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https://www.readbyqxmd.com/read/29212900/genome-wide-gene-potassium-interaction-analyses-on-blood-pressure-the-gensalt-study-genetic-epidemiology-network-of-salt-sensitivity
#1
Changwei Li, Jiang He, Jing Chen, Jinying Zhao, Dongfeng Gu, James E Hixson, Dabeeru C Rao, Cashell E Jaquish, Treva K Rice, Yun Ju Sung, Tanika N Kelly
BACKGROUND: Gene-environmental interaction analysis can identify novel genetic factors for blood pressure (BP). We performed genome-wide analyses to identify genomic loci that interact with potassium to influence BP using single-marker (1 and 2 df joint tests) and gene-based tests among Chinese participants of the GenSalt study (Genetic Epidemiology Network of Salt Sensitivity). METHODS AND RESULTS: Among 1876 GenSalt participants, the average of 3 urine samples was used to estimate potassium excretion...
December 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29204082/looking-at-halophytic-adaptation-to-high-salinity-through-genomics-landscape
#2
REVIEW
G C Nikalje, T D Nikam, P Suprasanna
Soil salinity is an important stress factor that limits plant growth and productivity. For a given plant species, it is critical to sense and respond to salt stimuli followed by activation of multitude of mechanisms for plants to survive. Halophytes, the wonders of saline soils, have demonstrated ability to withstand and reproduce in at least 200 mM NaCl concentration, which makes them an ideal system to study mechanism of salt adaptation for imparting salt tolerance in glycophytes. Halophytes and salt sensitive glycophytes adapt different defense strategies towards salinity stress...
December 2017: Current Genomics
https://www.readbyqxmd.com/read/29198596/phenotypic-and-genetic-diversity-of-moroccan-rhizobia-isolated-from-vicia-faba-and-study-of-genes-that-are-likely-to-be-involved-in-their-osmotolerance
#3
Loubna Benidire, Majida Lahrouni, Khalid Daoui, Zain El Abidine Fatemi, Ricardo Gomez Carmona, Michael Göttfert, Khalid Oufdou
Rhizobia are symbiotic nitrogen-fixing bacteria in root nodules of legumes. In Morocco, faba bean (Vicia faba L.), which is the main legume crop cultivated in the country, is often grown in marginal soils of arid and semi-arid regions. This study examines the phenotypic diversity of rhizobia nodulating V. faba isolated from different regions in Morocco for tolerance to some abiotic stresses. A total of 106 rhizobia strains isolated from nodules were identified at the species level by analysing 16S rDNA. Additionally, for selected strains recA, otsA, kup and nodA fragments were sequenced...
November 3, 2017: Systematic and Applied Microbiology
https://www.readbyqxmd.com/read/29192500/comparative-proteomics-of-contrasting-maize-genotypes-provides-insights-into-salt-stress-tolerance-mechanisms
#4
Meijie Luo, Yanxin Zhao, Yuandong Wang, Zi Shi, Panpan Zhang, Yunxia Zhang, Wei Song, Jiuran Zhao
Salt stress is a major abiotic factor limiting maize yield. To characterize the mechanism underlying maize salt tolerance, we compared the seedling root proteomes of salt-tolerant Jing724 and salt-sensitive D9H. The germination rate and growth parameter values (weight and length) were higher for Jing724 than for D9H under saline conditions. Using an iTRAQ-based method, we identified 513 differentially regulated proteins (DRPs), with 83 and 386 DRPs specific to Jing724 and D9H, respectively. In salt-stressed Jing724, the DRPs were primarily associated with the pentose phosphate pathway, glutathione metabolism, and nitrogen metabolism...
December 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29182730/genetic-variation-in-slc8a1-gene-involved-in-blood-pressure-responses-to-acute-salt-loading
#5
Kuo Liu, Zheng Liu, Han Qi, Bin Liu, Jingjing Wu, Yezhou Liu, Jie Zhang, Han Cao, Yuxiang Yan, Yan He, Ling Zhang
BACKGROUND: Salt sensitivity of blood pressure (SSBP) increases the risk of cardiovascular complications, and the heritability of SSBP is about 50% in Chinese population. However, studies identifying genes involved in BP responses to acute sodium loading and diuresis shrinkage are still limited. METHOD: A total of 342 essential hypertensives from Beijing were recruited in our study. A modified Sullivan's acute oral saline load and diuresis shrinkage test was conducted to each individual...
November 22, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/29181013/abiotic-stresses-cause-differential-regulation-of-alternative-splice-forms-of-gata-transcription-factor-in-rice
#6
Priyanka Gupta, Kamlesh K Nutan, Sneh L Singla-Pareek, Ashwani Pareek
The GATA gene family is one of the most conserved families of transcription factors, playing a significant role in different aspects of cellular processes, in organisms ranging from fungi to angiosperms. GATA transcription factors are DNA-binding proteins, having a class IV zinc-finger motif CX2CX17-20CX2C followed by a highly basic region and are known to bind a consensus sequence WGATAR. In plants, GATAs are known to be involved in light-dependent gene regulation and nitrate assimilation. However, a comprehensive analysis of these GATA gene members has not yet been highlighted in rice when subjected to environmental stresses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29179201/alteration-of-tight-junction-protein-expression-in-dahl-salt-sensitive-rat-kidney
#7
Chor Ho Jo, Sua Kim, Il Hwan Oh, Joon-Sung Park, Gheun-Ho Kim
BACKGROUND/AIMS: Altered pressure natriuresis is an important mechanism of hypertension, but it remains elusive at the molecular level. We hypothesized that in the kidney, tight junctions (TJs) may have a role in pressure natriuresis because paracellular NaCl transport affects interstitial hydrostatic pressure. METHODS: To assess the association of salt-sensitive hypertension with altered renal TJ protein expression, Dahl salt-sensitive (SS) and salt-resistant (SR) rats were put on an 8% NaCl-containing rodent diet for 4 weeks...
November 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29151146/mapping-and-confirmation-of-loci-for-salt-tolerance-in-a-novel-soybean-germplasm-fiskeby-iii
#8
Tuyen D Do, Tri D Vuong, David Dunn, Scotty Smothers, Gunvant Patil, Dennis C Yungbluth, Pengyin Chen, Andrew Scaboo, Dong Xu, Thomas E Carter, Henry T Nguyen, J Grover Shannon
The confirmation of a major locus associated with salt tolerance and mapping of a new locus, which could be beneficial for improving salt tolerance in soybean. Breeding soybean for tolerance to high salt conditions is important in some regions of the USA and world. Soybean cultivar Fiskeby III (PI 438471) in maturity group 000 has been reported to be highly tolerant to multiple abiotic stress conditions, including salinity. In this study, a mapping population of 132 F2 families derived from a cross of cultivar Williams 82 (PI 518671, moderately salt sensitive) and Fiskeby III (salt tolerant) was analyzed to map salt tolerance genes...
November 18, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29144825/salt-hypertension-and-immunity
#9
A Justin Rucker, Nathan P Rudemiller, Steven D Crowley
The link between inappropriate salt retention in the kidney and hypertension is well recognized. However, growing evidence suggests that the immune system can play surprising roles in sodium homeostasis, such that the study of inflammatory cells and their secreted effectors has provided important insights into salt sensitivity. As part of the innate immune system, myeloid cells have diverse roles in blood pressure regulation, ranging from prohypertensive actions in the kidney, vasculature, and brain, to effects in the skin that attenuate blood pressure elevation...
November 16, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/29143823/salt-responsive-gut-commensal-modulates-th17-axis-and-disease
#10
Nicola Wilck, Mariana G Matus, Sean M Kearney, Scott W Olesen, Kristoffer Forslund, Hendrik Bartolomaeus, Stefanie Haase, Anja Mähler, András Balogh, Lajos Markó, Olga Vvedenskaya, Friedrich H Kleiner, Dmitry Tsvetkov, Lars Klug, Paul I Costea, Shinichi Sunagawa, Lisa Maier, Natalia Rakova, Valentin Schatz, Patrick Neubert, Christian Frätzer, Alexander Krannich, Maik Gollasch, Diana A Grohme, Beatriz F Côrte-Real, Roman G Gerlach, Marijana Basic, Athanasios Typas, Chuan Wu, Jens M Titze, Jonathan Jantsch, Michael Boschmann, Ralf Dechend, Markus Kleinewietfeld, Stefan Kempa, Peer Bork, Ralf A Linker, Eric J Alm, Dominik N Müller
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (TH17) cells, which can also contribute to hypertension. Induction of TH17 cells depends on gut microbiota; however, the effect of salt on the gut microbiome is unknown. Here we show that high salt intake affects the gut microbiome in mice, particularly by depleting Lactobacillus murinus. Consequently, treatment of mice with L. murinus prevented salt-induced aggravation of actively induced experimental autoimmune encephalomyelitis and salt-sensitive hypertension by modulating TH17 cells...
November 15, 2017: Nature
https://www.readbyqxmd.com/read/29140729/gene-expression-and-gene-associations-during-the-development-of-heart-failure-with-preserved-ejection-fraction-in-the-dahl-salt-sensitive-model-of-hypertension
#11
Jeffrey Yim, Hyokeun Cho, Simon W Rabkin
Gene expression and associations were examined in a model of heart failure with preserved ejection fraction (HFpEF), a condition with minimal effective treatment. Genes with at least two studies showing significant changes in Dahl rat with heart failure were examined by meta-analysis. Significantly increased in expression were iNOS, p47phox, ADM, ANP, OPN, ACE, MCP-1, GP91PHOX, ICAM-1, TGF-β1, CTGF, ET-1, p22phox, ETB, BNP, ETA, MMP13, Col1a1, MMP2, TIMP1, Col3a1, Il-1β, β-MHC, ECE1, MMP14, AGT, and MMP9...
November 15, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29138984/11%C3%AE-hydroxysteroid-dehydrogenases-and-hypertension-in-the-metabolic-syndrome
#12
REVIEW
Matthew A Bailey
The metabolic syndrome describes a clustering of risk factors-visceral obesity, dyslipidaemia, insulin resistance, and salt-sensitive hypertension-that increases mortality related to cardiovascular disease, type 2 diabetes, cancer, and non-alcoholic fatty liver disease. The prevalence of these concurrent comorbidities is ~ 25-30% worldwide, and metabolic syndrome therefore presents a significant global public health burden. Evidence from clinical and preclinical studies indicates that glucocorticoid excess is a key causal feature of metabolic syndrome...
November 14, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29133363/prevalence-of-hypertensive-phenotypes-after-preeclampsia-a-prospective-cohort-study
#13
Agnès Ditisheim, Grégoire Wuerzner, Belen Ponte, Yvan Vial, Olivier Irion, Michel Burnier, Michel Boulvain, Antoinette Pechère-Bertschi
Preeclampsia is associated with increased cardiovascular and renal risk. The aim of this prospective cohort study was to characterize the early postpartum blood pressure (BP) profile after preeclampsia. We enrolled 115 women with preeclampsia and 41 women with a normal pregnancy in a prospective cohort study. At 6 to 12 week postpartum, we assessed the prevalence of different hypertensive phenotypes using 24-hour ambulatory BP monitoring (ABPM), as well as the risk of salt sensitivity and the variability of BP derived from ABPM parameters...
November 13, 2017: Hypertension
https://www.readbyqxmd.com/read/29129584/high-salt-loading-induces-urinary-storage-dysfunction-via-upregulation-of-epithelial-sodium-channel-alpha-in-the-bladder-epithelium-in-dahl-salt-sensitive-rats
#14
Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Yasuhiro Shibata, Shoichi Sasaki, Shinya Ugawa, Takahiro Yasui, Kazunori Kimura
We aimed to investigate whether high salt intake affects bladder function via epithelial sodium channel (ENaC) by using Dahl salt-resistant (DR) and salt-sensitive (DS) rats. Bladder weight of DR + high-salt diet (HS, 8% NaCl) and DS + HS groups were significantly higher than those of DR + normal-salt diet (NS, 0.3% NaCl) and DS + NS groups after one week treatment. We thereafter used only DR + HS and DS + HS group. Systolic and diastolic blood pressures were significantly higher in DS + HS group than in DR + HS group after the treatment period...
October 10, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29128399/nitric-oxide-production-by-glomerular-podocytes
#15
Oleg Palygin, Daria V Ilatovskaya, Vladislav Levchenko, Bradley T Endres, Aron M Geurts, Alexander Staruschenko
Nitric Oxide (NO), a potent vasodilator and vital signaling molecule, has been shown to contribute to the regulation of glomerular ultrafiltration. However, whether changes in NO occur in podocytes during the pathogenesis of salt-sensitive hypertension has not yet been thoroughly examined. We showed here that podocytes produce NO, and further hypothesized that hypertensive animals would exhibit reduced NO production in these cells in response to various paracrine factors, which might contribute to the damage of glomeruli filtration barrier and development of proteinuria...
November 8, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29118017/role-of-immune-factors-in-angiotensin-ii-induced-hypertension-and-renal-damage-in-dahl-salt-sensitive-rats
#16
Brittany Wade, Galina Petrova, David L Mattson
The present study assessed the importance of immunity in AngII (5 ng/kg/min, iv)-mediated hypertension in Dahl Salt Sensitive (SS) rats and SS rats deficient in T- and B-lymphocytes (SS (Rag1-/-)) fed a 0.4% NaCl diet. Baseline mean arterial blood pressure (MAP) was not different between groups. AngII infusion significantly increased MAP in both groups; though MAP increased more rapidly in SS, and the maximal MAP achieved in SS (190±3 mmHg) was significantly greater than that in SS(Rag1-/-) (177±3 mmHg) after 12 days...
November 8, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29105660/erratum-a-high-salt-diet-enhances-leukocyte-adhesion-in-association-with-kidney-injury-in-young-dahl-salt-sensitive-rats
#17
Hidenori Takahashi, Suguru Nakagawa, Yaqiong Wu, Yukari Kawabata, Atsushi Numabe, Yasuo Yanagi, Yasuhiro Tamaki, Yoshio Uehara, Makoto Araie
This corrects the article DOI: 10.1038/hr.2017.31.
November 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29098651/excess-body-weight-insulin-resistance-and-isolated-systolic-hypertension-potential-pathophysiological-links
#18
Lanfranco D'Elia, Pasquale Strazzullo
Isolated systolic hypertension, the most common form of hypertension in the elderly, but also detectable among young and middle-aged subjects, is independently associated with higher risk of cardiovascular events and all-cause mortality. Among various pathophysiological changes associated with aging, excess body weight and insulin resistance may predispose to this type of hypertension. Overweight or frank obesity and their frequent companion insulin resistance could mediate the development of isolated systolic hypertension through increase in the renin-angiotensin-aldosterone system activity, in the sympathetic tone and in salt-sensitivity, all in turn leading to endothelial dysfunction, arterial stiffness and increase in blood pressure...
November 2, 2017: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29089370/enjoyment-of-spicy-flavor-enhances-central-salty-taste-perception-and-reduces-salt-intake-and-blood-pressure
#19
Qiang Li, Yuanting Cui, Rongbing Jin, Hongmei Lang, Hao Yu, Fang Sun, Chengkang He, Tianyi Ma, Yingsha Li, Xunmei Zhou, Daoyan Liu, Hongbo Jia, Xiaowei Chen, Zhiming Zhu
High salt intake is a major risk factor for hypertension and is associated with cardiovascular events. Most countries exhibit a traditionally high salt intake; thus, identification of an optimal strategy for salt reduction at the population level may have a major impact on public health. In this multicenter, random-order, double-blind observational and interventional study, subjects with a high spice preference had a lower salt intake and blood pressure than subjects who disliked spicy food. The enjoyment of spicy flavor enhanced salt sensitivity and reduced salt preference...
October 31, 2017: Hypertension
https://www.readbyqxmd.com/read/29073903/characterizing-endophytic-competence-and-plant-growth-promotion-of-bacterial-endophytes-inhabiting-the-seed-endosphere-of-rice
#20
Denver I Walitang, Kiyoon Kim, Munusamy Madhaiyan, Young Kee Kim, Yeongyeong Kang, Tongmin Sa
BACKGROUND: Rice (Oryza sativa L. ssp. indica) seeds as plant microbiome present both an opportunity and a challenge to colonizing bacterial community living in close association with plants. Nevertheless, the roles and activities of bacterial endophytes remain largely unexplored and insights into plant-microbe interaction are compounded by its complexity. In this study, putative functions or physiological properties associated with bacterial endophytic nature were assessed. Also, endophytic roles in plant growth and germination that may allow them to be selectively chosen by plants were also studied...
October 26, 2017: BMC Microbiology
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