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https://www.readbyqxmd.com/read/28665906/characteristics-of-patients-with-congestive-heart-failure-or-chronic-obstructive-pulmonary-disease-readmissions-within-30-days-following-an-acute-exacerbation
#1
Austin Castillo, Hawa Edriss, Kavitha Selvan, Kenneth Nugent
BACKGROUND: The Hospital Readmissions Reduction Program targets Medicare patients with congestive heart failure (CHF) and chronic obstructive pulmonary disease (COPD) and penalizes hospitals that have increased 30-day readmission rates for these patients. The main goals of this study were to determine the clinical explanations for readmissions within 30 days, to identify possible deficiencies in patient care, and to identify typical characteristics of patients who were readmitted to the hospital...
July 2017: Quality Management in Health Care
https://www.readbyqxmd.com/read/28508293/influenza-infection-and-heart-failure-vaccination-may-change-heart-failure-prognosis
#2
REVIEW
Nikolaos P E Kadoglou, Frank Bracke, Tim Simmers, Sotirios Tsiodras, John Parissis
The interaction of influenza infection with the pathogenesis of acute heart failure (AHF) and the worsening of chronic heart failure (CHF) is rather complex. The deleterious effects of influenza infection on AHF/CHF can be attenuated by specific immunization. Our review aimed to summarize the efficacy, effectiveness, safety, and dosage of anti-influenza vaccination in HF. In this literature review, we searched MEDLINE and EMBASE from January 1st 1966 to December 31st, 2016, for studies examining the association between AHF/CHF, influenza infections, and anti-influenza immunizations...
May 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28181258/cardiac-diastolic-and-autonomic-dysfunction-are-aggravated-by-central-chemoreflex-activation-in-heart-failure-with-preserved-ejection-fraction-rats
#3
Camilo Toledo, David C Andrade, Claudia Lucero, Alexis Arce-Alvarez, Hugo S Díaz, Valentín Aliaga, Harold D Schultz, Noah J Marcus, Mónica Manríquez, Marcelo Faúndez, Rodrigo Del Rio
KEY POINTS: Heart failure with preserved ejection fraction (HFpEF) is associated with disordered breathing patterns, and sympatho-vagal imbalance. Although it is well accepted that altered peripheral chemoreflex control plays a role in the progression of heart failure with reduced ejection fraction (HFrEF), the pathophysiological mechanisms underlying deterioration of cardiac function in HFpEF are poorly understood. We found that central chemoreflex is enhanced in HFpEF and neuronal activation is increased in pre-sympathetic regions of the brainstem...
April 15, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28119150/vascular-katp-channels-mitigate-severe-muscle-o2-delivery-utilization-mismatch-during-contractions-in-chronic-heart-failure-rats
#4
Clark T Holdsworth, Scott K Ferguson, Trenton D Colburn, Alexander J Fees, Jesse C Craig, Daniel M Hirai, David C Poole, Timothy I Musch
The vascular ATP-sensitive K(+) (KATP) channel is a mediator of skeletal muscle microvascular oxygenation (PO2mv) during contractions in health. We tested the hypothesis that KATP channel function is preserved in chronic heart failure (CHF) and therefore its inhibition would reduce PO2mv and exacerbate the time taken to reach the PO2mv steady-state during contractions of the spinotrapezius muscle. Moreover, we hypothesized that subsequent KATP channel activation would oppose the effects of this inhibition. Muscle PO2mv (phosphorescence quenching) was measured during 180s of 1-Hz twitch contractions (∼6V) under control, glibenclamide (GLI, KATP channel antagonist; 5mg/kg) and pinacidil (PIN, KATP channel agonist; 5mg/kg) conditions in 16 male Sprague-Dawley rats with CHF induced via myocardial infarction (coronary artery ligation, left ventricular end-diastolic pressure: 18±1mmHg)...
April 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27898735/cognitive-dysfunction-and-malnutrition-are-independent-predictor-of-dysphagia-in-patients-with-acute-exacerbation-of-congestive-heart-failure
#5
Junichi Yokota, Yoshiko Ogawa, Shinsuke Yamanaka, Yoshimi Takahashi, Hiroshi Fujita, Nobuhiro Yamaguchi, Noriko Onoue, Takeshi Ishizuka, Tsuyoshi Shinozaki, Masahiro Kohzuki
Early detection and intervention for dysphagia is important in patients with congestive heart failure (CHF). However, previous studies have focused on how many patients with dysphagia develop CHF. Studies focusing on the comorbidity of dysphagia in patients with CHF are rare. Additionally, risk factors for dysphagia in patients with CHF are unclear. Thus, the aim of this study was to clarify risk factors for dysphagia in patients with acute exacerbation of CHF. A total of 105 patients, who were admitted with acute exacerbation of CHF, were enrolled...
2016: PloS One
https://www.readbyqxmd.com/read/27824514/30-day-readmission-rates-in-patients-admitted-for-heart-failure-exacerbation-with-and-without-palliative-care-consultation-a-retrospective-cohort-study
#6
Elizabeth Chuang, Gina Kim, Arthur E Blank, William Southern, James Fausto
BACKGROUND: Palliative care consultation improves quality of care through symptom management, communication, care coordination, and earlier hospice referral, and it may decrease burdensome hospital readmissions at the end of life. OBJECTIVES: To compare 30-day readmission rates for patients admitted with exacerbation of congestive heart failure (CHF) receiving palliative care consultation services compared with controls. DESIGN: Retrospective cohort study using propensity score matching...
February 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/27714717/annual-prognostic-factors-in-chronic-heart-failure-in-patients-over-80-years-old
#7
Anna Cichocka-Radwan, Małgorzata Lelonek
BACKGROUND: In the elderly the most common cause of hospitalisation and the leading cause of death is heart failure (HF). AIM: The purpose was to determine prognostic factors in chronic HF (CHF) in octogenarians and nonagenarians. METHODS: The analysis included 197 consecutive patients over 80 years old (mean age 83.63 ± 3.01 years; 46.19% men) hospitalised in 2010-2013 due to CHF. Sixty-two parameters were investigated, such as: age, gender, New York Heart Asso-ciation functional class, body mass index, blood pressure, other comorbidities, the parameters of the 12-lead resting electro-cardiography and the echocardiography, the results of basic laboratory tests, and selected biomarkers, including N-terminal pro-B-type natriuretic peptide, high-sensitive troponin T (hs-TnT), and high-sensitive C-reactive protein...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/27692135/evaluation-of-chronic-obstructive-pulmonary-disease-copd-and-reduced-ejection-fraction-heart-failure-hrref-discharge-medication-prescribing-is-drug-therapy-concordant-with-national-guidelines-associated-with-a-reduction-in-30-day-readmissions
#8
Amy Richardson, Elizabeth Tolley, Jonathan Hartmann, Jasmine Reedus, Brandi Bowlin, Christopher Finch, Christopher W Sands, Timothy Self
INTRODUCTION: Approximately 1 in 5 hospitalized COPD patients are readmitted within 30 days of discharge. CHF coexists in more than 20% of patients with COPD, and is associated with early readmission for COPD. Reducing 30-day hospital readmissions for COPD is of intense current interest. METHODOLOGY: A retrospective chart review was performed to identify patients discharged with COPD exacerbation and HFrEF. The primary objective was to evaluate if discharge medication prescribing following guidelines for both COPD and HFrEF correlates with reduced 30-day readmission rates...
October 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27685859/direction-of-the-relationship-between-acceptance-of-illness-and-health-related-quality-of-life-in-chronic-heart-failure-patients
#9
Monika Obiegło, Agnieszka Siennicka, Ewa A Jankowska, Dariusz P Danel
BACKGROUND: This study provides an in-depth insight into the relationships between illness acceptance and health-related quality of life (HRQoL) of chronic heart failure (CHF) patients. Although HRQoL is a well-established endpoint in CHF, little is known on illness acceptance in this group. AIMS: The aim of this study is to critically reconsider the direction of a relationship between HRQoL and illness acceptance in CHF patients. METHODS: The study included 204 patients (160 men and 44 women; mean age, 63 ± 11 years) with at least 6-month clinical evidence of CHF corresponding to New York heart Association (NYHA) classes I to IV...
July 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/27659741/a-multidisciplinary-telehealth-program-in-patients-with-combined-chronic-obstructive-pulmonary-disease-and-chronic-heart-failure-study-protocol-for-a-randomized-controlled-trial
#10
Palmira Bernocchi, Simonetta Scalvini, Tiziana Galli, Mara Paneroni, Doriana Baratti, Ottavia Turla, Maria Teresa La Rovere, Maurizio Volterrani, Michele Vitacca
BACKGROUND: Chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF) frequently coexist, significantly reducing patients' quality of life and increasing morbidity and mortality. For either single disease, a multidisciplinary disease-management approach supported by telecommunication technologies offers the best outcome in terms of prolonged survival and reduced hospital readmissions. However, no data exist in patients with combined COPD/CHF. We planned a randomized controlled trial to investigate the feasibility and efficacy of an integrated, home-based, medical/nursing intervention plus a rehabilitation program versus conventional care in patients with coexisting COPD/CHF...
September 22, 2016: Trials
https://www.readbyqxmd.com/read/27598860/does-thiazolidinedione-therapy-exacerbate-fluid-retention-in-congestive-heart-failure
#11
REVIEW
Ilia Goltsman, Emad E Khoury, Joseph Winaver, Zaid Abassi
The ever-growing global burden of congestive heart failure (CHF) and type 2 diabetes mellitus (T2DM) as well as their co-existence necessitate that anti-diabetic pharmacotherapy will modulate the cardiovascular risk inherent to T2DM while complying with the accompanying restrictions imposed by CHF. The thiazolidinedione (TZD) family of peroxisome proliferator-activated receptor γ (PPARγ) agonists initially provided a promising therapeutic option in T2DM owing to anti-diabetic efficacy combined with pleiotropic beneficial cardiovascular effects...
December 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27592865/bone-morphogenetic-protein-6-a-possible-new-player-in-pathophysiology-of-heart-failure
#12
LETTER
Joanna Banach, Wojciech Gilewski, Artur Słomka, Katarzyna Buszko, Jan Błażejewski, Danuta Karasek, Daniel Rogowicz, Ewa Żekanowska, Wadyslaw Sinkiewicz
Derangement of bone morphogenetic protein (BMP) signalling was observed in cardiovascular disorders. The present study assesses the diagnostic and prognostic value of BMP6 plasma concentration in chronic heart failure (CHF). 130 CHF patients and 32 controls participated in the study. BMP6 plasma level was measured at baseline. During 12-month follow-up death and hospitalisation with CHF exacerbation were recorded. BMP6 was significantly increased in CHF patients with highest concentration in most advanced disease...
December 2016: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27440625/implementation-of-an-emergency-department-based-clinical-pharmacist-transitions-of-care-program
#13
Elizabeth Hohner, Melinda Ortmann, Umbreen Murtaza, Sheeva Chopra, Patricia A Ross, Meghan Swarthout, Leigh Efird, Emily Pherson, Mustapha Saheed
PURPOSE: The implementation of an emergency department (ED)-based clinical pharmacist transitions-of-care (TOC) program is described. SUMMARY: The intervention program consisted of collaboration between ED and ambulatory care pharmacists to provide patient-specific comprehensive medication review and education in the ED setting and to help ensure a coordinated transition to the ambulatory care setting by scheduling an ambulatory pharmacy clinic or home-based visit...
August 1, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27403182/tolvaptan-a-novel-diuretic-in-heart-failure-management
#14
REVIEW
Hilman Zulkifli Amin, Siska Suridanda Danny
Heart failure (HF) is still a major problem worldwide with high morbidity and mortality rates. The recently developed medication for HF is still incapable of reducing its morbidity and mortality, and clinical data supporting the efficacy and safety of its mainstay therapy remain insufficient. Arginine-vasopressin (AVP) plays important roles in circulatory and water homeostasis, one of which is water retention through the V2 receptor. In patients with HF, there is an increased level of AVP, contributing to such symptoms as edema, dyspnea, and congestion...
January 13, 2016: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/27355366/melanoma-cell-adhesion-molecule-as-an-emerging-biomarker-with-prognostic-significance-in-systolic-heart-failure
#15
Joanna Banach, Magdalena Grochowska, Lidia Gackowska, Katarzyna Buszko, Robert Bujak, Wojciech Gilewski, Izabela Kubiszewska, Łukasz Wołowiec, Jacek Michałkiewicz, Władysław Sinkiewicz
BACKGROUND: Melanoma cell adhesion molecule (MCAM) is a marker of endothelial damage. MCAM diagnostic and prognostic value was assessed in chronic heart failure (CHF). MATERIALS & METHODS: 130 CHF patients and 32 controls were included in the study. Telephone follow-up lasted one year. End points were: death from all causes, and hospitalization with CHF exacerbation. RESULTS: MCAM was higher in patients than in controls (p = 0.01). Receiver operator curve analysis revealed that MCAM may serve as a predictor of death (area under the curve: 0...
July 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27263064/prognostic-impact-of-comorbidities-in-hospitalized-patients-with-acute-exacerbation-of-chronic-heart-failure
#16
Domenico Scrutinio, Andrea Passantino, Pietro Guida, Enrico Ammirati, Fabrizio Oliva, Simona Sarzi Braga, Maria Teresa La Rovere, Rocco Lagioia, Maria Frigerio
BACKGROUND: To assess the impact of comorbidities on long-term all-cause mortality in patients hospitalized with exacerbated signs/symptoms of previously chronic stable HF (AE-CHF). METHODS: 1119 patients admitted for AE-CHF and with NT-proBNP levels >900pg/mL were enrolled. Univariable and multivariable Cox analyses were performed to assess the association of age, gender, hypertension, diabetes, obesity, atrial fibrillation, coronary heart disease (CHD), chronic obstructive pulmonary disease, previous cerebrovascular accidents, chronic liver disease (CLD), thyroid disease, renal impairment (RI), and anemia with 3-year all-cause mortality...
October 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27218485/contribution-of-peripheral-and-central-chemoreceptors-to-sympatho-excitation-in-heart-failure
#17
Camilo Toledo, David C Andrade, Claudia Lucero, Harold D Schultz, Noah Marcus, Mauricio Retamal, Carlos Madrid, Rodrigo Del Rio
Chronic heart failure (CHF) is a major public health problem. Tonic hyper-activation of sympathetic neural outflow is commonly observed in patients with CHF. Importantly, sympatho-excitation in CHF exacerbates its progression and is strongly related to poor prognosis and high mortality risk. Increases in both peripheral and central chemoreflex drive are considered markers of the severity of CHF. The principal peripheral chemoreceptors are the carotid bodies (CBs) and alteration in their function has been described in CHF...
January 1, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/27169297/thirty-day-readmissions-after-pneumonia-how-many-are-preventable
#18
Vanessa Yap, Rahul Mutneja, Mark Metersky
INTRODUCTION: Pneumonia remains a continuing target for performance measurement and quality improvement. The aim of this analysis was to examine 30-day all-cause readmissions after pneumonia to identify reasons for readmission and potential opportunities for improvement. METHODS: A retrospective chart review was performed on patients readmitted within 30 days after an index pneumonia hospitalization at the University of Connecticut Health Center in 2011. RESULTS: There were 54 readmissions involving 40 patients and only five (12...
March 2016: Connecticut Medicine
https://www.readbyqxmd.com/read/27109795/the-effect-of-congestive-heart-failure-on-perioperative-outcomes-in-patients-undergoing-lower-extremity-revascularization
#19
MULTICENTER STUDY
Richard L Amdur, Bernard Ashby, Richard Neville, Aundrea Tunstall, Bao-Ngoc Nguyen, Anton Sidawy
BACKGROUND: As the management of peripheral arterial disease evolves, determining the factors affecting the outcome of lower extremity interventions is important. The presence of peripheral arterial disease is associated with a twofold increase in the prevalence of congestive heart failure (CHF), with reports of increased perioperative complications. This study evaluated CHF as a predictor of acute postoperative complications in patients undergoing lower extremity bypass. METHODS: The study group consisted of all patients entered in a prospective, multicenter database (American College of Surgeons National Surgical Quality Improvement Program) undergoing infrainguinal bypass (IIB) from 2005 to 2010...
May 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27064361/evaluation-of-the-efficacy-of-a-nurse-practitioner-led-home-based-congestive-heart-failure-clinical-pathway
#20
Jo-Ann Mary Moore
Frequent exacerbations of symptoms and financial penalties for 30-day hospital readmissions of patients with congestive heart failure (CHF) have led to new disease management approaches. A nurse practitioner (NP)-led interdisciplinary program for CHF management that included home telemonitoring and early NP assessments and interventions was piloted by a home health agency. A 4-month evaluation of the efficacy of a clinical pathway for CHF patients resulted in the enrollment of 22 CHF patients in the program...
January 2016: Home Health Care Services Quarterly
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