk M Hermann, Mathias Bähr, Hagen B Huttner, Thorsten R Doeppner
BACKGROUND: Lipid droplets (LD), lipid-storing organelles containing neutral lipids like glycerolipids and cholesterol, are increasingly accepted as hallmarks of inflammation. The nuclear paraspeckle assembly transcript 1 (NEAT1), a long non-coding RNA with over 200 nucleotides, exerts an indispensable impact on regulating both LD agglomeration and autophagy in multiple neurological disorders. However, knowledge as to how NEAT1 modulates the formation of LD and associated signaling pathways is limited...
January 12, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38203310/long-non-coding-rnas-bridging-cancer-associated-thrombosis-and-clinical-outcome-of-ovarian-cancer-patients
#31
JOURNAL ARTICLE
Inês Soares Marques, Valéria Tavares, Joana Savva-Bordalo, Mariana Rei, Joana Liz-Pimenta, Inês Guerra de Melo, Joana Assis, Deolinda Pereira, Rui Medeiros
Ovarian cancer (OC) and venous thromboembolism (VTE) have a close relationship, in which tumour cells surpass the haemostatic system to drive cancer progression. Long non-coding RNAs (lncRNAs) have been implicated in VTE pathogenesis, yet their roles in cancer-associated thrombosis (CAT) and their prognostic value are unexplored. Understanding how these lncRNAs influence venous thrombogenesis and ovarian tumorigenesis may lead to the identification of valuable biomarkers for VTE and OC management. Thus, this study evaluated the impact of five lncRNAs, namely MALAT1, TUG1, NEAT1, XIST and MEG8, on a cohort of 40 OC patients...
December 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38189925/deep-conservation-and-unexpected-evolutionary-history-of-neighboring-lncrnas-malat1-and-neat1
#32
JOURNAL ARTICLE
Forrest Weghorst, Martí Torres Marcén, Garrison Faridi, Yuh Chwen G Lee, Karina S Cramer
Long non-coding RNAs (lncRNAs) have begun to receive overdue attention for their regulatory roles in gene expression and other cellular processes. Although most lncRNAs are lowly expressed and tissue-specific, notable exceptions include MALAT1 and its genomic neighbor NEAT1, two highly and ubiquitously expressed oncogenes with roles in transcriptional regulation and RNA splicing. Previous studies have suggested that NEAT1 is found only in mammals, while MALAT1 is present in all gnathostomes (jawed vertebrates) except birds...
January 8, 2024: Journal of Molecular Evolution
https://read.qxmd.com/read/38180752/mettl3-dependent-n6-methyladenosine-modification-is-involved-in-berberine-mediated-neuroprotection-in-ischemic-stroke-by-enhancing-the-stability-of-neat1-in-astrocytes
#33
JOURNAL ARTICLE
Junya Hu, Huijie Duan, Junqing Zou, Wangli Ding, Ziqiao Wei, Qiang Peng, Zhongyuan Li, Rui Duan, Jianguo Sun, Junrong Zhu
Ischemic stroke (IS) is one of the principal causes of disability and death worldwide. Berberine (BBR), derived from the traditional Chinese herbal medicine Huang Lian, has been reported to inhibit the progression of stroke, but the specific mechanism whereby BBR modulates the progression of ischemic stroke remains unclear. N6-methyladenosine (m6A) modification is the most typical epigenetic modification of mRNA post-transcriptional modifications, among which METTL3 is the most common methylation transferase...
January 4, 2024: Aging
https://read.qxmd.com/read/38178210/pirna-hsa_pir_019949-promotes-chondrocyte-anabolic-metabolism-by-inhibiting-the-expression-of-lncrna-neat1
#34
JOURNAL ARTICLE
Xinhai Zhang, Xuyi Wang, Fengbin Yu, Chenglong Wang, Jianping Peng, Chuandong Wang, Xiaodong Chen
BACKGROUND: Osteoarthritis is a prevalent degenerative joint condition typically found in individuals who are aged 50 years or older. In this study, the focus is on PIWI-interacting RNA (piRNA), which belongs to a category of small non-coding RNAs. These piRNAs play a role in the regulation of gene expression and the preservation of genomic stability. The main objective of this research is to examine the expression of a specific piRNA called hsa_piR_019949 in individuals with osteoarthritis, to understand its impact on chondrocyte metabolism within this condition...
January 4, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38177287/the-roles-of-long-noncoding-rna-neat1-in-cardiovascular-diseases
#35
REVIEW
Xiaoying Jiang, Mingjuan Zhang
The morbidity of cardiovascular diseases (CVDs) gradually increases worldwide. Long noncoding RNAs (lncRNAs) are a large class of non-(protein)-coding RNAs with lengths beyond 200 nucleotides. Increasing evidence suggests that lncRNA NEAT1 plays important roles in the pathogenesis of CVDs, such as myocardial infarction, heart failure, myocardial ischemia-reperfusion (I/R) injury, atherosclerosis, hypertension, cardiomyopathy, and others. We summarized the current studies of NEAT1 in CVDs, which shed light on the understanding of the molecular mechanisms of CVDs and understanding the therapeutic potential of NEAT1...
January 4, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38153328/molecular-mechanism-of-wilms-tumor-1-associated-protein-in-diabetes-related-dry-eye-disease-by-mediating-m6a-methylation-modification-of-lncrna-neat1
#36
JOURNAL ARTICLE
Chen Guo, Mingyi Yu, Jinghua Liu, Zhe Jia, Hui Liu, Shaozhen Zhao
Dry eye disease (DED) is often secondary to diabetes mellitus (DM). We explored the action of Wilms tumor 1-associated protein (WTAP) in DM-DED via lncRNA NEAT1 m6A methylation. DM-DED mouse models were treated with sh-WTAP/sh-NEAT1 plasmid, followed by assessment of corneal epithelial damage/histopathological changes. HCE-2 cells were exposed to hyperosmotic conditions to establish in vitro DED models and treated with oe-NEAT1/sh-NEAT1/sh-WTAP/nigericin (an NLRP3 inflammasome inducer). Cell viability/apoptosis were evaluated by CCK-8/TUNEL...
December 28, 2023: Journal of Drug Targeting
https://read.qxmd.com/read/38137519/vinorelbine-alters-lncrna-expression-in-association-with-egfr-mutational-status-and-potentiates-tumor-progression-depending-on-nsclc-cell-lines-genetic-profile
#37
JOURNAL ARTICLE
Hasan Alsharoh, Paul Chiroi, Andreea Nutu, Lajos Raduly, Oana Zanoaga, Ioana Berindan-Neagoe
Lung cancer remains the leading cause of cancer-related mortality worldwide, with non-small cell lung cancer (NSCLC) as the most common type. In addition, NSCLC has a high mortality rate and an overall adverse patient outcome. Although significant improvements have been made in therapeutic options, effectiveness is still limited in late stages, so the need for a better understanding of the genomics events underlying the current therapies is crucial to aid future drug development. Vinorelbine (VRB) is an anti-mitotic chemotherapy drug (third-generation vinca alkaloid) used to treat several malignancies, including NSCLC...
December 13, 2023: Biomedicines
https://read.qxmd.com/read/38137512/tanshinone-iia-facilitates-efficient-cartilage-regeneration-under-inflammatory-factors-caused-stress-via-upregulating-lncrna-neat1_2
#38
JOURNAL ARTICLE
Jingjing Sun, Wei Chen, Zheng Zhou, Xin Chen, You Zuo, Jiaqian He, Hairong Liu
(1) Background: Osteoarthritis (OA) is a crippling condition characterized by chondrocyte dedifferentiation, cartilage degradation, and subsequent cartilage defects. Unfortunately, there is a lack of effective medicines to facilitate the repair of cartilage defects in OA patients. In this study, we investigated the role of lncRNA NEAT1_2 in maintaining the chondrocyte phenotype and identified tanshinone IIA(TAN) as a natural medicine that enhances NEAT1_2 levels, resulting in efficient cartilage regeneration under inflammatory cytokines...
December 12, 2023: Biomedicines
https://read.qxmd.com/read/38137449/purpl-and-neat1-long-non-coding-rnas-are-modulated-in-vascular-smooth-muscle-cell-replicative-senescence
#39
JOURNAL ARTICLE
Clara Rossi, Marco Venturin, Jakub Gubala, Angelisa Frasca, Alberto Corsini, Cristina Battaglia, Stefano Bellosta
Cellular senescence is characterized by proliferation and migration exhaustion, senescence-associated secretory phenotype (SASP), and oxidative stress. Senescent vascular smooth muscle cells (VSMCs) contribute to cardiovascular diseases and atherosclerotic plaque instability. Since there are no unanimously agreed senescence markers in human VSMCs, to improve our knowledge, we looked for new possible senescence markers. To this end, we first established and characterized a model of replicative senescence (RS) in human aortic VSMCs...
December 6, 2023: Biomedicines
https://read.qxmd.com/read/38115130/bioinformatics-analysis-of-ferroptosis-related-genes-and-immune-cell-infiltration-in-non-alcoholic-fatty-liver-disease
#40
JOURNAL ARTICLE
Huan Zhang, Malina Axinbai, Yuqing Zhao, Jiaoyang Wei, Tongshuo Qu, Jingmin Kong, Yongqiang He, Liping Zhang
BACKGROUND: The morbidity and mortality rates of patients with non-alcoholic fatty liver disease (NAFLD) have been steadily increasing in recent years. Previous studies have confirmed the important role of ferroptosis in NAFLD development; however, the precise mechanism through which ferroptosis influences NAFLD occurrence remains unclear. The present study aimed to identify and validate ferroptosis-related genes involved in NAFLD pathogenesis and to investigate the underlying molecular mechanisms of NAFLD...
December 19, 2023: European Journal of Medical Research
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