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https://www.readbyqxmd.com/read/29663071/cyclosporine-a-responsive-congenital-nephrotic-syndrome-with-single-heterozygous-variants-in-nphs1-nphs2-and-plce1
#1
Anna Eichinger, Sabine Ponsel, Carsten Bergmann, Roman Günthner, Julia Hoefele, Kerstin Amann, Bärbel Lange-Sperandio
BACKGROUND: Congenital nephrotic syndrome (CNS) is primarily a monogenetic disease, with the majority of cases due to changes in five different genes: the nephrin (NPHS1), podocin (NPHS2), Wilms tumor 1 (WT1), laminin ß2 (LAMB2), and phospholipase C epsilon 1 (PLCE1, NPHS3) gene. Usually CNS is not responsive to immunosuppressive therapy, but treatment with ACE inhibitors, AT1 receptor blockade and/or indomethacin can reduce proteinuria. If the disease progresses to end-stage renal disease, kidney transplantation is the therapy of choice...
April 16, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29655705/spatially-correlated-gene-expression-in-bacterial-groups-the-role-of-lineage-history-spatial-gradients-and-cell-cell-interactions
#2
Simon van Vliet, Alma Dal Co, Annina R Winkler, Stefanie Spriewald, Bärbel Stecher, Martin Ackermann
Gene expression levels in clonal bacterial groups have been found to be spatially correlated. These correlations can partly be explained by the shared lineage history of nearby cells, although they could also arise from local cell-cell interactions. Here, we present a quantitative framework that allows us to disentangle the contributions of lineage history, long-range spatial gradients, and local cell-cell interactions to spatial correlations in gene expression. We study pathways involved in toxin production, SOS stress response, and metabolism in Escherichia coli microcolonies and find for all pathways that shared lineage history is the main cause of spatial correlations in gene expression levels...
April 5, 2018: Cell Systems
https://www.readbyqxmd.com/read/29623782/local-introgression-of-mitochondrial-dna-in-eight-barbel-loaches-of-the-genus-lefua-balitoridae-cypriniformes
#3
Jun-Ichi Miyazaki, Toshio Tamura, Seiya Hida, Takehiko Sakai
The evolutionary history of eight-barbel loaches of the genus Lefua was investigated to resolve the faunal formation and evolutionary history of Japanese and East Asian freshwater fishes. In the present study, we found that seven Lefua specimens obtained from western Japan could not be assigned genetically to any population recognized so far, although they were morphologically and ecologically indistinguishable from Lefua sp 1. We tentatively designated the specimens as the Nihonkai population. Sequencing of the mitochondrial D-loop region showed that five specimens of the Nihonkai population were allied with the Kinki and Tokai populations of L...
April 2018: Zoological Science
https://www.readbyqxmd.com/read/29595081/hip-thrust-based-pap-effects-on-sprint-performance-of-soccer-players-heavy-loaded-versus-optimum-power-development-protocols
#4
Antonio Dello Iacono, Laurent B Seitz
This study aimed to investigate the acute effects of two barbell hip thrust-based post-activation potentiation (PAP) protocols on subsequent sprint performance. Using a crossover design, eighteen soccer athletes performed 5 m, 10 m, and 20 m sprints before and 15 s, 4 min, and 8 min after two PAP protocols. The PAP conditioning activities consisted of hip thrust exercises loaded with either 85% 1RM or a load for optimum power development. The resulting 5 m and 10 m sprint performances were impaired at 15 s following both protocols...
March 29, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29576927/encapsulated-cell-technology-based-delivery-of-a-complement-inhibitor-reduces-choroidal-neovascularization-in-a-mouse-model
#5
Balasubramaniam Annamalai, Nathaniel Parsons, Marwa Belhaj, Carlene Brandon, Jay Potts, Bärbel Rohrer
Purpose: Age-related macular degeneration (AMD) is a slowly progressing disease, and risk appears to be tied to an overactive complement system. We have previously demonstrated that mouse choroidal neovascularization (CNV) and smoke-induced ocular pathology can be reduced with an alternative pathway (AP) inhibitor fusion protein consisting of a complement receptor-2 fragment linked to the inhibitory domain of factor H (CR2-fH) when delivered systemically. Here we developed an experimental approach with genetically engineered encapsulated ARPE-19 cells to produce CR2-fH intravitreally...
March 2018: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29570575/evaluation-of-the-most-reliable-procedure-of-determining-jump-height-during-the-loaded-countermovement-jump-exercise-take-off-velocity-vs-flight-time
#6
Alejandro Pérez-Castilla, Amador García-Ramos
This study aimed to compare the reliability of jump height between the two standard procedures of analysing force-time data (take-off velocity [TOV] and flight time [FT]) during the loaded countermovement (CMJ) exercise performed with a free-weight barbell and in a Smith machine. The jump height of 17 men (age: 22.2 ± 2.2 years, body mass: 75.2 ± 7.1 kg, height: 177.0 ± 6.0 cm) was tested in four sessions (twice for each CMJ type) against external loads of 17, 30, 45, 60, and 75 kg. Jump height reliability was comparable between the TOV (coefficient of variation [CV]: 6...
March 22, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29561369/nurse-s-guide-to-primary-amebic-meningoencephalitis
#7
Kathleen Peterson, Paula Barbel, Elizabeth Heavey
No abstract text is available yet for this article.
April 2018: Nursing
https://www.readbyqxmd.com/read/29546521/cmr-substances-in-consumer-products-from-food-contact-materials-to-toys
#8
EDITORIAL
Ariane Lenzner, Bärbel Vieth, Andreas Luch
No abstract text is available yet for this article.
March 16, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29528960/knee-kinetics-during-squats-of-varying-loads-and-depths-in-recreationally-trained-females
#9
Victoria Flores, James Becker, Eric Burkhardt, Joshua Cotter
The back squat exercise is typically practiced with varying squat depths and barbell loads. However, depth has been inconsistently defined, resulting in unclear safety precautions when squatting with loads. Additionally, females exhibit anatomical and kinematic differences to males which may predispose them to knee joint injuries. The purpose of this study was to characterize peak knee extensor moments (pKEMs) at three commonly practiced squat depths of above parallel, parallel, and full depth, and with three loads of 0% (unloaded), 50%, and 85% depth-specific one repetition maximum (1RM) in recreationally active females...
March 6, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29518677/ultrasound-based-prediction-of-pathologic-response-to-neoadjuvant-chemotherapy-in-breast-cancer-patients
#10
Annina Baumgartner, Christoph Tausch, Stefanie Hosch, Bärbel Papassotiropoulos, Zsuzsanna Varga, Christoph Rageth, Astrid Baege
BACKGROUND: Accuracy in predicting pathologic response to neoadjuvant chemotherapy (NACT) in breast cancer is essential for the determination of therapeutic efficacy and surgical planning. This study aimed to assess the precision of ultrasound (US) for predicting pathologic complete response (pCR = ypT0) after NACT. METHODS: This retrospective mono-center study included 124 invasive breast cancer patients treated with NACT. Patients received US before and after NACT with documentation of clinical partial response (cPR) and clinical complete response (cCR)...
March 5, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29517412/distribution-of-lower-extremity-work-during-clean-variations-performed-with-different-effort
#11
Torstein E Dæhlin, Tron Krosshaug, Loren Z F Chiu
The purpose of this research was to investigate how lower extremity work was distributed during the pull of cleans performed lifting the barbell to the minimum height required to receive it in a full squat (minimal height clean); or with maximum effort to elevate the barbell as high as possible and receiving it in either a full (maximal effort clean) or partial (power clean) squat. Eight weightlifters screened for proficient technique performed these clean variations at 80% of one repetition maximum. Work performed on the barbell and by the lower extremity net joint moments (NJM) was computed from marker trajectories and ground reaction forces...
March 8, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29503093/contractile-work-contributes-to-maturation-of-energy-metabolism-in-hipsc-derived-cardiomyocytes
#12
Bärbel M Ulmer, Andrea Stoehr, Mirja L Schulze, Sajni Patel, Marjan Gucek, Ingra Mannhardt, Sandra Funcke, Elizabeth Murphy, Thomas Eschenhagen, Arne Hansen
Energy metabolism is a key aspect of cardiomyocyte biology. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are a promising tool for biomedical application, but they are immature and have not undergone metabolic maturation related to early postnatal development. To assess whether cultivation of hiPSC-CMs in 3D engineered heart tissue format leads to maturation of energy metabolism, we analyzed the mitochondrial and metabolic state of 3D hiPSC-CMs and compared it with 2D culture. 3D hiPSC-CMs showed increased mitochondrial mass, DNA content, and protein abundance (proteome)...
March 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29489730/a-biomechanical-analysis-of-the-effects-of-bouncing-the-barbell-in-the-conventional-deadlift
#13
Kellen Krajewski, Robert LeFavi, Bryan Riemann
The purpose of this study is to analyze biomechanical differences between the bounce and pause styles of deadlifting. Twenty physically active males performed deadlifts at their 75% one repetition maximum testing utilizing both pause and bounce techniques in a within-subjects randomized study design. The average peak height the barbell attained from the three bounce style repetitions was used to compute a compatible phase for analysis of the pause style repetitions. Net joint moment impulse (NJMI), work, average vertical ground reaction force (vGRF), vGRF impulse and phase time were computed for two phases, lift off to peak barbell height and the entire ascent...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29489722/biomechanical-anthropometric-and-psychological-determinants-of-barbell-back-squat-strength
#14
Andrew D Vigotsky, Megan A Bryanton, Greg Nuckols, Chris Beardsley, Bret Contreras, Jessica Evans, Brad J Schoenfeld
Previous investigations of strength have only focused on biomechanical or psychological determinants, while ignoring the potential interplay and relative contributions of these variables. The purpose of this study was to investigate the relative contributions of biomechanical, anthropometric, and psychological variables to the prediction of maximum parallel barbell back squat strength. Twenty-one college-aged participants (male = 14; female = 7; age = 23 ± 3 years) reported to the laboratory for two visits...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29489716/the-effect-of-barbell-load-on-vertical-jump-landing-force-time-characteristics
#15
Jason P Lake, Peter D Mundy, Paul Comfort, John J McMahon, Timothy J Suchomel, Patrick Carden
The aim of this study was to quantify the effect that barbell load has on the jump height and force-time characteristics of the countermovement jump (CMJ). Fifteen strengthtrained men (mean ± SD: age 23 ± 2 years, mass 84.9 ± 8.1 kg, height 1.80 ± 0.05 m) performed three CMJ with no additional load, and with barbell loads of 25%, 50%, 75%, and 100% of body mass on two force plates recording at 1000 Hz. Propulsion and landing force-time characteristics were obtained from force-time data and compared using analysis of variance and effect sizes...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29489715/force-velocity-relationship-in-three-different-variations-of-prone-row-exercises
#16
Irineu Loturco, Timothy Suchomel, Ronaldo Kobal, Ademir F S Arruda, Aristide Guerriero, Lucas A Pereira, Chi Nan Pai
This study examined the force-velocity relationship and tested the possibility of determining the relative loading intensity (% 1RM) in three different variations of prone row exercises. Thirty male top-level athletes from two different sports (National Team rugby union players and professional mixed martial arts fighters) were submitted to maximum dynamic strength assessments in the free prone bench pull, bent over barbell row, and bent over Smith-machine row, following standard procedures encompassing lifts performed from 40 to 100% of 1RM...
February 27, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29475094/effects-of-levetiracetam-and-sulthiame-on-eeg-in-benign-epilepsy-with-centrotemporal-spikes-a-randomized-controlled-trial
#17
Moritz Tacke, Ingo Borggraefe, Lucia Gerstl, Florian Heinen, Katharina Vill, Michaela Bonfert, Thomas Bast, Bernd Axel Neubauer, Friedrich Baumeister, Martina Baethmann, Karl Bentele, Christian Blank, Harald M Blank, Harald Bode, Friedrich Bosch, Ulrich Brandl, Knut Brockmann, Peter Dahlem, Jan-Peter Ernst, Evemarie Feldmann, Andreas Fiedler, Michael Gerigk, Soeren Heß, Christiane Hikel, Hans-Georg Hoffmann, Matthias Kieslich, Joerg Klepper, Gerhard Kluger, Hartmut Koch, Walter Koch, Rudolf Korinthenberg, Ilona Krois, Hermann Kühne, Gerhard Kurlemann, Michaela Mandl, Ulrike Mause, Peter Navratil, Joachim Opp, Johann Penzien, Viola Prietsch, Axel Quattländer, Dietz Rating, Ulrike Schara, Mohammed G Shamdeen, Andreas Sprinz, Hildegard Wendker-Magrabi, Ulrich Stephani, Hiltrud Muhle, Hans-Michael Straßburg, Bärbel Töpke, Regina Trollmann, Elisabeth Tuschen-Hofstätter, Stephan Waltz, Gabriele Weber, Frank U Wien, Markus Wolff, Tilman Polster, Hedwig Freitag, Ötzcam Sönmez, Klaus Reinhardt, Marion Traus, Zeecam Hoovey
PURPOSE: BECTS (benign childhood epilepsy with centrotemporal spikes) is associated with characteristic EEG findings. This study examines the influence of anti-convulsive treatment on the EEG. METHODS: In a randomized controlled trial including 43 children with BECTS, EEGs were performed prior to treatment with either Sulthiame or Levetiracetam as well as three times under treatment. Using the spike-wave-index, the degree of EEG pathology was quantified. The EEG before and after initiation of treatment was analyzed...
February 3, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29461422/eight-weeks-of-strength-and-power-training-improves-club-head-speed-in-collegiate-golfers
#18
Dustin J Oranchuk, Jason M Mannerberg, Tracey L Robinson, Megan C Nelson
Club head speed (CHS) is a major determinant of drive distance, a key component of golf performance. The purpose of this study was to determine the indirect effects of an eight-week strength and power program on CHS. Twelve (6 male, 6 female) NCAA Division II golfers (20.3±1.5 years) randomly assigned to an intervention or control group, underwent either a periodized strength and power program consisting of high-load barbell movements or a bodyweight and rotational movement focused resistance training program...
February 14, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29458671/roseisolibacter-agri-gen-nov-sp-nov-a-novel-slow-growing-member-of-the-under-represented-phylum-gemmatimonadetes
#19
Javier Pascual, Bärbel U Foesel, Alicia Geppert, Katharina J Huber, Christian Boedeker, Manja Luckner, Gerhard Wanner, Jörg Overmann
A novel slow-growing bacterium, designated strain AW1220T , was isolated from agricultural floodplain soil sampled at Mashare (Kavango region, Namibia) by using a high-throughput cultivation approach. Strain AW1220T was characterized as a Gram-negative, non-motile, rod-shaped bacterium. Occasionally, some cells attained an unusual length of up to 35 µm. The strain showed positive responses for catalase and cytochrome-c oxidase and divided by binary fission and/or budding. The strain had an aerobic chemoorganoheterotrophic metabolism and was also able to grow under micro-oxic conditions...
February 14, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29436510/hidden-markov-models-for-monitoring-circadian-rhythmicity-in-telemetric-activity-data
#20
Qi Huang, Dwayne Cohen, Sandra Komarzynski, Xiao-Mei Li, Pasquale Innominato, Francis Lévi, Bärbel Finkenstädt
Wearable computing devices allow collection of densely sampled real-time information on movement enabling researchers and medical experts to obtain objective and non-obtrusive records of actual activity of a subject in the real world over many days. Our interest here is motivated by the use of activity data for evaluating and monitoring the circadian rhythmicity of subjects for research in chronobiology and chronotherapeutic healthcare. In order to translate the information from such high-volume data arising we propose the use of a Markov modelling approach which (i) naturally captures the notable square wave form observed in activity data along with heterogeneous ultradian variances over the circadian cycle of human activity, (ii) thresholds activity into different states in a probabilistic way while respecting time dependence and (iii) gives rise to circadian rhythm parameter estimates, based on probabilities of transitions between rest and activity, that are interpretable and of interest to circadian research...
February 2018: Journal of the Royal Society, Interface
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