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PET-CT scleroderma

Takeaki Uehara, Mitsuhiro Takeno, Maasa Hama, Ryusuke Yoshimi, Akiko Suda, Atsushi Ihata, Atsuhisa Ueda, Ukihide Tateishi, Yoshiaki Ishigatsubo
OBJECTIVE: To examine clinical utility of (18)F-flurodeoxyglucose (FDG)-positron emission tomography (PET)/CT for assessment of interstitial lung disease (ILD) in patients with connective tissue diseases (CTDs). METHODS: A total of 69 (18)F-FDG PET/CT scans were conducted under deep inspiratory breath hold (DIBH) conditions in 45 CTD patients with ILD, including 16 dermatomyositis/polymyositis, nine systemic scleroderma and seven rheumatoid arthritis. Intensity and distribution of (18)F-FDG signals in PET/CT were determined by standardized uptake value (SUVmax) and visual score in 18 regions, respectively...
2016: Modern Rheumatology
P Sewerin, B Ostendorf
Modern imaging procedures play an import role in diagnostic and therapy-control in rheumatic diseases. Reasons are the continuous development, the evaluation and the implementation in local / international guidelines and classification criteria. According to new therapeutic goals and the aim of clinical and radiological remission the early diagnosis and sufficient therapy-control is unalterable. The ultrasound is today an inherent tool in the early diagnosis of joint- and vascular diseases and is used comprehensively in rheumatic diseases...
September 2014: Deutsche Medizinische Wochenschrift
Hyun Jeong Kim, Sang-Won Lee, Gi Jeong Kim, Jae-Hoon Lee
Eosinophilic fasciitis is a rare disorder with similar characteristics of scleroderma-like illness. We report a case of eosinophilic fasciitis in a 37-year-old woman with a 3-month history of progressive stiffness involving her forearms and lower legs. Laboratory test disclosed elevated erythrocyte sedimentation ratio and hypereosinophilia. On PET/CT images, FDG uptake was increased along the fasciae of bilateral upper and lower extremities while sparing muscles and subcutaneous fat. Biopsy was performed and histologic examination confirmed diagnosis of eosinophilic fasciitis...
September 2014: Clinical Nuclear Medicine
Camille Cohen, Arsène Mekinian, Yurdagul Uzunhan, Anne-Laure Fauchais, Robin Dhote, Gabriel Pop, Véronique Eder, Hilario Nunes, Pierre-Yves Brillet, Dominique Valeyre, Olivier Fain, Michaël Soussan
OBJECTIVE: This study aims to determine the value of FDG-PET/CT to assess disease activity in patients with Sjögren's syndrome (SS). METHODS: Thirty-two patients with SS who underwent PET/CT were retrospectively analyzed. PET/CT activity score was measured using a 6-point scale including the 6 following items (0/1: absence or presence of an item): lymphadenopathy on CT, high-resolution CT (HRCT) evidence of interstitial lung disease (ILD), parotid glands SUVmax >3, submandibular glands SUVmax >3, lymph node uptake, ILD uptake...
September 2013: Autoimmunity Reviews
Sindu Sheth, Andrew Kim, William D Bishop, Shahram Bonyadlou, Robert Henderson
We report the F-FDG PET/CT appearance of a metastatic biopsy-proven malignant fibroxanthoma of the ankle. A 41-year-old female patient with a history of scleroderma presented with a fungating mass in the left ankle. Shave biopsy of the overlying skin showed atypical fibroxanthoma (AFX). Staging FDG PET/CT demonstrated a hypermetabolic exophytic soft tissue mass in the left ankle with local extension to bone and widespread metastatic disease including pulmonary parenchyma, nodes, bone marrow, and skeletal muscle...
June 2013: Clinical Nuclear Medicine
Navneet Singh, Karan Madan, Anish Bhattacharya, Raje Nijhawan
Malignant pleural mesothelioma (MPM) is a relatively rare but aggressive pleural tumor. Systemic sclerosis (SSc) is associated with the development of lung cancer and other malignancies. We describe a 58-year-old never-smoker female, previously diagnosed with limited cutaneous SSc, who presented with chest pain on the left side, dyspnea and circumferential nodular left pleural thickening. Fluorodeoxyglucose positron-emission tomography-computed tomography showed intense uptake in the thickened left pleura, mediastinal lymph nodes and left femur...
2013: Respiration; International Review of Thoracic Diseases
Honoka Arai, Hisako Iso, Yukihiro Arai, Jiro Tadokoro, Yuko Nakamura, Tetsuya Yamagata, Kinuko Mitani
Malignant lymphoma (ML) is frequently associated with several forms of collagen diseases such as Sjören syndrome, systemic lupus erythematodes, and rheumatoid arthritis. However, the occurrence of ML in systemic sclerosis (SSc) patients has rarely been reported. Here we report an SSc patient who developed mediastinal (thymic) large B-cell lymphoma (MLBCL). A 31-year-old woman was diagnosed as having SSc in August 2007. The patient was treated with low-dose prednisolone (10 mg/day) without any effect. One year after the diagnosis, chest computed tomography-scan demonstrated thymic tumor in the anterior mediastinum...
February 2009: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Sebastian Kos, Deniz Bilecen, Daniel Baumhoer, Nicolas Guillaume, Augustinus L Jacob
A 72-year-old man was referred to our department with an incidentally diagnosed bronchogenic carcinoma of the right upper lobe. Positron emission tomography (PET) combined with computed tomography (PET-CT) revealed an unexpected hot spot in the ventral wall of the infrarenal segment of the inferior vena cava (IVC). Diagnostic biopsy of this lesion was performed under CT guidance with semiautomated 20G fine-needle aspiration (FNA) through a 19G coaxial needle. Cytology revealed few carcinoma cells, which led to the remarkable diagnosis of a distant metastasis to the IVC wall...
February 2010: Cardiovascular and Interventional Radiology
Jules Lavalaye, Jan C Grutters, Ewoudt M W van de Garde, Monique M C van Buul, Jules M M van den Bosch, Albert D Windhorst, Fred J Verzijlbergen
PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which no single diagnostic modality is able to evaluate the activity of the disease process. Cis-4-(18)F-fluoro-L: -proline ((18)F-proline) was shown in animal studies to be a reliable marker for fibrosis formation. We tested this candidate radioligand for imaging of fibrogenesis in patients with IPF. METHODS: Five patients with IPF proven by lung biopsy and computed tomography were included...
March 2009: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
N F Hopkins, T J Spinks, C G Rhodes, A S Ranicar, C W Jamieson
Oxygen-15 administered by continuous inhalation and emission computed tomography were used to study regional tissue oxygen utilisation and blood flow in the limbs of 11 patients with venous ulceration and five patients with liposclerosis due to venous insufficiency. The results showed increased blood flow and appreciably reduced fractional oxygen extraction in the diseased tissues. These findings indicated a local, functional shunting of blood through the abnormal microcirculation of the skin and subcutaneous tissues...
January 29, 1983: British Medical Journal (1981-1988)
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