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Nutrition aging longevity lifestyle

Rachel A Brewer, Victoria K Gibbs, Daniel L Smith
Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the ability to target the aging process can facilitate improved healthspan and potentially lifespan. Lack of adequate glucoregulatory control remains a recurrent theme accompanying aging and chronic disease, while numerous longevity interventions result in maintenance of glucoregulatory control. In this review, we propose targeting glucose metabolism to enhance regulatory control as a means to ameliorate the aging process...
October 27, 2016: Nutrition and Healthy Aging
Xu Jiang He, Lin Bin Zhou, Qi Zhong Pan, Andrew B Barron, Wei Yu Yan, Zhi Jiang Zeng
Specialized castes are considered a key reason for the evolutionary and ecological success of the social insect lifestyle. The most essential caste distinction is between the fertile queen and the sterile workers. Honeybee (Apis mellifera) workers and queens are not genetically distinct, rather these different phenotypes are the result of epigenetically regulated divergent developmental pathways. This is an important phenomenon in understanding the evolution of social insect societies. Here, we studied the genomic regulation of the worker and queen developmental pathways, and the robustness of the pathways by transplanting eggs or young larvae to queen cells...
December 27, 2016: Molecular Ecology
Andreas W Schoenenberger, Franco Muggli, Gianfranco Parati, Augusto Gallino, Georg Ehret, Paolo M Suter, Renate Schoenenberger-Berzins, Therese J Resink, Paul Erne
INTRODUCTION: Increased longevity and consequent major changes in demographics and population lifestyles necessitate new approaches to reduce the burden of ageing-related diseases (including cardiovascular disease) and maintain an optimal quality of life. This study aims to examine and longitudinally follow health status and disease risk factors in a Swiss rural cohort, evaluating all health-related research and practice disciplines to assure development of new implementable and successful preventive strategies for healthy ageing...
November 28, 2016: BMJ Open
Carlos López-Otín, Lorenzo Galluzzi, José M P Freije, Frank Madeo, Guido Kroemer
Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. The main features of the "westernized" lifestyle, including hypercaloric nutrition and sedentariness, can accelerate aging as they have detrimental metabolic consequences...
August 11, 2016: Cell
Masato Iwabu, Toshimasa Yamauchi, Miki Okada-Iwabu, Takashi Kadowaki
Given that appropriate control of responses of the body to nutritional status is assumed to modulate the pace of aging, thus prolonging lifespan and maintaining youth in humans, expectations are mounting worldwide for modalities targeting the pathways in metabolic regulation for healthy longevity. Of these, this review focuses attention on adiponectin-targeted therapy and discusses milestones in this approach, which include the discovery of the ability of adiponectin to protect against lifestyle-related diseases, identification of its receptors (AdipoRs), elucidation of AdipoR-mediated signaling pathways that promote healthy longevity and acquisition of small-molecule AdipoR agonist, and explores future prospects on adiponectin-targeted therapy...
March 2016: Clinical Calcium
Paolo Mazzola, Stefania Maria Lorenza Rimoldi, Paolo Rossi, Marianna Noale, Federico Rea, Carla Facchini, Stefania Maggi, Giovanni Corrao, Giorgio Annoni
Italy, a Southern European country with 60.8 million inhabitants, has the largest proportion of elderly citizens (aged ≥65) in Europe of 21.4%. The aging of the population is due to a number of reasons, such as baby boomers growing old, an increase in longevity, and low birth rate. Although international migration has increased in recent years, the addition of a foreign segment of the population has neither compensated for nor significantly curtailed the aging phenomenon. The impact of aging on the economic sustainability concerns the progressive reduction of the workforce, high incidence of pension spending in the overall resources allocated to welfare, recent reform of the pension system, and the growing issue of "non-self-sufficiency" in the elderly...
June 2016: Gerontologist
Katarzyna Szarc vel Szic, Ken Declerck, Melita Vidaković, Wim Vanden Berghe
The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic factors...
2015: Clinical Epigenetics
V Calabrese, G Scapagnini, S Davinelli, G Koverech, A Koverech, C De Pasquale, A Trovato Salinaro, M Scuto, E J Calabrese, A R Genazzani
Aging process is accompanied by hormonal changes characterized by an imbalance between catabolic hormones, such as cortisol and thyroid hormones which remain stable and hormones with anabolic effects (testosterone, insulin like growth factor-1 (IGF-1) and dehydroepiandrosterone sulphate (DHEAS), that decrease with age. Deficiencies in multiple anabolic hormones have been shown to predict health status and longevity in older persons.Unlike female menopause, which is accompanied by an abrupt and permanent cessation of ovarian function (both folliculogenesis and estradiol production), male aging does not result in either cessation of testosterone production nor infertility...
December 2014: Journal of Cell Communication and Signaling
M Zbeida, R Goldsmith, T Shimony, H Vardi, L Naggan, D R Shahar
BACKGROUND/OBJECTIVES: The Mediterranean diet (MEDDIET) has been shown to be related to longevity. This study aimed to determine the association between adherence to MEDDIET and physical function of older adults in the United-States and Israel. METHODS: Data from the US National Health and Nutrition Survey (NHANES) 1999-2002 and from the Israeli National Health and Nutrition Survey (MABAT ZAHAV) 2005-2006 were used. Participants with nutritional and functional data were included...
April 2014: Journal of Nutrition, Health & Aging
Thomas T Samaras
Most people believe that being taller and heavier is a sign of higher social status and privilege; however, an objective evaluation of the advantages and disadvantages of increased body size (excluding obesity) indicated that shorter, smaller bodies have numerous advantages in terms of health and longevity. With healthful nutrition and lifestyles, and good medical care, shorter people are less likely to suffer from age-related chronic diseases and more likely to reach advanced ages. A variety of biological factors explain the inherent benefits of smaller bodies...
October 2012: Nutrition and Health
Jessica C Kiefte-de Jong, John C Mathers, Oscar H Franco
Healthy longevity is a tangible possibility for many individuals and populations, with nutritional and other lifestyle factors playing a key role in modulating the likelihood of healthy ageing. Nevertheless, studies of effects of nutrients or single foods on ageing often show inconsistent results and ignore the overall framework of dietary habits. Therefore, the use of dietary patterns (e.g. a Mediterranean dietary pattern) and the specific dietary recommendations (e.g. dietary approaches to stop hypertension, Polymeal and the American Healthy Eating Index) are becoming more widespread in promoting lifelong health...
May 2014: Proceedings of the Nutrition Society
Sonya Vasto, Annalisa Barera, Claudia Rizzo, Marta Di Carlo, Calogero Caruso, George Panotopoulos
The Mediterranean diet (Mediet) is an eating pattern characterizing a lifestyle and culture that has been reported to contribute to better health and quality of life. The Mediet reflects food patterns typical of Mediterranean regions, where olive oil plays an essential role in the food pyramid. Olive oil is located in the middle and it is considered the principal source of dietary fat because of its high nutritional quality (particularly extra virgin olive oil). Several studies have shown the effect of the Mediet on healthy status by lowering the rates of coronary heart disease, certain cancers, and some other age-related chronic diseases...
2014: Current Vascular Pharmacology
Susan B Roberts, John Speakman
The United States population is aging rapidly, and understanding the potential impact and feasibility of lifestyle interventions on the aging process is of central importance for addressing future population health and health care costs. This symposium addressed the question of whether caloric restriction may be a feasible strategy to improve human health by reductions in rates of primary and secondary aging in humans, viewed from the perspective of existing data in animal models, and by using emerging data from the human Comprehensive Assessment of Long-Term Reduction in Energy Intake trial, which is a randomized trial of human caloric restriction in free-living men and women...
2013: Advances in Nutrition
Janusz Smigielski, Wojciech Bielecki, Wojciech Drygas
INTRODUCTION: The article presents a selected part of an analysis of health- and lifestyle-related determinants of the longevity of male residents of the city of Łódź. The WHO strategy for the European region assumes that the term' lifestyle' refers to the way of life based on the association between conditions of life understood in a broad sense and individual patterns of behaviour determined by socio-cultural factors and individual features. On this basis, the aim of this study is to identify the multiple statistical relationships on the mortality of men living in Łódź, particularly the influence of the following variables on the probability of survival: age, subjective health assessment, nutritional habits, alcohol consumption and tobacco smoking...
June 2013: International Journal of Occupational Medicine and Environmental Health
Serena Dato, Paolina Crocco, Patrizia D'Aquila, Francesco de Rango, Dina Bellizzi, Giuseppina Rose, Giuseppe Passarino
Oxidative stress is both the cause and consequence of impaired functional homeostasis characterizing human aging. The worsening efficiency of stress response with age represents a health risk and leads to the onset and accrual of major age-related diseases. In contrast, centenarians seem to have evolved conservative stress response mechanisms, probably derived from a combination of a diet rich in natural antioxidants, an active lifestyle and a favorable genetic background, particularly rich in genetic variants able to counteract the stress overload at the level of both nuclear and mitochondrial DNA...
2013: International Journal of Molecular Sciences
P Chedraui, F R Pérez-López
Interactions between genetic (genome) and environmental factors (epigenome) operate during a person's entire lifespan. The aging process is associated with several cellular and organic functional alterations that, at the end, cause multi-organic cell failure. Epigenetic mechanisms of aging are modifiable by appropriate preventive actions mediated by sirtuins, caloric input, diet components, adipose tissue-related inflammatory reactions, and physical activity. The Mediterranean lifestyle has been for many millennia a daily habit for people in Western civilizations living around the Mediterranean sea who worked intensively and survived with very few seasonal foods...
August 2013: Climacteric: the Journal of the International Menopause Society
Anne-Claire Vergnaud, Dora Romaguera, Petra H Peeters, Carla H van Gils, Doris S M Chan, Isabelle Romieu, Heinz Freisling, Pietro Ferrari, Françoise Clavel-Chapelon, Guy Fagherazzi, Laureen Dartois, Kuanrong Li, Kaja Tikk, Manuela M Bergmann, Heiner Boeing, Anne Tjønneland, Anja Olsen, Kim Overvad, Christina C Dahm, Maria Luisa Redondo, Antonio Agudo, María-José Sánchez, Pilar Amiano, María-Dolores Chirlaque, Eva Ardanaz, Kay-Tee Khaw, Nick J Wareham, Francesca Crowe, Antonia Trichopoulou, Philippos Orfanos, Dimitrios Trichopoulos, Giovanna Masala, Sabina Sieri, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-de-Mesquita, Martine M Ros, Anne May, Elisabet Wirfält, Emily Sonestedt, Ingegerd Johansson, Göran Hallmans, Eiliv Lund, Elisabete Weiderpass, Christine L Parr, Elio Riboli, Teresa Norat
BACKGROUND: In 2007, the World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) issued recommendations on diet, physical activity, and weight management for cancer prevention on the basis of the most comprehensive collection of available evidence. OBJECTIVE: We investigated whether concordance with WCRF/AICR recommendations is related to risk of death. DESIGN: The current study included 378,864 participants from 9 European countries enrolled in the European Prospective Investigation into Cancer and Nutrition study...
May 2013: American Journal of Clinical Nutrition
Sarah A McNaughton, David Crawford, Kylie Ball, Jo Salmon
BACKGROUND: Nutrition and physical activity are major determinants of health and quality of life; however, there exists little research focusing on determinants of these behaviours in older adults. This is important, since just as these behaviours vary according to subpopulation, it is likely that the determinants also vary. An understanding of the modifiable determinants of nutrition and physical activity behaviours among older adults to take into account the specific life-stage context is required in order to develop effective interventions to promote health and well-being and prevent chronic disease and improve quality of life...
2012: Health and Quality of Life Outcomes
Sergio Davinelli, D Craig Willcox, Giovanni Scapagnini
Ageing is a challenge for any living organism and human longevity is a complex phenotype. With increasing life expectancy, maintaining long-term health, functionality and well-being during ageing has become an essential goal. To increase our understanding of how ageing works, it may be advantageous to analyze the phenotype of centenarians, perhaps one of the best examples of successful ageing. Healthy ageing involves the interaction between genes, the environment, and lifestyle factors, particularly diet. Besides evaluating specific gene-environment interactions in relation to exceptional longevity, it is important to focus attention on modifiable lifestyle factors such as diet and nutrition to achieve extension of health span...
2012: Immunity & Ageing: I & A
Luxi Ji, Hongdao Meng, Birong Dong
BACKGROUND & AIMS: Older adults are at increased risk for malnutrition. The aim was to investigate the prevalence of and risk factors for poor nutritional status in oldest-old Chinese. METHODS: Community-living Chinese aged 90 and over were included in the study. Nutritional status was evaluated by using the Mini Nutritional Assessment short-form (MNA-SF). Demographic and socioeconomic status, health status, cognitive, behavioral, and lifestyle factors were collected via structured questionnaires during face-to-face interviews...
December 2012: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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