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https://www.readbyqxmd.com/read/27909252/nurses-as-antibiotic-brokers-institutionalized-praxis-in-the-hospital
#1
Alex Broom, Jennifer Broom, Emma Kirby, Graham Scambler
We are likely moving rapidly toward a post-antibiotic era, as a result of escalating antimicrobial resistance, rapidly declining antibiotic production and profligate overuse. Hitherto research has almost exclusively focused on doctors' prescribing, with nurses' roles in antibiotic use remaining virtually invisible. Drawing on interviews with 30 nurses, we focus on nurses as brokers of doctors' antibiotic decisions, nursing capacity to challenge doctors' decisions, and, "back stage" strategies for circumnavigating organizational constraints...
November 30, 2016: Qualitative Health Research
https://www.readbyqxmd.com/read/27908736/cd98-mediated-adhesive-signaling-enables-the-establishment-and-propagation-of-acute-myelogenous-leukemia
#2
Jeevisha Bajaj, Takaaki Konuma, Nikki K Lytle, Hyog Young Kwon, Jailal N Ablack, Joseph M Cantor, David Rizzieri, Charles Chuah, Vivian G Oehler, Elizabeth H Broome, Edward D Ball, Edward H van der Horst, Mark H Ginsberg, Tannishtha Reya
Acute myelogenous leukemia (AML) is an aggressive disease associated with drug resistance and relapse. To improve therapeutic strategies, it is critical to better understand the mechanisms that underlie AML progression. Here we show that the integrin binding glycoprotein CD98 plays a central role in AML. CD98 promotes AML propagation and lethality by driving engagement of leukemia cells with their microenvironment and maintaining leukemic stem cells. Further, delivery of a humanized anti-CD98 antibody blocks growth of patient-derived AML, highlighting the importance of this pathway in human disease...
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27902706/a-qualitative-study-of-medical-oncologists-experiences-of-their-profession-and-workforce-sustainability
#3
Alex Broom, W K Tim Wong, Emma Kirby, David Sibbritt, Deme Karikios, Rosemary Harrup, Zarnie Lwin
BACKGROUND: Medical oncology is a steadily evolving field of medical practice and professional pathway for doctors, offering value, opportunity and challenge to those who chose this medical specialty. This study examines the experiences of a group of Australian medical oncologists, with an emphasis on their professional practice, career experiences, and existing and emerging challenges across career stages. METHODS: In-depth qualitative interviews were conducted with 22 medical oncologists, including advanced trainees, early-career consultants and senior consultants, focusing on: professional values and experiences; career prospects and pathways; and, the nexus of the characteristics of the profession and delivery of care...
2016: PloS One
https://www.readbyqxmd.com/read/27895378/intravesical-foreign-body-tertiary-care-center-experience-from-pakistan
#4
Hussam Uddin Soomro, Imran Jalbani, Nuzhat Faruqui
Foreign body in bladder is relatively uncommon condition with variable presentations. Literature is limited to case reports and small series from region. Therefore, we planned this study to review our experience regarding intravesical foreign body. This retrospective study was conducted at the Aga Khan University Hospital, Karachi, and comprised 14 patients having intravesical foreign bodies from March 1989 to March 2013. Demographics, presentation, mode of insertion, type of foreign body and management were noted...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27889901/a-novel-approach-to-screening-for-familial-hypercholesterolemia-in-a-large-public-venue
#5
Megan Campbell, Jessa Humanki, Heather Zierhut
The primary aim of this study was to test the feasibility of a public health screening program to identify individuals at high risk of familial hypercholesterolemia through a novel screening approach at a large public venue. A finger-prick, non-fasting lipid panel was obtained, and a survey which consisted of 44 open- and close-ended questions divided into four sections: medical and family history of FH, opinions of cascade genetic testing, patient activation, and demographics was completed. A total of 971 participants met criteria and completed a cholesterol screen...
November 26, 2016: Journal of Community Genetics
https://www.readbyqxmd.com/read/27886666/nurse-scientist-or-nursing-scientist-future-considerations-for-the-field
#6
EDITORIAL
Marion E Broome, Kirsten Corazzini
No abstract text is available yet for this article.
November 2016: Nursing Outlook
https://www.readbyqxmd.com/read/27885775/the-coffee-leaf-rust-pathogen-hemileia-vastatrix-one-and-a-half-centuries-around-the-tropics
#7
Pedro Talhinhas, Dora Batista, Inês Diniz, Ana Vieira, Diogo N Silva, Andreia Loureiro, Sílvia Tavares, Ana Paula Pereira, Helena G Azinheira, Leonor Guerra-Guimarães, Vítor Várzea, Maria do Céu Silva
Taxonomy and history: Hemileia vastatrix Berk. and Broome (Basidiomycota, Pucciniales) was described in 1869 in Eastern Africa and Ceylon as the agent of Coffee Leaf Rust and spread to all coffee cultivation areas worldwide. Major disease outbreaks in Asia, Africa and America caused and continue to cause severe yield losses, making this the most important disease of Arabica coffee, a cash crop for many tropical and sub-tropical countries. Life cycle and disease symptoms: Hemileia vastatrix is a hemicyclic fungus with the urediniosporic life cycle as its most important (if not only) source of inoculum...
November 25, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27885148/injury-interiority-and-isolation-in-men-s-suicidality
#8
John L Oliffe, Genevieve Creighton, Steve Robertson, Alex Broom, Emily K Jenkins, John S Ogrodniczuk, Olivier Ferlatte
Men's high suicide rates have been linked to individual risk factors including history of being abused as a child, single marital status, and financial difficulties. While it has also been suggested that the normative influences of hegemonic masculinities are implicated in men's suicide, the gendered experiences of male suicidality are poorly understood. In the current photovoice study, 20 men who previously had suicidal thoughts, plans, and/or attempts were interviewed as a means to better understanding the connections between masculinities and their experiences of suicidality...
November 23, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27879171/detection-and-quantification-of-adulterants-in-milk-powder-using-high-throughput-raman-chemical-imaging-technique
#9
Jianwei Qin, Moon S Kim, Kuanglin Chao, Sagar Dhakal, Hoonsoo Lee, Byoung-Kwan Cho, Changyeun Mo
Milk is a vulnerable target for economically motivated adulteration. In this study, a line-scan high-throughput Raman imaging system was used to authenticate milk powder. A 5 W 785 nm line laser (240 mm long and 1 mm wide) was used as a Raman excitation source. The system was used to acquire hyperspectral Raman images in a wavenumber range of 103-2881 cm(-1) from the skim milk powder mixed with two nitrogen-rich adulterants (i.e., melamine and urea) at eight concentrations (w/w) from 50 to 10,000 ppm. The powdered samples were put in sample holders with a surface area of 150 mm×100 mm and a depth of 2 mm for push-broom image acquisition...
November 23, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27850544/906-determination-of-indication-based-extended-interval-gentamicin-dosing-regimens-for-neonates
#10
Michelle Rychalsky, Meghan Rowcliffe, Jessica Vital-Carona, Laura Broome, Sarah Kelly, Matthew Bizzarro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27826458/factors-influencing-the-incidence-of-severe-complications-in-head-and-neck-free-flap-reconstructions
#11
Martin Broome, Naline Juilland, Yann Litzistorf, Yan Monnier, Kishore Sandu, Philippe Pasche, Peter K Plinkert, Philippe A Federspil, Christian Simon
BACKGROUND: Complications after head and neck free-flap reconstructions are detrimental and prolong hospital stay. In an effort to identify related variables in a tertiary regional head and neck unit, the microvascular reconstruction activity over the last 5 years was captured in a database along with patient-, provider-, and volume-outcome-related parameters. METHODS: Retrospective cohort study (level of evidence 3), a modified Clavien-Dindo classification, was used to assess severe complications...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27825178/ruscus-genus-a-rich-source-of-bioactive-steroidal-saponins
#12
Milena Masullo, Cosimo Pizza, Sonia Piacente
The genus Ruscus (Asparagaceae family) is native to the Mediterranean, Southern and Western Europe and is represented by perennial, rhizomatous, and evergreen shrubs. Among the approximately seven species spread throughout Europe up to Iran, Ruscus aculeatus L. (butcher's broom) is the most widely distributed and appreciated. This review provides an overview of the traditional use of Ruscus spp., the current knowledge of the chemistry of this genus, and the pharmacological studies carried out on Ruscus spp...
November 8, 2016: Planta Medica
https://www.readbyqxmd.com/read/27824938/genome-wide-identification-and-analysis-of-micrornas-involved-in-witches-broom-phytoplasma-response-in-ziziphus-jujuba
#13
Fenjuan Shao, Qian Zhang, Hongwei Liu, Shanfa Lu, Deyou Qiu
MicroRNAs (miRNAs) play an important role in responding to biotic and abiotic stresses in plants. Jujube witches'-broom a phytoplasma disease of Ziziphus jujuba is prevalent in China and is a serious problem to the industry. However, the molecular mechanism of the disease is poorly understood. In this study, genome-wide identification and analysis of microRNAs in response to witches'-broom was performed. A total of 85 conserved miRNA unique sequences belonging to 32 miRNA families and 24 novel miRNA unique sequences, including their complementary miRNA* strands were identified from small RNA libraries derived from a uninfected and witches'-broom infected Z...
2016: PloS One
https://www.readbyqxmd.com/read/27815613/on-chip-intermediate-led-if-based-detection-for-the-control-of-electromigration-in-multichannel-networks
#14
Daniel Sydes, Pablo A Kler, Hans Meyer, Peter Zipfl, Daniel Lutz, Carolin Huhn
Monitoring analytes during the transfer step from the first to the second dimension in multidimensional electrophoretic separations is crucial to determine and control the optimal time point for sample transfer and thus to avoid band broadening or unwanted splitting of the sample band with consequent sample loss. A spatially resolved intermediate on-chip LED-induced fluorescence detection system was successfully implemented for a hybrid capillary-chip glass interface. The setup includes a high-power 455-nm LED prototype as an excitation light source and a linear light fiber array consisting of 23 light fibers with a diameter of 100 μm for spatially resolved fluorescence detection in combination with a push-broom imager for hyperspectral detection...
December 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27809737/a-rapid-assessment-of-the-impact-of-hazard-reduction-burning-around-sydney-may-2016
#15
Richard A Broome, Fay H Johnston, Joshua Horsley, Geoffrey G Morgan
No abstract text is available yet for this article.
November 7, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27791136/probing-the-free-energy-landscapes-of-als-disease-mutants-of-sod1-by-nmr-spectroscopy
#16
Ashok Sekhar, Jessica A O Rumfeldt, Helen R Broom, Colleen M Doyle, Ryan E Sobering, Elizabeth M Meiering, Lewis E Kay
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that, in some cases, has been linked with mutations to the antioxidant metalloenzyme superoxide dismutase (SOD1). Although the mature form of this enzyme is highly stable and resistant to aggregation, the most immature form, lacking metal and a stabilizing intrasubunit disulfide bond, apoSOD1(2SH), is dynamic and hypothesized to be a major cause of toxicity in vivo. Previous solution NMR studies of wild-type apoSOD1(2SH) have shown that the ground state interconverts with a series of sparsely populated and transiently formed conformers, some of which have aberrant nonnative structures...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779328/does-australia-s-health-policy-environment-create-unintended-outcomes-for-birthing-women
#17
Amie Steel, Jon Adams, Jane Frawley, Jon Wardle, Alex Broom, Mary Sidebotham, David Sibbritt
No abstract text is available yet for this article.
December 2016: Birth
https://www.readbyqxmd.com/read/27773297/zinc-silicates-with-tunable-morphology-by-surfactant-assisted-sonochemical-route-suitable-for-nuv-excitable-white-light-emitting-diodes
#18
R B Basavaraj, H Nagabhushana, B Daruka Prasad, G R Vijayakumar
The cationic surfactants assisted ultrasound route was used to prepare Dy(3+) doped Zn2SiO4 nanophosphors. The final products were characterized by powder X-ray diffraction (PXRD), ultraviolet visible spectroscopy, scanning electron microscopy, transmission electron microscopy and photoluminescence. Orthorhombic phase of Zn2SiO4:Dy(3+) (JCPDS card No. 35-1485) was confirmed from PXRD. It was evident that the morphology of spherical and broom like structures were obtained with epigallocatechin gallate (EGCG) and cetyltrimethylammonium bromide (CTAB) surfactants respectively...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27769147/effects-of-a-12-week-aerobic-exercise-intervention-on-eating-behaviour-food-cravings-and-7-day-energy-intake-and-energy-expenditure-in-inactive-men
#19
Joel Rocha, Jenny Paxman, Caroline Dalton, Edward Winter, David R Broom
This study examined effects of 12 weeks of moderate-intensity aerobic exercise on eating behaviour, food cravings, and weekly energy intake and expenditure in inactive men. Eleven healthy men (mean ± SD: age, 26 ± 5 years; body mass index, 24.6 ± 3.8 kg·m(-2); maximum oxygen uptake, 43.1 ± 7.4 mL·kg(-1)·min(-1)) completed the 12-week supervised exercise programme. Body composition, health markers (e.g., blood pressure), eating behaviour, food cravings, and weekly energy intake and expenditure were assessed before and after the exercise intervention...
July 15, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27757373/population-genetic-analysis-reveals-a-low-level-of-genetic-diversity-of-candidatus-phytoplasma-aurantifolia-causing-witches-broom-disease-in-lime
#20
Shaikha Y Al-Abadi, Abdullah M Al-Sadi, Matthew Dickinson, Mohammed S Al-Hammadi, Rashid Al-Shariqi, Rashid A Al-Yahyai, Elham A Kazerooni, Assunta Bertaccini
Witches' broom disease of lime (WBDL) is a serious phytoplasma disease of acid lime in Oman, the UAE and Iran. Despite efforts to study it, no systemic study attempted to characterize the relationship among the associated phytoplasma, 'Candidatus Phytoplasma aurantifolia', from the three countries. This study utilized sequences of the 16S rRNA, imp and secA genes to characterize 57 strains collected from Oman (38), the UAE (9) and Iran (10). Phylogenetic analysis based on the 16S rRNA gene showed that the 57 strains shared 98...
2016: SpringerPlus
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