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Shaikha Y Al-Abadi, Abdullah M Al-Sadi, Matthew Dickinson, Mohammed S Al-Hammadi, Rashid Al-Shariqi, Rashid A Al-Yahyai, Elham A Kazerooni, Assunta Bertaccini
Witches' broom disease of lime (WBDL) is a serious phytoplasma disease of acid lime in Oman, the UAE and Iran. Despite efforts to study it, no systemic study attempted to characterize the relationship among the associated phytoplasma, 'Candidatus Phytoplasma aurantifolia', from the three countries. This study utilized sequences of the 16S rRNA, imp and secA genes to characterize 57 strains collected from Oman (38), the UAE (9) and Iran (10). Phylogenetic analysis based on the 16S rRNA gene showed that the 57 strains shared 98...
2016: SpringerPlus
Constantin Tuleasca, Martin Broome, Pascal J Mosimann, Luis Schiappacasse, Michele Zeverino, Antoine Dorenlot, Jérôme Champoudry, Jean Régis, Marc Levivier
BACKGROUND: The purpose of our report is to describe an innovative system used for mandibular immobilization during Gamma Knife surgery (GKS) procedures. It is based on an approach originally developed in Marseille in extracranial lesions, close to or involving the mandible, which may imply a certain degree of movement during the therapeutic image acquisitions and/or GKS treatment. METHODS: The maxillofacial surgeon applied bone titanium self-tapping monocortical screws (4; 2 mm diameter, 10 mm length) between roots of the teeth in the fixed gingiva (upper and lower maxillae) the day before GKS (local anesthesia, 5-10 min time)...
October 11, 2016: Stereotactic and Functional Neurosurgery
Rachel Upthegrove, Jonathan Ives, Matthew R Broome, Kimberly Caldwell, Stephen J Wood, Femi Oyebode
BACKGROUND: In dimensional understanding of psychosis, auditory verbal hallucinations (AVH) are unitary phenomena present on a continuum from non-clinical voice hearing to severe mental illness. There is mixed evidence for this approach and a relative absence of research into subjective experience of AVH in early psychosis. AIMS: To conduct primary research into the nature of subjective experience of AVH in first-episode psychosis. METHOD: A phenomenological study using diary and photo-elicitation qualitative techniques investigating the subjective experience of AVH in 25 young people with first-episode psychosis...
January 2016: BJPsych Open
A Roome, L Hill, V Al-Feghali, C G Murnock, J A Goodsell, R Spathis, R M Garruto
There is a public perception that the white-tailed deer Odocoileus virginianus (Artiodactyla: Cervidae) is the main reservoir supporting the maintenance and spread of the causative agent of Lyme disease, Borrelia burgdorferi. This study examines the pathogen prevalence rate of Borrelia in adult Ixodes scapularis (Ixodida: Ixodidae), the black-legged tick, collected from white-tailed deer and compares it with pathogen prevalence rates in adult ticks gathered by dragging vegetation in two contiguous counties west of the Hudson Valley in upstate New York...
October 4, 2016: Medical and Veterinary Entomology
Irina Falkenberg, Isabel Valli, Marie Raffin, Matthew R Broome, Paolo Fusar-Poli, Pall Matthiasson, Marco Picchioni, Philip McGuire
BACKGROUND: Clinical outcomes in people identified as at ultra-high risk (UHR) for psychosis are remarkably heterogeneous, and are difficult to predict on the basis of the presenting clinical features. Individuals at UHR are at risk of poor functional outcome regardless of development of psychotic disorder. The aim of the present study was to assess whether there is a relationship between functional neuroimaging measures at presentation and functional outcome as measured by the GAF three years after scanning...
September 29, 2016: Schizophrenia Research
A Broom, A F Gibson, J Broom, E Kirby, T Yarwood, J J Post
BACKGROUND: Antibiotic optimization in hospitals is an increasingly critical priority in the context of proliferating resistance. Despite the emphasis on doctors, optimizing antibiotic use within hospitals requires an understanding of how different stakeholders, including non-prescribers, influence practice and practice change. AIM: This study was designed to understand Australian hospital managers' perspectives on antimicrobial resistance, managing antibiotic governance, and negotiating clinical vis-à-vis managerial priorities...
August 31, 2016: Journal of Hospital Infection
Robert Vogel, Frank A W Coumans, Raluca G Maltesen, Anita N Böing, Katherine E Bonnington, Marike L Broekman, Murray F Broom, Edit I Buzás, Gunna Christiansen, Najat Hajji, Søren R Kristensen, Meta J Kuehn, Sigrid M Lund, Sybren L N Maas, Rienk Nieuwland, Xabier Osteikoetxea, Rosalie Schnoor, Benjamin J Scicluna, Mitch Shambrook, Jeroen de Vrij, Stephen I Mann, Andrew F Hill, Shona Pedersen
BACKGROUND: Understanding the pathogenic role of extracellular vesicles (EVs) in disease and their potential diagnostic and therapeutic utility is extremely reliant on in-depth quantification, measurement and identification of EV sub-populations. Quantification of EVs has presented several challenges, predominantly due to the small size of vesicles such as exosomes and the availability of various technologies to measure nanosized particles, each technology having its own limitations. MATERIALS AND METHODS: A standardized methodology to measure the concentration of extracellular vesicles (EVs) has been developed and tested...
2016: Journal of Extracellular Vesicles
Zahid S Ahmad, Rolf L Andersen, Lars H Andersen, Emily C O'Brien, Iris Kindt, Peter Shrader, Chandna Vasandani, Connie B Newman, Emil M deGoma, Seth J Baum, Linda C Hemphill, Lisa C Hudgins, Catherine D Ahmed, Iftikhar J Kullo, Samuel S Gidding, Danielle Duffy, William Neal, Katherine Wilemon, Matthew T Roe, Daniel J Rader, Christie M Ballantyne, MacRae F Linton, P Barton Duell, Michael D Shapiro, Patrick M Moriarty, Joshua W Knowles
BACKGROUND: In the US familial hypercholesterolemia (FH), patients are underidentified, despite an estimated prevalence of 1:200 to 1:500. Criteria to identify FH patients include Simon Broome, Dutch Lipid Clinic Network (DLCN), or Make Early Diagnosis to Prevent Early Deaths (MEDPED). The use of these criteria in US clinical practices remains unclear. OBJECTIVE: To characterize the FH diagnostic criteria applied by US lipid specialists participating in the FH Foundation's CASCADE FH (CAscade SCreening for Awareness and DEtection of Familial Hypercholesterolemia) patient registry...
September 2016: Journal of Clinical Lipidology
Martin Bødtker Mortensen, Imra Kulenovic, Ib Christian Klausen, Erling Falk
BACKGROUND: Familial hypercholesterolemia (FH) is a hereditary disease carrying a substantial lifetime risk of coronary heart disease. OBJECTIVE: To assess the prevalence of FH and its impact on age at presentation among unselected patients with first myocardial infarction (MI). METHODS: In a multi-center cross sectional study, we identified 1381 unselected patients presenting with a first MI between 2010 and 2012. Clinical FH was assessed using both the Dutch Lipid Clinic Network (DLCN) criteria and the Simon Broome criteria...
September 2016: Journal of Clinical Lipidology
Loïc Chaumont, Valéry Malécot, Richard Pymar, Chaker Sbai
Data obtained from ISSR amplification may readily be extracted but only allows us to know, for each gene, if a specific allele is present or not. From this partial information we provide a probabilistic method to reconstruct the pedigree corresponding to some families of diploid cultivars. This method consists in determining for each individual what is the most likely couple of parent pair amongst all older individuals, according to some probability measure. The construction of this measure bears on the fact that the probability to observe the specific alleles in the child, given the status of the parents does not depend on the generation and is the same for each gene...
September 24, 2016: Journal of Theoretical Biology
Farzad Mostashari, Travis Broome
In this article, we seek to provide the first detailed description of a Medicare Shared Savings Program (MSSP) accountable care organization (ACO)'s actions and results to help increase understanding of the challenges and opportunities facing ACOs, and in particular, those comprised of a network of independent practices. Whether ACOs have been successful in delivering value has been the subject of much debate and speculation. What has been missing from this discussion is a look at the program from the frontlines and those who are launching and running MSSP ACOs...
September 2016: American Journal of Managed Care
David Sibbritt, Romy Lauche, Tobias Sundberg, Wenbo Peng, Craig Moore, Alex Broom, Emma Kirby, Jon Adams
BACKGROUND: Back pain is a common, disabling and costly disorder for which patients often consult with a wide range of health practitioners. Unfortunately, no research to date has directly examined the association between the severity of back pain and back pain sufferers' choice of whom and in what order to consult different health practitioners. METHODS: This is a sub-study of the large nationally representative Australian Longitudinal Study on Women's Health (ALSWH)...
2016: BMC Musculoskeletal Disorders
S H Ho, P Speldewinde, A Cook
A Bayesian Belief Network (BBN) for assessing the potential risk of dengue virus emergence and distribution in Western Australia (WA) is presented and used to identify possible hotspots of dengue outbreaks in summer and winter. The model assesses the probabilities of two kinds of events which must take place before an outbreak can occur: (1) introduction of the virus and mosquito vectors to places where human population densities are high; and (2) vector population growth rates as influenced by climatic factors...
September 13, 2016: Epidemiology and Infection
Steven Marwaha, Andrew Thompson, Rachel Upthegrove, Matthew R Broome
Early intervention for psychosis (EIP) is a model of service delivery that aims to support young people with first-episode psychosis by providing the best available treatments, supporting recovery and preventing relapse. In this editorial, we review the evidence for EIP, how the model has developed since its inclusion in the NHS policy implementation guideline for mental health in 2001, challenges and areas of ongoing debate, and future development.
September 2016: British Journal of Psychiatry: the Journal of Mental Science
Laura Jayne Broome, Ceri Elisabeth Battle, Matthew Lawrence, Phillip Adrian Evans, Michael Stuart Dennis
BACKGROUND: Patients treated with thrombolytic therapy within 4.5 hours after stroke onset appear to have improved survival and functional outcomes. Poststroke cognitive impairment is associated with reduced quality of life and survival and needs to be reviewed in consideration of the administration of thrombolysis. This review aims to systematically evaluate literature exploring the effect of thrombolysis for ischemic stroke on cognition. METHODS: An electronic search was conducted to identify articles and gray literature applying broad Medical Subject Heading terms...
August 25, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Michael J Overman, Van Morris, Helen Moinova, Ganiraju Manyam, Joe Ensor, Michael S Lee, Cathy Eng, Bryan Kee, David Fogelman, Rachna T Shroff, Thomas LaFramboise, Thibault Mazard, Tian Feng, Stanley Hamilton, Bradley Broom, James Lutterbaugh, Jean-Pierre Issa, Sanford D Markowitz, Scott Kopetz
PURPOSE: Hypermethylation of promoter CpG islands (CIMP) has been strongly implicated in chemotherapy resistance and is implicated in the pathogenesis of a subset of colorectal cancers (CRCs) termed CIMP-high. EXPERIMENTAL DESIGN: This phase I/II study in CRC (phase II portion restricted to CIMP-high CRC), treated fluoropyrimidine/oxaliplatin refractory patients with azacitidine (75 mg/m2/day subcutaneously D1-5) and CAPOX (capecitibine and oxaliplatin) every three weeks...
August 16, 2016: Oncotarget
Alexander Broom, Mathew D Schur, Alexandre Arkader, John Flynn, Alex Gornitzky, Paul D Choi
PURPOSE: To study the cause, diagnosis, treatment and outcome of acute compartment syndrome in infants and toddlers aged <3 years. METHODS: Fifteen patients aged <3 years with acute compartment syndrome were identified from two large pediatric trauma centers over a fifteen-year period. All children underwent fasciotomy. The mechanism of injury, time of injury, time to diagnosis, compartment pressures, time to fasciotomy, and outcome at the time of the latest follow-up were recorded...
October 2016: Journal of Children's Orthopaedics
Kezia Batisai
UNLABELLED: This article frames the intersections of medicine and humanities as intrinsic to understanding the practice of health care in Africa. Central to this manuscript, which draws on empirical findings on the interplay between HIV and AIDS and alternative medicine in Zimbabwe is the realisation that very limited research has been undertaken to examine 'HIV/AIDS patient behaviour' with respect to choice of therapy on the continent [Bene, M. & Darkoh, M. B. K. (2014). The Constraints of Antiretroviral Uptake in Rural Areas: The Case of Thamaga and Surrounding Villages, Botswana...
December 2016: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
Parth Shah, Charles J Glueck, Vybhav Jetty, Naila Goldenberg, Matan Rothschild, Rashid Riaz, Gregory Duhon, Ping Wang
BACKGROUND: PCSK9 inhibitor therapy has been approved by the FDA as an adjunct to diet-maximal tolerated cholesterol lowering drug therapy for adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) with suboptimal LDL cholesterol (LDLC) lowering despite maximal diet-drug therapy. With an estimated ~24million of US hypercholesterolemic patients potentially eligible for PCSK9 inhibitors, costing ~ $14,300/patient/year, it is important to assess health-care savings arising from PCSK9 inhibitors vs ASCVD cost...
2016: Lipids in Health and Disease
Samantha A Rodrigues, Ashvin Thambyah, Neil D Broom
The annulus-endplate anchorage system plays a vital role in structurally linking the compliant disc to its adjacent much more rigid vertebrae. Past literature has identified the endplate as a region of weakness, not just in the mature spine but also in the immature spine. The aim of this structural study was to investigate in detail the morphological changes associated with annulus-endplate integration through different stages of maturity. Ovine lumbar motion segments were collected from two immature age groups: (i) newborn and (ii) spring lamb (roughly 3 months old); these were compared with a third group of previously analysed mature ewe samples (3-5 years)...
August 18, 2016: Journal of Anatomy
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