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Cervical spinal cord injury

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https://www.readbyqxmd.com/read/28631744/traumatic-cervical-spinal-cord-injury-a-prospective-clinical-study-of-laryngeal-penetration-and-aspiration
#1
T Ihalainen, I Rinta-Kiikka, T M Luoto, E A Koskinen, A-M Korpijaakko-Huuhka, A Ronkainen
STUDY DESIGN: Prospective cohort study. OBJECTIVES: Dysphagia is a relatively common secondary complication in patients with traumatic cervical spinal cord injuries (TCSCI). The purpose of this study was to determine the incidence of aspiration and penetration in patients with acute TCSCI. SETTING: Tampere University Hospital, Tampere, Finland. METHODS: A total of 46 patients with TCSCI were evaluated with a videofluoroscopic swallowing study (VFSS)...
June 20, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28630243/quad-fever-beware-of-non-infectious-fever-in-high-spinal-cord-injuries
#2
Jyoti Goyal, Rakesh Jha, Paramjeet Bhatia, Raj Kumar Mani
A case of cervical spinal cord injury and quadriparesis with prolonged fever is being described. Initially, the patient received treatment for well-documented catheter-related bloodstream infection. High spiking fever returned and persisted with no obvious evidence of infection. The usual non-infectious causes too were carefully excluded. QUAD fever or fever due to spinal cord injury itself was considered. The pathogenetic basis of QUAD fever is unclear but could be attributed to autonomic dysfunction and temperature dysregulation...
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28628531/costs-and-length-of-stay-for-the-acute-care-of-patients-with-motor-complete-spinal-cord-injury-following-cervical-trauma-the-impact-of-early-transfer-to-specialized-acute-sci-center
#3
Andréane Richard-Denis, Debbie Ehrmann Feldman, Cynthia Thompson, Étienne Bourassa-Moreau, Jean-Marc Mac-Thiong
OBJECTIVE: Acute spinal cord injury (SCI) centers aim to optimize outcome following SCI. However, there is no timeframe to transfer patients from regional to SCI centers in order to promote cost-efficiency of acute care. Our objective was to compare costs and length of stay (LOS) following early and late transfer to the SCI center. DESIGN: A retrospective cohort study involving 116 individuals was conducted. Group 1 (n = 87) was managed in an SCI center promptly after the trauma, whereas group 2 (n = 29) was transferred to the SCI center only after surgery...
July 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28626016/the-mtor-substrate-s6-kinase-1-s6k1-is-a-negative-regulator-of-axon-regeneration-and-a-potential-drug-target-for-central-nervous-system-injury
#4
Hassan Al-Ali, Ying Ding, Tatiana Slepak, Wei Wu, Yan Sun, Yania Martinez, Xiao-Ming Xu, V P Lemmon, J L Bixby
The mammalian target of Rapamycin (mTOR) positively regulates axon growth in the mammalian central nervous system (CNS). Though axon regeneration and functional recovery from CNS injuries are typically limited, knockdown or deletion of PTEN, a negative regulator of mTOR, increases mTOR activity and induces robust axon growth and regeneration. It has been suggested that inhibition of S6 Kinase 1 (S6K1, gene symbol: RPS6KB1), a prominent mTOR target, would blunt mTOR's positive effect on axon growth. In contrast to this expectation, we demonstrate that inhibition of S6K1 in CNS neurons promotes neurite outgrowth in vitro by 2-3 fold...
June 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28622486/the-physiological-basis-of-cervical-facet-mediated-persistent-pain-basic-science-and-clinical-challenges
#5
Meagan E Ita, Sijia Zhang, Timothy P Holsgrove, Sonia Kartha, Beth A Winkelstein
Synopsis Chronic neck pain is common and a primary clinical symptom of whiplash and other spinal injuries. Loading-induced neck injuries produce abnormal kinematics between the vertebrae, with the potential to injure facet joints and the afferent fibers that innervate the specific joint tissues, including the capsular ligament. Mechanoreceptive and nociceptive afferents that innervate the facet have their peripheral terminals in the capsule, cell bodies in the dorsal root ganglia, and terminal processes in the spinal cord...
June 16, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28615341/high-frequency-epidural-stimulation-across-the-respiratory-cycle-evokes-phrenic-short-term-potentiation-after-incomplete-cervical-spinal-cord-injury
#6
Elisa J Gonzalez-Rothi, Kristi A Streeter, Marie H Hanna, Anna C Stamas, Paul J Reier, David M Baekey, David D Fuller
C2 spinal hemilesion (C2Hx) paralyzes the ipsilateral diaphragm, but recovery is possible through activation of "crossed spinal" synaptic inputs to ipsilateral phrenic motoneurons. We tested the hypothesis that high frequency epidural stimulation (HF-ES) would potentiate ipsilateral phrenic output after subacute and chronic C2Hx. HF-ES (300 Hz) was applied to the ventrolateral C4 or T2 spinal cord ipsilateral to C2Hx in anesthetized and mechanically ventilated adult rats. Stimulus duration was 60-sec and currents ranged from 100-1000 µA...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28608179/anterior-submandibular-retropharyngeal-odontoid-osteotomy-and-posterior-atlantoaxial-fusion-for-irreducible-atlantoaxial-dislocation-associated-with-odontoid-fracture-malunion
#7
Cheng Li, Jingzhu Duan, Lei Li
PURPOSE: To report a case of complex odontoid fracture malunion accompanied by atlantoaxial dislocation which was treated with a new surgical approach. METHODS: A 53-year-old female was admitted due to progressive symptoms with a stiff limp and unsteady gait. Preoperative examination, diagnostic radiography, computed tomography, and magnetic resonance imaging were performed following admission. The examinations showed odontoid fracture malunion, an old right axial zygapophyseal fracture, atlantoaxial dislocation, and spinal cord injury...
June 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28607823/traumatic-spondyloptosis-of-the-cervical-spine-a-case-report-and-discussion-of-worldwide-treatment-trends
#8
Kelly E Wong, Peter S Chang, Mark S Monasky, Rodney M Samuelson
BACKGROUND: Cervical spondyloptosis is defined as the dislocation of the spinal column most often caused by trauma. Due to compression or transection of the spinal cord, severe neurological deficits are common. Here, we review the literature and report a case of traumatic C5-6 spondyloptosis that was successfully treated using an anterior-only surgical approach. METHODS: The patient presented with quadriplegia and absent sensation distal to the C5 dermatome following a rollover motor vehicle accident...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28605971/impaired-baroreflex-function-during-orthostatic-challenge-in-patients-after-spinal-cord-injury
#9
Katarina Ondrusova, Jana Svacinova, Michal Javorka, Jan Novak, Marie Novakova, Zuzana Novakova
The level of spinal cord injury (SCI) affects baroreflex regulation of blood pressure (BP). While a parasympathetic cardiac chronotropic effect is preserved, baroreflex response could be impaired by sympathetic dysfunction under the SCI level. This study was aimed to evaluate the baroreflex function in SCI patients by the analysis of causal interaction between systolic blood pressure (SBP) and inter-beat intervals (IBI). BP was continuously recorded in 13 cervical SCI patients (CSCI), 9 thoracic SCI (ThSCI) and 13 able-bodied controls (Con) during two phases: sitting (PS) and orthostatic challenge (PO)...
June 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28604497/potential-mechanism-for-some-post-operative-c5-palsies-an-anatomical-study
#10
Fernando Alonso, Vlad Voin, Joe Iwanaga, David Hanscom, Jens R Chapman, Rod J Oskouian, Marios Loukas, R Shane Tubbs
STUDY DESIGN: Anatomical Study. OBJECTIVE: Determine if shoulder depression (e.g., taping the shoulders) might result in C5 nerve traction and subsequent injury. SUMMARY OF BACKGROUND DATA: Postoperative C5 nerve palsy is a recognized entity that is still often enigmatic. Inferior shoulder depression is usually employed to assist with surgical visualization during cervical spine procedures. METHODS: In the supine position, ten adult fresh frozen human cadavers underwent dissection of the spinal cord and its adjacent dorsal, ventral roots and spinal nerves from C4 to T1...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28598858/effects-of-intermittent-theta-burst-stimulation-on-spasticity-after-spinal-cord-injury
#11
Raffaele Nardone, Patrick B Langthaler, Andrea Orioli, Peter Höller, Yvonne Höller, Vanessa N Frey, Francesco Brigo, Eugen Trinka
PURPOSE: Spasticity is a common disorder in patients with spinal cord injury (SCI). The aim of this study was to investigate whether intermittent theta burst stimulation (iTBS), a safe, non-invasive and well-tolerated protocol of excitatory repetitive transcranial magnetic stimulation (rTMS), is effective in modulating spasticity in SCI patients. METHODS: In this randomized, double-blind, crossover, sham-controlled study, ten subjects with incomplete cervical or thoracic SCI received 10 days of daily sessions of real or sham iTBS...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28597208/subject-specific-regional-measures-of-water-diffusion-are-associated-with-impairment-in-chronic-spinal-cord-injury
#12
Ann S Choe, Cristina L Sadowsky, Seth A Smith, Peter C M van Zijl, James J Pekar, Visar Belegu
PURPOSE: We aimed to identify non-invasive imaging parameters that can serve as biomarkers for the integrity of the spinal cord, which is paramount to neurological function. Diffusion tensor imaging (DTI) indices are sensitive to axonal and myelin damage, and have strong potential to serve as such biomarkers. However, averaging DTI indices over large regions of interest (ROIs), a common approach to analyzing the images of injured spinal cord, leads to loss of subject-specific information...
June 8, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28594515/cervical-spine-injuries-in-the-athlete
#13
Gregory D Schroeder, Alexander R Vaccaro
Cervical spine injuries are common and range from relatively minor injuries, such as cervical muscle strains, to severe, life-threatening cervical fractures with spinal cord injuries. Although cervical spine injuries are most common in athletes who participate in contact and collision sports, such as rugby and American football, they also have been reported in athletes who participate in noncontact sports, such as baseball, gymnastics, and diving. Cervical spine injuries in athletes are not necessarily the result of substantial spine trauma; some athletes have chronic conditions, such as congenital stenosis, that increase their risk for a serious cervical spine injury after even minor trauma...
February 15, 2017: Instructional Course Lectures
https://www.readbyqxmd.com/read/28592693/non-genomic-actions-of-17-%C3%AE-estradiol-restore-respiratory-neuroplasticity-in-young-ovariectomized-female-rats
#14
Brendan J Dougherty, Elizabeth S Kopp, Jyoti J Watters
Gonadal steroids modulate CNS plasticity, including phrenic long-term facilitation (pLTF), a form of spinal respiratory neuroplasticity resulting in increased phrenic nerve motor output following exposure to acute intermittent hypoxia (aIH; three 5 min episodes, 10.5% O2). Despite the importance of respiratory system neuroplasticity, and its dependence on estrogen in males, little is known about pLTF expression or mechanisms of estrogen signaling in females. Here, we tested the hypotheses that: 1) pLTF expression in young, gonadally intact female rats would be expressed during estrous cycle stages in which 17β-estradiol (E2) is naturally high (e...
June 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28592077/-clinical-effects-of-microsurgery-in-spinal-cord-anaplastic-astrocytoma
#15
L Zhang, W Q Jia, D S Kong, Z F Zhang, J Yang
Objective: To investigate the surgical outcomes and prognosis of spinal cord anaplastic astrocytoma (AA). Methods: A total of 27 consecutive patients diagnosed as spinal cord AA between January 2008 and May 2015 in Department of Neurosurgery of Beijing Tiantan Hospital were retrospectively reviewed. There were 18 males and 9 females, the mean age was (30.7±13.0) years (ranging from 5 to 52 years). The lesions were located at cervical level in 8 patients, at thoracic level in 9 patients, at cervicothoracic level in 3 patients, and at thoracolumbar level in 7 patients, the average number of vertebral was 3...
June 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28587875/the-effectiveness-of-the-anti-cd11d-treatment-is-reduced-in-rat-models-of-spinal-cord-injury-that-produce-significant-levels-of-intraspinal-hemorrhage
#16
N M Geremia, T Hryciw, F Bao, F Streijger, E Okon, J H T Lee, L C Weaver, G A Dekaban, B K Kwon, A Brown
We have previously reported that administration of a CD11d monoclonal antibody (mAb) improves recovery in a clip-compression model of SCI. In this model the CD11d mAb reduces the infiltration of activated leukocytes into the injured spinal cord (as indicated by reduced intraspinal MPO). However not all anti-inflammatory strategies have reported beneficial results, suggesting that success of the CD11d mAb treatment may depend on the type or severity of the injury. We therefore tested the CD11d mAb treatment in a rat hemi-contusion model of cervical SCI...
June 3, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28580861/factors-associated-with-upper-extremity-contractures-after-cervical-spinal-cord-injury-a-pilot-study
#17
Dustin Hardwick, Anne Bryden, Gina Kubec, Kevin Kilgore
OBJECTIVE: To examine the prevalence of joint contractures in the upper limb and association with voluntary strength, innervation status, functional status, and demographics in a convenience sample of individuals with cervical spinal cord injury to inform future prospective studies. DESIGN: Cross-sectional convenience sampled pilot study. SETTING: Department of Veterans Affairs Research Laboratory. PARTICIPANTS: Thirty-eight participants with cervical level spinal cord injury...
June 5, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28580859/isolated-spinal-cord-compression-syndrome-revealing-delayed-extensive-superficial-siderosis-of-the-central-nervous-system-secondary-to-cervical-root-avulsion
#18
Amina Nasri, Imen Kacem, Youssef Sidhom, Mouna Ben Djebara, Amina Gargouri, Riadh Gouider
CONTEXT: Cervical root avulsion secondary to traumatic plexus injury is a rare etiology of superficial siderosis (SS) of the central nervous system (CNS). We describe the case of an isolated progressive compressive myelopathy revealing this complication and discuss the pathogenesis of such a presentation, its clinical and imaging peculiarities with a literature review. FINDINGS: We report on the case of a 48-year-old man with history of left brachial plexus injury at the age of 2 years...
June 5, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28578163/efficacy-and-safety-of-urinary-catheters-with-silver-alloy-coating-in-spinal-cord-injured-patients-a-multicentric-pragmatic-randomized-controlled-trial-the-escale-trial
#19
Xavier Bonfill, David Rigau, Manuel E Fuertes, Juana M Barrera-Chacón, María L Jáuregui-Abrisqueta, Sebastian Salvador, Carolina M Alemán-Sánchez, Albert Borau, Manuel Bea-Muñoz, Begoña Hidalgo, Maria J Andrade, Juan R Espinosa, María José Martínez-Zapata
BACKGROUND: Patients with spinal cord injury (SCI) that carry indwelling urinary catheters have an increased risk of urinary tract infection (UTIs). Antiseptic Silver Alloy-Coated silicone (SAC) urinary catheters prove to be a promising intervention to reduce UTIs; however, current evidence cannot be extrapolated to spinal cord injured patients. PURPOSE: Assess the efficacy of SAC urinary catheters for preventing catheter-associated urinary tract infections (CA-UTI)...
May 31, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28578120/intraspinal-pressure-monitoring-and-extensive-duroplasty-in-the-acute-phase-of-traumatic-spinal-cord-injury-a-systematic-review
#20
REVIEW
Tykocki Tomasz, Lukasz Poniatowski, Marcin Czyz, Michael Koziara, Guy Wynne-Jones
The prognosis in cervical spinal cord injury (SCI) is poor and surgical and neuro intensive care management need further improvement. Monitoring of the intraspinal pressure (ISP) at early stage after tSCI is clinically useful. Obtaining continuous spinal cord perfusion pressure (SCPP) measurements based on the difference between mean arterial pressure (MAP) and ISP allows offering best medical and surgical treatment during this critical phase of tSCI. The optimal SCPP was found to be between 90-100mmHg and MAP of 110-130...
May 31, 2017: World Neurosurgery
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