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https://www.readbyqxmd.com/read/28719551/annulus-fibrosus-repair-using-high-density-collagen-gel-an-in-vivo-ovine-model
#1
Brenton Pennicooke, Ibrahim Hussain, Connor Berlin, Stephen R Sloan, Brandon Borde, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez, Jonathan Cheetham, Lawrence J Bonassar, Roger Härtl
STUDY DESIGN: Ovine in vivo study. OBJECTIVE: To perform lateral approach lumbar surgery in an ovine model to administer an injectable riboflavin (RF) cross-linked high-density collagen (HDC) gel and to assess its ability to mitigate intervertebral disc (IVD) degeneration after induced annulus fibrosus (AF) injury. SUMMARY OF BACKGROUND DATA: Biological-based injectable gels have shown efficacy in restoring biomechanical, radiographic, and histological parameters in IVD-injured animal models...
July 17, 2017: Spine
https://www.readbyqxmd.com/read/28717905/analysis-of-injury-and-mortality-patterns-in-deceased-patients-with-road-traffic-injuries-an-autopsy-study
#2
Roman Pfeifer, Sylvia Schick, Christopher Holzmann, Matthias Graw, Michel Teuben, Hans-Christoph Pape
BACKGROUND: Despite improvements in prevention and rescue, mortality rates after severe blunt trauma continue to be a problem. The present study analyses mortality patterns in a representative blunt trauma population, specifically the influence of demographic, injury pattern, location and timing of death. METHODS: Patients that died between 1 January 2004 and 31 December 2005 were subjected to a standardised autopsy. INCLUSION CRITERIA: death from blunt trauma due to road traffic injuries (Injury Severity Score ≥ 16), patients from a defined geographical area and death on scene or in hospital...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28716705/pathobiology-of-biliary-epithelia
#3
REVIEW
Angela C Cheung, Maria J Lorenzo Pisarello, Nicholas F LaRusso
Cholangiocytes are epithelial cells that line the intra- and extrahepatic biliary tree. They serve predominantly to mediate the content of luminal biliary fluid, which is controlled via numerous signaling pathways influenced by endogenous (e.g., bile acids, nucleotides, hormones, neurotransmitters etc.) and exogenous (microbes/microbial products, drugs etc.) molecules. When injured, cholangiocytes undergo apoptosis/lysis, repair and proliferation. They also become senescent, a form of cell cycle arrest, which may prevent propagation of injury and/or malignant transformation...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28716590/lumbar-muscle-inflammation-alters-spinally-mediated-locomotor-recovery-induced-by-training-in-a-mouse-model-of-complete-spinal-cord-injury
#4
Renaud Jeffrey-Gauthier, Mathieu Piché, Hugues Leblond
Locomotor networks after spinal cord injury (SCI) are shaped by training-activated proprioceptive and cutaneous inputs. Nociception from injured tissues may alter these changes but has largely been overlooked. The objective of the present study was to ascertain whether lumbar muscle inflammation hinders locomotion recovery in a mouse model of complete SCI. Lower limb kinematics during treadmill training was assessed before and after complete SCI at T8 (2, 7, 14, 21 and 28 days post-injury). Locomotor recovery was compared in 4 groups of CD1 mice: control spinal mice; spinal mice with daily locomotor training; spinal mice with lumbar muscle inflammation (Complete Freund's Adjuvant (CFA) injection); and spinal mice with locomotor training and CFA...
July 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28714893/loneliness-insomnia-and-suicidal-behavior-among-school-going-adolescents-in-western-pacific-island-countries-role-of-violence-and-injury
#5
Bimala Sharma, Tae Ho Lee, Eun Woo Nam
This study aimed to examine whether being bullied, fighting, and injury, regarded in terms of frequency and nature, were significantly associated with psychological distress and suicidal behavior, independent of substance abuse and parental support in adolescents. Secondary analysis of data from the Global School-based Student Health Survey from Kiribati, the Solomon Islands, and Vanuatu was conducted. Binomial logistic regression analysis was used to examine the association of being bullied, fighting and injury with psychological health outcomes (loneliness, insomnia, suicidal ideation and suicide attempt) at a 5% level of significance...
July 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28713715/hand-injuries-by-the-killer-kite-manja-and-their-management
#6
Mohd Altaf Mir, Adil Mahmud Ali, Mohd Yaseen, Arshad Hafeez Khan
Although hand injuries due to kite strings seem to be trivial, these injuries could be serious enough to lose the function of hand. This case series in the division of Plastic and Reconstructive Surgery of our institution from August 2014 to January 2016 evaluated the clinic-etiological profile, severity and management of hand injuries due to kite strings assessed clinically and radiologically. Eleven patients reported kite related injuries during two years, and 5 presented during 17 months. Of 11 patients, 8 were male and 3 were female with a M:F ratio of 2...
May 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/28712118/farm-injury-hospitalisations-in-new-south-wales-2010-to-2014
#7
Tony Lower, Rebecca J Mitchell
OBJECTIVE: To examine gender differences in the characteristics, treatment costs and health outcomes of farm injuries resulting in hospitalisation of New South Wales (NSW) residents. METHOD: A population-based study of individuals injured on a farm and admitted to hospital using linked hospital admission and mortality records from 1 January 2010 to 30 June 2014 in NSW. Health outcomes, including injury severity, hospital length of stay (LOS), 28-day readmission and 30-day mortality were examined by gender...
July 16, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28710974/predictors-of-recovery-in-cyclists-hospitalised-for-orthopaedic-trauma-following-an-on-road-crash
#8
Ben Beck, Christina L Ekegren, Peter Cameron, Elton R Edwards, Andrew Bucknill, Rodney Judson, Richard Page, Raphael Hau, Mark Stevenson, Belinda J Gabbe
BACKGROUND: As cycling-related injury rates are on the rise, there is a need to understand the long term outcomes of these patients in order to quantify the burden of injury and to inform injury prevention strategies. This study aimed to investigate predictors of return to work and functional recovery in a cohort of cyclists hospitalised for orthopaedic trauma from crashes occurring on-road. METHODS: A retrospective analysis of data from the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR) was conducted for patients who were hospitalised for orthopaedic trauma following a cycling crash that occurred on-road between July 2007 and June 2015...
July 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28710023/transient-brain-hypothermia-reduces-the-reperfusion-injury-of-delayed-tissue-plasminogen-activator-and-extends-its-therapeutic-time-window-in-a-focal-embolic-stroke-model
#9
Mohammadreza Zarisfi, Fatemeh Allahtavakoli, Mahsa Hassanipour, Mohammad Khaksari, Hosain Rezazadeh, Mohammad Allahtavakoli, Mohammad Mohsen Taghavi
It has been reported that restriction of reperfusion after thrombolytic therapy in ischemic stroke may reduce tissue plasminogen activator (tPA) adverse effects and extend its time window. We examined whether short-term and mild local brain cooling can prevent hyperemia and/or adverse effects of delayed tPA in rat embolic stroke model. Male animals were subjected to embolic stroke and then randomly classified into control (saline), tPA (1mg/kg; i.v.), local hypothermia (LH), and tPA+LH. The drug was injected at 6h after ischemia...
July 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28708704/shoulder-injuries-in-canoeing-and-kayaking
#10
Philip Holland, Emma Torrance, Lennard Funk
OBJECTIVE: We report the largest case series of shoulder injuries among paddlers so far to establish common mechanisms and patterns of injury. We also discuss how these injuries were managed and report the proportion of paddlers that return to paddlesport. DESIGN: Case series. SETTING: Upper Limb Unit, Wrightington Hospital, United Kingdom. Manchester Arm Clinic, United Kingdom. PATIENTS: Fifty-seven shoulder injuries to professional and recreational paddlers were reviewed at a mean follow-up time of 55 months from the first consultation...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28706986/liver-preservation-by-aortic-perfusion-alone-compared-with-preservation-by-aortic-perfusion-and-additional-arterial-ex-situ-back-table-perfusion-with-histidine-tryptophan-ketoglutarate-solution-a-prospective-randomized-controlled-multicenter-study
#11
Gerd Otto, Michael Heise, Jochen Thies, Michael Pitton, Jens Schneider, Gernot Kaiser, Peter Neuhaus, Otto Kollmar, Michael Barthels, Josef Geks, Wolf Otto Bechstein, Achim Hellinger, Jürgen Klempnauer, Winfried Padberg, Nils Frühauf, Andre Ebbing, Dietmar Mauer, Astrid Schneider, Robert Kwiecien, Kai Kronfeld
BACKGROUND: Arterial ex situ back-table perfusion (BP) reportedly reduces ischemic-type biliary lesion after liver transplantation. We aimed to verify these findings in a prospective investigation. METHODS: Our prospective, randomized, controlled, multicenter study involved livers retrieved from patients in 2 German regions, and compared the outcomes of standard aortic perfusion to those of aortic perfusion combined with arterial ex situ BP. The primary endpoint was the incidence of ischemic-type biliary lesions over a follow-up of 2 years after liver transplantation, whereas secondary endpoints included 2-year graft survival, initial graft damage as reflected by transaminase levels, and functional biliary parameters at 6 months after transplantation...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28704884/prone-hip-extension-muscle-recruitment-is-associated-with-hamstring-injury-risk-in-amateur-soccer
#12
Joke Schuermans, Damien Van Tiggelen, Erik Witvrouw
'Core stability' is considered essential in rehabilitation and prevention. Particularly with respect to hamstring injury prevention, assessment and training of lumbo-pelvic control is thought to be key. However, supporting scientific evidence is lacking. To explore the importance of proximal neuromuscular function with regard to hamstring injury susceptibility, this study investigated the association between the Prone Hip Extension (PHE) muscle activation pattern and hamstring injury incidence in amateur soccer players...
July 13, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28703117/early-diagnostics-of-temporomandibular-joint-structural-elements-injures-caused-by-traumatic-mandibular-bone-fractures
#13
Kh R Pohranychna, A R Stasyshyn, U D Matolych
A rapidly increasing number of mandibular condylar fractures and some complications related to injuries of temporomandibular elements make this study important. Intra-articular disorders lead to secondary pathological findings such as osteoarthritis, deforming osteoarthrosis, and temporomandibular joint ankylosis that limits mouth opening, mastication, swallowing, breathing, and decreased/lost working capacity or disability. Early diagnosis of intra-articular disorders can prevent from long-lasting functional complications caused by temporomandibular joint injuries...
June 30, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28702713/the-role-of-the-oligodendrocyte-lineage-in-acute-brain-trauma
#14
Anja Scheller, Xianshu Bai, Frank Kirchhoff
An acute brain injury is commonly characterized by an extended cellular damage. The post-injury process of scar formation is largely determined by responses of various local glial cells and blood-derived immune cells. The role of astrocytes and microglia have been frequently reviewed in the traumatic sequelae. Here, we summarize the diverse contributions of oligodendrocytes (OLs) and their precursor cells (OPCs) in acute injuries. OLs at the lesion site are highly sensitive to a damaging insult, provoked by Ca(2+) overload after hyperexcitation originating from increased levels of transmitters...
July 12, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28702596/characterization-and-cardioprotective-activity-of-anthocyanins-from-nitraria-tangutorum-bobr-by-products
#15
Ming Zhang, Jianbin Ma, Hongtao Bi, Jiayin Song, Hongxia Yang, Zhenghua Xia, Yuzhi Du, Tingting Gao, Lixin Wei
The Nitraria tangutorum Bobr. fruit is an indigenous berry of the shrub belonging to the Zygophyllaceae family which grows at an altitude of over 3000 m in the Tibetan Plateau, and has been used as a native medicinal food for treating weakness of the spleen, stomach syndrome, dyspepsia, neurasthenia, dizziness, etc. for thousands of years. Nowadays, N. tangutorum industrial juice by-products generated from health food production can be a potential low cost source of some unique bioactive ingredients. In a prior study, we established a simultaneous microwave/ultrasonic assisted enzymatic extraction method for extracting antioxidant ingredients from the industrial by-products of N...
July 13, 2017: Food & Function
https://www.readbyqxmd.com/read/28697020/good-news-bad-news-an-analysis-of-11-294-gunshot-wounds-gsws-over-two-decades-in-a-single-center
#16
Nathan R Manley, Timothy C Fabian, John P Sharpe, Louis J Magnotti, Martin A Croce
INTRODUCTION: Gun violence is a substantial public health problem accounting for significant physical, psychological and financial costs. While aggregate data sources demonstrate decreasing rates of firearm violence, analyses from individual trauma centers have shown that mortality and injury severity from GSWs are increasing. To evaluate the evolving characteristics of gun violence in our region, we studied all GSWs admitted to our trauma center over a twenty-year period. METHODS: A retrospective analysis of all newly admitted patients with GSWs was performed from 1996 to 2016...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28694684/comparison-of-joint-loading-in-badminton-lunging-between-professional-and-amateur-badminton-players
#17
Lin Fu, Feng Ren, Julien S Baker
The knee and ankle are the two most injured joints associated with the sport of badminton. This study evaluates biomechanical factors between professional and amateur badminton players using an injury mechanism model. The aim of this study was to investigate the kinematic motion and kinetic loading differences of the right knee and ankle while performing a maximal right lunge. Amateur players exhibited greater ankle range of motion (p < 0.05, r = 0.89) and inversion joint moment (p < 0.05, r = 0.54) in the frontal plane as well as greater internal joint rotation moment (p < 0...
2017: Applied Bionics and Biomechanics
https://www.readbyqxmd.com/read/28693196/early-diagnosis-of-venous-thromboembolism-as-a-clinical-primary-symptom-of-occult-cancer-core-proteins-of-a-venous-thrombus
#18
Siwan Wen, Qianglin Duan, Fan Yang, Guiyuan Li, Lemin Wang
Malignancy is one of the risk factors of venous thromboembolism (VTE). As a common accompanying factor of malignant tumors, almost 20% of idiopathic VTEs are identified in patients with occult types of cancer as the primary symptom. The type of internal association that exists between malignant tumors and VTE has not yet been determined. The present review discusses the following: i) Reversible combinations between core proteins of venous thrombi and their ligand proteins. With the condition of immune cell balancing function collapse, which is characterized as dysfunction immune cells and impaired immune functions, the human body loses the function of eliminating infectious/malignant cells quickly and effectively...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690205/bronchoalveolar-lavage-microvesicles-protect-burn-injured-mice-from-pulmonary-infection
#19
Teresa C Rice, Amanda M Pugh, Brent T Xia, Aaron P Seitz, Brynne E Whitacre, Erich Gulbins, Charles C Caldwell
BACKGROUND: Pseudomonas aeruginosa (PA) is a major cause of morbidity and mortality among burn patients, despite antibiotic therapy. There is a need to identify innate immune defenses that prevent PA infection in injured adults in an effort to find therapeutic alternatives to antibiotics. Here, we tested our hypothesis that Microvesicles (MVs) in bronchoalveolar (BAL) fluid have a role in the immunity of the lung in response to pathogens. STUDY DESIGN: MVs were isolated from murine BAL fluid, quantified using nanoparticle tracking analysis, and injected into burn injured mice prior to PA infection...
July 6, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28689460/global-threats-from-preventable-injuries
#20
Jennan A Phillips
Preventable injuries kill thousands of the world's population every day and injure millions each year. Road traffic crashes and opioid drug misuse are major causes of these injuries. Increased efforts are needed to promote strong policies, develop new prevention strategies, and protect workers from these global public health threats.
July 1, 2017: Workplace Health & Safety
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