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Cervical spinal cord injury

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https://www.readbyqxmd.com/read/28739474/traumatic-subaxial-cervical-facet-subluxation-and-dislocation-epidemiology-radiographic-analyses-and-risk-factors-for-spinal-cord-injury
#1
Ryan D Quarrington, Claire F Jones, Petar Tcherveniakov, Jillian M Clark, Simon J I Sandler, Yu Chao Lee, Shabnam Torabiardakani, John J Costi, Brian J C Freeman
BACKGROUND CONTEXT: Distractive-flexion injuries (DFIs) of the subaxial cervical spine are major contributors to spinal cord injury (SCI). Prompt assessment and early intervention of DFIs associated with SCI is crucial to optimize patient outcome; however, neurological examination of patients with subaxial cervical injury is often difficult, as patients commonly present with reduced levels of consciousness. Therefore, it is important to establish potential associations between injury epidemiology and radiographic features, and neurological involvement...
July 21, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28738759/views-of-individuals-with-spinal-cord-injury-on-the-use-of-wearable-cameras-to-monitor-upper-limb-function-in-the-home-and-community
#2
Jirapat Likitlersuang, Elizabeth R Sumitro, Pirashanth Theventhiran, Sukhvinder Kalsi-Ryan, José Zariffa
OBJECTIVE: Hand function impairment after cervical spinal cord injury (SCI) can significantly reduce independence. Unlike current hand function assessments, wearable camera systems could potentially measure functional hand usage at home, and thus benefit the development of neurorehabilitation strategies. The objective of this study was to understand the views of individuals with SCI on the use of wearable cameras to track neurorehabilitation progress and outcomes in the community. DESIGN: Questionnaires...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28735026/regulated-viral-bdnf-delivery-in-combination-with-schwann-cells-promotes-axonal-regeneration-through-capillary-alginate-hydrogels-after-spinal-cord-injury
#3
Shengwen Liu, Beatrice Sandner, Thomas Schackel, LaShae Nicholson, Abdelwahed Chtarto, Liliane Tenenbaum, Radhika Puttagunta, Rainer Müller, Norbert Weidner, Armin Blesch
Grafting of cell-seeded alginate capillary hydrogels into a spinal cord lesion site provides an axonal bridge while physically directing regenerating axonal growth in a linear pattern. However, without an additional growth stimulus, bridging axons fail to extend into the distal host spinal cord. Here we examined whether a combinatory strategy would support regeneration of descending axons across a cervical (C5) lateral hemisection lesion in the rat spinal cord. Following spinal cord transections, Schwann cell (SC)-seeded alginate hydrogels were grafted to the lesion site and AAV5 expressing brain-derived neurotrophic factor (BDNF) under control of a tetracycline-regulated promoter was injected caudally...
July 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28732686/health-conditions-impact-on-function-health-related-quality-of-life-and-life-satisfaction-following-traumatic-spinal-cord-injury-a-prospective-observational-registry-cohort-study
#4
Carly S Rivers, Nader Fallah, Vanessa K Noonan, David Gt Whitehurst, Carolyn Schwartz, Joel Finkelstein, B Catharine Craven, Karen Ethans, Colleen O'Connell, Catherine Truchon, Chester Ho, A Gary Linassi, Christine Short, Eve Tsai, Brian Drew, Henry Ahn, Marcel F Dvorak, Jérôme Paquet, Michael G Fehlings, Luc Noreau
OBJECTIVE: To analyze relationships among injury, demographic and environmental factors on function, HRQoL and life satisfaction in individuals with traumatic SCI. DESIGN: prospective observational registry cohort study SETTING: 31 acute and rehabilitation SCI centres PARTICIPANTS: Participants (N=340) from the Rick Hansen Spinal Cord Injury Registry (RHSCIR) who were prospectively recruited from 2004-2014 were included. The model cohort included 340 participants: 79...
July 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28724333/the-impact-of-acute-management-on-the-occurrence-of-medical-complications-during-the-specialized-spinal-cord-injury-acute-hospitalization-following-motor-complete-cervical-spinal-cord-injury
#5
Andréane Richard-Denis, Debbie Erhmann Feldman, Cynthia Thompson, Jean-Marc Mac-Thiong
CONTEXT/OBJECTIVE: Determine the impact of early admission and complete perioperative management in a specialized spinal cord injury (SCI) trauma center (SCI-center) on the occurrence of medical complications following tetraplegia. DESIGN: A retrospective comparative cohort study of prospectively collected data involving 116 individuals was conducted. Group 1 (N=87) was early managed in a SCI-center promptly after the trauma, whereas Group 2 (N=29) was surgically and preoperatively managed in a non-specialized (NS) center before being transferred to the SCI-center...
July 19, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28720987/management-of-post-traumatic-neglected-cervical-facet-dislocation
#6
Vinay Prabhat, Tankeshwar Boruah, Hitesh Lal, Ramesh Kumar, Ashish Dagar, Harekrushna Sahu
BACKGROUND: Post-traumatic unilateral or bilateral sub-axial cervical spine dislocations with locked facets are quite common. In developing countries like India, many patients with cervical injuries report late due to many reasons like rural backgrounds, lack of infrastructures and skilled surgeons, unawareness, poor socioeconomic status, lack of transportation to the specialized center with proper facility, etc. Early management is essential to maximize better neurological outcome. Delayed or neglected presentation makes treatment more challenging...
April 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28720407/mechanical-properties-of-the-human-spinal-cord-under-the-compressive-loading
#7
Alireza Karimi, Ahmad Shojaei, Pedram Tehrani
The spinal cord as the most complex and critical part of the human body is responsible for the transmission of both motor and sensory impulses between the body and the brain. Due to its pivotal role any types of physical injury in that disrupts its function following by shortfalls, including the minor motor and sensory malfunctions as well as complicate quadriplegia and lifelong ventilator dependency. In order to shed light on the injuries to the spinal cord, the application of the computational models to simulate the trauma impact loading to that are deemed required...
July 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28715333/wheelchair-neuroprosthesis-for-improving-dynamic-trunk-stability
#8
Kramay Patel, Matija Milosevic, Kimitaka Nakazawa, Milos R Popovic, Kei Masani
Trunk instability is a major problem for individuals with thoracic and cervical spinal cord injury. Functional electrical stimulation (FES) neuroprosthesis, a technology that uses small electrical currents to artificially contract muscles, has previously been utilized to improve trunk stability during quasistatic and dynamic sitting. The aim of this study was to develop the first powered wheelchair-based neuroprosthesis and to test its feasibility for improving trunk stability. Eleven male, able-bodied individuals participated in the feasibility study...
July 14, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28711602/contribution-of-5-ht2a-receptors-on-diaphragmatic-recovery-after-chronic-cervical-spinal-cord-injury
#9
Kun-Ze Lee, Elisa J Gonzalez-Rothi
Unilateral C2 spinal cord hemisection (C2Hx) interrupts bulbospinal respiratory pathways innervating ipsilateral phrenic motoneurons, resulting in cessation of ipsilateral diaphragm motor output. Plasticity within the spinal neural circuitry controlling the diaphragm can induce partial recovery of phrenic bursting which correlates with the time-dependent return of spinal serotonin (5-HT) immunoreactivity in the vicinity of phrenic motoneurons. The 5-HT2A receptor subtype is present on phrenic motoneurons and its expression is up-regulated after cervical spinal cord injury; however the functional role of these receptors following injury has not been clearly defined...
July 12, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28706615/novel-effects-of-traditional-wooden-toothbrush-on-bowel-motility-symptoms-in-spinal-cord-injury-patients-findings-from-a-pilot-quasi-experimental-study
#10
Ebrahim Esfandiari, Awat Feizi, Zahra Heidari, Seyed Reza Tabibian, Pooria Shaabani, Bijan Iraj, Payman Adibi, Amrollah Ebrahimi Varzaneh
BACKGROUND: The aim of this study was to investigate the therapeutic effect of traditional wooden toothbrush usage on most severe constipation, which usually occurs in spinal cord injury (SCI) patients. METHODS: In a quasi-experimental study, 61 SCI patients were selected who had injuries in different spinal levels (cervical, thoracic, and lumbar), and severe constipation from one defection in a few days to 3 weeks. They were recommended to use traditional wooden toothbrush for 5 min twice a day, after breakfast and dinner, over a 6 weeks period...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28705774/asia-a-sensory-and-motor-complete-is-not-different-than-asia-b-sensory-incomplete-motor-complete-in-gunshot-related-spinal-cord-injury
#11
Eric McCoy, Nima Eftekhary, Kenneth Nwosu, Dudley Fukunaga, Charles Liu, Kevin Rolfe
Background Context We receive a large number of spinal cord injury (SCI) patients due to penetrating gunshot wounds (GSW) at our national rehabilitation center. Though many patients are labeled American Spinal Injury Association (ASIA) B sensory incomplete due to sensory sparing, especially deep anal pressure, with purported prognostic value, we have not observed a clinical difference from ASIA A completes. We hypothesized that sensory sparing, if meaningful, should reduce the occurrence of pressure ulcers...
July 10, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28699218/impaired-corticomuscular-coherence-during-isometric-elbow-flexion-contractions-in-human-with-cervical-spinal-cord-injury
#12
Sylvain Cremoux, Jessica Tallet, Fabien Dal Maso, Eric Berton, David Amarantini
After spinal cord injury (SCI), the reorganization of the neuromuscular system leads to increased antagonist muscles' co-activation - i.e., increased antagonist vs. agonist muscles activation ratio - during voluntary contractions. Increased muscle co-activation is supposed to result from reduced cortical influences on spinal mechanisms inhibiting antagonist muscles. The assessment of the residual interactions between cortical and muscles activity with corticomuscular coherence (CMC) in participants with SCI producing different force levels may shed new lights on the regulation of muscle co-activation...
July 12, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28693584/-long-term-stability-of-stimulating-spiral-nerve-cuff-electrodes-on-human-peripheral-nerves
#13
Breanne P Christie, Max Freeberg, William D Memberg, Gilles J C Pinault, Harry A Hoyen, Dustin J Tyler, Ronald J Triolo
BACKGROUND: Electrical stimulation of the peripheral nerves has been shown to be effective in restoring sensory and motor functions in the lower and upper extremities. This neural stimulation can be applied via non-penetrating spiral nerve cuff electrodes, though minimal information has been published regarding their long-term performance for multiple years after implantation. METHODS: Since 2005, 14 human volunteers with cervical or thoracic spinal cord injuries, or upper limb amputation, were chronically implanted with a total of 50 spiral nerve cuff electrodes on 10 different nerves (mean time post-implant 6...
July 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28684744/learning-new-movements-after-paralysis-results-from-a-home-based-study
#14
Camilla Pierella, Farnaz Abdollahi, Elias Thorp, Ali Farshchiansadegh, Jessica Pedersen, Ismael Seáñez-González, Ferdinando A Mussa-Ivaldi, Maura Casadio
Body-machine interfaces (BMIs) decode upper-body motion for operating devices, such as computers and wheelchairs. We developed a low-cost portable BMI for survivors of cervical spinal cord injury and investigated it as a means to support personalized assistance and therapy within the home environment. Depending on the specific impairment of each participant, we modified the interface gains to restore a higher level of upper body mobility. The use of the BMI over one month led to increased range of motion and force at the shoulders in chronic survivors...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28683592/functional-outcomes-in-very-early-5-hours-and-early-5-24-hours-surgical-decompression-in-traumatic-cervical-spinal-cord-injury-analysis-of-neurological-improvement-from-the-austrian-spinal-cord-injury-study-ascis
#15
Georg Mattiassich, Maria Gollwitzer, Franz Gaderer, Martina Blocher, Michael Osti, Markus Lill, Reinhold Ortmaier, Thomas Haider, Wolfgang Hitzl, Herbert Resch, Stephanie Aschauer-Wallner
Our study aim was to assess the neurological outcomes of surgical decompression and stabilisation within 5 and 24 h after injury. We performed a multicentre, retrospective cohort study in adults aged 15-85 presenting cervical spinal cord injury (CSCI) at one of 6 Austrian trauma centres participating in the Austrian Spinal Cord Injury Study (ASCIS). Neurological outcomes were measured using the American Spinal Injury Association Impairment Scale (AIS) grade according to the international standards for neurological classification of spinal cord injury (ISNCSCI) form after at least 6 months of follow-up (FU)...
July 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28676786/alterations-in-localized-electrical-impedance-myography-of-biceps-brachii-muscles-paralyzed-by-spinal-cord-injury
#16
Le Li, Argyrios Stampas, Henry Shin, Xiaoyan Li, Ping Zhou
This study assessed electrical impedance myography (EIM) changes after spinal cord injury (SCI) with a localized multifrequency technology. The EIM measurement was performed on the biceps brachii muscle at rest condition of 17 cervical SCI subjects, and 23 neurologically intact subjects as control group. The results showed that there was a significant decrease in muscle reactance (X) and phase angle (θ) at selected frequencies (i.e., 50 and 100 kHz) in SCI compared to control. There was no significant difference in muscle resistance (R) between the two groups...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28673831/risk-factors-for-laryngeal-penetration-aspiration-in-patients-with-acute-traumatic-cervical-spinal-cord-injury
#17
Tiina Ihalainen, Irina Rinta-Kiikka, Teemu M Luoto, Tuomo Thesleff, Mika Helminen, Anna-Maija Korpijaakko-Huuhka, Antti Ronkainen
BACKGROUND CONTEXT: Laryngeal penetration-aspiration, entry of material into the airways, is considered the most severe subtype of dysphagia and common among patients with acute cervical spinal cord injury. PURPOSE: The aim of this study was to investigate risk factors for penetration-aspiration in patients with acute traumatic cervical spinal cord injury (TCSCI). STUDY DESIGN: A prospective cohort study. PATIENT SAMPLE: Thirty-seven patients with TCSCI...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28673827/the-impact-of-spine-stability-on-cervical-spinal-cord-injury-with-respect-to-demographics-management-and-outcome-a-prospective-cohort-from-a-national-sci-registry
#18
Jérôme Paquet, Carly S Rivers, Dilinuer Kuerban, Joel Finkelstein, Jin W Tee, Vanessa K Noonan, Brian K Kwon, R John Hurlbert, Sean Christie, Eve C Tsai, Henry Ahn, Brian Drew, Christopher S Bailey, Daryl R Fourney, Najmedden Attabib, Michael G Johnson, Michael G Fehlings, Stefan Parent, Marcel F Dvorak
BACKGROUND CONTEXT: Emergent surgery for patients with a traumatic spinal cord injury (SCI) is seen as the gold standard in acute management. However, optimal treatment for those with the clinical diagnosis of central cord syndrome (CCS) is less clear and classic definitions of CCS do not identify a unique population of patients. PURPOSE: To test the authors' hypothesis that spine stability can identify a unique group of patients with regards to demographics, management, and outcomes, which classic CCS definitions do not...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28673315/mortality-due-to-traumatic-spinal-cord-injuries-in-europe-a-cross-sectional-and-pooled-analysis-of-population-wide-data-from-22-countries
#19
Marek Majdan, Dominika Plancikova, Eva Nemcovska, Lenka Krajcovicova, Alexandra Brazinova, Martin Rusnak
BACKGROUND: Traumatic spinal cord injuries (TSCI) pose a significant burden globally, while existing epidemiological data-especially on population mortality-are limited. The aim of this study was to calculate the age-standardized population mortality rates attributable to TSCI in 22 European countries, along with the pooled age-standardized mortality rate attributable to TSCI in Europe. METHODS: A descriptive cross-sectional epidemiological study was conducted. Crude and age-standardized mortality rates attributable to TSCI for the year 2012 for 22 European countries were compared using data from death certificates provided by Eurostat...
July 3, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28669296/a-neurophysiological-approach-to-nerve-transfer-to-restore-upper-limb-function-in-cervical-spinal-cord-injury
#20
Ross M Mandeville, Justin M Brown, Geoffrey L Sheean
A successful nerve transfer surgery can provide a wealth of benefits to a patient with cervical spinal cord injury. The process of surgical decision making ideally uses all pertinent information to produce the best functional outcome. Reliance on clinical examination and imaging studies alone can miss valuable information on the state of spinal cord health. In this regard, neurophysiological evaluation has the potential to effectively gauge the neurological status of even select pools of anterior horn cells and their axons to small nerve branches in question to determine the potential efficacy of their use in a transfer...
July 2017: Neurosurgical Focus
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