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https://www.readbyqxmd.com/read/28060565/paraspeckles-as-rhythmic-nuclear-mrna-anchorages-responsible-for-circadian-gene-expression
#1
Manon Torres, Denis Becquet, Marie-Pierre Blanchard, Séverine Guillen, Bénédicte Boyer, Mathias Moreno, Jean-Louis Franc, Anne-Marie François-Bellan
Circadian clocks regulate rhythmic gene expression levels by means of mRNA oscillations that are mainly driven by post-transcriptional regulation. We identified a new post-transcriptional mechanism, which involves nuclear bodies called paraspeckles. Major components of paraspeckles including the long noncoding RNA Neat1, which is the structural component, and its major protein partners, as well as the number of paraspeckles, follow a circadian pattern in pituitary cells. Paraspeckles are known to retain within the nucleus RNAs containing inverted repeats of Alu sequences...
January 6, 2017: Nucleus
https://www.readbyqxmd.com/read/28054653/the-long-non-coding-rna-neat1-is-responsive-to-neuronal-activity-and-is-associated-with-hyperexcitability-states
#2
Guy Barry, James A Briggs, Do Won Hwang, Sam P Nayler, Patrick R J Fortuna, Nicky Jonkhout, Fabien Dachet, Jesper L V Maag, Pieter Mestdagh, Erin M Singh, Lotta Avesson, Dominik C Kaczorowski, Ezgi Ozturk, Nigel C Jones, Irina Vetter, Luis Arriola-Martinez, Jianfei Hu, Gloria R Franco, Victoria M Warn, Andrew Gong, Marcel E Dinger, Frank Rigo, Leonard Lipovich, Margaret J Morris, Terence J O'Brien, Dong Soo Lee, Jeffrey A Loeb, Seth Blackshaw, John S Mattick, Ernst J Wolvetang
Despite their abundance, the molecular functions of long non-coding RNAs in mammalian nervous systems remain poorly understood. Here we show that the long non-coding RNA, NEAT1, directly modulates neuronal excitability and is associated with pathological seizure states. Specifically, NEAT1 is dynamically regulated by neuronal activity in vitro and in vivo, binds epilepsy-associated potassium channel-interacting proteins including KCNAB2 and KCNIP1, and induces a neuronal hyper-potentiation phenotype in iPSC-derived human cortical neurons following antisense oligonucleotide knockdown...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034643/the-long-non-coding-rna-neat1-interacted-with-mir-101-modulates-breast-cancer-growth-by-targeting-ezh2
#3
Ke Qian, Gao Liu, Zhonghua Tang, Yibo Hu, Yu Fang, Zonglin Chen, Xundi Xu
Nuclear enriched abundant transcript 1 (NEAT1), an important cancer-associated long non-coding RNA (lncRNA), contributes to the development and progression of several cancers. An increased expression of NEAT1 was observed in cancers including bladder cancer, lung cancer and breast cancer (BC). However, the exact effect of NEAT1 in BC progression and the underlying molecular mechanisms are still unknown up to now. Here, we investigated the detailed role of NEAT1 in human BC cell lines and clinical tumor samples in order to validate the function of this molecule...
December 26, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28013491/lncrna-neat1-impacts-cell-proliferation-and-apoptosis-of-colorectal-cancer-via-regulation-of-akt-signaling
#4
Wei Peng, Zhuo Wang, Hong Fan
Long noncoding RNA (lncRNA) have been reported to modulate oncogenesis and be used to be target for tumor. The role of lncRNA NEAT1 (nuclear paraspeckle assembly transcript 1, Gene ID: 283131) in colorectal cancer (CRC) keeps unknown. This work was to investigate the pattern of lncRNA NEAT1 (NEAT1) expression in CRC and its functional value and biological significance. NEAT1 expression was analyzed in 56 cancer tissues and cell lines in CRC cases. Results showed that NEAT1 was significantly overexpressed in CRC cells and tissues...
December 24, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28000845/long-non-coding-rna-neat1-promotes-malignant-progression-of-thyroid-carcinoma-by-regulating-mirna-214
#5
Jian-Hua Li, Su-Qin Zhang, Xing-Guang Qiu, Shui-Jun Zhang, Shou-Hua Zheng, Dan-Hua Zhang
The long non‑coding RNA nuclear enrich abundant transcript 1 (NEAT1) has been identified to be carcinogenic in various cancers and elevated NEAT1 expression was tightly linked to tumorigenesis and progression. However, the mechanism has not been revealed in progression of thyroid cancer. Tumor xenograft mouse model was established and tumor size was evaluated. Arg‑1, NEAT1 and miR‑214 expression in CBMs, TAMs, BMDMs and RAW 264.7 cell lines were detected. TPC‑1 cells were subjected to si‑NEAT1 transfection in vitro for cell viability study...
December 14, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27926523/long-non-coding-rna-neat1-overexpression-is-associated-with-poor-prognosis-in-cancer-patients-a-systematic-review-and-meta-analysis
#6
Chao Yang, Zhuo Li, Yajun Li, Rui Xu, Yongfeng Wang, Yu Tian, Wei Chen
OBJECTIVES: Long non-coding RNAs (lncRNAs) are playing important roles in cancer progression and metastasis. Recent studies have demonstrated that the lncRNA, nuclear paraspeckle assembly transcript 1 (NEAT1), was aberrantly up-regulated in various types of cancers and was reported to be associated with unfavorable prognosis in cancer patients. This study examined the relationship between NEAT1 and relevant clinical outcomes. RESULTS: A total of 1354 patients from 11 eligible studies were included in the meta-analysis...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27888106/long-non-coding-rna-neat1-facilitates-pancreatic-cancer-progression-through-negative-modulation-of-mir-506-3p
#7
Bo Huang, Chuan Liu, Qiong Wu, Jing Zhang, Qinghua Min, Tianle Sheng, Xiaozhong Wang, Yeqing Zou
Recently, long non-coding RNAs (lncRNAs) have been shown to have critical regulatory roles in tumourigenesis. Increasing evidence has suggested that lncRNA NEAT1 has been implicated in various types of human cancer. However, the potential biological roles and regulatory mechanisms of NEAT1 in pancreatic cancer (PC) remains unclear. Here, we found that the expression level of NEAT1 was higher in PC tissues compared to the corresponding non-tumor tissues. Besides, our findings indicate that high NEAT1 expression level is closely correlated with tumor progression and poor survival in PC patients...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27878295/silencing-of-the-long-non-coding-rna-neat1-suppresses-glioma-stem-like-properties-through-modulation-of-the-mir-107-cdk6-pathway
#8
Xiaoli Yang, Zheng Xiao, Xiaowei Du, Lina Huang, Ganqin Du
Developing novel strategies against glioma remains a significant challenge. Long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) significantly contributes to the progression of many human cancers, while glioma stem cells (GSCs) are believed to be responsible for tumor progression. However, whether NEAT1 alters the stem-like properties of GSC cells remains unknown. Using microbeads, CD133+ cells were isolated and were found to possess glioma stem cell properties. Using siRNA, NEAT1 was knocked down in the sorted CD133+ U87 glioma cells...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/27857134/germline-encoded-neutralization-of-a-staphylococcus-aureus-virulence-factor-by-the-human-antibody-repertoire
#9
Yik Andy Yeung, Davide Foletti, Xiaodi Deng, Yasmina Abdiche, Pavel Strop, Jacob Glanville, Steven Pitts, Kevin Lindquist, Purnima D Sundar, Marina Sirota, Adela Hasa-Moreno, Amber Pham, Jody Melton Witt, Irene Ni, Jaume Pons, David Shelton, Arvind Rajpal, Javier Chaparro-Riggers
Staphylococcus aureus is both an important pathogen and a human commensal. To explore this ambivalent relationship between host and microbe, we analysed the memory humoral response against IsdB, a protein involved in iron acquisition, in four healthy donors. Here we show that in all donors a heavily biased use of two immunoglobulin heavy chain germlines generated high affinity (pM) antibodies that neutralize the two IsdB NEAT domains, IGHV4-39 for NEAT1 and IGHV1-69 for NEAT2. In contrast to the typical antibody/antigen interactions, the binding is primarily driven by the germline-encoded hydrophobic CDRH-2 motifs of IGHV1-69 and IGHV4-39, with a binding mechanism nearly identical for each antibody derived from different donors...
November 18, 2016: Nature Communications
https://www.readbyqxmd.com/read/27822425/neat1-regulates-pancreatic-cancer-cell-growth-invasion-and-migration-though-mircrorna-335-5p-c-met-axis
#10
Jia Cao, Yi Zhang, Jiachun Yang, Sijia He, Mingming Li, Shiyan Yan, Ying Chen, Chunying Qu, Leiming Xu
NEAT1 has been reported to affect cancer progression, which was subsequently confirmed in multiple cancers. Hsa-miRNA-335-5p (miR-335-5p) has recently been identified as an anticancer agent in various organs. However, the relationship between NEAT1 and miR-335-5p remains poorly understood. In this study, we investigated the effects of NEAT1 and miR-335-5p on development of pancreatic cancer. The ectopic expression of miR-335-5p in pancreatic cancer cell lines significantly suppressed cell growth by inhibiting c-met...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27814882/commentary-on-the-oestrogen-receptor-alpha-regulated-lncrna-neat1-is-a-critical-modulator-of-prostate-cancer-chakravarty-d-sboner-a-nair-ss-giannopoulou-e-li-r-hennig-s-mosquera-jm-pauwels-j-park-k-kossai-m-macdonald-ty-fontugne-j-erho-n-vergara-ia-ghadessi
#11
https://www.readbyqxmd.com/read/27801298/dysregulation-of-mitotic-machinery-genes-precedes-genome-instability-during-spontaneous-pre-malignant-transformation-of-mouse-ovarian-surface-epithelial-cells
#12
Ulises Urzúa, Sandra Ampuero, Katherine F Roby, Garrison A Owens, David J Munroe
BACKGROUND: Based in epidemiological evidence, repetitive ovulation has been proposed to play a role in the origin of ovarian cancer by inducing an aberrant wound rupture-repair process of the ovarian surface epithelium (OSE). Accordingly, long term cultures of isolated OSE cells undergo in vitro spontaneous transformation thus developing tumorigenic capacity upon extensive subcultivation. In this work, C57BL/6 mouse OSE (MOSE) cells were cultured up to passage 28 and their RNA and DNA copy number profiles obtained at passages 2, 5, 7, 10, 14, 18, 23, 25 and 28 by means of DNA microarrays...
October 25, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27783096/neat1-modulates-herpes-simplex-virus-1-replication-by-regulating-viral-gene-transcription
#13
Ziqiang Wang, Ping Fan, Yiwan Zhao, Shikuan Zhang, Jinhua Lu, Weidong Xie, Yuyang Jiang, Fan Lei, Naihan Xu, Yaou Zhang
Nuclear paraspeckle assembly transcript 1 (NEAT1) is the crucial structural platform of paraspeckles, which is one type of nuclear bodies. As a stress-induced lncRNA, the expression of NEAT1 increases in response to viral infection, but little is known about the role of NEAT1 or paraspeckles in the replication of herpes simplex virus-1 (HSV-1). Here, we demonstrate that HSV-1 infection increases NEAT1 expression and paraspeckle formation in a STAT3-dependent manner. NEAT1 and other paraspeckle protein components, P54nrb and PSPC1, can associate with HSV-1 genomic DNA...
October 25, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27774948/-alterations-and-clinical-signifecance-of-exosome-containing-innate-immunity-related-lncrnas-in-patients-of-hemorrhagic-fever-with-renal-syndrome
#14
Xuyang Zheng, Chuantao Ye, Jieru Zhao, Peiyu Bian, Ying Zhang, Zhansheng Jia
Objective To observe the alterations of innate immunity related long non-coding RNAs (lncRNAs) in exosomes extracted from the plasma of hemorrhagic fever with renal syndrome (HFRS) patients, and analyze their relationship with the disease stage and severity. Methods Exosomes were extracted from the plasma samples of HFRS patients, healthy controls and recovered HFRS patients. Transmission electronic microscopy and Western blotting were performed to confirm the efficiency of the extraction. lncRNA profiles in the different groups were determined by high-throughput sequencing...
November 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27700225/neat1-containing-paraspeckles-central-hubs-in-stress-response-and-tumor-formation
#15
Carmen Adriaens, Jean-Christophe Marine
No abstract text is available yet for this article.
October 4, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27665741/paraspeckles-modulate-the-intranuclear-distribution-of-paraspeckle-associated-ctn-rna
#16
Aparna Anantharaman, Mahdieh Jadaliha, Vidisha Tripathi, Shinichi Nakagawa, Tetsuro Hirose, Michael F Jantsch, Supriya G Prasanth, Kannanganattu V Prasanth
Paraspeckles are sub-nuclear domains that are nucleated by long noncoding RNA Neat1. While interaction of protein components of paraspeckles and Neat1 is understood, there is limited information on the interaction of non-structural RNA components with paraspeckles. Here, by varying paraspeckle number and size, we investigate how paraspeckles influence the nuclear organization of their non-structural RNA component Ctn RNA. Our results show that Ctn RNA remains nuclear-retained in the absence of intact paraspeckles, suggesting that they do not regulate nuclear retention of Ctn RNA...
September 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27664948/overexpression-of-long-noncoding-rna-neat1-promotes-cell-proliferation-invasion-and-migration-in-endometrial-endometrioid-adenocarcinoma
#17
Zhiguo Li, Dianjun Wei, Chao Yang, Honggang Sun, Tao Lu, Defeng Kuang
Long noncoding RNAs (lncRNAs) are emerging as important modulators in the biological processes and tumorigenesis. However, whether lncRNAs are involved in endometrial endometrioid adenocarcinoma (EEC) remains unclear. In the present study, we explored the expression pattern, clinical significance and biological function of nuclear enriched abundant transcript 1 (NEAT1) in EEC. The expression levels of NEAT1 were elevated in EEC tissues and cell lines, and higher expression levels of NEAT1 were positively correlated with FIGO stage and lymph node metastasis...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27646274/structural-super-resolution-microscopy-analysis-of-paraspeckle-nuclear-body-organization
#18
Jason A West, Mari Mito, Satoshi Kurosaka, Toru Takumi, Chiharu Tanegashima, Takeshi Chujo, Kaori Yanaka, Robert E Kingston, Tetsuro Hirose, Charles Bond, Archa Fox, Shinichi Nakagawa
Paraspeckles are nuclear bodies built on the long noncoding RNA Neat1, which regulates a variety of physiological processes including cancer progression and corpus luteum formation. To obtain further insight into the molecular basis of the function of paraspeckles, we performed fine structural analyses of these nuclear bodies using structural illumination microscopy. Notably, paraspeckle proteins are found within different layers along the radially arranged bundles of Neat1 transcripts, forming a characteristic core-shell spheroidal structure...
September 26, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27646270/shedding-light-on-paraspeckle-structure-by-super-resolution-microscopy
#19
Shi-Bin Hu, Run-Wen Yao, Ling-Ling Chen
The nuclear body paraspeckle is built on the lncRNA Neat1 and plays important roles in gene regulation. In this issue, West et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201601071) use super-resolution structured illumination microscopy to show that paraspeckles are organized in a core-shell spheroidal structure composed of Neat1 and seven proteins.
September 26, 2016: Journal of Cell Biology
https://www.readbyqxmd.com/read/27633334/long-non-coding-rna-expression-profile-in-vulvar-squamous-cell-carcinoma-and-its-clinical-significance
#20
Sha Ni, Xiaoyu Zhao, Ling Ouyang
Researchers have recently demonstrated the key role of long non-coding RNAs (lncRNAs) in regulating embryogenesis and gene expression. However, the exact mechanism used by lncRNAs in carcinogenesis is still unclear. In particular, studies regarding the role of lncRNAs in vulvar squamous cell carcinomas (VSCCs) are limited. Using microarray analysis, the genome-wide expression profile of lncRNAs was investigated in four paired VSCCs and adjacent normal vulvar tissues. Accordingly, several novel lncRNA candidates (HOAIR, MALAT1, MEG3, NEAT1, MIR31HG and LINC00478) were chosen for further study and real-time reverse transcription PCR (RT-PCR) was used to confirm the expression levels among 35 tissue samples...
November 2016: Oncology Reports
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