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Darja Deobald, Lorenz Adrian, Christian Schöne, Michael Rother, Gunhild Layer
The biological formation of methane (methanogenesis) is a globally important process, which is exploited in biogas technology, but also contributes to global warming through the release of a potent greenhouse gas into the atmosphere. The last and methane-releasing step of methanogenesis is catalysed by the enzyme methyl-coenzyme M reductase (MCR), which carries several exceptional posttranslational amino acid modifications. Among these, a 5-C-(S)-methylarginine is located close to the active site of the enzyme...
May 9, 2018: Scientific Reports
Ian A Kieffer, Robert J Allen, Jordan L Fernandez, Jackson L Deobald, Brena L Thompson, Jacob D Wimpenny, Zachariah M Heiden
Fluorescent dyes have been widely utilized as chemical sensors and in photodynamic therapy, but exploitation of their redox-active nature in chemical reactions has remained mostly unexplored. This report describes the isolation of a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based radical. The redox-active nature of the BODIPY compound can be utilized in combination with a guanidine center, the basicity of which can be manipulated by greater than 14 pKa units, to promote the conversion of protons and electrons into H-atoms for transfer to substrate molecules...
March 19, 2018: Angewandte Chemie
Ulrich Leicht-Deobald, Heike Bruch, Luisa Bönke, Amie Stevense, Yan Fan, Malek Bajbouj, Simone Grimm
Early life stress (ELS) affects stress- reactivity via limbic brain regions implicated such as hippocampus and amygdala. Social support is a major protective factor against ELS effects, while subjects with ELS experience reportedly perceive less of it in their daily life. The workplace, where most adults spend a substantial amount of time in their daily lives, might serve as a major resource for social support. Since previous data demonstrated that social support attenuates stress reactivity, we here used a psychosocial stress task to test the hypothesis that work-related social support modulates the effects of ELS...
December 15, 2017: Brain Imaging and Behavior
Deborah A Dos Santos, Anna Maria Deobald, Vivian E Cornelio, Roberta M D Ávila, Renata C Cornea, Gilberto C R Bernasconi, Marcio W Paixão, Paulo C Vieira, Arlene G Corrêa
Cathepsin L plays important roles in physiological processes as well as in the development of many pathologies. Recently the attentions were turned to its association with tumor progress what makes essential the development of more potent and selective inhibitors. In this work, epoxipeptidomimetics were investigated as new cathepsin inhibitors. This class of compounds is straightforward obtained by using a green one-pot asymmetric epoxidation/Passerini 3-MCR. A small library of 17 compounds was evaluated against cathepsin L, and among them LSPN423 showed to be the most potent...
September 1, 2017: Bioorganic & Medicinal Chemistry
Bruna de Oliveira Bastos, Gabriel Antônio Deobald, Thiarles Brun, Valéria Dal Prá, Emanuele Junges, Raquel C Kuhn, Aniela Kempka Pinto, Marcio A Mazutti
In this study, a bioherbicide was produced by solid-state fermentation (SSF) using Diaporthe sp. Adjuvants were employed in a formulation to enhance the herbicidal activity towards the target (Cucumis sativus). The study was divided into two steps: (1) the fermentation condition for bioherbicide production was assessed; (2) evaluation of different formulations containing palm oil, Tween(®) 80 and Span(®) 80, in order to increase phytotoxicity. In step 1, the maximum herbicidal activity (1.23% of the leaves had lesions) was obtained at 25 °C, moisture content of 50 wt%, supplemented with 10 wt% of corn steep liquor and soybean bran and inoculum density of 15 wt%...
June 2017: 3 Biotech
Mohammad Ibrahim, Niaz Muhammad, Muhammad Naeem, Anna Maria Deobald, Jean Paul Kamdem, Joao Batista Teixeira Rocha
The amine based diselenide, (Z)-N-(4-methylbenzylidene)-1-(2-((2-(1-((E)-4-methyl benzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethanamine ethyl)phenyl) diselanyl) phenyl) ethylimino) methyl)phenol (Compound A) an organoselenium compound that can mimic endogenous antioxidant enzymes, such as glutathione peroxidase (GPx), and diphenyl diselenide (PhSe)2 were tested against lipid peroxidation induced by sodium nitroprusside (SNP) and Fe(II) in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical (DPPH) and glutathione peroxidase (GPx) like antioxidant activities with H2O2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize thiols were evaluated...
August 2015: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Leandro R S Camargo, Julio Zukerman-Schpector, Anna M Deobald, Antonio L Braga, Edward R T Tiekink
In the title compound, C23H21N3Se, the C-bound phenyl ring is almost coplanar with the central five-membered ring [dihedral angle = 2.84 (10)°], but the N-bound benzene ring is inclined [dihedral angle = 47.52 (10)°]. The dihedral angle between the Se-bound rings is 69.24 (9)°. An intra-molecular Se⋯N inter-action of 3.0248 (15) Å is noted. In the crystal, C-H⋯π inter-actions connect mol-ecules into double layers that stack along the a axis with no directional inter-actions between them.
March 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
Leandro R S Camargo, Julio Zukerman-Schpector, Anna M Deobald, Antonio L Braga, Edward R T Tiekink
In the title compound, C21H17N3OSe, the dihedral angles between the central five-membered ring and the C- and N-bound rings are 17.89 (10) and 42.35 (10)°, respectively, indicating the mol-ecule is twisted. The dihedral angle between the Se-bound rings is 85.36 (10)°. A close intra-molecular Se⋯O contact of 2.8507 (13) Å is noted. In the crystal, C-H⋯O, C-H⋯N and C-H⋯π inter-actions lead to the formation of supra-molecular layers parallel to (011); these stack with no specific inter-molecular inter-actions between them...
March 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
Leandro R S Camargo, Julio Zukerman-Schpector, Anna M Deobald, Antonio L Braga, Edward R T Tiekink
Two independent mol-ecules, A and B, comprise the asymmetric unit of the title compound, C20H21N3OSe. While the benzene ring directly bound to the central triazole ring is inclined to the same extent in both mol-ecules [dihedral angles = 40.41 (12) (mol-ecule A) and 44.14 (12)° (B)], greater differences are apparent in the dihedral angles between the Se-bound rings, i.e. 74.28 (12) (mol-ecule A) and 89.91 (11)° (B). Close intra-molecular Se⋯N inter-actions of 2.9311 (18) (mol-ecule A) and 2.9482 (18) Å (B) are noted...
March 1, 2015: Acta Crystallographica. Section E, Crystallographic Communications
Raymond G Deobald, Eva S W Cheng, Yoo-Joung Ko, Frances C Wright, Paul J Karanicolas
BACKGROUND: After surgical resection of pancreatic adenocarcinoma, most patients will develop recurrence within 2 years. Intense follow-up is often recommended; however, its impact on survival is unknown. Patient and clinician attitudes towards follow-up were qualitatively assessed along with the perceived benefits and challenges. METHODS: A semi-structured interview guide was developed. Purposive sampling identified patients who were in active surveillance or had developed recurrence...
May 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Leslie J Donato, Gayle R Deobald, Amy M Wockenfus, Jean M Hornseth, Amy K Saenger, Brad S Karon
OBJECTIVES: The aim of this study was to assess the performance of two point of care (POC) devices for capillary lipid screening in fasting and post-prandial adults. DESIGN AND METHODS: Fasting and post-prandial capillary whole blood samples collected from 57 adult donors were analyzed simultaneously on Cholestech LDX Lipid Profile (Alere San Diego, Inc., San Diego, CA) cassettes and CardioChek Lipid Panel (Polymer Technology Systems, Indianapolis, IN) strips. Paired serum samples were collected from the same donors and analyzed with CDC-certified methods for total cholesterol, high density lipoprotein cholesterol (HDL-C) and non-blanked triglycerides...
February 2015: Clinical Biochemistry
Brad S Karon, Chanse T Blanshan, Gayle R Deobald, Amy M Wockenfus
BACKGROUND: More stringent accuracy guidelines for hospital-use glucose meters have recently been published, but it remains unclear whether glucose meters can meet these accuracy guidelines when measurement is performed on critically ill patients with fresh whole blood samples. MATERIALS AND METHODS: We performed a retrospective evaluation of a conventional (Roche Diagnostics [Indianapolis, IN] AccuChek® Inform) and a newer-generation (Nova Biomedical [Waltham, MA] StatStrip®) glucose system by comparing paired (drawn within 5 min of each other) whole blood glucose meter and laboratory serum glucose values obtained from intensive care unit (ICU) patients...
December 2014: Diabetes Technology & Therapeutics
Julie Hallet, Francis S W Zih, Raymond G Deobald, Adena S Scheer, Calvin H L Law, Natalie G Coburn, Paul J Karanicolas
BACKGROUND: Pancreatic fistula (PF) remains a common source of morbidity following pancreaticoduodenectomy (PD). Despite numerous studies, the optimal method of pancreatic remnant reconstruction is controversial. This study examines the hypothesis that pancreaticogastrostomy (PG) is associated with a lower risk for PF after PD compared with pancreaticojejunostomy (PJ). METHODS: Five electronic databases and the grey literature were searched for randomized controlled trials (RCTs) comparing PJ and PG after PD...
February 2015: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Mohammad Ibrahim, Waseem Hassan, Javed Anwar, Anna Maria Deobald, Jean Paul Kamdem, Diogo Onofre Souza, Joao Batista Teixeira Rocha
Free radical scavenging and antioxidant activities of 1-(2-(2-(2-(1-aminoethyl)phenyl)diselanyl)phenyl)ethanamine (compound A) and diphenyl diselenide (PhSe)2 were examined and compared for inhibition of Fe(II) and sodium nitroprusside (SNP) stimulated lipid peroxidation in rat brain, interaction with 1,1-diphenyl-2-picrylhydrazyl (DPPH) stable free radical and their glutathione peroxidase (GPx) like antioxidant activities with H2O2 or tBuOOH as substrates and with PhSH as thiol co-substrates as well as their ability to oxidize mono- and di-thiols were also evaluated...
June 2014: Toxicology in Vitro: An International Journal Published in Association with BIBRA
Ray Deobald, Peter Graham, Jennifer Chad, Carlo Di Gregorio, Jennifer Johnstone, Lloyd Balbuena, Chris Kenyon, Mark Lees
OBJECTIVE: To evaluate current colorectal cancer (CRC) screening practices in Saskatchewan and identify barriers to screening with the goal of improving current practice. DESIGN: Survey of family physicians. SETTING: Saskatchewan. PARTICIPANTS: A total of 773 family physicians were surveyed. MAIN OUTCOME MEASURES: Demographic characteristics, individual screening practices, and perceived barriers to screening...
December 2013: Canadian Family Physician Médecin de Famille Canadien
P J Kononoff, P J Defoor, M J Engler, R S Swingle, S T James, H M Deobald, J L Deobald, F L S Marquess
A total of 4,178 steers (mean initial BW = 403.9 ± 16.04 kg) were used to test the interactive effects, if any, of leptin R25C genotypes (CC, CT, or TT) and zilpaterol hydrochloride (ZH) feeding duration on growth performance and carcass traits. Steers were blocked by arrival at the feed yard, genotyped for the leptin SNP, allotted to genotype-specific pens (90 steers/pen), and assigned randomly within genotype and block to 0 or 21 d of dietary ZH. All pens within a block were slaughtered on the same day (132...
October 2013: Journal of Animal Science
Marcos Raniel Straliotto, Jade de Oliveira, Gianni Mancini, Afonso C D Bainy, Alexandra Latini, Anna Maria Deobald, João B T Rocha, Andreza Fabro de Bem
Oxidative modifications of low-density lipoproteins (LDLs) have a determinant role in atherogenesis and the study of agents that can modulate LDL oxidation is of pharmacological and therapeutic significance. Therefore, the aim of this study was to evaluate the antioxidant effect of the disubstituted diaryl diselenides, p-methoxyl-diphenyl diselenide (p-CH(3)O-C(6)H(4)Se)(2) (DM) and p-chloro-diphenyl diselenide (p-Cl-C(6)H(4)Se)(2) (DC), on Cu(2+)-induced LDL oxidation. Both compounds caused a dose-dependent inhibition of human serum and isolated LDL oxidation evidenced by the increasing of the lag phase of lipid peroxidation and decreased the lipid oxidation rate (V(max))...
March 12, 2013: European Journal of Pharmaceutical Sciences
Mohammad Ibrahim, Waseem Hassan, Daiane Francine Meinerz, Matheus Dos Santos, Claudia V Klimaczewski, Anna M Deobald, Maricilia S Costa, Cristina W Nogueira, Nilda B V Barbosa, Joao B T Rocha
Diorganoyl dichalcogenide compouds can have antioxidant activity in different in vitro and in vivo models. Here, we have compared the potential antioxidant activity of 1-dinaphthyl diselenide (1-NapSe)(2), 2-dinaphthyl diselenide (2-NapSe)(2), 1-dinaphthyl distelluride (1-NapTe)(2), 2-dinaphthyl ditelluride (2-NapTe)(2) with their well-studied analogs diphenyl diselenide ((PhSe)(2)) and diphenyl telluride ((PhTe)(2)). (PhSe)(2), (PhTe)(2), and naphthalene analogs-inhibited Fe(II)-induced lipid peroxidation, catalytically decomposed hydrogen peroxide and oxidized thiols, such as dithiothreitol (DTT), Cysteine (CYS), dimercaptopropionic acid (DMPS), and thiophenol (PhSH)...
December 2012: Molecular and Cellular Biochemistry
Anna Maria Deobald, Arlene G Corrêa, Daniel G Rivera, Márcio Weber Paixão
An eco-friendly synthesis of highly functionalized epoxides and their incorporation into an organocatalytic multicomponent approach are reported. For this, a modified class of diarylprolinol silyl ethers was designed to enable high catalytic activity in an environmentally benign solvent system. The one-pot procedure showed great efficiency in promoting stereoselective multicomponent transformations in a tandem, 'green' fashion. Because of its non-residual, efficient and selective character, this synthetic design shows promise for large-scale applications in both diversity and target-oriented syntheses...
October 14, 2012: Organic & Biomolecular Chemistry
Keun Seok Seo, Jong Wan Kim, Joo Youn Park, Austin K Viall, Scott S Minnich, Harold N Rohde, Darren R Schnider, Seung Yong Lim, Joon Bae Hong, B Joseph Hinnebusch, Jason L O'Loughlin, Claudia F Deobald, Gregory A Bohach, Carolyn J Hovde, Scott A Minnich
A comprehensive TnphoA mutant library was constructed in Yersinia pestis KIM6 to identify surface proteins involved in Y. pestis host cell invasion and bacterial virulence. Insertion site analysis of the library repeatedly identified a 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein (Ilp), similar to the Gram-negative intimin/invasin family of surface proteins. Deletion mutants of ilp were generated in Y. pestis strains KIM5(pCD1(+)) Pgm(-) (pigmentation negative)/, KIM6(pCD1(-)) Pgm(+), and CO92...
October 2012: Infection and Immunity
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