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https://www.readbyqxmd.com/read/29138344/targeting-the-mycn-parp-dna-damage-response-pathway-inneuroendocrine-prostate-cancer
#1
Wei Zhang, Bo Liu, Wenhui Wu, Likun Li, Bradley M Broom, Spyridon M Basourakos, Dimitrios Korentzelos, Yang Luan, Jianxiang Wang, Guang Yang, Sanghee Park, Abul K Azad, Xuhong Cao, Jeri Kim, Paul Corn, Christopher Logothetis, Ana M Aparicio, Arul M Chinnayan, Nora M Navone, Patricia Troncoso, Timothy C Thompson
PURPOSE: We investigated MYCN-regulated molecular pathways in castration-resistant prostate cancer (CRPC) classified by morphological criteria as adenocarcinoma or neuroendocrine to extend the molecular phenotype, establish driver pathways, and identify novel approaches to combination therapy for NEPC. RESULTS: Using comparative bioinformatics analyses of CRPC-Adeno and CRPC-Neuro RNA sequence data from public datasets and a panel of 28 PDX models we identified a MYCN-PARP-DNA damage response (DDR) pathway that is enriched in CRPC with neuroendocrine differentiation (NED) and CRPC-Neuro...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29126317/inflammation-friend-or-foe-for-animal-production
#2
Leon J Broom, Michael H Kogut
Inflammation is an essential immune response that seeks to contain microbial infection and repair damaged tissue. Increased pro-inflammatory mediators have been associated with enhanced resistance to a range of important poultry and pig pathogens. However, inflammation may also have undesirable consequences, including potentially exacerbating tissue damage and diverting nutrients away from productive purposes. The negative effects of inflammation have led to the active pursuit of anti-inflammatory feed additives and/or strategies...
November 4, 2017: Poultry Science
https://www.readbyqxmd.com/read/29122393/how-do-professional-relationships-influence-surgical-antibiotic-prophylaxis-decision-making-a-qualitative-study
#3
Jennifer K Broom, Alex F Broom, Emma R Kirby, Jeffrey J Post
BACKGROUND: Surgical antibiotic prophylaxis (SAP) is a critical area to optimize to reduce the escalation of antimicrobial resistance. This article explores the ways by which interpersonal relationships influence SAP decision making. METHODS: Twenty surgeons and anesthetists participated in in-depth semistructured interviews on SAP prescribing. Results were analyzed using the framework approach. RESULTS: Analysis revealed 3 ways by which interpersonal relationships influence SAP: relationship dynamics between the surgeon and the anesthetist determine appropriateness of SAP, particularly operative risk ownership; perceived hierarchies within, and between, surgical and anesthetist specialties influence antibiotic prescribing decisions; and surgical distance from the antimicrobial stewardship team, which influences use of antimicrobial stewardship principles...
November 7, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29119653/a-social-ecological-framework-a-model-for-addressing-ethical-practice-in-nursing
#4
P M Davidson, C H Rushton, M Kurtz, B Wise, D Jackson, A Beaman, M Broome
AIMS AND OBJECTIVES: To develop a framework to enable discussion, debate and the formulation of interventions to address ethical issues in nursing practice. BACKGROUND: Social, cultural, political and economic drivers are rapidly changing the landscape of health care in our local environments but also in a global context. Increasingly, nurses are faced with a range of ethical dilemmas in their work. This requires investigation into the culture of health care systems and organisations to identify the root causes and address the barriers and enablers of ethical practice...
November 9, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29093005/dendritic-cells-enhance-polyfunctionality-of-adoptively-transferred-t-cells-which-target-cytomegalovirus-in-glioblastoma
#5
Elizabeth Reap, Carter M Suryadevara, Kristen A Batich, Luis Sanchez-Perez, Gary E Archer, Robert J Schmittling, Pamela K Norberg, James E Herndon, Patrick Healy, Kendra L Congdon, Patrick C Gedeon, Olivia C Campbell, Adam M Swartz, Katherine A Riccione, John S Yi, Mohammed K Hossain-Ibrahim, Anirudh Saraswathula, Smita K Nair, Anastasie M Dunn-Pirio, Taylor M Broome, Kent J Weinhold, Annick Desjardins, Gordana Vlahovic, Roger Mclendon, Allan H Friedman, Henry S Friedman, Darell D Bigner, Peter E Fecci, Duane A Mitchell, John H Sampson
Median survival for glioblastoma (GBM) remains <15 months. Human Cytomegalovirus (CMV) antigens have been identified in GBM but not normal brain, providing an unparalleled opportunity to subvert CMV antigens as tumor-specific immunotherapy targets. A recent trial in recurrent GBM patients demonstrated the potential clinical benefit of adoptive T cell therapy (ATCT) of CMV phosphoprotein 65 (pp65)-specific T cells. However, ex vivo analyses from this study found no change in the capacity of CMV pp65-specific T cells to gain multiple effector functions or polyfunctionality, which has been associated with superior antitumor efficacy...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29092932/a-galaxy-implementation-of-next-generation-clustered-heatmaps-for-interactive-exploration-of-molecular-profiling-data
#6
Bradley M Broom, Michael C Ryan, Robert E Brown, Futa Ikeda, Mark Stucky, David W Kane, James Melott, Chris Wakefield, Tod D Casasent, Rehan Akbani, John N Weinstein
Clustered heatmaps are the most frequently used graphics for visualization of molecular profiling data in biology. However, they are generally rendered as static, or only modestly interactive, images. We have now used recent advances in web technologies to produce interactive "next-generation" clustered heatmaps (NG-CHM) that enable extreme zooming and navigation without loss of resolution. NG-CHMs also provide link-outs to additional information sources and include other features that facilitate deep exploration of the biology behind the image...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29090642/aflatoxins-and-ochratoxin-a-in-different-cocoa-clones-theobroma-cacao-l-developed-in-the-southern-region-of-bahia-brazil
#7
Leonardo Fonseca Maciel, Ana Lúcia de Souza Madureira Felício, Lucas Caldeirão Rodrigues Miranda, Tassia Cavalcante Pires, Eliete da Silva Bispo, Elisa Yoko Hirooka
Brazil is the sixth largest producer of cocoa beans in the world, after Côte d'Ivoire, Ghana, Indonesia, Nigeria and Cameroon. The southern region of Bahia stands out as the country's largest producer, accounting for approximately 60% of production. Due to damage caused by infestation of the cocoa crop with the fungus Moniliophthora perniciosa, which causes "witch's broom disease", research in cocoa beans has led to the cloning of species that are resistant to the disease, however, there is little information about the development of other fungal genera in these clones, Aspergillus for example, which do not represent a phytopathogenicity problem but which can grow during the pre-processing of cocoa beans and produce mycotoxins...
November 1, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29090635/depression-at-work-authenticity-in-question-experiencing-concealing-and-revealing
#8
Damien Ridge, Alex Broom, Renata Kokanović, Sue Ziebland, Nicholas Hill
Australia and the United Kingdom have introduced policies to protect employees who experience mental illness, including depression. However, a better understanding of the experiential issues workers face (e.g. sense of moral failure) is needed for the provision of appropriate and beneficial support. We analysed 73 interviews from the United Kingdom and Australia where narratives of depression and work intersected. Participants encountered difficulties in being (and performing as if) 'authentic' at work, with depression contributing to confusions about the self...
October 1, 2017: Health (London)
https://www.readbyqxmd.com/read/29084273/genome-wide-identification-and-characterization-of-cacao-wrky-transcription-factors-and-analysis-of-their-expression-in-response-to-witches-broom-disease
#9
Dayanne Silva Monteiro de Almeida, Daniel Oliveira Jordão do Amaral, Luiz-Eduardo Del-Bem, Emily Bronze Dos Santos, Raner José Santana Silva, Karina Peres Gramacho, Michel Vincentz, Fabienne Micheli
Transcriptional regulation, led by transcription factors (TFs) such as those of the WRKY family, is a mechanism used by the organism to enhance or repress gene expression in response to stimuli. Here, we report on the genome-wide analysis of the Theobroma cacao WRKY TF family and also investigate the expression of WRKY genes in cacao infected by the fungus Moniliophthora perniciosa. In the cacao genome, 61 non-redundant WRKY sequences were found and classified in three groups (I to III) according to the WRKY and zinc-finger motif types...
2017: PloS One
https://www.readbyqxmd.com/read/29083997/exploring-parental-and-staff-perceptions-of-the-family-integrated-care-model-a-qualitative-focus-group-study
#10
Margaret Broom, Georgia Parsons, Hazel Carlisle, Zsuzsoka Kecskes
BACKGROUND: Family-integrated care (FICare) is an innovative model of care developed at Mount Sinai Hospital, Canada, to better integrate parents into the team caring for their infant in the neonatal intensive care unit (NICU). The effects of FICare on neonatal outcomes and parental anxiety were assessed in an international multicenter randomized trial. As an Australian regional level 3 NICU that was randomized to the intervention group, we aimed to explore parent and staff perceptions of the FICare program in our dual occupancy NICU...
October 27, 2017: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
https://www.readbyqxmd.com/read/29081329/treating-sleep-problems-in-young-people-at-ultra-high-risk-of-psychosis-a-feasibility-case-series
#11
Jonathan Bradley, Daniel Freeman, Eleanor Chadwick, Allison G Harvey, Bradley Mullins, Louise Johns, Bryony Sheaves, Belinda Lennox, Matthew Broome, Felicity Waite
BACKGROUND: Our view is that sleep disturbance may be a contributory causal factor in the development and maintenance of psychotic experiences. A recent series of randomized controlled intervention studies has shown that cognitive-behavioural approaches can improve sleep in people with psychotic experiences. However, the effects of psychological intervention for improving sleep have not been evaluated in young people at ultra-high risk of psychosis. Improving sleep might prevent later transition to a mental health disorder...
October 30, 2017: Behavioural and Cognitive Psychotherapy
https://www.readbyqxmd.com/read/29070444/linking-crop-structure-throughfall-soil-surface-conditions-runoff-and-soil-detachment-10-land-uses-analyzed-in-northern-laos
#12
Guillaume Lacombe, Christian Valentin, Phabvilay Sounyafong, Anneke de Rouw, Bounsamai Soulileuth, Norbert Silvera, Alain Pierret, Oloth Sengtaheuanghoung, Olivier Ribolzi
In Montane Southeast Asia, deforestation and unsuitable combinations of crops and agricultural practices degrade soils at an unprecedented rate. Typically, smallholder farmers gain income from "available" land by replacing fallow or secondary forest by perennial crops. We aimed to understand how these practices increase or reduce soil erosion. Ten land uses were monitored in Northern Laos during the 2015 monsoon, using local farmers' fields. Experiments included plots of the conventional system (food crops and fallow), and land uses corresponding to new market opportunities (e...
October 22, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29060119/the-role-of-nonlinear-coupling-in-human-horse-interaction-a-preliminary-study
#13
Antonio Lanata, Andrea Guidi, Gaetano Valenza, Paolo Baragli, Enzo Pasquale Scilingo
This study focuses on the analysis of human-horse dynamic interaction using cardiovascular information exclusively. Specifically, the Information Theoretic Learning (ITL) approach has been applied to a Human-Horse Interaction paradigm, therefore accounting for the nonlinear information of the heart-heart interplay between humans and horses. Heartbeat dynamics was gathered from humans and horses during three experimental conditions: absence of interaction, visual-olfactory interaction, and brooming. Cross Information Potential, Cross Correntropy, and Correntropy Coefficient were computed to quantitatively estimate nonlinear coupling in a group of eleven subjects and one horse...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042440/plant-pathogenesis-related-proteins-of-the-cacao-fungal-pathogen-moniliophthora-perniciosa-differ-in-their-lipid-binding-specificities
#14
Rabih Darwiche, Ola El Atab, Renata Moro Baroni, Paulo J P L Teixeira, Jorge M C Mondego, Gonçalo A G Pereira, Roger Schneiter
Moniliophthora perniciosa is the causative agent of witches' broom disease, which devastates cacao cultures in South America. This pathogenic fungus infects meristematic tissues and derives nutrients from the plant apoplast during an unusually long-lasting biotrophic stage. In order to survive, the fungus produces proteins to suppress the plant immune response. Proteins of the Pathogenesis Related 1 (PR-1)/CAP superfamily have been implicated in fungal virulence and immune suppression. The genome of M. perniciosa encodes eleven homologues of plant PR-1 proteins, designated MpPR-1 proteins, but their precise mode of action is poorly understood...
October 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29038787/comparative-proteomic-analysis-of-paulownia-fortunei-response-to-phytoplasma-infection-with-dimethyl-sulfate-treatment
#15
Zhen Wei, Zhe Wang, Xiaoyu Li, Zhenli Zhao, Minjie Deng, Yanpeng Dong, Xibing Cao, Guoqiang Fan
Paulownia fortunei is a widely cultivated economic forest tree species that is susceptible to infection with phytoplasma, resulting in Paulownia witches' broom (PaWB) disease. Diseased P. fortunei is characterized by stunted growth, witches' broom, shortened internodes, and etiolated and smaller leaves. To understand the molecular mechanism of its pathogenesis, we applied isobaric tags for relative and absolute quantitation (iTRAQ) and liquid chromatography coupled with tandem mass spectrometry approaches to study changes in the proteomes of healthy P...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/29037163/diagnostic-performance-of-various-familial-hypercholesterolaemia-diagnostic-criteria-compared-to-dutch-lipid-clinic-criteria-in-an-asian-population
#16
Suraya Abdul-Razak, Radzi Rahmat, Alicezah Mohd Kasim, Thuhairah Abdul Rahman, Suhaila Muid, Nadzimah Mohd Nasir, Zubin Ibrahim, Sazzli Kasim, Zaliha Ismail, Rohana Abdul Ghani, Abdul Rais Sanusi, Azhari Rosman, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) is a genetic disorder with a high risk of developing premature coronary artery disease that should be diagnosed as early as possible. Several clinical diagnostic criteria for FH are available, with the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding diagnostic performances of the other criteria against the DLCC is scarce. We aimed to examine the diagnostic performance of the Simon-Broom (SB) Register criteria, the US Make Early Diagnosis to Prevent Early Deaths (US MEDPED) and the Japanese FH Management Criteria (JFHMC) compared to the DLCC...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29032794/handbook-on-gender-and-health-edited-by-jasmine-gideon
#17
Reviewed By Dorothy H Broom
No abstract text is available yet for this article.
March 2017: Health Promotion Journal of Australia
https://www.readbyqxmd.com/read/29028457/photocatalytic-degradation-of-p-cresol-using-tio2-zno-hybrid-surface-capped-with-polyaniline
#18
Thabo J Brooms, Benton Otieno, Maurice S Onyango, Aoyi Ochieng
This study evaluated the photocatalytic activity of polyaniline (PANI)-capped titanium dioxide and zinc oxide (TiO2/ZnO) hybrid, for the degradation of P-Cresol. The hybrid was synthesized by precipitating ZnO on the surface of commercial TiO2. An "in situ" chemical oxidative polymerization method was used to prepare the PANI capped hybrid (TiO2/ZnO/PANI). The photocatalysts were characterized by powder X-ray diffraction (XRD), a Brunauer Emmett Teller (BET) analyzer, Fourier-transform infrared (FTIR) and photoluminescence spectroscopies, high resolution-transmission electron microscopy (HR-TEM) and thermogravimetric analysis (TGA)...
October 13, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29028422/enterococcus-faecalis-endophthalmitis-in-children-a-21-year-study
#19
Ekta Rishi, Pukhraj Rishi, Pramod Bhende, Rajiv Raman, Parveen Sen, Pradeep Susvar, Chetan Rao, Lily Therese, Rajshri Hirawat
PURPOSE: To report Enterococcus faecalis endophthalmitis (EFE) in children and its comparison with adults. METHODS: Retrospective study of 19 children up to 18 years age, undergoing vitrectomy for EFE at a referral eye center from January 1995 to December 2015. The results were compared to 18 adults with EFE. RESULTS: The mean age was 7.4 ± 3.06 years. Post-traumatic EFE was seen in 17 (89.4%) children (p < 0.05) versus postoperative EFE seen in 12 (66%) adults...
October 13, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020419/cortical-gaba-in-subjects-at-ultra-high-risk-of-psychosis-relationship-to-negative-prodromal-symptoms
#20
Gemma Modinos, Fatma Simsek, Jamie Horder, Matthijs Bossong, Ilaria Bonoldi, Matilda Azis, Jesus Perez, Matthew Broome, David J Lythgoe, James M Stone, Oliver D Howes, Declan G Murphy, Anthony A Grace, Paul Allen, Philip McGuire
Background: Whilst robust preclinical and postmortem evidence suggests that altered GABAergic function is central to the development of psychosis, little is known about whether it is altered in subjects at ultra-high risk of psychosis, or its relationship to prodromal symptoms. Methods: Twenty-one anti-psychotic naïve UHR individuals and 20 healthy volunteers underwent proton magnetic resonance imaging at 3T. GABA levels were obtained from the medial prefrontal cortex (MPFC) using MEGA-PRESS, and expressed as peak-area ratios relative to the synchronously-acquired creatine signal...
August 19, 2017: International Journal of Neuropsychopharmacology
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