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https://www.readbyqxmd.com/read/29024236/mesenchymal-stromal-cell-derived-extracellular-vesicles-provide-long-term-survival-after-total-body-irradiation-without-additional-hematopoietic-stem-cell-support
#1
Jill-Sandra Schoefinius, Bärbel Brunswig-Spickenheier, Thomas Speiseder, Sabrina Krebs, Ursula Just, Claudia Lange
The therapeutic effect of mesenchymal stromal cells (MSC) in tissue regeneration is based mainly on the secretion of bioactive molecules. Here, we report that the radioprotective effect of mouse bone marrow derived MSC (mMSC) can be attributed to extracellular vesicles (EV) released from mMSC. The transplantation of mMSC-derived EV into lethally irradiated mice resulted in long-term survival but no improvement in short-term reconstitution of the recipients. Importantly, the radiation rescue was efficient without additional hematopoietic support...
October 11, 2017: Stem Cells
https://www.readbyqxmd.com/read/29016939/molecular-autopsy-of-sudden-unexplained-deaths-reveals-genetic-predispositions-for-cardiac-diseases-among-young-forensic-cases
#2
Nicole Hellenthal, Anna Gaertner-Rommel, Bärbel Klauke, Lech Paluszkiewicz, Markus Stuhr, Thoralf Kerner, Martin Farr, Klaus Püschel, Hendrik Milting
Aims: Coronary artery disease accounts for the majority of sudden cardiac deaths (SCD) in the older population whereas cardiomyopathies and arrhythmogenic abnormalities predominate in younger SCD victims (<35 years) with a significant genetic component. The elucidation of the pathogenetic cause of death might be relevant for the prevention of further deaths within affected families. Aim of this study was to determine the portion of underlying genetic heart diseases among unexplained putative SCD cases from a large German forensic department...
October 17, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29016477/shod-versus-barefoot-effects-on-force-and-power-development-during-a-conventional-deadlift
#3
Mark E Hammer, Rudi A Meir, John W Whitting, Zachary J Crowley-McHattan
The kinetics of a conventional deadlift in shod (S) versus unshod (US) footwear conditions in 10 male participants (mean ± SD, age = 27.0 ± 5.8 years; weight = 78.7 ± 11.5 kg; height = 175.8 ± 8.2 cm; 1RM deadlift = 155.8 ± 25.8 kg) was assessed in two testing sessions. A counterbalanced, crossover experimental design was used with different loads (60% and 80% 1RM). Four sets of four repetitions were prescribed per session with two sets per shoe and with each shoe condition involving one set per load. Peak vertical force (PF), rate of force development (RFD), time to peak force (TPF), anterior-posterior (COP-AP) and medio-lateral (COP-ML) center of pressure excursion, and barbell peak power (PP) data were recorded during all repetitions...
October 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28981111/mechanisms-of-bystander-effects-in-retinal-pigment-epithelium-cell-networks
#4
Masaaki Ishii, Bärbel Rohrer
No abstract text is available yet for this article.
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28963753/granulocytic-myeloid-derived-suppressor-cells-gr-mdsc-accumulate-in-cord-blood-of-preterm-infants-and-remain-elevated-during-the-neonatal-period
#5
Julian Schwarz, Vera Scheckenbach, Hellen Kugel, Bärbel Spring, Julia Pagel, Christoph Härtel, Jan Pauluschke-Fröhlich, Andreas Peter, Christian F Poets, Christian Gille, Natascha Köstlin
Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-foetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until now, nothing is known about expression of MDSC in preterm infants...
September 30, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28948078/muscle-training-induced-bilateral-brachial-plexopathy-in-an-adolescent-with-sporadic-hereditary-neuropathy-with-liability-to-pressure-palsies
#6
Minori Kodaira, Satoshi Kodama, Yui Kamijo, Tomoki Kaneko, Yoshiki Sekijima
There have been few studies regarding physical training-induced peripheral nerve dysfunction in patients with hereditary neuropathy with liability to pressure palsies (HNPP), with the exception of soldiers that trained intensively. Here, we report a 15-year-old boy without family history of HNPP who developed bilateral painless brachial plexopathy following short-term barbell and plank training during a school baseball club activity. Muscle training-induced painless brachial plexopathy could be an initial symptom and may be underdiagnosed in adolescents with sporadic HNPP...
September 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28912650/the-effects-combining-cryocompression-therapy-following-an-acute-bout-of-resistance-exercise-on-performance-and-recovery
#7
William H DuPont, Brek J Meuris, Vincent H Hardesty, Emily C Barnhart, Landon H Tompkins, Morricia J P Golden, Clayton J Usher, Paul A Spence, Lydia K Caldwell, Emily M Post, Matthew K Beeler, William J Kraemer
Compression and cold therapy used separately have shown to reduce negative effects of tissue damage. The combining compression and cold therapy (cryocompression) as a single recovery modality has yet to be fully examined. To examine the effects of cryocompression on recovery following a bout of heavy resistance exercise, recreationally resistance trained men (n =16) were recruited, matched, and randomly assigned to either a cryocompression group (CRC) or control group (CON). Testing was performed before and then immediately after exercise, 60 minutes, 24 hours, and 48 hours after a heavy resistance exercise workout (barbell back squats for 4 sets of 6 reps at 80% 1RM, 90 sec rest between sets, stiff legged deadlifts for 4 sets of 8 reps at 1...
September 2017: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/28900561/effects-of-a-band-loop-on-lower-extremity-muscle-activity-and-kinematics-during-the-barbell-squat
#8
Ryan C A Foley, Brittany D Bulbrook, Duane C Button, Michael W R Holmes
BACKGROUND: Medial knee collapse can signal an underlying movement issue that, if uncorrected, can lead to a variety of knee injuries. Placing a band around the distal thigh may act as a proprioceptive aid to minimize medial collapse of the knee during squats; however, little is known about EMG and biomechanics in trained and untrained individuals during the squat with an elastic band added. HYPOTHESIS/PURPOSE: To investigate the effects of the TheraBand® Band Loop on kinematics and muscle activity of the lower extremity during a standard barbell back squat at different intensities in both trained and untrained individuals...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28895467/kinetic-and-kinematic-patterns-during-high-intensity-clean-movement-searching-for-optimal-load
#9
Achraf Ammar, Bryan L Riemann, Liwa Masmoudi, Marcel Blaumann, Osama Abdelkarim, Anita Hökelmann
The aim of the present study was to investigate loading effects on kinematic and kinetic variables among elite-weightlifters in order to identify an optimal training load to maximize power production for clean-movement. Nine elite-weightlifter (age: 24 ± 4years, body-mass: 77 ± 6.5kg, height: 176 ± 6.1cm and 1RM clean: 170 ± 5kg) performed 2 separate repetitions of the clean using 85, 90, 95% and 100%, in a randomized order, while standing on a force platform and being recorded using 3D-capture-system. Differences in kinematics (barbell displacement, velocity and acceleration) and kinetics (power, vertical ground reaction force (vGRF), rate of force development (RFD), and work) across the loads were statistically assessed...
September 12, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28894425/analysis-of-wearable-and-smartphone-based-technologies-for-the-measurement-of-barbell-velocity-in-different-resistance-training-exercises
#10
Carlos Balsalobre-Fernández, David Marchante, Eneko Baz-Valle, Iván Alonso-Molero, Sergio L Jiménez, Mario Muñóz-López
The purpose of this study was to analyze the validity, reliability, and accuracy of new wearable and smartphone-based technology for the measurement of barbell velocity in resistance training exercises. To do this, 10 highly trained powerlifters (age = 26.1 ± 3.9 years) performed 11 repetitions with loads ranging 50-100% of the 1-Repetition maximum in the bench-press, full-squat, and hip-thrust exercises while barbell velocity was simultaneously measured using a linear transducer (LT), two Beast wearable devices (one placed on the subjects' wrist -BW-, and the other one directly attached to the barbell -BB-) and the iOS PowerLift app...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28880485/pediatric-diabetes-training-for-healthcare-professionals-in-europe-time-for-change
#11
Nicky Helen Kime, Sheridan Waldron, Elizabeth Webster, Karin Lange, Katarzyna Zinken, Thomas Danne, Bärbel Aschemeier, Zdenek Sumnik, Ondrej Cinek, João Filipe Raposo, Andriani Vazeou, Natasa Bratina, Fiona Campbell
BACKGROUND: Training for healthcare professionals (HCPs) in Europe who care for children and young people (CYP) with type 1 diabetes and their families is variable depending on the country. Building on the work of SWEET (Better control in Pediatric and Adolescent diabeteS: Working to crEate CEnTers of Reference) and using the German Certified Diabetes Educators (CDEs) curriculum, a European collaboration of pediatric diabetes experts aimed to (1) establish current core elements that should be included in a pediatric diabetes education training course and (2) create a template for a European CDE's training curriculum...
September 7, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28877270/management-of-pancreatic-pseudocysts-a-retrospective-analysis
#12
Sebastian Rasch, Bärbel Nötzel, Veit Phillip, Tobias Lahmer, Roland M Schmid, Hana Algül
BACKGROUND: Pancreatic pseudocysts arise mostly in patients with alcohol induced chronic pancreatitis causing various symptoms and complications. However, data on the optimal management are rare. To address this problem, we analysed patients with pancreatic pseudocysts treated at our clinic retrospectively. METHODS: We searched our clinical database for the diagnosis pancreatitis from 2004 till 2014, selected patients with pseudocysts larger than 10 mm and entered all relevant information in a database for statistical analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28873044/loaded-hip-thrust-based-pap-protocol-effects-on-acceleration-and-sprint-performance-of-handball-players
#13
Antonio Dello Iacono, Johnny Padulo, Laurent D Seitz
This study aimed to investigate the acute effects of two barbell hip thrust-based (BHT) post-activation potentiation (PAP) protocols on subsequent sprint performance. Using a crossover design, eighteen handball athletes performed maximal 15-m sprints before and 15s, 4min and 8min after two experimental protocols consisting of BHT loaded with either 50% or 85% 1RM (50PAP and 85PAP, respectively), in order to profile the transient PAP effects. The resulting sprint performances were significantly impaired at 15s only after the 85PAP protocol, which induced likely and very likely greater decreases compared to the 50PAP...
September 5, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28842371/molecular-cloning-and-functional-characterization-of-interferon-regulatory-factor-7-of-the-barbel-chub-squaliobarbus-curriculus
#14
Xin Zhao, Ronghua Wang, Yaoguo Li, Tiaoyi Xiao
The interferon regulatory factor 7 (IRF7) is a critical regulator of type-I interferon-dependent immune reaction that defense against virus. To investigate the antiviral function of IRF7 of barbel chub Squaliobarbus curriculus (ScIRF7), the cDNA of ScIRF7 was cloned and characterized. The full length cDNA of ScIRF7 was 1870 bp, consisted of 41 bp 5'-UTR, 560 bp 3'-UTR and a 1269 bp open reading frame (ORF). The ORF encoded 423 amino acids with a molecular weight of 49.426 KDa and a theoretical isoelectric point of 5...
August 24, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28822013/biomonitoring-of-chemicals-in-biota-of-two-wetland-protected-areas-exposed-to-different-levels-of-environmental-impact-results-of-the-previeni-project
#15
Cristiana Guerranti, Guido Perra, Eva Alessi, Davide Baroni, Dante Caserta, Donatella Caserta, Augusto De Sanctis, Emiliano Leonida Fanello, Cinzia La Rocca, Michela Mariottini, Monia Renzi, Sabrina Tait, Carlo Zaghi, Alberto Mantovani, Silvano Ettore Focardi
The PREVIENI project (funded by the Ministry of Environment) investigated the exposure to endocrine disrupters in samples of human population and environmental biota in Italy. The environmental biomonitoring considered two Italian WWF Oasis, with the aim to compare the presence and effects of endocrine disruptors in organisms from two protected natural areas, respectively, upstream and downstream a chemical emission site. Chemical analysis of pollutants' tissue levels was made on tissues from earthworm, barbell, trout, and coot, selected as bioindicator organisms...
August 18, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28810360/habit-strength-as-a-moderator-of-the-association-between-symptoms-of-poor-mental-health-and-unintentional-non-adherence-to-oral-hypoglycemic-medication-in-adults-with-type-2-diabetes
#16
Rachel J Burns, Sonya S Deschênes, Bärbel Knäuper, Norbert Schmitz
This study tested if habit strength for taking oral hypoglycemic medication moderated the association between poor mental health symptoms (i.e. depressive symptoms, diabetes distress) and unintentional non-adherence in 790 adults with type 2 diabetes. Data were cross-sectional. A habit strength × depressive symptom interaction was observed. Depressive symptoms were negatively associated with adherence if habit was weak or of average strength; no association was observed if habit was strong. A similar interaction emerged when diabetes distress was examined...
October 1, 2016: Journal of Health Psychology
https://www.readbyqxmd.com/read/28810065/olodaterol-shows-anti-fibrotic-efficacy-in-in-vitro-and-in-vivo-models-of-pulmonary-fibrosis
#17
Franziska Elena Herrmann, Lutz Wollin, Johannes Wirth, Florian Gantner, Bärbel Lämmle, Eva Wex
BACKGROUND AND PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by excessive fibroblast activation ultimately leading to scarring of the lungs. Although, the activation of β2 -adrenergic receptors (β2 -AR) has been shown to inhibit pro-fibrotic events primarily in cell lines, the role of β2 -AR agonism has not yet been fully characterized. The aim of our study was to explore the anti-fibrotic activity of the long-acting β2 -AR-agonist olodaterol in primary human lung fibroblasts, and in murine models of pulmonary fibrosis...
August 15, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28806939/effect-of-electromagnetic-fields-on-human-osteoarthritic-and-non-osteoarthritic-chondrocytes
#18
Julia Isabelle Redeker, Bärbel Schmitt, Nele Pascale Grigull, Christian Braun, Andreas Büttner, Volkmar Jansson, Susanne Mayer-Wagner
BACKGROUND: Studies of the effects of electromagnetic fields (EMFs) on cartilaginous cells show a broad range of outcomes. However EMFs are not yet clinically applied as standard treatment of osteoarthritis, as EMF effects are showing varying outcomes in the literature. The aim of this study was to examine effects of EMFs (5 mT or 8 mT) on osteoarthritic (OA) and non-OA chondrocytes in order to investigate whether EMF effects are related to chondrocyte and EMF quality. METHODS: Pellets of human OA and non-OA chondrocytes were exposed to a sinusoidal 15 Hz EMF produced by a solenoid...
August 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28796130/the-effects-of-superset-configuration-on-kinetic-kinematic-and-perceived-exertion-in-the-barbell-bench-press
#19
Jonathon Js Weakley, Kevin Till, Dale B Read, Padraic J Phibbs, Gregory Roe, Joshua Darrall-Jones, Ben L Jones
Training that is efficient and effective is of great importance to an athlete. One method of improving efficiency is by incorporating supersets into resistance training routines. However, the structuring of supersets is still unexplored. Therefore, the purpose of this study was to assess the effects of agonist-antagonist (A-A), alternate peripheral (A-P), and similar biomechanical (SB) superset configurations on rate of perceived exertion (RPE), kinetic and kinematic changes during the bench press. 10 subjects performed resistance training protocols in a randomized-crossover design, with magnitude-based inferences assessing changes/differences within and between protocols...
August 4, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28792857/redistributing-load-using-wearable-resistance-during-power-clean-training-improves-athletic-performance
#20
RANDOMIZED CONTROLLED TRIAL
Caleb R Marriner, John B Cronin, Paul Macadam, Adam Storey
A popular method to improve athletic performance and lower body power is to train with wearable resistance (WR), for example, weighted vests. However, it is currently unknown what training effect this loading method has on full-body explosive movements such as the power clean. The purpose of this study was to determine what effects WR equivalent to 12% body mass (BM) had on the power clean and countermovement jump (CMJ) performance. Sixteen male subjects (age: 23.2 ± 2.7 years; BM: 90.5 ± 10.3 kg) were randomly assigned to five weeks of traditional (TR) power clean training or training with 12% BM redistributed from the bar to the body using WR...
October 2017: European Journal of Sport Science
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