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https://www.readbyqxmd.com/read/29335599/hindlimb-ischemia-impairs-endothelial-recovery-and-increases-neointimal-proliferation-in-the-carotid-artery
#1
Sabato Sorrentino, Claudio Iaconetti, Salvatore De Rosa, Alberto Polimeni, Jolanda Sabatino, Clarice Gareri, Francesco Passafaro, Teresa Mancuso, Laura Tammè, Chiara Mignogna, Caterina Camastra, Giovanni Esposito, Antonio Curcio, Daniele Torella, Ciro Indolfi
Peripheral ischemia is associated with higher degree of endothelial dysfunction and a worse prognosis after percutaneous coronary interventions (PCI). However, the role of peripheral ischemia on vascular remodeling in remote districts remains poorly understood. Here we show that the presence of hindlimb ischemia significantly enhances neointima formation and impairs endothelial recovery in balloon-injured carotid arteries. Endothelial-derived microRNAs are involved in the modulation of these processes. Indeed, endothelial miR-16 is remarkably upregulated after vascular injury in the presences of hindlimb ischemia and exerts a negative effect on endothelial repair through the inhibition of RhoGDIα and nitric oxide (NO) production...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319654/trauma-and-intensive-care-nursing-knowledge-and-attitude-of-foley-catheter-insertion-and-maintenance
#2
Brenda Shaver, Stephanie A Eyerly-Webb, Zoe Gibney, Linda Silverman, Candace Pineda, Rachele J Solomon
In the acute care setting, the majority of urinary tract infections are associated with indwelling urinary catheters. Despite guidelines for proper use, catheter-associated urinary tract infections (CAUTIs) continue to occur in critically ill/injured patients. There is a paucity of data on the translation between CAUTI prevention education and behavioral change. This project evaluated nurse's clinical knowledge and attitude toward Foley catheter insertion and maintenance to determine the benefits of addressing gaps in knowledge and inconsistencies in attitude through education...
January 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29318177/injury-recurrence-among-high-school-athletes-in-the-united-states-a-decade-of-patterns-and-trends-2005-2006-through-2015-2016
#3
K Linnea Welton, Matthew J Kraeutler, Lauren A Pierpoint, Justin H Bartley, Eric C McCarty, R Dawn Comstock
Background: As participation in high school athletics increases, so does the number of adolescents experiencing sports-related injury. Understanding injury patterns is an important component to developing and evaluating prevention and rehabilitation programs. Purpose: To analyze recurrent injury rates and patterns among high school athletes, to compare recurrent injuries with new injuries, and to evaluate injury trends over time. Study Design: Descriptive epidemiology study...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29316593/demographics-of-tennis-related-injuries-that-presented-to-emergency-departments-in-the-united-states
#4
Jonathan D Chevinsky, Neil V Shah, Mikhail Tretiakov, Alexandr Aylyarov, Gregory S Penny, Joanne C Dekis, Jonathan N Chorney, Natasha Ahmed, Nipun Sodhi, Alyeesha B Wilhelm, William P Urban, Carl B Paulino, Jared M Newman
INTRODUCTION: Tennis injuries are not uncommon, and efforts have been made to reduce the risk of these injuries. There are a number of different factors that have been shown to influence injury rates of tennis players, in particular patient-related risks. Therefore, the purpose of this study was to investigate the epidemiology of tennis-related injuries. Specifically, we evaluated: 1) demographics; 2) incidence and trends of injuries; and 3) incidence and trends of body parts that were injured...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29315937/reported-safety-environment-predicts-injuries-among-children-aged-1-6-years-in-specific-communities
#5
Maya Siman-Tov, Kobi Peleg, Orna Baron-Epel
AIM: To measure individual and environmental risk factors predicting reported child injuries. METHODS: A prospective, follow-up study was performed including 380 parents of children aged 1-6 years, living in various communities throughout Israel. Parents were interviewed three times, 3 months apart. Injuries were defined as including minor injuries that required parental attention and medically attended injuries: doctor or nurse visit, emergency medical services or hospitalisation...
January 9, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29315468/when-do-trauma-patients-lose-temperature-a-prospective-observational-study
#6
S C Eidstuen, O Uleberg, G Vangberg, E Skogvoll
BACKGROUND: The prevalence of hypothermia in trauma patients is high and rapid recognition is important to prevent further heat loss. Hypothermia is associated with poor patient outcomes and is an independent predictor of increased mortality. The aim of this study was to analyze the changes in core body temperature of trauma patients during different treatment phases in the pre-hospital and early in-hospital settings. METHODS: A prospective observational cohort study in severely injured patients...
January 7, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29315449/trends-and-epidemiology-of-tennis-related-sprains-strains-in-the-united-states-2010-to-2016
#7
Jonathan D Chevinsky, Jared M Newman, Neil V Shah, Neel Pancholi, John Holliman, Nipun Sodhi, Ahmed Eldib, Qais Naziri, Bashir A Zikria, John P Reilly, Scott E Barbash, William P Urban
BACKGROUND: While tennis is one of the most popular sports in the world, it predisposes those who play it to a number of injuries. Several studies have shown sprains/strains to be the most common tennis-related injury. However, data is limited regarding trends in tennis-related sprains/strains. Therefore, this study evaluated: 1) trends in tennis-related sprains/strains; 2) trends in tennis-related sprains/strains by age; and 3) trends in the most common tennis-related sprained/strained body parts...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29312604/serum-amyloid-a-induces-m2b-like-macrophage-polarization-during-liver-inflammation
#8
Yibin Wang, Haijun Huang, Renhua Sun, Bingyu Chen, Fang Han, Qian Li, Yin Ni, Xi Li, Jingquan Liu, Xiaozhou Mou, Yuexing Tu
Hepatitis causes hepatic cell injury, regeneration and different levels of fibrogenesis, and severe liver fibrogenesis progresses into cirrhosis with liver dysfunction. Serum amyloid A (SAA) is an acute phase protein that is predominantly secreted by hepatocytes during early injury or infection. Nevertheless, the relationship of SAA and development of cirrhosis as well as the underlying molecular mechanisms is largely unknown. Here, we found that macrophages are the major SAA-binding cells in the injured liver...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29307126/incidence-and-characteristics-of-hospitalizations-after-dog-s-bite-injuries-in-sicily-italy-between-2012%C3%A2-2015
#9
Daniela Alberghina, Antonino Virga, Sergio Pio Buffa, Michele Panzera
There have been several studies focusing on dogs bite injuries and their epidemiology. To our knowledge, the incidence and characteristics of hospitalization after a dogs bite injury have not been examined quantitatively in Italy. The aim of this study was to identify the incidence and characteristics of dogs bite hospitalizations throughout Sicily (Italy) between 2012-2015. Data for statistical analysis were acquired through the Epidemiological Observatory and Health Department of Sicilian Region (Italy). One hundred and forty records with E-code 906...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29304749/what-works-in-falls-prevention-in-asia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Keith D Hill, Plaiwan Suttanon, Sang-I Lin, William W N Tsang, Asmidawati Ashari, Tengku Aizan Abd Hamid, Kaela Farrier, Elissa Burton
BACKGROUND: There is strong research evidence for falls prevention among older people in the community setting, although most is from Western countries. Differences between countries (eg sunlight exposure, diet, environment, exercise preferences) may influence the success of implementing falls prevention approaches in Asian countries that have been shown to be effective elsewhere in the world. The aim of this review is to evaluate the scope and effectiveness of falls prevention randomized controlled trials (RCTs) from the Asian region...
January 5, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29299876/the-incidence-of-injury-in-amateur-male-rugby-union-a-systematic-review-and-meta-analysis
#11
REVIEW
Caithriona Yeomans, Ian C Kenny, Roisin Cahalan, Giles D Warrington, Andrew J Harrison, Kevin Hayes, Mark Lyons, Mark J Campbell, Thomas M Comyns
BACKGROUND: Rugby union is a physically demanding, full-contact team sport that has gained worldwide popularity. The incidence of injury in rugby union has been widely reported in the literature. While comprehensive injury surveillance and prevention programmes have been implemented within the professional game, there is a need for similar strategies in the amateur game. Despite recent increases in the volume of research in rugby, there is little consensus regarding the true incidence rate of match and training injuries in senior amateur male rugby union players...
January 3, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29290940/lysophosphatidylcholine-induces-cytotoxicity-apoptosis-and-il-8-production-of-human-endothelial-cells-related-mechanisms
#12
Mei-Chi Chang, Jang-Jaer Lee, Yi-Jane Chen, Szu-I Lin, Li-Deh Lin, Eric Jein-Wen Liou, Wei-Ling Huang, Chiu-Po Chan, Chi-Chia Huang, Jiiang-Huei Jeng
Increased levels of oxidized low-density lipoprotein oxLDL) are shown to elevate the risk of cardiovascular diseases such as atherosclerosis, thrombosis, stroke, and myocardial infarction. This is possibly due to the toxic effects of oxLDLs on vascular cells. Various oxLDLs including lysophosphatidylcholine (LPC) and 7-ketocholesterol injure vascular endothelial cells and stimulate inflammatory reaction. However the toxicity of LPC on endothelial cells is not clear. In this study, human endothelial cells were exposed to LPC...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29289497/monitoring-loads-and-non-contact-injury-during-the-transition-from-club-to-national-team-prior-to-an-international-football-tournament-a-case-study-of-the-2014-fifa-world-cup-and-2015-asia-cup
#13
Alan McCall, Mark Jones, Les Gelis, Craig Duncan, Fabian Ehrmann, Gregory Dupont, Rob Duffield
OBJECTIVES: Injured and non-injured national team footballers were compared for external and internal loads during transition from club to National team training camp. DESIGN: Prospective Case Study. METHODS: Load and injury data were collected from the same National team prior to and during training camps of 2 tournaments; World (n=17) and Asian Cups (n=16). External (number sessions) and internal (s-RPE) loads were collected 4-weeks prior to and during camps...
December 20, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29288304/essential-oils-of-origanum-compactum-and-thymus-vulgaris-exert-a-protective-effect-against-the-phytopathogen-allorhizobium-vitis
#14
Khaoula Habbadi, Thibault Meyer, Ludovic Vial, Vincent Gaillard, Rachid Benkirane, Abdellatif Benbouazza, Isabelle Kerzaon, El Hassan Achbani, Céline Lavire
Allorhizobium (Agrobacterium) vitis is a host-specific pathogenic bacterium that causes grapevine crown gall disease, affecting vine growth and production worldwide. The antibacterial activities of different aromatic plant essential oils were tested in vitro and in planta against A. vitis. Among the essential oils tested, those of Origanum compactum and Thymus vulgaris showed the most significant in vitro antibacterial activities, with a MIC of 0.156 and 0.312 mg/mL, respectively. A synergistic effect of these two essential oils (1:1) was observed and confirmed by the checkerboard test...
December 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29286452/esophageal-heat-transfer-for-patient-temperature-control-and-targeted-temperature-management
#15
Melissa I Naiman, Maria Gray, Joseph Haymore, Ahmed F Hegazy, Andrej Markota, Neeraj Badjatia, Erik B Kulstad
Controlling patient temperature is important for a wide variety of clinical conditions. Cooling to normal or below normal body temperature is often performed for neuroprotection after ischemic insult (e.g. hemorrhagic stroke, subarachnoid hemorrhage, cardiac arrest, or other hypoxic injury). Cooling from febrile states treats fever and reduces the negative effects of hyperthermia on injured neurons. Patients are warmed in the operating room to prevent inadvertent perioperative hypothermia, which is known to cause increased blood loss, wound infections, and myocardial injury, while also prolonging recovery time...
November 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29285980/xenon-protects-against-blast-induced-traumatic-brain-injury-in-an-i-in-vitro-i-model
#16
Rita Campos-Pires, Mariia Koziakova, Amina Yonis, Ashni Pau, Warren Macdonald, Katie Harris, Christopher Edge, Nicholas P Franks, Peter Mahoney, Robert Dickinson
The aim of this study was to evaluate the neuroprotective efficacy of the inert gas xenon as a treatment for blast-induced traumatic brain injury in an in vitro laboratory model. We developed a novel blast traumatic brain injury model using C57BL/6N mouse organotypic hippocampal brain-slice cultures exposed to a single shockwave, with the resulting injury quantified using propidium iodide fluorescence. A shock tube blast generator was used to simulate open field explosive blast shockwaves, modeled by the Friedlander waveform...
December 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29285976/partial-recovery-of-proprioception-in-rats-with-dorsal-root-injury-following-human-olfactory-bulb-cell-transplantation
#17
Andrew Collins, Daqing Li, Modinat Liadi, Pawel Tabakow, Wojciech Fortuna, Geoffrey Raisman, Ying Li
We transplanted human olfactory bulb OECs (hOECs) mixed with collagen into a unilateral transection of four dorsal roots (C6-T1) in a rat model. By mixing with collagen, we could maximise the limited numbers of hOEC from an olfactory bulb biopsy and optimise cavity-filling. Cyclosporine was administered daily to prevent immune rejection. Forelimb proprioception was assessed weekly in a vertical climb task. Half of the rats receiving hOEC transplants showed some functional improvement ('responders') over six weeks of the study whilst the other half did not ('non-responders') and performed similarly to 'injured only' rats...
December 29, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29285175/quercetin-prevents-alcohol-induced-liver-injury-through-targeting-of-pi3k-akt-nuclear-factor-%C3%AE%C2%BAb-and-stat3-signaling-pathway
#18
Minglin Zhu, Xuefeng Zhou, Jinping Zhao
Quercetin is a type of flavonoid compound, which has potent antioxidant and anti-inflammatory activities, capable of treating a variety of diseases including neurodegenerative diseases, tumors, diabetes and obesity. The present study selected alcohol-induced liver injury model mice and aimed at studying the protective role of quercetin in preventing alcohol-induced liver injury. In alcohol-induced liver injury mice treated with quercetin, it was demonstrated that levels of aspartate transaminase, alanine transaminase, total bilirubin and triglyceride were reduced...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284502/reciprocal-interactions-between-prostaglandin-e2-and-estradiol-dependent-signaling-pathways-in-the-injured-zebra-finch-brain
#19
Alyssa L Pedersen, Colin J Saldanha
BACKGROUND: Astrocytic aromatization and consequent increases in estradiol are neuroprotective in the injured brain. In zebra finches, cyclooxygenase-activity is necessary for injury-induced aromatase expression, and increased central estradiol lowers neuroinflammation. The mechanisms underlying these influences are unknown. Here, we document injury-induced, cyclooxygenase-dependent increases in glial aromatase expression and replicate previous work in our lab showing increases in central prostaglandin E2 and estradiol following brain damage...
December 29, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29283933/a-preventive-model-for-muscle-injuries-a-novel-approach-based-on-learning-algorithms
#20
Alejandro López-Valenciano, Francisco Ayala, José Miguel Puerta, Mark De Ste Croix, Francisco Vera-García, Sergio Hernández-Sánchez, Iñaki Ruiz-Pérez, Gregory Myer
INTRODUCTION: The application of contemporary statistical approaches coming from Machine Learning and Data Mining environments to build more robust predictive models to identify athletes at high risk of injury might support injury prevention strategies of the future. PURPOSE: The purpose was to analyse and compare the behaviour of numerous machine learning methods in order to select the best performing injury risk factor model to identify athlete at risk of lower extremity muscle injuries (MUSINJ)...
December 28, 2017: Medicine and Science in Sports and Exercise
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