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https://www.readbyqxmd.com/read/28920076/falling-upward-with-parkinson-s-disease
#1
REVIEW
Stephen A Buetow, Pablo Martínez-Martín, Brendan McCormack
Falls can injure, even kill. No one with Parkinson's disease (PD) wants to fall by accident. However, the potential nastiness of falls does not preclude a more nuanced understanding of the personal meaning that falls can have. Rather than view falls as a problem to fear and manage solely by preventing and repairing harm, people with PD and those who care for them may recast falls as a mixed blessing. Falls may be a resource, skill, and catalyst for personal growth. We discuss how falls may give rise to opportunities in interrelated domains: capabilities, credo, character, creativity, chronemics, and connectedness...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28919738/surface-modification-of-endovascular-stents-with-rosuvastatin-and-heparin-loaded-biodegradable-nanofibers-by-electrospinning
#2
Milka Janjic, Foteini Pappa, Varvara Karagkiozaki, Christakis Gitas, Kiriakos Ktenidis, Stergios Logothetidis
This study describes the development of drug-loaded nanofibrous scaffolds as a nanocoating for endovascular stents for the local and sustained delivery of rosuvastatin (Ros) and heparin (Hep) to injured artery walls after endovascular procedures via the electrospinning process. PURPOSE: The proposed hybrid covered stents can promote re-endothelialization; improve endothelial function; reduce inflammatory reaction; inhibit neointimal hyperplasia of the injured artery wall, due to well-known pleiotropic actions of Ros; and prevent adverse events such as in-stent restenosis (ISR) and stent thrombosis (ST), through the antithrombotic action of Hep...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28919185/epidemiology-of-cervical-spine-injuries-in-high-school-athletes-over-a-ten-year-period
#3
Adele Meron, Christopher McMullen, Scott R Laker, Dustin Currie, R Dawn Comstock
BACKGROUND: Over 7 million athletes participate in high school (HS) sports annually, with both the benefits of physical activity and risks of injury. While catastrophic cervical spine injuries have been studied, limited data are available characterizing less severe cervical spine injuries in HS athletes. OBJECTIVE: To describe and compare cervical spine injury rates and patterns among United States (US) HS athletes across 24 sports over a ten-year period. DESIGN: Descriptive epidemiology study SETTING: National sample of high schools participating in the High School Reporting Information Online (High School RIO) injury surveillance system...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28919111/promethazine-hydrochloride-inhibits-ectopic-fat-cell-formation-in-skeletal-muscle
#4
Takehiro Kasai, Masashi Nakatani, Naoki Ishiguro, Kinji Ohno, Naoki Yamamoto, Mitsuhiro Morita, Harumoto Yamada, Kunihiro Tsuchida, Akiyoshi Uezumi
Fatty degeneration of skeletal muscle leads to muscle weakness and loss of function. Preventing fatty degeneration in skeletal muscle is important, but no drug has been used clinically. In this study, we performed drug repositioning using human platelet-derived growth factor receptor α (PDGFRα)-positive mesenchymal progenitors that have been proved to be an origin of ectopic adipocytes in skeletal muscle. We found that promethazine hydrochloride (PH) inhibits adipogenesis in a dose-dependent manner without cell toxicity...
September 14, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28913340/caregiver-reports-of-interactions-between-children-up-to-6-years-and-their-family-dog-implications-for-dog-bite-prevention
#5
Christine Arhant, Andrea Martina Beetz, Josef Troxler
In children up to 6 years, interactions such as interfering with the dog's resources and also benign behaviors (e.g., petting) commonly precede a bite incident with the family dog. Therefore, the aim of the present study was to explore the development of everyday interactions between children up to 6 years and their family dogs and whether parents' attitudes to supervision are related to those interactions. Additionally, we investigated whether behavior of dogs that had lived in the family for longer than the child differed from those that grew up with children...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28912882/atorvastatin-alleviates-iodinated-contrast-media-induced-cytotoxicity-in-human-proximal-renal-tubular-epithelial-cells
#6
Gai-Ling Liu, Rong Lei, Shao-Bin Duan, Mi-Mi Tang, Min Luo, Qian Xu
Contrast media (CM)-induced nephropathy (CIN) is a serious complication of intravascularly applied radiocontrast media. At present, no drugs have been approved for the prevention of CIN. The present study aimed to explore the effects and potential mechanisms of atorvastatin on iodinated CM-induced cytotoxicity in the human proximal renal tubular epithelial cells. The cytotoxic effect of iohexol (50, 100 and 200 mg I/ml) and the protective effect of atorvastatin pretreatment (1, 20 and 40 µM) were assessed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912731/long-term-athletic-development-in-youth-alpine-ski-racing-the-effect-of-physical-fitness-ski-racing-technique-anthropometrics-and-biological-maturity-status-on-injuries
#7
Lisa Müller, Carolin Hildebrandt, Erich Müller, Christian Fink, Christian Raschner
Alpine ski racing is known to be a sport with a high risk of injuries. Because most studies have focused mainly on top-level athletes and on traumatic injuries, limited research exists about injury risk factors among youth ski racers. The aim of this study was to determine the intrinsic risk factors (anthropometrics, biological maturity, physical fitness, racing technique) for injury among youth alpine ski racers. Study participants were 81 youth ski racers attending a ski boarding school (50 males, 31 females; 9-14 years)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28912364/novel-pathological-role-of-hnrnpa1-heterogeneous-nuclear-ribonucleoprotein-a1-in-vascular-smooth-muscle-cell-function-and-neointima-hyperplasia
#8
Li Zhang, Qishan Chen, Weiwei An, Feng Yang, Eithne Margaret Maguire, Dan Chen, Cheng Zhang, Guanmei Wen, Mei Yang, Bin Dai, Le Anh Luong, Jianhua Zhu, Qingbo Xu, Qingzhong Xiao
OBJECTIVE: hnRNPA1 (heterogeneous nuclear ribonucleoprotein A1) plays a variety of roles in gene expression. However, little is known about the functional involvement of hnRNPA1 in vascular smooth muscle cell (VSMC) function and neointima hyperplasia. In this study, we have attempted to investigate the functional roles of hnRNPA1 in the contexts of VSMC function, injury-induced vessel remodeling, and human atherosclerotic lesions, as well as discern the molecular mechanisms involved. APPROACH AND RESULTS: hnRNPA1 expression levels were consistently modulated during VSMC phenotype switching and neointimal lesion formation induced by wire injury...
September 14, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28910936/-current-status-and-change-trend-of-violence-against-children-in-china-from-2006-to-2015-an-analysis-on-data-from-national-injury-surveillance-system
#9
L Yang, X Gao, Y Jin, P P Ye, Y Wang, X Deng, Y L Er, T Shen, L L Duan
Objective: To understand the current status and change trend of violence against children in China and provide evidence for the risk factor and intervention priority identifications and intervention strategy development. Methods: The data of National Injury Surveillance System (NISS) from 2006 to 2015 were used to analyze the change in outpatient visit due to violence against children, injury cases'demographic characteristics, incidence of injury and clinical outcomes of injury cases. Results: A total of 44 319 injury cases caused by violence against children were reported through NISS during this period...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28906302/chemotherapy-extravasation-management-21-year-experience
#10
Maria Giuseppina Onesti, Sara Carella, Paolo Fioramonti, Nicolò Scuderi
Chemotherapy extravasation may result in serious damage to patients, with irreversible local injures and disability. Evidence-based standardization on extravasation management is lacking and many institutions do not practice adequate procedures to prevent the severer damages. Our aim was to explore the prevention and treatment of extravasation injuries, proposing a standard therapeutic protocol together with a review of the literature. From January 1994 to December 2015, 545 cases were reviewed (age range, 5-87 years; 282 men and 263 women)...
September 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28901303/role-of-collagen-triple-helix-repeat-containing-1-in-tumor-and-inflammatory-diseases
#11
REVIEW
Qian Wu, Qingrui Yang, Hongsheng Sun
Initially, collagen triple helix repeat containing-1 (CTHRC1) is expressed mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels, and increases cell migration, promotes tissue repair in response to injury. A variety of studies demonstrated that over-expression of CTHRC1 in solid tumors results in enhancement of migration and invasion of tumor cells, and is associated with decreased overall survival and disease-free survival. CTHRC1 expression is elevated in hepatitis B virus-infected patients and highly correlated with hepatocellular carcinoma progression as well...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#12
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28894756/relationships-between-tibiofemoral-contact-forces-and-cartilage-morphology-at-2-to-3-years-after-single-bundle-hamstring-anterior-cruciate-ligament-reconstruction-and-in-healthy-knees
#13
David John Saxby, Adam L Bryant, Xinyang Wang, Luca Modenese, Pauline Gerus, Jason M Konrath, Kim L Bennell, Karine Fortin, Tim Wrigley, Flavia M Cicuttini, Christopher J Vertullo, Julian A Feller, Tim Whitehead, Price Gallie, David G Lloyd
BACKGROUND: Prevention of knee osteoarthritis (OA) following anterior cruciate ligament (ACL) rupture and reconstruction is vital. Risk of postreconstruction knee OA is markedly increased by concurrent meniscal injury. It is unclear whether reconstruction results in normal relationships between tibiofemoral contact forces and cartilage morphology and whether meniscal injury modulates these relationships. HYPOTHESES: Since patients with isolated reconstructions (ie, without meniscal injury) are at lower risk for knee OA, we predicted that relationships between tibiofemoral contact forces and cartilage morphology would be similar to those of normal, healthy knees 2 to 3 years postreconstruction...
August 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28888901/oral-administration-of-undenatured-native-chicken-type-ii-collagen-uc-ii-diminished-deterioration-of-articular-cartilage-in-a-rat-model-of-oa
#14
Cedo M Bagi, Edwin R Berryman, Steve Teo, Nancy E Lane
OBJECTIVE: The aim of this study was to determine the ability of undenatured native chicken type II collagen (UC-II) to prevent excessive articular cartilage deterioration in a rat model of osteoarthritis (OA). METHODS: Twenty male rats were subjected to partial medial meniscectomy tear (PMMT) surgery to induce OA. Immediately after the surgery ten rats received vehicle and another ten rats oral daily dose of UC-II at 0.66 mg/kg for a period of 8 weeks. In addition ten naïve rats were used as an intact control and another 10 rats received sham surgery...
September 6, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28887987/in-situ-cross-linking-carbodiimide-modified-chitosan-hydrogel-for-postoperative-adhesion-prevention-in-a-rat-model
#15
Long-Xiang Lin, Jing-Wan Luo, Fang Yuan, Hui-Hui Zhang, Chen-Qing Ye, Peng Zhang, Yu-Long Sun
BACKGROUND: Postoperative intra-abdominal adhesion often causes many complications. Chitosan fluid has been used in clinic to prevent intra-abdominal adhesion. However, fluid can be easily diluted and cannot stay on the wound site. As hydrogel is able to form stable physical barrier to separate injured tissues, we developed a chitosan hydrogel for better prevention of intra-abdominal adhesion in this study. METHODS: We synthesized a carbodiimide-derivatized chitosan gelatin (cd-CS-gelatin) hydrogel and investigated its rheological properties...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28883614/an-optical-probe-for-detecting-chondrocyte-apoptosis-in-response-to-mechanical-injury
#16
Yihui Huang, Jun Zhou, Amirhossein Hakamivala, Jinglei Wu, Yi Hong, Joseph Borrelli, Liping Tang
Cartilage injury induced by acute excessive contact stress is common and mostly affects young adult. Although early detection of cartilage injury may prevent serious and lifelong arthritic complications, early detection and treatment is not possible due to the lack of a reliable detection method. Since chondrocyte injury and subsequent cell death are the early signs of cartilage injury, it is likely that cartilage cell apoptosis can be used to predict the extent of injury. To test this hypothesis, a near infrared probe was fabricated to have high affinity to apoptotic cells...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878711/parental-factors-associated-with-child-post-traumatic-stress-following-injury-a-consideration-of-intervention-targets
#17
REVIEW
Anna E Wise, Douglas L Delahanty
Post-traumatic stress disorder (PTSD) symptoms are relatively common following pediatric traumatic injury and are related to poor long-term child outcomes. However, due to concerns regarding the efficacy of early child preventive interventions, and difficulty intervening with injured and medicated children soon after the event, it is not feasible to provide early psychological interventions to children exposed to traumatic injury. Parental PTSD symptoms and reactions to the child's traumatic injury impact child outcomes and provide potential targets for early intervention to reduce child symptom development without involving the child...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28874967/behavior-of-injured-lamina-in-lumbar-burst-fractures-during-reduction-maneuvers-a-biomechanical-study
#18
Nihat Acar
STUDY DESIGN: An experimental biomechanical study. PURPOSE: This study aims to investigate the behavior of a lamina injury in lumbar burst fractures during reduction maneuvers. OVERVIEW OF LITERATURE: Lumbar burst fractures are frequently accompanied by a lamina fracture. Many researchers concluded that any reduction maneuver will close the fractured lamina edges and possibly crush the entrapped neural elements. This conclusion did not rely on solid biomechanical trials and was based primarily on clinical experience...
August 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28874746/rgma-inhibition-with-human-monoclonal-antibodies-promotes-regeneration-plasticity-and-repair-and-attenuates-neuropathic-pain-after-spinal-cord-injury
#19
Andrea J Mothe, Nardos G Tassew, Alirezha P Shabanzadeh, Romeo Penheiro, Robin J Vigouroux, Lili Huang, Christine Grinnell, Yi-Fang Cui, Emma Fung, Philippe P Monnier, Bernhard K Mueller, Charles H Tator
Traumatic spinal cord injury (SCI) causes a cascade of degenerative events including cell death, axonal damage, and the upregulation of inhibitory molecules which prevent regeneration and limit recovery. Repulsive guidance molecule A (RGMa) is a potent neurite growth inhibitor in the central nervous system, exerting its repulsive activity by binding the Neogenin receptor. Here, we show for the first time that inhibitory RGMa is markedly upregulated in multiple cell types after clinically relevant impact-compression SCI in rats, and importantly, also in the injured human spinal cord...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874604/mitochondrial-redox-signaling-enables-repair-of-injured-skeletal-muscle-cells
#20
Adam Horn, Jack H Van der Meulen, Aurelia Defour, Marshall Hogarth, Sen Chandra Sreetama, Aaron Reed, Luana Scheffer, Navdeep S Chandel, Jyoti K Jaiswal
Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers, injures their plasma membranes, and mitochondrial function is required for their repair. We found that mitochondrial function was also needed for plasma membrane repair in myoblasts as well as nonmuscle cells, which depended on mitochondrial uptake of calcium through the mitochondrial calcium uniporter (MCU). Calcium uptake transiently increased the mitochondrial production of reactive oxygen species (ROS), which locally activated the guanosine triphosphatase (GTPase) RhoA, triggering F-actin accumulation at the site of injury and facilitating membrane repair...
September 5, 2017: Science Signaling
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