keyword
https://read.qxmd.com/read/36237915/comprehensive-care-for-people-living-with-heart-failure-and-chronic-obstructive-pulmonary-disease-integration-of-palliative-care-with-disease-specific-care-from-guidelines-to-practice
#21
REVIEW
Anna Kowalczys, Michał Bohdan, Alina Wilkowska, Iga Pawłowska, Leszek Pawłowski, Piotr Janowiak, Ewa Jassem, Małgorzata Lelonek, Marcin Gruchała, Piotr Sobański
Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are the leading global epidemiological, clinical, social, and economic burden. Due to similar risk factors and overlapping pathophysiological pathways, the coexistence of these two diseases is common. People with severe COPD and advanced chronic HF (CHF) develop similar symptoms that aggravate if evoking mechanisms overlap. The coexistence of COPD and CHF limits the quality of life (QoL) and worsens symptom burden and mortality, more than if only one of them is present...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36178014/preparation-and-characterization-of-flexible-furosemide-loaded-biodegradable-microneedles-for-intradermal-drug-delivery
#22
JOURNAL ARTICLE
Arsalan Abu-Much, Raya Darawshi, Hala Dawud, Haytam Kasem, Aiman Abu Ammar
Transdermal drug delivery systems are a useful and minimally invasive alternative to other drug administration routes. Biodegradable polymeric microneedles (MNs) are widely used in controlled-release drug delivery due to their tunable properties and ease of patient self-administration. Polylactic- co -glycolic acid (PLGA) is often used for sustained drug release owing to special intrinsic properties including biocompatibility and biodegradability, which offer excellent applicability in preparing MNs. Congestive heart failure (CHF) is characterized by fluid overload during acute exacerbation, necessitating frequent patient hospitalization for continuous intravenous (i...
September 30, 2022: Biomaterials Science
https://read.qxmd.com/read/36118136/quantitative-and-qualitative-research-on-management-strategies-for-dyspnoea-in-elderly-patients-with-coronary-heart-disease-complicated-with-chronic-heart-failure
#23
JOURNAL ARTICLE
Ya-Nan Niu, Rui Li, Pei Zhao, Piao He, Yan-Ling Li, Yun Wang
Objective: To investigate the most effective strategies for the management of dyspnoea in elderly patients with coronary atherosclerotic heart disease (CHD) complicated with chronic heart failure (CHF). Methods: The best management plans for dyspnoea were evaluated using quantitative and qualitative research techniques for a total of 120 senior patients with CHD complicated with CHF. A self-made questionnaire on dyspnoea management strategies served as the survey instrument for the cross-sectional quantitative investigation...
2022: Journal of Multidisciplinary Healthcare
https://read.qxmd.com/read/36110480/case-report-highlighting-cardiovascular-effects-of-concomitant-use-of-methamphetamine-and-marijuana
#24
Sophia Fontana, Ladan Panahi, George Udeani, Salim Surani, Deepa Desai
We present the case of a 51-year-old male admitted for cardiovascular complications in the face of concomitant chronic methamphetamine and cannabis use. Upon further assessment, the patient exhibited cardiotoxicity, including acute to chronic congestive heart failure (CHF) exacerbation, hypercoagulable state, and electrolyte abnormalities. Cardiotoxicity secondary to chronic methamphetamine use has been established. However, marijuana's cardiovascular effects have not been well established. Even less information exists about the simultaneous use of methamphetamine and cannabis...
August 2022: Curēus
https://read.qxmd.com/read/36035044/a-case-report-on-an-underappreciated-cause-of-heart-failure-chronic-viral-myocarditis
#25
Sandra K Rabat, Usman Manzoor, Naeem Ijaz, Mark M Aloysius
A 64-year-old male with a history of congestive heart failure (CHF), coronary artery disease status post two stents in 2014, hypertension, and chronic kidney disease (CKD) stage III, was admitted for acute exacerbation of CHF. Treatment started with blood pressure control and high-dose diuretics. While the patient's volume status improved, his clinical status declined, and he required a dobutamine infusion. Cardiac catheterization revealed nonischemic cardiomyopathy. He was ultimately found to have myocarditis secondary to chronic Coxsackie B infection...
July 2022: Curēus
https://read.qxmd.com/read/35869917/acute-decompensated-heart-failure-a-pharmacologic-review
#26
JOURNAL ARTICLE
Josmi Joseph, Aeman Choudhury, Sean P Kane
Chronic heart failure (CHF) is a growing disease in the United States. Exacerbations of CHF can lead to acute decompensated heart failure (ADHF) and hospitalizations. Nurses play a key role in the treatment of ADHF as they administer medications, monitor patients' response to therapy, and can prompt providers to alter therapy if therapeutic outcomes are not being achieved. Nurses also play a vital role in discharge education for patients who are hospitalized for ADHF, as they can counsel patients on ways to reduce further hospitalizations...
July 2022: Orthopaedic Nursing
https://read.qxmd.com/read/35812616/the-obesity-paradox-in-chronic-heart-disease-and-chronic-obstructive-pulmonary-disease
#27
REVIEW
Suganya Giri Ravindran, Debistuti Saha, Iffat Iqbal, Sharan Jhaveri, Chaithanya Avanthika, Mridula Sree Naagendran, Lakshmi Deepak Bethineedi, Tony Santhosh
Obesity in recent years has become an epidemic. A high body mass index (BMI) is one of today's most crucial population health indicators. BMI does not directly quantify body fat but correlates well with easier body fat measurements. Like smoking, obesity impacts multiple organ systems and is a major modifiable risk factor for countless diseases. Despite this, reports have emerged that obesity positively impacts the prognosis of patients with chronic illnesses such as chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD), a phenomenon known as the Obesity Paradox...
June 2022: Curēus
https://read.qxmd.com/read/35735822/serum-and-vascular-stiffness-biomarkers-associated-with-the-severity-of-degenerative-aortic-valve-stenosis-and-cardiovascular-outcomes
#28
JOURNAL ARTICLE
Jakub Baran, Łukasz Niewiara, Jakub Podolec, Mateusz Siedliński, Ewelina Józefczuk, Anna Bernacik, Rafał Badacz, Tadeusz Przewłocki, Piotr Pieniążek, Krzysztof Żmudka, Jacek Legutko, Anna Kabłak-Ziembicka
BACKGROUND: Although degenerative aortic valve stenosis (DAS) is the most prevalent growth-up congestive heart valve disease, still little known about relationships between DAS severity, vascular stiffness (VS), echocardiographic parameters, and serum biomarkers in patients undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR). The objective of this study was to identify biomarkers associated with DAS severity, and those that are associated with cardiovascular death (CVD) and episodes of chronic heart failure (CHF) exacerbation...
June 17, 2022: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/35556949/role-of-cardiosphere-derived-cell-extracellular-vesicles-cdc-evs-in-modulating-ccr2-mediated-pro-inflammatory-signaling-following-cardiac-injury
#29
JOURNAL ARTICLE
Rohan Pandey, Kyle I Mentkowski, Paul Schiffmacher, Touba Tarvirdizadeh, Jennifer K Lang
BACKGROUND: Following myocardial injury, CCL2 (a cytokine released by the injured cardiac tissue) recruits CCR2+ monocytes to the site of injury to begin the repair process. Heightened CCL2 levels, however, over-activate the CCR2+ mediated pro-inflammatory response which in turn leads to poor cardiac healing and gives rise to downstream complications like congestive heart failure (CHF) and arrhythmias. Cardiosphere-derived cell extracellular vesicles (CDC-EVs) have been shown to down regulate this CCL2-mediated inflammatory response by decreasing CCR2 expression on monocytes in healthy patients...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/34991097/a-resident-driven-quality-improvement-project-to-increase-primary-care-follow-up-after-congestive-heart-failure-exacerbation-use-of-a-quality-and-safety-award
#30
JOURNAL ARTICLE
Lea M Monday, Joseph Sebastian, Paul Nguyen, Omid Yazdanpanah, Caleb Solokowski, Jane Chi, Kareem Bazzy
OBJECTIVES: Congestive heart failure (CHF) is the most common cause of 30-day inpatient readmission. Studies have found that early follow-up with primary care physicians (PCP) within 7 days of discharge may improve 30-day readmission rates; however, many have used a multidisciplinary discharge coordination team, which is not a resource at all centers. Here, the authors present a resident-driven quality improvement initiative using a monthly quality and safety award to increase early PCP follow-up for veterans discharged following admissions due to a CHF exacerbation...
January 4, 2022: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://read.qxmd.com/read/34882080/efficacy-of-trimetazidine-an-inhibitor-of-free-fatty-acids-oxidation-in-the-treatment-of-patients-with-stable-angina-pectoris-and-heart-failure
#31
JOURNAL ARTICLE
M G Bubnova, D M Aronov
Aim      To evaluate efficacy of modified-release trimetazidine (TMZ) included into the standard therapy for patients with stable angina and chronic heart failure (CHF) as a part of a subgroup analysis in the PERSPECTIVE study.Material and methods  The study included 806 patients: group 1 (n=691), patients receiving a standard therapy and modified-release TMZ (TMZ group); and group 2 (n=115), patients receiving a standard therapy (control group). Total duration of the study was 12 months.Results In the TMZ group, the weekly number of angina attacks decreased by 41...
November 30, 2021: Kardiologiia
https://read.qxmd.com/read/34849103/cholinergic-elicitation-prevents-ventricular-remodeling-via-alleviations-of-myocardial-mitochondrial-injury-linked-to-inflammation-in-ischemia-induced-chronic-heart-failure-rats
#32
JOURNAL ARTICLE
Yang Zhao, Huaxin Sun, Kai Li, Luxiang Shang, Xiaoyan Liang, Hang Yang, Zhenyu Dong, Jiasuoer Xiaokereti, Shuai Shang, Qina Zhou, Xianhui Zhou, Ling Zhang, Yanmei Lu, Baopeng Tang
BACKGROUND: Cholinergic anti-inflammatory pathway (CAP) is implicated in cardioprotection in chronic heart failure (CHF) by downregulating inflammation response. Mitochondrial injuries play an important role in ventricular remodeling of the CHF process. Herein, we aim to investigate whether CAP elicitation prevents ventricular remodeling in CHF by protecting myocardial mitochondrial injuries and its underlying mechanisms. METHODS AND RESULTS: CHF models were established by ligation of anterior descending artery for 5 weeks...
2021: Mediators of Inflammation
https://read.qxmd.com/read/34763643/-possibilities-and-limitations-of-the-use-of-beta-blockers-in-patients-with-cardiovascular-disease-and-chronic-obstructive-pulmonary-disease
#33
JOURNAL ARTICLE
N A Karoli, A P Rebrov
In medical literature, increasing attention is paid to comorbidities in patients with chronic obstructive pulmonary disease (COPD). In clinical practice, physicians often hesitate to prescribe beta-blockers (β1-adrenoblockers) to COPD patients. This article summarized new results of using beta-blockers in patients with COPD. According to reports, the selective β1-blocker treatment considerably increases the survival rate of patients with COPD and ischemic heart disease, particularly after myocardial infarction (MI), and with chronic heart failure (CHF)...
October 30, 2021: Kardiologiia
https://read.qxmd.com/read/34731695/experiencing-the-possibility-of-near-death-on-a-daily-basis-a-phenomenological-study-of-patients-with-chronic-heart-failure
#34
JOURNAL ARTICLE
Maddi Olano-Lizarraga, Jesús Martín-Martín, Mercedes Pérez-Díez Del Corral, Maribel Saracíbar-Razquin
BACKGROUND: Chronic heart failure (CHF) is a syndrome that greatly impacts people's lives. Due to the poor prognosis of CHF, together with the frequent exacerbations of symptoms, death is a topic that is very present in the lives of patients with CHF. OBJECTIVE: To explore thoughts about death experienced by patients with chronic heart failure in their daily lives. METHODS: A hermeneutic phenomenological study was carried out. Conversational interviews were conducted with 20 outpatients with chronic heart failure...
January 2022: Heart & Lung: the Journal of Critical Care
https://read.qxmd.com/read/34635743/polymorphism-of-the-itgam-gene-rs7193943-and-bioelectric-impedance-analysis-as-potential-predictors-of-cachexia-in-chronic-heart-failure
#35
JOURNAL ARTICLE
Grzegorz Sobieszek, Radosław Mlak, Tomasz Powrózek, Marcin Mazurek, Aneta Skwarek-Dziekanowska, Piotr Terlecki, Teresa Małecka-Massalska
Cardiac cachexia (CC) is an unfavorable metabolic syndrome leading to exacerbation of chronic heart failure (CHF) and a higher risk of death. The main factor contributing to the development of cachexia is the ongoing inflammatory process mediated by genes (e.g. Integrin Subunit Alpha M-ITGAM). The study aimed to assess the relationship between a single nucleotide polymorphism (SNP) -323G > A of the ITGAM and the occurrence of nutritional disorders in patients with CHF. 157 CHF patients underwent clinical and nutritional screening...
October 11, 2021: Scientific Reports
https://read.qxmd.com/read/34465456/prognosticators-of-all-cause-mortality-in-patients-with-heart-failure-with-preserved-ejection-fraction
#36
JOURNAL ARTICLE
Jack B Lopuszynski, Alicia J Downing, Colleen M Finley, Maliha Zahid
Heart failure with preserved ejection fraction (HFpEF) represents ∼50% of all cases of congestive heart failure (CHF) with prevalence expected to increase with aging of the population. We performed an observational study of all patients admitted to 3 hospitals in the ExcelaHealth care system, Greensburg, PA, with a primary diagnosis of HFpEF heart failure exacerbation between January 2014 and January 2017. Demographic data, laboratory results, and echocardiograms performed closest to index hospitalization were collected...
November 1, 2021: American Journal of Cardiology
https://read.qxmd.com/read/34290502/adherence-to-an-ehealth-self-management-intervention-for-patients-with-both-copd-and-heart-failure-results-of-a-pilot-study
#37
JOURNAL ARTICLE
Joanne Sloots, Mirthe Bakker, Job van der Palen, Michiel Eijsvogel, Paul van der Valk, Gerard Linssen, Clara van Ommeren, Martijn Grinovero, Monique Tabak, Tanja Effing, Anke Lenferink
Background: Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) often coexist and share periods of symptom deterioration. Electronic health (eHealth) might play an important role in adherence to interventions for the self-management of COPD and CHF symptoms by facilitating and supporting home-based care. Methods: In this pilot study, an eHealth self-management intervention was developed based on paper versions of multi-morbid exacerbation action plans and evaluated in patients with both COPD and CHF...
2021: International Journal of Chronic Obstructive Pulmonary Disease
https://read.qxmd.com/read/34257710/bmp-2-alleviates-heart-failure-with-type-2-diabetes-mellitus-and-doxorubicin-induced-ac16-cell-injury-by-inhibiting-nlrp3-inflammasome-mediated-pyroptosis
#38
JOURNAL ARTICLE
Jia-Mei Zhang, Rui-Qun Yu, Feng-Zhu Wu, Liang Qiao, Xiao-Rong Wu, Ying-Jie Fu, Yue-Feng Liang, Yu Pang, Chun-Yi Xie
Chronic heart failure (CHF) and diabetes mellitus are associated with morbidity and mortality. CHF and diabetes generally simultaneously occur, resulting in adverse outcomes. Diabetes complicates cardiomyopathy and exacerbates heart failure conditions. An increase in natriuretic peptides, including atrial natriuretic peptide (ANP), and another endsogenously generated peptide, brain natriuretic peptide (BNP), serves an essential role in CHF. The aim of this study was to explore the molecular regulation between bone morphogenetic protein-2 (BMP-2) and ANP or BNP in diabetes-associated cardiomyopathy...
August 2021: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/34141505/all-cause-mortality-and-incidence-of-major-adverse-cardiac-events-in-sickle-cell-nephropathy-a-comparative-study
#39
JOURNAL ARTICLE
Kunjan Udani, Nayda Parisio-Poldiak, Julia Campbell, Victor Collier, Pooja Patel
Background Sickle cell disease (SCD) is an autosomal recessive disease resulting in hemolytic anemia and recurrent vaso-occlusive events. Consequently, it can result in a broad range of functional and structural renal and cardiac alterations. Chronic kidney disease (CKD), in SCD, is associated with proteinuria, microalbuminuria, and hemoglobinuria. Cardiac complications in SCD include pulmonary hypertension, left ventricular diastolic heart disease, dysrhythmia, and sudden death. In patients with advancing age, cardio-renal dysfunction can have substantial effects on morbidity and mortality...
May 16, 2021: Curēus
https://read.qxmd.com/read/34125045/performance-of-emergency-heart-failure-mortality-risk-grade-in-the-emergency-department
#40
JOURNAL ARTICLE
Nidhi Garg, Renee Pekmezaris, Gerin Stevens, Adan Z Becerra, Andrzej Kozikowski, Vidhi Patel, Ghania Haddad, Phillip Levy, Pridha Kumar, Lance Becker
INTRODUCTION: The purpose of this study was to validate and assess the performance of the Emergency Heart Failure Mortality Risk Grade (EHMRG) to predict seven-day mortality in US patients presenting to the emergency department (ED) with acute congestive heart failure (CHF) exacerbation. METHODS: We performed a retrospective chart review on patients presenting to the ED with acute CHF exacerbation between January 2014-January 2016 across eight EDs in New York. We identified patients using codes from the International Classification of Diseases, 9th and 10 Revisions, or who were diagnosed with CHF in the ED...
April 8, 2021: Western Journal of Emergency Medicine
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