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https://www.readbyqxmd.com/read/29436510/hidden-markov-models-for-monitoring-circadian-rhythmicity-in-telemetric-activity-data
#1
Qi Huang, Dwayne Cohen, Sandra Komarzynski, Xiao-Mei Li, Pasquale Innominato, Francis Lévi, Bärbel Finkenstädt
Wearable computing devices allow collection of densely sampled real-time information on movement enabling researchers and medical experts to obtain objective and non-obtrusive records of actual activity of a subject in the real world over many days. Our interest here is motivated by the use of activity data for evaluating and monitoring the circadian rhythmicity of subjects for research in chronobiology and chronotherapeutic healthcare. In order to translate the information from such high-volume data arising we propose the use of a Markov modelling approach which (i) naturally captures the notable square wave form observed in activity data along with heterogeneous ultradian variances over the circadian cycle of human activity, (ii) thresholds activity into different states in a probabilistic way while respecting time dependence and (iii) gives rise to circadian rhythm parameter estimates, based on probabilities of transitions between rest and activity, that are interpretable and of interest to circadian research...
February 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29436289/a-comparative-analysis-of-lumbar-spine-mechanics-during-barbell-and-crate-lifting-implications-for-occupational-lifting-task-assessments
#2
Jackie D Zehr, Danielle R Carnegie, Timothy N Welsh, Tyson A C Beach
PURPOSE: To compare the effects of object handled and handgrip used on lumbar spine motion and loading during occupational lifting task simulations. METHODS: Eight male and eight female volunteers performed barbell and crate lifts with a pronated (barbell) and neutral (crate) handgrip. The mass of barbells/crates lifted was identical across the objects and fixed at 11.6 kg and 9.3 kg for men and women, respectively. The initial heights of barbells/crates were individualized to mid-shank level...
February 13, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29408759/changes-in-intermediate-metabolism-and-oxidative-balance-parameters-in-sexually-matured-three-barbeled-catfishes-exposed-to-herbicides-from-rice-crops-roundup%C3%A2-primoleo%C3%A2-and-facet%C3%A2
#3
Tanilene Sotero Pinto Persch, Patrícia Rodrigues da Silva, Sarah Helen Dias Dos Santos, Betânia Souza de Freitas, Guendalina Turcato Oliveira
This study analyzed the effect of different concentrations of herbicides (Facet®, Primoleo®, and Roundup®) on metabolism and oxidative balance (superoxide dismutase and catalase activity, lipid peroxidation) in the gills, liver, kidneys, and tail muscle of adult catfish. All herbicides caused protein depletion in gills, increased glycogen and triacylglycerol consumption in the liver, and changes in muscle glycogen. Roundup® and Primoleo® stimulated lipid deposition in the liver, while Roundup® and Facet® stimulated lipid consumption in gills...
January 9, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29391272/identification-of-co-occurrence-in-a-patient-with-dent-s-disease-and-ada2-deficiency-by-exome-sequencing
#4
Roman Günthner, Matias Wagner, Tobias Thurm, Sabine Ponsel, Julia Höfele, Bärbel Lange-Sperandio
Patients with co-occurrence of two independent pathologies pose a challenge for clinicians as the phenotype often presents as an unclear syndrome. In these cases, exome sequencing serves as a powerful instrument to determine the underlying genetic causes. Here, we present the case of a 4-year old boy with proteinuria, microhematuria, hypercalciuria, nephrocalcinosis, livedo-like rash, recurrent abdominal pain, anemia and continuously elevated CRP. Single exome sequencing revealed the pathogenic nonsense mutation p...
January 29, 2018: Gene
https://www.readbyqxmd.com/read/29365286/effect-of-cluster-set-warm-up-configurations-on-sprint-performance-in-collegiate-male-soccer-players
#5
Brett S Nickerson, Gerald T Mangine, Tyler D Williams, Ismael A Martinez
The purpose of this study was to determine if back squat cluster sets (CS) with varying inter-repetition rest periods would potentiate greater sprint performance compared to a traditional set parallel back squat in collegiate soccer players. Twelve collegiate male soccer players (21.0 ± 2.0 years; 180.0 ± 9.0 cm; 79.0 ± 9.5 kg) performed a 20-meter sprint prior to (PRE) a potentiation complex and at 1-, 4-, 7-, and 10-minutes post-exercise on three separate, randomized occasions. On each occasion, the potentiation complex consisted of 1 set of 3 repetitions at 85% one-repetition maximum (1RM) for the traditional parallel back squat...
January 24, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29364062/water-filled-training-tubes-increase-core-muscle-activation-and-somatosensory-control-of-balance-during-squat
#6
Massimiliano Ditroilo, Rory O'Sullivan, Brian Harnan, Aislinn Crossey, Beth Gillmor, William Dardis, Adam Grainger
This study examined trunk muscle activation, balance and proprioception while squatting with a water-filled training tube (WT) and a traditional barbell (BB), with either closed (CE) or open eyes (OE). Eighteen male elite Gaelic footballers performed an isometric squat under the following conditions: BB-OE, BB-CE, WT-OE and WT-CE. The activity of rectus abdominis (RA), external oblique (EO) and multifidus (MF) was measured using electromyography, along with sway of the centre of pressure (CoP) using a force platform...
January 24, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29349797/efficacy-and-toxicity-of-praziquantel-in-helminth-infected-barbel-barbus-barbus-l
#7
E Zuskova, V Piackova, J Machova, L Chupani, C Steinbach, A Stara, J Velisek
This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (PZQ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post-treatment. The estimated 96-hr LC50 of PZQ was 28.6 mg/L. For evaluation of efficacy, barbel naturally infected with D. spathaceum were exposed to a 10 and 20 mg/L PZQ 4-day bath treatment. Both concentrations were 100% effective against D...
January 19, 2018: Journal of Fish Diseases
https://www.readbyqxmd.com/read/29344807/inhibition-of-bone-resorption-by-bisphosphonates-interferes-with-orthodontically-induced-midpalatal-suture-expansion-in-mice
#8
Till Koehne, Bärbel Kahl-Nieke, Michael Amling, Heike Korbmacher-Steiner
OBJECTIVES: Craniofacial sutures are important growth sites for skull development and are sensitive to mechanical stress. In order to determine the role of bone resorption in stress-mediated sutural bone growth, midpalatal suture expansion was performed in mice receiving alendronate, an anti-resorptive bisphosphonate. MATERIALS AND METHODS: The midpalatal sutures of 8-week-old C57BL/6 mice were expanded by orthodontic wires over the period of 2 weeks. Mice with maxillary expansion without drug treatment as well as untreated animals served as controls...
January 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29339070/involvement-of-interferon-regulatory-factor-3-from-the-barbel-chub-squaliobarbus-curriculus-in-the-immune-response-against-grass-carp-reovirus
#9
Ronghua Wang, Yaoguo Li, Zhiyu Zhou, Qiaolin Liu, Lingbing Zeng, Tiaoyi Xiao
The barbel chub Squaliobarbus curriculus is an important commercial fish species in China, and has shown significant resistance to grass carp reovirus (GCRV). In this study, the cDNA sequence of interferon regulatory factors 3 (IRF3) from Squaliobarbus curriculus, designated as ScIRF3, was cloned, and its effect against GCRV was investigated. The full-length 1837 base pair (bp) cDNA of ScIRF3 contained a complete open reading frame of 1374 bp and encoded a putative polypeptide of 457 amino acid residues. The ScIRF3 protein contained conserved domains, including an N-terminal DNA-binding domain, a C-terminal IRF association domain, and a serine-rich domain...
January 12, 2018: Gene
https://www.readbyqxmd.com/read/29334580/the-power-load-relationship-during-a-countermovement-jump-a-joint-level-analysis
#10
Kym J Williams, Dale W Chapman, Elissa J Phillips, Nick Ball
This study aimed to investigate if hip, knee and ankle peak power is influenced by the relative load lifted, altering the joint and system load-power relationship during a countermovement jump (CMJ). Twenty-Three male national representative athletes (age: 20.3 ± 3.1y, squat 1RM: 133.8 ± 24.8kg) completed three CMJs at relative barbell loads of 0, 10, 20, 30 and 40% of an athlete's estimated back squat 1RM. Ground reaction force and joint kinematics were captured using a 16 camera motion capture array integrated with two in ground tri-axial force plates...
January 12, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29327434/a-fast-and-reliable-method-for-monitoring-of-prophage-activating-chemicals
#11
Juan Xu, Bärbel Kiesel, René Kallies, Feng-Lei Jiang, Yi Liu, Thomas Maskow
Bacteriophages, that is viruses that infect bacteria, either lyse bacteria directly or integrate their genome into the bacterial genome as so-called prophages, where they remain at a silent state. Both phages and bacteria are able to survive in this state. However, prophages can be reactivated with the introduction of chemicals, followed by the release of a high number of phage particles, which could infect other bacteria, thus harming ecosystems by a viral bloom. The basics for a fast, automatable analytical method for the detection of prophage-activating chemicals are developed and successfully tested here...
January 12, 2018: Microbial Biotechnology
https://www.readbyqxmd.com/read/29324228/lactateing-salmonella-a-host-derived-fermentation-product-fuels-pathogen-growth
#12
Bärbel Stecher, Kirsten Jung
Infection by Salmonella enterica serovar Typhimurium is accompanied by dysbiosis and a decrease of microbiota-derived butyrate. In this issue of Cell Host & Microbe, Gillis et al. (2018) demonstrate that the lack of butyrate reprograms colonic epithelial metabolism toward lactate fermentation. Lactate is then used as a respiratory electron donor, supporting Salmonella growth and thus promoting infection.
January 10, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29289384/the-vaccine-hesitancy-scale-psychometric-properties-and-validation
#13
Gilla K Shapiro, Ovidiu Tatar, Eve Dube, Rhonda Amsel, Barbel Knauper, Anila Naz, Samara Perez, Zeev Rosberger
INTRODUCTION: The SAGE Working Group on Vaccine Hesitancy developed a vaccine hesitancy measure, the Vaccine Hesitancy Scale (VHS). This scale has the potential to aid in the advancement of research and immunization policy but has not yet been psychometrically evaluated. METHODS: Using a cross-sectional design, we collected self-reported survey data from a large national sample of Canadian parents from August to September 2016. An online questionnaire was completed in English or French...
December 27, 2017: Vaccine
https://www.readbyqxmd.com/read/29274115/a-novel-desmin-des-indel-mutation-causes-severe-atypical-cardiomyopathy-in-combination-with-atrioventricular-block-and-skeletal-myopathy
#14
Ilona Schirmer, Mareike Dieding, Bärbel Klauke, Andreas Brodehl, Anna Gaertner-Rommel, Volker Walhorn, Jan Gummert, Uwe Schulz, Lech Paluszkiewicz, Dario Anselmetti, Hendrik Milting
BACKGROUND: DES mutations cause different cardiac and skeletal myopathies. Most of them are missense mutations. METHODS: Using a next-generation sequencing cardiac 174 gene panel, we identified a novel heterozygous in-frame indel mutation (DES-c.493_520del28insGCGT, p.Q165_A174delinsAS) in a Caucasian patient with cardiomyopathy in combination with atrioventricular block and skeletal myopathy. This indel mutation is located in the coding region of the first exon...
December 23, 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29259807/weaker-lower-extremity-muscle-strength-predicts-traumatic-knee-injury-in-youth-female-but-not-male-athletes
#15
Sofia Ryman Augustsson, Eva Ageberg
Background: The role of lower extremity (LE) muscle strength for predicting traumatic knee injury in youth athletes is largely unknown. Aims: The aim was to investigate the influence of LE muscle strength on traumatic knee injury in youth female and male athletes. Methods: 225 athletes (40% females) from sport senior high schools in Sweden were included in this case-control study. The athletes recorded any traumatic knee injury that had occurred during their high-school period in a web-based injury form...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29245728/a-new-species-of-i-pimelodella-i-siluriformes-heptapteridae-from-the-guiana-shield-brazil
#16
Veronica Slobodian, Alberto Akama, Guilherme Moreira Dutra
A new species of Pimelodella is described from the Rio Ipitinga, Rio Jari basin, a left bank tributary of the Rio Amazonas in Brazil. The new species is diagnosed from all congeners by having a dark oval mark on the humeral region. It also differs from all congeners by a unique set of characters, including the presence of 47 to 49 total vertebrae, unpigmented areas dorsally and ventrally adjacent to the dark midlateral stripe, and maxillary barbels reaching at least to vertical through caudal fin insertion...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245684/revision-of-the-horseface-loaches-cobitidae-i-acantopsis-i-with-descriptions-of-three-new-species-from-southeast-asia
#17
David A Boyd, Patchara Nithirojpakdee, Gridsada Deein, Chavalit Vidthayanon, Chaiwut Grudpan, Weerapongse Tangjitjaroen, John M Pfeiffer, Zachary S Randall, Tippamas Srisombat, Lawrence M Page
Acantopsis (Cobitidae) is revised based on analysis of morphological and molecular data. Four of the six available names, A. dialuzona, A. spectabilis, A. octoactinotos, and A. thiemmedhi, are valid, and three new species, A. rungthipae, A. dinema, and A. ioa, are described. All species are described morphologically, distributions are mapped, and relationships are discussed for those for which molecular data (CO1, RAG1) are available. Labial barbels, color pattern, and meristic counts are the most diagnostic features...
October 31, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245624/redescription-and-new-records-of-jansen-s-goatfish-i-parupeneus-jansenii-i-mullidae-from-the-western-pacific-and-eastern-indian-ocean
#18
Franz Uiblein, Tuan Anh Hoang, Daniel Gledhill
For Jansen's goatfish, Parupeneus jansenii (Mullidae), taxonomic knowledge has been rather poor and occurrence information restricted to a few localities only, with verified records from northern Sulawesi and Sunda Street (Indonesia), and Luzon (Philippines). This species is here included in the so-called "heptacanthus" group together with the Indo-Pacific cinnabar goatfish, P. heptacanthus, and five Indian Ocean congenerics, based on an evenly, symmetrically rounded posterior maxilla margin and similarities in meristic characters and preserved colour...
November 8, 2017: Zootaxa
https://www.readbyqxmd.com/read/29245502/early-ontogeny-of-i-tatia-neivai-i-ihering-1930-osteichthyes-auchenipteridae-a-small-catfish-from-neotropical-region
#19
Joyce Andreia Dos Santos, Regina Meneguetti Passos, Angelo Antonio Agostinho, Andréa Bialetzki
The early development of Tatia neivai (Ihering 1930) was analyzed (i) to characterize its morphological, morphometric and meristic development; and (ii) to examine its possible ontogenic variation as a result of the development of structures and organs necessary for survival. Samples were collected in the Baía River, basin Paraná River, Mato Grosso do Sul State, Brazil, between February 1999 and April 2000. After identification, the specimens were separated according to notochord development, and the morphometric and meristic characters were measured and counted...
November 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29238597/effects-of-nine-weeks-isokinetic-training-on-power-golf-kinematics-and-driver-performance-in-pre-elite-golfers
#20
James Parker, Charlie Lagerhem, John Hellström, M Charlotte Olsson
Background: It has previously been shown that isotonic strength training can improve driver performance among golfers, though few studies have investigated effects of strength training on swing kinematics together with driver performance. In this study we investigated whether isokinetic rotational training could improve driver performance and swing kinematic variables amongst elite golfers. Methods: Twenty competitive pre-elite golfers (handicap better than -3.0), 13 men and 7 women, were split into two groups, one group received the isokinetic power training (IK) alongside their normal isotonic pre-season strength-training and the other group continued with their normal isotonic pre-season strength-training regime (IT)...
2017: BMC Sports Science, Medicine and Rehabilitation
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