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Hypertension in CKD

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https://www.readbyqxmd.com/read/29655688/novel-ras-inhibitor-25-o-methylalisol-f-attenuates-epithelial-to-mesenchymal-transition-and-tubulo-interstitial-fibrosis-by-selectively-inhibiting-tgf-%C3%AE-mediated-smad3-phosphorylation
#1
Hua Chen, Tian Yang, Min-Chang Wang, Dan-Qian Chen, Yang Yang, Ying-Yong Zhao
BACKGROUND: Tubulo-interstitial fibrosis (TIF) is the common pathway in the chronic kidney disease (CKD). Epithelial-to-mesenchymal transition (EMT) is a major contributor to the TIF by the increased myofibroblasts. Renin-angiotensin system (RAS) is critical mediator on EMT in progressive CKD. Angiotensin II (ANG) mediates EMT and causes TIF by stimulating transforming growth factor-β1 (TGF-β1). RAS activation could further activate TGF-β1. Inhibition of the RAS is one of the most powerful therapies for progressive CKD...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29650676/sodium-bicarbonate-loading-limits-tubular-cast-formation-independent-of-glomerular-injury-and-proteinuria-in-dahl-salt-sensitive-rats
#2
S C Ray, B Patel, D L Irsik, J Sun, H Ocasio, G R Crislip, C H Jin, J K Chen, B Baban, A J Polichnowski, P M O'Connor
Sodium bicarbonate (NaHCO3 ) slows the decline in kidney function in patients with chronic kidney disease (CKD), yet the mechanisms mediating this effect remain unclear. The Dahl salt-sensitive (SS) rat develops hypertension and progressive renal injury when fed a high salt diet; however, the effect of alkali loading on kidney injury has never been investigated in this model. We hypothesized that 'NaHCO3 protects from the development of renal injury in Dahl salt-sensitive rats via luminal alkalization which limits the formation of tubular casts, which are a prominent pathological feature in this model...
April 12, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29629277/weight-loss-has-an-additive-effect-on-the-proteinuria-reduction-of-angiotensin-ii-receptor-blockers-in-hypertensive-patients-with-chronic-kidney-disease
#3
Shin Young Ahn, Dong Ki Kim, Seung Seok Han, Jung Hwan Park, Sung Joon Shin, Sang Ho Lee, Bum Soon Choi, Chun Soo Lim, Suhnggwon Kim, Ho Jun Chin
Background: Weight reduction is a lifestyle intervention that has been introduced for prevention and management of chronic kidney disease (CKD). We investigate the additive anti-proteinuric effect of weight reduction on the usage of angiotensin II receptor blockers (ARBs) and its potential mechanisms in hypertensive CKD patients. Methods: This study is a subanalysis of data from an open-label, randomized, controlled clinical trial. Among the 235 participants, 227 were assigned to subgroups according to changes in body weight...
March 2018: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/29628278/left-atrial-dilatation-a-target-organ-damage-in-young-to-middle-age-hypertensive-patients-the-campania-salute-network
#4
Costantino Mancusi, Grazia Canciello, Raffaele Izzo, Silvia Damiano, Maria Gabriella Grimaldi, Nicola de Luca, Giovanni de Simone, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Left atrial (LA) volume is a predictor of outcome in hypertension. It is unclear whether or not this effect depends on coexisting target organ damage (TOD). PURPOSE: To investigate whether LA volume predicts outcome independently of TOD [left ventricular (LV) hypertrophy (LVH) and/or carotid plaque] in a registry of hypertensive treated patients. METHODS: From the Campania Salute Network registry, we selected 5844 young adult hypertensive patients <65 years old (mean age 50 ± 9 years, 41% women, 8% diabetic) without prevalent CV or valvular heart disease more than mild, with normal LV ejection fraction, stage III or less CKD and available follow-up...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29619487/etiology-ethics-and-outcomes-of-chronic-kidney-disease-in-neonates
#5
Jameela A Kari, Sara N Sharief, Sherif M El Desoky, Khalid A Alhasan, Amr S Albanna
OBJECTIVES: To report the epidemiology of chronic kidney disease (CKD)  in neonates at a single tertiary center and the outcomes of renal replacement therapy (RRT) in these patients and discuss ethical considerations regarding RRT in this population. METHODS: In this retrospective study, we reviewed clinical data from all neonates with evidence of CKD who were followed up at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia between 2005 and 2015. Follow-up serum creatinine levels were recorded every 6 months...
April 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29616601/does-neutrophil-to-lymphocyte-ratio-demonstrate-deterioration-in-renal-function
#6
Senol Tonyali, Cavit Ceylan, Sedat Yahsi, Mine Sebnem Karakan
INTRODUCTION: Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy. METHODS: We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient...
November 2018: Renal Failure
https://www.readbyqxmd.com/read/29615792/exercise-in-patients-with-hypertension-and-chronic-kidney-disease-a-randomized-controlled-trial
#7
Franklin C Barcellos, Fabricio Boscolo Del Vecchio, Annelise Reges, Gregore Mielke, Iná S Santos, Daniel Umpierre, Maristela Bohlke, Pedro C Hallal
Hypertension and chronic kidney disease (CKD) are global public health problems, both associated with higher risk of cardiovascular (CV) and renal events. This trial randomized non-diabetic adult patients with hypertension and CKD stages 2-4 to 16 weeks of aerobic and resistance training or usual care. The primary outcome was the change in estimated glomerular filtration rate (eGFR). Secondary outcomes included changes in systolic and diastolic blood pressure (BP), body weight, fasting blood glucose, lipid profile, high-sensitivity C-reactive protein (hs-CRP), and functional capacity...
April 4, 2018: Journal of Human Hypertension
https://www.readbyqxmd.com/read/29615173/outcome-of-chronic-kidney-disease-patients-on-the-basis-of-referral-to-nephrologist-a-one-year-follow-up-study
#8
Muhammad Anees, Yasir Hussain, Muhammad Ibrahim, Irfan Ilahi, Sajjad Ahmad, Khushbakht Isma Asif, Amina Jameel
OBJECTIVE: To determine the outcome of chronic kidney disease (CKD) patients presenting for dialysis on the basis of referral to nephrologist. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Nephrology Department of King Edward Medical University/Mayo Hospital, Lahore, from January 2014 to January 2016. METHODOLOGY: All patients who were presented in nephrology outpatients department and with the indication of dialysis were included in study...
April 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29602711/tenofovir-disoproxil-fumarate-co-administered-with-lopinavir-ritonavir-is-strongly-associated-with-tubular-damage-and-chronic-kidney-disease
#9
Daisuke Mizushima, Dung Thi Hoai Nguyen, Dung Thi Nguyen, Shoko Matsumoto, Junko Tanuma, Hiroyuki Gatanaga, Nguyen Vu Trung, Nguyen van Kinh, Shinichi Oka
BACKGROUD: With expanding antiretroviral therapy (ART) in a resource-limited setting, the use of second line ART with ritonavir boosted lopinavir (LPV/r) is increasing. However, little is known regarding the renal safety of tenofovir (TDF) co-administered with LPV/r. METHODS: In total 1382 HIV-infected patients were enrolled and data were recorded twice (October 2014 and 2015) in Vietnam. Tubular dysfunction (TD) was defined as urinary beta 2 microglobulin (β2MG) > 1000 μg/L at both timepoints or increase in β2MG by > 2000 μg/L...
March 27, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29601413/masked-hypertension-and-kidney-function-decline-the-jackson-heart-study
#10
Stanford Mwasongwe, Yuan-I Min, John N Booth, Ronit Katz, Mario Sims, Adolfo Correa, Bessie Young, Paul Muntner
BACKGROUND: Hypertension diagnosed by blood pressure (BP) measured in the clinic is associated with rapid kidney function decline (RKFD) and incident chronic kidney disease (CKD). The extent to which hypertension defined using out-of-clinic BP measurements is associated with these outcomes is unclear. METHODS: We evaluated the association of any masked hypertension (daytime SBP/DBP ≥ 135/85 mmHg, night-time SBP/DBP ≥ 120/70 mmHg or 24-h SBP/DBP ≥ 130/80 mmHg) with RKFD and incident CKD among 676 African-Americans in the Jackson Heart Study with clinic-measured SBP/DBP less than 140/90 mmHg who completed ambulatory BP monitoring in 2000-2004...
March 29, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29593020/ethnic-differences-in-the-progression-of-chronic-kidney-disease-and-risk-of-death-in-a-uk-diabetic-population-an-observational-cohort-study
#11
Rohini Mathur, Gavin Dreyer, Magdi M Yaqoob, Sally A Hull
OBJECTIVE: To determine ethnic differences in the progression of chronic kidney disease (CKD) and risk of end-stage renal failure (ESRF) and death in adults with type 2 diabetes mellitus (T2DM), and to identify predictors of rapid renal decline. DESIGN: Observational community-based cohort study undertaken from 2006 to 2016 with nested case-control study. SETTING: 135 inner London primary care practices contributing to the east London Database...
March 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29589837/blood-pressure-management-and-progression-of-chronic-kidney-disease-in-a-canine-remnant-kidney-model
#12
Jun G Kang, Mi-Yeon Yu, Hajeong Lee, Dong K Kim, Kwon W Joo, Yon S Kim, Seung H Yang
The canine remnant kidney model is fundamental to understanding the relationship between hypertension and chronic kidney disease (CKD). This study aimed to create a 1/16 remnant kidney model and to determine whether blood pressure (BP) control affects the progression of CKD. A group of dogs received BP treatment (group A) and another received BP treatment except for the first 2 weeks (group B). The remnant kidney model was induced using a two-step subtotal nephrectomy method; dogs received antihypertensive therapy...
March 28, 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29589268/changes-in-trace-elements-during-early-stages-of-chronic-kidney-disease-in-type-2-diabetic-patients
#13
Ching-Chiang Lin, Ching-Tang Shih, Chien-Hung Lee, Yeou-Lih Huang
Trace elements can influence glucose metabolism and be related to oxidative stress in type 2 diabetes mellitus. Moreover, trace elements play important roles in the nephrotic complications of these patients. Nevertheless, few investigations have been made into the changes in the levels of trace elements in diabetic patients at various stages of chronic kidney disease (CKD). The aims of this present study were to determine the levels of some important trace elements in diabetic patients during the early stages of CKD and to identify the relationship between these elements and CKD progression in type 2 diabetic patients...
March 28, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29582339/prevalence-of-pulmonary-hypertension-in-patients-with-chronic-kidney-disease-without-dialysis-a-meta-analysis
#14
Weifeng Shang, Yuanyuan Li, Yali Ren, Wei Li, HongLan Wei, Junwu Dong
PURPOSE: Recent epidemiological evidence attempts to demonstrate the risk of pulmonary hypertension (PH) among patients with chronic kidney disease (CKD) without dialysis, but prevalence estimates of PH in CKD without dialysis vary widely in the existing studies. This meta-analysis was to summarize the point prevalence of PH in adults with CKD without dialysis. METHODS: PubMed, EMBASE, the Cochrane Collaboration, and the reference lists of relevant articles were searched to identify eligible studies...
March 26, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29581235/myeloperoxidase-derived-oxidants-damage-artery-wall-proteins-in-an-animal-model-of-chronic-kidney-disease-accelerated-atherosclerosis
#15
Lixia Zeng, Anna V Mathew, Jaeman Byun, Kevin B Atkins, Frank C Brosius, Subramaniam Pennathur
Increased myeloperoxidase (MPO) levels and activity are associated with increased cardiovascular risk among individuals with chronic kidney disease (CKD). However, a lack of good animal models for examining the presence and catalytic activity of MPO in vascular lesions has impeded mechanistic studies into CKD-associated cardiovascular diseases. Here, we show for the first time that exaggerated atherosclerosis in a pathophysiologically relevant CKD mouse model is associated with increased macrophage-derived MPO activity...
March 26, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29580865/bone-marrow-mesenchymal-stromal-cell-infusion-in-patients-with-chronic-kidney-disease-a-safety-study-with-18-months-of-follow-up
#16
Atieh Makhlough, Soroosh Shekarchian, Reza Moghadasali, Behzad Einollahi, Mona Dastgheib, Ghasem Janbabaee, Seyedeh Esmat Hosseini, Nasrin Falah, Fateme Abbasi, Hossein Baharvand, Nasser Aghdami
BACKGROUND: Chronic kidney disease (CKD) is a progressive loss of kidney function and structure that affects approximately 13% of the population worldwide. A recent meta-analysis revealed that cell-based therapies improve impaired renal function and structure in preclinical models of CKD. We assessed the safety and tolerability of bone marrow-mesenchymal stromal cell (MSC) infusion in patients with CKD. METHODS: A single-arm study was carried out at one center with 18-month follow-up in seven eligible patients with CKD due to different etiologies such as hypertension, nephrotic syndrome (NS) and unknown etiology...
March 23, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29580580/treatment-of-diabetic-kidney-disease-with-hypertension-control-and-renin-angiotensin-system-inhibition
#17
REVIEW
Vikram Patney, Kunal Chaudhary, Adam Whaley-Connell
The global incidence and prevalence of diabetes continues to expand due primarily to the influences of obesity and the contribution of obesity to the progression of type 2 diabetes mellitus. The rising prevalence of type 2 diabetes has driven an increase in rates of CKD in the past 3 decades in the United States. In turn, so have the rates for complications related to type 2 diabetes including CKD, eg, diabetic kidney disease (DKD). Although incident rates for DKD have stabilized in the recent years, diabetes continues to be the leading cause of ESRD in the United States...
March 2018: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29578207/use-of-oral-anticoagulants-in-patients-with-atrial-fibrillation-and-renal-dysfunction
#18
REVIEW
Tatjana S Potpara, Charles J Ferro, Gregory Y H Lip
Atrial fibrillation (AF) and chronic kidney disease (CKD) are increasingly prevalent in the general population and share common risk factors such as older age, hypertension and diabetes mellitus. The presence of CKD increases the risk of incident AF, and, likewise, AF increases the risk of CKD development and/or progression. Both conditions are associated with substantial thromboembolic risk, but patients with advanced CKD also exhibit a paradoxical increase in bleeding risk. In the landmark randomized clinical trials that compared non-vitamin K antagonist oral anticoagulants (NOACs) with warfarin for thromboprophylaxis in patients with AF, the efficacy and safety of NOACs in patients with mild-to-moderate CKD were similar to those in patients without CKD...
March 26, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29578191/unenhanced-renal-magnetic-resonance-angiography-in-patients-with-chronic-kidney-disease-suspected-renovascular-hypertension-can-it-affect-patient-management
#19
J Yamuna, Anupama Chandrasekharan, Rajeswaran Rangasami, S Ramalakshmi, Santhosh Joseph
Background & objectives: Renal artery stenosis (RAS) is an important cause of severe hypertension in patients with chronic kidney disease (CKD). It is important to detect RAS early as it can reverse hypertension and stop rapid deterioration of renal function. The potential drawbacks of various imaging modalities used to detect RAS including contrast-related adverse effects associated with diagnostic angiography have led to increasing interest in unenhanced magnetic resonance (MR) renal angiography...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29577540/burden-of-cardio-renal-metabolic-conditions-in-adults-with-type-2-diabetes-within-the-diabetes-collaborative-registry
#20
Suzanne V Arnold, Mikhail Kosiborod, Jingyan Wang, Peter Fenici, Goran Gannedahl, Robert J LoCasale
We examined the prevalence of cardio-renal-metabolic (CaReMe) conditions and their combinations among 530,747 adults with type 2 diabetes in a US-based outpatient registry of 271 primary care, cardiology, and endocrinology offices. We evaluated the following CaReMe conditions: hypertension, hyperlipidemia, coronary artery disease (CAD), chronic kidney disease (CKD), cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and gout or hyperuricemia; prevalence estimates were adjusted based on the distribution of diabetes by age in the 2015 US population...
March 25, 2018: Diabetes, Obesity & Metabolism
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