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https://www.readbyqxmd.com/read/29236297/mri-change-metrics-of-facioscapulohumeral-muscular-dystrophy-stir-and-t1
#1
Mark R Ferguson, Sandra L Poliachik, Christopher B Budech, Nancy E Gove, Gregory T Carter, Leo H Wang, Daniel G Miller, Dennis W W Shaw, Seth D Friedman
INTRODUCTION: MRI evaluation in facioscapulohumeral muscular dystrophy (FSHD) demonstrates fatty replacement and inflammation/edema in muscle. Our previous work demonstrated Short T1 Inversion Recovery (STIR)-hyperintense (STIR+) signal in muscle 2 years prior to fatty replacement. We evaluated leg muscle STIR changes and fatty replacement within 14 months. METHODS: FSHD subjects received 2 MRI scans of thigh and calf over a 6.9-13.8 month interval. Quality of life measures were collected...
December 13, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/29230289/accessory-anterolateral-talar-facet-impingement-with-tibialis-spastic-varus-foot
#2
Toshinori Kurashige
In recent years, some authors have reported accessory anterolateral talar facet impingement with flatfoot including peroneal spastic flatfoot. Conversely, to our knowledge, no case report has been published about accessory anterolateral talar facet impingement with tibialis spastic varus foot. We report the first case in a 22-year-old man with intellectual disability, bilateral cleft hands and type 1 diabetes mellitus. Since spraining his left ankle over a year earlier, he experienced left sinus tarsi pain while standing and walking...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29228525/sleep-apnea-and-idiopathic-leg-edema-a-case-control-study
#3
Reza Shahmirzai, Mohammadreza Firouzifar
Idiopathic leg edema is subject to a lot of debates among physicians. Recently sleep apnea was stated to be the cause. We sought to investigate this matter in a sample of Iranian patients with idiopathic leg edema. In this case-control study, 110 patients were selected based on our inclusion/exclusion criteria and allocated to the case (with idiopathic edema, n=55) and control (without edema, n=55) groups. Sex, age, weight, height, and body mass index (BMI) of all subjects were recorded. We evaluated daytime somnolence of all patients using Epworth sleepiness scale and then calculated Apnea, hypopnea index (AHI) using ResMed ApneaLink and AHI≥15 were considered as sleep apnea...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29228410/clinical-course-of-eosinophilic-cellulitis
#4
Hideki Ozawa, Kousuke Kuwano, Saki Manabe, Toru Ishihara, Masamichi Komatsu, Takako Kobayashi, Hidetaka Yanagi, Masayuki Oki, Atsushi Takagi
The patient was a previously healthy 23-year-old woman who made an outpatient visit to our hospital's Department of General Internal Medicine after developing pain and edema of the lower legs a week earlier. The patient was diagnosed with eosinophilic cellulitis (EC) based on an increased eosinophil count of 5,418/mm3 and the results of a skin biopsy of the lower leg that showed eosinophilic infiltration of the dermal tissue. Her condition improved after oral prednisone therapy. EC presents clinically as edema and eosinophilia...
December 20, 2017: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/29225270/iga-vasculitis-with-simultaneous-cardiopulmonary-involvement-a-case-report
#5
Kazunori Bando, Hirofumi Maeba, Ichiro Shiojima
A 60-year-old man with a history of hypertension, type 2 diabetes, and reflux esophagitis was admitted to our hospital with hemoptysis, dyspnea, and leg edema. We diagnosed him with adult IgA vasculitis based on the presence of purpura, elevated serum IgA fibronectin complexes, pathophysiological findings, a skin biopsy showing leukocytoclastic vasculitis, and immunofluorescence studies demonstrating granular IgA and C3 deposits in the blood vessel wall. He showed concurrent cardiopulmonary involvement without involvement of the gastrointestinal system and kidneys, which are commonly affected in IgA vasculitis patients...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29195497/bilateral-uveitis-and-macular-edema-induced-by-nivolumab-a-case-report
#6
Claire Theillac, Morgane Straub, Anne-Laure Breton, Luc Thomas, Stéphane Dalle
BACKGROUND: Nivolumab is a fully human antibody which is routinely used at first therapy for metastatic melanoma. Usually, side effects are immune-related adverse events. We report a case of a man who developed bilateral anterior uveitis and macular serous retinal detachment during nivolumab treatment for metastatic melanoma. CASE PRESENTATION: A man on nivolumab treatment for a leg melanoma with duodenal and lymph nodes metastases developed a sudden bilateral visual acuity impairment and bilateral non-painfull redness eyes several days after the third infusion...
December 1, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/29181824/ages-rage-overexpression-in-a-patient-with-smoking-related-idiopathic-nodular-glomerulosclerosis
#7
Nao Nakamura, Kensei Taguchi, Yoshihiro Miyazono, Keiichiro Uemura, Kiyomi Koike, Yuka Kurokawa, Yosuke Nakayama, Yusuke Kaida, Ryo Shibata, Akihiro Tsuchimoto, Katsuhiko Asanuma, Kei Fukami
We report a case of smoking-related idiopathic nodular glomerulosclerosis (ING) with overexpression of glomerular advanced glycation end products (AGEs) and their receptor (RAGE). A 59-year-old Japanese man with nephrotic syndrome, who had a smoking history of one pack of cigarettes per day for approximately 40 years, presented with a 3-year history of urinalysis abnormalities without clinical evidence of diabetic mellitus. The patient's leg edema progressively worsened over the previous 2 years, and he was admitted to our hospital...
November 27, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29179990/snakebite-by-micrurus-averyi-schmidt-1939-in-the-brazilian-amazon-basin-case-report-coral-snakebite-by-micrurus-averyi
#8
REVIEW
Iran Mendonça da Silva, Jorge Contreras Bernal, Pedro Ferreira Gonçalves Bisneto, Antônio Magela Tavares, Valéria Mourão de Moura, Claudio S Monteiro-Junior, Rima Raad, Paulo Sergio Bernarde, Jacqueline de Almeida Gonçalves Sachett, Wuelton Marcelo Monteiro
Micrurus snakes, commonly known as coral snakes, are responsible for 0.4% of the snakebites envenomings in Brazil. In this report, we describe a case of envenoming by Micrurus averyi, the black-headed coral snake, recorded in the western Brazilian Amazon. To the best of our knowledge, this is the first published case perpetrated by this species. The major complaint of the patient was an intense local pain and paresthesia. Examination of the bite site revealed edema extending from the left foot up the left leg that was accompanied by erythema involving the foot and distal third of the leg...
November 24, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29166135/application-of-diffusion-tensor-imaging-in-quantitatively-monitoring-chronic-constriction-injury-of-rabbit-sciatic-nerves-correlation-with-histological-and-functional-changes
#9
Wenjun Wu, Yanfeng Niu, Xiangquan Kong, Dingxi Liu, Xi Long, Shenglei Shu, Xiaoyun Su, Bing Wang, Xiaoming Liu, Yamei Ma, Lixia Wang
OBJECTIVE: To investigate the potential of diffusion tensor imaging (DTI) in quantitatively monitoring chronic constriction injuries (CCI) of sciatic nerves and to analyze the association of DTI parameters with nerve histology and limb function. METHODS: CCI was created on sciatic nerves in the right hind legs of 20 rabbits with the left as control. DTI parameters -- fractional anisotropy (FA), apparent diffusion coefficient (ADC), axial diffusivity (AD) and radial diffusivity (RD) -- and limb function were longitudinally evaluated...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29145269/multimodal-ultrasonographic-assessment-of-leiomyosarcoma-of-the-femoral-vein-in-a-patient-misdiagnosed-as-having-deep-vein-thrombosis-a-case-report
#10
Mei Zhang, Feng Yan, Bin Huang, Zhoupeng Wu, Xiaorong Wen
RATIONALE: Primary leiomyosarcoma (LMS) of the vein is a rare tumor that arises from the smooth muscle cells of the vessel wall and has an extremely poor prognosis. This tumor can occur in vessels such as the inferior vena cava, great saphenous vein, femoral vein, iliac vein, popliteal vein, and renal vein; the inferior vena cava is the most common site. LMS of the femoral vein can result in edema and pain in the lower extremity; therefore, it is not easy to be differentiated from deep vein thrombosis (DVT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29098102/compression-of-the-femoral-vessels-by-a-pseudotumor-after-metal-on-metal-total-hip-arthroplasty
#11
Yasuaki Tamaki, Tomohiro Goto, Takahiko Tsutsui, Tomoya Takasago, Keizo Wada, Koichi Sairyo
Here we present a case of pseudotumor following total hip arthroplasty (THA) that resulted in a circulatory disturbance caused by compression of the femoral vasculature. A 63-year-old man presented with pain, swelling, and redness of the left leg 5 years after primary metal-on-metal THA using the AML-Plus stem, Pinnacle® acetabular cup, and 36 mm diameter Ultamet™ metal head system (DePuy Orthopaedics, Warsaw, IN). Enhanced computed tomography and magnetic resonance imaging revealed a large cystic lesion extending from the left hip anteriorly to the intrapelvic region and compressing the left femoral vessels...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29097175/characteristics-of-patients-and-patterns-of-chronic-venous-disease-of-the-lower-limbs-in-a-referral-hospital-in-cameroon
#12
Marcus Fokou, Boniface Moifo, Emmanuel Fongang, Abel Teyang, Wallinjon Muna
OBJECTIVE: The objective of this study was to investigate the magnitude of chronic venous disease (CVD) in sub-Saharan Africa, specifically the characteristics of the patients, the symptoms, the signs, and the severity. METHODS: From December 2013 to December 2016, a cross-sectional study was conducted of all consecutive patients with CVD aged ≥18 years and attending the outpatient clinic of the Yaoundé General Hospital in Cameroon. We recorded information on demographics, relevant medical history, symptoms, lifestyle, and clinical presentation...
October 30, 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29090455/furuncular-myiasis-for-the-western-dermatologist-treatment-in-outpatient-consultation
#13
Romain Blaizot, Christophe Vanhecke, Philippe Le Gall, Alexandre Duvignaud, Marie-Catherine Receveur, Denis Malvy
BACKGROUND: Furuncular myiasis is likely to be seen by Western dermatologists because of the increasing number of international travelers but remains unfamiliar to most of them, who tend to refer these patients to hospitals. Different treatments have been proposed, but many of them are not achievable in outpatient consultation. METHODS: We reported three typical cases of furuncular myiasis, according to each species involved, and proposed diagnostic and therapeutic guidelines for dermatologists in outpatient consultation...
October 31, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29077601/live-threatening-autoimmune-cardiomyopathy-reproducibly-induced-in-a-patient-by-checkpoint-inhibitor-therapy
#14
Azadeh Tajmir-Riahi, Tanja Bergmann, Michael Schmid, Abbas Agaimy, Gerold Schuler, Lucie Heinzerling
Checkpoint inhibitors induce a plethora of immune-related adverse events (irAEs) including autoimmune colitis, hepatitis, endocrinopathies, and rarer side effects like neuritis. Here, a case of autoimmune cardiomyopathy (grade 3 CTCAE) and myocarditis under combination therapy with nivolumab plus ipilimumab in a 72-year-old melanoma patient is reported. Treatment induced a partial response for 14 months. However, after 10 infusions the patient developed dyspnea, edema of the legs, ascites and a weight gain of 10 kg because of a decompensated heart insufficiency with a reduced ejection fraction from formerly 48%-50% to 15%...
October 26, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29068987/membranous-nephropathy-in-a-patient-with-ankylosing-spondylitis-a-case-report
#15
Ruiying Chen, Fang Li, Qionghong Xie, Jun Xue, Lingyun Lai, Shaojun Liu, Liyin Zhang, Chuanming Hao
RATIONALE: Renal complications in ankylosing spondylitis (AS) were rarely observed, and proteinuria associated with AS can be seen often due to amyloidosis in this kind of complications, while membranous nephropathy (MN) is seldom considered. This article reports a case of coexistence of AS and MN, to provide the exact relationship of these 2 entities and recognized some causes of renal involvement in AS. PATIENT CONCERNS: A 44-year-old female presented with pain of the left leg for 4 years and pedal edema for 2 weeks...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049234/case-report-features-of-hand-foot-and-mouth-disease-in-neonates
#16
Wen-Wen Chen, Zhao-Bin Yang, Lian-Shu Lian, Li-Ping Xu
RATIONALE: Hand, foot and mouth disease (HFMD) is caused by enterovirus. The virus may exist in secretions. PATIENT CONCERNS: Five neonates had symptoms of fever and maculopapular rashes involving face, trunk, breech, arms, and legs, especially scattering on palms and feet. Blood, oropharyngeal fluid, urine, and cerebrospinal fluid (CSF) samples were collected and detected for further diagnoses with the consent of the infants' parents. Some of them suffered aseptic meningitis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29047318/spontaneous-spinal-epidural-hemorrhage-following-disseminated-intravascular-coagulation-resulting-in-paraplegia-a-case-report
#17
Nazia Dildar, Saeed Bin Ayaz, Muhammad Omer Aamir, Nadeem Ahmad
CONTEXT: Spontaneous spinal epidural hemorrhage (SSEH) mostly presents as low back pain with or without a radiculopathy, and rarely with paraplegia or tetraplegia depending on the site and severity of spinal cord compression. We present here a case who had anemia and developed paraplegia following disseminated intravascular coagulation (DIC) due to a transfusion reaction. FINDINGS: A 65-year-old lady presented with sudden onset chest pain radiating to nape of the neck followed by loss of sensations and power in legs few hours after a blood transfusion...
October 19, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29036258/serpiginous-purpuric-eruption-of-the-leg
#18
Kristin Totoraitis, Cynthia M Magro, Adam Friedman
A previously healthy 68-year-old male presented with a rash on his right lower leg. The lesions had spread along the leg since onset 9 days prior, and the patient reported localized soreness and pruritus. He denied systemic symptoms including fever, fatigue, myalgia, joint pain, and recent illness. Physical examination revealed a serpiginous, purpuric eruption on the anterior and posterior right thigh and lower leg. A 4mm punch biopsy from the right lower leg revealed a Th2 dominant process reflective of a type IV delayed hypersensitivity reaction...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29034036/intervention-for-varicose-veins-of-lower-extremities-lowers-the-brain-natriuretic-peptide-values-in-varicose-vein-patients
#19
Kiyoshi Tamura
Objective: To evaluate the relationship between varicose veins and heart failure, both of which cause edema of lower extremities. Materials and Methods: We enrolled 150 patients who underwent intervention for varicose veins of lower extremities between December 2012 and October 2015, and perioperative data were retrospectively investigated. Results: Of the 150 patients, 104 (69.3%) were females. The mean age was 66.8±10.6 years (27-85 years). Eighty (53.3%) patients had varicose veins in both legs. In all patients, the postoperative (brain natriuretic peptide (BNP) value was significantly lower than the preoperative BNP value (pre : post=39...
June 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/28979852/benefits-of-ilizarov-automated-bone-distraction-for-nerves-and-articular-cartilage-in-experimental-leg-lengthening
#20
Nathalia Shchudlo, Tatyana Varsegova, Tatyana Stupina, Michael Shchudlo, Marat Saifutdinov, Andrey Yemanov
AIM: To determine peculiarities of tissue responses to manual and automated Ilizarov bone distraction in nerves and articular cartilage. METHODS: Twenty-nine dogs were divided in two experimental groups: Group M - leg lengthening with manual distraction (1 mm/d in 4 steps), Group A - automated distraction (1 mm/d in 60 steps) and intact group. Animals were euthanized at the end of distraction, at 30(th) day of fixation in apparatus and 30 d after the fixator removal...
September 18, 2017: World Journal of Orthopedics
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