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Cervical spinal cord injury

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https://www.readbyqxmd.com/read/28212662/marked-central-nervous-system-pathology-in-cd59-knockout-rats-following-passive-transfer-of-neuromyelitis-optica-immunoglobulin-g
#1
Xiaoming Yao, Alan S Verkman
Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies targeting aquaporin-4 (AQP4-IgG) on astrocytes. We reported evidence previously, using CD59(-/-) mice, that the membrane-associated complement inhibitor CD59 modulates CDC in NMO (Zhang and Verkman, J. Autoimmun. 53:67-77, 2014). Motivated by the observation that rats, unlike mice, have human-like complement activity, here we generated CD59(-/-) rats to investigate the role of CD59 in NMO and to create NMO pathology by passive transfer of AQP4-IgG under conditions in which minimal pathology is produced in normal rats...
February 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28199829/preclinical-efficacy-failure-of-human-cns-derived-stem-cells-for-use-in-the-pathway-study-of%C3%A2-cervical-spinal-cord-injury
#2
Aileen J Anderson, Katja M Piltti, Mitra J Hooshmand, Rebecca A Nishi, Brian J Cummings
We previously showed the efficacy of multiple research cell lines (RCLs) of human CNS neural stem cells (HuCNS-SCs) in mouse and rat models of thoracic spinal cord injury (SCI), supporting a thoracic SCI clinical trial. Experts recommend in vivo preclinical testing of the intended clinical cell lot/line (CCL) in models with validity for the planned clinical target. We therefore tested the efficacy of two HuCNS-SC lines in cervical SCI: one RCL, and one CCL intended for use in the Pathway Study of cervical SCI in man...
February 14, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28198660/prediction-of-functional-recovery-six-months-following-traumatic-spinal-cord-injury-during-acute-care-hospitalization
#3
Andréane Richard-Denis, Debbie Feldman, Cynthia Thompson, Jean-Marc Mac-Thiong
OBJECTIVES: To determine factors associated with functional status six months following a traumatic cervical and thoracic spinal cord injury (SCI), with a particular interest in factors related to the acute care hospitalization stay. DESIGN: This is a prospective cohort study. Sixteen potential predictive variables were studied. Univariate regression analyses were first performed to determine the strength of association of each variable independently with the total Spinal Cord Independence Measure (SCIM) score...
February 15, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28195230/epidemiology-of-traumatic-spinal-cord-injury-in-galicia-spain-trends-over-a-20-year-period
#4
A Montoto-Marqués, M E Ferreiro-Velasco, S Salvador-de la Barrera, V Balboa-Barreiro, A Rodriguez-Sotillo, R Meijide-Failde
STUDY DESIGN: Observational study with prospective and retrospective monitoring. OBJECTIVE: To describe the epidemiological and demographic characteristics of traumatic spinal cord injury (TSCI), and to analyze its epidemiological changes. SETTING: Unidad de Lesionados Medulares, Complejo Hospitalario Universitario A Coruña, in Galicia (Spain). METHODS: The study included patients with TSCI who had been hospitalized between January 1995 and December 2014...
February 14, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28192830/thermoregulatory-responses-during-competitive-wheelchair-rugby-match-play
#5
Katy E Griggs, George Havenith, Michael J Price, Barry S Mason, Victoria L Goosey-Tolfrey
The purpose of this study was to determine whether a player's physical impairment or activity profile was related to the amount of thermal strain experienced during wheelchair rugby match play. 17 elite wheelchair rugby players played a competitive match, whilst activity profiles, measures of core and skin temperature, heart rate and perceptual responses were taken. Players were divided into 2 groups depending on their physical impairment: players with a cervical spinal cord injury, (n=10) or non-spinal related physical impairment (n=7)...
February 13, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28192079/electrical-neuromodulation-of-the-cervical-spinal-cord-facilitates-forelimb-skilled-function-recovery-in-spinal-cord-injured-rats
#6
Monzurul Alam, Guillermo Garcia-Alias, Benita Jin, Jonathan Keyes, Hui Zhong, Roland R Roy, Yury Gerasimenko, Daniel C Lu, V Reggie Edgerton
Enabling motor control by epidural electrical stimulation of the spinal cord is a promising therapeutic technique for the recovery of motor function after a spinal cord injury (SCI). Although epidural electrical stimulation has resulted in improvement in hindlimb motor function, it is unknown whether it has any therapeutic benefit for improving forelimb fine motor function after a cervical SCI. We tested whether trains of pulses delivered at spinal cord segments C6 and C8 would facilitate the recovery of forelimb fine motor control after a cervical SCI in rats...
February 9, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28187803/management-of-acute-traumatic-spinal-cord-injuries
#7
C D Shank, B C Walters, M N Hadley
Acute traumatic spinal cord injury (SCI) is a devastating disease process affecting tens of thousands of people across the USA each year. Despite the increase in primary prevention measures, such as educational programs, motor vehicle speed limits, automobile running lights, and safety technology that includes automobile passive restraint systems and airbags, SCIs continue to carry substantial permanent morbidity and mortality. Medical measures implemented following the initial injury are designed to limit secondary insult to the spinal cord and to stabilize the spinal column in an attempt to decrease devastating sequelae...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28175426/179%C3%A2-chemogenetic-stimulation-of-the-lumbar-locomotor-network-enhances-motor-function-following-experimental-cervical-spinal-cord-injury-translational-relevance-for-a-novel-therapeutic-strategy
#8
Spyridon K Karadimas, Kajana Satkunendrarajah, Michael G Fehlings
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28175418/168%C3%A2-impact-of-initial-clinical-and-imaging-parameters-on-long-term-neurological-outcomes-in-acute-traumatic-cervical-spinal-cord-injury
#9
Sunil Kukreja, Jan Schwab, Francis Farhadi
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28169954/nerve-root-compression-increases-spinal-astrocytic-vimentin-in-parallel-with-sustained-pain-and-endothelial-vimentin-in-association-with-spinal-vascular-reestablishment
#10
Jenell R Smith, Jasmine Lee, Beth A Winkelstein
STUDY DESIGN: Temporal immunohistochemistry analysis of spinal cord tissue from a rat model of cervical radiculopathy. OBJECTIVE: The goal was to measure spinal endothelial and astrocytic vimentin expression following a painful nerve root compression to define spinal cellular expression of vimentin in the context of pain. SUMMARY OF BACKGROUND DATA: The intermediate filament, vimentin, is expressed in a variety of cell types in the spinal cord and is modulated in response to neural pathologies...
February 6, 2017: Spine
https://www.readbyqxmd.com/read/28169354/three-dimensional-aligned-nanofibers-hydrogel-scaffold-for-controlled-non-viral-drug-gene-delivery-to-direct-axon-regeneration-in-spinal-cord-injury-treatment
#11
Lan Huong Nguyen, Mingyong Gao, Junquan Lin, Wutian Wu, Jun Wang, Sing Yian Chew
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in axon regeneration. Unfortunately, currently established treatments, such as direct drug administration, do not effectively treat SCI due to rapid drug clearance from our bodies. Here, we introduce a three-dimensional aligned nanofibers-hydrogel scaffold as a bio-functionalized platform to provide sustained non-viral delivery of proteins and nucleic acid therapeutics (small non-coding RNAs), along with synergistic contact guidance for nerve injury treatment...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28152039/individualized-3d-printing-navigation-template-for-pedicle-screw-fixation-in-upper-cervical-spine
#12
Fei Guo, Jianhao Dai, Junxiang Zhang, Yichuan Ma, Guanghui Zhu, Junjie Shen, Guoqi Niu
PURPOSE: Pedicle screw fixation in the upper cervical spine is a difficult and high-risk procedure. The screw is difficult to place rapidly and accurately, and can lead to serious injury of spinal cord or vertebral artery. The aim of this study was to design an individualized 3D printing navigation template for pedicle screw fixation in the upper cervical spine. METHODS: Using CT thin slices data, we employed computer software to design the navigation template for pedicle screw fixation in the upper cervical spine (atlas and axis)...
2017: PloS One
https://www.readbyqxmd.com/read/28132610/upper-limb-recovery-in-spinal-cord-injury
#13
Jens A Petersen, Martina Spiess, Armin Curt, Norbert Weidner, Rüdiger Rupp, Rainer Abel, Martin Schubert
BACKGROUND AND OBJECTIVE: The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS: Compound motor action potentials (CMAPs), motor-evoked potentials (MEPs), and F-waves were recorded from the abductor digiti minimi and CMAP and F-waves from abductor hallucis muscles in 305 patients at about 15 days, 1 month, 3 months, 6 months, and 12 months following an acute traumatic SCI...
January 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28130472/long-term-functional-outcome-in-patients-with-acquired-infections-after-acute-spinal-cord-injury
#14
Marcel A Kopp, Ralf Watzlawick, Peter Martus, Vieri Failli, Felix W Finkenstaedt, Yuying Chen, Michael J DeVivo, Ulrich Dirnagl, Jan M Schwab
OBJECTIVE: To investigate whether prevalent hospital-acquired pneumonia and wound infection affect the clinical long-term outcome after acute traumatic spinal cord injury (SCI). METHODS: This was a longitudinal cohort study within the prospective multicenter National Spinal Cord Injury Database (Birmingham, Alabama). We screened datasets of 3,834 patients enrolled in 20 trial centers from 1995 to 2005 followed up until 2016. Eligibility criteria were cervical SCI and American Spinal Cord Injury Association impairment scale A, B, and C...
January 27, 2017: Neurology
https://www.readbyqxmd.com/read/28128063/tonic-and-rhythmic-spinal-activity-underlying-locomotion
#15
Yury P Ivanenko, Victor S Gurfinkel, Victor A Selionov, Irina A Solopova, Francesca Sylos-Labini, Pierre A Guertin, Francesco Lacquaniti
In recent years, many researches put significant efforts into understanding and assessing the functional state of the spinal locomotor circuits in humans. Various techniques have been developed to stimulate the spinal cord circuitries, which may include both diffuse and quite specific tuning effects. Overall, the findings indicate that tonic and rhythmic spinal activity control are not separate phenomena but are closely integrated to properly initiate and sustain stepping. The spinal cord does not simply transmit information to and from the brain...
January 25, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28125929/trans-synaptic-degeneration-of-motoneurons-distal-to-chronic-cervical-spinal-cord-compression-in-cervical-spondylotic-myelopathy
#16
Chaojun Zheng, Yu Zhu, Feizhou Lu, Xiaosheng Ma, Dong Tian, Jianyuan Jiang
OBJECTIVE: To assess the effect of chronic cervical spinal cord compression upon remote motor unit function in patients with cervical spondylotic myelopathy (CSM). METHODS: Fifty-three CSM patients and 47 healthy subjects were included. Bilateral motor unit number estimations (MUNEs) were recorded from both abductor digiti minimi and abductor pollicis brevis, and bilateral flexor carpi radialis (FCR) H-reflexes were examined in all subjects along with the nine-hole peg test (NHPT)...
January 26, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28125522/post-traumatic-spinal-hygroma-causing-cord-compression-in-type-iii-odontoid-fracture-with-vertical-atlanto-axial-instability
#17
Salvatore Russo, Antonio Belli, Andy Eynon, Ali Nader-Sepahi
STUDY DESIGN: Case-Report OBJECTIVE.: To report the first case in the literature of a traumatic cervical spine subdural cerebrospinal fluid (CSF) collection (hygroma) under tension causing cord compression. We suggest etio-pathogenesis and modality of treatment. SUMMARY OF BACKGROUND DATA: Hygromas are subdural cranial CSF collection. A literature review showed no previous published case of post-traumatic spinal hygroma. This was a potential life threatening sequelae of a high cervical injury that warranted early diagnosis and emergency treatment...
January 25, 2017: Spine
https://www.readbyqxmd.com/read/28120050/spinal-cord-stimulation-for-vegetative-state-and-minimally-conscious-state-changes-in-consciousness-level-and-motor-function
#18
Takamitsu Yamamoto, Mitsuru Watanabe, Toshiki Obuchi, Kazutaka Kobayashi, Hideki Oshima, Chikashi Fukaya, Atsuo Yoshino
Twenty-one vegetative state (VS) patients and 10 minimally conscious state (MCS) patients were treated by spinal cord stimulation (SCS) following an electrophysiological evaluation 3 months or more after the onset of brain injury.A flexible four-contact cylindrical electrode was inserted into the epidural space of the cervical vertebrae, and placed at cervical levels C2-C4. Five-hertz stimulation was applied for 5 min every 30 min during the daytime at an intensity that produced muscle twitches of the upper extremities...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28117330/successful-tracheostomy-decannulation-after-complete-or-sensory-incomplete-cervical-spinal-cord-injury
#19
D H Kim, S W Kang, W A Choi, H J Oh
STUDY DESIGN: Retrospective study. OBJECTIVES: To report the successful tracheostomy decannulation/extubation in cervical spinal cord injury (C-SCI) patients. SETTING: Tertiary university hospital, pulmonary rehabilitation center. METHODS: Complete or sensory incomplete C-SCI patients who had received invasive acute phase respiratory management, and succeeded in decannulation/extubation became candidates of this study...
January 24, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28114866/refractory-orthostatic-hypotension-in-a-patient-with-a-spinal-cord-injury-treatment-with-droxidopa
#20
Eva Canosa-Hermida, Cristina Mondelo-García, María Elena Ferreiro-Velasco, Sebastián Salvador-de la Barrera, Antonio Montoto-Marqués, Antonio Rodríguez-Sotillo, José Ramón Vizoso-Hermida
CONTEXT: Orthostatic hypotension (OH) is a common complication in patients with a spinal cord injury, mainly affecting complete injuries above neurological level T6. It is generally more severe during the acute phase but can remain symptomatic for several years. FINDINGS: A 65-year-old male with a grade ASIA A post-traumatic cervical spinal cord injury, at neurological level C4, presenting with symptomatic refractory OH. Increased blood pressure (BP) levels and an overall clinical improvement was observed after administering an increasing dose of droxidopa...
January 24, 2017: Journal of Spinal Cord Medicine
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