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https://www.readbyqxmd.com/read/28197852/stereospecific-assignment-of-the-asparagine-and-glutamine-sidechain-amide-protons-in-proteins-from-chemical-shift-analysis
#1
Tobias Harsch, Philipp Schneider, Bärbel Kieninger, Harald Donaubauer, Hans Robert Kalbitzer
Side chain amide protons of asparagine and glutamine residues in random-coil peptides are characterized by large chemical shift differences and can be stereospecifically assigned on the basis of their chemical shift values only. The bimodal chemical shift distributions stored in the biological magnetic resonance data bank (BMRB) do not allow such an assignment. However, an analysis of the BMRB shows, that a substantial part of all stored stereospecific assignments is not correct. We show here that in most cases stereospecific assignment can also be done for folded proteins using an unbiased artificial chemical shift data base (UACSB)...
February 15, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28194722/mind-the-gap-temporal-discontinuities-in-observed-activity-streams-influence-perceived-duration-of-actions
#2
Bärbel Garsoffky, Markus Huff, Stephan Schwan
In everyday life, when observing activities taking place in our environment, we often shift our attention among several activities and therefore perceive each activity sequence piecemeal with temporal gaps in between. Two studies examined whether the length of these gaps influences the processing of the observed activities. Experiment 1 presented film clips depicting activities that were interrupted by either short or long gaps and asked participants to estimate how long the target action presented at the end of the clip would normally take if it were to take place in reality...
February 13, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28179989/bystander-effects-elicited-by-single-cell-photo-oxidative-blue-light-stimulation-in-retinal-pigment-epithelium-cell-networks
#3
Masaaki Ishii, Bärbel Rohrer
'Bystander effect' refers to the induction of biological effects in cells not directly targeted. The retinal pigment epithelium consists of hexagonal cells, forming a monolayer interconnected by gap junctions (GJs). Oxidative stress initiated in an individual cell by photostimulation (488 nm) triggered changes in reactive oxygen species (ROS), Ca(2+) and mitochondrial membrane potential (ψm). The Ca(2+) signal was transmitted to neighboring cells slowly and non-uniformly; the ROS signal spread fast and radially...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28178358/substrate-analogous-inhibitors-exert-antimalarial-action-by-targeting-the-plasmodium-lactate-transporter-pffnt-at-nanomolar-scale
#4
André Golldack, Björn Henke, Bärbel Bergmann, Marie Wiechert, Holger Erler, Alexandra Blancke Soares, Tobias Spielmann, Eric Beitz
Resistance against all available antimalarial drugs calls for novel compounds that hit unexploited targets in the parasite. Here, we show that the recently discovered Plasmodium falciparum lactate/proton symporter, PfFNT, is a valid druggable target, and describe a new class of fluoroalkyl vinylogous acids that potently block PfFNT and kill cultured parasites. The original compound, MMV007839, is derived from the malaria box collection of potent antimalarials with unknown targets and contains a unique internal prodrug principle that reversibly switches between a lipophilic transport form and a polar, substrate-analogous active form...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28173829/cloning-expression-and-molecular-characterization-of-a-cystoisospora-suis-specific-uncharacterized-merozoite-protein
#5
Aruna Shrestha, Nicola Palmieri, Ahmed Abd-Elfattah, Bärbel Ruttkowski, Marc Pagès, Anja Joachim
BACKGROUND: The genome of the apicomplexan parasite Cystoisospora suis (syn. Isospora suis) has recently been sequenced and annotated, opening the possibility for the identification of novel therapeutic targets against cystoisosporosis. It was previously proposed that a 42 kDa uncharacterized merozoite protein, encoded by gene CSUI_005805, might be a relevant vaccine candidate due to its high immunogenic score, high expression level and species-specificity as determined in silico. METHODS: The 1170 bp coding sequence of the CSUI_005805 gene was PCR amplified and cloned into the bacterial expression vector pQE-31...
February 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28170449/a-systematic-review-of-surface-electromyography-analyses-of-the-bench-press-movement-task
#6
Petr Stastny, Artur Gołaś, Dusan Blazek, Adam Maszczyk, Michał Wilk, Przemysław Pietraszewski, Miroslav Petr, Petr Uhlir, Adam Zając
BACKGROUND: The bench press exercise (BP) plays an important role in recreational and professional training, in which muscle activity is an important multifactorial phenomenon. The objective of this paper is to systematically review electromyography (EMG) studies performed on the barbell BP exercise to answer the following research questions: Which muscles show the greatest activity during the flat BP? Which changes in muscle activity are related to specific conditions under which the BP movement is performed? STRATEGY: PubMed, Scopus, Web of Science and Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library were searched through June 10, 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28168224/lifestyle-and-horizontal-gene-transfer-mediated-evolution-of-mucispirillum-schaedleri-a-core-member-of-the-murine-gut-microbiota
#7
Alexander Loy, Carina Pfann, Michaela Steinberger, Buck Hanson, Simone Herp, Sandrine Brugiroux, João Carlos Gomes Neto, Mark V Boekschoten, Clarissa Schwab, Tim Urich, Amanda E Ramer-Tait, Thomas Rattei, Bärbel Stecher, David Berry
Mucispirillum schaedleri is an abundant inhabitant of the intestinal mucus layer of rodents and other animals and has been suggested to be a pathobiont, a commensal that plays a role in disease. In order to gain insights into its lifestyle, we analyzed the genome and transcriptome of M. schaedleri ASF 457 and performed physiological experiments to test traits predicted by its genome. Although described as a mucus inhabitant, M. schaedleri has limited capacity for degrading host-derived mucosal glycans and other complex polysaccharides...
January 2017: MSystems
https://www.readbyqxmd.com/read/28168014/complete-genome-sequence-of-pseudoalteromonas-phage-vb_psps-h40-1-formerly-h40-1-that-infects-pseudoalteromonas-sp-strain-h40-and-is-used-as-biological-tracer-in-hydrological-transport-studies
#8
René Kallies, Bärbel Kiesel, Matthias Schmidt, Johannes Kacza, Nawras Ghanem, Anja Narr, Jakob Zopfi, Lukas Y Wick, Jörg Hackermüller, Hauke Harms, Antonis Chatzinotas
Pseudoalteromonas phage vB_PspS-H40/1 is a lytic phage that infects Pseudoalteromonas sp. strain H40. Both, the phage and its host were isolated in the 1970s from seawater samples collected from the North Sea near the island of Helgoland, Germany. The phage particle has an icosahedral capsid with a diameter of ~43 to 45 nm and a long non-contractile tail of ~68 nm in length, a typical morphology for members of the Siphoviridae family. The linear dsDNA genome of Pseudoalteromonas phage vB_PspS-H40/1 has a sequence length of 45,306 bp and a GC content of 40...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28161402/the-genome-of-the-protozoan-parasite-cystoisospora-suis-and-a-reverse-vaccinology-approach-to-identify-vaccine-candidates
#9
Nicola Palmieri, Aruna Shrestha, Bärbel Ruttkowski, Tomas Beck, Claus Vogl, Fiona Tomley, Damer P Blake, Anja Joachim
Vaccine development targeting protozoan parasites remains challenging, partly due to the complex interactions between these eukaryotes and the host immune system. Reverse vaccinology is a promising approach for direct screening of genome sequence assemblies for new vaccine candidate proteins. Here, we applied this paradigm to Cystoisospora suis, an apicomplexan parasite that causes enteritis and diarrhea in suckling piglets and economic losses in pig production worldwide. Using Next Generation Sequencing we produced an ∼84Mb sequence assembly for the C...
February 2, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28151781/acute-effects-of-eccentric-overload-on-concentric-front-squat-performance
#10
Cameron N Munger, David C Archer, Whitney D Leyva, Megan A Wong, Jared W Coburn, Pablo B Costa, Lee E Brown
Eccentric overload is used to enhance performance. The purpose of this study was to investigate the acute effects of eccentric overload on concentric front squat performance. Twenty resistance-trained males (age=23.80±1.82yrs, ht=176.95±5.21cm, mass=83.49±10.43kg, 1 Repetition Maximum [1RM] front squat=131.02±21.32kg) volunteered. A dynamic warm-up and warm-up sets of front squat were performed. Eccentric hooks were added to the barbell. They descended for 3 seconds, until eccentric hooks released, and performed the concentric phase as fast as possible...
January 30, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28151780/electromyographic-comparison-of-barbell-deadlift-hex-bar-deadlift-and-hip-thrust-exercises-a-cross-over-study
#11
Vidar Andersen, Marius Steiro Fimland, Dag-Andrè Mo, Vegard Moe Iversen, Torbjørn Vederhus, Lars Richard Rockland Hellebø, Kristina Isabel Nordaune, Atle Hole Saeterbakken
The aim of the study was to compare the muscle activation level of the gluteus maximus, biceps femoris and erector spinae in the hip thrust, barbell deadlift and hex bar deadlift; each of which are compound resisted hip-extension exercises. After two familiarization sessions, 13 resistance-trained men performed a 1-RM in all three exercises in one session, in randomized and counterbalanced order. The whole ascending movement (concentric phase), as well as its lower and upper part (whole movement divided in two), were analyzed...
January 30, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28149424/effect-of-8-weeks-of-free-weight-and-machine-based-strength-training-on-strength-and-power-performance
#12
Klaus Wirth, Michael Keiner, Hagen Hartmann, Andre Sander, Christoph Mickel
The aim of this study was to evaluate the effectiveness of free-weight and machine-based exercises to increase different strength and speed-strength variables. One hundred twenty male participants (age: 23.8 ± 2.5 years; body height: 181.0 ± 6.8 cm; body mass: 80.2 ± 8.9 kg) joined the study. The 2 experimental groups completed an 8 week periodized strength training program that included 2 training sessions per week. The exercises that were used in the strength training programs were the parallel barbell squat and the leg press...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28149414/neuroendocrine-responses-and-body-composition-changes-following-resistance-training-under-normobaric-hypoxia
#13
Jakub Chycki, Miłośz Czuba, Artur Gołaś, Adam Zając, Olga Fidos-Czuba, Adrian Młynarz, Wojciech Smółka
The aim of the present study was to evaluate the effects of a 6 week resistance training protocol under hypoxic conditions (FiO2 = 12.9%, 4000 m) on muscle hypertrophy. The project included 12 resistance trained male subjects, randomly divided into two experimental groups. Group 1 (n = 6; age 21 ± 2.4 years; body height [BH] 178.8 ± 7.3 cm; body mass [BM] 80.6 ± 12.3 kg) and group 2 (n = 6; age 22 ± 1.5 years; BH 177.8 ± 3.7cm; BM 81.1 ± 7.5 kg). Each group performed resistance exercises alternately under normoxic and hypoxic conditions (4000 m) for 6 weeks...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28132095/updated-prevalence-rates-of-overweight-and-obesity-in-4-to-10-year-old-children-in-germany-results-from-the-telephone-based-kiggs-wave-1-after-correction-for-bias-in-parental-reports
#14
Anna-Kristin Brettschneider, Anja Schienkiewitz, Steffen Schmidt, Ute Ellert, Bärbel-Maria Kurth
: The nationwide 'German Health Interview and Examination Survey for Children and Adolescents' (KiGGS), conducted in 2003-2006, showed an increase in the prevalence rates of overweight and obesity compared to the early 1990s, indicating the need for regular monitoring. Recently, a follow-up-KiGGS Wave 1 (2009-2012)-was carried out as a telephone-based survey, providing parent-reported height and weight from 5155 children aged 4-10 years. Since parental reports lead to a bias in prevalence rates of weight status, a correction is needed...
January 28, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28132078/targeting-the-tight-junction-protein-zonula-occludens-1-with-the-connexin43-mimetic-peptide-%C3%AE-ct1-reduces-vegf-dependent-rpe-pathophysiology
#15
Elisabeth Obert, Randy Strauss, Carlene Brandon, Christina Grek, Gautam Ghatnekar, Robert Gourdie, Bärbel Rohrer
: A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1) is a major structural protein of intercellular junctions. A connexin43-based peptide mimetic, αCT1, was developed to competitively block interactions at the PDZ2 domain of ZO-1, thereby inhibiting ligands that selectively bind to this domain...
January 28, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28128973/the-role-of-volume-load-in-strength-and-absolute-endurance-adaptations-in-adolescent-s-performing-high-or-low-load-resistance-training
#16
RANDOMIZED CONTROLLED TRIAL
James Steele, James P Fisher, Ari R Assunção, Martim Bottaro, Paulo Gentil
This study compared high- (HL) and low-load (LL) resistance training (RT) on strength, absolute endurance, volume-load, and their relationships in untrained adolescents. Thirty-three untrained adolescents of both sexes (males, n = 17; females, n = 16; 14 ± 1 years) were randomly assigned into either (i) HL (n = 17): performing 3 sets of 4-6 repetitions to momentary concentric failure; or (ii) LL (n = 16): performing 2 sets of 12-15 repetitions to momentary concentric failure. RT was performed for 2×/week for 9 weeks...
February 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28097928/validity-and-reliability-of-a-novel-iphone-app-for-the-measurement-of-barbell-velocity-and-1rm-on-the-bench-press-exercise
#17
Carlos Balsalobre-Fernández, David Marchante, Mario Muñoz-López, Sergio L Jiménez
The purpose of this study was to analyse the validity and reliability of a novel iPhone app (named: PowerLift) for the measurement of mean velocity on the bench-press exercise. Additionally, the accuracy of the estimation of the 1-Repetition maximum (1RM) using the load-velocity relationship was tested. To do this, 10 powerlifters (Mean (SD): age = 26.5 ± 6.5 years; bench press 1RM · kg(-1) = 1.34 ± 0.25) completed an incremental test on the bench-press exercise with 5 different loads (75-100% 1RM), while the mean velocity of the barbell was registered using a linear transducer (LT) and Powerlift...
January 18, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28034991/impact-of-flt3-itd-diversity-on-response-to-induction-chemotherapy-in-patients-with-acute-myeloid-leukemia
#18
Mike Fischer, Ulf Schnetzke, Bärbel Spies-Weisshart, Mario Walther, Maximilian Fleischmann, Inken Hilgendorf, Andreas Hochhaus, Sebastian Scholl
No abstract text is available yet for this article.
December 29, 2016: Haematologica
https://www.readbyqxmd.com/read/28031767/mechanical-differences-between-barbell-and-body-optimum-power-loads-in-the-jump-squat-exercise
#19
Irineu Loturco, Lucas A Pereira, Vinicius Zanetti, Katia Kitamura, César C Cal Abad, Ronaldo Kobal, Fabio Y Nakamura
This study compared the values of bar-peak force (PFBar) and power (PPBar), body-peak force (PFBody) and power (PPBody) and bar-mean propulsive power (MPPBar) in different jump-squat (JS) conditions: unloaded condition (UC); bar-loaded condition (BLC) and optimum bar-MPP condition (OBC). Twenty-five soccer players performed the JS using a bar with negligible mass (UC), using the Smith-machine bar (BLC) and using the load capable of maximizing the bar-MPP (OBC). The PFBody was significantly higher in the UC (2847...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28030531/does-focus-of-attention-improve-snatch-lift-kinematics
#20
Kyle S Schutts, Will Wu, Anthony Vidal, Jamie Hiegel, James Becker
Recent motor control literature has demonstrated that using verbal instructions to direct a performer's attention externally (i.e. toward the movement outcome) enhances motor skill performance. The purpose of this study was to investigate how an athlete's focus of attention impacts kinematic performance of the snatch. Using a counterbalanced within-participant design, 12 competitively trained athletes (8 male, 4 female) performed 2 instructional blocks of 3 snatch repetitions at 80% of their most recent training 1RM...
December 24, 2016: Journal of Strength and Conditioning Research
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