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https://www.readbyqxmd.com/read/27907960/multimodality-monitoring-illuminating-the-comatose-human-brain
#1
Charles L Francoeur, Margaret Pain, Stephan A Mayer
The field of neurocritical care has evolved tremendously in recent years, a development explained vastly by the advent of neurophysiological monitoring. From basic intracranial pressure measurements to brain tissue oxygenation, microdialysis, cerebral blood flow (CBF), and surface and intracortical electroencephalography (EEG), our ability to detect and control physiologic endpoints of brain function in comatose patients has grown substantially. The integration of these data gave birth to the concept of multimodality monitoring (MMM)...
December 2016: Seminars in Neurology
https://www.readbyqxmd.com/read/27900178/self-reported-worst-injuries-in-women-s-australian-football-identify-lower-limb-injuries-as-a-prevention-priority
#2
Lauren V Fortington, Alex Donaldson, Caroline F Finch
BACKGROUND: Increasing participation by women in Australian football (AF) has made understanding their specific injury prevention needs a priority. In other sports, men and women have different injury profiles. This study aims to provide the first overview of self-reported injuries in women's AF. METHODS: Nationwide survey of women aged 17+ years who played in an AF competition was conducted following the 2014 playing season. The players' self-reported worst injury from the 2014 season is presented according to injury type, body part injured, treatment sought and games/training missed...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900149/video-analysis-of-concussion-injury-mechanism-in-under-18-rugby
#3
Sharief Hendricks, Sam O'Connor, Michael Lambert, James C Brown, Nicholas Burger, Sarah Mc Fie, Clint Readhead, Wayne Viljoen
BACKGROUND: Understanding the mechanism of injury is necessary for the development of effective injury prevention strategies. Video analysis of injuries provides valuable information on the playing situation and athlete-movement patterns, which can be used to formulate these strategies. Therefore, we conducted a video analysis of the mechanism of concussion injury in junior-level rugby union and compared it with a representative and matched non-injury sample. METHODS: Injury reports for 18 concussion events were collected from the 2011 to 2013 under-18 Craven Week tournaments...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27895932/coagulation-complications-following-trauma
#4
REVIEW
Wenjun Z Martini
Traumatic injury is one of the leading causes of death, with uncontrolled hemorrhage from coagulation dysfunction as one of the main potentially preventable causes of the mortality. Hypothermia, acidosis, and resuscitative hemodilution have been considered as the significant contributors to coagulation manifestations following trauma, known as the lethal triad. Over the past decade, clinical observations showed that coagulopathy may be present as early as hospital admission in some severely injured trauma patients...
2016: Military Medical Research
https://www.readbyqxmd.com/read/27894500/prediction-of-massive-transfusion-in-trauma
#5
REVIEW
Paul M Cantle, Bryan A Cotton
Hemorrhage is the leading cause of preventable death in trauma. Damage control resuscitation relies on permissive hypotension, minimizing crystalloid use, and early implementation of massive transfusion protocols with established blood component ratios. These protocols improve the survival of the severely injured patient. Trauma physicians must quickly and accurately predict when a massive transfusion protocol should be activated. Several validated transfusion scores have been developed for this purpose. Many of these scores are useful for resuscitation research...
January 2017: Critical Care Clinics
https://www.readbyqxmd.com/read/27885575/administration-of-huperzia-quadrifariata-extract-a-cholinesterase-inhibitory-alkaloid-mixture-has-neuroprotective-effects-in-a-rat-model-of-cerebral-hypoxia-ischemia
#6
F K Odorcyk, E F Sanches, F C Nicola, J Moraes, L F Pettenuzzo, J Kolling, C Siebert, A Longoni, E L Konrath, A Wyse, C A Netto
Neonatal hypoxia-ischemia (HI) is an etiologic component of several neurologic pathologies associated to cognitive impairment. The mechanisms involved in HI-induced tissue damage start immediately after HI and extend for days. Acetylcholine is an important neurotransmitter in the central nervous system and exerts a protector effect on tissue damage by modulating inflammation, and cholinesterase inhibitors have shown neuroprotective properties and their action are often attributed to inhibition of the immune response...
November 24, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27884941/developing-predictive-models-for-return-to-work-using-the-military-power-performance-and-prevention-mp3-musculoskeletal-injury-risk-algorithm-a-study-protocol-for-an-injury-risk-assessment-programme
#7
Daniel I Rhon, Deydre S Teyhen, Scott W Shaffer, Stephen L Goffar, Kyle Kiesel, Phil P Plisky
BACKGROUND: Musculoskeletal injuries are a primary source of disability in the US Military, and low back pain and lower extremity injuries account for over 44% of limited work days annually. History of prior musculoskeletal injury increases the risk for future injury. This study aims to determine the risk of injury after returning to work from a previous injury. The objective is to identify criteria that can help predict likelihood for future injury or re-injury. METHODS: There will be 480 active duty soldiers recruited from across four medical centres...
November 24, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27884864/sports-injuries-and-illnesses-in-the-lillehammer-2016-youth-olympic-winter-games
#8
Kathrin Steffen, Christine Holm Moseid, Lars Engebretsen, Pia K Søberg, Olav Amundsen, Kristian Holm, Thomas Moger, Torbjørn Soligard
BACKGROUND: Injury and illness surveillance during high-level youth sports events is an important first step in health prevention and caretaking of the young elite athletes. AIM: To analyse injuries and illnesses that occurred during the 10 days 2nd Youth Olympic Winter Games (YOG), held in Lillehammer 2016. METHODS: We recorded the daily occurrence (or non-occurrence) of injuries and illnesses through the reporting of (1) all National Olympic Committee (NOC) medical teams and (2) the polyclinic and medical venues by the Lillehammer Organising Committee (LYOCOG) medical staff...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27879505/the-effect-of-transpedicular-screw-design-on-its-performance-in-vertebral-bone-under-tensile-loads-a-parametric-study
#9
Ron N Alkaly, Dan L Bader
STUDY DESIGN: A biomechanical study using bovine thoracolumbar spines. OBJECTIVE: To study investigated whether thread design parameters aimed at altering the state of stress at the screw-bone interface increase the screw's holding power. SUMMARY AND BACKGROUND DATA: Internal spinal fixators utilizing transpedicular screw fixation are used to achieve early stabilization of the injured spine in a range of clinical conditions. Despite advances in the design of internal spinal fixation systems, implant loosening, and catastrophic failures at the screw-bone interface remains a serious complication in adult spine surgery...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27878687/aptamers-against-pro-and-anti-inflammatory-cytokines-a-review
#10
REVIEW
Maryam Boshtam, Seddigheh Asgary, Shirin Kouhpayeh, Laleh Shariati, Hossein Khanahmad
Inflammatory disorders result from continuous inflammation in injured sites. Many molecules are involved in this process; the inhibition of which could prevent the inflammation. Chemokines are a group of these biological mediators which are categorized into pro-, anti-, and pro-/anti-inflammatory. Thus, targeting these essential molecules can be an effective way for prevention and control of inflammatory diseases. Various therapeutic agents have been developed for primary and secondary prevention of these disorders, but each of them has its own limitations...
November 23, 2016: Inflammation
https://www.readbyqxmd.com/read/27878129/an-epidemiological-study-of-road-traffic-accidents-in-guilan-province-northern-iran-in-2012
#11
Zahra Mohtasham-Amiri, Saeed Dastgiri, Ali Davoudi-Kiakalyeh, Ali Imani, Keyvan Mollarahimi
OBJECTIVE: To determine the epidemiological characteristics of the road traffic injuries (RTIs) in Guilan province, northern Iran. METHODS: This study was a cross-sectional study which included all of RTIs admitted to medical centers of Guilan province (northern Iran) during 2012. ICD-10 was used as diagnostic criteria. Demographic variables also injury circumstance and in hospital variables such as length of stay, time of admission, type of surgery, ICU admission, final outcome and mechanism of injury, anatomical part of injury according to Abbreviated Injury Scale (AIS) classification were derives from records by trained research team...
October 2016: Bulletin of Emergency and Trauma
https://www.readbyqxmd.com/read/27876077/post-traumatic-acute-kidney-injury-a-cross-sectional-study-of-trauma-patients
#12
Wei-Hung Lai, Cheng-Shyuan Rau, Shao-Chun Wu, Yi-Chun Chen, Pao-Jen Kuo, Shiun-Yuan Hsu, Ching-Hua Hsieh, Hsiao-Yun Hsieh
BACKGROUND: The causes of post-traumatic acute kidney injury (AKI) are multifactorial, and shock associated with major trauma has been proposed to result in inadequate renal perfusion and subsequent AKI in trauma patients. This study aimed to investigate the true incidence and clinical presentation of post-traumatic AKI in hospitalized adult patients and its association with shock at a Level I trauma center. METHODS: Detailed data of 78 trauma patients with AKI and 14,504 patients without AKI between January 1, 2009 and December 31, 2014 were retrieved from the Trauma Registry System...
November 22, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27872763/effects-of-microtubule-stabilization-by-epothilone-b-depend-on-the-type-and-age-of-neurons
#13
Eun-Hae Jang, Aeri Sim, Sun-Kyoung Im, Eun-Mi Hur
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury and neurodegenerative diseases. Paradoxically, administration of MSAs, which have been widely prescribed to treat malignancies, is well known to cause debilitating peripheral neuropathy and axon degeneration. Despite the growing interest of applying MSAs to treat the injured or degenerating central nervous system (CNS), consequences of MSA exposure to neurons in the central and peripheral nervous system (PNS) have not been thoroughly investigated...
2016: Neural Plasticity
https://www.readbyqxmd.com/read/27872744/association-between-sports-type-and-overuse-injuries-of-extremities-in-children-and-adolescents-a-systematic-review
#14
REVIEW
Charlène Chéron, Christine Le Scanff, Charlotte Leboeuf-Yde
BACKGROUND: Sporting activities can cause injuries and overuse injuries of the extremities (OIE) in children have been shown to be more common than injuries caused by trauma. The lower extremity is more frequently affected than the upper extremity in OIE, but it is not known whether injury site and diagnosis vary in different sporting activities. PURPOSE: To identify any differences between sports in relation to diagnoses and anatomical areas most likely to be injured...
2016: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/27871857/bmi-1-plays-a-critical-role-in-the-protection-from-acute-tubular-necrosis-by-mobilizing-renal-stem-progenitor-cells
#15
Xianhui Lv, Zhenzhen Yu, Chunfeng Xie, Xiuliang Dai, Qing Li, Dengshun Miao, Jianliang Jin
The regeneration of injured tubular cell occurs primarily from intrinsic renal stem/progenitor cells (RSCs) labeled with CD24 and CD133 after acute tubular necrosis (ATN). Bmi-1 plays a crucial role in regulating self-renewal, differentiation and aging of multiple adult stem cells and progenitor cells. Bmi-1 was rapidly elevated in the induction of adult kidney regeneration by renal injury. To determine whether Bmi-1 maintained mobilization of RSCs in the protection from ATN, glycerol-rhabdomyolysis-induced ATN were performed in wild type (WT) and Bmi-1-deficient (Bmi-1(-/-)) mice...
November 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27871653/surgical-management-and-treatment-of-the-anterior-cruciate-ligament-posterolateral-corner-injured-knee
#16
REVIEW
Nicholas I Kennedy, Christopher M LaPrade, Robert F LaPrade
Posterolateral knee injuries occur more commonly than in the past. These injuries most commonly occur concurrent with cruciate ligament tears. The main stabilizers of the posterolateral knee are the fibular collateral ligament, the popliteus tendon, and the popliteofibular ligament. These static stabilizers function to prevent increased varus, external rotation, and coupled posterolateral rotation of the knee. The most important clinical tests to diagnose posterolateral knee injuries are the varus stress test, posterolateral drawer, and dial tests...
January 2017: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27870992/nanoencapsulation-of-coenzyme-q10-and-vitamin-e-acetate-protects-against-uvb-radiation-induced-skin-injury-in-mice
#17
Natháli S Pegoraro, Allanna V Barbieri, Camila Camponogara, Juliane Mattiazzi, Evelyne S Brum, Marila C L Marchiori, Sara M Oliveira, Letícia Cruz
This study aimed to investigate the feasibility of producing semisolid formulations based on nanocapsule suspensions containing the association of the coenzyme Q10 and vitamin E acetate by adding gellan gum (2%) to the suspensions. Furthermore, we studied their application as an alternative for the treatment of inflammation induced by ultraviolet B (UVB) radiation. For this, an animal model of injury induced by UVB-radiation was employed. All semisolids presented pH close to 5.5, drug content above 95% and mean diameter on the nanometric range, after redispersion in water...
November 9, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27869953/profile-of-work-related-road-traffic-accident-victims-recorded-by-sentinel-health-units-in-pernambuco-brazil-2012-2014
#18
Caroline Cordeiro Souto, Flávia Karina Wanderley Reis, Raphaella Patrícia Torres Bertolini, Rosimeiry Santos de Melo Almeida Lins, Sandra Luzia Barbosa de Souza
OBJECTIVE: to describe the profile of work-related road traffic accident (RTA) victims, reported by Road Traffic Accident Information Sentinel Units in the state of Pernambuco, Brazil, from 2012-2014. METHODS: descriptive study of fatal and non-fatal work-related road traffic accident victims, reported by 21 RTA Information Sentinel Units in Pernambuco. RESULTS: 87.8% of the 10,691 cases reported occurred among males; 69.0% of all records were related to the 20-39 age group; the sectors with most injured workers were Transport (24...
April 2016: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
https://www.readbyqxmd.com/read/27865767/neural-stem-cells-promote-nerve-regeneration-through-il12-induced-schwann-cell-differentiation
#19
Don-Ching Lee, Jong-Hang Chen, Tai-Yu Hsu, Li-Hsun Chang, Hsu Chang, Ya-Hui Chi, Ing-Ming Chiu
Regeneration of injured peripheral nerves is a slow, complicated process that could be improved by implantation of neural stem cells (NSCs) or nerve conduit. Implantation of NSCs along with conduits promotes the regeneration of damaged nerve, likely because (i) conduit supports and guides axonal growth from one nerve stump to the other, while preventing fibrous tissue ingrowth and retaining neurotrophic factors; and (ii) implanted NSCs differentiate into Schwann cells and maintain a growth factor enriched microenvironment, which promotes nerve regeneration...
November 16, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27863189/hemophilia-in-sports-a-case-report-and-prophylactic-protocol
#20
Mark Maffet, Jimmy Roton
OBJECTIVE:   To describe a successful prophylactic protocol for managing an athlete with hemophilia playing at a high level of contact sports. BACKGROUND:   Published data show that team physicians are not comfortable either treating athletes with bleeding disorders or allowing them to participate in contact sports. Much of the literature historically has recommended against allowing athletes with bleeding disorders to play sports at all and certainly against playing contact sports...
November 18, 2016: Journal of Athletic Training
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