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https://www.readbyqxmd.com/read/29925099/a-systematic-review-on-promoting-adherence-to-antiretroviral-therapy-in-hiv-infected-patients-using-mobile-phone-technology
#1
Yuri Quintana, Eduardo A Gonzalez Martorell, Darren Fahy, Charles Safran
OBJECTIVE:  Adherence to antiretroviral therapy (ART) is paramount to successful long-term suppression of human immunodeficiency virus (HIV). For poorly adherent patients with HIV, barriers to remaining adherent may be overcome by the implementation of targeted interventions delivered via mobile devices. This systematic review is focused specifically on mobile phone technologies to deliver adherence interventions in HIV/acquired immunodeficiency syndrome (AIDS) populations. METHODS:  This review (PROSPERO #CRD42017065131) systematically extracted data from published literature from five databases on mobile phone interventions to improve adherence to ART for HIV...
April 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29925090/erratum-to-a-double-blind-randomized-placebo-controlled-trial-of-17-alpha-hydroxyprogesterone-caproate-in-the-management-of-preterm-premature-rupture-of-membranes
#2
Elizabeth S Langen, Anita Sit, Katie Sherwin, Deirdre J Lyell, Yair J Blumenfeld, Yasser Y El-Sayed
No abstract text is available yet for this article.
June 20, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29925066/the-vasopressin-system-in-the-risk-of-diabetes-and-cardiorenal-disease-and-hydration-as-a-potential-lifestyle-intervention
#3
Sofia Enhörning, Olle Melander
BACKGROUND: Type 2 diabetes, chronic kidney disease (CKD) and its cardiovascular complications are increasing as health problems worldwide. These diseases are interrelated with overlapping occurrence and once diabetes is established, the risk of cardiorenal disease is dramatically elevated. Thus, a search for unifying modifiable risk factors is key for effective prevention. SUMMARY: Elevated fasting plasma concentration of vasopressin, measured with the marker copeptin, predicts new onset type 2 diabetes as well as renal function decline...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29924907/tamoxifen-and-meglumine-antimoniate-combined-therapy-in-cutaneous-leishmaniasis-patients-a-randomized-trial
#4
Paulo R L Machado, Camila S Ribeiro, Jaqueline França-Costa, Mayra E F Dourado, Cristiana T Trinconi, Jenicer K U Yokoyama-Yasunaka, Hayna Malta-Santos, Valéria M Borges, Edgar M Carvalho, Silvia R B Uliana
OBJECTIVES: There is a clear need for new strategies of leishmaniasis treatment. This work was conducted to evaluate the efficacy of the co-administration of tamoxifen and meglumine antimoniate (SbV ) in a phase II pilot clinical trial in localized cutaneous leishmaniasis patients. METHODS: A randomized controlled pilot clinical trial was conducted to evaluate the efficacy and safety of oral (40 mg/day for 20 days) or topical tamoxifen (0.1% tamoxifen citrate for 20 days) combined with meglumine antimoniate (20 mg SbV /kg/day for 20 days) versus a standard SbV protocol (20 mg/kg/day for 20 days) for the treatment of cutaneous leishmaniasis...
June 20, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29924719/functional-and-patient-reported-outcomes-improve-over-the-course-of-rehabilitation-a-secondary-analysis-of-the-acl-sports-trial
#5
Amelia J H Arundale, Jacob J Capin, Ryan Zarzycki, Angela Smith, Lynn Snyder-Mackler
BACKGROUND: The Anterior Cruciate Ligament-Specialized Post-Operative Return to Sports (ACL-SPORTS) randomized controlled trial was designed to address deficits in functional and patient-reported outcomes. The trial examined the effects of a secondary ACL prevention program that included progressive strengthening, agility training, plyometrics (SAP), and other components of current primary prevention protocols, with perturbation training (SAP + PERT group) and without PERT (SAP group)...
June 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29924704/effects-of-surgery-with-salvage-stereotactic-radiosurgery-versus-surgery-with-whole-brain-radiation-therapy-in-patients-with-one-to-four-brain-metastases-jcog0504-a-phase-iii-noninferiority-randomized-controlled-trial
#6
Takamasa Kayama, Shinya Sato, Kaori Sakurada, Junki Mizusawa, Ryo Nishikawa, Yoshitaka Narita, Minako Sumi, Yasuji Miyakita, Toshihiro Kumabe, Yukihiko Sonoda, Yoshiki Arakawa, Susumu Miyamoto, Takaaki Beppu, Kazuhiko Sugiyama, Hirohiko Nakamura, Motoo Nagane, Yoko Nakasu, Naoya Hashimoto, Mizuhiko Terasaki, Akira Matsumura, Eiichi Ishikawa, Toshihiko Wakabayashi, Yasuo Iwadate, Shiro Ohue, Hiroyuki Kobayashi, Manabu Kinoshita, Kenichiro Asano, Akitake Mukasa, Katsuyuki Tanaka, Akio Asai, Hideo Nakamura, Tatsuya Abe, Yoshihiro Muragaki, Koichi Iwasaki, Tomokazu Aoki, Takao Watanabe, Hikaru Sasaki, Shuichi Izumoto, Masahiro Mizoguchi, Takayuki Matsuo, Hideo Takeshima, Motohiro Hayashi, Hidefumi Jokura, Takashi Mizowaki, Eiji Shimizu, Hiroki Shirato, Masao Tago, Hiroshi Katayama, Haruhiko Fukuda, Soichiro Shibui
Purpose Whereas whole-brain radiotherapy (WBRT) has been the standard treatment of brain metastases (BMs), stereotactic radiosurgery (SRS) is increasingly preferred to avoid cognitive dysfunction; however, it has not been clearly determined whether treatment with SRS is as effective as that with WBRT or WBRT plus SRS. We thus assessed the noninferiority of salvage SRS to WBRT in patients with BMs. Patients and Methods Patients age 20 to 79 years old with performance status scores of 0 to 2-and 3 if caused only by neurologic deficits-and with four or fewer surgically resected BMs with only one lesion > 3 cm in diameter were eligible...
June 20, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29924703/markers-of-renal-function-in-older-adults-completing-a-higher-protein-obesity-intervention-and-one-year-later-findings-from-the-measur-up-trial
#7
Kathryn N Porter Starr, Shelley R McDonald, Aubrey Jarman, Melissa Orenduff, Richard Sloane, Carl F Pieper, Connie W Bales
Increases in rates of obesity in the older population are hastening the development of chronic illnesses, including chronic kidney disease (CKD). However, obesity reduction in older adults is besought with concerns about the long-term benefit/risk, especially regarding loss of muscle mass and its impact on function. Higher protein intakes have been advocated to help offset the tendency for loss of muscle during weight reduction but this raises concerns about possible negative effects on older kidneys. We assessed markers of renal function in venous blood samples collected during a six-month randomized controlled weight loss trial of higher protein intake in obese (n = 67; BMI ≥ 30 kg/m2 ) older (≥60 years) adults with physical frailty and age-normal renal status (glomerular filtration rate [GFR] ≥ 45); the Control diet (0...
June 20, 2018: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29924641/efficacy-safety-and-acceptability-of-the-new-pen-needle-34g-%C3%A3-3-5-mm-a-cross-over-randomized-non-inferiority-trial-ago-02-study
#8
Giorgia De Berardis, Marco Scardapane, Giuseppe Lucisano, Santina Abbruzzese, Antonio Carlo Bossi, Elisa Cipponeri, Paola D'Angelo, Lucia Fontana, Roberta Lancione, Giuseppe Marelli, Luigi Sciangula, Antonio Nicolucci
OBJECTIVE: Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin. METHODS: This is an open, randomized, two-period cross-over, noninferiority trial. Every treatment period lasted 3 weeks...
June 20, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29924506/clinical-predictors-of-extrapyramidal-symptoms-associated-with-aripiprazole-augmentation-for-the-treatment-of-late-life-depression-in-a-randomized-controlled-trial
#9
Jonathan H Hsu, Benoit H Mulsant, Eric J Lenze, Marcos Sanches, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger
OBJECTIVE: Augmentation with aripiprazole is an effective pharmacotherapy for treatment-resistant late-life depression (LLD). However, aripiprazole can cause extrapyramidal symptoms (EPS) such as akathisia and parkinsonism; these symptoms are distressing and can contribute to treatment discontinuation. We investigated the clinical trajectories and predictors of akathisia and parkinsonism in older patients receiving aripiprazole augmentation for treatment-resistant LLD. METHODS: Between 2009 and 2013, depressed older adults who did not remit with venlafaxine were randomized to aripiprazole or placebo in a 12-week trial...
June 19, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29924421/description-and-preliminary-outcomes-of-an-in-vivo-exposure-group-treatment-for-posttraumatic-stress-disorder
#10
Eliora Porter, Erin G Romero, Melissa D Barone
Prolonged exposure (PE) therapy is traditionally delivered individually to patients. To engage more veterans in care, an in vivo exposure group treatment was developed in an urban VA medical center. This treatment represented a modification of the in vivo exposure portion of PE, with the addition of in-session, therapist-assisted in vivo exposures. Here, we describe this 12-week treatment and present preliminary outcome data. Demographics and pre- and posttreatment scores on the PTSD Checklist-Specific (PCL-S) and Beck Depression Inventory-II (BDI-II) were extracted from a program evaluation database...
June 20, 2018: Journal of Traumatic Stress
https://www.readbyqxmd.com/read/29924393/what-happens-to-nutrition-intake-in-the-post-intensive-care-unit-hospitalization-period-an-observational-cohort-study-in-critically-ill-adults
#11
Emma J Ridley, Rachael L Parke, Andrew R Davies, Michael Bailey, Carol Hodgson, Adam M Deane, Shay McGuinness, D James Cooper
BACKGROUND: Little is currently known about nutrition intake and energy requirements in the post-intensive care unit (ICU) hospitalization period in critically ill patients. We aimed to describe energy and protein intake, and determine the feasibility of measuring energy expenditure during the post-ICU hospitalization period in critically ill adults. METHODS: This is a nested cohort study within a randomized controlled trial in critically ill patients. After discharge from ICU, energy and protein intake was quantified periodically and indirect calorimetry attempted...
June 20, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29924388/fat-supplementation-of-human-milk-for-promoting-growth-in-preterm-infants
#12
REVIEW
Emma A Amissah, Julie Brown, Jane E Harding
BACKGROUND: As preterm infants do not experience the nutrient accretion and rapid growth phase of the third trimester of pregnancy, they are vulnerable to postnatal nutritional deficits, including of fat. Consequently, they require higher fat intakes compared to their full term counterparts to achieve adequate growth and development. Human milk fat provides the major energy needs of the preterm infant and also contributes to several metabolic and physiological functions. Although human milk has many benefits for this population, its fat content is highly variable and may be inadequate for their optimum growth and development...
June 19, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29924221/tazarotene-gel-with-narrow-band-uvb-phototherapy-a-synergistic-combination-in-psoriasis
#13
Surabhi Dayal, Rajiv Kaura, Priyadarshini Sahu, Vijay Kumar Jain
BACKGROUND: Narrow-band UVB (NB-UVB) has been shown to be one of the most effective treatment modalities for psoriasis. Tazarotene, a known effective anti-psoriatic modality, when combined with NB-UVB may enhance the therapeutic success. OBJECTIVE: To study clinical efficacy and safety of combination of NB-UVB with topical tazarotene 0.05% gel in psoriasis. METHOD: Thirty patients with plaque psoriasis having symmetrical lesions were enrolled for 12 weeks...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924184/the-influence-of-inspiratory-muscle-training-combined-with-the-pilates-method-on-lung-function-in-elderly-women-a-randomized-controlled-trial
#14
Guilherme Medeiros de Alvarenga, Simone Arando Charkovski, Larissa Kelin Dos Santos, Mayara Alves Barbosa da Silva, Guilherme Oliveira Tomaz, Humberto Remigio Gamba
OBJECTIVE: Aging is progressive, and its effects on the respiratory system include changes in the composition of the connective tissues of the lung that influence thoracic and lung compliance. The Powerbreathe® K5 is a device used for inspiratory muscle training with resistance adapted to the level of the inspiratory muscles to be trained. The Pilates method promotes muscle rebalancing exercises that emphasize the powerhouse. The aim of this study was to evaluate the influence of inspiratory muscle training combined with the Pilates method on lung function in elderly women...
2018: Clinics
https://www.readbyqxmd.com/read/29924167/stress-of-nursing-students-in-clinical-simulation-a-randomized-clinical-trial
#15
Radamés Boostel, Jorge Vinícius Cestari Felix, Carina Bortolato-Major, Edivane Pedrolo, Stela Adami Vayego, Maria de Fátima Mantovani
OBJECTIVE: To evaluate and compare the perception of stressors by nursing students before and after a high-fidelity clinical simulation or conventional laboratory practice class. METHOD: This is a randomized clinical trial conducted with 52 nursing students. Both groups had theoretical classes about cardiothoracic physical examination, followed by practice class in skill laboratory. In addition, the experimental group took part in a high-fidelity simulation scenario...
May 2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29924042/transcutaneous-electric-nerve-stimulation-over-acupoints-for-chronic-obstructive-pulmonary-disease-protocol-for-a-systematic-review-and-meta-analysis
#16
Jia-Jia Wang, Yang Xie, Hu-Lei Zhao, Wei-Hong Han, Xiao-Chun Wang
BACKGROUND: There is a limited evidence concerning the efficacy of transcutaneous electric nerve stimulation over acupoints (Acu-TENS) for chronic obstructive pulmonary disease (COPD). Thus, this review aims to systematically determine the effect of Acu-TENS on COPD. METHODS: PubMed, Embase, The Cochrane Library, Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chongqing VIP, and Wanfang Data will be searched from their inception to May 10, 2018...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924041/safety-and-efficacy-of-galgeun-tang-ga-cheongung-sinyi-a-herbal-formula-for-the-treatment-of-chronic-rhinosinusitis-a-study-protocol-for-a-randomized-controlled-trial
#17
Mi Ju Son, Ojin Kwon, Sungha Kim, Young-Eun Kim, So Young Jung, Bo-Young Kim, Jeong In Kang, Jun-Hwan Lee, Dong-Hyo Lee
INTRODUCTION: A herbal formula, Galgeun-tang-ga-cheongung-sinyi (GGTCS), is traditionally used for the treatment of rhinosinusitis in East Asian countries. However, there is a dearth of clinical evidence supporting the effects of this medication. Here, we describe the protocol for a randomized controlled study designed to investigate the efficacy and safety of GGTCS for the treatment of chronic rhinosinusitis (CRS). METHODS AND ANALYSIS: To investigate the clinical efficacy and safety of GGTCS for the treatment of CRS, a randomized, double-blind, placebo-controlled, parallel group, clinical trial has been designed...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924040/posterior-paraspinal-muscle-versus-post-middle-approach-for-the-treatment-of-thoracolumbar-burst-fractures-a-randomized-controlled-trial
#18
Wenli Chang, Dianling Zhang, Wei Liu, Xiaodong Lian, Zhenqing Jiao, Wei Chen
BACKGROUND: This randomized controlled trial (RCT) aimed to compare the clinical outcomes of thoracolumbar burst fractures (TLBFs) treated with open reduction and internal fixation via the posterior paraspinal muscle approach (PPMA) and the post-middle approach (PA). METHODS: Patients with a traumatic single-level TLBFs (T10-L2), treated at our hospital between December 2009 and December 2014, were randomly allocated to Group A (PPMA) and Group B (PA). Sex, age, time from injury to surgery, the American Spinal Injury Association Impairment Scale score (ASIAIS), comorbidities, vertebral level, pre- and postoperative kyphotic angle (KA), visual analog scale (VAS) pain score, and the Oswestry Disability Index (ODI) scores were included in the analysis...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924029/a-low-cost-kinect-based-virtual-rehabilitation-system-for-inpatient-rehabilitation-of-the-upper-limb-in-patients-with-subacute-stroke-a-randomized-double-blind-sham-controlled-pilot-trial
#19
Won-Seok Kim, Sungmin Cho, Seo Hyun Park, Ji-Young Lee, SuYeon Kwon, Nam-Jong Paik
BACKGROUND: We designed this study to prove the efficacy of the low-cost Kinect-based virtual rehabilitation (VR) system for upper limb recovery among patients with subacute stroke. METHODS: A double-blind, randomized, sham-controlled trial was performed. A total of 23 subjects with subacute stroke (<3 months) were allocated to sham (n = 11) and real VR group (n = 12). Both groups participated in a daily 30-minute occupational therapy for upper limb recovery for 10 consecutive weekdays...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29924011/clinical-inertia-in-the-pharmacological-management-of-hypertension-a-systematic-review-and-meta-analysis
#20
Tal Milman, Raed A Joundi, Naif M Alotaibi, Gustavo Saposnik
BACKGROUND: Clinical Inertia is defined as "failure of health care providers to initiate or intensify therapy according to current guidelines". This phenomenon is gaining increasing attention as a major cause of clinicians' failure to adequately manage hypertension, thus leading to an increased incidence of cardiovascular events. We performed a systematic review and meta-analysis of randomized controlled trials to determine whether interventions aimed at reducing clinical inertia in the pharmacological treatment of hypertension improve blood pressure (BP) control...
June 2018: Medicine (Baltimore)
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