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https://www.readbyqxmd.com/read/28207982/understanding-ethical-issues-of-research-participation-from-the-perspective-of-participating-children-and-adolescents-a-systematic-review
#1
Stacey Crane, Marion E Broome
BACKGROUND: The past 20 years have seen distinct shifts in the way the participation of children and adolescents in research is viewed. This has been emphasized by the growing pediatric research enterprise. Additional information on children's and adolescents' experiences during research participation is needed to better inform researchers on the ethical conduct of research with this vulnerable population. AIMS: The objective of this analysis was to examine ethical issues in research with children and adolescents from their perspective as participants, including: assent, parental consent, risk perception, impact of research participation, and incentives...
February 16, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28199881/the-influence-of-early-degenerative-changes-on-the-vulnerability-of-articular-cartilage-to-impact-induced-injury
#2
Joshua Workman, Ashvin Thambyah, Neil Broom
BACKGROUND: Recently, the structural changes in a bovine model of early degeneration were validated by our research group to be analogous to that in early human osteoarthritis. The hypothesis of this study was that the structural changes associated with increasing levels of degeneration would lead to higher levels of tissue damage in response to impact induced injury. METHODS: A total of forty bovine patellae were obtained for this study. Cartilage-on-bone samples were extracted from the distal lateral quarter, a region known to be affected by varying levels of degeneration...
January 4, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28193572/systematic-review-of-early-and-long-term-outcome-of-liver-resection-for-metastatic-breast-cancer-is-there-a-survival-benefit
#3
REVIEW
Tae Gon Yoo, Isaac Cranshaw, Reuben Broom, Sanjay Pandanaboyana, Adam Bartlett
BACKGROUND: Isolated liver metastases occur rarely in patients with metastatic breast cancer. The success of liver resection (LR) for other metastatic disease has led centres to explore the option of LR for patients with isolated breast cancer liver metastases (BCLM). A number of small series have been published in the literature, however the evidence is conflicting. This study aimed to systematically review the literature to determine the perioperative outcome and survival of patients undergoing LR for BCLM...
February 10, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28169035/integration-of-parent-and-nurse-perspectives-of-communication-to-plan-care-for-technology-dependent-children-the-theory-of-shared-communication
#4
Barbara K Giambra, Marion E Broome, Teresa Sabourin, Janice Buelow, Deborah Stiffler
PURPOSE: The purpose of this qualitative research study was to expand our understanding of the process of communication between parents of hospitalized technology dependent children and their nurses originally detailed in the Theory of Shared Communication (TSC). DESIGN AND METHODS: This grounded theory study was conducted with five parents of technology dependent children hospitalized in a large Midwestern children's hospital and nine nurses who care for technology dependent children admitted to the same hospital during July and August 2013...
February 3, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28164783/shaping-the-rn-workforce-for-primary-care
#5
EDITORIAL
Marion E Broome
No abstract text is available yet for this article.
January 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28160724/exploring-the-relationships-between-protein-sequence-structure-and-solubility
#6
REVIEW
Kyle Trainor, Aron Broom, Elizabeth M Meiering
Aggregation can be thought of as a form of protein folding in which intermolecular associations lead to the formation of large, insoluble assemblies. Various types of aggregates can be differentiated by their internal structures and gross morphologies (e.g., fibrillar or amorphous), and the ability to accurately predict the likelihood of their formation by a given polypeptide is of great practical utility in the fields of biology (including the study of disease), biotechnology, and biomaterials research. Here we review aggregation/solubility prediction methods and selected applications thereof...
February 1, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28159021/ebola-outbreak-preparedness-planning-a-qualitative-study-of-clinicians-experiences
#7
J Broom, A Broom, V Bowden
OBJECTIVES: The 2014-15 Ebola outbreak in West Africa highlighted the challenges many hospitals face when preparing for the potential emergence of highly contagious diseases. This study examined the experiences of frontline health care professionals in an Australian hospital during the outbreak, with a focus on participant views on information, training and preparedness, to inform future outbreak preparedness planning. STUDY DESIGN: Semi-structured interviews were conducted with 21 healthcare professionals involved in Ebola preparedness planning, at a hospital in Australia...
February 2017: Public Health
https://www.readbyqxmd.com/read/28150209/fluorescence-and-bioluminescence-imaging-of-orthotopic-brain-tumors-in-mice
#8
Emilie McKinnon, Alfred Moore, Suraj Dixit, Yun Zhu, Ann-Marie Broome
Optical imaging strategies, such as fluorescence and bioluminescence imaging, are non-invasive, in vivo whole body imaging techniques utilized to study cancer. Optical imaging is widely used in preclinical work because of its ease of use and cost-friendliness. It also provides the opportunity to study animals and biological responses longitudinally over time. Important considerations include depth of tissue penetration, photon scattering, absorption and the choice of light emitting probe, all of which affect the resolution (image quality and data information) and the signal to noise ratio of the image...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28139858/geographic-and-socioeconomic-factors-in-patients-with-malignant-pleural-mesothelioma-in-new-south-wales-and-their-impact-upon-clinical-outcomes
#9
Anthony Linton, Matthew Soeberg, Richard Broome, Steven Kao, Nico van Zandwijk
BACKGROUND AND OBJECTIVE: Whilst the impact of clinicopathological factors on the prognosis of malignant pleural mesothelioma (MPM) is well understood, socioeconomic and geographic factors have received less attention. We analysed the relationship between geographic and socioeconomic factors upon survival and treatment provision in a large series of patients with MPM. METHODS: We assessed MPM patients awarded compensation between 2002 and 2009 with additional MPM incidence data from the New South Wales (NSW) Cancer Registry...
January 31, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28115346/targeting-alpha-toxin-to-mitigate-its-lethal-toxicity-in-ferret-and-rabbit-models-of-staphylococcus-aureus-necrotizing-pneumonia
#10
Binh An Diep, Jamese J Hillard, Vien T M Le, Christine Tkaczyk, Hoan N Le, Vuvi G Tran, Renee L Rao, Etyene Castro Dip, Eliane P Pereira-Franchi, Paulyn Cha, Scott Jacobson, Rosemary Broome, Lily I Cheng, William Weiss, Laszlo Prokai, Vien Nguyen, C Ken Stover, Bret R Sellman
The role broad spectrum antibiotics play in the spread of antimicrobial resistance, coupled with their effect on the healthy microbiome have led to advances in pathogen specific approaches for the prevention or treatment of serious bacterial infections. One approach in clinical testing is passive immunization with a monoclonal antibody (mAb) targeting alpha toxin for the prevention or treatment of Staphylococcus aureus pneumonia. Passive immunization with the human anti-alpha toxin mAb, MEDI4893* has been shown to improve disease outcome in murine S...
January 23, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28114261/refinement-of-a-conceptual-model-for-adolescent-readiness-to-engage-in-end-of-life-discussions
#11
Cynthia J Bell, Gregory D Zimet, Pamela S Hinds, Marion E Broome, Anna M McDaniel, Rose M Mays, Victoria L Champion
BACKGROUND: Adolescents living with incurable cancer require ongoing support to process grief, emotions, and information as disease progresses including treatment options (phase 1 clinical trials and/or hospice/palliative care). Little is known about how adolescents become ready for such discussions. OBJECTIVE: The purpose of this study was to explore the process of adolescent readiness for end-of-life preparedness discussions, generating a theoretical understanding for guiding clinical conversations when curative options are limited...
January 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28087366/a-program-to-prevent-burnout-depression-and-anxiety-in-first-year-pediatric-residents
#12
Stuart Slavin, Mindy Shoss, Matthew A Broom
No abstract text is available yet for this article.
January 10, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28078778/texting-preferences-in-a-paediatric-residency
#13
Lauren Draper, Cadence Kuklinski, Amy Ladley, Greg Adamson, Matthew Broom
PURPOSE: Text messaging is ubiquitous among residents, but remains an underused educational tool. Though feasibility has been demonstrated, evidence of its ability to improve standardised test scores and provide insight on resident texting preferences is lacking. The authors set out to evaluate: (1) satisfaction with a hybrid question-and-answer (Q&A) texting format; and (2) pre-/post-paediatric in-training exam (ITE) performance. METHODS: A prospective study with paediatrics and internal medicine-paediatrics residents...
January 12, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/28073794/socioeconomic-remoteness-and-sex-differences-in-life-expectancy-in-new-south-wales-australia-2001-2012-a-population-based-study
#14
Alexandre S Stephens, Leena Gupta, Sarah Thackway, Richard A Broome
OBJECTIVES: Despite being one of the healthiest countries in the world, Australia displays substantial mortality differentials by socioeconomic disadvantage, remoteness and sex. In this study, we examined how these mortality differentials translated to differences in life expectancy between 2001 and 2012. DESIGN AND SETTING: Population-based study using mortality and estimated residential population data from Australia's largest state, New South Wales (NSW), between 2001 and 2012...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28038923/charles-bonnet-syndrome-in-a-child-with-congenital-glaucoma
#15
E Santos-Bueso, M Serrador-García, F Sáenz-Francés, C Méndez-Hernández, L Morales-Fernández, J M Martínez-de-la-Casa, J García-Feijoo, J Porta-Etessam
CASE REPORT: The case is presented of a 12 year-old boy with congenital glaucoma and low visual acuity diagnosed with Charles Bonnet syndrome. This consisted of the acute onset of complex, repetitive, persistent, and with visual hallucinations (people, brooms and coffeemakers) of self-limited evolution without treatment. The patient was diagnosed with congenital glaucoma at 3 years of age, and subjected to a trabeculectomy in right eye, and trabeculectomy and keratoplasty in his left eye...
December 27, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28003774/effectiveness-of-the-multidimensional-ergonomic-intervention-model-to-reduce-musculoskeletal-discomfort-among-street-sweepers-in-chiang-rai-province-thailand
#16
Kanjanar Pintakham, Wattasit Siriwong
The aim of this study was to evaluate the effectiveness of multidimensional ergonomic intervention (MEI) model to reduce musculoskeletal discomfort (MSD) among street sweepers. A quasi-experimental study was conducted in Chiang Rai Province. The MEI model was designed on the basis of four core components: cognitive behavior therapy, ergonomic education training, stretching exercise, and the foam sleeve broom handle grip. Seventy-five street sweepers volunteered for the screening process on MSD of having level score ≥4 by physiotherapist...
2016: Risk Management and Healthcare Policy
https://www.readbyqxmd.com/read/27999089/acute-effect-of-exercise-intensity-and-duration-on-acylated-ghrelin-and-hunger-in-men
#17
David R Broom, Masashi Miyashita, Lucy K Wasse, Richard Pulsford, James A King, Alice E Thackray, David J Stensel
Acute exercise transiently suppresses the orexigenic gut hormone acylated ghrelin, but the extent to which exercise intensity and duration determine this response is not fully understood. The effects of manipulating exercise intensity and duration on acylated ghrelin concentrations and hunger were examined in two experiments. In experiment one, nine healthy males completed three, 4-h conditions (control, moderate-intensity running (MOD) and vigorous-intensity running (VIG)), with an energy expenditure of ~2...
March 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27997761/the-enemy-within-phloem-limited-pathogens
#18
REVIEW
Claire Bendix, Jennifer D Lewis
The growing impact of phloem-limited pathogens on high value crops has renewed interest in understanding how they cause disease. Although these pathogens cause substantial crop losses, many are poorly characterized. In this review, we present examples of phloem-limited pathogens that include intracellular bacteria with and without cell walls, and viruses. Phloem-limited pathogens have small genomes and lack many genes required for core metabolic processes, which is in part an adaptation to the unique phloem environment...
December 20, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/27994988/teaching-near-and-far-broome-western-australia
#19
EDITORIAL
Christina Herceg, Tia Renouf
Broome is a remote coastal town in Western Australia. As a general practitioner working in Broome, I have been involved in the education of general practice trainee registrars both locally and remotely, as a supervisor with two different training programs.
November 9, 2016: Curēus
https://www.readbyqxmd.com/read/27940417/the-right-to-medicalization-invited-commentary-on-karsoho-et%C3%A2-al-2016
#20
Alex Broom
No abstract text is available yet for this article.
January 2017: Social Science & Medicine
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