keyword
https://read.qxmd.com/read/38537151/development-and-validation-of-a-machine-learning-prognostic-model-of-m5c-related-immune-genes-in-lung-adenocarcinoma
#1
JOURNAL ARTICLE
Xiong Cao, Yuxing Ji, Jiajia Li, Zhikang Liu, Chang Chen
BACKGROUND: The aim of this retrospective research was to develop an immune-related genes significantly associated with m5C methylation methylation (m5C-IRGs)-related signature associated with lung adenocarainoma (LUAD). METHODS: We introduced transcriptome data to screen out m5C-IRGs in The Cancer Genome Atlas (TCGA)-LUAD dataset. Subsequently, the m5C-IRGs associated with survival were certificated by Kaplan Meier (K-M) analysis. The univariate Cox, least absolute shrinkage and selection operator (LASSO) regression, and xgboost...
2024: Cancer Control: Journal of the Moffitt Cancer Center
https://read.qxmd.com/read/38537073/the-role-of-robotic-assisted-surgery-in-the-management-of-rectal-cancer-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Chenxion Zhang, Hao Tan, Han Xu, Jiaming Ding
BACKGROUND: Rectal cancer poses a significant global health burden. There is a lack of concrete evidence concerning the benefits of robotic-assisted surgery (RAS) for rectal cancer surgery as compared to laparoscopic and open techniques. To address this gap, we conducted a meta-analysis to assess the intraoperative, postoperative, and safety outcomes of robotic surgery in this context. METHODS: MEDLINE, Scopus, and the Cochrane library were searched till May 2023 for randomized and non-randomized studies comparing robotic surgery with either laparoscopic or open approach for rectal cancers...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537064/a-commentary-on-mapping-the-landscape-of-immunonutrition-and-cancer-research-a-comprehensive-bibliometric-analysis-on-behalf-of-nutrionc-research-group
#3
JOURNAL ARTICLE
Lin Wang, Yongcheng Wang, Xiao Li
No abstract text is available yet for this article.
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537058/a-commentary-on-global-research-status-and-frontiers-on-autophagy-in-hepatocellular-carcinoma-a-comprehensive-bibliometric-and-visualized-analysis
#4
JOURNAL ARTICLE
Sike He, Hao Zeng
No abstract text is available yet for this article.
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537055/a-commentary-on-worldwide-research-trends-on-tumor-burden-and-immunotherapy-a-bibliometric-analysis
#5
JOURNAL ARTICLE
Lele Miao, Juan Zhang, Chaoyan Shen, Wei Wang
No abstract text is available yet for this article.
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536851/the-motivations-and-experiences-of-specialists-who-provide-outreach-services-in-rural-operating-rooms-a-survey-study-from-british-columbia
#6
JOURNAL ARTICLE
Anshu Parajulee, Kathrin Stoll, Nancy Humber, Sean Ebert, Kim Williams, Jude Kornelsen
INTRODUCTION: Outreach care has long been used in Canada to address the lack of access to specialist care in rural settings, but research on the experiences of specialists providing these services is lacking. This descriptive survey study aimed to understand 1) specialists' motivation for engaging in outreach work, (2) their perceptions of the quality of care at their rural outreach hospital, and (3) the supports they receive for their outreach work, in order to create a supportive framework to encourage specialist outreach contributions...
2024: PloS One
https://read.qxmd.com/read/38536823/does-the-incorporation-of-graphene-oxide-into-pmma-influence-its-antimicrobial-activity
#7
JOURNAL ARTICLE
I Ferreira, B D Sahm, O L Alves, J A M Agnelli, A C Dos Reis
INTRODUCTION: The increase in infectious diseases mediated by oral bacteria has been one of the most potent threats to human health, specifically to the elderly. Researchers seek to incorporate antimicrobial nanomaterials into PMMA to control the colonization of microorganisms and reduce deadly diseases. OBJECTIVE: To conduct a systematic review to answer the question: "Does graphene oxide incorporated into polymethylmethacrylate influence its antimicrobial activity?" METHODS: The electronic search was performed in PubMed, Embase, Web of Science, Scopus, and Google Scholar databases, and articles published until October 2021 were selected...
March 12, 2024: European Journal of Prosthodontics and Restorative Dentistry
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#8
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#9
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536581/diagnostic-performance-of-ultrasound-in-the-assessment-of-gastric-contents-a-meta-analysis-and-systematic-review
#10
REVIEW
Xuanyuan Pan, Jun Chai, Xin Gao, Si Li, Jie Liu, Linxing Li, Yanjing Li, Zhichao Li
OBJECTIVE: To systematically analyze the accuracy of ultrasonic techniques in assessing the nature of gastric contents and their volume. METHODS: English-language articles that used ultrasonic techniques to assess the nature of gastric contents and their volume in patients were selected. In eligible studies, data were recalculated and analyzed for forest plots and subject summary curves of operating characteristics (SROC). Study quality was assessed using the diagnostic accuracy study quality assessment tool QUADAS-2...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536579/cell-cycle-related-protein-centromere-protein-f-deficiency-inhibits-cervical-cancer-cell-growth-by-inducing-ferroptosis-via-nrf2-inactivation
#11
JOURNAL ARTICLE
Xin Hui Tang, Tian Nan Zhao, Li Guo, Xin Yue Liu, Wei Na Zhang, Ping Zhang
Cervical cancer (CC) is one of the severe cancers that pose a threat to women's health and result in death. CENPF, the centromere protein F, plays a crucial role in mitosis by regulating numerous cellular processes, such as chromosome segregation during mitosis. According to bioinformatics research, CENPF serves as a master regulator that is upregulated and activated in cervical cancer. Nevertheless, the precise biological mechanism that CENPF operates in CC remains unclear. The aim of this study was to analyze the function of CENPF on cervical cancer and its mechanism...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#12
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38536223/assessment-of-patient-safety-in-a-low-resource-health-care-system-proposal-for-a-multimethod-study
#13
JOURNAL ARTICLE
Ghazal Haque, Fozia Asif, Fasih Ali Ahmed, Farwa Ayub, Sabih Ul Hassan Syed, Nousheen Akber Pradhan, Malika Hameed, Muhammad Muneeb Ullah Siddiqui, Shafaq Mahmood, Tahani Zaidi, Sameen Siddiqi, Asad Latif
BACKGROUND: The high prevalence of adverse events (AEs) globally in health care delivery has led to the establishment of many guidelines to enhance patient safety. However, patient safety is a relatively nascent concept in low- and middle-income countries (LMICs) where health systems are already overburdened and underresourced. This is why it is imperative to study the nuances of patient safety from a local perspective to advocate for the judicious use of scarce public health resources...
March 27, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38536187/validation-of-a-multivariable-model-to-predict-suicide-attempt-in-a-mental-health-intake-sample
#14
JOURNAL ARTICLE
Santiago Papini, Honor Hsin, Patricia Kipnis, Vincent X Liu, Yun Lu, Kristine Girard, Stacy A Sterling, Esti M Iturralde
IMPORTANCE: Given that suicide rates have been increasing over the past decade and the demand for mental health care is at an all-time high, targeted prevention efforts are needed to identify individuals seeking to initiate mental health outpatient services who are at high risk for suicide. Suicide prediction models have been developed using outpatient mental health encounters, but their performance among intake appointments has not been directly examined. OBJECTIVE: To assess the performance of a predictive model of suicide attempts among individuals seeking to initiate an episode of outpatient mental health care...
March 27, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38536062/finite-difference-embedded-unet-for-solving-transcranial-ultrasound-frequency-domain-wavefield
#15
JOURNAL ARTICLE
Linfeng Wang, Jian Li, Shili Chen, Zheng Fan, Zhoumo Zeng, Yang Liu
Transcranial ultrasound imaging assumes a growing significance in the detection and monitoring of intracranial lesions and cerebral blood flow. Accurate solution of partial differential equation (PDE) is one of the prerequisites for obtaining transcranial ultrasound wavefields. Grid-based numerical solvers such as finite difference (FD) and finite element methods have limitations including high computational costs and discretization errors. Purely data-driven methods have relatively high demands on training datasets...
March 1, 2024: Journal of the Acoustical Society of America
https://read.qxmd.com/read/38536054/recent-advances-in-the-interfacial-engineering-of-mof-based-mixed-matrix-membranes-for-gas-separation
#16
REVIEW
Shuwen Yu, Conger Li, Shuke Zhao, Milton Chai, Jingwei Hou, Rijia Lin
The membrane process stands as a promising and transformative technology for efficient gas separation due to its high energy efficiency, operational simplicity, low environmental impact, and easy up-and-down scaling. Metal-organic framework (MOF)-polymer mixed matrix membranes (MMMs) combine MOFs' superior gas-separation performance with polymers' processing versatility, offering the opportunity to address the limitations of pure polymer or inorganic membranes for large-scale integration. However, the incompatibility between the rigid MOFs and flexible polymer chains poses a challenge in MOF MMM fabrication, which can cause issues such as MOF agglomeration, sedimentation, and interfacial defects, substantially weakening membrane separation efficiency and mechanical properties, particularly gas separation...
March 27, 2024: Nanoscale
https://read.qxmd.com/read/38536039/the-nature-of-combat-stress-development-during-military-operations-and-psychotherapy-in-extreme-situations
#17
JOURNAL ARTICLE
Yanina Ovsyannikova, Diana Pokhilko, Mykola Krasnokutskyi, Valentyn Kerdyvar, Kateryna Kreshchuk
The purpose of the research work is the theoretical and empirical analysis of the study of the nature of combat stress in military personnel and the assessment of psychotherapeutic methods of providing psychological assistance in extreme situations. The authors used the following methods to achieve this goal: method of analysis and synthesis, hermeneutic method, testing method, comparative method, and generalization method. The results of the research work have revealed the meaning of traumatic stress, psychological trauma, and combat mental trauma, and explained the concept of combat stress and the dynamics of its growth...
March 13, 2024: Journal of Nervous and Mental Disease
https://read.qxmd.com/read/38535916/advancing-endocrine-disruptors-via-in-vitro-evaluation-recognizing-the-significance-of-the-organization-for-economic-co-operation-and-development-and-united-states-environmental-protection-agency-guidelines-embracing-new-assessment-methods-and-the-urgent-need
#18
REVIEW
Sophie Fouyet, Marie-Caroline Ferger, Pascale Leproux, Patrice Rat, Mélody Dutot
Efforts are being made globally to improve the evaluation and understanding of endocrine-disrupting chemicals. Recognition of their impact on human health and the environment has stimulated attention and research in this field. Various stakeholders, including scientists, regulatory agencies, policymakers, and industry representatives, are collaborating to develop robust methodologies and guidelines for assessing these disruptors. A key aspect of these efforts is the development of standardized testing protocols and guidelines that aim to provide consistent and reliable methods for identifying and characterizing endocrine disruptors...
February 28, 2024: Toxics
https://read.qxmd.com/read/38535880/operational-differences-between-product-development-partnership-pharmaceutical-industry-and-investigator-initiated-clinical-trials
#19
JOURNAL ARTICLE
Eric I Nebie, Peter van Eeuwijk, Hélène N Sawadogo, Elisabeth Reus, Jürg Utzinger, Christian Burri
Medicine development is a lengthy endeavour. Increasing regulatory stringency and trial complexity might lead to reduced efficiency, dwindled output, and elevated costs. However, alternative models are possible. We compared the operational differences between pharmaceutical industry sponsored trials, product development partnership trials, and investigator-initiated trials to identify key drivers of inefficiency in clinical research. We conducted an exploratory mixed-methods study with stakeholders, including clinical trial sponsors, contract research organisations, and investigators...
February 29, 2024: Tropical Medicine and Infectious Disease
https://read.qxmd.com/read/38535873/transitional-dynamics-in-oncology-clinical-trials-evaluating-the-impact-of-clinical-trials-act-on-cooperative-groups
#20
JOURNAL ARTICLE
Kenichi Nakamura, Koji Takeda, Akiko M Saito, Miho Kato, Shinya Sato, Satoshi Nakagawa, Yasuyuki Kawamoto, Eiji Oki, Isamu Okamoto, Hiroaki Okamoto, Hiroshi Katayama, Junki Mizusawa, Harumi Kaba, Taro Shibata, Haruhiko Fukuda
OBJECTIVE: large-scale multicentre clinical trials conducted by cooperative groups have generated a lot of evidence to establish better standard treatments. The Clinical Trials Act was enforced on 1 April 2018, in Japan, and it has remarkably increased the operational burden on investigators, but its long-term impact on cancer cooperative groups is unknown. METHODS: a survey was conducted across the nine major cooperative groups that constitute the Japan Cancer Trials Network to assess the impact of Clinical Trials Act on the number of newly initiated trials from fiscal year (from 1 April to 31 March) 2017 to 2022 and that of ongoing trials on 1 April in each year from 2018 to 2023...
March 26, 2024: Japanese Journal of Clinical Oncology
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