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https://www.readbyqxmd.com/read/29285722/determination-of-heavy-metals-in-almonds-and-mistletoe-as-a-parasite-growing-on-the-almond-tree-using-icp-oes-or-icp-ms
#1
Veysi Kamar, Rukiye Dağalp, Mustafa Taştekin
In this study, the elements of Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Ni, Sr, Pb, Ti, and Zn were determined in the leaves, fruits, and branches of mistletoe, (Viscum albüm L.), used as a medicinal plant, and in the leaves, branches and barks of almond tree which mistletoe grows on. The aim of the study is to investigate whether the mistletoe are more absorbent than the almond tree in terms of the heavy metal contents and the determination of the amount of the elements penetrated into the mistletoe from the almond tree...
December 28, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29237435/clinical-safety-of-combined-therapy-of-immune-checkpoint-inhibitors-and-viscum-album-l-therapy-in-patients-with-advanced-or-metastatic-cancer
#2
Anja Thronicke, Megan L Steele, Christian Grah, Burkhard Matthes, Friedemann Schad
BACKGROUND: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and within integrative and anthroposophical concepts with the goal to improve quality of life. The primary objective of this pilot observational cohort study was to determine the rate of adverse events (AE) related to ICM therapy with and without VA in patients with advanced or metastatic cancer in a certified Cancer Center...
December 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29222720/reproductive-ecology-of-a-parasitic-plant-differs-by-host-species-vector-interactions-and-the-maintenance-of-host-races
#3
Kelsey M Yule, Judith L Bronstein
Parasitic plants often attack multiple host species with unique defenses, physiology, and ecology. Reproductive phenology and vectors of parasitic plant genes (pollinators and dispersers) can contribute to or erode reproductive isolation of populations infecting different host species. We asked whether desert mistletoe, Phoradendron californicum (Santalaceae tribe Visceae syn. Viscaceae), differs ecologically across its dominant leguminous hosts in ways affecting reproductive isolation. Parasite flowering phenology on one host species (velvet mesquite, Prosopis velutina) differed significantly from that on four others, and phenology was not predicted by host species phenology or host individual...
December 8, 2017: Oecologia
https://www.readbyqxmd.com/read/29202738/effects-of-mistletoe-products-on-pharmacokinetic-drug-turnover-by-inhibition-and-induction-of-cytochrome-p450-activities
#4
Michael Schink, Oliver Dehus
BACKGROUND: European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe therapy. METHODS: Three European mistletoe products (Helixor® A, Helixor® M and Helixor® P from mistletoe grown on firs, apple trees and pines, respectively) were tested for inhibition of nine major cytochrome P450 (CYP) isoenzymes in a test system using pooled human liver microsomes and for induction of five CYP isoforms in human hepatocytes cultivated in vitro according to the relevant guideline...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29190390/mistletoe-induced-growth-reductions-at-the-forest-stand-scale
#5
Chris Kollas, Martin Gutsch, Robert Hommel, Petra Lasch-Born, Felicitas Suckow
The hemiparasite European mistletoe (Viscum album L.) adversely affects growth and reproduction of the host Scots pine (Pinus sylvestris L.) and in consequence may lead to tree death. Here, we aimed to estimate mistletoe-induced losses in timber yield applying the process-based forest growth model 4C. The parasite was implemented into the eco-physiological forest growth model 4C using (literature-derived) established impacts of the parasite on the tree's water and carbon cycle. The amended model was validated simulating a sample forest stand in the Berlin area (Germany) comprising trees with and without mistletoe infection...
November 28, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29181309/effect-of-mistletoe-combined-with-carboxymethyl-cellulose-on-dry-eye-in-postmenopausal-women
#6
Nan Jiang, Lin-Hong Ye, Lei Ye, Jing Yu, Qi-Chen Yang, Qing Yuan, Pei-Wen Zhu, Yi Shao
AIM: To investigate the protective effect of mistletoe combined with carboxymethyl cellulose eye drops on dry eye in postmenopausal women. METHODS: Sixty postmenopause female patients diagnosed of dry eye were assigned randomly to mistletoe combined with carboxymethyl cellulose eye drops treatment group (n=30) and control group treated with normal saline eye drops (n=30). The subjective symptoms of ocular surface, Ocular Surface Disease Index (OSDI), tear film function tests, tear protein and corneal morphology by confocal scanning microscopy were analyzed before treatment and at 1, 2, 4 and 8wk after treatment respectively...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29157828/immune-related-and-adverse-drug-reactions-to-low-versus-high-initial-doses-of-viscum-album-l-in-cancer-patients
#7
Friedemann Schad, Anja Thronicke, Antje Merkle, Harald Matthes, Megan L Steele
BACKGROUND: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been associated with improved quality of life and a reduction in chemotherapy-related ADRs. Beneficial effects of VA are believed to be related to its immunomodulatory properties. Current guidelines recommend commencing with a low dose and increasing slowly overtime, however, off-label prescribing of high initial doses is common...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157814/mistletoe-viscum-album-extract-targets-axl-to-suppress-cell-proliferation-and-overcome-cisplatin-and-erlotinib-resistance-in-non-small-cell-lung-cancer-cells
#8
Soyoung Kim, Kyung-Chan Kim, ChuHee Lee
BACKGROUND: Mistletoe extract of Visucm album extract (VAE) contains many biologically active components and has been reported to be not only a complementary and alternative medicine, but also a potent therapeutic agent for many types of cancer. PURPOSE: In this study, we examined the effect of VAE on expression and activation of Axl and scrutinized the involvement of Axl in the anti-cancer activity of VAE in parental and chemo-resistant non-small cell lung cancer (NSCLC) cells...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29131136/malignant-pleural-effusions-mistletoe-spray-instead-of-talc-poudrage
#9
Jane A Shaw, Coenraad F N Koegelenberg
No abstract text is available yet for this article.
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29131094/pleurodesis-using-mistletoe-extract-delivered-via-a-spray-catheter-during-semirigid-pleuroscopy-for-managing-symptomatic-malignant-pleural-effusion
#10
Jung Seop Eom, Hyo Yeong Ahn, Jeong Ha Mok, Geewon Lee, Eun-Jung Jo, Mi-Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee
BACKGROUND: Talc poudrage during thoracoscopy is considered the standard procedure for patients with symptomatic malignant pleural effusion (MPE). Until now, no alternative technique other than talc poudrage for pleurodesis during medical thoracoscopy has been proposed. Liquid sclerosants, such as mistletoe extract, have been sprayed evenly into the pleural cavity during semirigid pleuroscopy for chemical pleurodesis. OBJECTIVE: We conducted a retrospective study using the database of semirigid pleuroscopy to identify the usefulness of pleurodesis using a mistletoe extract delivered via a spray catheter during semirigid pleuroscopy for symptomatic MPE...
November 7, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29112983/identification-of-viscum-album-l-mirnas-and-prediction-of-their-medicinal-values
#11
Wenyan Xie, Jacob Adolf, Matthias F Melzig
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its functional compounds have not been well characterized...
2017: PloS One
https://www.readbyqxmd.com/read/29063321/elimination-of-a-viscumin-ferromagnetic-nanoparticles-conjugate-from-the-tumor-nodule-in-mice
#12
D V Maltseva, S V Nikulin, N S Sergeeva, S A Tonevitskaya, D A Sakharov
External magnetic field is characterized by low toxicity and existence of magnetic properties, which contributes to an interest in the development of products from ferromagnetic nanoparticles (FNP) for antitumor therapy. Previously we synthesized a conjugate of ferromagnetic magnetite nanoparticles and viscumin (mistletoe lectin I, MLI), which exhibits the antitumor activity. Studying the pharmacological properties of this conjugate (FNP-MLI) was directed to the evaluation of FNP-MLI elimination after intratumor injection in mice...
October 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29039322/antiviral-activity-of-salidroside-from-the-leaves-of-nigerian-mistletoe-loranthus-micranthus-linn-parasitic-on-hevea-brasiliensis-against-respiratory-syncytial-virus
#13
Matthias Onyebuchi Agbo, Damian Chukwu Odimegwu, Festus Basden Chiedu Okoye, Patience Ogoamaka Osadebe
Isolated Salidroside from the leaves of Nigerian mistletoe (Loranthus micranthus Linn) parasitic on Hevea brasiliensis was evaluated for its antiviral activity against respiratory syncytial virus. Semi- preparative HPLC separation of the ethyl acetate fraction of the leave extract of Loranthus micranthus Linn parasitic on Hevea brasiliensis led to the isolation of a polyphenol. Using spectroscopic methods (1D and 2D NMR and mass spectroscopic data) as well as by comparison with literature data the structure of the compound was determined as 6-O-galloyl salidroside...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28989251/a-hidden-treasure-the-borneo-mistletoes
#14
REVIEW
Ya Chee Lim, Rajan Rajabalaya, Sheba Rani David
The European mistletoe, Viscum album, is the most common consumed adjuvant among cancer patients in Europe. Its success warrants a report on three most apparent mistletoes found in Borneo Island, namely Scurrula ferruginea, Macrosolen cochinchinensis, and Dendrophthoe curvata. The traditional and pharmacological uses of these mistletoes include antibacterial, anticancer, antiviral, antihypertensive, antioxidative, and cytotoxic effects. Phytochemicals such as flavonols, alkaloids, tannins, and gallic acid have been reported in one of these mistletoes...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28960778/a-hemiparasite-in-the-forest-understory-photosynthetic-performance-and-carbon-balance-of-melampyrum-pratense
#15
Petra Světlíková, Tomáš Hájek, Jakub Těšitel
Melampyrum pratense is an annual root-hemiparasitic plant growing mostly in forest understory, an environment with unstable light conditions. While photosynthetic responses of autotrophic plants to variable light conditions are in general well understood, light responses of root hemiparasites have not been investigated. We carried out gas-exchange measurements (light-response and photosynthetic induction curves) to assess the photosynthetic performance of M. pratense in spring and summer. These data and recorded light dynamics data were subsequently used to model carbon balance of the hemiparasite throughout the entire growth season...
September 27, 2017: Plant Biology
https://www.readbyqxmd.com/read/28946886/extract-from-mango-mistletoes-dendrophthoe-pentandra-ameliorates-tnbs-induced-colitis-by-regulating-cd4-t-cells-in-mesenteric-lymph-nodes
#16
Agustina Tri Endharti, Sofy Permana
BACKGROUND: Mango mistletoes Dendrophthoe pentandra (MMDP) extract has attracted interest due to its pharmacological properties, including gastro protective effects. The aim of this study was to investigate whether MMDP extract could increase Foxp3 regulatory T cells and inhibits development of Th17 cells. METHODS: Colitis was induced in Balb/c mice by rectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS). The mice were randomly divided into five groups comprising group1 receiving vehicle (the negative control), group 2-5 receiving TNBS, group 3-5 orally receiving either MMDP extract 150, 300 and 600 mg/kgBW for 7 days after TNBS administration...
September 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28923036/safety-of-intravenously-applied-mistletoe-extract-results-from-a-phase-i-dose-escalation-study-in-patients-with-advanced-cancer
#17
Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger, Wilfried Tröger
BACKGROUND: Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited. METHODS: An aqueous extract from pine-mistletoe was used to investigate maximum tolerable dose (MTD) and safety of intravenous application. It was infused once weekly for 3 weeks in patients with advanced cancer. Any type of cancer was included; relevant exclusion criteria were concurrent chemo- or radiation therapy...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28853091/biodistribution-of-viscumin-after-subcutaneous-injection-to-mice-and-in-vitro-modeling-of-endoplasmic-reticulum-stress
#18
D V Maltseva, N A Krainova, N A Khaustova, S V Nikulin, S A Tonevitskaya, A A Poloznikov
Viscumin (mistletoe lectin I, MLI) in concentrations of 10(-11)-10(-7) M causes endoplasmic reticulum stress and triggers unfolded protein response, a modulator of antitumor immunity, in target cells.
August 29, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28791312/synergistic-antitumour-properties-of-viscumtt-in-alveolar-rhabdomyosarcoma
#19
Rahel Mascha Stammer, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Aqueous mistletoe extracts from the European mistletoe (Viscum album) contain mainly mistletoe lectins and viscotoxins as cytotoxic compounds. Lipophilic triterpene acids, which do not occur in conventional mistletoe preparations, were solubilised with β-cyclodextrins. The combination of an aqueous extract (viscum) and a triterpene-containing extract (TT) recreated a whole mistletoe extract (viscumTT). These extracts were tested on rhabdomyosarcoma in vitro, ex vivo, and in vivo with regard to anticancer effects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28719632/viscum-album-neutralizes-tumor-induced-immunosuppression-in-a-human-in-vitro-cell-model
#20
Carmen Steinborn, Amy Marisa Klemd, Ann-Sophie Sanchez-Campillo, Sophie Rieger, Marieke Scheffen, Barbara Sauer, Manuel Garcia-Käufer, Konrad Urech, Marie Follo, Annekathrin Ücker, Gunver Sophia Kienle, Roman Huber, Carsten Gründemann
Tumor cells have the capacity to secrete immunosuppressive substances in order to diminish dendritic cell (DC) activity and thereby escape from immune responses. The impact of mistletoe (Viscum album) extracts (VAE), which are frequently used as an additive anti-cancer therapy to stimulate the immune response, is still unknown. Using a human cellular system, the impact of two different VAE (VAEA + VAEI) on the maturation of human dendritic cells and on T cell function has been investigated using flow cytometry, automated fluorescence microscopy and cytokine bead array assays...
2017: PloS One
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