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JOURNAL ARTICLE
Angharad N de Cates, Gennaro Catone, Steven Marwaha, Paul Bebbington, Clara S Humpston, Matthew R Broome
BACKGROUND: Schizophrenia is associated with premature mortality, partly through increased suicide rates. AIMS: To examine (1) if persecutory ideas, auditory hallucinations, and probable cases of psychosis are associated with suicidal thoughts or attempts cross-sectionally and prospectively, and (2) if such links are mediated by specific affective factors (depression, impulsivity, mood instability). METHOD: We analysed the 2000, 2007, and 2014 British Adult Psychiatric Morbidity Surveys (APMS) separately...
July 7, 2021: Schizophrenia Research
#22
Yao Hu, Adrienne M Stilp, Caitlin P McHugh, Shuquan Rao, Deepti Jain, Xiuwen Zheng, John Lane, Sébastian Méric de Bellefon, Laura M Raffield, Ming-Huei Chen, Lisa R Yanek, Marsha Wheeler, Yao Yao, Chunyan Ren, Jai Broome, Jee-Young Moon, Paul S de Vries, Brian D Hobbs, Quan Sun, Praveen Surendran, Jennifer A Brody, Thomas W Blackwell, Hélène Choquet, Kathleen Ryan, Ravindranath Duggirala, Nancy Heard-Costa, Zhe Wang, Nathalie Chami, Michael H Preuss, Nancy Min, Lynette Ekunwe, Leslie A Lange, Mary Cushman, Nauder Faraday, Joanne E Curran, Laura Almasy, Kousik Kundu, Albert V Smith, Stacey Gabriel, Jerome I Rotter, Myriam Fornage, Donald M Lloyd-Jones, Ramachandran S Vasan, Nicholas L Smith, Kari E North, Eric Boerwinkle, Lewis C Becker, Joshua P Lewis, Goncalo R Abecasis, Lifang Hou, Jeffrey R O'Connell, Alanna C Morrison, Terri H Beaty, Robert Kaplan, Adolfo Correa, John Blangero, Eric Jorgenson, Bruce M Psaty, Charles Kooperberg, Russell T Walton, Benjamin P Kleinstiver, Hua Tang, Ruth J F Loos, Nicole Soranzo, Adam S Butterworth, Debbie Nickerson, Stephen S Rich, Braxton D Mitchell, Andrew D Johnson, Paul L Auer, Yun Li, Rasika A Mathias, Guillaume Lettre, Nathan Pankratz, Cathy C Laurie, Cecelia A Laurie, Daniel E Bauer, Matthew P Conomos, Alexander P Reiner
No abstract text is available yet for this article.
June 3, 2021: American Journal of Human Genetics
#23
JOURNAL ARTICLE
Yao Hu, Adrienne M Stilp, Caitlin P McHugh, Shuquan Rao, Deepti Jain, Xiuwen Zheng, John Lane, Sébastian Méric de Bellefon, Laura M Raffield, Ming-Huei Chen, Lisa R Yanek, Marsha Wheeler, Yao Yao, Chunyan Ren, Jai Broome, Jee-Young Moon, Paul S de Vries, Brian D Hobbs, Quan Sun, Praveen Surendran, Jennifer A Brody, Thomas W Blackwell, Hélène Choquet, Kathleen Ryan, Ravindranath Duggirala, Nancy Heard-Costa, Zhe Wang, Nathalie Chami, Michael H Preuss, Nancy Min, Lynette Ekunwe, Leslie A Lange, Mary Cushman, Nauder Faraday, Joanne E Curran, Laura Almasy, Kousik Kundu, Albert V Smith, Stacey Gabriel, Jerome I Rotter, Myriam Fornage, Donald M Lloyd-Jones, Ramachandran S Vasan, Nicholas L Smith, Kari E North, Eric Boerwinkle, Lewis C Becker, Joshua P Lewis, Goncalo R Abecasis, Lifang Hou, Jeffrey R O'Connell, Alanna C Morrison, Terri H Beaty, Robert Kaplan, Adolfo Correa, John Blangero, Eric Jorgenson, Bruce M Psaty, Charles Kooperberg, Russell T Walton, Benjamin P Kleinstiver, Hua Tang, Ruth J F Loos, Nicole Soranzo, Adam S Butterworth, Debbie Nickerson, Stephen S Rich, Braxton D Mitchell, Andrew D Johnson, Paul L Auer, Yun Li, Rasika A Mathias, Guillaume Lettre, Nathan Pankratz, Cathy C Laurie, Cecelia A Laurie, Daniel E Bauer, Matthew P Conomos, Alexander P Reiner
Whole-genome sequencing (WGS), a powerful tool for detecting novel coding and non-coding disease-causing variants, has largely been applied to clinical diagnosis of inherited disorders. Here we leveraged WGS data in up to 62,653 ethnically diverse participants from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program and assessed statistical association of variants with seven red blood cell (RBC) quantitative traits. We discovered 14 single variant-RBC trait associations at 12 genomic loci, which have not been reported previously...
May 6, 2021: American Journal of Human Genetics
#24
JOURNAL ARTICLE
Isabel Morales-Muñoz, Rachel Upthegrove, Pavan K Mallikarjun, Matthew R Broome, Steven Marwaha
Importance: Cognitive deficits are core features of mental disorders and are important in predicting long-term prognosis. However, it is still unknown whether individual patterns of cognitive deficits predate specific mental disorders. Objective: To investigate the specificity of the associations of attention, working memory, and inhibition in childhood with borderline personality disorder (BPD), psychosis, depression, and hypomania in adolescence and young adulthood...
April 1, 2021: JAMA Network Open
#25
Alexander G Bick, Joshua S Weinstock, Satish K Nandakumar, Charles P Fulco, Erik L Bao, Seyedeh M Zekavat, Mindy D Szeto, Xiaotian Liao, Matthew J Leventhal, Joseph Nasser, Kyle Chang, Cecelia Laurie, Bala Bharathi Burugula, Christopher J Gibson, Abhishek Niroula, Amy E Lin, Margaret A Taub, Francois Aguet, Kristin Ardlie, Braxton D Mitchell, Kathleen C Barnes, Arden Moscati, Myriam Fornage, Susan Redline, Bruce M Psaty, Edwin K Silverman, Scott T Weiss, Nicholette D Palmer, Ramachandran S Vasan, Esteban G Burchard, Sharon L R Kardia, Jiang He, Robert C Kaplan, Nicholas L Smith, Donna K Arnett, David A Schwartz, Adolfo Correa, Mariza de Andrade, Xiuqing Guo, Barbara A Konkle, Brian Custer, Juan M Peralta, Hongsheng Gui, Deborah A Meyers, Stephen T McGarvey, Ida Yii-Der Chen, M Benjamin Shoemaker, Patricia A Peyser, Jai G Broome, Stephanie M Gogarten, Fei Fei Wang, Quenna Wong, May E Montasser, Michelle Daya, Eimear E Kenny, Kari E North, Lenore J Launer, Brian E Cade, Joshua C Bis, Michael H Cho, Jessica Lasky-Su, Donald W Bowden, L Adrienne Cupples, Angel C Y Mak, Lewis C Becker, Jennifer A Smith, Tanika N Kelly, Stella Aslibekyan, Susan R Heckbert, Hemant K Tiwari, Ivana V Yang, John A Heit, Steven A Lubitz, Jill M Johnsen, Joanne E Curran, Sally E Wenzel, Daniel E Weeks, Dabeeru C Rao, Dawood Darbar, Jee-Young Moon, Russell P Tracy, Erin J Buth, Nicholas Rafaels, Ruth J F Loos, Peter Durda, Yongmei Liu, Lifang Hou, Jiwon Lee, Priyadarshini Kachroo, Barry I Freedman, Daniel Levy, Lawrence F Bielak, James E Hixson, James S Floyd, Eric A Whitsel, Patrick T Ellinor, Marguerite R Irvin, Tasha E Fingerlin, Laura M Raffield, Sebastian M Armasu, Marsha M Wheeler, Ester C Sabino, John Blangero, L Keoki Williams, Bruce D Levy, Wayne Huey-Herng Sheu, Dan M Roden, Eric Boerwinkle, JoAnn E Manson, Rasika A Mathias, Pinkal Desai, Kent D Taylor, Andrew D Johnson, Paul L Auer, Charles Kooperberg, Cathy C Laurie, Thomas W Blackwell, Albert V Smith, Hongyu Zhao, Ethan Lange, Leslie Lange, Stephen S Rich, Jerome I Rotter, James G Wilson, Paul Scheet, Jacob O Kitzman, Eric S Lander, Jesse M Engreitz, Benjamin L Ebert, Alexander P Reiner, Siddhartha Jaiswal, Gonçalo Abecasis, Vijay G Sankaran, Sekar Kathiresan, Pradeep Natarajan
No abstract text is available yet for this article.
March 11, 2021: Nature
#26
JOURNAL ARTICLE
Rosa Ritunnano, Clara Humpston, Matthew R Broome
Can delusions, in the context of psychosis, enhance a person's sense of meaningfulness? The case described here suggests that, in some circumstances, they can. This prompts further questions into the complexities of delusion as a lived phenomenon, with important implications for the clinical encounter. While assumptions of meaninglessness are often associated with concepts of 'disorder', 'harm' and 'dysfunction', we suggest that meaning can nonetheless be found within what is commonly taken to be incomprehensible or even meaningless...
January 12, 2021: BJPsych Bulletin
#27
JOURNAL ARTICLE
Rachel Upthegrove, Angharad de Cates, Alice Shuttleworth, Derek K Tracy, Matthew R Broome, Anne Lingford-Hughes
Women in academic publishing and academic psychiatry face many challenges of gender inequality, including significant pay differentials, poor visibility in senior positions and a male-dominated hierarchical system. We discuss this problem and outline how the BJPsych plans to tackle these issues it in its own publishing.
November 25, 2020: British Journal of Psychiatry
#28
JOURNAL ARTICLE
Kareen Heinze, Jennifer Cumming, Amrita Dosanjh, Sophia Palin, Shannen Poulton, Andrew P Bagshaw, Matthew R Broome
OBJECTIVE: To investigate putative neurobiological mechanisms that link longer-term physical activity interventions to mental health and cognitive outcomes using randomised controlled trials in children, adolescents and young adults. DATA SOURCES: A range of medical and psychological science electronic databases were searched (MEDLINE, EMBASE, Scopus, Web of Science, PsychINFO). REVIEW METHODS: Original research studies were selected, data were extracted and quality was appraised...
January 2021: Neuroscience and Biobehavioral Reviews
#29
JOURNAL ARTICLE
Alexander G Bick, Joshua S Weinstock, Satish K Nandakumar, Charles P Fulco, Erik L Bao, Seyedeh M Zekavat, Mindy D Szeto, Xiaotian Liao, Matthew J Leventhal, Joseph Nasser, Kyle Chang, Cecelia Laurie, Bala Bharathi Burugula, Christopher J Gibson, Amy E Lin, Margaret A Taub, Francois Aguet, Kristin Ardlie, Braxton D Mitchell, Kathleen C Barnes, Arden Moscati, Myriam Fornage, Susan Redline, Bruce M Psaty, Edwin K Silverman, Scott T Weiss, Nicholette D Palmer, Ramachandran S Vasan, Esteban G Burchard, Sharon L R Kardia, Jiang He, Robert C Kaplan, Nicholas L Smith, Donna K Arnett, David A Schwartz, Adolfo Correa, Mariza de Andrade, Xiuqing Guo, Barbara A Konkle, Brian Custer, Juan M Peralta, Hongsheng Gui, Deborah A Meyers, Stephen T McGarvey, Ida Yii-Der Chen, M Benjamin Shoemaker, Patricia A Peyser, Jai G Broome, Stephanie M Gogarten, Fei Fei Wang, Quenna Wong, May E Montasser, Michelle Daya, Eimear E Kenny, Kari E North, Lenore J Launer, Brian E Cade, Joshua C Bis, Michael H Cho, Jessica Lasky-Su, Donald W Bowden, L Adrienne Cupples, Angel C Y Mak, Lewis C Becker, Jennifer A Smith, Tanika N Kelly, Stella Aslibekyan, Susan R Heckbert, Hemant K Tiwari, Ivana V Yang, John A Heit, Steven A Lubitz, Jill M Johnsen, Joanne E Curran, Sally E Wenzel, Daniel E Weeks, Dabeeru C Rao, Dawood Darbar, Jee-Young Moon, Russell P Tracy, Erin J Buth, Nicholas Rafaels, Ruth J F Loos, Peter Durda, Yongmei Liu, Lifang Hou, Jiwon Lee, Priyadarshini Kachroo, Barry I Freedman, Daniel Levy, Lawrence F Bielak, James E Hixson, James S Floyd, Eric A Whitsel, Patrick T Ellinor, Marguerite R Irvin, Tasha E Fingerlin, Laura M Raffield, Sebastian M Armasu, Marsha M Wheeler, Ester C Sabino, John Blangero, L Keoki Williams, Bruce D Levy, Wayne Huey-Herng Sheu, Dan M Roden, Eric Boerwinkle, JoAnn E Manson, Rasika A Mathias, Pinkal Desai, Kent D Taylor, Andrew D Johnson, Paul L Auer, Charles Kooperberg, Cathy C Laurie, Thomas W Blackwell, Albert V Smith, Hongyu Zhao, Ethan Lange, Leslie Lange, Stephen S Rich, Jerome I Rotter, James G Wilson, Paul Scheet, Jacob O Kitzman, Eric S Lander, Jesse M Engreitz, Benjamin L Ebert, Alexander P Reiner, Siddhartha Jaiswal, Gonçalo Abecasis, Vijay G Sankaran, Sekar Kathiresan, Pradeep Natarajan
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1 . The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoietic stem cell populations has recently been associated with both haematological cancer2-4 and coronary heart disease5 -this phenomenon is termed clonal haematopoiesis of indeterminate potential (CHIP)6 . Simultaneous analyses of germline and somatic whole-genome sequences provide the opportunity to identify root causes of CHIP...
October 2020: Nature
#30
JOURNAL ARTICLE
George Gifford, Nicolas Crossley, Sarah Morgan, Matthew J Kempton, Paola Dazzan, Gemma Modinos, Matilda Azis, Carly Samson, Ilaria Bonoldi, Beverly Quinn, Sophie E Smart, Mathilde Antoniades, Matthijs G Bossong, Matthew R Broome, Jesus Perez, Oliver D Howes, James M Stone, Paul Allen, Anthony A Grace, Philip McGuire
The ability to identify biomarkers of psychosis risk is essential in defining effective preventive measures to potentially circumvent the transition to psychosis. Using samples of people at clinical high risk for psychosis (CHR) and Healthy controls (HC) who were administered a task fMRI paradigm, we used a framework for labelling time windows of fMRI scans as 'integrated' FC networks to provide a granular representation of functional connectivity (FC). Periods of integration were defined using the 'cartographic profile' of time windows and k-means clustering, and sub-network discovery was carried out using Network Based Statistics (NBS)...
October 13, 2020: Human Brain Mapping
#31
JOURNAL ARTICLE
Xihao Li, Zilin Li, Hufeng Zhou, Sheila M Gaynor, Yaowu Liu, Han Chen, Ryan Sun, Rounak Dey, Donna K Arnett, Stella Aslibekyan, Christie M Ballantyne, Lawrence F Bielak, John Blangero, Eric Boerwinkle, Donald W Bowden, Jai G Broome, Matthew P Conomos, Adolfo Correa, L Adrienne Cupples, Joanne E Curran, Barry I Freedman, Xiuqing Guo, George Hindy, Marguerite R Irvin, Sharon L R Kardia, Sekar Kathiresan, Alyna T Khan, Charles L Kooperberg, Cathy C Laurie, X Shirley Liu, Michael C Mahaney, Ani W Manichaikul, Lisa W Martin, Rasika A Mathias, Stephen T McGarvey, Braxton D Mitchell, May E Montasser, Jill E Moore, Alanna C Morrison, Jeffrey R O'Connell, Nicholette D Palmer, Akhil Pampana, Juan M Peralta, Patricia A Peyser, Bruce M Psaty, Susan Redline, Kenneth M Rice, Stephen S Rich, Jennifer A Smith, Hemant K Tiwari, Michael Y Tsai, Ramachandran S Vasan, Fei Fei Wang, Daniel E Weeks, Zhiping Weng, James G Wilson, Lisa R Yanek, Benjamin M Neale, Shamil R Sunyaev, Gonçalo R Abecasis, Jerome I Rotter, Cristen J Willer, Gina M Peloso, Pradeep Natarajan, Xihong Lin
Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association tests have limited scope to leverage variant functions. We propose STAAR (variant-set test for association using annotation information), a scalable and powerful RV association test method that effectively incorporates both variant categories and multiple complementary annotations using a dynamic weighting scheme. For the latter, we introduce 'annotation principal components', multidimensional summaries of in silico variant annotations...
September 2020: Nature Genetics
#32
JOURNAL ARTICLE
Michael D Wolcott, Matthew R Mason, Angela M Broome, Ashley J Tittemore, Scott S De Rossi, Rocio B Quinonez
PURPOSE: The entrustable professional activity (EPA) framework is an assessment approach used to define the educational outcomes of a program by outlining discrete work tasks learners are expected to perform independently upon graduation. This study outlines the development and evaluation of an EPA framework for predoctoral dental education at the University of North Carolina Adams School of Dentistry. METHODS: The draft EPA framework was created in collaboration with a group of faculty members and included 15 statements that were mapped to relevant Commission on Dental Accreditation standards...
September 2020: Journal of Dental Education
#33
MULTICENTER STUDY
Anthony R Mato, Lindsey E Roeker, Nicole Lamanna, John N Allan, Lori Leslie, John M Pagel, Krish Patel, Anders Osterborg, Daniel Wojenski, Manali Kamdar, Scott F Huntington, Matthew S Davids, Jennifer R Brown, Darko Antic, Ryan Jacobs, Inhye E Ahn, Jeffrey Pu, Krista M Isaac, Paul M Barr, Chaitra S Ujjani, Mark B Geyer, Ellin Berman, Andrew D Zelenetz, Nikita Malakhov, Richard R Furman, Michael Koropsak, Neil Bailey, Lotta Hanson, Guilherme F Perini, Shuo Ma, Christine E Ryan, Adrian Wiestner, Craig A Portell, Mazyar Shadman, Elise A Chong, Danielle M Brander, Suchitra Sundaram, Amanda N Seddon, Erlene Seymour, Meera Patel, Nicolas Martinez-Calle, Talha Munir, Renata Walewska, Angus Broom, Harriet Walter, Dima El-Sharkawi, Helen Parry, Matthew R Wilson, Piers E M Patten, José-Ángel Hernández-Rivas, Fatima Miras, Noemi Fernández Escalada, Paola Ghione, Chadi Nabhan, Sonia Lebowitz, Erica Bhavsar, Javier López-Jiménez, Daniel Naya, Jose Antonio Garcia-Marco, Sigrid S Skånland, Raul Cordoba, Toby A Eyre
Given advanced age, comorbidities, and immune dysfunction, chronic lymphocytic leukemia (CLL) patients may be at particularly high risk of infection and poor outcomes related to coronavirus disease 2019 (COVID-19). Robust analysis of outcomes for CLL patients, particularly examining effects of baseline characteristics and CLL-directed therapy, is critical to optimally manage CLL patients through this evolving pandemic. CLL patients diagnosed with symptomatic COVID-19 across 43 international centers (n = 198) were included...
September 3, 2020: Blood
#34
RANDOMIZED CONTROLLED TRIAL
Anthony P Morrison, Melissa Pyle, Daniel Maughan, Louise Johns, Daniel Freeman, Matthew R Broome, Nusrat Husain, David Fowler, Jemma Hudson, Graeme MacLennan, John Norrie, David Shiers, Chris Hollis, Anthony James
BACKGROUND: Evidence for the effectiveness of treatments in early-onset psychosis is sparse. Current guidance for the treatment of early-onset psychosis is mostly extrapolated from trials in adult populations. The UK National Institute for Health and Care Excellence has recommended evaluation of the clinical effectiveness and cost-effectiveness of antipsychotic drugs versus psychological intervention (cognitive behavioural therapy [CBT] and family intervention) versus the combination of these treatments for early-onset psychosis...
September 2020: Lancet Psychiatry
#35
JOURNAL ARTICLE
Isabel Morales-Muñoz, Matthew R Broome, Steven Marwaha
Importance: Persistent nightmares in childhood have been prospectively associated with psychosis and borderline personality disorder (BPD) in adolescence. However, the extent to which this association is also true for behavioral sleep problems is still unknown, and the potential mechanisms are unexplored. Objective: To examine the prospective associations between several parent-reported sleep problems in early childhood and psychotic and BPD symptoms at 11 to 13 years of age and the potential mediation of the associations by depression at 10 years of age...
July 1, 2020: JAMA Psychiatry
#36
JOURNAL ARTICLE
Helen Bould, Katharine Noonan, Ian Penton-Voak, Andy Skinner, Marcus R Munafò, Rebecca J Park, Matthew R Broome, Catherine J Harmer
Body dissatisfaction is associated with subsequent eating disorders and weight gain. One-off exposure to bodies of different sizes changes perception of others' bodies, and perception of and satisfaction with own body size. The effect of repeated exposure to bodies of different sizes has not been assessed. We randomized women into three groups, and they spent 5 min twice a day for a week completing a one-back task using images of women modified to appear either under, over, or neither over- nor underweight...
April 2020: Royal Society Open Science
#37
JOURNAL ARTICLE
Jack C Rogers, Matthew R Broome
No abstract text is available yet for this article.
May 2020: Lancet Psychiatry
#38
JOURNAL ARTICLE
Gemma Modinos, Paul Allen, Andre Zugman, Danai Dima, Matilda Azis, Carly Samson, Ilaria Bonoldi, Beverly Quinn, George W G Gifford, Sophie E Smart, Mathilde Antoniades, Matthijs G Bossong, Matthew R Broome, Jesus Perez, Oliver D Howes, James M Stone, Anthony A Grace, Philip McGuire
Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this model in people at clinical high risk (CHR) for psychosis according to their subsequent clinical outcomes. Seventy-six CHR participants as defined using the Comprehensive Assessment of At-Risk Mental States (CAARMS) and 31 healthy controls (HC) were studied while performing a novelty salience fMRI task that engaged an a priori hippocampal-striatal-midbrain circuit of interest...
September 18, 2019: Schizophrenia Bulletin
#39
JOURNAL ARTICLE
Isabel Morales-Muñoz, Sakari Lemola, Outi Saarenpää-Heikkilä, Anneli Kylliäinen, Pirjo Pölkki, Tiina Paunio, Matthew R Broome, E Juulia Paavonen
Background: The concurrence of sleep and socio-emotional development in children is well accepted. However, the predictive role of sleep problems in infancy and the development of emotional and behavioural problems later in childhood remain still unclear. Therefore, in this study we examined the associations between sleep problems in early childhood and internalising, externalising and dysregulation symptoms in toddlers. Methods: 1679 families entered the study during pregnancy and 936 children participated at 24 months...
2020: BMJ Paediatrics Open
#40
REVIEW
Clara S Humpston, Matthew R Broome
In this Personal View, we discuss the history and concept of self-disturbance in relation to the pathophysiology and subjective experience of schizophrenia in terms of three approaches: the perceptual anomalies approach of the early Heidelberg School of Psychiatry, the ipseity model, and the predictive coding framework. Despite the importance of these approaches, there has been a notable absence of efforts to compare them and consider how they might be integrated. This Personal View compares the three approaches and offers suggestions as to how they might work together, which represents a novel position...
July 2020: Lancet Psychiatry
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