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https://www.readbyqxmd.com/read/29652053/the-interplay-of-nanointerface-curvature-and-calcium-binding-in-weak-polyelectrolyte-coated-nanoparticles
#1
Rikkert J Nap, Estefania Gonzalez Solveyra, Igal Szleifer
When engineering nanomaterials for application in biological systems, it is important to understand how multivalent ions, such as calcium, affect the structural and chemical properties of polymer-modified nanoconstructs. In this work, a recently developed molecular theory was employed to study the effect of surface curvature on the calcium-induced collapse of end-tethered weak polyelectrolytes. In particular, we focused on cylindrical and spherical nanoparticles coated with poly(acrylic acid) in the presence of different amounts of Ca2+ ions...
April 13, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29650676/sodium-bicarbonate-loading-limits-tubular-cast-formation-independent-of-glomerular-injury-and-proteinuria-in-dahl-salt-sensitive-rats
#2
S C Ray, B Patel, D L Irsik, J Sun, H Ocasio, G R Crislip, C H Jin, J K Chen, B Baban, A J Polichnowski, P M O'Connor
Sodium bicarbonate (NaHCO3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the mechanisms mediating this effect remain unclear. The Dahl salt-sensitive (SS) rat develops hypertension and progressive renal injury when fed a high salt diet; however, the effect of alkali loading on kidney injury has never been investigated in this model. We hypothesized that 'NaHCO3 protects from the development of renal injury in Dahl salt-sensitive rats via luminal alkalization which limits the formation of tubular casts, which are a prominent pathological feature in this model...
April 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29648567/salt-sensitivity-of-blood-pressure-is-it-time-to-customize-the-antihypertensive-therapy
#3
Lanfranco D'Elia
No abstract text is available yet for this article.
April 10, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29643251/pharmacological-characterization-of-iw-1973-a-novel-soluble-guanylate-cyclase-stimulator-with-extensive-tissue-distribution-anti-hypertensive-anti-inflammatory-and-anti-fibrotic-effects-in-preclinical-models-of-disease
#4
Jenny V Tobin, Daniel P Zimmer, Courtney Shea, Peter Germano, Sylvie G Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon Jamie Im, James Sheppeck, Joel D Moore, Kristine Sykes, James Wakefield, Renee Sarno, Ali R Banijamali, Albert T Profy, G Todd Milne, Mark G Currie, Jaime L Masferrer
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophosphate (cGMP) upon binding of nitric oxide (NO). Endothelial dysfunction and/or reduced NO signaling have been implicated in cardiovascular disease pathogenesis and complications of diabetes, and have been associated with other disease states and aging. sGC stimulators are small-molecule drugs that bind sGC and enhance NO-mediated cGMP signaling. The pharmacological characterization of IW-1973, a novel clinical-stage sGC stimulator, is described...
April 11, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29626511/rna-sequencing-analysis-of-salt-tolerance-in-soybean-glycine-max
#5
Ailan Zeng, Pengyin Chen, Ken L Korth, Jieqing Ping, Julie Thomas, Chengjun Wu, Subodh Srivastava, Andy Pereira, Floyd Hancock, Kristofor Brye, Jianxin Ma
Salt stress causes foliar chlorosis and scorch, plant stunting, and eventually yield reduction in soybean. There are differential responses, namely tolerance (excluder) and intolerance (includer), among soybean germplasm. However, the genetic and physiological mechanisms for salt tolerance is complex and not clear yet. Based on the results from the screening of the RA-452 x Osage mapping population, two F4:6 lines with extreme responses, most tolerant and most sensitive, were selected for a time-course gene expression study in which the 250 mM NaCl treatment was initially imposed at the V1 stage and continued for 24 h (hrs)...
April 4, 2018: Genomics
https://www.readbyqxmd.com/read/29626011/centromere-transcription-allows-cenp-a-to-transit-from-chromatin-association-to-stable-incorporation
#6
Georg O M Bobkov, Nick Gilbert, Patrick Heun
Centromeres are essential for chromosome segregation and are specified epigenetically by the presence of the histone H3 variant CENP-A. In flies and humans, replenishment of the centromeric mark is uncoupled from DNA replication and requires the removal of H3 "placeholder" nucleosomes. Although transcription at centromeres has been previously linked to the loading of new CENP-A, the underlying molecular mechanism remains poorly understood. Here, we used Drosophila melanogaster tissue culture cells to show that centromeric presence of actively transcribing RNA polymerase II temporally coincides with de novo deposition of dCENP-A...
April 6, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29606219/genetic-mapping-of-a-lobed-leaf-gene-associated-with-salt-tolerance-in-brassica-napus-l
#7
Yan Zhang, Aixia Xu, Lina Lang, Yang Wang, Xia Liu, Fenghao Liang, Bingbing Zhang, Mengfan Qin, Jazira Dalelhan, Zhen Huang
Lobed leaf is a common trait, which is related with photosynthesis and plant stress resistance in crops. In order to fine map and isolate the lobed-leaf gene in Brassica napus, an F2:3 population derived from 2205 (salt tolerance) and 1423 (salt sensitive) was constructed, and the quantitative trait locus (QTL) technology was adopted to identify the QTLs related to lobed leaf formation. As a result, one major QTL was identified on LG10, and two intron polymorphic (IP) markers and one sequence characterized amplified region (SCAR) marker were successfully developed in QTL region...
April 2018: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/29602296/transcriptomic-analysis-reveals-inflammatory-and-metabolic-pathways-which-are-regulated-by-renal-perfusion-pressure-in-the-outer-medulla-of-dahl-s-rats
#8
Louise C Evans, Alex Dayton, Chun Yang, Pengyuan Liu, Theresa Kurth, Kwang Woo Ahn, Steve Komas, Francesco C Stingo, Purushottam W Laud, Marina Vannucci, Mingyu Liang, Allen W Cowley
Studies exploring the development of hypertension have traditionally been unable to distinguish which of the observed changes are underlying causes from those which are a consequence of elevated blood pressure. In this study, a custom designed servo-control system was utilized to precisely control renal perfusion pressure to the left kidney continuously during the development of hypertension in Dahl salt-sensitive rats. In this way, we maintained the left kidney at control blood pressure while the right kidney was exposed to hypertensive pressures...
March 30, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29600538/sb-216763-a-gsk-3%C3%AE-inhibitor-protects-against-aldosterone-induced-cardiac-and-renal-injury-by-activating-autophagy
#9
Yi-De Zhang, Xiao-Jun Ding, Hou-Yong Dai, Wei-Sheng Peng, Nai-Feng Guo, Yuan Zhang, Qiao-Ling Zhou, Xiao-Lan Chen
Cardiovascular and renal inflammation induced by Aldosterone (Aldo) plays a pivotal role in the pathogenesis of hypertension and renal fibrosis. GSK-3β contributes to inflammatory cardiovascular and renal diseases, but its role in Aldo-induced hypertension, and renal damage is not clear. In the present study, rats were treated with Aldo combined with SB-216763 (a GSK-3β inhibitor) for 4 weeks. Hemodynamic, cardiac, and renal parameters were assayed at the indicated time. Here we found that rats treated with Aldo presented cardiac and renal hypertrophy and dysfunction...
March 30, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29595916/the-complement-system-in-hypertension-and-renal-damage-in-the-dahl-ss-rat
#10
Jean F Regal, Connor F Laule, Luke McCutcheon, Kate M Root, Hayley Lund, Shireen Hashmat, David L Mattson
Evidence indicates the immune system is important in development of hypertension and kidney disease. In the Dahl Salt-Sensitive (SS) rat model, lymphocytes play a role in development of hypertension and kidney damage after increased sodium intake. Recent transcriptomic analyses demonstrate upregulation of the innate immune complement system in the kidney of Dahl SS rat fed a high-salt diet, leading us to hypothesize that inhibition of complement activation would attenuate development of hypertension and kidney damage...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29594117/erythrocyte-salt-sedimentation-assay-does-not-predict-response-to-renal-denervation
#11
Oliver Vonend, Ole Martin, Lars C Rump, Patrick Kroepil, Johannes Stegbauer
Renal denervation (RDN) has recently been shown to be effective in patients without antihypertensive medication. However, about 30% of patients do not respond to RDN, and therefore, there exists a need to find predictors of response. Individuals are either salt-sensitive (SS) or non-salt-sensitive (NSS) in terms of their blood pressure (BP) regulation. The sympathetic nervous system can influence water and salt handling. RDN reduces sympathetic drive and has an impact on salt excretion. The present study was conducted to test the influence of salt sensitivity in terms of the BP reducing effect after RDN procedure...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29587643/the-influence-of-host-genotype-and-salt-stress-on-the-seed-endophytic-community-of-salt-sensitive-and-salt-tolerant-rice-cultivars
#12
Denver I Walitang, Chang-Gi Kim, Kiyoon Kim, Yeongyeong Kang, Young Kee Kim, Tongmin Sa
BACKGROUND: Inherent characteristics and changes in the physiology of rice as it attains salt tolerance affect the colonizing bacterial endophytic communities of the rice seeds. These transmissible endophytes also serve as a source of the plant's microbial community and concurrently respond to the host and environmental conditions. This study explores the influence of the rice host as well as the impact of soil salinity on the community structure and diversity of seed bacterial endophytes of rice with varying tolerance to salt stress...
March 27, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29581556/salt-sensitivity-of-blood-pressure-at-age-8-years-in-children-born-preterm
#13
Charlotte A Ruys, Joost Rotteveel, Monique van de Lagemaat, Harrie N Lafeber, Martijn J J Finken
Preterm birth and low birth weight have been associated with an increased risk of hypertension; postnatal growth and dietary salt intake may contribute to these associations. In adults, the change of blood pressure (BP) in response to modifications in salt intake, i.e., salt sensitivity of BP, has been independently associated with cardiovascular disease. Little is known about salt sensitivity in children. We hypothesize that it may partly explain the association between preterm birth and higher BP in later life...
March 27, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29570433/targeted-disruption-of-regulated-endocrine-specific-protein-resp18-in-dahl-ss-mcw-rats-aggravates-salt-induced-hypertension-and-renal-injury
#14
Sivarajan Kumarasamy, Harshal Waghulde, Xi Cheng, Steven T Haller, Blair Mell, Basrur Abhijith, Usman M Ashraf, Ealla Atari, Bina Joe
Hypertension is a classic example of a complex polygenic trait, impacted by quantitative trait loci (QTL) containing candidate genes thought to be responsible for blood pressure (BP) control in mammals. One such mapped locus is on rat chromosome 9, wherein the proof for a positional candidate gene, Regulated Endocrine Specific Protein-18 (Resp18) is currently inadequate. To ascertain the status of Resp18 as a BP QTL, a custom targeted gene disruption model of Resp18 was developed on the Dahl Salt-Sensitive (SS) background...
March 23, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29567533/high-salt-diet-induces-metabolic-alterations-in-multiple-biological-processes-of-dahl-salt-sensitive-rats
#15
Yanjun Wang, Xiangyang Liu, Chen Zhang, Zhengjun Wang
High salt induced renal disease is a condition resulting from the interactions of genetic and dietary factors causing multiple complications. To understand the metabolic alterations associated with renal disease, we comprehensively analyzed the metabonomic changes induced by high salt intake in Dahl salt-sensitive (SS) rats using GC-MS technology and biochemical analyses. Physiological features, serum chemistry, and histopathological data were obtained as complementary information. Our results showed that high salt (HS) intake for 16 weeks caused significant metabolic alterations in both the renal medulla and cortex involving a variety pathways involved in the metabolism of organic acids, amino acids, fatty acids, and purines...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29558753/stimulation-of-intestinal-cl-secretion-through-cftr-by-caffeine-intake-in-salt-sensitive-hypertensive-rats
#16
Xiao Wei, Zongshi Lu, Tao Yang, Peng Gao, Sijiao Chen, Daoyan Liu, Zhiming Zhu
BACKGROUND/AIMS: High salt consumption is a major risk factor for hypertension, and sodium homeostasis is regulated by both intestinal sodium absorption and urinary sodium excretion. Chronic caffeine intake has been reported to attenuate salt-sensitive hypertension by promoting urinary sodium excretion; however, its exact role in intestinal sodium absorption remains unknown. Here, we investigated whether and how chronic caffeine consumption antagonizes salt-sensitive hypertension by inhibiting intestinal sodium absorption...
March 16, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29556499/-in-silico-analysis-of-differential-gene-expression-in-three-common-rat-models-of-diastolic-dysfunction
#17
Raffaele Altara, Fouad A Zouein, Rita Dias Brandão, Saeed N Bajestani, Alessandro Cataliotti, George W Booz
Standard therapies for heart failure with preserved ejection fraction (HFpEF) have been unsuccessful, demonstrating that the contribution of the underlying diastolic dysfunction pathophysiology differs from that of systolic dysfunction in heart failure and currently is far from being understood. Complicating the investigation of HFpEF is the contribution of several comorbidities. Here, we selected three established rat models of diastolic dysfunction defined by three major risk factors associated with HFpEF and researched their commonalities and differences...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29556335/urinary-metabolites-associated-with-blood-pressure-on-a-low-or-high-sodium-diet
#18
Yuan Cheng, Haiying Song, Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R Lanza, Pengyuan Liu, Yong Liu, Purushottam W Laud, Kristie Usa, Yongcheng He, Mingyu Liang
Dietary salt intake has significant effects on arterial blood pressure and the development of hypertension. Mechanisms underlying salt-dependent changes in blood pressure remain poorly understood, and it is difficult to assess blood pressure salt-sensitivity clinically. Methods: We examined urinary levels of metabolites in 103 participants of the Dietary Approaches to Stop Hypertension (DASH)-Sodium trial after nearly 30 days on a defined diet containing high sodium (targeting 150 mmol sodium intake per day) or low sodium (50 mmol per day)...
2018: Theranostics
https://www.readbyqxmd.com/read/29556243/transcriptome-and-cell-physiological-analyses-in-different-rice-cultivars-provide-new-insights-into-adaptive-and-salinity-stress-responses
#19
Elide Formentin, Cristina Sudiro, Giorgio Perin, Samantha Riccadonna, Elisabetta Barizza, Elena Baldoni, Enrico Lavezzo, Piergiorgio Stevanato, Gian Attilio Sacchi, Paolo Fontana, Stefano Toppo, Tomas Morosinotto, Michela Zottini, Fiorella Lo Schiavo
Salinity tolerance has been extensively investigated in recent years due to its agricultural importance. Several features, such as the regulation of ionic transporters and metabolic adjustments, have been identified as salt tolerance hallmarks. Nevertheless, due to the complexity of the trait, the results achieved to date have met with limited success in improving the salt tolerance of rice plants when tested in the field, thus suggesting that a better understanding of the tolerance mechanisms is still required...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29555923/differential-regulation-of-genes-involved-in-root-morphogenesis-and-cell-wall-modification-is-associated-with-salinity-tolerance-in-chickpea
#20
Mayank Kaashyap, Rebecca Ford, Himabindu Kudapa, Mukesh Jain, Dave Edwards, Rajeev Varshney, Nitin Mantri
Salinity is a major constraint for intrinsically salt sensitive grain legume chickpea. Chickpea exhibits large genetic variation amongst cultivars, which show better yields in saline conditions but still need to be improved further for sustainable crop production. Based on previous multi-location physiological screening, JG 11 (salt tolerant) and ICCV 2 (salt sensitive) were subjected to salt stress to evaluate their physiological and transcriptional responses. A total of ~480 million RNA-Seq reads were sequenced from root tissues which resulted in identification of 3,053 differentially expressed genes (DEGs) in response to salt stress...
March 19, 2018: Scientific Reports
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