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https://www.readbyqxmd.com/read/29227894/substance-induced-psychotic-symptoms-in-borderline-personality-disorder-among-substance-use-disorder-samples-in-spain
#1
Carmen Barral, Laia Rodríguez-Cintas, Lara Grau-López, Constanza Daigre, Elena Ros-Cucurull, Natalia Calvo, Marc Ferrer, Carlos Roncero
Substance-induced psychosis (SIP) is frequent in substance use disorder patients. However, little is known about the presence of SIP in Borderline Personality Disorder (BPD) and what the risk factors for the development of SIP in this population would be. A sample of 91 BPD drug-dependent patients attending an outpatient substance use disorder unit was evaluated. Comorbidity with Axis I and II was assessed using SCID-I and SCID-II. Psychoactive drug related variables were registered as well as the presence of the ninth criterion of DSM-IV-TR as a code of psychotic symptoms...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29227814/synthesis-and-evaluation-of-99mtc-re-tricarbonyl-complexes-of-the-triphenylphosphonium-cation-for-mitochondrial-targeting
#2
Georgios Paparidis, Melpomeni Akrivou, Vicky Tsachouridou, Antonio Shegani, Ioannis S Vizirianakis, Ioannis Pirmettis, Minas S Papadopoulos, Dionysia Papagiannopoulou
INTRODUCTION: Lipophilic delocalized cations accumulate in tumor cell mitochondria due to their higher transmembrane potential. In this work, this strategy was adopted for the development of 99mTc tumor-targeted imaging agents. METHODS: Two tridentate ligands containing the triphenylphosphonium cation, L1 (S-cysteinyl) and L2 (N-iminodiacetate) as well as the respective 99mTc/ReL1 and 99mTc/ReL2 tricarbonyl complexes were synthesized. The effect of the ligands and the Re complexes on cell growth in U-87 MG glioblastoma cells was assessed...
November 13, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29222435/long-term-maintenance-of-peripheral-blood-derived-human-nk-cells-in-a-novel-human-il-15-transgenic-nog-mouse
#3
Ikumi Katano, Chiyoko Nishime, Ryoji Ito, Tsutomu Kamisako, Takuma Mizusawa, Yuyo Ka, Tomoyuki Ogura, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ null (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months without signs of xenogeneic graft versus host diseases (xGVHD). These in vivo-expanded hu-PB-NK cells maintained the original expression patterns of various surface antigens, including NK receptors and killer cell immunoglobulin-like receptor (KIR) molecules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221170/proteoglycan-targeting-applied-to-hypoxia-activated-prodrug-therapy-in-chondrosarcoma-first-proof-of-concept
#4
Aurélien Voissiere, Valérie Weber, Yvain Gerard, Françoise Rédini, Florian Raes, Jean-Michel Chezal, Françoise Degoul, Caroline Peyrode, Elisabeth Miot-Noirault
Due to its abundant chondrogenic matrix and hypoxic tissue, chondrosarcoma is chemo- and radio-resistant. Our group has developed a proteoglycan targeting strategy by using a quaternary ammonium (QA) function as a carrier of DNA alkylating agents to chondrosarcoma environment. Here, we assessed the relevance of this strategy applied to hypoxia-activated prodrugs, by conjugating a QA to 2-nitroimidazole phosphoramidate. This derivative, named as 8-QA, was evaluated respectively to its non-QA equivalent and to a QA-conjugated but non-hypoxia activated...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221156/the-protective-role-of-sphingosine-1-phosphate-against-the-action-of-the-vascular-disrupting-agent-combretastatin-a-4-3-o-phosphate
#5
Joanna Shepherd, Matthew Fisher, Abigail Welford, Donald M McDonald, Chryso Kanthou, Gillian M Tozer
Solid tumours vary in sensitivity to the vascular disrupting agent combretastatin A-4 3-O-phosphate (CA4P), but underlying factors are poorly understood. The signaling sphingolipid, sphingosine-1-phosphate (S1P), promotes vascular barrier integrity by promoting assembly of VE-cadherin/β-catenin complexes. We tested the hypothesis that tumour pre-treatment with S1P would render tumours less susceptible to CA4P. S1P (1μM) pretreatment attenuated an increase in endothelial cell (HUVEC) monolayer permeability induced by 10μM CA4P...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29215317/novel-application-and-serial-evaluation-of-tissue-engineered-portal-vein-grafts-in-a-murine-model
#6
Mark W Maxfield, Mitchel R Stacy, Hirotsugu Kurobe, Shuhei Tara, Tai Yi, Muriel A Cleary, Zhen W Zhuang, Manuel I Rodriguez-Davalos, Sukru H Emre, Yasuko Iwakiri, Toshiharu Shinoka, Christopher K Breuer
AIM: Surgical management of pediatric extrahepatic portal vein obstruction requires meso-Rex bypass using autologous or synthetic grafts. Tissue-engineered vascular grafts (TEVGs) provide an alternative, but no validated animal models using portal TEVGs exist. Herein, we preclinically assess TEVGs as portal vein bypass grafts. MATERIALS & METHODS: TEVGs were implanted as portal vein interposition conduits in SCID-beige mice, monitored by ultrasound and micro-computed tomography, and histologically assessed postmortem at 12 months...
December 7, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/29212135/what-is-the-effect-on-comorbid-personality-disorder-of-brief-panic-focused-psychotherapy-in-patients-with-panic-disorder
#7
John R Keefe, Barbara L Milrod, Robert Gallop, Jacques P Barber, Dianne L Chambless
BACKGROUND: No studies of psychotherapies for panic disorder (PD) have examined effects on comorbid personality disorders (PersD), yet half such patients have a PersD. METHODS: In a randomized trial for PD with and without agoraphobia comparing Cognitive-Behavioral Therapy (CBT) and Panic-Focused Psychodynamic Psychotherapy (PFPP), PersD was assessed pre-to-post treatment with the Structured Clinical Interview for the Diagnosis of Axis-II Disorders (SCID-II). For patients completing therapy (n = 118, 54 with PersD), covariance between panic and SCID-II criteria improvements was analyzed...
December 6, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/29211557/acoustophoretic-purification-of-platelets-feasibility-and-impact-on-platelet-activation-and-function
#8
Pierre Bohec, Jérémie Gachelin, Véronique Ollivier, Thibaut Mutin, Xavier Télot, Benoît Ho-Tin-Noé, Sandra Sanfilippo
Purity, limited platelet activation, and preservation of platelet function are important stakes of preparation of platelet concentrates (PC) for clinical use. In fact, contaminating red blood cells and leukocytes, as well as activated and/or poorly functional platelets in PC, represents a risk of poor efficiency and adverse side effects during platelet transfusion. Therefore, optimization of preparation and storage of PC is still an active field of research. Shear-induced platelet activation is an unwanted side effect of the hard-spin (up to 5000g) step of centrifugation-based methods currently used in blood banks to prepare PC from whole blood samples...
December 6, 2017: Platelets
https://www.readbyqxmd.com/read/29208932/mouse-papillomavirus-infection-persists-in-mucosal-tissues-of-an-immunocompetent-mouse-strain-and-progresses-to-cancer
#9
Nancy M Cladel, Lynn R Budgeon, Karla K Balogh, Timothy K Cooper, Sarah A Brendle, Neil D Christensen, Todd D Schell, Jiafen Hu
Mouse papillomavirus has shown broad tissue tropism in nude mice. Previous studies have tested cutaneous infections in different immunocompromised and immunocompetent mouse strains. In the current study, we examined mucosal infection in several immunocompetent and immunocompromised mouse strains. Viral DNA was monitored periodically by Q-PCR of lavage samples. Immunohistochemistry and in situ hybridization were used to determine viral capsid protein and viral DNA respectively. All athymic nude mouse strains showed active infections at both cutaneous and mucosal sites...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207978/potential-therapeutic-effects-of-n-butylidenephthalide-from-radix-angelica-sinensis-danggui-in-human-bladder-cancer-cells
#10
Sheng-Chun Chiu, Tsung-Lang Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Cheng-Yoong Pang, Teng-Fu Hsieh
BACKGROUND: N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still unclear and worth for further investigate. METHODS: Changes of patients with bladder cancer after Angelica Sinensis exposure were evaluated by analysis of Taiwan's National Health Insurance Research Database (NHIRD) database. The anti-proliferative effect of BP on human bladder cancer cells was investigated and their cell cycle profiles after BP treatment were determined by flow cytometry...
December 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29207662/tumor-associated-macrophages-promote-neuroblastoma-via-stat3-phosphorylation-and-up-regulation-of-c-myc
#11
Michael D Hadjidaniel, Sakunthala Muthugounder, Long T Hung, Michael A Sheard, Soheila Shirinbak, Randall Y Chan, Rie Nakata, Lucia Borriello, Jemily Malvar, Rebekah J Kennedy, Hiroshi Iwakura, Takashi Akamizu, Richard Sposto, Hiroyuki Shimada, Yves A DeClerck, Shahab Asgharzadeh
Tumor-associated macrophages (TAMs) are strongly associated with poor survival in neuroblastomas that lack MYCN amplification. To study TAM action in neuroblastomas, we used a novel murine model of spontaneous neuroblastoma lacking MYCN amplification, and observed recruitment and polarization of TAMs, which in turn enhanced neuroblastoma proliferation and growth. In both murine and human neuroblastoma cells, we found that TAMs increased STAT3 activation in neuroblastoma cells and transcriptionally up-regulated the MYC oncogene...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205675/exploring-associations-between-psychiatric-disorder-psychological-distress-and-healthcare-utilization-in-cancer-patients
#12
F R Compen, E M M Adang, E M Bisseling, M L Van der Lee, A E M Speckens
OBJECTIVE: The mental burden of cancer might elicit additional healthcare utilization. However, it is unclear how psychiatric disorder and psychological distress relate to healthcare utilization. Therefore, this study explores associations between psychiatric disorder, psychological distress and healthcare utilization. It was hypothesized that presence of psychiatric disorder and psychological distress were associated with increased healthcare utilization and costs. METHODS: The current study consisted of secondary analyses of baseline data of a larger randomized controlled trial...
December 4, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29197208/occurrence-of-post-injection-delirium-sedation-syndrome-after-application-of-olanzapine-long-acting-injection-during-one-year-period
#13
Suzana Uzun, Oliver Kozumplik, Ivan Ćelić, Nela Pivac, Ninoslav Mimica
INTRODUCTION: The aim was to report the occurrence of after application of olanzapine long-acting injection (OLAI) in patients with schizophrenia during one year period. SUBJECTS AND METHODS: During one year period, OLAI was applied to 30 patients with schizophrenia (18 men, 12 women) who were non-adherent to previous treatment with oral olanzapine. Patients were 20-58 years of age (39 years old on average), diagnosed with SCID based on DSM-IV-TR criteria. Patients received OLAI in dosage between 210-405 mg (287±62 (mean ± SD)) every 2-4 weeks...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29189086/case-series-of-diagnostic-shift-from-bipolar-disorder-to-schizoaffective-disorder
#14
Lucas Argolo, Fabrício Batista, Severino Bezerra-Filho, Flávio Kapczinski, Ângela Miranda-Scippa
OBJECTIVE: To describe three cases of diagnostic shift from bipolar I disorder (BD) to schizoaffective disorder (SAD). METHODS: BD patients were clinically assessed and followed up in a mood disorder program. A questionnaire was applied to assess clinical and socio-demographic characteristics, and a Structured Clinical Interview (SCID-I) was conducted. RESULTS: We identified three patients with diagnosis conversion to SAD from 2005 to 2016...
November 30, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29188734/psychiatric-axis-i-and-personality-axis-ii-disorders-and-subjective-psychiatric-symptoms-in-chronic-tinnitus
#15
Hanna Sahlsten, Tero Taiminen, Max Karukivi, Noora Sjösten, Johanna Nikkilä, Juuso Virtanen, Janika Paavola, Juho Joutsa, Katri Niinivirta-Joutsa, Mari Takala, Anu Holm, Esa Rauhala, Eliisa Löyttyniemi, Reijo Johansson, Satu K Jääskeläinen
OBJECTIVE: Chronic tinnitus has been associated with several psychiatric disorders. Only few studies have investigated these disorders using validated diagnostic interviews. The aims were to diagnose psychiatric and personality disorders with structured interviews, to assess self-rated psychiatric symptoms and elucidate temporal relations between psychiatric disorders and tinnitus. DESIGN: Current and lifetime DSM-IV diagnoses of axis-I (psychiatric disorders) and axis-II (personality disorders) were assessed using structured clinical interviews (SCID-I and -II)...
November 30, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/29186204/mocetinostat-combined-with-gemcitabine-for-the-treatment-of-leiomyosarcoma-preclinical-correlates
#16
Gonzalo Lopez, Danielle Braggio, Abeba Zewdu, Lucia Casadei, Kara Batte, Hemant Kumar Bid, David Koller, Peter Yu, Obiajulu Hans Iwenofu, Anne Strohecker, Edwin Choy, Dina Lev, Raphael Pollock
Leiomyosarcoma (LMS) is a malignant soft tissue sarcoma (STS) with a dismal prognosis following metastatic disease. Chemotherapeutic intervention has demonstrated to have modest clinical efficacy with no curative potential in LMS patients. Previously, we demonstrated pan-HDAC inhibition to have a superior effect in various complex karyotypic sarcomas. In this study, our goal is to evaluate the therapeutic efficacy of mocetinostat alone and in combination with gemcitabine in LMS. Human leiomyosarcoma (LMS) cell lines were used for in vitro and in vivo studies...
2017: PloS One
https://www.readbyqxmd.com/read/29186169/epidemiology-of-severe-mental-illness-in-hunan-province-in-central-china-during-2014-2015-a-multistage-cross-sectional-study
#17
Dongxin Wang, Jing Ma, Lihong Tan, Yan Chen, Xiaosong Li, Xuefei Tian, Xuhui Zhou, Xuejun Liu
OBJECTIVE: Severe mental illness (SMI) represents major social and public health problem in China, especially in low- or middle-income regions. We aim to assess the prevalence and distribution of SMI in Hunan province in central China. METHODS: Multistage stratified random sampling methods were used to select qualified subjects in 123 districts and counties in Hunan province. 89465 individuals were randomly identified, and 72999 (81.6%) completed the supplemental 12-Item General Health Questionnaire (GHQ-12) and Cue questionnaire of psychiatric abnormal behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/29185897/pharmacological-treatment-of-insomnia-symptoms-in-individuals-with-substance-use-disorders-in-spain-a-quasi-experimental-study
#18
L Grau-López, L Grau-López, C Daigre, R F Palma-Álvarez, L Rodriguez-Cintas, E Ros-Cucurull, C Roncero
INTRODUCTION: Pharmacological treatment of insomnia in patients with addictions has been hardly investigated and there are few researches about it in an inpatient detoxification. The aim of this study was to describe the outcomes of the pharmacological treatment of insomnia in SUD patients admitted to a detoxification unit in Spain, with a focus on the primary substance of abuse and co-occurring mental disorders. METHODS: A quasi-experimental study was conducted in 481 addicted in patients, who were admitted for substances detoxification in Vall d´Hebron University Hospital, Barcelona, Spain, from 2010 to 2015...
November 29, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29178470/lymphocyte-independent-pathways-underlie-the-pathogenesis-of-murine-cytomegalovirus-associated-secondary-hemophagocytic-lymphohistiocytosis
#19
Brisse Ellen, Imbrechts Maya, Mitera Tania, Vandenhaute Jessica, Berghmans Nele, Boon Louis, Wouters H Carine, Snoeck Robert, Andrei Graciela, Matthys Patrick
Hemophagocytic lymphohistiocytosis (HLH) constitutes a spectrum of immunological disorders characterized by uncontrolled immune activation and key symptoms such as fever, splenomegaly, pancytopenia, hemophagocytosis, hyperferritinemia and hepatitis. In genetic or primary HLH, hyperactivated CD8+ T cells are the main drivers of pathology. However, in acquired, secondary HLH, the role of lymphocytes remains vague. In the present study the involvement of lymphocytes in the pathogenesis of a cytomegalovirus-induced model of secondary HLH was explored...
November 27, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29175555/pharmacokinetics-of-doxorubicin-in-glioblastoma-multiforme-following-ultrasound-induced-blood-brain-barrier-disruption-as-determined-by-microdialysis
#20
Yi-Li Lin, Meng-Ting Wu, Feng-Yi Yang
The goal of this study was to investigate the in vivo extracellular kinetics of doxorubicin (Dox) in glioblastoma multiforme (GBM)-bearing mice following focused ultrasound (FUS)-induced blood-brain barrier (BBB) disruption using microdialysis. An intracranial brain tumor model in NOD-scid mice using human brain GBM 8401 cells was used in this study. Prior to each sonication, simultaneous intravenous administration of Dox and microbubbles, and the Dox concentration in the brains was quantified by high performance liquid chromatography (HPLC)...
November 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
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