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matthew r broome

Giusi Moffa, Gennaro Catone, Jack Kuipers, Elizabeth Kuipers, Daniel Freeman, Steven Marwaha, Belinda R Lennox, Matthew R Broome, Paul Bebbington
Modern psychiatric epidemiology researches complex interactions between multiple variables in large datasets. This creates difficulties for causal inference. We argue for the use of probabilistic models represented by directed acyclic graphs (DAGs). These capture the dependence structure of multiple variables and, used appropriately, allow more robust conclusions about the direction of causation. We analyzed British national survey data to assess putative mediators of the association between bullying victimization and persecutory ideation...
May 17, 2017: Schizophrenia Bulletin
Angharad N de Cates, Karen Rees, Fabrice Jollant, Benjamin Perry, Karina Bennett, Katie Joyce, Eimear Leyden, Catherine Harmer, Keith Hawton, Kees van Heeringen, Matthew R Broome
BACKGROUND: Prediction of self-harm is limited clinically. Early identification of individuals likely to repeat self-harm could improve outcomes and reduce suicide risk. Various neurocognitive deficits have been found in people who self-harm, but the ability of these to predict repetition has yet to be established AIMS: Identify neurocognitive factors that may predict repetition of self-harm. METHODS: Systematic narrative review of English language publications assessing neurocognitive functioning and self-harm repetition, searching multiple databases from inception to March 2015...
January 2017: Neuroscience and Biobehavioral Reviews
Rachel Upthegrove, Jonathan Ives, Matthew R Broome, Kimberly Caldwell, Stephen J Wood, Femi Oyebode
BACKGROUND: In dimensional understanding of psychosis, auditory verbal hallucinations (AVH) are unitary phenomena present on a continuum from non-clinical voice hearing to severe mental illness. There is mixed evidence for this approach and a relative absence of research into subjective experience of AVH in early psychosis. AIMS: To conduct primary research into the nature of subjective experience of AVH in first-episode psychosis. METHOD: A phenomenological study using diary and photo-elicitation qualitative techniques investigating the subjective experience of AVH in 25 young people with first-episode psychosis...
January 2016: BJPsych Open
Irina Falkenberg, Isabel Valli, Marie Raffin, Matthew R Broome, Paolo Fusar-Poli, Pall Matthiasson, Marco Picchioni, Philip McGuire
BACKGROUND: Clinical outcomes in people identified as at ultra-high risk (UHR) for psychosis are remarkably heterogeneous, and are difficult to predict on the basis of the presenting clinical features. Individuals at UHR are at risk of poor functional outcome regardless of development of psychotic disorder. The aim of the present study was to assess whether there is a relationship between functional neuroimaging measures at presentation and functional outcome as measured by the GAF three years after scanning...
September 29, 2016: Schizophrenia Research
Steven Marwaha, Andrew Thompson, Rachel Upthegrove, Matthew R Broome
Early intervention for psychosis (EIP) is a model of service delivery that aims to support young people with first-episode psychosis by providing the best available treatments, supporting recovery and preventing relapse. In this editorial, we review the evidence for EIP, how the model has developed since its inclusion in the NHS policy implementation guideline for mental health in 2001, challenges and areas of ongoing debate, and future development.
September 2016: British Journal of Psychiatry: the Journal of Mental Science
Tao Li, Qiang Wang, Jie Zhang, Edmund T Rolls, Wei Yang, Lena Palaniyappan, Lu Zhang, Wei Cheng, Ye Yao, Zhaowen Liu, Xiaohong Gong, Qiang Luo, Yanqing Tang, Timothy J Crow, Matthew R Broome, Ke Xu, Chunbo Li, Jijun Wang, Zhening Liu, Guangming Lu, Fei Wang, Jianfeng Feng
Published reports of functional abnormalities in schizophrenia remain divergent due to lack of staging point-of-view and whole-brain analysis. To identify key functional-connectivity differences of first-episode (FE) and chronic patients from controls using resting-state functional MRI, and determine changes that are specifically associated with disease onset, a clinical staging model is adopted. We analyze functional-connectivity differences in prodromal, FE (mostly drug naïve), and chronic patients from their matched controls from 6 independent datasets involving a total of 789 participants (343 patients)...
March 1, 2017: Schizophrenia Bulletin
Julie Eyden, Catherine Winsper, Dieter Wolke, Matthew R Broome, Fiona MacCallum
There is growing interest in whether the parenting strategies and offspring outcomes of mothers with borderline personality disorder (BPD) differ from those of mothers without BPD. We searched PsychINFO, PubMed, EMBASE, Web of Science, Scopus and ASSIA databases for studies examining parenting skills and attitudes among mothers with BPD/BPD symptoms and/or offspring outcomes. PRISMA reporting guidelines were followed. Of 10,067 abstracts screened, 101 full-text articles were retrieved and 33 met pre-determined criteria for qualitative synthesis...
July 2016: Clinical Psychology Review
Angharad N de Cates, Matthew R Broome
Over 800,000 people die by suicide each year globally, with non-fatal self-harm 20 times more common. With each episode of self-harm, the risks of future self-harm and suicide increase, as well as personal and healthcare costs. Therefore, early delineation of those at high risk of future self-harm is important. Historically, research has focused on clinical and demographic factors, but risk assessments based on these have low sensitivity to predict repetition. Various neurocognitive factors have been associated with self-harming behavior, but it is less certain if we can use these factors clinically (i) as risk markers to predict future self-harm and (ii) to become therapeutic targets for interventions...
2016: Frontiers in Psychiatry
Mark Toynbee, Adam Aj Al-Diwani, Joe Clacey, Matthew R Broome
An impasse in negotiations between the Department of Health (DoH) and the British Medical Association in November this year led to an overwhelming vote for industrial action (IA) by junior doctors. At the time of writing, a last minute concession by DoH led to a deferment of IA to allow further negotiations mediated by the Advisory, Conciliation and Arbitration Service. However, IA by junior doctors remains a possibility if these negotiations stall again. Would the proposed action be ethically justifiable? Furthermore, is IA by doctors ever ethically defendable? Building on previous work, we explore important ethical considerations for doctors considering IA...
March 2016: Journal of Medical Ethics
Madiha Majid, Maria Tadros, George Tadros, Swaran Singh, Matthew R Broome, Rachel Upthegrove
PURPOSE: To explore repetition, service provision and service engagement following presentation of young people to emergency services with self-harm. METHODS: 969 patients who presented to accident and emergency services after self-harm were followed up prospectively for a period of 1 year. Data on rates, method, clinical history, initial service provision, engagement and repetition (defined as re-presenting to emergency services with further self-harm) were gathered from comprehensive electronic records...
February 2016: Social Psychiatry and Psychiatric Epidemiology
Matthew A Broom, Amy S Ladley, Elizabeth A Rhyne, Donna R Halloran
BACKGROUND: Postpartum depression (PPD) is the most common medical problem among new mothers that can have a negative impact on infant health. Traditional treatments are often difficult for low-income mothers to complete, particularly given the numerous barriers families face. OBJECTIVE: Among low-income, primarily racial, and ethnic minority mothers with postpartum depression, our aim was to evaluate (1) the feasibility of sending supportive text messages, and (2) the perception of receiving private, supportive text messages for postpartum depression...
January 2015: JMIR Mental Health
Ronen Durst, Kimberly Sauls, David S Peal, Annemarieke deVlaming, Katelynn Toomer, Maire Leyne, Monica Salani, Michael E Talkowski, Harrison Brand, Maëlle Perrocheau, Charles Simpson, Christopher Jett, Matthew R Stone, Florie Charles, Colby Chiang, Stacey N Lynch, Nabila Bouatia-Naji, Francesca N Delling, Lisa A Freed, Christophe Tribouilloy, Thierry Le Tourneau, Hervé LeMarec, Leticia Fernandez-Friera, Jorge Solis, Daniel Trujillano, Stephan Ossowski, Xavier Estivill, Christian Dina, Patrick Bruneval, Adrian Chester, Jean-Jacques Schott, Kenneth D Irvine, Yaopan Mao, Andy Wessels, Tahirali Motiwala, Michel Puceat, Yoshikazu Tsukasaki, Donald R Menick, Harinath Kasiganesan, Xingju Nie, Ann-Marie Broome, Katherine Williams, Amanda Johnson, Roger R Markwald, Xavier Jeunemaitre, Albert Hagege, Robert A Levine, David J Milan, Russell A Norris, Susan A Slaugenhaupt
Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 individuals. It can manifest as mitral regurgitation and is the leading indication for mitral valve surgery. Despite a clear heritable component, the genetic aetiology leading to non-syndromic MVP has remained elusive. Four affected individuals from a large multigenerational family segregating non-syndromic MVP underwent capture sequencing of the linked interval on chromosome 11. We report a missense mutation in the DCHS1 gene, the human homologue of the Drosophila cell polarity gene dachsous (ds), that segregates with MVP in the family...
September 3, 2015: Nature
Steven Marwaha, Andrew Thompson, Paul Bebbington, Swaran P Singh, Daniel Freeman, Catherine Winsper, Matthew R Broome
Despite both having some shared features, evidence linking psychosis and adult attention deficit hyperactivity disorder (ADHD) is sparse and inconsistent. Hypotheses tested were (1) adult ADHD symptoms are associated with auditory hallucinations, paranoid ideation and psychosis (2) links between ADHD symptoms and psychosis are mediated by prescribed ADHD medications, use of illicit drugs, and dysphoric mood. The Adult Psychiatric Morbidity Survey 2007 (N=7403) provided data for regression and multiple mediation analyses...
September 30, 2015: Psychiatry Research
Gregory T Adamson, Lauren R Draper, Matthew A Broom
BACKGROUND: There is an ongoing effort to maximize educational material provided to residents who are in a time-constrained work environment. Mobile technology, principally smartphone applications and online modules, has shown educational promise. INTERVENTION: We developed a text-messaging program, Text4Peds, to assist residents with preparation for their pediatric board examinations. Goals were to assess (1) the feasibility of texting educational messages to residents, and (2) resident satisfaction and perceived usefulness of a texting program...
December 2014: Journal of Graduate Medical Education
Matthew R Broome, Angharad de Cates
No abstract text is available yet for this article.
August 2015: Journal of Medical Ethics
Lucia R Valmaggia, Majella Byrne, Fern Day, Matthew R Broome, Louise Johns, Oliver Howes, Paddy Power, Steven Badger, Paolo Fusar-Poli, Philip K McGuire
BACKGROUND: It is unknown whether prodromal services improve outcomes in those who go on to develop psychosis, and whether these patients are demographically different from the overall first-episode population. AIMS: To compare sociodemographic features, duration of untreated psychosis, hospital admission and frequency of compulsory treatment in the first year after the onset of psychosis in patients who present to prodromal services with patients who did not present to services until the first episode of psychosis...
August 2015: British Journal of Psychiatry: the Journal of Mental Science
Matthew R Broome, Zhimin He, Mashal Iftikhar, Julie Eyden, Steven Marwaha
OBJECTIVES: To evaluate the neurobiological, psychophysical and behavioural measures of affective instability in clinical populations. DATA SOURCES: A range of medical and psychological science electronic databases were searched (including MEDLINE, EMBASE, and PsycINFO). Hand searching and reference checking are also included. REVIEW METHODS: Reviews, systematic reviews, experimental and cross-sectional studies, providing affective instability in neurobiological and behavioural measurements in clinical populations...
April 2015: Neuroscience and Biobehavioral Reviews
Madiha Shaikh, Anirban Dutt, Matthew R Broome, Alberto G Vozmediano, Siri Ranlund, Alvaro Diez, Olalla Caseiro, Julia Lappin, Susan Amankwa, Francesco Carletti, Paolo Fusar-Poli, Muriel Walshe, Mei-Hua Hall, Oliver Howes, Lyn Ellett, Robin M Murray, Philip McGuire, Lucia Valmaggia, Elvira Bramon
BACKGROUND: Individuals with an "Attenuated Psychosis Syndrome" (APS) have a 20-40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis. METHOD: 36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning-testing experiment while their electroencephalogram was recorded...
February 2015: Schizophrenia Research
Lisa Bortolotti, Matthew R Broome, Matteo Mameli
What factors should be taken into account when attributing criminal responsibility to perpetrators of severe crimes? We discuss the Breivik case, and the considerations which led to holding Breivik accountable for his criminal acts. We put some pressure on the view that experiencing certain psychiatric symptoms or receiving a certain psychiatric diagnosis is sufficient to establish criminal insanity. We also argue that the presence of delusional beliefs, often regarded as a key factor in determining responsibility, is neither necessary nor sufficient for criminal insanity...
2014: Neuroethics
Kate Stein, Matthew R Broome
No abstract text is available yet for this article.
February 2015: Australian and New Zealand Journal of Psychiatry
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