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https://www.readbyqxmd.com/read/28320067/patterns-of-low-acuity-patient-presentations-to-emergency-departments-in-new-south-wales-australia
#1
Alexandre S Stephens, Richard A Broome
OBJECTIVE: To explore the patterns of low acuity patient (LAP) presentations to EDs in New South Wales (NSW), Australia. METHODS: Retrospective study of NSW public hospital ED presentations between January 2013 and December 2014 that were registered in the NSW Emergency Department Data Collection (n = 409 035). LAPs were defined according to the Australian Institute of Health and Welfare (AIHW), Sprivulis and multiple ACEM methods. Multivariable logistic regression was used to assess the adjusted odds of LAP ED presentation by a suite of sociodemographic factors...
March 20, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28317747/physicochemical-characteristics-and-pollen-spectrum-of-monofloral-honeys-from-tenerife-spain
#2
Antonio Bentabol Manzanares, Zoa Hernández García, Beatriz Rodríguez Galdón, Elena M Rodríguez-Rodríguez, Carlos Díaz Romero
Physicochemical parameters, sugar composition and botanical origin were determined in four monofloral honeys, chestnut, fennel, tajinaste, and Teide broom honeys, abundantly produced in Tenerife Island. All the parameters were within the established intervals in Europe for each type of honey. Large differences between the four monofloral honeys were observed, being the chestnut honeys with most of differential characteristics. Linear discriminant analysis on the physicochemical parameters and sugar composition allows to distinguishing the four types of honeys analysed...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28289044/exploiting-social-influence-to-magnify-population-level-behaviour-change-in-maternal-and-child-health-study-protocol-for-a-randomised-controlled-trial-of-network-targeting-algorithms-in-rural-honduras
#3
Holly B Shakya, Derek Stafford, D Alex Hughes, Thomas Keegan, Rennie Negron, Jai Broome, Mark McKnight, Liza Nicoll, Jennifer Nelson, Emma Iriarte, Maria Ordonez, Edo Airoldi, James H Fowler, Nicholas A Christakis
INTRODUCTION: Despite global progress on many measures of child health, rates of neonatal mortality remain high in the developing world. Evidence suggests that substantial improvements can be achieved with simple, low-cost interventions within family and community settings, particularly those designed to change knowledge and behaviour at the community level. Using social network analysis to identify structurally influential community members and then targeting them for intervention shows promise for the implementation of sustainable community-wide behaviour change...
March 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28256604/hydraulic-forces-contribute-to-left-ventricular-diastolic-filling
#4
Elira Maksuti, Marcus Carlsson, Håkan Arheden, Sándor J Kovács, Michael Broomé, Martin Ugander
Myocardial active relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function. We hypothesize the existence of an additional mechanism involved in LV filling, namely, a hydraulic force contributing to the longitudinal motion of the atrioventricular (AV) plane. A prerequisite for the presence of a net hydraulic force during diastole is that the atrial short-axis area (ASA) is smaller than the ventricular short-axis area (VSA). We aimed (a) to illustrate this mechanism in an analogous physical model, (b) to measure the ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonance imaging, and (c) to calculate the magnitude of the hydraulic force...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28254206/discontinuing-vegf-targeted-therapy-for-progression-versus-toxicity-affects-outcomes-of-second-line-therapies-in-metastatic-renal-cell%C3%A2-carcinoma
#5
Guillermo De Velasco, Wanling Xie, Frede Donskov, Laurence Albiges, Benoit Beuselinck, Sandy Srinivas, Neeraj Agarwal, Jae Lyun Lee, James Brugarolas, Lori A Wood, Sun-Young Rha, Christian Kollmannsberger, Scott North, Ravindran Kanesvaran, Brian I Rini, Reuben Broom, Haru Yamamoto, Marina D Kaymakcalan, Daniel Y C Heng, Toni K Choueiri
BACKGROUND: A significant subgroup of metastatic renal cell carcinoma (mRCC) patients discontinue vascular endothelial growth factor-targeted therapies (VEGF-TT) because of toxicity. Whether clinical outcomes differ in patients who receive second-line (2L) targeted therapy on the basis of reason for discontinuation of first-line (1L) therapy is unknown. PATIENTS AND METHODS: Patients from 15 International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) centers who started 2L targeted therapy were included and the reason for discontinuation of 1L therapy retrospectively collected...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28246280/the-handle-of-the-broom
#6
EDITORIAL
Derek S Wheeler
No abstract text is available yet for this article.
March 2017: Respiratory Care
https://www.readbyqxmd.com/read/28228262/targeting-dna-damage-response-in-prostate-cancer-by-inhibiting-androgen-receptor-cdc6-atr-chk1-signaling
#7
Styliani Karanika, Theodoros Karantanos, Likun Li, Jianxiang Wang, Sanghee Park, Guang Yang, Xuemei Zuo, Jian H Song, Sankar N Maity, Ganiraju C Manyam, Bradley Broom, Ana M Aparicio, Gary E Gallick, Patricia Troncoso, Paul G Corn, Nora Navone, Wei Zhang, Shuhua Li, Timothy C Thompson
Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa tissues. AR or CDC6 knockdown, together with AZD7762, a Chk1/2 inhibitor, results in decreased TopBP1-ATR-Chk1 signaling and markedly increased ataxia-telangiectasia-mutated (ATM) phosphorylation, a biomarker of DNA damage, and synergistically increases treatment efficacy...
February 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28207982/understanding-ethical-issues-of-research-participation-from-the-perspective-of-participating-children-and-adolescents-a-systematic-review
#8
Stacey Crane, Marion E Broome
BACKGROUND: The past 20 years have seen distinct shifts in the way the participation of children and adolescents in research is viewed. This has been emphasized by the growing pediatric research enterprise. Additional information on children's and adolescents' experiences during research participation is needed to better inform researchers on the ethical conduct of research with this vulnerable population. AIMS: The objective of this analysis was to examine ethical issues in research with children and adolescents from their perspective as participants, including: assent, parental consent, risk perception, impact of research participation, and incentives...
February 16, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28199881/the-influence-of-early-degenerative-changes-on-the-vulnerability-of-articular-cartilage-to-impact-induced-injury
#9
Joshua Workman, Ashvin Thambyah, Neil Broom
BACKGROUND: Recently, the structural changes in a bovine model of early degeneration were validated by our research group to be analogous to that in early human osteoarthritis. The hypothesis of this study was that the structural changes associated with increasing levels of degeneration would lead to higher levels of tissue damage in response to impact induced injury. METHODS: A total of forty bovine patellae were obtained for this study. Cartilage-on-bone samples were extracted from the distal lateral quarter, a region known to be affected by varying levels of degeneration...
January 4, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28193572/systematic-review-of-early-and-long-term-outcome-of-liver-resection-for-metastatic-breast-cancer-is-there-a-survival-benefit
#10
REVIEW
Tae Gon Yoo, Isaac Cranshaw, Reuben Broom, Sanjay Pandanaboyana, Adam Bartlett
BACKGROUND: Isolated liver metastases occur rarely in patients with metastatic breast cancer. The success of liver resection (LR) for other metastatic disease has led centres to explore the option of LR for patients with isolated breast cancer liver metastases (BCLM). A number of small series have been published in the literature, however the evidence is conflicting. This study aimed to systematically review the literature to determine the perioperative outcome and survival of patients undergoing LR for BCLM...
April 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28169035/integration-of-parent-and-nurse-perspectives-of-communication-to-plan-care-for-technology-dependent-children-the-theory-of-shared-communication
#11
Barbara K Giambra, Marion E Broome, Teresa Sabourin, Janice Buelow, Deborah Stiffler
PURPOSE: The purpose of this qualitative research study was to expand our understanding of the process of communication between parents of hospitalized technology dependent children and their nurses originally detailed in the Theory of Shared Communication (TSC). DESIGN AND METHODS: This grounded theory study was conducted with five parents of technology dependent children hospitalized in a large Midwestern children's hospital and nine nurses who care for technology dependent children admitted to the same hospital during July and August 2013...
February 3, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28164783/shaping-the-rn-workforce-for-primary-care
#12
EDITORIAL
Marion E Broome
No abstract text is available yet for this article.
January 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28160724/exploring-the-relationships-between-protein-sequence-structure-and-solubility
#13
REVIEW
Kyle Trainor, Aron Broom, Elizabeth M Meiering
Aggregation can be thought of as a form of protein folding in which intermolecular associations lead to the formation of large, insoluble assemblies. Various types of aggregates can be differentiated by their internal structures and gross morphologies (e.g., fibrillar or amorphous), and the ability to accurately predict the likelihood of their formation by a given polypeptide is of great practical utility in the fields of biology (including the study of disease), biotechnology, and biomaterials research. Here we review aggregation/solubility prediction methods and selected applications thereof...
February 1, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28159021/ebola-outbreak-preparedness-planning-a-qualitative-study-of-clinicians-experiences
#14
J Broom, A Broom, V Bowden
OBJECTIVES: The 2014-15 Ebola outbreak in West Africa highlighted the challenges many hospitals face when preparing for the potential emergence of highly contagious diseases. This study examined the experiences of frontline health care professionals in an Australian hospital during the outbreak, with a focus on participant views on information, training and preparedness, to inform future outbreak preparedness planning. STUDY DESIGN: Semi-structured interviews were conducted with 21 healthcare professionals involved in Ebola preparedness planning, at a hospital in Australia...
February 2017: Public Health
https://www.readbyqxmd.com/read/28150209/fluorescence-and-bioluminescence-imaging-of-orthotopic-brain-tumors-in-mice
#15
Emilie McKinnon, Alfred Moore, Suraj Dixit, Yun Zhu, Ann-Marie Broome
Optical imaging strategies, such as fluorescence and bioluminescence imaging, are non-invasive, in vivo whole body imaging techniques utilized to study cancer. Optical imaging is widely used in preclinical work because of its ease of use and cost-friendliness. It also provides the opportunity to study animals and biological responses longitudinally over time. Important considerations include depth of tissue penetration, photon scattering, absorption and the choice of light emitting probe, all of which affect the resolution (image quality and data information) and the signal to noise ratio of the image...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28139858/geographic-and-socioeconomic-factors-in-patients-with-malignant-pleural-mesothelioma-in-new-south-wales-and-their-impact-upon-clinical-outcomes
#16
Anthony Linton, Matthew Soeberg, Richard Broome, Steven Kao, Nico van Zandwijk
BACKGROUND AND OBJECTIVE: Whilst the impact of clinicopathological factors on the prognosis of malignant pleural mesothelioma (MPM) is well understood, socioeconomic and geographic factors have received less attention. We analysed the relationship between geographic and socioeconomic factors upon survival and treatment provision in a large series of patients with MPM. METHODS: We assessed MPM patients awarded compensation between 2002 and 2009 with additional MPM incidence data from the New South Wales (NSW) Cancer Registry...
January 31, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28115346/targeting-alpha-toxin-to-mitigate-its-lethal-toxicity-in-ferret-and-rabbit-models-of-staphylococcus-aureus-necrotizing-pneumonia
#17
Binh An Diep, Jamese J Hillard, Vien T M Le, Christine Tkaczyk, Hoan N Le, Vuvi G Tran, Renee L Rao, Etyene Castro Dip, Eliane P Pereira-Franchi, Paulyn Cha, Scott Jacobson, Rosemary Broome, Lily I Cheng, William Weiss, Laszlo Prokai, Vien Nguyen, C Ken Stover, Bret R Sellman
The role broad spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome have led to advances in pathogen specific approaches for the prevention or treatment of serious bacterial infections. One approach in clinical testing is passive immunization with a monoclonal antibody (mAb) targeting alpha toxin for the prevention or treatment of Staphylococcus aureus pneumonia. Passive immunization with the human anti-alpha toxin mAb, MEDI4893* has been shown to improve disease outcome in murine S...
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28114261/refinement-of-a-conceptual-model-for-adolescent-readiness-to-engage-in-end-of-life-discussions
#18
Cynthia J Bell, Gregory D Zimet, Pamela S Hinds, Marion E Broome, Anna M McDaniel, Rose M Mays, Victoria L Champion
BACKGROUND: Adolescents living with incurable cancer require ongoing support to process grief, emotions, and information as disease progresses including treatment options (phase 1 clinical trials and/or hospice/palliative care). Little is known about how adolescents become ready for such discussions. OBJECTIVE: The purpose of this study was to explore the process of adolescent readiness for end-of-life preparedness discussions, generating a theoretical understanding for guiding clinical conversations when curative options are limited...
January 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28087366/a-program-to-prevent-burnout-depression-and-anxiety-in-first-year-pediatric-residents
#19
Stuart Slavin, Mindy Shoss, Matthew A Broom
No abstract text is available yet for this article.
January 10, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28078778/texting-preferences-in-a-paediatric-residency
#20
Lauren Draper, Cadence Kuklinski, Amy Ladley, Greg Adamson, Matthew Broom
PURPOSE: Text messaging is ubiquitous among residents, but remains an underused educational tool. Though feasibility has been demonstrated, evidence of its ability to improve standardised test scores and provide insight on resident texting preferences is lacking. The authors set out to evaluate: (1) satisfaction with a hybrid question-and-answer (Q&A) texting format; and (2) pre-/post-paediatric in-training exam (ITE) performance. METHODS: A prospective study with paediatrics and internal medicine-paediatrics residents...
January 12, 2017: Clinical Teacher
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