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Melatonin and cancer

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https://www.readbyqxmd.com/read/28063410/the-impact-of-different-extracellular-matrices-on-melatonin-effect-in-proliferation-and-stemness-properties-of-ovarian-cancer-cells
#1
Maryam Akbarzadeh, Reza Rahbarghazi, Elahe Nabat, Ali Akbar Movassaghpour, Daruish Shanehbandi, Behnaz Faramarzian Azimi Maragheh, Danial Matluobi, Balal Barazvan, Masoume Kazemi, Nasser Samadi, Mohammad Nouri
AIM: Endogenous melatonin has numerous physiological roles on modulating the function of different organs. Recent studies revealed oncostatic and protective effects of this molecule on tumor development. In this study, we examined the impact of melatonin and key underlying mechanisms on stemness, morphology, invasiveness and viability of SKOV3 ovarian cancer cells in different types of extracellular matrix. METHODS: Cell viability was evaluated by MTT Assay. Colony-forming assay was performed by seeding 4×10(3) cells on different matrices in six well-plate...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28027652/melatonin-ameliorates-busulfan-induced-spermatogonial-stem-cell-oxidative-apoptosis-in-mouse-testes
#2
Bo Li, Xin He, Mengru Zhuang, Bowen Niu, Chongyang Wu, Hailong Mu, Furong Tang, Yanhua Cui, Weishuai Liu, Baoyu Zhao, Sha Peng, Guangpeng Li, Jinlian Hua
AIMS: Many men endure immunosuppressive or anticancer treatments that contain alkylating agents prior to the age of sexual maturity, especially the increasing number of preadolescent males who undergo busulfan treatment for myeloablative conditioning prior to hematopoietic stem cell transplantation. Prior to sperm production, there are no sperm available for cryopreservation. Thus, it is necessary to identify a solution to ameliorate the busulfan-induced damage of spermatogonial stem cells (SSCs)...
December 27, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28027439/carbamate-insecticides-target-human-melatonin-receptors
#3
Marina Popovska-Gorevski, Margarita L Dubocovich, Rajendram V Rajnarayanan
Carbaryl (1-naphthyl methylcarbamate) and carbofuran (2,3-dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate) are among the most toxic insecticides, implicated in a variety of diseases including diabetes and cancer among others. Using an integrated pharmacoinformatics based screening approach, we have identified these insecticides to be structural mimics of the neurohormone melatonin and were able to bind to the putative melatonin binding sites in MT1 and MT2 melatonin receptors in silico. Carbaryl and carbofuran then were tested for competition with 2-[125I]-iodomelatonin (300 pM) binding to hMT1 or hMT2 receptors stably expressed in CHO cells...
December 27, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27997348/relationship-between-plasma-and-salivary-melatonin-and-cortisol-investigated-by-lc-ms-ms
#4
Martijn van Faassen, Rainer Bischoff, Ido P Kema
BACKGROUND: Disturbance of the circadian rhythm has been associated with disease states, such as metabolic disorders, depression and cancer. Quantification of the circadian markers such as melatonin and cortisol critically depend on reliable and reproducible analytical methods. Previously, melatonin and cortisol were primarily analyzed separately, mainly using immunoassays. METHODS: Here we describe the validation and application of a high-throughput liquid chromatography in combination with mass spectrometry (LC-MS/MS) method for the combined analysis of melatonin and cortisol in plasma and saliva...
December 20, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27996309/the-association-between-artificial-light-at-night-and-prostate-cancer-in-gwangju-city-and-south-jeolla-province-of-south-korea
#5
Ka Young Kim, Eunil Lee, Yun Jeong Kim, Jinsun Kim
ABSRACT Exposure to artificial light at night (ALAN) has been reported to be associated with various pathological changes including sleep deprivation, circadian rhythm disruption, and melatonin suppression with increase in various cancers such as breast or prostate cancers. In this study, we sought to elucidate the association between ALAN and prostate cancer in 27 districts within Gwangju City and urban and rural areas from South Jeolla Province in South Korea. We analyzed the correlation between ALAN and the incidence of a range of cancers by Poisson regression analysis, after adjustment for confounding risk factors, such as smoking, drinking, obesity, stress, air pollution (particulate matter <10 μm in diameter), urbanization (proportion of urbanized area), and the cancer screening rate...
December 20, 2016: Chronobiology International
https://www.readbyqxmd.com/read/27923552/preleukaemic-clonal-haemopoiesis-and-risk-of-therapy-related-myeloid-neoplasms-a-case-control-study
#6
Koichi Takahashi, Feng Wang, Hagop Kantarjian, Denaha Doss, Kanhav Khanna, Erika Thompson, Li Zhao, Keyur Patel, Sattva Neelapu, Curtis Gumbs, Carlos Bueso-Ramos, Courtney D DiNardo, Simona Colla, Farhad Ravandi, Jianhua Zhang, Xuelin Huang, Xifeng Wu, Felipe Samaniego, Guillermo Garcia-Manero, P Andrew Futreal
BACKGROUND: Therapy-related myeloid neoplasms are secondary malignancies that are often fatal, but their risk factors are not well understood. Evidence suggests that individuals with clonal haemopoiesis have increased risk of developing haematological malignancies. We aimed to identify whether patients with cancer who have clonal haemopoiesis are at an increased risk of developing therapy-related myeloid neoplasms. METHODS: We did this retrospective case-control study to compare the prevalence of clonal haemopoiesis between patients treated for cancer who later developed therapy-related myeloid neoplasms (cases) and patients who did not develop these neoplasms (controls)...
December 2, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27899698/illuminating-a-risk-for-breast-cancer-a-preliminary-ecological-study-on-the-association-between-streetlight-and-breast-cancer
#7
Atalya Keshet-Sitton, Keren Or-Chen, Eran Huber, Abraham Haim
Artificial light at night (ALAN) for elongating photophase is a new source of pollution. We examined the association between measured ALAN levels and breast cancer (BC) standard morbidity ratio (SMR) at a statistical area (SA) level in an urban environment. Sample size consisted of 266 new BC cases ages 35-74. Light measurements (lux) were performed in 11 SAs. A new calculated variable of morbidity per SA size (SMR35-74/km(2)) was correlated with the light variables per road length, using Pearson correlations (P < ...
November 29, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27879376/the-fractionated-toona-sinensis-leaf-extract-induces-apoptosis-of-human-osteosarcoma-cells-and-inhibits-tumor-growth-in-a-murine-xenograft-model
#8
Chung-Hwan Chen, Ching-Ju Li, I-Chun Tai, Xiao-Hui Lin, Hseng-Kuang Hsu, Mei-Ling Ho
BACKGROUND: Osteosarcoma is a malignant bone tumor prevalent in adolescents with poor prognosis. Toona sinensis showed potent antiproliferation effect on lung, melatonin, ovary, colon, and liver cancers. However, the effects of the species on osteosarcoma cells are rarely investigated. RESULTS: In this study, we found fraction 1 of Toona sinensis leaf (TSL-1) resulted in inhibition of cell viability in MG-63, Saos-2, and U2OS osteosarcoma cell lines, while it only caused a moderate suppressive effect on normal osteoblasts...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27876126/regular-sun-exposure-benefits-health
#9
H J van der Rhee, E de Vries, J W Coebergh
Since it was discovered that UV radiation was the main environmental cause of skin cancer, primary prevention programs have been started. These programs advise to avoid exposure to sunlight. However, the question arises whether sun-shunning behaviour might have an effect on general health. During the last decades new favourable associations between sunlight and disease have been discovered. There is growing observational and experimental evidence that regular exposure to sunlight contributes to the prevention of colon-, breast-, prostate cancer, non-Hodgkin lymphoma, multiple sclerosis, hypertension and diabetes...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27865009/melatonin-synergizes-the-chemotherapeutic-effect-of-5-fluorouracil-in-colon-cancer-by-suppressing-pi3k-akt-and-nf-%C3%AE%C2%BAb-inos-signaling-pathways
#10
Yue Gao, Xiangsheng Xiao, Changlin Zhang, Wendan Yu, Wei Guo, Zhifeng Zhang, Zhenglin Li, Xu Feng, Jiaojiao Hao, Kefang Zhang, Bingyi Xiao, Miao Chen, Wenlin Huang, Shunbin Xiong, Xiaojun Wu, Wuguo Deng
5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in colon cancer treatment, but has a narrow therapeutic index limited by its toxicity. Melatonin exerts antitumor activity in various cancers, but it has never been combined with 5-FU as an anticolon cancer treatment to improve the chemotherapeutic effect of 5-FU. In this study, we assessed such combinational use in colon cancer and investigated whether melatonin could synergize the antitumor effect of 5-FU. We found that melatonin significantly enhanced the 5-FU-mediated inhibition of cell proliferation, colony formation, cell migration and invasion in colon cancer cells...
November 19, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27787516/melatonin-enhances-sensitivity-to-fluorouracil-in-oesophageal-squamous-cell-carcinoma-through-inhibition-of-erk-and-akt-pathway
#11
Yun-Xin Lu, Dong-Liang Chen, De-Shen Wang, Le-Zong Chen, Hai-Yu Mo, Hui Sheng, Long Bai, Qi-Nian Wu, Hong-En Yu, Dan Xie, Jing-Ping Yun, Zhao-Lei Zeng, Feng Wang, Huai-Qiang Ju, Rui-Hua Xu
Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted. In this study, we investigated the anti-tumour activity and underlying mechanisms of melatonin, an indoleamine compound secreted by the pineal gland as well as naturally occurring plant products, in ESCC cells and revealed that melatonin inhibited proliferation, migration, invasion and induced mitochondria-dependent apoptosis of ESCC cells in vitro and suppressed tumour growth in the subcutaneous mice model in vivo...
October 27, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27763686/melatonin-and-the-pathologies-of-weakened-or-dysregulated-circadian-oscillators
#12
REVIEW
Rüdiger Hardeland
Dynamic aspects of melatonin's actions merit increasing future attention. This concerns particularly entirely different effects in senescent, weakened oscillators and in dysregulated oscillators of cancer cells that may be epigenetically blocked. This is especially obvious in the case of sirtuin 1, which is upregulated by melatonin in aged tissues, but strongly downregulated in several cancer cells. These findings are not at all controversial, but are explained on the basis of divergent changes in weakened and dysregulated oscillators...
January 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/27736013/igfbp3-and-mapk-erk-signaling-mediates-melatonin-induced-antitumor-activity-in-prostate-cancer
#13
Juan C Mayo, David Hevia, Isabel Quiros-Gonzalez, Aida Rodriguez-Garcia, Pedro Gonzalez-Menendez, Vanesa Cepas, Iván Gonzalez-Pola, Rosa M Sainz
Treatment of prostate cancer (PCa), a leading cause of cancer among males, lacks successful strategies especially in advanced, hormone-refractory stages. Some clinical studies have shown an increase in neuroendocrine-like cells parallel to the tumor progression but their exact role is a matter of debate. The prostate is a well-known target for melatonin, which reduces PCa cells proliferation and induces neuroendocrine differentiation. To evaluate the mechanisms underlying the indole effects on neuroendocrine differentiation and its impact on PCa progression, we used a cell culture model (LNCaP) and a murine model (TRAMP)...
January 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/27706852/cancer-metastasis-mechanisms-of-inhibition-by-melatonin
#14
REVIEW
Shih-Chi Su, Ming-Ju Hsieh, Wei-En Yang, Wen-Hung Chung, Russel J Reiter, Shun-Fa Yang
Melatonin is a naturally occurring molecule secreted by the pineal gland and known as a gatekeeper of circadian clocks. Mounting evidence indicates that melatonin, employing multiple and interrelated mechanisms, exhibits a variety of oncostatic properties in a myriad of tumors during different stages of their progression. Tumor metastasis, which commonly occurs at the late stage, is responsible for the majority of cancer deaths; metastases lead to the development of secondary tumors distant from a primary site...
January 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/27696512/melatonin-prevents-deregulation-of-the-sphingosine-kinase-sphingosine-1-phosphate-signaling-pathway-in-a-mouse-model-of-diethylnitrosamine-induced-hepatocellular-carcinoma
#15
Diana I Sánchez, Bárbara González-Fernández, Beatriz San-Miguel, Juan Ortiz de Urbina, Irene Crespo, Javier González-Gallego, María J Tuñón
The sphingosine kinase (SphK)/sphingosine 1-phosphate (S1P) pathway is involved in multiple biological processes, including carcinogenesis. Melatonin shows beneficial effects in cell and animal models of hepatocellular carcinoma, but it is unknown if they are associated with the modulation of the SphK/S1P system, along with different downstream signaling pathways modified in cancer. We investigated the effects of melatonin in mice which received diethylnitrosamine (DEN) (35 mg/kg body weight i.p) once a week for 8 weeks...
January 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/27671309/evaluation-of-melatonin-effect-on-human-breast-cancer-stem-cells-using-a-three-dimensional-growth-method-of-mammospheres
#16
Juliana Ramos Lopes, Mayume da Silva Kavagutti, Felipe Arthur Faustino Medeiros, Debora Aparecida Pires De Campos Zuccari
BACKGROUND: The high rates of women&#039;s death from breast cancer occur due to acquired resistance by patients to certain treatments, enabling the recurrence and/or tumor growth, invasion and metastasis. It has been demonstrated the presence of cancer stem cells in human tumors, as responsible for recurrence and resistance to therapy. Studies have identified OCT4 as responsible for self-renewal and maintenance of pluripotency of stem cells. Thus, it is interesting to study potential drugs that target this specific population in breast cancer...
September 22, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27666165/melatonin-induces-cell-apoptosis-in-mia-paca-2-cells-via-the-suppression-of-nuclear-factor-%C3%AE%C2%BAb-and-activation-of-erk-and-jnk-a-novel-therapeutic-implication-for-pancreatic-cancer
#17
Weimin Li, Jiansheng Wu, Zhiyin Li, Zhibo Zhou, Chao Zheng, Le Lin, Binbin Tan, Min Huang, Mengdi Fan
Melatonin is synthesized by the pineal gland and is released into the blood. In the last several years, some studies have shown that melatonin has anticancer properties; however, the mechanisms behind the antitumour traits are unclear, especially in pancreatic cancer. Therefore, in the present study, we investigated the antitumour effects of melatonin on the human pancreatic carcinoma cell line MIA PaCa‑2 and explored its biological mechanisms. MIA PaCa‑2 cells were treated with melatonin, and we used a CCK‑8 assay to evaluate the cell viability...
November 2016: Oncology Reports
https://www.readbyqxmd.com/read/27660402/women-in-cancer-thematic-review-circadian-rhythmicity-and-the-influence-of-clock-genes-on-prostate-cancer
#18
REVIEW
Zsofia Kiss, Paramita M Ghosh
The androgen receptor (AR) plays a key role in the development and progression of prostate cancer (CaP). Since the mid-1990s, reports in the literature pointed out higher incidences of CaP in some select groups, such as airline pilots and night shift workers in comparison with those working regular hours. The common finding in these 'high-risk' groups was that they all experienced a deregulation of the body's internal circadian rhythm. Here, we discuss how the circadian rhythm affects androgen levels and modulates CaP development and progression...
November 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/27604906/quantitative-proteomic-profiling-reveals-that-diverse-metabolic-pathways-are-influenced-by-melatonin-in-an-in-vivo-model-of-ovarian-carcinoma
#19
Luiz Gustavo A Chuffa, Luiz Antonio Lupi Júnior, Fábio R F Seiva, Marcelo Martinez, Raquel F Domeniconi, Patricia Fernanda F Pinheiro, Lucilene D Dos Santos, Francisco Eduardo Martinez
To obtain more information into the molecular mechanisms underlying ovarian cancer (OC), we proposed a comparative proteomic analysis in animals receiving long-term melatonin as therapy or only vehicle using multidimensional protein identification combined with mass spectrometry. To induce tumor, a single dose of 100 μg 7,12-dimethylbenz(a)anthracene (DMBA) dissolved in 10 μL of sesame oil was injected under the left ovarian bursa of 20 Fischer 344 rats. The right ovaries were injected with sesame oil only...
October 7, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27585541/circadian-rhythm-and-menopause
#20
A Pines
Circadian rhythm is an internal biological clock which initiates and monitors various physiological processes with a fixed time-related schedule. The master circadian pacemaker is located in the suprachiasmatic nucleus in the hypothalamus. The circadian clock undergoes significant changes throughout the life span, at both the physiological and molecular levels. This cyclical physiological process, which is very complex and multifactorial, may be associated with metabolic alterations, atherosclerosis, impaired cognition, mood disturbances and even development of cancer...
September 2, 2016: Climacteric: the Journal of the International Menopause Society
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