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https://www.readbyqxmd.com/read/28535416/the-role-of-timing-in-the-treatment-of-spinal-cord-injury
#1
REVIEW
Amene Saghazadeh, Nima Rezaei
Regeneration failure after primary spinal cord injury (SCI) leads to diverse clinical complications in a severity- and level of SCI-dependent manner. The cost of treating both of them (initial regeneration failure and following complications) would be prohibitive, particularly in less developed nations. The well-recognized circumstances arose from primary SCI include excitotoxicity and inflammation. SCI increases concentrations of extracellular amino acids (EAAs) in the severity-dependent manner and the maximum level of EAAs at the injury site will be reduced by distance from the injury site...
May 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28529012/the-epidemiology-and-hotspots-of-road-traffic-injuries-in-moshi-tanzania-an-observational-study
#2
Joseph M Reardon, Luciano Andrade, Julian Hertz, George Kiwango, Anneth Teu, Msafiri Pesambili, Deena El-Gabri, Michael Hocker, Mark Mvungi, João Ricardo N Vissoci, Catherine A Staton
Road traffic injuries (RTIs) continue to increase with the proliferation of motor vehicles, especially in low-income countries where safe road infrastructure is lacking. Knowing where and why RTIs occur would allow for increased safety and prevention planning. In this study, police records of 300 motor vehicle collisions which occurred between February 2013 and January 2014 in Moshi, Tanzania were reviewed. Analysis of variables including victim age, gender, type of collision, conditions, and use of safety equipment were analyzed...
May 3, 2017: Injury
https://www.readbyqxmd.com/read/28526035/microblogging-violent-attacks-on-medical-staff%C3%A2-in-china-a-case-study-of-the-longmen-county-people-s-hospital-incident
#3
Jia Tian, Li Du
BACKGROUND: A violent attack on medical staff in Guangdong Province, in which a female doctor at Longmen County People's Hospital (LCPH) was severely injured by a knife-wielding patient, has drawn significant public attention to the phenomenon of hospital violence and initiated discussions on how to resolve violence in hospitals. Social networking sites, such as Sina Weibo, a Chinese version of Twitter, have played a role in this public debate. The incident at LCPH provides an opportunity to examine how Weibo has been used in the debate about violence against medical staff in China...
May 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28524081/protective-effects-of-tormentic-acid-a-major-component-of-suspension-cultures-of-eriobotrya-japonica-cells-on-acetaminophen-induced-hepatotoxicity-in-mice
#4
Wen-Ping Jiang, Shyh-Shyun Huang, Yoshikazu Matsuda, Hiroshi Saito, Naoto Uramaru, Hui-Ya Ho, Jin-Bin Wu, Guan-Jhong Huang
An acetaminophen (APAP) overdose can cause hepatotoxicity and lead to fatal liver damage. The hepatoprotective effects of tormentic acid (TA) on acetaminophen (APAP)-induced liver damage were investigated in mice. TA was intraperitoneally (i.p.) administered for six days prior to APAP administration. Pretreatment with TA prevented the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T-Bil), total cholesterol (TC), triacylglycerol (TG), and liver lipid peroxide levels in APAP-treated mice and markedly reduced APAP-induced histological alterations in liver tissues...
May 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28515975/prospective-functional-performance-testing-and-relationship-to-lower-extremity-injury-incidence-in-adolescent-sports-participants
#5
Joseph Smith, Nick DePhillipo, Iris Kimura, Morgan Kocher, Ronald Hetzler
BACKGROUND: Due to the high number of adolescent athletes and subsequent lower extremity injuries, improvements of injury prevention strategies with emphasis on clinic-based and practical assessments are warranted. PURPOSE: The purpose of this study was to prospectively investigate if a battery of functional performance tests (FPT) could be used as a preseason-screening tool to identify adolescent athletes at risk for sports-related acute lower extremity injury via comparison of injured and uninjured subjects...
April 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28513281/short-term-effects-of-kinesio-taping-on-muscle-recruitment-order-during-a-vertical-jump-a-pilot-study
#6
Guillermo Mendez-Rebolledo, Rodrigo Ramirez-Campillo, Eduardo Guzman-Muñoz, Valeska Gatica-Rojas, Alexis Dabanch-Santis, Francisco Diaz-Valenzuela
CONTEXT: Kinesio taping is commonly used in sports and rehabilitation settings with the aim of prevention and treatment of musculoskeletal injuries. However, limited evidence exists regarding the effects of 24 and 72 h of kinesio taping on trunk and lower limb neuromuscular and kinetic performance during a vertical jump. OBJECTIVE: The purpose of this study was to analyze the short-term effects of kinesio taping on the height and ground reaction force during a vertical jump, in addition to trunk and lower limb muscle latency and recruitment order...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28512475/risk-factors-for-road-traffic-injuries-among-different-road-users-in-the-gambia
#7
Edrisa Sanyang, Corinne Peek-Asa, Paul Bass, Tracy L Young, Babanding Daffeh, Laurence J Fuortes
We identified risk factors for road traffic injuries among road users who received treatment at two major trauma hospitals in urban Gambia. The study includes pedestrians, bicyclists, motorcyclists, and drivers/passengers of cars and trucks. We examined distributions of injury by age, gender, collision vehicle types and vehicle category, and driver and environment factors. Two hundred and fifty-four patients were included in the study. Two-thirds were male and one-third female. Two-thirds (67%) of road traffic injuries involved pedestrians, bicyclists, and motorcyclists; and these were more common during weekdays (74%) than weekends...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28510466/empirical-bayesian-geographical-mapping-of-occupational-accidents-among-iranian-workers
#8
Nasim Vahabi, Anoshirvan Kazemnejad, Somnath Datta
BACKGROUND: Work-related accidents are believed to be a serious preventable cause of mortality and disability worldwide. This study aimed to provide Bayesian geographical maps of occupational injury rates among workers insured by the Iranian Social Security Organization. METHODS: The participants included all insured workers in the Iranian Social Security Organization database in 2012. One of the applications of the Bayesian approach called the Poisson-Gamma model was applied to estimate the relative risk of occupational accidents...
May 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28510368/escalator-related-injuries-in-30-dogs-2007-2014
#9
Emma-Leigh Pearson, Megan Whelan, Kiko Bracker
OBJECTIVE: To describe a population of dogs affected by escalator-related injuries, and to characterize the types of injuries sustained and describe treatment administered. DESIGN: Retrospective study from March 2007 to November 2014. SETTING: Large urban referral and emergency facility. ANIMALS: Thirty client-owned dogs presenting with injuries acquired while riding an escalator. INTERVENTIONS: None...
May 16, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28505239/foxo1-promotes-mitophagy-in-the-podocytes-of-diabetic-male-mice-via-the-pink1-parkin-pathway
#10
Wen Li, Mengmeng Du, Qingzhu Wang, Xiaojun Ma, Lina Wu, Feng Guo, Hongfei Ji, Fengjuan Huang, Guijun Qin
We recently showed that Forkhead-box class O1 (FoxO1) activation protects against high glucose-induced injury by preventing mitochondrial dysfunction in the rat kidney cortex. In addition, FoxO1 has been reported to mediate PINK1 transcription and promote autophagy in response to mitochondrial oxidative stress in murine cardiomyocytes. In this study, we ascertained whether over-expressing FoxO1 in the kidney cortex reverses pre-established diabetic nephropathy in animal models. The effect of FoxO1 on mitophagy signaling pathways was evaluated in mouse podocytes...
May 12, 2017: Endocrinology
https://www.readbyqxmd.com/read/28499094/the-epidemiology-and-effect-of-sliding-injuries-in-major-and-minor-league-baseball-players
#11
Christopher L Camp, Frank C Curriero, Keshia M Pollack, Stephanie W Mayer, Andrea M Spiker, John D'Angelo, Struan H Coleman
BACKGROUND: Although sliding occurs frequently in professional baseball, little is known about the epidemiology and effect of injuries that occur during sliding in this population of elite athletes. PURPOSE: To describe the incidence and characteristics of sliding injuries, determine their effect in terms of time out of play, and identify common injury patterns that may represent appropriate targets for injury prevention programs in the future. STUDY DESIGN: Descriptive epidemiologic study...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28498296/interleukin-22-prevents-microbial-dysbiosis-and-promotes-intestinal-barrier-regeneration-following-acute-injury
#12
Adam M Hammer, Niya L Morris, Abigail R Cannon, Omair M Khan, Robin C Gagnon, Nellie V Movtchan, Ilse van Langeveld, Xiaoling Li, Bin Gao, Mashkoor A Choudhry
Intestine barrier disruption and bacterial translocation can contribute to sepsis and multiple organ failure- leading causes of mortality in burn-injured patients. Additionally, findings suggest ethanol (alcohol) intoxication at the time of injury worsens symptoms associated with burn injury. We have previously shown that interleukin-22 (IL-22) protects from intestinal leakiness and prevents overgrowth of Gram-negative bacteria following ethanol and burn injury, but how IL-22 mediates these effects has not been established...
May 11, 2017: Shock
https://www.readbyqxmd.com/read/28497421/decreased-mir-128-and-increased-mir-21-synergistically-cause-podocyte-injury-in-sepsis
#13
Shanshan Wang, Jun Wang, Zengdi Zhang, Hongjun Miao
OBJECTIVE: Glomerular podocytes are injured in sepsis. We studied, in a sepsis patient, whether microRNAs (miRNAs) play a role in the podocyte injury. METHODS: Podocytes were cultured and treated with lipopolysaccharide (LPS). Filtration barrier function of podocyte was analyzed with albumin influx assay. Nephrin level was analyzed with reverse transcription polymerase chain reaction (RT-PCR) and western blot. MiRNAs were detected using miRNAs PCR Array and in situ hybridization...
May 11, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28489471/effect-of-the-2011-revisions-to-the-field-triage-guidelines-on-under-and-over-triage-rates-for-pediatric-trauma-patients
#14
E Brooke Lerner, Jeremy T Cushman, Amy L Drendel, Mohamed Badawy, Manish N Shah, Clare E Guse, Arthur Cooper
BACKGROUND: In 2011, revised Field Triage Guidelines were released jointly by the Centers for Disease Control and Prevention (CDC) and the American College of Surgeons - Committee on Trauma (ACS-COT). It is unknown how the modifications will affect the number of injured children identified by EMS providers as needing transport to a trauma center. OBJECTIVE: To determine the change in under- and over-triage rates when the 2011 Field Triage Guidelines are compared to the 2006 and 1999 versions...
May 10, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28488337/affinity-immobilization-of-vegf-on-laminin-porous-sponge-enhances-angiogenesis-in-the-ischemic-brain
#15
Mio Oshikawa, Kei Okada, Naoko Kaneko, Kazunobu Sawamoto, Itsuki Ajioka
Ischemic brain stroke is caused by blood flow interruption, leading to focal ischemia, neuron death, and motor, sensory, and/or cognitive dysfunctions. Angiogenesis, neovascularization from existing blood vessel, is essential for tissue growth and repair. Proangiogenic therapy for stroke is promising for preventing excess neuron death and improving functional recovery. Vascular endothelial growth factor (VEGF) is a critical factor for angiogenesis by promoting the proliferation, the survival, and the migration of endothelial cells...
May 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28488001/lateral-displacement-sulcus-angle-and-trochlear-angle-are-associated-with-early-patellofemoral-osteoarthritis-following-anterior-cruciate-ligament-reconstruction
#16
Erin M Macri, Adam G Culvenor, Hayden G Morris, Timothy S Whitehead, Trevor G Russell, Karim M Khan, Kay M Crossley
PURPOSE: Patellofemoral osteoarthritis (PFOA) occurs in approximately half of anterior cruciate ligament (ACL)-injured knees within 10-15 years of trauma. Risk factors for post-traumatic PFOA are poorly understood. Patellofemoral alignment and trochlear morphology may be associated with PFOA following ACL reconstruction (ACLR), and understanding these relationships, particularly early in the post-surgical time period, may guide effective early intervention strategies. In this study, patellofemoral alignment and trochlear morphology were investigated in relation to radiographic features of early PFOA 1-year post-ACLR...
May 9, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28482342/pioglitazone-attenuates-injury-induced-neointima-formation-in-mouse-femoral-artery-partially-through-the-activation-of-amp-activated-protein-kinase
#17
Islam Osman, Arwa Fairaq, Lakshman Segar
BACKGROUND/AIMS: Pioglitazone (PIO), an antidiabetic drug, has been shown to attenuate vascular smooth muscle cell (VSMC) proliferation, which is a major event in atherosclerosis and restenosis after angioplasty. Till date, the likely contributory role of AMP-activated protein kinase (AMPK) toward PIO inhibition of VSMC proliferation has not been examined in vivo. This study is aimed at determining whether pharmacological inhibition of AMPK would prevent the inhibitory effect of PIO on neointima formation in a mouse model of arterial injury...
May 9, 2017: Pharmacology
https://www.readbyqxmd.com/read/28480187/application-of-temporary-inflow-control-of-the-glissonean-pedicle-method-provides-a-safe-and-easy-technique-for-totally-laparoscopic-hemihepatectomy-by-glissonean-approach
#18
Nuri Lee, Chan Woo Cho, Jong Man Kim, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh
The Glissonian approach, due to its simplicity of procedure, is a technical procedure widely used in open hepatectomy. However, it is not easily applicable in the setting of the total laparoscopic approach because of movement restriction. We herein propose a new and simple method of performing hemihepatectomy by Glissonian approach called temporary inflow control of the Glissonian pedicle (TICGL) technique. Dissection of the Glisson pedicle from the liver parenchyma is done until the posterior margin of the pedicle is visualized, and is clamped with bulldog clamps...
May 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28475020/anterior-cage-dislodgement-in-posterior-lumbar-interbody-fusion-a-review-of-12-patients
#19
Shuhei Murase, Yasushi Oshima, Yujiro Takeshita, Kota Miyoshi, Kazuhito Soma, Naohiro Kawamura, Junichi Kunogi, Takashi Yamazaki, Dai Ariyoshi, Shigeo Sano, Hirohiko Inanami, Katsushi Takeshita, Sakae Tanaka
OBJECTIVE Interbody fusion cages are widely used to achieve initial fixation and secure spinal fusion; however, there are certain technique-related complications. Although anterior cage dislodgement can cause major vascular injury, the incidence is extremely rare. Here, the authors performed a review of anterior cage dislodgement following posterior lumbar interbody fusion (PLIF) surgery. METHODS The authors retrospectively reviewed the cases of 4625 patients who had undergone PLIF at 6 institutions between December 2007 and March 2015...
May 5, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28469003/regulation-of-axonal-regeneration-following-spinal-cord-injury-in-the-lamrpey
#20
Jessica A Benes, Kylie N House, Frank N Burks, Kris P Conaway, Donald P Julien, Jeffrey P Donley, Michael A Iyamu, Andrew D McClellan
Following rostral spinal cord injury (SCI) in larval lampreys, injured descending brain neurons, particularly reticulospinal (RS) neurons, regenerate their axons, and locomotor behavior recovers in a few weeks. However, axonal regeneration of descending brain neurons is mostly limited to relatively short distances, but the mechanisms for incomplete axonal regeneration are unclear. First, lampreys with rostral SCI exhibited greater axonal regeneration of descending brain neurons, including RS neurons, as well as more rapid recovery of locomotor muscle activity right below the lesion site compared to animals with caudal SCI...
May 3, 2017: Journal of Neurophysiology
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