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https://www.readbyqxmd.com/read/28927040/overexpression-of-dendritic-cell-specific-intercellular-adhesion-molecule-3-grabbing-nonintegrin-related-protein-in-cervical-cancer-and-correlation-with-squamous-cell-carcinoma-antigen
#1
Xiangdong Wang, Yangmei Jiang, Menglang Yuan, Chunlin Chen, Keyong Wang, Qianshi Zhang, Yunfei Zuo, Shuangyi Ren
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin-related protein (DC-SIGNR) is a type II transmembrane protein that has been reported to bind to various pathogens and participate in immunoregulation and tumorigenesis. However, further research is required to investigate whether the level of DC-SIGNR and cervical cancer are associated. The present study aimed to explore the clinical diagnostic significance of DC-SIGNR in cervical cancer. Immunohistochemical staining of DC-SIGNR was performed in samples from 25 patients with early stage cervical cancer, 14 patients with cervical intraepithelial neoplasia (CIN) and cervical polyp samples from 15 individuals...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926797/experimental-study-of-radiation-dose-rate-at-different-strategic-points-of-the-baec-triga-research-reactor
#2
M Ajijul Hoq, M A Malek Soner, M A Salam, M M Haque, Salma Khanom, S M Fahad
The 3MW TRIGA Mark-II Research Reactor of Bangladesh Atomic Energy Commission (BAEC) has been under operation for about thirty years since its commissioning at 1986. In accordance with the demand of fundamental nuclear research works, the reactor has to operate at different power levels by utilizing a number of experimental facilities. Regarding the enquiry for safety of reactor operating personnel and radiation workers, it is necessary to know the radiation level at different strategic points of the reactor where they are often worked...
September 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28926696/exposure-to-animal-feces-and-human-health-a-systematic-review-and-proposed-research-priorities
#3
Gauthami Penakalapati, Jenna Swarthout, Miranda J Delahoy, Lydia McAliley, Breanna Wodnik, Karen Levy, Matthew C Freeman
Humans can be exposed to pathogens from poorly managed animal feces, particularly in communities where animals live in proximity to humans. This systematic review of peer-reviewed and grey literature examines the human health impacts of exposure to poorly managed animal feces transmitted via water, sanitation, and hygiene (WASH)-related pathways in low- and middle-income countries where household livestock, small-scale animal operations, and free-roaming animals are common. We identify routes of contamination by animal feces, control measures to reduce human exposure, and propose research priorities for further inquiry...
September 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28925498/electronic-diary-for-recording-headaches-triggers-and-medication-use-development-and-evaluation
#4
Siavash Bandarian-Balooch, Paul R Martin, Brenton McNally, Arissa Brunelli, Sharon Mackenzie
OBJECTIVE: To evaluate an e-diary developed for measuring headaches, triggers, and medication consumption, in terms of reliability and validity, and variables such as ease of use and participant compliance. BACKGROUND: For many decades, behavioral treatment of headaches has been evaluated via participants completing paper diaries recording their headaches and associated phenomena. There is some limited evidence supporting the reliability and validity of paper diaries, and criticisms have been offered such as the large amount of effort involved for both participants and researchers...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28924968/predictive-value-of-serum-carbohydrate-antigen-19-9-ca19-9-for-early-mortality-in-advanced-pancreatic-cancer
#5
Pedro L S Usón Junior, Donato Callegaro-Filho, Diogo D G Bugano, Fernando Moura, Fernando C Maluf
INTRODUCTION: Levels of carbohydrate antigen 19-9 (CA19-9) in metastatic pancreatic cancer are used in daily practice as a marker of response to chemotherapy. The association between CA19-9 levels and mortality remains uncertain. This study sought to determine the most accurate level of CA19-9 associated with early mortality, both at diagnosis and during the course of metastatic disease. METHODS: This research is a retrospective analysis of 64 patients with metastatic adenocarcinoma of the pancreas evaluated from January 2010 to December 2015...
September 19, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28924746/visual-long-term-memory-is-not-unitary-flexible-storage-of-visual-information-as-features-or-objects-as-a-function-of-affect
#6
Philipp Spachtholz, Christof Kuhbandner
Research has shown that observers store surprisingly highly detailed long-term memory representations of visual objects after only a single viewing. However, the nature of these representations is currently not well understood. In particular, it may be that the nature of such memory representations is not unitary but reflects the flexible operating of two separate memory subsystems: a feature-based subsystem that stores visual experiences in the form of independent features, and an object-based subsystem that stores visual experiences in the form of coherent objects...
September 18, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28924312/outcome-of-early-surgery-in-infantile-esotropia-our-experience-in-tertiary-care-hospital
#7
Anirudh Singh, J K S Parihar, S K Mishra, R Maggon, Anurag Badhani
BACKGROUND: Infantile esotropia is a convergent strabismus presenting before 6 months of age and is the most common strabismus disorder presenting in the ophthalmology OPD. The dilemma of whether to go for early surgery and how early has been a matter of research for the last 50 years. We describe our results of surgery in infantile esotropia at variable age groups, as well as with different reoperation rates and compare with the results in western literature. METHODS: A prospective study was carried out through a review of 113 cases operated for infantile esotropia between February 2013 and August 2014...
April 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28924283/a-framework-for-laparoscopic-simulations
#8
Osman Hasan, Sohail Iqbal
Due to their numerous advantages, laparoscopic surgical procedures are increasingly becoming common in the operation theatres over the past few decades. Virtual reality training simulators have played a significant role during this transition from traditional to laparoscopic procedures by enhancing surgical skills, such as hand-eye coordination in laparoscopy, and practising surgical scenarios that cannot be easily created using physical models. This paper presents a general framework for such a training simulator while identifying its key components and their specific roles in enhancing various laparoscopic skills...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28924017/in-silico-analysis-of-the-regulation-of-the-photosynthetic-electron-transport-chain-in-c3-plants
#9
Alejandro Morales, Xinyou Yin, Jeremy Harbinson, Steven Michiel Driever, Jaap Molenaar, David M Kramer, Paul Struik
We present a new simulation model of the reactions in the photosynthetic electron transport chain of C3 species. We show that including recent insights about the regulation of the thylakoid proton motive force, ATP/NADPH balancing mechanisms (cyclic and non-cyclic alternative electron transport), and regulation of Rubisco activity, leads to emergent behaviors that may affect the operation and regulation of photosynthesis under different dynamic environmental conditions. The model was parameterized with experimental results in the literature, with a focus on Arabidopsis thaliana...
September 18, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28923076/improving-the-performance-of-community-health-workers-in-swaziland-findings-from-a-qualitative-study
#10
Pascal Geldsetzer, Jan-Walter De Neve, Chantelle Boudreaux, Till Bärnighausen, Thomas J Bossert
BACKGROUND: The performance of community health workers (CHWs) in Swaziland has not yet been studied despite the existence of a large national CHW program in the country. This qualitative formative research study aimed to inform the design of future interventions intended to increase the performance of CHW programs in Swaziland. Specifically, focusing on four CHW programs, we aimed to determine what potential changes to their program CHWs and CHW program managers perceive as likely leading to improved performance of the CHW cadre...
September 18, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28923016/5-hydroxymethylcytosine-is-highly-dynamic-across-human-fetal-brain-development
#11
Helen Spiers, Eilis Hannon, Leonard C Schalkwyk, Nicholas J Bray, Jonathan Mill
BACKGROUND: Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic processes operating during this period have not been extensively explored. Of particular interest is DNA hydroxymethylation (5hmC), a modification that is enriched in the human brain and hypothesized to play an important role in neuronal function, learning and memory...
September 18, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28923013/pragmatic-clinical-trials-embedded-in-healthcare-systems-generalizable-lessons-from-the-nih-collaboratory
#12
Kevin P Weinfurt, Adrian F Hernandez, Gloria D Coronado, Lynn L DeBar, Laura M Dember, Beverly B Green, Patrick J Heagerty, Susan S Huang, Kathryn T James, Jeffrey G Jarvik, Eric B Larson, Vincent Mor, Richard Platt, Gary E Rosenthal, Edward J Septimus, Gregory E Simon, Karen L Staman, Jeremy Sugarman, Miguel Vazquez, Douglas Zatzick, Lesley H Curtis
BACKGROUND: The clinical research enterprise is not producing the evidence decision makers arguably need in a timely and cost effective manner; research currently involves the use of labor-intensive parallel systems that are separate from clinical care. The emergence of pragmatic clinical trials (PCTs) poses a possible solution: these large-scale trials are embedded within routine clinical care and often involve cluster randomization of hospitals, clinics, primary care providers, etc...
September 18, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28922928/differential-reinforcement-of-low-rate-schedules-reduce-severe-problem-behavior
#13
Andrew C Bonner, John C Borrero
Differential-reinforcement-of-low-rate (DRL) schedules are reinforcement contingencies designed to reduce response rates. A common variation of the DRL arrangement is known as full-session DRL ( f-DRL), in which a reinforcer is presented at the end of an interval if the response rate during that interval is below a predetermined criterion. Prior human operant research involving arbitrary mouse clicks has shown that the f-DRL is likely to reduce target responding to near zero rates. Similarly, applied research has shown that the f-DRL is likely to reduce minimally disruptive classroom behavior...
September 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/28922381/the-operation-of-a-research-and-development-r-d-program-and-its-significance-for-practice-change-in-community-pharmacy
#14
Andi Hermansyah, Erica Sainsbury, Ines Krass
BACKGROUND: Community pharmacy practice in Australia is changing and Research and Development (R&D) in community pharmacy plays an important role in contributing to the changes. A range of Cognitive Pharmacy Services (CPS) were developed from R&D programs, yet their implementation has been minimal indicating slow practice change within community pharmacy. Given the vital role of R&D, little is known about the operation and the extent to which it has been effective in supporting practice change in community pharmacy...
2017: PloS One
https://www.readbyqxmd.com/read/28922351/estimation-of-the-mechanical-properties-of-the-eye-through-the-study-of-its-vibrational-modes
#15
M Á Aloy, J E Adsuara, P Cerdá-Durán, M Obergaulinger, J J Esteve-Taboada, T Ferrer-Blasco, R Montés-Micó
Measuring the eye's mechanical properties in vivo and with minimally invasive techniques can be the key for individualized solutions to a number of eye pathologies. The development of such techniques largely relies on a computational modelling of the eyeball and, it optimally requires the synergic interplay between experimentation and numerical simulation. In Astrophysics and Geophysics the remote measurement of structural properties of the systems of their realm is performed on the basis of (helio-)seismic techniques...
2017: PloS One
https://www.readbyqxmd.com/read/28922282/the-grind-project-get-ready-to-initiate-a-nursing-degree
#16
Philisie Starling Washington
Numbers of students who declare a prenursing major and who enter a nursing program are vastly different. The GRIND (Get Ready to Initiate a Nursing Degree) research project, which operated for 3-week sessions from 2011 to 2015, exposed students to the nursing career through hospital tours and human simulation while instructing in study skills, dosage calculation, and standardized test preparation. Participants' understanding of nursing improved, and most felt at least somewhat to extremely prepared for nursing after participation...
September 15, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28922278/defining-the-critical-elements-for-the-most-common-procedures-in-spine-surgery-a-consensus-of-orthopaedic-and-neurosurgical-surgeons
#17
Joseph L Laratta, Samuel Cohen-Tanugi, Jamal N Shillingford, Joseph M Lombardi, Lawrence G Lenke, K Daniel Riew, Ronald A Lehman, Steven C Ludwig
STUDY DESIGN: Survey. OBJECTIVE: To define the critical elements of common spine surgeries. SUMMARY OF BACKGROUND DATA: Despite significant relevance to the field of spine surgery, the term "critical element" of surgery has not been clearly defined. Every surgical procedure involves numerous steps, each with its own potential for complications and harm to the patient. Despite its crucial role in surgical training, billing, and the ethicality of concurrent surgery, the term "critical element" of surgery has not been defined...
September 15, 2017: Spine
https://www.readbyqxmd.com/read/28921874/polaronic-charge-carrier-lattice-interaction-in-lead-halide-perovskites
#18
Christoph Wolf, Young-Hoon Kim, Himchan Cho, Tae-Woo Lee
Almost ten years after the renaissance of the popular perovskite-type semiconductors based on lead-salts with general formula AMX3 (A=organic or inorganic cation, M=divalent metal, X=halide), many facets of photophysics continue to puzzle researchers. In this review, we shed some light on the low mobilities of charge carriers in lead-halide perovskites with special focus on the lattice properties at non-zero temperature. The polar and soft lattice leads to pronounced electron-phonon coupling, limiting carrier mobility and retarding recombination...
September 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28921629/validation-of-prognostic-scores-to-predict-short-term-mortality-in-patients-with-acute-on-chronic-liver-failure
#19
Do Seon Song, Tae Yeob Kim, Dong Joon Kim, Hee Yeon Kim, Dong Hyun Sinn, Eileen L Yoon, Chang Wook Kim, Young Kul Jung, Ki Tae Suk, Sang Soo Lee, Chang Hyeong Lee, Tae Hun Kim, Won Hyeok Choe, Hyung Joon Yim, Sung Eun Kim, Soon Koo Baik, Jae Young Jang, Hyoung Su Kim, Sang Gyune Kim, Jin Mo Yang, Joo Hyun Sohn, Eun Hee Choi, Hyun Chin Cho, Soung Won Jeong, Moon Young Kim
BACKGROUND AND AIM: The aim of this study was to validate the Chronic Liver Failure-Sequential Organ Failure Assessment score (CLIF-SOFAs), CLIF consortium organ failure score (CLIF-C OFs), CLIF-C acute-on-chronic liver failure score (CLIF-C ACLFs), and CLIF-C acute decompensation score (CLIF-C ADs) in Korean chronic liver disease patients with acute deterioration. METHODS: ACLF was defined by either the Asian Pacific Association for the Study of the Liver ACLF Research Consortium (AARC) or CLIF-C criteria...
September 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28921401/experience-with-curative-radiotherapy-for-cervix-cancer-in-the-bahamas-for-2006-2016
#20
Glenn Jones, Osama Kellini, Nevein Girgis, Darron Halliday, Raleigh Butler, Thomas McGowan, Conville Brown
BACKGROUND: Cervix cancer is a significant health problem. As access to quality care in Small Island Developing States improves, and cancer centers become established, providers of care can summarize local experience to benchmark system quality and look for ways to further improve value. METHODS: This is a retrospective study of all cases of cervix cancer managed 2006-2016 at The Cancer Centre Bahamas, in conjunction with Princess Margaret Hospital, Nassau, affiliated with The University of West Indies...
September 18, 2017: Cancer Causes & Control: CCC
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