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https://www.readbyqxmd.com/read/29053981/clinical-efficacy-onset-time-and-safety-of-bright-light-therapy-in-acute-bipolar-depression-as-an-adjunctive-therapy-a-randomized-controlled-trial
#1
Tian-Hang Zhou, Wei-Min Dang, Yan-Tao Ma, Chang-Qing Hu, Ning Wang, Guo-Yi Zhang, Gang Wang, Chuan Shi, Hua Zhang, Bin Guo, Shu-Zhe Zhou, Lei Feng, Shu-Xia Geng, Yu-Zhen Tong, Guan-Wen Tang, Zhong-Kai He, Long Zhen, Xin Yu
BACKGROUND: Bright light therapy (BLT) is an effective treatment for seasonal affective disorder and non- seasonal depression. The efficacy of BLT in treating patients with bipolar disorder is still unknown. AIMS: The aim of this study is to examine the efficacy, onset time and clinical safety of BLT in treating patients with acute bipolar depression as an adjunctive therapy (trial registration at ClinicalTrials.gov: NCT02009371). METHODS: This was a multi-center, single blind, randomized clinical trial...
September 25, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29053927/safety-of-pharmacotherapy-options-for-bulimia-nervosa-and-binge-eating-disorder
#2
Nicholas T Bello, Bryn L Yeomans
Eating disorders represent a set of psychiatric illnesses with lifelong complications and high relapse rates. Individuals with eating disorders are often stigmatized and clinicians have a limited set of treatments options. Pharmacotherapy has the potential to improve long term compliance and patient commitment to treatment for eating disorders. Areas Covered: This review will examine the efficacy and safety profile of the FDA-approved medications for the treatment of bulimia nervosa (BN) and binge eating disorder (BED)...
October 20, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/29053904/a-direct-aspiration-first-pass-technique-adapt-for-acute-stroke-therapy-a-systematic-review-and-meta-analysis
#3
Benjamin Gory, Xavier Armoiry, Rotem Sivan-Hoffman, Michel Piotin, Mikael Mazighi, Bertrand Lapergue, Raphaël Blanc, Francis Turjman
BACKGROUND AND PURPOSE: ADAPT (A Direct Aspiration First Pass Technique), involving the first-line use of large-bore distal aspiration catheter, is a new strategy in the mechanical thrombectomy of acute ischemic stroke caused by large vessel occlusion. However, its impact on reperfusion rates, clinical outcomes, and complication rates is not fully examined. METHOD: We conducted a systematic review of the literature searching multiple databases for reports on thrombectomy of acute stroke with the ADAPT technique and performed meta-analyses of clinical and radiographic outcomes...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053873/exercise-for-the-prevention-of-low-back-pain-systematic-review-and-meta-analysis-of-controlled-trials
#4
Rahman Shiri, David Coggon, Kobra Falah-Hassani
The aim of this systematic review and meta-analysis was to assess the effect of exercise in population-based interventions to prevent low back pain (LBP) and associated disability. Comprehensive literature searches were conducted in multiple databases including PubMed, Embase, and Cochrane Library from their inception through June 2017. Thirteen randomized controlled trials and three non-randomized controlled trials qualified for meta-analyses. Exercise alone reduced the risk of LBP by 33% (risk ratio = 0...
October 19, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29053849/a-network-meta-analysis-comparing-effects-of-various-antidepressant-classes-on-the-digit-symbol-substitution-test-dsst-as-a-measure-of-cognitive-dysfunction-in-patients-with-major-depressive-disorder
#5
Bernhard T Baune, Mélanie Brignone, Klaus Groes Larsen
Background: Major depressive disorder (MDD) is a common condition that often includes cognitive dysfunction. A systematic literature review of studies and a network meta-analysis (NMA) were carried out to assess the relative effect of antidepressants on cognitive dysfunction in MDD. Methods: MEDLINE ®, Embase ®, Cochrane, CDSR, PsychINFO ® databases, clinical trial registries, and relevant conference abstracts were searched for randomised controlled trials (RCTs) assessing the effects of antidepressants/placebo on cognition...
October 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29053848/is-virtual-reality-ready-for-prime-time-in-the-medical-space-a-randomized-control-trial-of-pediatric-virtual-reality-for-acute-procedural-pain-management
#6
Jeffrey I Gold, Nicole E Mahrer
Objective: To conduct a randomized control trial to evaluate the feasibility and efficacy of virtual reality (VR) compared with standard of care (SOC) for reducing pain, anxiety, and improving satisfaction associated with blood draw in children ages 10-21 years. Methods: In total, 143 triads (patients, their caregiver, and the phlebotomist) were recruited in outpatient phlebotomy at a pediatric hospital and randomized to receive either VR or SOC when undergoing routine blood draw...
October 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29053645/comparison-of-peri-implant-bone-loss-between-conventional-drilling-with-irrigation-versus-low-speed-drilling-without-irrigation
#7
H Pellicer-Chover, D Peñarrocha-Oltra, A Aloy-Prosper, J- Sanchis-Gonzalez, M A Peñarrocha-Diago, M Peñarrocha-Diago
BACKGROUND: To compare the technique of high speed drilling with irrigation and low speed drilling without irrigation in order to evaluate the success rate and peri-implant bone loss at 12 months of follow-up. MATERIAL AND METHODS: A randomized, controlled, parallel-group clinical trial was carried out in patients requiring dental implants to rehabilitate their unitary edentulism. Patients were recruited from the Oral Surgery Unit of the University of Valencia (Spain) between September 2014 and August 2015...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053519/a-low-cost-simulator-for-training-in-endoscopic-assisted-transaxillary-dual-plane-breast-augmentation
#8
Chenglong Wang, Lin Chen, Dali Mu, Minqiang Xin, Jie Luan
BACKGROUND: Endoscopic-assisted transaxillary dual-plane (EATD) technique is a popular procedure for breast augmentation, especially for Chinese women. However, frustration is often expressed by plastic surgeons when first attempting EATD surgery. Simulation-based teaching is beneficial for EATD training, but it is expensive. This study presents a low-cost simulator to help plastic surgeons exercise psychomotor skills during EATD surgery. METHODS: The low-cost simulator was invented by Dr Jie Luan (the senior author) and made of some easily available materials including a mannequin, a T-shirt printed the bottom anatomical structure of the chest, the order of dissection, and the potential bleeding spot, and an elastic compression garment printed the upper anatomical structure and the cut-off position to sever the pectoralis major muscle...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053489/the-more-things-change-the-more-they-stay-the-same-a-study-to-evaluate-compliance-with-inclusion-and-assessment-of-women-and-minorities-in-randomized-controlled-trials
#9
Stacie E Geller, Abigail R Koch, Pamela Roesch, Amarette Filut, Emily Hallgren, Molly Carnes
PURPOSE: The National Institutes of Health (NIH) Revitalization Act of 1993 requires NIH-funded clinical trials to include women and minorities as participants and assess outcomes by sex and race or ethnicity. The objective of this study was to investigate current levels of compliance with these guidelines for inclusion, analysis, and reporting in NIH-funded randomized controlled trials (RCTs) and compare the results with those from 2009 and 2004, which the authors reported previously...
October 19, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29053207/dpp-4-inhibitors-moderate-the-risk-of-genitourinary-tract-infections-associated-with-sglt2-inhibitors
#10
Gian Paolo Fadini, Benedetta Maria Bonora, Mayur Sarangdhar, Mauro Rigato, Angelo Avogaro
Genito-urinary tract infections (GUTI) are the most common adverse event (AE) during therapy with sodium-glucose cotransporter 2 inhibitors (SGLT2i). We evaluated whether dipeptidyl peptidase 4 inhibitors (DPP4i) moderate the risk of GUTI during therapy with SGLT2i, using two approaches. First, we screened the literature for randomized controlled trials (RCTs) directly comparing the frequency of GUTI in patients receiving a DPP4i/SGLT2i combination therapy versus those receiving a SGLT2i only. In the 5 trials we retrieved, the pooled RR for genital tract infections (GTI) in patients on a DPP4i/SGLT2i combination therapy versus those on SGLT2i alone was 0...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29053202/treatment-satisfaction-with-itca-650-a-novel-drug-device-delivering-continuous-exenatide-versus-twice-daily-injections-of-exenatide-in-type-2-diabetics-on-metformin
#11
Robert Henry, Julio Rosenstock, John F McCarthy, Ginger Carls, Tom Alessi, John Yee, Michelle Baron
AIMS: To evaluate treatment satisfaction in patients with type 2 diabetes (T2D), not adequately controlled by metformin, randomized to ITCA 650 (continuous exenatide in osmotic mini-pump) versus twice-daily exenatide injections (Ex-BID). MATERIALS AND METHODS: The Diabetes Medication Satisfaction Tool (DM-SAT) was administered and assessments made at baseline, week 8, and week 20 in a 24 week open-label phase 2 trial. In Stage I (weeks 1-12), 155 patients, comprising the ITT population, were randomized to three groups: ITCA 650 20 μg/day, ITCA 650 40 μg/day and Ex-BID 10 μg BID...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29053029/the-evidence-on-effectiveness-of-weekly-vs-triweekly-cisplatin-concurrent-with-radiotherapy-in-locally-advanced-head-and-neck-squamous-cell-carcinoma-hnscc-a-systematic-review-and-meta-analysis
#12
Jc Kennetth Jacinto, Jayson Co, Michael Benedict Mejia, Eugenio Emmanuel Regala
OBJECTIVE: This study aims to synthesize the current available evidences on the effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in the primary and adjuvant treatment of locally advanced head and neck squamous cell carcinoma (HNSCC). METHODS: A systematic review and meta-analysis of literature were undertaken to assess the effectiveness of weekly vs triweekly schedule in primary and adjuvant treatment for HNSCC with adverse risk features...
November 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29053023/n-acetylcysteine-for-nonsuicidal-self-injurious-behavior-in-adolescents-an-open-label-pilot-study
#13
Kathryn R Cullen, Bonnie Klimes-Dougan, Melinda Westlund Schreiner, Patricia Carstedt, Nicholas Marka, Katharine Nelson, Michael J Miller, Kristina Reigstad, Ana Westervelt, Meredith Gunlicks-Stoessel, Lynn E Eberly
BACKGROUND: Nonsuicidal self-injury (NSSI) is common in adolescents and young adults, and few evidence-based treatments are available for this significant problem. N-acetylcysteine (NAC) is a widely available nutritional supplement that has been studied in some psychiatric disorders relevant to NSSI including mood and addictive disorders. This pilot study tested the use of NAC as a potential treatment for NSSI in youth. METHODS: Thirty-five female adolescents and young adults with NSSI aged 13-21 years were enrolled in this study that had an open-label, single-arm study design...
October 20, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29052964/brief-interactive-psychoeducation-for-caregivers-of-patients-with-early-phase-psychosis-in-yogyakarta-indonesia
#14
Carla R Marchira, Irwan Supriyanto, Subandi Subandi, Mary Jo D Good, Byron J Good
AIM: Brief psychoeducation for families of psychotic patients has been shown to significantly increase family members' knowledge of the disorder. This increase is associated with reductions in relapse and rehospitalization. The aim of this study was to assess the effectiveness of brief psychoeducation about schizophrenia to caregivers of patients in early phases of psychotic disorders in Yogyakarta, Indonesia. METHODS: This study was a prospective, randomized trial with 2 parallel groups...
October 20, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29052846/improvements-of-adolescent-psychopathology-after-insomnia-treatment-results-from-a-randomized-controlled-trial-over-1%C3%A2-year
#15
Eduard J de Bruin, Susan M Bögels, Frans J Oort, Anne Marie Meijer
BACKGROUND: Adolescent insomnia can be treated effectively with cognitive behavioural therapy for insomnia (CBTI). However, little is known about effects of CBTI on psychopathology in adolescents. This study aimed to investigate whether (a) CBTI improves psychopathology in Internet- (IT) and face-to-face group treatment (GT) compared to waitlist (WL), (b) improvement in psychopathology can be attributed to reduced insomnia, (c) improvement in psychopathology remains stable for up to 1 year...
October 20, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29052805/sublingual-buprenorphine-efficacy-in-renal-colic-pain-relief-a-randomized-placebo-controlled-clinical-trial
#16
Javad Mozafari, Kambiz Masoumi, Arash Forouzan, Hassan Motamed, Malehi Amal Saki, Marzieh Dezham
INTRODUCTION: This study was designed to compare the analgesic efficacy of sublingual (SL) buprenorphine and intravenous (IV) ketorolac for renal colic pain relief. METHODS: The present study was carried out as a double-blind, double-dummy randomized clinical trial in patients diagnosed with acute renal colic attending the emergency department. The study subjects were 63 patients with confirmed renal stones. The subjects were randomly divided into two groups. One group, which included 32 patients, received SL buprenorphine tablets (2 mg) with an IV placebo, and another group, including 31 patients, received ketorolac tromethamine (30 mg) with a SL placebo...
October 20, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/29052691/discontinuing-inappropriate-medication-use-in-nursing-home-residents-a-cluster-randomized-controlled-trial
#17
Hans Wouters, Jessica Scheper, Hedi Koning, Chris Brouwer, Jos W Twisk, Helene van der Meer, Froukje Boersma, Sytse U Zuidema, Katja Taxis
Background: Inappropriate prescribing is a well-known clinical problem in nursing home residents, but few interventions have focused on reducing inappropriate medication use. Objective: To examine successful discontinuation of inappropriate medication use and to improve prescribing in nursing home residents. Design: Pragmatic cluster randomized controlled trial, with clustering by elder care physicians and their wards. (ClinicalTrials.gov: NCT01876095)...
October 10, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29052663/self-management-intervention-for-adult-cancer-survivors-after-treatment-a-systematic-review-and-meta-analysis
#18
Soo Hyun Kim, Kisook Kim, Deborah K Mayer
PROBLEM IDENTIFICATION: This study aims to evaluate the effects of self-management interventions (SMIs) for cancer survivors who completed primary treatment. 
. LITERATURE SEARCH: Using PubMed, EMBASE, CINAHL®, PsycINFO®, and Cochrane Central Register of Controlled Trails (CENTRAL), the authors conducted a systematic search of randomized, controlled trials published in English from database conception through June 2016. 
. DATA EVALUATION: The meta-analysis was conducted with Cochrane Review Manager, version 5...
November 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29052662/evaluation-of-online-learning-modules-for-improving-physical-activity-counseling-skills-practices-and-knowledge-of-oncology-nurses
#19
Kristina H Karvinen, Lynda Balneaves, Kerry S Courneya, Beth Perry, Tracy Truant, Jeff Vallance
PURPOSE/OBJECTIVES: To examine the effectiveness of online learning modules for improving physical activity counseling practices among oncology nurses. 
. DESIGN: Randomized, controlled trial.
. SETTING: Online.
. SAMPLE: 54 oncology nurses.
. METHODS: Oncology nurses were randomly assigned to the learning modules group or control group. The learning modules group completed six online learning modules and quizzes focused on physical activity for cancer survivors, general physical activity principles, and motivational interviewing...
November 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29052658/feasibility-study-of-an-online-intervention-to-support-male-spouses-of-women-with-breast-cancer
#20
Wendy Duggleby, Sunita Ghosh, Kelly Struthers-Montford, Cheryl Nekolaichuk, Ceinwen Cumming, Roanne Thomas, Katia Tonkin, Jennifer Swindle
PURPOSE/OBJECTIVES: To evaluate the feasibility of a web-based psychosocial supportive intervention entitled Male Transition Toolkit (MaTT). 
. DESIGN: Randomized, controlled trial, mixed methods, concurrent feasibility design.
. SETTING: Edmonton, a large metropolitan city in western Canada.
. SAMPLE: 40 dyads (women with breast cancer and their spouse).
. METHODS: Male spouse participants in the treatment group accessed MaTT for four weeks...
November 1, 2017: Oncology Nursing Forum
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