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https://www.readbyqxmd.com/read/28333572/new-insights-on-complement-inhibitor-cd59-in-mouse-laser-induced-choroidal-neovascularization-mislocalization-after-injury-and-targeted-delivery-for-protein-replacement
#1
Gloriane Schnabolk, Mee Keong Beon, Stephen Tomlinson, Bärbel Rohrer
PURPOSE: The membrane attack complex (MAC) in choriocapillaris (CC) and retinal pigment epithelium (RPE) increase with age and disease (age-related macular degeneration). MAC assembly can be inhibited by CD59, a membrane-bound regulator. Here we further investigated the role of CD59 in murine choroidal neovascularization (CNV), a model involving both CC and RPE, and tested whether CR2-CD59, a soluble targeted form of CD59, provides protection. METHODS: Laser-induced CNV was generated in wild type and CD59a-deficient mice (CD59(-/-))...
March 23, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28331412/a-review-of-the-pseudobarbus-afer-peters-1864-species-complex-teleostei-cyprinidae-in-the-eastern-cape-fold-ecoregion-of-south-africa
#2
Albert Chakona, Paul H Skelton
The Eastern Cape redfin, Pseudobarbus afer, has long been considered to be a single widespread and variable species occurring in multiple isolated river systems in the Cape Fold Ecoregion (CFE) at the southern tip of Africa. Mitochondrial cytochrome b and control region sequence data of individuals from populations currently assigned to Pseudobarbus afer across the species' distribution range revealed existence of four deeply divergent taxonomic units: (i) the Mandela lineage confined to the Sundays, Swartkops and Baakens river systems, (ii) the Krom lineage endemic to the Krom River system, (iii) the St Francis lineage occurring in the Gamtoos and adjacent river systems, and (iv) the Forest lineage occurring in several coastal river systems from the Tsitsikamma to the Klein Brak River system...
2017: ZooKeys
https://www.readbyqxmd.com/read/28319762/growth-of-algal-biomass-in-laboratory-and-in-large-scale-algal-photobioreactors-in-the-temperate-climate-of-western-germany
#3
Christina Schreiber, Dominik Behrendt, Gregor Huber, Christian Pfaff, Janka Widzgowski, Bärbel Ackermann, Andreas Müller, Vilém Zachleder, Šárka Moudříková, Peter Mojzeš, Ulrich Schurr, Johan Grobbelaar, Ladislav Nedbal
Growth of Chlorella vulgaris was characterized as a function of irradiance in a laboratory turbidostat (1L) and compared to batch growth in sunlit modules (5-25L) of the commercial NOVAgreen photobioreactor. The effects of variable sunlight and culture density were deconvoluted by a mathematical model. The analysis showed that algal growth was light-limited due to shading by external construction elements and due to light attenuation within the algal bags. The model was also used to predict maximum biomass productivity...
March 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28315055/determination-of-heavy-metals-in-muscle-tissue-of-six-fish-species-with-different-feeding-habits-from-the-danube-river-belgrade-public-health-and-environmental-risk-assessment
#4
Dragoljub A Jovanović, Radmila V Marković, Vlado B Teodorović, Dragan S Šefer, Milena P Krstić, Stamen B Radulović, Jelena S Ivanović Ćirić, Jelena M Janjić, Milan Ž Baltić
The aim of this study was to investigate the presence of heavy metals/metalloids (Pb, Cd, Hg, Cu, Fe, Zn, As) in the muscle tissue of fish from the Danube River (two locations: Zemun and Grocka). For the purpose of heavy metal determination in fish muscle, 120 samples of six different fish species, Prussian carp, barbel, bream, carp, pike perch, and catfish were collected. For determining heavy metals, we used microwave oven digestion and atomic absorption spectrometer methods. The highest average content of Pb (0...
March 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28303891/il-21-restricts-t-follicular-regulatory-t-cell-proliferation-through-bcl-6-mediated-inhibition-of-responsiveness-to-il-2
#5
Christoph Jandl, Sue M Liu, Pablo F Cañete, Joanna Warren, William E Hughes, Alexis Vogelzang, Kylie Webster, Maria E Craig, Gulbu Uzel, Alexander Dent, Polina Stepensky, Bärbel Keller, Klaus Warnatz, Jonathan Sprent, Cecile King
T follicular regulatory (Tfr) cells control the magnitude and specificity of the germinal centre reaction, but how regulation is contained to ensure generation of high-affinity antibody is unknown. Here we show that this balance is maintained by the reciprocal influence of interleukin (IL)-2 and IL-21. The number of IL-2-dependent FoxP3(+) regulatory T cells is increased in the peripheral blood of human patients with loss-of-function mutations in the IL-21 receptor (IL-21R). In mice, IL-21:IL-21R interactions influence the phenotype of T follicular cells, reducing the expression of CXCR4 and inhibiting the expansion of Tfr cells after T-cell-dependent immunization...
March 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28303575/isoform-localization-of-dectin-1-regulates-the-signaling-quality-of-anti-fungal-immunity
#6
Mike Fischer, Jörg P Müller, Bärbel Spies-Weisshart, Christine Gräfe, Oliver Kurzai, Kerstin Hünniger, Andreas Hochhaus, Sebastian Scholl, Ulf Schnetzke
Dectin-1 is recognized as a major receptor for fungal ß-glucans and contributes to anti-fungal immunity. Human monocyte populations express Dectin-1 isoforms A and B, which differ by the presence of a stalk region and its N-linked glycosylation site. Here, we analyzed the expression of both isoforms in human monocyte-derived cells. The cellular localization on cell lines stably expressing either Dectin-1 isoform A or B was studied by flow cytometry and confocal laser scanning microscopy. Intracellular protein signaling and cytokine production was analyzed by immunoblotting and cytometric bead arrays, respectively...
March 16, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28303565/morphometry-and-microanatomy-of-the-barbels-of-the-common-sawshark-pristiophorus-cirratus-pristiophoridae-implications-for-pristiophorid-behaviour
#7
R J Nevatte, J E Williamson, N G F Vella, V Raoult, B E Wueringer
The internal anatomy of the barbels of the common sawshark Pristiophorus cirratus was examined with light microscopy to clarify their sensory role. No sensory structures such as taste buds (chemoreception), ampullae of Lorenzini (electroreception) or free neuromasts (lateral line mechanoreception) could be located in the barbels. The presence of bundles of nerve fibres, however, indicates a tactile function for the barbels. Conveyance of information regarding potentially damaging stimuli (nociception) and temperature (thermoception) cannot be excluded at this stage...
March 17, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28301442/effect-of-ankle-mobility-and-segment-ratios-on-trunk-lean-in-the-barbell-back-squat
#8
Emil Isager Fuglsang, Anders Stampe Telling, Henrik Sørensen
The barbell back squat is a popular exercise used for both performance enhancing and rehabilitation purposes. However, injuries are common and people with a history of lower back pain are especially vulnerable. Past studies have shown that higher trunk angles (less forward lean) generate less stress on the lower back; thus, it seems appropriate to investigate the factors presumed to influence the trunk angle. Therefore, the aim in this study was to investigate how ankle mobility and the segment ratios between the thoracic spine, thighs and shanks influence the trunk angle in the back squat...
March 13, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28299217/management-of-retained-genital-piercings-a-case-report-and-review
#9
Laura J Moulton, Amelia M Jernigan
The prevalence of genital piercing among women is increasing. As the popularity increases, the number of complications from infection, injury, and retained jewelry is likely to rise. Techniques to remove embedded jewelry are not well described in the literature. The purpose of this report was to describe a case of a patient with a retained clitoral glans piercing, discuss a simple technique for outpatient removal, and review current evidence regarding associated risks of clitoral piercings. A 24-year-old female presented to the emergency department with an embedded clitoral glans piercing...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28290757/hip-musculoskeletal-conditions-and-associated-factors-that-influence-squat-performance-a-systematic-review
#10
Scott W Cheatham, Kyle R Stull, Mike Fantigrassi, Ian Montel
CONTEXT: The squat is a fundamental movement for weight lifting and sports performance. Both unilateral and bilateral squats are also used to assess transitional and dynamic lower extremity control. Common lower extremity conditions can have an influence on squat performance. Of interest, are the effects of hip musculoskeletal conditions and associated factors such as hip muscle pain, fatigue, and tightness on squat performance. Currently, there has been no appraisal of the evidence regarding the association of these conditions and associated factors on squat performance...
March 14, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28288121/a-genetic-system-to-study-plasmodium-falciparum-protein-function
#11
Jakob Birnbaum, Sven Flemming, Nick Reichard, Alexandra Blancke Soares, Paolo Mesén-Ramírez, Ernst Jonscher, Bärbel Bergmann, Tobias Spielmann
Current systems to study essential genes in the human malaria parasite Plasmodium falciparum are often inefficient and time intensive, and they depend on the genetic modification of the target locus, a process hindered by the low frequency of integration of episomal DNA into the genome. Here, we introduce a method, termed selection-linked integration (SLI), to rapidly select for genomic integration. SLI allowed us to functionally analyze targets at the gene and protein levels, thus permitting mislocalization of native proteins, a strategy known as knock sideways, floxing to induce diCre-based excision of genes and knocking in altered gene copies...
March 13, 2017: Nature Methods
https://www.readbyqxmd.com/read/28287901/the-acute-effects-of-bodyweight-suspension-exercise-on-muscle-activation-and-muscular-fatigue
#12
Trent E Cayot, Jakob D Lauver, Barry W Scheuermann
This investigation examined effects of two exercise modes (barbell, BB; bodyweight suspension, BWS) on muscle activation, resistance load, and fatigue. During session one, nine resistance-trained males completed an elbow flexion one-repetition maximum (1RM). During sessions two and three, subjects completed standing biceps curls to fatigue at 70% 1RM utilizing a randomized exercise mode. Surface electromyography (sEMG) recorded muscle activation of the biceps brachii, triceps brachii, anterior deltoid, posterior deltoid, rectus abdominis, and erector spinae...
March 13, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28286098/hepatic-gene-expression-profiles-of-a-non-model-cyprinid-barbus-plebejus-chronically-exposed-to-river-sediments
#13
Nadia Casatta, Fabrizio Stefani, Luigi Viganò
In this study, we characterized the gene expression responses of the Padanian barbel (Barbus plebejus), a native benthivorous cyprinid with a very compromised presence within the fish community of the River Po. Barbel juveniles were exposed in the laboratory to two river sediments reflecting an upstream/downstream gradient of increasing contamination and collected from one of the most anthropized tributaries of the River Po. After 7months of exposure, hepatic transcriptional changes that were diagnostic of sediment exposure were assessed...
March 9, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28282758/the-effects-of-barbell-load-on-countermovement-vertical-jump-power-and-net-impulse
#14
Peter D Mundy, Neal A Smith, Mike A Lauder, Jason P Lake
The aim of this study was to examine the effects of barbell load on countermovement vertical jump (CMJ) power and net impulse within a theoretically valid framework, cognisant of the underpinning force, temporal, and spatial components. A total of 24 resistance-trained rugby union athletes (average ± SD: age: 23.1 ± 3.4 years; height: 1.83 ± 0.05 m; body mass (BM): 91.3 ± 10.5 kg) performed maximal CMJ under 5 experimental conditions in a randomised, counterbalanced order: unloaded, and with additional loads of 25%, 50%, 75%, and 100% of BM...
September 26, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28281072/frequencies-of-erythrocyte-nuclear-abnormalities-and-of-leucocytes-in-the-fish-barbus-peloponnesius-correlate-with-a-pollution-gradient-in-the-river-bregalnica-macedonia
#15
Katerina Rebok, Maja Jordanova, Valentina Slavevska-Stamenković, Lozenka Ivanova, Vasil Kostov, Trajče Stafilov, Eduardo Rocha
Integrated chemical and biomarker approaches were performed to estimate if there is ongoing toxicity in the River Bregalnica, namely connected with the presence of metals. The study was performed in water, sediment, and barbel (Barbus peloponnesius), collected in two seasons, from two suspected polluted and one reference zones. The water analyses revealed higher mean values in polluted sites for most of the examined physicochemical parameters. Metal concentrations (Zn, Cu, Cd, Mn, Pb, and Fe) in water were more or less constant, whereas in sediment, they were higher at the two polluted locations...
March 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28276457/cd40-signalling-abrogates-induction-of-ror%C3%AE-t-treg-cells-by-intestinal-cd103-dcs-and-causes-fatal-colitis
#16
Christian Barthels, Ana Ogrinc, Verena Steyer, Stefanie Meier, Ferdinand Simon, Maria Wimmer, Andreas Blutke, Tobias Straub, Ursula Zimber-Strobl, Esther Lutgens, Peggy Marconi, Caspar Ohnmacht, Debora Garzetti, Bärbel Stecher, Thomas Brocker
Immune homeostasis in intestinal tissues depends on the generation of regulatory T (Treg) cells. CD103(+) dendritic cells (DCs) acquire microbiota-derived material from the gut lumen for transport to draining lymph nodes and generation of receptor-related orphan γt(+) (RORγt(+)) Helios(-)-induced Treg (iTreg) cells. Here we show CD40-signalling as a microbe-independent signal that can induce migration of CD103(+) DCs from the lamina propria (LP) to the mesenteric lymph nodes. Transgenic mice with constitutive CD11c-specific CD40-signalling have reduced numbers of CD103(+) DCs in LP and a low frequency of RORγt(+)Helios(-) iTreg cells, exacerbated inflammatory Th1/Th17 responses, high titres of microbiota-specific immunoglobulins, dysbiosis and fatal colitis, but no pathology is detected in other tissues...
March 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28238041/electrospinning-of-bioactive-wound-healing-nets
#17
Heinz C Schröder, Emad Tolba, Bärbel Diehl-Seifert, Xiaohong Wang, Werner E G Müller
The availability of appropriate dressings for treatment of wounds, in particular chronic wounds, is a task that still awaits better solutions than provided by currently applied materials. The method of electrospinning enables the fabrication of novel materials for wound dressings due to the high surface area and porosity of the electrospun meshes and the possibility to include bioactive ingredients. Recent results show that the incorporation of biologically active inorganic polyphosphate microparticles and microspheres and synergistically acting retinoids into electrospun polymer fibers yields biocompatible and antibacterial mats for potential dressings with improved wound-healing properties...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28230480/the-micro-bio-trojans-free-living-amoebae-as-reservoirs-for-human-pathogens-giant-viruses-and-other-surprises
#18
Bärbel Hauröder, Rolf Michel
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28229259/acidicapsa-ferrireducens-sp-nov-acidicapsa-acidiphila-sp-nov-and-granulicella-acidiphila-sp-nov-novel-acidobacteria-isolated-from-metal-rich-acidic-waters
#19
Carmen Falagán, Bärbel Foesel, Barrie Johnson
Four novel strains of Acidobacteria were isolated from water samples taken from pit lakes at two abandoned metal mines in the Iberian Pyrite Belt mining district, south-west Spain. Three of the isolates belong to the genus Acidicapsa (MCF9(T), MCF10(T), and MCF14) and one of them to the genus Granulicella (MCF40(T)). All isolates are moderately acidophilic (pH growth optimum 3.8-4.1) and mesophilic (temperature growth optima 30-32 °C). Isolates MCF10(T) and MCF40(T) grew at pH lower (<3.0) than previously reported for all other acidobacteria...
February 22, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28228678/oreoglanis-hponkanensis-a-new-sisorid-catfish-from-north-myanmar-actinopterygii-sisoridae
#20
Xiao-Yong Chen, Tao Qin, Zhi-Ying Chen
During a survey of the Mali Hka River drainage in Hponkanrazi Wildlife Sanctuary in December 2015, a new species was collected and is described herein as Oreoglanis hponkanensis. It is a member of the Oreoglanis siamensis species group and can be distinguished from its congeners in having a unique combination of the following characters: lower lip with median notch and posterior margin entire, caudal fin emarginate, nasal barbel reaching about half the distance to eye, tip of maxillary barbel rounded, posterior margin of maxillary barbel entire, absence of pale elliptical patches on sides of body below adipose fin, absence of patch on base of first dorsal fin ray, caudal fin brown with two round, bright orange patches in middle, branched dorsal fin rays 5, branched anal fin rays 2, vertebrae 40, pectoral fin surpassing pelvic fin origin, pelvic fin length 21-26% SL, caudal peduncle length 25-33% SL, caudal peduncle depth 3-5% SL, adipose fin base length 34-39% SL, and dorsal to adipose distance 12-16% SL...
2017: ZooKeys
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