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https://www.readbyqxmd.com/read/28109179/quantitative-and-integrative-analysis-of-paracrine-hepatocyte-activation-by-non-parenchymal-cells-upon-lipopolysaccharide-induction
#1
Katharina Beuke, Frank A Schildberg, Federico Pinna, Ute Albrecht, Roman Liebe, Michaela Bissinger, Peter Schirmacher, Steven Dooley, Johannes G Bode, Percy A Knolle, Ursula Kummer, Kai Breuhahn, Sven Sahle
Gut-derived bacterial lipopolysaccharides (LPS) stimulate the secretion of tumor necrosis factor (TNF) from liver macrophages (MCs), liver sinusoidal endothelial cells (LSECs), and hepatic stellate cells (HSCs), which control the acute phase response in hepatocytes through activation of the NF-κB pathway. The individual and cooperative impact of non-parenchymal cells on this clinically relevant response has not been analysed in detail due to technical limitations. To gain an integrative view on this complex inter- and intracellular communication, we combined a multi-scale mathematical model with quantitative, time-resolved experimental data of different primary murine liver cell types...
January 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28109024/computer-assisted-technologies-used-in-oral-rehabilitation-and-the-clinical-documentation-of-alleged-advantages-a-systematic-review
#2
REVIEW
Asbjørn Jokstad
The objective of this systematic review is to identify current computer-assisted technologies used for managing patients with a need to re-establish craniofacial appearance, subjective discomfort and stomatognathic function, and the extent of their clinical documentation. Electronic search strategies were used for locating clinical studies in MEDLINE through PubMed and in the Cochrane library, and in the grey literature through searches on Google Scholar. The searches for commercial digital products for use in oral rehabilitation resulted in identifying 225 products per November 2016, used for patient diagnostics, communication and therapy purposes, and for other computer-assisted applications in context with oral rehabilitation...
January 21, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28108980/the-influence-of-macrophages-on-mesenchymal-stromal-cell-therapy-passive-or-aggressive-agents
#3
REVIEW
Fiona Carty, Bernard P Mahon, Karen English
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date, however, recently a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to better design MSC therapies and clinical studies...
January 20, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28108642/the-potential-role-for-smartphones-among-older-adults-with-chronic-noncancer-pain-a-qualitative-study
#4
Joshua E Richardson, Jennifer I Lee, Anita Nirenberg, M Carrington Reid
: OBJECTIVE : To determine the role that smartphones may play in supporting older adults with chronic noncancer pain (CNCP) in order to improve pain management in this expanding population. DESIGN:  Qualitative study. SETTING:  One academically affiliated primary care practice serving older adults with CNCP in New York City. SUBJECTS : Thirteen older adults (age 65-85 years) with CNCP on chronic opioid therapy, that is, continuous use of opioids for at least six months...
January 20, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28108429/toward-patient-centered-telerehabilitation-design-understanding-chronic-pain-patients-preferences-for-web-based-exercise-telerehabilitation-using-a-discrete-choice-experiment
#5
Karlijn Cranen, Catharina Gm Groothuis-Oudshoorn, Miriam Mr Vollenbroek-Hutten, Maarten J IJzerman
BACKGROUND: Patient-centered design that addresses patients' preferences and needs is considered an important aim for improving health care systems. At present, within the field of pain rehabilitation, patients' preferences regarding telerehabilitation remain scarcely explored and little is known about the optimal combination between human and electronic contact from the patients' perspective. In addition, limited evidence is available about the best way to explore patients' preferences...
January 20, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28108359/synaptic-targets-chronic-alcohol-actions
#6
REVIEW
Marisa Roberto, Florence Varodayan
Alcohol acts on numerous cellular and molecular targets to regulate neuronal communication within the brain. Chronic alcohol exposure and acute withdrawal generate prominent neuroadaptations at synapses, including compensatory effects on the expression, localization and function of synaptic proteins, channels and receptors. The present article reviews the literature describing the synaptic effects of chronic alcohol exposure and their relevance for synaptic transmission in the central nervous system. This review is not meant to be comprehensive, but rather to highlight the effects that have been observed most consistently and that are thought to contribute to the development of alcohol dependence and the negative aspects of withdrawal...
January 17, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28108169/learning-to-manage-vasoactive-drugs-a-qualitative-interview-study-with-critical-care-nurses
#7
Marie Häggström, Ann-Christin Bergsman, Ulrika Månsson, Malin Rising Holmström
OBJECTIVE: Being a nurse in an intensive care unit entails caring for seriously ill patients. Vasoactive drugs are one of the tools that are used to restore adequate circulation. Critical care nurses often manage and administer these potent drugs after medical advice from physicians. AIM: To describe the experiences of critical care nurses learning to manage vasoactive drugs, and to highlight the competence required to manage vasoactive drugs. RESEARCH METHODOLOGY/SETTING: Twelve critical care nurses from three hospitals in Sweden were interviewed...
January 17, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28107337/e-cigarettes-and-smoking-cessation-a-primer-for-oncology-clinicians
#8
Yanina Zborovskaya
BACKGROUND: Electronic cigarettes 
(e-cigarettes) are a psychosocial phenomenon of the 21st century with serious implications to public and individual health. The significant increase of their popularity and use has raised concerns in the healthcare community regarding their potential benefits and harm, particularly their use as a smoking cessation methodology. 
. OBJECTIVES: Current knowledge is presented about e-cigarettes, including the clinical implications of their use, and associated controversies are analyzed...
February 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28107297/nursing-care-management-influence-on-bundled-payments
#9
Shaynie Lentz, Brenda Luther
Fragmented and uncoordinated care is the third highest driver of U.S. healthcare costs. Although less than 10% of patients experience uncoordinated care, these patients represent 36% of total healthcare costs; care management interaction makes a significant impact on the utilization of healthcare dollars. A literature search was conducted to construct a model of care coordination for elective surgical procedures by collecting best practices for acute, transitions, and post-acute care periods. A case study was used to demonstrate the model developed...
January 2017: Orthopaedic Nursing
https://www.readbyqxmd.com/read/28107159/caring-for-the-trafficked-patient-ethical-challenges-and-recommendations-for-health-care-professionals
#10
Wendy L Macias-Konstantopoulos
Human trafficking is an egregious human rights violation with profound negative physical and psychological consequences, including communicable diseases, substance use disorders, and mental illnesses. The health needs of this population are multiple, complex, and influenced by past and present experiences of abuse, neglect, and exploitation. Effective health care services for trafficked patients require clinicians to consider individual patients' needs, wishes, goals, priorities, risks, and vulnerabilities as well as public health implications and even resource allocation...
January 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28107106/news-reports-and-their-role-in-child-agricultural-injury-prevention
#11
Barbara Marlenga, Richard L Berg, Susan S Gallagher
OBJECTIVES: The news media can be important sources of health information. We examined news reports of child agricultural injuries to assess what was reported and to evaluate potential implications for health communication and surveillance efforts. METHODS: A content analysis was conducted of a convenience sample of 113 US news reports from 2012 to 2014 involving agricultural injuries to children less than 18 years-of-age. The data collection instrument included basic elements of injury surveillance, as well as variables related to injury causation and prevention...
January 20, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28106843/underwater-electromagnetic-sensor-networks-part-i-link-characterization
#12
Gara Quintana-Díaz, Pablo Mena-Rodríguez, Iván Pérez-Álvarez, Eugenio Jiménez, Blas-Pablo Dorta-Naranjo, Santiago Zazo, Marina Pérez, Eduardo Quevedo, Laura Cardona, J Joaquín Hernández
Underwater Wireless Sensor Networks (UWSNs) using electromagnetic (EM) technology in marine shallow waters are examined, not just for environmental monitoring but for further interesting applications. Particularly, the use of EM waves is reconsidered in shallow waters due to the benefits offered in this context, where acoustic and optical technologies have serious disadvantages. Sea water scenario is a harsh environment for radiocommunications, and there is no standard model for the underwater EM channel. The high conductivity of sea water, the effect of seabed and the surface make the behaviour of the channel hard to predict...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28106781/family-food-providers-perceptions-of-the-causes-of-obesity-and-effectiveness-of-weight-control-strategies-in-five-countries-in-the-asia-pacific-region-a-cross-sectional-survey
#13
Anthony Worsley, Wei Wang, Rani Sarmugam, Quynh Pham, Judhiastuty Februhartanty, Stacey Ridley
The rise of the middle classes in developing countries and the associated epidemiological transition raises the importance of assessing this population group's awareness of the causes of obesity and effective weight control strategies in order to develop effective health promotion strategies. The study aimed to examine the perceptions of the causes of obesity and weight control strategies held by middle class household food providers in Melbourne, Singapore, Shanghai, Indonesia and Vietnam. An online survey was conducted in late 2013, early 2014 among 3945 respondents...
January 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28106596/competences-in-social-media-use-in-the-area-of-health-and-healthcare
#14
Pirkko Kouri, Marja-Liisa Rissanen, Patrick Weber, Hyeoun-Ae Park
In today's life, social media offer new working ways. People are increasingly expanding interactions from face-to-face meetings to online ways of communication, networking, searching, creating and sharing information, and furthermore taking care of patients/citizens via tweeting care, Facebook care, blogging care, vlogging care, infotainment care, gamification-care, infographic care, for instance. This chapter discusses the utilisation of social media in the healthcare domain including nursing education, practice and research...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106589/from-entry-to-practice-to-advanced-nurse-practitioner-the-progression-of-competencies-and-how-they-assist-in-delivery-of-ehealth-programs-for-healthy-ageing
#15
Daragh Rodger, Pamela Hussey
Most of the health issues encountered in persons of older age are the result of one or more chronic diseases. The evidence base reports that chronic diseases can be prevented or delayed by engaging in healthy behaviors. Education provides a cost effective intervention on both economic grounds in addition to delivery of optimal patient outcomes. Information and Communication Technology (ICT) increasingly is viewed as a critical utility in eHealth delivery, providing scope for expanding online education facilities for older persons...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106586/competencies-related-to-informatics-and-information-management-for-practicing-nurses-in-select-countries-in-asia
#16
Ying Wu, Yanling Wang, Meihua Ji
The advancement of information and communication technology have enabled nurses to practice more effectively, efficiently, and safely. This chapter introduces nursing informatics competency and information management competency for nurses in China (including Mainland China, Hong Kong and Taiwan), India, Japan, Korea, and Singapore. Most countries in Asia are still in the process of developing and standardizing competences that are relevant to nurses and those specialized in nursing informatics. The level and content of nursing informatics offered in entry-to-practice nursing education programs varies greatly...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28106245/a-randomized-controlled-trial-of-mediterranean-diet-and-metformin-to-prevent-age-related-diseases-in-people-with-metabolic-syndrome
#17
Patrizia Pasanisi, Giuliana Gargano, Maria Gaetana Di Mauro, Mauro Cortellini, Alice Casagrande, Anna Villarini, Eleonora Bruno, Eliana Roveda, Gabriella Saibene, Elisabetta Venturelli, Franco Berrino
PURPOSE: Age-related non-communicable chronic diseases (ArCDs) are the leading cause of mortality. The major metabolic risk factor for their development is the metabolic syndrome (MetS), defined as a clustering of risk factors of metabolic origin such as abdominal obesity, high blood pressure, dyslipidemia and high fasting glycemia. There is increasing observational and experimental evidence that improving diet and the use of metformin (a calorie-restriction mimetic drug) may modify the risk of developing MetS and ArCD...
January 20, 2017: Tumori
https://www.readbyqxmd.com/read/28106136/long-term-exposure-to-835%C3%A2-mhz-rf-emf-induces-hyperactivity-autophagy-and-demyelination-in-the-cortical-neurons-of-mice
#18
Ju Hwan Kim, Da-Hyeon Yu, Yang Hoon Huh, Eun Ho Lee, Hyung-Gun Kim, Hak Rim Kim
Radiofrequency electromagnetic field (RF-EMF) is used globally in conjunction with mobile communications. There are public concerns of the perceived deleterious biological consequences of RF-EMF exposure. This study assessed neuronal effects of RF-EMF on the cerebral cortex of the mouse brain as a proxy for cranial exposure during mobile phone use. C57BL/6 mice were exposed to 835 MHz RF-EMF at a specific absorption rate (SAR) of 4.0 W/kg for 5 hours/day during 12 weeks. The aim was to examine activation of autophagy pathway in the cerebral cortex, a brain region that is located relatively externally...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106037/a-robust-and-tuneable-mid-infrared-optical-switch-enabled-by-bulk-dirac-fermions
#19
Chunhui Zhu, Fengqiu Wang, Yafei Meng, Xiang Yuan, Faxian Xiu, Hongyu Luo, Yazhou Wang, Jianfeng Li, Xinjie Lv, Liang He, Yongbing Xu, Junfeng Liu, Chao Zhang, Yi Shi, Rong Zhang, Shining Zhu
Pulsed lasers operating in the mid-infrared (3-20 μm) are important for a wide range of applications in sensing, spectroscopy, imaging and communications. Despite recent advances with mid-infrared gain platforms, the lack of a capable pulse generation mechanism remains a significant technological challenge. Here we show that bulk Dirac fermions in molecular beam epitaxy grown crystalline Cd3As2, a three-dimensional topological Dirac semimetal, constitutes an exceptional ultrafast optical switching mechanism for the mid-infrared...
January 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28105737/the-effects-of-power-toothbrushing-on-periodontal-inflammation-in-a-canadian-nursing-home-population-a-randomized-controlled-trial
#20
S E Lavigne, M B Doupe, A M Iacopino, S Mahmud, L Elliott
OBJECTIVES: The aim of this study was to investigate whether twice-daily use of a rotating-oscillating power toothbrush (Oral-B Professional Care 1000(™) ) in nursing home (NH) residents over a 6-week period, compared to usual care (UC), would reduce periodontal inflammation. METHODS: In this repeated measures single-blinded randomized controlled trial, 59 residents of one NH in Winnipeg, Canada, were randomized to receive either twice-daily tooth brushing with a rotating-oscillating power toothbrush (PB) or UC by caregivers...
January 19, 2017: International Journal of Dental Hygiene
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