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Splenic injury

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https://www.readbyqxmd.com/read/27901623/autotransplantation-of-spleen-mitigates-drug-induced-liver-damage-in-splenectomized-mice
#1
Sabrine Teixeira Ferraz Grunewald, Alice Belleigoli Rezende, Bárbara Bruna Muniz Figueiredo, Ana Carolina de Paula Mendonça, Caroline de Souza Almeida, Erick Esteves de Oliveira, Flávia de Paoli, Henrique Couto Teixeira
PURPOSE: The spleen presents numerous functions, including the production of immunoglobulins and blood filtration, removing microorganisms and cellular debris. The spleen also has anatomical and functional relationship with the liver, but there are few studies on this topic. The aim of this study was to assess the effect of splenectomy and autologous spleen transplantation on both filtering functions of spleen and acetaminophen-induced hepatotoxicity. MATERIALS AND METHODS: Fifty-two BALB/c mice were randomized into four groups: splenectomized; splenectomy and splenic autotransplantation in the greater omentum; sham operated control; and non-operated control...
November 30, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27878389/spleen-atrophy-related-immune-system-changes-attributed-to-infection-of-angiostrongylus-cantonensis-in-mouse-model
#2
Zhen Liu, Yu Wu, Ying Feng, Feng Wu, Rui-Feng Liu, Li-Fu Wang, Jin-Yi Liang, Jia-Hua Liu, Xi Sun, Zhong-Dao Wu
The spleen is one of the most important peripheral immune organs, which is frequently affected in infectious diseases. Infectious diseases can induce splenic alterations including splenic atrophy and functional alteration, while splenic atrophy may in turn interferes with recovery of infectious diseases. Angiostrongyliasis is an infectious disease by Angiostrongylus cantonensis (A. cantonensis), which invade non-permissive hosts, such as humans and mice, to cause severe damage to the central nervous system (CNS) and acute inflammatory response...
November 22, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27871094/biomechanical-responses-of-pmhs-subjected-to-abdominal-seatbelt-loading
#3
Rakshit Ramachandra, Yun-Seok Kang, John H Bolte, Alena Hagedorn, Rodney Herriott, Jason A Stammen, Kevin Moorhouse
Past studies have found that a pressure based injury risk function was the best predictor of liver injuries due to blunt impacts. In an effort to expand upon these findings, this study investigated the biomechanical responses of the abdomen of post mortem human surrogates (PMHS) to high-speed seatbelt loading and developed external response targets in conjunction with proposing an abdominal injury criterion. A total of seven unembalmed PMHS, with an average mass and stature of 71 kg and 174 cm respectively were subjected to belt loading using a seatbelt pull mechanism, with the PMHS seated upright in a freeback configuration...
November 2016: Stapp Car Crash Journal
https://www.readbyqxmd.com/read/27868093/conservative-management-of-combined-pleural-and-splenic-injury-during-percutaneous-nephrostolithotomy
#4
Geoffrey S Gaunay, Haris Ahmed, Arthur Smith, Zeph Okeke
Splenic injuries related to percutaneous nephrostolithotomy (PCNL) are infrequent. Herein, we report a combined splenic and pleural injury incurred during PCNL along with radiographic images documenting the complication. A review of management techniques for similar injuries is included.
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27866649/management-of-paediatric-splenic-injury-in-the-new-south-wales-trauma-system
#5
Susan E Adams, Andrew Holland, Julie Brown
: Since the 1980's, paediatric surgeons have increasingly managed blunt splenic injury (BSI) in children non-operatively. However, studies in North America have shown higher operation rates in non-paediatric centres and by adult surgeons. This association has not been examined elsewhere. OBJECTIVE: To investigate the management of BSI in New South Wales (NSW) children, to determine the patient and hospital factors related to the odds of operation. Secondarily, to investigate whether the likelihood of operation varied by year...
November 8, 2016: Injury
https://www.readbyqxmd.com/read/27849328/early-post-traumatic-splenic-arteriovenous-fistula-in-the-pancreatic-arcade-diagnosis-by-volume-rendered-3d-reconstruction-images
#6
Junya Tsurukiri, Hidefumi Sano, Hoshiai Akira, Naoyuki Kaneko
Arteriovenous fistula (AVF) of splenic vessels is rare. It is most commonly caused by spontaneous rupture of an extant splenic artery aneurysm into an adjacent vein, or by traumatic or iatrogenic pseudoaneurysm. Blunt abdominal trauma can sometimes lead to vascular damage to spleen, resulting in AVF formation. Presently described is case of an elderly patient with high-grade splenic injury. Early post-traumatic AVF was detected by volume-rendered 3D reconstruction using fused arterial and venous phase computed tomography (CT) images...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27849061/mitigation-of-radiation-induced-hematopoietic-injury-by-the-polyphenolic-acetate-7-8-diacetoxy-4-methylthiocoumarin-in-mice
#7
Kavya Venkateswaran, Anju Shrivastava, Paban K Agrawala, Ashok Prasad, Namita Kalra, Parvat R Pandey, Kailash Manda, Hanumantharao G Raj, Virinder S Parmar, Bilikere S Dwarakanath
Protection of the hematopoietic system from radiation damage, and/or mitigation of hematopoietic injury are the two major strategies for developing medical countermeasure agents (MCM) to combat radiation-induced lethality. In the present study, we investigated the potential of 7, 8-diacetoxy-4-methylthiocoumarin (DAMTC) to ameliorate radiation-induced hematopoietic damage and the associated mortality following total body irradiation (TBI) in C57BL/6 mice. Administration of DAMTC 24 hours post TBI alleviated TBI-induced myelo-suppression and pancytopenia, by augmenting lymphocytes and WBCs in the peripheral blood of mice, while bone marrow (BM) cellularity was restored through enhanced proliferation of the stem cells...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818226/-primary-care-of-the-blunt-splenic-injured-adult
#8
REVIEW
Brian Yorkgitis
The spleen is the most commonly injured abdominal organ in blunt trauma. Immediate treatment is aimed at assessing for bleeding and abating it when it is severe. Methods for the management of blunt splenic injury associated bleeding include observation, splenectomy and splenic salvage procedures through splenorrhaphy or embolization. After blunt splenic injury, complications commonly occur, including bleeding, infection, thrombosis and pneumonia. If a patient undergoes splenectomy, infections can be severe...
November 3, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27817834/a-comparison-study-of-pelvic-fractures-and-associated-abdominal-injuries-between-pediatric-and-adult-blunt-trauma-patients
#9
Forat Swaid, Kobi Peleg, Ricardo Alfici, Oded Olsha, Adi Givon, Boris Kessel
PURPOSE: Pelvic fractures are a marker of severe injury, mandating a thorough investigation for the presence of associated injuries. Anatomical and physiological differences between adults and children may lead to a different impact of pelvic fractures on these populations. The purpose of this study is to compare pelvic fractures between pediatric and adult blunt trauma victims, mainly regarding their severity and associated intraabdominal injuries. METHODS: A retrospective study involving blunt trauma patients suffering pelvic fractures, according to the records of the Israeli National Trauma Registry...
September 23, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27810135/time-is-now-venous-thromboembolism-prophylaxis-in-blunt-splenic-injury
#10
Amy M Kwok, James W Davis, Rachel C Dirks, Mary M Wolfe, Krista L Kaups
BACKGROUND: The safety and timing of venous thromboembolism (VTE) prophylaxis in patients with blunt splenic injuries is not well known. We hypothesized that early initiation of VTE prophylaxis does not increase failure of nonoperative management or transfusion requirements in these patients. METHODS: A retrospective review of trauma patients with blunt splenic injury was performed. Patients were compared based on initiation and timing of VTE prophylaxis (<24 hours, 24 to 48 hours, 48 to 72 hours, and >72 hours)...
September 30, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27799486/sphingosine-kinase-2-deficiency-attenuates-kidney-fibrosis-via-ifn-%C3%AE
#11
Amandeep Bajwa, Liping Huang, Elvira Kurmaeva, Hong Ye, Krishna R Dondeti, Piotr Chroscicki, Leah S Foley, Z Ayoade Balogun, Kyle J Alexander, Hojung Park, Kevin R Lynch, Diane L Rosin, Mark D Okusa
Maladaptive repair after AKI may lead to progressive fibrosis and decline in kidney function. Sphingosine 1-phosphate has an important role in kidney injury and pleiotropic effects in fibrosis. We investigated the involvement of sphingosine kinase 1 and 2 (SphK1 and SphK2), which phosphorylate sphingosine to produce sphingosine 1-phosphate, in kidney fibrosis induced by folic acid (FA) or unilateral ischemia-reperfusion injury. Analysis of Masson trichrome staining and fibrotic marker protein and mRNA expression 14 days after AKI revealed that wild-type (WT) and Sphk1(-/-) mice exhibited more kidney fibrosis than Sphk2(-/-) mice...
October 31, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27798008/does-angiography-increase-the-risk-of-impairment-in-renal-function-during-non-operative-management-of-patients-with-blunt-splenic-injuries-a-cross-sectional-study-in-southern-taiwan
#12
Ting-Min Hsieh, Tzu-Hsien Tsai, Chih-Che Lin, Ching-Hua Hsieh
OBJECTIVES: The aim of the present study was to assess whether angiography after contrast-enhanced CT (CECT) as per the policy of non-operative management would add to the risk of acute kidney injury in patients with blunt splenic injuries (BSIs). DESIGN: Cross-sectional study. SETTING: Taiwan. PARTICIPANTS: Patients with BSI aged >16 years, admitted to a level I trauma centre during the period of January 2004 to December 2014, were retrospectively reviewed...
October 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27791418/a-review-of-the-management-of-blunt-splenic-trauma-in-england-and-wales-have-regional-trauma-networks-influenced-management-strategies-and-outcomes
#13
P Yiannoullou, C Hall, K Newton, B Pearce, O Bouamra, T Jenks, A B Scrimshire, G Hughes, F Lecky, Adh Macdonald
INTRODUCTION The spleen remains one of the most frequently injured organs following blunt abdominal trauma. In 2012, regional trauma networks were launched across England and Wales with the aim of improving outcomes following trauma. This retrospective cohort study investigated the management and outcomes of blunt splenic injuries before and after the establishment of regional trauma networks. METHODS A dataset was drawn from the Trauma Audit Research Network database of all splenic injuries admitted to English and Welsh hospitals from 1 April 2010 to 31 March 2014...
October 28, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27779977/anticipated-transfusion-requirements-and-mortality-in-patients-with-orthopedic-and-solid-organ-injuries
#14
Devon S Callahan, Zane Ashman, Dennis Y Kim, David S Plurad
Long bone fractures are cited as an etiology for significant blood loss; however, there is scant supporting literature. We examined the relationship between long bone fractures, blood transfusions, and solid organ injuries. We hypothesize that transfusions are rare with long bone fractures in the absence of a liver or splenic injury. We performed a retrospective analysis of patients admitted with femur, tibia, and humerus fractures. Outcomes included transfusion requirements and mortality. A total of 1837 patients were included...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27779578/does-small-volume-resuscitation-with-crystalloids-or-colloids-influence-hemostasis-and-survival-of-rabbits-subjected-to-lethal-uncontrolled-hemorrhage
#15
Bijan S Kheirabadi, Nahir Miranda, Irasema B Terrazas, Mary D Gonzales, Rose C Grimm, Michael A Dubick
INTRODUCTION: Prehospital, small-volume resuscitation of combat casualties with a synthetic colloid [6% hydroxyethyl starch (HES) 670/0.75] has been recommended when blood or blood components are unavailable. We studied hemostatic effects of a newer synthetic colloid (6% HES 130/0.4,) compared to either a natural colloid (albumin) or to crystalloids in an uncontrolled hemorrhage model. METHODS: Spontaneously breathing NZW rabbits (3.4±0.1 kg) were anesthetized, instrumented and subjected to a splenic injury with uncontrolled bleeding...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27777380/aging-dysregulates-d-and-e-series-resolvins-to-modulate-cardiosplenic-and-cardiorenal-network-following-myocardial-infarction
#16
Ganesh V Halade, Vasundhara Kain, Laurence M Black, Sumanth D Prabhu, Kevin A Ingle
Post-myocardial infarction (MI), overactive inflammation is the hallmark of aging, however, the mechanism is unclear. We hypothesized that excess influx of omega 6 fatty acids may impair resolution, thus impacting the cardiosplenic and cardiorenal network post-MI. Young and aging mice were fed on standard lab chow (LC) and excess fatty acid (safflower oil; SO)-enriched diet for 2 months and were then subjected to MI surgery. Despite similar infarct areas and left ventricle (LV) dysfunction post-MI, splenic mass spectrometry data revealed higher levels of arachidonic acid (AA) derived pro-inflammatory metabolites in young-SO, but minimal formation of docosanoids, D- and E- series resolvins in SO-fed aged mice...
October 18, 2016: Aging
https://www.readbyqxmd.com/read/27772587/splenic-artery-ligation-for-iatrogenic-injury-in-esophagectomy-operations
#17
Zuodong Song, Ting Ye, Longfei Ma, Longlong Shao, Dong Lin, Shujun Jiang, Jiaqing Xiang
Studies have shown that splenic artery ligation without splenectomy can successfully control hemorrhage and preserve the spleen in splenic trauma. The short gastric arteries and left gastroepiploic arteries may be the most important part of the collateral blood supply to the spleen. Moreover, that the human spleen can also survive even if most of the short gastric arteries have been ligated along with the splenic artery has also been proven. Revascularization of the spleen by collateral vessels from the superior mesenteric, pancreatic, and left inferior phrenic arteries has been demonstrated by celiac angiography...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27770815/human-endometrial-regenerative-cells-alleviate-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#18
Shanzheng Lu, Ganggang Shi, Xiaoxi Xu, Grace Wang, Xu Lan, Peng Sun, Xiang Li, Baoren Zhang, Xiangying Gu, Thomas E Ichim, Hao Wang
BACKGROUND: The endometrial regenerative cell (ERC) is a novel type of adult mesenchymal stem cell isolated from menstrual blood. Previous studies demonstrated that ERCs possess unique immunoregulatory properties in vitro and in vivo, as well as the ability to differentiate into functional hepatocyte-like cells. For these reasons, the present study was undertaken to explore the effects of ERCs on carbon tetrachloride (CCl4)-induced acute liver injury (ALI). METHODS: An ALI model in C57BL/6 mice was induced by administration of intraperitoneal injection of CCl4...
October 22, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27741526/extraluminal-migration-of-an-esophageal-metal-stent-causing-splenic-injury
#19
Saad Khan, Nayana George, Benjamin Tharian
No abstract text is available yet for this article.
January 2016: Endoscopy
https://www.readbyqxmd.com/read/27733201/activation-of-the-hypothalamic-pituitary-adrenal-hpa-axis-contributes-to-the-immunosuppression-of-mice-infected-with-angiostrongylus-cantonensis
#20
Ai-Ling Chen, Xi Sun, Wei Wang, Jin-Feng Liu, Xin Zeng, Jing-Fan Qiu, Xin-Jian Liu, Yong Wang
BACKGROUND: Immunosuppression has been described as a consequence of brain injury and infection by different mechanisms. Angiostrongylus cantonensis can cause injury to the central nervous system and eosinophilic meningitis to human. Both T cell and B cell immunity play an essential role in the resistance of the infection. However, whether brain injury caused by A. cantonensis infection can lead to immunosuppression is not clear. Therefore, the present study sought to observe the alteration of immune responses in mice infected with A...
October 12, 2016: Journal of Neuroinflammation
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