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Melatonin and cancer

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https://www.readbyqxmd.com/read/28228077/antioxidant-nanoplatforms-for-dermal-delivery-melatonin
#1
Aroha Belen Sánchez Milán, Ana C Calpena Campmany, Beatriz Clares Naveros
Melatonin (MLT) is emerging as a promising therapeutic agent, mainly due to its role as antioxidant. Substantial evidences show that melatonin is potentially effective on a variety of diseases as cancer, inflammation and neurodegenerative diseases. The excellent antioxidant capacity with pharmacokinetics characteristics and the emerging search for new pharmaceutical nanotechnology based systems, make it particularly attractive to elaborate nanoplatforms based on MLT for biomedical or cosmetic dermal applications...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28214594/association-between-light-at-night-melatonin-secretion-sleep-deprivation-and-the-internal-clock-health-impacts-and-mechanisms-of-circadian-disruption
#2
REVIEW
Yvan Touitou, Alain Reinberg, David Touitou
Exposure to Artificial Light At Night (ALAN) results in a disruption of the circadian system, which is deleterious to health. In industrialized countries, 75% of the total workforce is estimated to have been involved in shift work and night work. Epidemiologic studies, mainly of nurses, have revealed an association between sustained night work and a 50-100% higher incidence of breast cancer.The potential and multifactorial mechanisms of the effects include the suppression of melatonin secretion by ALAN, sleep deprivation, and circadian disruption...
February 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28152213/melatonin-signaling-in-t-cells-functions-and-applications
#3
REVIEW
Wenkai Ren, Gang Liu, Shuai Chen, Jie Yin, Jing Wang, Bie Tan, Guoyao Wu, Fuller W Bazer, Yuanyi Peng, Tiejun Li, Russel J Reiter, Yulong Yin
Melatonin affects a variety of physiological processes including circadian rhythms, cellular redox status and immune function. Importantly, melatonin significantly influences T cell-mediated immune responses, which are crucial to protect mammals against cancers and infections, but are associated with pathogenesis of many autoimmune diseases. This review focuses on our current understanding of the significance of melatonin in T cell biology and the beneficial effects of melatonin in T cell response-based diseases...
February 2, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28151704/urinary-melatonin-in-relation-to-postmenopausal-breast-cancer-risk-according-to-melatonin-1-receptor-status
#4
Elizabeth E Devore, Erica T Warner, Heather Eliassen, Susan B Brown, Andrew H Beck, Susan Hankinson, Eva Schernhammer
BACKGROUND: Urinary melatonin levels have been associated with a reduced risk of breast cancer in postmenopausal women, but this association might vary according to tumor melatonin 1 receptor (MT1R) expression. METHODS: We conducted a nested case-control study among 1,354 postmenopausal women in the Nurses' Health Study, who were cancer free when they provided first-morning spot urine samples in 2000-2002; urine samples were assayed for 6-sulfatoxymelatonin (aMT6s, a major metabolite of melatonin)...
November 9, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28123844/targeting-nf-%C3%AE%C2%BAb-ap-2%C3%AE-signaling-to-enhance-antitumor-activity-of-cisplatin-by-melatonin-in-hepatocellular-carcinoma-cells
#5
Jiaojiao Hao, Zhenglin Li, Changlin Zhang, Wendan Yu, Zhipeng Tang, Yixin Li, Xu Feng, Yue Gao, Quentin Liu, Wenlin Huang, Wei Guo, Wuguo Deng
Cisplatin is a common chemotherapeutic drug for cancer treatment, but its effect is limited because of its cytotoxicity and chemoresistance. The combinational use of cisplatin with some natural compounds has provided a potential option to improve its effect and lower its side effects in cancer treatment. Here, we investigated the role of melatonin in the regulation of cisplatin-mediated antitumor activity in hepatocellular carcinoma cells. The combined treatment of cisplatin with melatonin significantly inhibited cell proliferation and resulted in a corresponding decrease of the IC50 values of cisplatin in four hepatocellular carcinoma cell lines...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28118492/melatonin-prevents-mitochondrial-dysfunction-and-promotes-neuroprotection-by-inducing-autophagy-during-oxaliplatin-evoked-peripheral-neuropathy
#6
Aparna Areti, Prashanth Komirishetty, Manasaveena Akuthota, Rayaz A Malik, Ashutosh Kumar
Oxaliplatin, an organoplatinum compound, is used in the treatment of colorectal cancer, but its clinical use can be limited due to the development of peripheral neuropathy. Whilst mitochondrial dysfunction has been implicated as a major pathomechanism for oxaliplatin-induced neurotoxicity, the prevention of autophagy may also aggravate neuronal cell death. Melatonin, a well-known mitoprotectant and autophagy inducer, was used to examine its neuroprotective role in oxaliplatin-induced peripheral neuropathy (OIPN)...
January 24, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28109165/melatonin-and-sirtuins-a-not-so-unexpected-relationship
#7
REVIEW
Juan C Mayo, Rosa M Sainz, Pedro González Menéndez, Vanesa Cepas, Dun-Xian Tan, Russel J Reiter
Epigenetic modifications, including methylation or acetylation as well as post-transcriptional modifications, are mechanisms used by eukaryotic cells to increase the genome diversity in terms of differential gene expression and protein diversity. Among these modifying enzymes, sirtuins, a class III histone deacetylase (HDAC) enzymes, are of particular importance. Sirtuins regulate the cell cycle, DNA repair, cell survival, and apoptosis, thus having important roles in normal and cancer cells. Sirtuins can also regulate metabolic pathways by changing preference for glycolysis under aerobic conditions as well as glutaminolysis...
January 21, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28103434/analgesic-effect-of-quetiapine-in-a-mouse-model-of-cancer-induced-bone-pain
#8
Mi Hwa Heo, Jin Young Kim, Ilseon Hwang, Eunyoung Ha, Keon Uk Park
Background/Aims: Cancer-induced bone pain (CIBP) is one of the most common pains in patients with advanced neoplasms. Because of treatment-associated side effects, more than half of cancer patients are reported to have inadequate and undermanaged pain control. New mechanism-based therapies must be developed to reduce cancer pain. Quetiapine is a commonly used atypical antipsychotic drug. We report a study of the potential analgesic effects of quetiapine in a mouse model of CIBP and examine the mechanism of bone pain by analyzing the expression of various nociceptors...
January 20, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28099762/human-transporters-pept1-2-facilitate-melatonin-transportation-into-mitochondria-of-cancer-cells-an-implication-of-the-therapeutic-potential
#9
Xiaokui Huo, Chao Wang, Zhenlong Yu, Yulin Peng, Shumei Wang, Shengnan Feng, Shouji Zhang, Xiangge Tian, Chengpeng Sun, Kexin Liu, Sa Deng, Xiaochi Ma
Melatonin is present in virtually all organisms from bacteria to mammals, and it exhibits a broad spectrum of biological functions, including synchronization of circadian rhythms and oncostatic activity. Several functions of melatonin are mediated by its membrane receptors but others are receptor-independent. For the latter, melatonin is required to penetrate membrane and enters intracellular compartments. However, the mechanism by which melatonin enters cells remains debatable. In the current study, it was identified that melatonin and its sulfation metabolites were the substrates of oligopeptide transporter (PEPT) 1/2 and organic anion transporter (OAT) 3, respectively...
January 18, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28063410/the-impact-of-different-extracellular-matrices-on-melatonin-effect-in-proliferation-and-stemness-properties-of-ovarian-cancer-cells
#10
Maryam Akbarzadeh, Reza Rahbarghazi, Elahe Nabat, Ali Akbar Movassaghpour, Daruish Shanehbandi, Behnaz Faramarzian Azimi Maragheh, Danial Matluobi, Balal Barazvan, Masoume Kazemi, Nasser Samadi, Mohammad Nouri
AIM: Endogenous melatonin has numerous physiological roles on modulating the function of different organs. Recent studies revealed oncostatic and protective effects of this molecule on tumor development. In this study, we examined the impact of melatonin and key underlying mechanisms on stemness, morphology, invasiveness and viability of SKOV3 ovarian cancer cells in different types of extracellular matrix. METHODS: Cell viability was evaluated by MTT Assay. Colony-forming assay was performed by seeding 4×10(3) cells on different matrices in six well-plate...
March 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28027652/melatonin-ameliorates-busulfan-induced-spermatogonial-stem-cell-oxidative-apoptosis-in-mouse-testes
#11
Bo Li, Xin He, Mengru Zhuang, Bowen Niu, Chongyang Wu, Hailong Mu, Furong Tang, Yanhua Cui, Weishuai Liu, Baoyu Zhao, Sha Peng, Guangpeng Li, Jinlian Hua
AIMS: Many men endure immunosuppressive or anticancer treatments that contain alkylating agents prior to the age of sexual maturity, especially the increasing number of preadolescent males who undergo busulfan treatment for myeloablative conditioning prior to hematopoietic stem cell transplantation. Prior to sperm production, there are no sperm available for cryopreservation. Thus, it is necessary to identify a solution to ameliorate the busulfan-induced damage of spermatogonial stem cells (SSCs)...
December 27, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28027439/carbamate-insecticides-target-human-melatonin-receptors
#12
Marina Popovska-Gorevski, Margarita L Dubocovich, Rajendram V Rajnarayanan
Carbaryl (1-naphthyl methylcarbamate) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate) are among the most toxic insecticides, implicated in a variety of diseases including diabetes and cancer among others. Using an integrated pharmacoinformatics based screening approach, we have identified these insecticides to be structural mimics of the neurohormone melatonin and were able to bind to the putative melatonin binding sites in MT1 and MT2 melatonin receptors in silico. Carbaryl and carbofuran then were tested for competition with 2-[(125)I]-iodomelatonin (300 pM) binding to hMT1 or hMT2 receptors stably expressed in CHO cells...
February 20, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27997348/relationship-between-plasma-and-salivary-melatonin-and-cortisol-investigated-by-lc-ms-ms
#13
Martijn van Faassen, Rainer Bischoff, Ido P Kema
BACKGROUND: Disturbance of the circadian rhythm has been associated with disease states, such as metabolic disorders, depression and cancer. Quantification of the circadian markers such as melatonin and cortisol critically depend on reliable and reproducible analytical methods. Previously, melatonin and cortisol were primarily analyzed separately, mainly using immunoassays. METHODS: Here we describe the validation and application of a high-throughput liquid chromatography in combination with mass spectrometry (LC-MS/MS) method for the combined analysis of melatonin and cortisol in plasma and saliva...
December 20, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27996309/the-association-between-artificial-light-at-night-and-prostate-cancer-in-gwangju-city-and-south-jeolla-province-of-south-korea
#14
Ka Young Kim, Eunil Lee, Yun Jeong Kim, Jinsun Kim
ABSRACT Exposure to artificial light at night (ALAN) has been reported to be associated with various pathological changes including sleep deprivation, circadian rhythm disruption, and melatonin suppression with increase in various cancers such as breast or prostate cancers. In this study, we sought to elucidate the association between ALAN and prostate cancer in 27 districts within Gwangju City and urban and rural areas from South Jeolla Province in South Korea. We analyzed the correlation between ALAN and the incidence of a range of cancers by Poisson regression analysis, after adjustment for confounding risk factors, such as smoking, drinking, obesity, stress, air pollution (particulate matter <10 μm in diameter), urbanization (proportion of urbanized area), and the cancer screening rate...
2017: Chronobiology International
https://www.readbyqxmd.com/read/27923552/preleukaemic-clonal-haemopoiesis-and-risk-of-therapy-related-myeloid-neoplasms-a-case-control-study
#15
Koichi Takahashi, Feng Wang, Hagop Kantarjian, Denaha Doss, Kanhav Khanna, Erika Thompson, Li Zhao, Keyur Patel, Sattva Neelapu, Curtis Gumbs, Carlos Bueso-Ramos, Courtney D DiNardo, Simona Colla, Farhad Ravandi, Jianhua Zhang, Xuelin Huang, Xifeng Wu, Felipe Samaniego, Guillermo Garcia-Manero, P Andrew Futreal
BACKGROUND: Therapy-related myeloid neoplasms are secondary malignancies that are often fatal, but their risk factors are not well understood. Evidence suggests that individuals with clonal haemopoiesis have increased risk of developing haematological malignancies. We aimed to identify whether patients with cancer who have clonal haemopoiesis are at an increased risk of developing therapy-related myeloid neoplasms. METHODS: We did this retrospective case-control study to compare the prevalence of clonal haemopoiesis between patients treated for cancer who later developed therapy-related myeloid neoplasms (cases) and patients who did not develop these neoplasms (controls)...
January 2017: Lancet Oncology
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#16
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
November 29, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879376/the-fractionated-toona-sinensis-leaf-extract-induces-apoptosis-of-human-osteosarcoma-cells-and-inhibits-tumor-growth-in-a-murine-xenograft-model
#17
Chung-Hwan Chen, Ching-Ju Li, I-Chun Tai, Xiao-Hui Lin, Hseng-Kuang Hsu, Mei-Ling Ho
BACKGROUND: Osteosarcoma is a malignant bone tumor prevalent in adolescents with poor prognosis. Toona sinensis showed potent antiproliferation effect on lung, melatonin, ovary, colon, and liver cancers. However, the effects of the species on osteosarcoma cells are rarely investigated. RESULTS: In this study, we found fraction 1 of Toona sinensis leaf (TSL-1) resulted in inhibition of cell viability in MG-63, Saos-2, and U2OS osteosarcoma cell lines, while it only caused a moderate suppressive effect on normal osteoblasts...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#18
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27865009/melatonin-synergizes-the-chemotherapeutic-effect-of-5-fluorouracil-in-colon-cancer-by-suppressing-pi3k-akt-and-nf-%C3%AE%C2%BAb-inos-signaling-pathways
#19
Yue Gao, Xiangsheng Xiao, Changlin Zhang, Wendan Yu, Wei Guo, Zhifeng Zhang, Zhenglin Li, Xu Feng, Jiaojiao Hao, Kefang Zhang, Bingyi Xiao, Miao Chen, Wenlin Huang, Shunbin Xiong, Xiaojun Wu, Wuguo Deng
5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in colon cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts antitumor activity in various cancers, but it has never been combined with 5-FU as an anticolon cancer treatment to improve the chemotherapeutic effect of 5-FU. In this study, we assessed such combinational use in colon cancer and investigated whether melatonin could synergize the antitumor effect of 5-FU. We found that melatonin significantly enhanced the 5-FU-mediated inhibition of cell proliferation, colony formation, cell migration and invasion in colon cancer cells...
November 19, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27787516/melatonin-enhances-sensitivity-to-fluorouracil-in-oesophageal-squamous-cell-carcinoma-through-inhibition-of-erk-and-akt-pathway
#20
Yun-Xin Lu, Dong-Liang Chen, De-Shen Wang, Le-Zong Chen, Hai-Yu Mo, Hui Sheng, Long Bai, Qi-Nian Wu, Hong-En Yu, Dan Xie, Jing-Ping Yun, Zhao-Lei Zeng, Feng Wang, Huai-Qiang Ju, Rui-Hua Xu
Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted. In this study, we investigated the anti-tumour activity and underlying mechanisms of melatonin, an indoleamine compound secreted by the pineal gland as well as naturally occurring plant products, in ESCC cells and revealed that melatonin inhibited proliferation, migration, invasion and induced mitochondria-dependent apoptosis of ESCC cells in vitro and suppressed tumour growth in the subcutaneous mice model in vivo...
October 27, 2016: Cell Death & Disease
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