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https://www.readbyqxmd.com/read/28923036/safety-of-intravenously-applied-mistletoe-extract-results-from-a-phase-i-dose-escalation-study-in-patients-with-advanced-cancer
#1
Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger, Wilfried Tröger
BACKGROUND: Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited. METHODS: An aqueous extract from pine-mistletoe was used to investigate maximum tolerable dose (MTD) and safety of intravenous application. It was infused once weekly for 3 weeks in patients with advanced cancer. Any type of cancer was included; relevant exclusion criteria were concurrent chemo- or radiation therapy...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28853091/biodistribution-of-viscumin-after-subcutaneous-injection-to-mice-and-in-vitro-modeling-of-endoplasmic-reticulum-stress
#2
D V Maltseva, N A Krainova, N A Khaustova, S V Nikulin, S A Tonevitskaya, A A Poloznikov
Viscumin (mistletoe lectin I, MLI) in concentrations of 10(-11)-10(-7) M causes endoplasmic reticulum stress and triggers unfolded protein response, a modulator of antitumor immunity, in target cells.
August 29, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28791312/synergistic-antitumour-properties-of-viscumtt-in-alveolar-rhabdomyosarcoma
#3
Rahel Mascha Stammer, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Aqueous mistletoe extracts from the European mistletoe (Viscum album) contain mainly mistletoe lectins and viscotoxins as cytotoxic compounds. Lipophilic triterpene acids, which do not occur in conventional mistletoe preparations, were solubilised with β-cyclodextrins. The combination of an aqueous extract (viscum) and a triterpene-containing extract (TT) recreated a whole mistletoe extract (viscumTT). These extracts were tested on rhabdomyosarcoma in vitro, ex vivo, and in vivo with regard to anticancer effects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28719632/viscum-album-neutralizes-tumor-induced-immunosuppression-in-a-human-in-vitro-cell-model
#4
Carmen Steinborn, Amy Marisa Klemd, Ann-Sophie Sanchez-Campillo, Sophie Rieger, Marieke Scheffen, Barbara Sauer, Manuel Garcia-Käufer, Konrad Urech, Marie Follo, Annekathrin Ücker, Gunver Sophia Kienle, Roman Huber, Carsten Gründemann
Tumor cells have the capacity to secrete immunosuppressive substances in order to diminish dendritic cell (DC) activity and thereby escape from immune responses. The impact of mistletoe (Viscum album) extracts (VAE), which are frequently used as an additive anti-cancer therapy to stimulate the immune response, is still unknown. Using a human cellular system, the impact of two different VAE (VAEA + VAEI) on the maturation of human dendritic cells and on T cell function has been investigated using flow cytometry, automated fluorescence microscopy and cytokine bead array assays...
2017: PloS One
https://www.readbyqxmd.com/read/28689799/cardioprotective-effects-of-viscum-album-l-subsp-album-european-misletoe-leaf-extracts-in-myocardial-ischemia-and-reperfusion
#5
Eylem Suveren, Gary F Baxter, Alper B Iskit, Arzu Ucar Turker
ETHNOPHARMACOLOGICAL RELEVANCE: Viscum album L. (European mistletoe) is a hemiparasitic plant belonging to Loranthaceae family and has been used in Turkish traditional medicine for the treatment of cardiovascular disorders and heart diseases such as hypertension, tachycardia and angina pectoris. AIM OF THE STUDY: The present study investigated the cardioprotective effects of V. album leaf extracts in myocardial ischemia and reperfusion injury in rats. MATERIAL AND METHODS: Lyophilized aqueous (AVa) and methanolic (MVa) extracts of V...
July 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28676664/itraq-based-quantitative-proteomic-analysis-of-the-inhibitory-effects-of-polysaccharides-from-viscum-coloratum-kom-nakai-on-hepg2-cells
#6
Yangyang Chai, Min Zhao
Viscum coloratum (Kom.) Nakai is one of active medicinal plants, and its active components, especially polysaccharides, have been shown to exhibit bioactivity. In this study, we examined the effects of three polysaccharide fractions from Viscum coloratum (Kom.) Nakai on HepG2 cell growth in a dose-dependent manner by using a CCK-8 assay kit. Flow cytometry analysis showed that VCP2 treatment delayed the cell cycle in the G1 phase and induced apoptosis in HepG2 cells, a result possibly due to the increased expression of p21(Wafl/Cip1) and Cyclin D and the decreased expression of Cyclin E and CDK4...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28642934/evaluation-of-the-antibacterial-and-antifungal-properties-of-phragmanthera-capitata-sprengel-balle-loranthaceae-a-mistletoe-growing-on-rubber-tree-using-the-dilution-techniques
#7
Franklin Uangbaoje Ohikhena, Olubunmi Abosede Wintola, Anthony Jide Afolayan
The alarming increase in multidrug resistance of pathogenic microorganisms to conventional drugs in recent years has prompted the search for new leads in alternative remedies in natural products. Hence, this study was aimed at evaluating the antimicrobial properties of Phragmanthera capitata, a parasitic mistletoe growing on rubber trees. The in vitro antimicrobial activities of the acetone, methanol, ethanol, and aqueous extracts were investigated using five gram-negative and five gram-positive bacteria and four fungi...
2017: TheScientificWorldJournal
https://www.readbyqxmd.com/read/28640163/mistletoe-fig-ficus-deltoidea-jack-leaf-extract-prevented-postmenopausal-osteoarthritis-by-attenuating-inflammation-and-cartilage-degradation-in-rat-model
#8
Nur Adeelah Che Ahmad Tantowi, Paisal Hussin, Seng Fong Lau, Suhaila Mohamed
OBJECTIVE: Ficus deltoidea Jack (mistletoe fig) is an ornamental plant found in various parts of the world and used as traditional herbal medicine in some countries. This study investigated the potential use of F deltoidea leaf extract to mitigate osteoarthritis (OA) in ovariectomized (estrogen-deficient postmenopausal model) rats and the mechanisms involved. Diclofenac was used for comparison. METHODS: Sprague-Dawley female rats (12 weeks old) were divided randomly into five groups (n = 6): healthy; nontreated OA; OA + diclofenac (5 mg/kg); OA + extract (200 mg/kg); and OA + extract (400 mg/kg)...
September 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28634588/antitumor-effect-of-kml-b-treated-dendritic-cells-via-induction-of-lymphocyte-activation
#9
Jong-Jin Kim, Yun-Ho Hwang, Kyung-Yun Kang, Sung-Ju Lee, Jong-Bae Kim, Jina Choi, Sung-Tae Yee
Lectins are carbohydrate-binding proteins with various biological activities, such as antitumor and immunomodulatory effects. Although lectins have various biological activities, they are still limited by cytotoxicity in normal cells. To overcome this problem, we used the noncytotoxic part of Korean mistletoe lectin B-chain (KML-B) to induce maturation of dendritic cells (DCs). A previous study reported that KML-B induces DC maturation by triggering TLR-4, including expression of costimulatory molecules (CD40, CD80, and CD86), MHC II, and secretion of cytokines in DCs...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28596809/viscum-album-l-in-experimental-animal-tumors-a-meta-analysis
#10
Leoni Villano Bonamin, Aloisio Cunha de Carvalho, Silvia Waisse
Mistletoe (Viscum album L.) has been used as complementary anticancer treatment for ~100 years. Although the clinical efficacy of mistletoe in cancer and associated survival benefits remain contested, several studies point to its effectiveness and others have reported antitumor and immunomodulatory properties. In the present review, a search was conducted for original articles reporting the outcomes of treatments for experimental animal tumors with mistletoe. The inclusion criteria were: Publication in English, from 1996 onwards and in peer-reviewed journals included in the database PubMed...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28571969/proteomic-fingerprinting-of-mistletoe-viscum-album-l-via-combinatorial-peptide-ligand-libraries-and-mass-spectrometry-analysis
#11
María Vergara-Barberán, María Jesús Lerma-García, Maria Nicoletti, Ernesto Francisco Simó-Alfonso, José Manuel Herrero-Martínez, Elisa Fasoli, Pier Giorgio Righetti
Combinatorial peptide ligand libraries (CPLLs), coupled to mass spectrometry (MS) analysis, have been used to investigate in depth the proteome of Viscum album L. (VA), commonly named European mistletoe, in order to provide a first proteomic fingerprinting. For this purpose, the proteins were captured via CPLLs at two different pH values (acidic and neutral). A total of 648 non-redundant proteins were identified by using two different databases. The two pH values, chosen for bead incubations, have contributed to increment the capture ability: 56% and 31% of CPLLs species were respectively recognized at pH7...
May 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28533204/diverse-early-dwarf-mistletoes-arceuthobium-ecological-keystones-of-the-eocene-baltic-amber-biota
#12
Eva-Maria Sadowski, Leyla J Seyfullah, Carol A Wilson, Clyde L Calvin, Alexander R Schmidt
PREMISE OF THE STUDY: Extant dwarf mistletoes (Arceuthobium M. Bieb., Viscaceae) are hemiparasites with complex roles in nature. They are one of the most severe pests in northern hemisphere conifer forests, but they also enhance the structural complexity and species diversity of the forests. Here, we describe the first pre-Miocene macrofossils of dwarf mistletoes. The fossils from Eocene Baltic amber provide new insights into the morphological evolution of the Arceuthobium lineage and its paleobiogeography...
May 21, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28467981/-methotrexate-induced-nephrotoxicity-in-rats-protective-effect-of-mistletoe-viscum-album-l-extract
#13
Esin Sakalli Çetin, Hasan Tetiker, Özgür İlhan Çelik, Nigar Yılmaz, İbrahim Hakkı Ciğerci
No abstract text is available yet for this article.
May 4, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28466378/a-native-parasitic-plant-systemically-induces-resistance-in-jack-pine-to-a-fungal-symbiont-of-invasive-mountain-pine-beetle
#14
Jennifer G Klutsch, Ahmed Najar, Patrick Sherwood, Pierluigi Bonello, Nadir Erbilgin
Conifer trees resist pest and pathogen attacks by complex defense responses involving different classes of defense compounds. However, it is unknown whether prior infection by biotrophic pathogens can lead to subsequent resistance to necrotrophic pathogens in conifers. We used the infection of jack pine, Pinus banksiana, by a common biotrophic pathogen dwarf mistletoe, Arceuthobium americanum, to investigate induced resistance to a necrotrophic fungus, Grosmannia clavigera, associated with the mountain pine beetle, Dendroctonus ponderosae...
May 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28454538/transcriptomic-and-proteomic-insight-into-the-effects-of-a-defined-european-mistletoe-extract-in-ewing-sarcoma-cells-reveals-cellular-stress-responses
#15
M Twardziok, D Meierhofer, S Börno, B Timmermann, S Jäger, Sengül Boral, A Eggert, C I Delebinski, G Seifert
BACKGROUND: The hydrophobic triterpenes, oleanolic and betulinic acid as well as the hydrophilic mistletoe lectins and viscotoxins possess anticancer properties. They do all occur in combination in European mistletoe (Viscum album L.). Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We have previously shown that mistletoe lectins and triterpene acids are effective against Ewing sarcoma in vitro, ex vivo and in vivo. METHODS: We recreated a total mistletoe effect (viscumTT) by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilised with cyclodextrins and analysed the effects of viscumTT and the single extracts on TC-71 Ewing sarcoma cells in vitro by transcriptomic and proteomic profiling...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28417943/lc-esi-ms-ms-identification-of-biologically-active-phenolic-compounds-in-mistletoe-berry-extracts-from-different-host-trees
#16
Wioleta Pietrzak, Renata Nowak, Urszula Gawlik-Dziki, Marta Kinga Lemieszek, Wojciech Rzeski
A new, rapid, sensitive and selective liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) method was developed to determine the content of flavonoid aglycones and phenolic acids in mistletoe berries (Viscum album L.) harvested from six different Polish host trees. Additionally, the total phenolic content (TPC) and total flavonoid content (TFC) as well as an antioxidant and antiproliferative activity were evaluated for the first time. The plant material was selectively extracted using ultrasound assisted maceration with methanol/water (8:2) solution...
April 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28349942/frugivore-mediated-selection-in-a-habitat-transformation-scenario
#17
Francisco E Fontúrbel, Rodrigo Medel
Plant-animal interactions are strong drivers of phenotypic evolution. However, the extent to which anthropogenic habitat transformation creates new selective scenarios for plant-animal interactions is a little explored subject. We examined the effects of native forest replacement by exotic Eucalyptus trees on the frugivore-mediated phenotypic selection coefficients imposed by the relict marsupial Dromiciops gliroides upon traits involved in frugivore attraction and germination success of the mistletoe Tristerix corymbosus (Loranthaceae)...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28338947/microenvironment-in-the-canopy-rivals-the-host-tree-water-status-in-controlling-sap-flow-of-a-mistletoe-species
#18
Da Yang, Guillermo Goldstein, Miao Wang, Wei-Wei Zhang, Ai-Ying Wang, Yan-Yan Liu, Guang-You Hao
Mistletoes absorb water from the vascular system of their hosts and thus the water use of mistletoes can be influenced by the water status of their hosts besides abiotic environmental conditions; however, there is a lack of studies on the dynamics of mistletoe water utilization in relation to both types of controlling factors. By building a canopy platform at 20 m above the ground, we monitored the dynamic changes of sap flow of Viscum coloratum (Kom.) Nakai (Loranthaceae) in combination with continuous measurements of microclimatic variables and volumetric water content (VWC) of its host tree branch xylem...
April 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28338758/mistletoe-infestation-mediates-alteration-of-the-phytohormone-profile-and-anti-oxidative-metabolism-in-bark-and-wood-of-its-host-pinus-sylvestris
#19
Bin Hu, Hitoshi Sakakibara, Yumiko Takebayashi, Franziska S Peters, Jörg Schumacher, Monika Eiblmeier, Leila Arab, Jürgen Kreuzwieser, Andrea Polle, Heinz Rennenberg
European mistletoe (Viscum album L.) has largely infested Central European forests and causes high mortality probability particularly in dry years. However, little information is available about the consequences of mistletoe infestation for metabolic processes in bark and wood of its host, despite their important roles in infestation defense. We analyzed the tissue hydration, carbohydrate composition, phytohormone profile, reactive oxygen species and anti-oxidant levels in bark and wood of Scots pines (Pinus sylvestris L...
May 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28316788/chemical-pleurodesis-using-mistletoe-extracts-via-spray-catheter-during-medical-thoracoscopy-for-management-of-malignant-pleural-effusion
#20
Jung Seop Eom, Tae Hwa Kim, Geewon Lee, Hyo Yeong Ahn, Jeong Ha Mok, Min Ki Lee
We present three cases of successful chemical pleurodesis with a liquid solution of mistletoe extract using a spray catheter during medical thoracoscopy. The medical thoracoscopy was performed in all presented cases to remove pleural effusion and conduct chemical pleurodesis to manage symptomatic malignant pleural effusion. A spray catheter was used to instil the mistletoe extract evenly into the pleural cavity, and there were no pleurodesis-related complications. Respiratory symptoms caused by pleural effusion improved after pleurodesis, and successful pleurodesis was maintained for more than 3 months after medical thoracoscopy in all three patients...
May 2017: Respirology Case Reports
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