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Melatonin and cancer

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https://www.readbyqxmd.com/read/29156748/association-of-melatonin-membrane-receptor-1a-1b-gene-polymorphisms-with-the-occurrence-and-metastasis-of-hepatocellular-carcinoma
#1
Shih-Chi Su, Yung-Chuan Ho, Yu-Fan Liu, Russel J Reiter, Chia-Hsuan Chou, Chia-Ming Yeh, Hsiang-Lin Lee, Wen-Hung Chung, Ming-Ju Hsieh, Shun-Fa Yang
Hepatocellular carcinoma (HCC) is a prevalent primary neoplasm of the liver, whose heterogeneous global incidence suggests the likely impact of genetic variations among individuals on the susceptibility to this disease. Increasing evidence indicates that melatonin exhibits oncostatic properties in many cancer types at least in part mediated by its membrane-bound receptors, melatonin receptor 1A (encoded by MTNR1A) and 1B (MTNR1B). In this study, the effect of melatonin receptor gene polymorphisms on the risk and progression of hepatic tumors was evaluated between 335 HCC patients and 1196 cancer-free subjects...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29152648/melatonin-inhibits-colon-cancer-rko-cell-migration-by-downregulating-rho%C3%A2-associated-protein-kinase-expression-via-the-p38-mapk-signaling-pathway
#2
Zhen Liu, Duobing Zou, Xiaoping Yang, Xiaolong Xue, Li Zuo, Qing Zhou, Ruolei Hu, Yuan Wang
Melatonin is predominately produced and secreted by the pineal gland, and inhibits cell growth in various cancer cell lines such as colorectal cancer. However, the precise mechanisms involved have not been fully elucidated. In the present study, the potential molecular mechanism underlying the efficacy of melatonin on migration in RKO colon cancer cells was investigated. The effects of melatonin and H‑1152, a selective inhibitor of Rho‑associated protein kinase (ROCK), on the migration of RKO cells were analyzed by an in vitro wound healing assay...
October 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29149434/enhancement-of-therapeutic-dna-vaccine-potency-by-melatonin-through-inhibiting-vegf-expression-and-induction-of-antitumor-immunity-mediated-by-cd8-t-cells
#3
Sanaz Baghban Rahimi, Alireza Mohebbi, Gelareh Vakilzadeh, Peyvand Biglari, Soodeh Razeghi Jahromi, Seyed Reza Mohebi, Sadegh Shirian, Ali Gorji, Amir Ghaemi
To be effective, therapeutic cancer vaccines should stimulate both an effective cell-mediated and a robust cytotoxic CD8+ T-cell response against human papillomavirus (HPV)-infected cells to treat the pre-existing tumors and prevent potential future tumors. In this study, the therapeutic experiments were designed in order to evaluate antitumor effect against the syngeneic TC-1 tumor model. The anti-tumor efficacy of a HPV-16 E7 DNA vaccine adjuvanted with melatonin (MLT) was evaluated in a C57BL/6 mouse tumor model by measuring tumor growth post vaccination and the survival rate of tumor-bearing mice, analyzing the specific lymphocyte proliferation responses in control and vaccinated mice by MTT assay...
November 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29144746/oxyprenylated-phenylpropanoids-bind-to-mt1-melatonin-receptors-and-inhibit-breast-cancer-cell-proliferation-and-migration
#4
Mahmud Hasan, Salvatore Genovese, Serena Fiorito, Francesco Epifano, Paula A Witt-Enderby
Oxyprenylated compounds (i.e., ferulic acid and coumarin derivatives) demonstrate neuroprotection and anticancer properties as reported in previous studies. We have tested the affinity of oxyprenylated ferulic acid (1-4) and umbelliferone derivatives (5-11) to melatonin receptors as well as their antiproliferation and antimigratory properties against breast cancer (BC) cell lines. All the compounds except for ferulic acid, boropinic acid, and umbelliferone had binding affinities to melatonin receptors in the nM to μM range, and both auraptene and umbellinprenin reduced BC cell proliferation and migration in phenotypically diverse BC including triple negative...
November 16, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29137263/melatonin-suppresses-hepatocellular-carcinoma-progression-via-lncrna-cps1-it-mediated-hif-1%C3%AE-inactivation
#5
Tong-Hong Wang, Chi-Hao Wu, Chau-Ting Yeh, Shih-Chi Su, Shih-Min Hsia, Kung-Hao Liang, Chin-Chuan Chen, Chuen Hsueh, Chi-Yuan Chen
Melatonin is the primary pineal hormone that relays light/dark cycle information to the circadian system. It was recently reported to exert intrinsic antitumor activity in various cancers. However, the regulatory mechanisms underlying the antitumor activity of melatonin are poorly understood. Moreover, a limited number of studies have addressed the role of melatonin in hepatocellular carcinoma (HCC), a major life-threatening malignancy in both sexes in Taiwan. In this study, we investigated the antitumor effects of melatonin in HCC and explored the regulatory mechanisms underlying these effects...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134746/fenofibrate-induced-ppar-alpha-expression-was-attenuated-by-oestrogen-receptor-alpha-overexpression-in-hep3b-cells
#6
Long-Bin Jeng, Bharath Kumar Velmurugan, Hsi-Hsien Hsu, Su-Ying Wen, Chia-Yao Shen, Chih-Hao Lin, Yueh-Min Lin, Ray-Jade Chen, Wei-Wen Kuo, Chih-Yang Huang
The physiological regulation of Oestrogen receptor α (ERα) and peroxisome proliferator-activated receptor alpha (PPARα) in Hepatocellular carcinoma (HCC) remains unknown. The present study we first treat the cells with fenofibrate and further investigated the possible mechanisms of 17β-estradiol (E2 ) and/or ERα on regulating PPARα expression. We also found higher PPARα expression in the tumor area than adjacent areas and subsequently compared PPARα expression in four different hepatic cancer cell lines...
November 14, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29115538/complementary-actions-of-melatonin-on-angiogenic-factors-the-angiopoietin-tie2-axis-and-vegf-in-co%C3%A2-cultures-of-human-endothelial-and-breast-cancer-cells
#7
Alicia González-González, Alicia González, Carolina Alonso-González, Javier Menéndez-Menéndez, Carlos Martínez-Campa, Samuel Cos
Melatonin exerts oncostatic activity in breast cancer through antiangiogenic actions. There, the aim of the present study was to ascertain whether melatonin modulates, in a coordinated action, angiopoietin-1 (ANG-1), ANG-2, their cognate Tie2 receptor and VEGF in co-cultures of human endothelial cells (HUVECs) and breast cancer (MCF-7) cells. To accomplish this we used co-cultures of human breast cancer cells (MCF-7) or non-malignant human mammary epithelial cells (MCF‑10A) with endothelial cells (HUVECs)...
November 2, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29109369/effects-of-melatonin-on-glucose-homeostasis-antioxidant-ability-and-adipokine-secretion-in-icr-mice-with-na-stz-induced-hyperglycemia
#8
Chung-Cheng Lo, Shyh-Hsiang Lin, Jung-Su Chang, Yi-Wen Chien
Diabetes is often associated with decreased melatonin level. The aim was to investigate the effects of different dosage of melatonin on glucose hemostasis, antioxidant ability and adipokines secretion in diabetic institute for cancer research (ICR) mice. Forty animals were randomly divided into five groups including control (C), diabetic (D), low-dosage (L), medium-dosage (M), and high-dosage (H) groups. Groups L, M, and H, respectively, received oral melatonin at 10, 20, and 50 mg/kg of BW (body weight) daily after inducing hyperglycemia by nicotinamide (NA)/ streptozotocin (STZ)...
October 29, 2017: Nutrients
https://www.readbyqxmd.com/read/29105727/immune-pineal-axis-acute-inflammatory-responses-coordinate-melatonin-synthesis-by-pinealocytes-and-phagocytes
#9
REVIEW
Regina P Markus, Pedro A Fernandes, Gabriela S Kinker, Sanseray da Silveira Cruz-Machado, Marina Marçola
Melatonin is well known for its circadian production by the pineal gland, with a growing body of data showing its production by many other cells and organs, including immune cells. The chronobiotic role of pineal melatonin, as well as its protective effects in vitro and in vivo, have been extensively explored. However, the interaction between chronobiotic and defence functions of endogenous melatonin has been little investigated. This review details the current knowledge regarding the coordinated shift in melatonin synthesis from the pineal (circadian and monitoring roles) to the regulation of acute immune responses via immune cell production and autocrine effects, producing system interactions termed the immune-pineal axis...
November 4, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29104467/genetic-variations-of-melatonin-receptor-type-1a-are-associated-with-the-clinicopathologic-development-of-urothelial-cell-carcinoma
#10
Yung-Wei Lin, Shian-Shiang Wang, Yu-Ching Wen, Min-Che Tung, Liang-Ming Lee, Shun-Fa Yang, Ming-Hsien Chien
Melatonin counteracts tumor occurrence and tumor cell progression in several cancer types in vitro and in vivo. It acts predominantly through its melatonin receptor type 1A (MTNR1A), and genetic variations of MTNR1A affect the susceptibility several diseases and cancer. The purpose of this study was to explore the effect of MTNR1A gene polymorphisms on the susceptibility to and clinicopathological characteristics of urothelial cell carcinoma (UCC). We recruited 272 patients with UCC and 272 normal controls to analyze three common single-nucleotide polymorphisms (SNPs) (rs2119882, rs13140012, and rs6553010) of MTNR1A related to cancer risk and clinicopathological relevance according to a TaqMan-based real-time polymerase chain reaction (PCR)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29071589/melatonin-increases-human-cervical-cancer-hela-cells-apoptosis-induced-by-cisplatin-via-inhibition-of-jnk-parkin-mitophagy-axis
#11
Li Chen, Liping Liu, Yinghui Li, Jing Gao
Considering that chemotherapy resistance is vital to the progression of cervical carcinoma, emerging researchers are focused on developing anti-tumor drugs to assist the treatment efficiency of chemotherapy. Melatonin has anti-tumor activity via several mechanisms including its anti-proliferative and pro-apoptotic effects as well as its potent pro-oxidant action in tumor cells. Therefore, melatonin may be useful for the treatment of tumors in association with chemotherapy drugs. Here, we studied the effect and mechanism of melatonin on HeLa cells apoptosis under cisplatin (CIS) treatment, particularly focusing on the caspase-9-related apoptosis pathway and mitophagy-mediated anti-apoptotic mechanism...
October 25, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29066887/melatonin-potentiates-inside-out-nano-thermotherapy-in-human-breast-cancer-cells-a-potential-cancer-target-multimodality-treatment-based-on-melatonin-loaded-nanocomposite-particles
#12
Wensheng Xie, Qin Gao, Dan Wang, Wei Wang, Jie Yuan, Zhenhu Guo, Hao Yan, Xiumei Wang, Xiaodan Sun, Lingyun Zhao
PURPOSE: With the wide recognition of oncostatic effect of melatonin, the current study proposes a potential breast cancer target multimodality treatment based on melatonin-loaded magnetic nanocomposite particles (Melatonin-MNPs). METHODS: Melatonin-MNPs were fabricated by the single emulsion solvent extraction/evaporation method. RESULTS: Based on the facilitated transport of melatonin by the GLUT overexpressed on the cell membrane, such Melatonin-MNPs can be more favorably uptaken by MCF-7 cells compared with the melatonin-free nanocomposite particles, which indicates the cancer targeting ability of melatonin molecule...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29057661/the-effect-of-zinc-and-melatonin-supplementation-on-immunity-parameters-in-breast-cancer-induced-by-dmba-in-rats
#13
Saltuk Bugra Baltaci, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Ayca Emsen, Hasibe Artac
OBJECTIVE: The aim of the study was to determine the effects of zinc and melatonin supplements on the immunity parameters of female rats with breast cancer induced by DMBA. METHODS: Group 1; Control, Group 2; 7,12-dimethylbenz[a]anthracene (DMBA), Group 3; DMBA + zinc, Group 4; DMBA + melatonin, Group 5; DMBA + zinc + melatonin. The rats' breast cancer was induced by DMBA 80 mg/kg. Groups 3-5 received daily 5 mg/kg doses of zinc, melatonin, and zinc + melatonin, respectively...
October 23, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29053271/discovery-of-7-18-f-fluorotryptophan-as-a-novel-positron-emission-tomography-pet-probe-for-the-visualization-of-tryptophan-metabolism-in-vivo
#14
Boris D Zlatopolskiy, Johannes Zischler, Dominique Schäfer, Elizaveta A Urusova, Mehrab Guliyev, Olesia Bannykh, Heike Endepols, Bernd Neumaier
Tryptophan and its metabolites are involved in different physiological and pathophysiological processes. Consequently, positron emission tomography (PET) tracers addressing tryptophan metabolic pathways should allow the detection of different pathologies like neurological disorders and cancer. Herein we report an efficient method for the preparation of fluorotryptophans labeled in different positions with (18)F and their biological evaluation. 4-7-[(18)F]Fluorotryptophans ([(18)F]FTrps) were prepared according to a modified protocol of alcohol-enhanced Cu-mediated radiofluorination in 30-53% radiochemical yields...
November 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28982855/impressive-suppression-of-colon-cancer-growth-by-triple-combination-sn38-ef24-melatonin-oncogenic-versus-onco-suppressive-reactive-oxygen-species
#15
Rumiana Bakalova, Zhivko Zhelev, Sayaka Shibata, Biliana Nikolova, Ichio Aoki, Tatsuya Higashi
BACKGROUND/AIM: The study aimed to investigate the effect of multi-targeted combinations (SN38/EF24; SN38/EF24/melatonin) on the growth of colon cancer in experimental animals and their impact on the ratio "oncogenic"/"onco-suppressive" reactive oxygen species (ROS) - a crucial factor for triggering carcinogenesis, as well as for development of effective therapeutic strategies. MATERIALS AND METHODS: The experiments were conducted on colon cancer-grafted mice - non-treated, SN38/EF24-treated and SN38/EF24/melatonin-treated within 22 days...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28978121/antiproliferative-and-pro-apoptotic-activity-of-melatonin-analogues-on-melanoma-and-breast-cancer-cells
#16
Giuliana Gatti, Valeria Lucini, Silvana Dugnani, Angela Calastretti, Gilberto Spadoni, Annalida Bedini, Silvia Rivara, Marco Mor, Gianfranco Canti, Francesco Scaglione, Annamaria Bevilacqua
Melatonin plays different physiological functions ranging from the regulation of circadian rhythms to tumor inhibition, owing to its antioxidant, immunomodulatory and anti-aging properties. Due to its pleiotropic functions, melatonin has been shown to elicit cytoprotective processes in normal cells and trigger pro-apoptotic signals in cancer cells. The therapeutic potential of melatonin analogues prompted us to investigate the in vitro and in vivo antitumor activity of new melatonin derivatives and explore the underlying molecular mechanisms...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28974455/melatonin-as-an-angiogenesis-inhibitor-to-combat-cancer-mechanistic-evidence
#17
REVIEW
Nasser Hashemi Goradel, Mohammad Hossein Asghari, Milad Moloudizargari, Babak Negahdari, Hamed Haghi-Aminjan, Mohammad Abdollahi
Melatonin, a pineal indolamine, participates in different body functions and is shown to possess diverse biological activities such as anti-tumor action. Angiogenesis inhibition is one of the mechanisms by which melatonin exerts its oncostatic effects. Increased angiogenesis is a major feature of tumor progression, thus angiogenesis inhibition is a critical step in cancer therapy. Melatonin employs a variety of mechanisms to target nutrients and oxygen supply to cancer cells. At the transcriptional level, hypoxia induced factor-1α (HIF-1α) and the genes under its control, such as vascular endothelial growth factor (VEGF) are the main targets of melatonin for inhibition of angiogenesis...
November 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28956121/participation-of-mt3-melatonin-receptors-in-the-synergistic-effect-of-melatonin-on-cytotoxic-and-apoptotic-actions-evoked-by-chemotherapeutics
#18
Roberto Pariente, Ignacio Bejarano, Javier Espino, Ana B Rodríguez, José A Pariente
BACKGROUND: Melatonin has antitumor activity via several mechanisms including its antiproliferative and proapoptotic effects in addition to its potent antioxidant actions. Therefore, melatonin may be useful in the treatment of tumors in association with chemotherapy drugs. PURPOSE AND METHODS: This study was performed to study the role of melatonin receptors on the cytotoxicity and apoptosis induced by the chemotherapeutic agents cisplatin and 5-fluorouracil in two tumor cell lines, such as human colorectal cancer HT-29 cells and cervical cancer HeLa cells...
September 27, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28933733/melatonin-decreases-glucose-metabolism-in-prostate-cancer-cells-a-13-c-stable-isotope-resolved-metabolomic-study
#19
David Hevia, Pedro Gonzalez-Menendez, Mario Fernandez-Fernandez, Sergio Cueto, Pablo Rodriguez-Gonzalez, Jose I Garcia-Alonso, Juan C Mayo, Rosa M Sainz
The pineal neuroindole melatonin exerts an exceptional variety of systemic functions. Some of them are exerted through its specific membrane receptors type 1 and type 2 (MT1 and MT2) while others are mediated by receptor-independent mechanisms. A potential transport of melatonin through facilitative glucose transporters (GLUT/SLC2A) was proposed in prostate cancer cells. The prostate cells have a particular metabolism that changes during tumor progression. During the first steps of carcinogenesis, oxidative phosphorylation is reactivated while the switch to the "Warburg effect" only occurs in advanced tumors and in the metastatic stage...
July 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28933565/sleep-duration-nightshift-work-and-the-timing-of-meals-and-urinary-levels-of-8-isoprostane-and-6-sulfatoxymelatonin-in-japanese-women
#20
Chisato Nagata, Takashi Tamura, Keiko Wada, Kie Konishi, Yuko Goto, Yasuko Nagao, Kazuhiro Ishihara, Satoru Yamamoto
It has been hypothesized that disruption of circadian rhythms affects human health. Shift work and sleep deprivation are thought to disrupt the normal light-dark cycle, although the disruption due to shiftwork may be dependent on sleep deprivation. Both conditions have been suggested to be associated with an increased risk of cardiometabolic disorders. Non-photic environmental factors, such as the timing of eating, are also thought to regulate circadian rhythm and thus, may have effects on health, but the evidence from human studies is scarce...
September 21, 2017: Chronobiology International
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