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T2 mapping

Natasha McDonald, Peter J Eddowes, James Hodson, Scott I K Semple, Nigel P Davies, Catherine J Kelly, Stella Kin, Miranda Phillips, Amy H Herlihy, Timothy J Kendall, Rachel M Brown, Desley A H Neil, Stefan G Hübscher, Gideon M Hirschfield, Jonathan A Fallowfield
LiverMultiScan is an emerging diagnostic tool using multiparametric MRI to quantify liver disease. In a two-centre prospective validation study, 161 consecutive adult patients who had clinically-indicated liver biopsies underwent contemporaneous non-contrast multiparametric MRI at 3.0 tesla (proton density fat fraction (PDFF), T1 and T2* mapping), transient elastography (TE) and Enhanced Liver Fibrosis (ELF) test. Non-invasive liver tests were correlated with gold standard histothological measures. Reproducibility of LiverMultiScan was investigated in 22 healthy volunteers...
June 15, 2018: Scientific Reports
Masashi Suzuki, Atsushi Senoo, Mamoru Niitsu
PURPOSE: To improve imaging, a reliable setup method is critical for the accurate localization of lesions and surface markers. Because an anisotropic marker has not yet been validated for MRI, direct localization of surface markers is not yet feasible in fractional anisotropy (FA) maps. This study aimed to develop an anisotropic surface marker using wood for an FA map and to determine whether a wood marker is useful for various sequences. METHODS: Wood infiltrated with water was used to develop an anisotropic surface marker...
June 13, 2018: Magnetic Resonance in Medical Sciences: MRMS
Jing Liu, Zheng Han, Guoli Chen, Yuguo Li, Jia Zhang, Jiadi Xu, Peter C M van Zijl, Shuixing Zhang, Guanshu Liu
Sepsis-induced acute kidney injury (SAKI) is a major complication of kidney disease associated with increased mortality and faster progression. Therefore, the development of imaging biomarkers to detect septic AKI is of great clinical interest. In this study, we aimed to characterize the endogenous chemical exchange saturation transfer (CEST) MRI contrast in the lipopolysaccharide (LPS)-induced SAKI mouse model and to investigate the use of CEST MRI for detecting such injury. We used a SAKI mouse model that was generated by i...
June 13, 2018: NMR in Biomedicine
Aaron H Carter, Nicholas Guttierez, Ty K Subhawong, H T Temple, Bryson P Lesniak, Michael G Baraga, Jean Jose
Objectives: BioCartilage is a novel scaffold-based microfracture augmentation technique that has been shown to aid in chondrogenic differentiation of adult progenitor cells resulting in formation of more hyaline-like cartilage. As this cartilage repair technique becomes more commonplace, it is essential that the musculoskeletal radiologist and orthopedic surgeon gain familiarity with the surgical technique and its post-operative MR imaging findings. Methods: We present several case studies regarding MRI findings (modified clinical 2D MOCART) and clinical outcome (KOOS) scores in patients who have undergone this novel surgical procedure...
April 2018: Journal of Clinical Orthopaedics and Trauma
G Shapira-Zaltsberg, D Grynspan, M V Quintana, P C Dominguez, D Reddy, J H Davila, E Miller
AIM: To investigate if magnetic resonance imaging (MRI) features of the placenta are different in fetuses with and without central nervous system (CNS) abnormalities. MATERIAL AND METHODS: Institutional research ethics board approval was obtained. Fetal MRI of 97 singleton pregnancies were analysed retrospectively (19-25 weeks gestation), 65 with CNS morphological abnormalities and 32 controls. Placental T2 signal intensity, placental and fetal volumes, placental-to-fetal volume ratio, and placental apparent diffusion coefficient (ADC) values were assessed...
June 9, 2018: Clinical Radiology
Mokhtar Mars, Mouna Bouaziz, Zeineb Tbini, Fethi Ladeb, Souha Gharbi
OBJECTIVE: This study aims to determine how Magnetic Resonance Imaging (MRI) acquisition techniques and calculation methods affect T2 values of knee cartilage at 1.5 Tesla and to identify sequences that can be used for high-resolution T2 mapping in short scanning times. MATERIALS AND METHODS: This study was performed on phantom and twenty-nine patients who underwent MRI of the knee joint at 1.5 Tesla. The protocol includes T2 mapping sequences based on Single Echo Spin Echo (SESE), Multi-Echo Spin Echo (MESE), Fast Spin Echo (FSE) and Turbo Gradient Spin Echo (TGSE)...
June 12, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Laurentius Huber, Desmond H Y Tse, Christopher J Wiggins, Kâmil Uludağ, Sriranga Kashyap, David C Jangraw, Peter A Bandettini, Benedikt A Poser, Dimo Ivanov
Functional mapping of cerebral blood volume (CBV) changes has the potential to reveal brain activity with high localization specificity at the level of cortical layers and columns. Non-invasive CBV imaging using Vascular Space Occupancy (VASO) at ultra-high magnetic field strengths promises high spatial specificity but poses unique challenges in human applications. As such, 9.4 T B1 + and B0 inhomogeneities limit efficient blood tagging, while the specific absorption rate (SAR) constraints limit the application of VASO-specific RF pulses...
June 8, 2018: NeuroImage
Hongyue Tao, Yang Qiao, Yiwen Hu, Yuxue Xie, Rong Lu, Xu Yan, Shuang Chen
Objectives: To quantitatively assess changes in cartilage matrix after acute anterior cruciate ligament (ACL) rupture using T2- and T2⁎ -mapping and analyze the correlation between the results of both methods. Methods: Twenty-three patients and 23 healthy controls were enrolled and underwent quantitative MRI examination. The knee cartilage was segmented into six compartments, including lateral femur (LF), lateral tibia (LT), medial femur (MF), medial tibia (MT), trochlea (Tr), and patella (Pa)...
2018: BioMed Research International
M Gastl, P Behm, S Haberkorn, L Holzbach, V Veulemans, C Jacoby, B Schnackenburg, T Zeus, M Kelm, F Bönner
BACKGROUND: Patients with severe aortic stenosis (AS) are subjected to left ventricular hypertrophy (LVH) with increasing morbidity and mortality. Transcatheter aortic valve replacement (TAVR) induces reverse left ventricular remodeling which can be monitored by cardiovascular magnetic resonance (CMR). CMR is able to analyze myocardial tissue properties by magnetic relaxation times (parametric CMR). The objective of this study was to study myocardial T2 relaxation in reverse ventricular remodeling after TAVR...
September 1, 2018: International Journal of Cardiology
Thorsten Brechmann, Christoph Maier, Miriam Kaisler, Jan Vollert, Wolff Schmiegel, Svetlana Pak, Norbert Scherbaum, Fred Rist, Andrea Riphaus
Background: Propofol is recommended for sedation in gastrointestinal endoscopy (GE), but preliminary data suggest addictive potentials. Objective: The objective of this article is to evaluate the frequency of predominantly euphoric reaction after GE and patients' subsequent reminiscences. Methods: Eighty-two patients undergoing elective GE under propofol sedation were enrolled in a prospective observational study. The grade of anxiety, expectation or relief about the examination's result and affective state in terms of cheerfulness, relaxation, activation, sedation and anxiety were surveyed using a numeric rating scale (1 to 10) immediately before (t1), after GE (t2) and seven days (t3) later...
May 2018: United European Gastroenterology Journal
Elias Yla-Herttuala, Svetlana Laidinen, Hanne Laakso, Timo Liimatainen
BACKGROUND: Two days after myocardial infarction (MI), the infarct consists mostly on necrotic tissue, and the myocardium is transformed through granulation tissue to scar in two weeks after the onset of ischemia in mice. In the current work, we determined and optimized cardiovascular magnetic resonance (CMR) methods for the detection of MI size during the scar formation without contrast agents in mice. METHODS: We characterized MI and remote areas with rotating frame relaxation time mapping including relaxation along fictitious field in nth rotating frame (RAFFn), T1ρ and T2 relaxation time mappings at 1, 3, 7, and 21 days after MI...
June 7, 2018: Journal of Cardiovascular Magnetic Resonance
Koshi Ota, Ryo Iida, Kanna Ota, Masahide Sakaue, Shogo Takashima, Kohei Taniguchi, Masao Tomioka, Masahiko Nitta, Akira Takasu
INTRODUCTION: The abrupt onset of sensorimotor deficits is a neurologic emergency that requires immediate management. Acute spontaneous spinal cord infarction (SCI) is rare, but can cause the sudden onset of quadriplegia or quadriparesis. Magnetic resonance imaging (MRI) is an essential imaging modality to diagnose SCI. CASE PRESENTATION: A 75-year-old man with a history of diabetes mellitus type 2, hypertension, and dyslipidemia was transferred to our facility for further workup of the sudden onset of quadriplegia...
June 2018: Medicine (Baltimore)
Koji Murakami, Yuji Arai, Kazuya Ikoma, Kammei Kato, Hiroaki Inoue, Shuji Nakagawa, Yuta Fujii, Keiichiro Ueshima, Hiroyoshi Fujiwara, Toshikazu Kubo
The aim of this study was to perform quantitative evaluation of degeneration of joint cartilage using T2 mapping in magnetic resonance imaging (MRI) after arthroscopic partial resection of the lateral meniscus.The subjects were 21 patients (23 knees) treated with arthroscopic partial resection of the lateral meniscus. MRI was performed for all knees before surgery and 6 months after surgery to evaluate the center of the lateral condyle of the femur in sagittal images for T2 mapping. Ten regions of interest (ROIs) on the articular cartilage were established at 10-degree intervals, from the point at which the femur shaft crossed the lateral femoral condyle joint to the articular cartilage 90° relative to the femur shaft...
June 2018: Medicine (Baltimore)
Mahdi Alizadeh, Joshua Fisher, Sona Saksena, Yusra Sultan, Chris J Conklin, Devon M Middleton, Laura Krisa, Jürgen Finsterbusch, Adam E Flanders, Scott H Faro, M J Mulcahey, Feroze B Mohamed
Background and objective: Diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) are two techniques that can measure white matter integrity of the spinal cord. Recently, DTI indices have been shown to change with age. The purpose of this study is (a) to evaluate the maturational states of the entire pediatric spinal cord using DTI and DTT indices including fractional anisotropy (FA), mean diffusivity (MD), mean length of white matter fiber tracts and tract density and (b) to analyze the DTI and DTT parameters along the entire spinal cord as a function of spinal cord levels and age...
2018: NeuroImage: Clinical
Samantha Grossmith, Anvy Nguyen, Jiani Hu, Jennifer K Plichta, Faina Nakhlis, Linda Cutone, Laura Dominici, Mehra Golshan, Margaret Duggan, Katharine Carter, Esther Rhei, Thanh Barbie, Katherina Calvillo, Suniti Nimbkar, Jennifer Bellon, Julia Wong, Rinaa Punglia, William Barry, Tari A King
BACKGROUND: The after mapping of the axilla: radiotherapy or surgery (AMAROS) trial concluded that for patients with cT1-2 N0 breast cancer and one or two positive sentinel lymph nodes (SLNs), axillary radiotherapy (AxRT) provides equivalent locoregional control and a lower incidence of lymphedema compared with axillary lymph node dissection (ALND). The study prospectively assessed how often ALND could be replaced by AxRT in a consecutive cohort of patients undergoing mastectomy for cT1-2 N0 breast cancer...
June 4, 2018: Annals of Surgical Oncology
Lucidio P Nunes Neto, Guillaume Madelin, Terlika Pandit Sood, Chih-Chun Wu, Douglas Kondziolka, Dimitris Placantonakis, John G Golfinos, Andrew Chi, Rajan Jain
PURPOSE: Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical application. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measurements to evaluate gliomas...
June 3, 2018: Neuroradiology
Maria Antonietta Bali, Serena Pullini, Thierry Metens, Julie Absil, Shih-Li Chao, Raphael Marechal, Celso Matos, Bibi Mooneera Peerboccus, Jean-Luc Van Laethem
PURPOSE: To prospectively assess chemotherapy-induced changes in pancreatic ductal adenocarcinoma (PDA) with diffusion-weighted (DW)-MR quantitative metrics, including apparent diffusion coefficient (ADC) and histogram-derived parameters, compared with RECIST 1.1. METHODS: 24 patients underwent DW-MR at baseline, week-2 and week-8 after chemotherapy initiation. Tumour diameter was assessed on T2-weighted images. Regions-of-interest (ROI) were drawn on ADC map for ROI-ADC...
July 2018: European Journal of Radiology
Anna Altermatt, Laura Gaetano, Stefano Magon, Dieter A Häring, Davorka Tomic, Jens Wuerfel, Ernst-Wilhelm Radue, Ludwig Kappos, Till Sprenger
There is a limited correlation between white matter (WM) lesion load as determined by magnetic resonance imaging and disability in multiple sclerosis (MS). The reasons for this so-called clinico-radiological paradox are diverse and may, at least partly, relate to the fact that not just the overall lesion burden, but also the exact anatomical location of lesions predict the severity and type of disability. We aimed at studying the relationship between lesion distribution and disability using a voxel-based lesion probability mapping approach in a very large dataset of MS patients...
May 29, 2018: Brain Topography
J Doerner, L Eichhorn, J A Luetkens, J N Lunkenheimer, J Albers, J Nadal, H H Schild, C P Naehle
BACKGROUND: Prolonged apnea by breath-hold (BH) divers leads to hypoxemia and compensatory mechanisms of the cardiovascular system (i.e. increase of total peripheral resistance, increase of systolic blood-pressure, left-ventricular enlargement) to maintain oxygen supply to oxygen sensitive organs such as the brain. All these changes may result in structural myocardial or subclinical brain alterations. Therefore, the aim of this study was to investigate mid-term effects of repetitive prolonged apnea using cardiac magnetic resonance imaging (CMR) and magnetic resonance imaging of the brain...
June 2018: European Journal of Radiology
Haikun Qi, Jie Sun, Huiyu Qiao, Xihai Zhao, Rui Guo, Niranjan Balu, Chun Yuan, Huijun Chen
PURPOSE: To propose a technique that can produce different T1 and T2 contrasts in a single scan for simultaneous T1 and T2 mapping of the carotid plaque (SIMPLE). METHODS: An interleaved 3D golden angle radial trajectory was used in conjunction with T2 preparation with variable duration (TEprep ) and inversion recovery pulses. Sliding window reconstruction was adopted to reconstruct images at different inversion delay time and TEprep for joint T1 and T2 fitting...
May 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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