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https://www.readbyqxmd.com/read/28528022/direct-effect-of-curcumin-on-porcine-ovarian-cell-functions
#1
Attila Kádasi, Nora Maruniaková, Aneta Štochmaľová, Miroslav Bauer, Roland Grossmann, Abdel Halim Harrath, Adriana Kolesárová, Alexander V Sirotkin
Curcuma longa Linn (L.) is a plant widely used in cooking (in curry powder a.o.) and in folk medicine, but its action on reproductive processes and its possible mechanisms of action remain to be investigated. The objective of this study was to examine the direct effects of curcumin, the major Curcuma longa L. molecule, on basic ovarian cell functions such as proliferation, apoptosis, viability and steroidogenesis. Porcine ovarian granulosa cells were cultured with and without curcumin (at doses of 0, 1, 10 and 100μg/ml of medium)...
May 12, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28527659/curcumin-administration-suppress-acetylcholinesterase-gene-expression-in-cadmium-treated-rats
#2
Ayodele Jacob Akinyemi, Ganiyu Oboh, Adewale Oluwaseun Fadaka, Babawale Peter Olatunji, Seun Akomolafe
Curcumin, the main polyphenolic component of turmeric (Curcuma longa) rhizomes have been reported to exert anticholinesterase potential with limited information on how they regulate acetylcholinesterase (AChE) gene expression. Hence, this study sought to evaluate the effect of curcumin on cerebral cortex acetylcholinesterase (AChE) activity and their mRNA gene expression level in cadmium (Cd)-treated rats. Furthermore, in vitro effect of different concentrations of curcumin (1-5μg/mL) on rat cerebral cortex AChE activity was assessed...
May 17, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28516478/determination-of-oral-bioavailability-of-curcuminoid-dispersions-and-nanoemulsions-prepared-from-curcuma-longa-linnaeus
#3
P S Lu, B S Inbaraj, B H Chen
BACKGROUND: Curcuminoid from Curcuma longa Linnaeus has been demonstrated to be effective in anti-cancer and anti-inflammation. The objectives of this study were to prepare curcuminoid dispersion and nanoemulsion from C. longa and determine their oral bioavailability in rats. RESULTS: After curcuminoid extraction using 99.5% ethanol, bisdemethoxycurcumin (BDMC), demethoxycurcumin (DMC) and curcumin were separated within 10 min by HPLC with an Eclipse XDB-C18 column and a gradient mobile phase of 0...
May 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28505074/nafld-and-atherosclerosis-are-prevented-by-a-natural-dietary-supplement-containing-curcumin-silymarin-guggul-chlorogenic-acid-and-inulin-in-mice-fed-a-high-fat-diet
#4
Antonella Amato, Gaetano-Felice Caldara, Domenico Nuzzo, Sara Baldassano, Pasquale Picone, Manfredi Rizzo, Flavia Mulè, Marta Di Carlo
Non-alcoholic fatty liver disease (NAFLD) confers an increased risk of cardiovascular diseases. NAFDL is associated with atherogenic dyslipidemia, inflammation and renin-angiotensin system (RAS) imbalance, which in turn lead to atherosclerotic lesions. In the present study, the impact of a natural dietary supplement (NDS) containing Curcuma longa, silymarin, guggul, chlorogenic acid and inulin on NAFLD and atherosclerosis was evaluated, and the mechanism of action was examined. C57BL/6 mice were fed an HFD for 16 weeks; half of the mice were simultaneously treated with a daily oral administration (os) of the NDS...
May 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28503046/reflections-about-osteoarthritis-and-curcuma-longa
#5
REVIEW
Marina Cristina Akuri, Sandra Maria Barbalho, Raíssa Meira Val, Elen Landgraf Guiguer
Osteoarthritis (OA) is a chronic inflammatory degenerative process that affects joints such as the hands, hips, shoulders, feet, spine, and especially knees in millions of people worldwide. Some authors have shown that Curcuma longa components may exhibit benefic effects in the treatment of degenerative diseases as OA. This plant belongs to the family Zingiberaceae and it is popularly known as turmeric or saffron. This review intended to perform a retrospective search to identify studies involving humans and animal models...
January 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28501696/the-role-of-nitric-oxide-in-anticonvulsant-effect-of-nanocurcumine-on-pentylenetetrazole-induced-seizure-in-mice
#6
Alireza Aminirad, Seyyedeh Elaheh Mousavi, Nahid Fakhraei, Seyyedeh Mahbubeh Mousavi, Seyed Mahdi Rezayat
A plant alkaloid obtained from Curcuma longa, curcumin possesses anti-oxidant and anti-inflammatory effects. Nanoformulations have been developed for preclinical studies which demonstrate enhanced therapeutic efficacy. Effect of acute intraperitoneal (i.p.) administration of curcumin C3 complex nanoparticles [1,5, 10, 20, 40, 80mg/kg, (i.p.)] 75min prior to PTZ, on clonic seizure thresholds induced by intravenous infusion of pentylenetetrazole (PTZ) 0.5% was investigated in comparison with curcumin (40 and 80mg/kg, i...
May 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28500405/est-ssr-marker-revealed-effective-over-biochemical-and-morphological-scepticism-towards-identification-of-specific-turmeric-curcuma-longa-l-cultivars
#7
Ambika Sahoo, Sudipta Jena, Basudeba Kar, Suprava Sahoo, Asit Ray, Subhashree Singh, Raj Kumar Joshi, Laxmikanta Acharya, Sanghamitra Nayak
Turmeric (Curcuma longa L., family Zingiberaceae) is one of the most economically important plants for its use in food, medicine, and cosmetic industries. Cultivar identification is a major constraint in turmeric, owing to high degree of morphological similarity that in turn, affects its commercialization. The present study addresses this constraint, using EST-SSR marker based, molecular identification of 8 elite cultivars and 88 accessions in turmeric. Fifty EST-SSR primers were screened against eight cultivars of turmeric (Suroma, Roma, Lakadong, Megha, Alleppey Supreme, Kedaram, Pratibha, and Suvarna); out of which 11 primers showed polymorphic banding pattern...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28499256/from-common-to-rare-zingiberaceae-plants-a-metabolomics-study-using-gc-ms
#8
Gina B Barbosa, Nirupama S Jayasinghe, Siria H A Natera, Ellen D Inutan, Nonita P Peteros, Ute Roessner
Zingiberaceae plants, commonly known as gingers, have been popular for their medicinal and culinary uses since time immemorial. In spite of their numerous health-promoting applications, many Zingiberaceae plants still receive no scientific attention. Moreover, existing reports mostly focused only on the Zingiberaceae rhizomes. Here, untargeted metabolite profiling using Gas Chromatography - Mass Spectrometry (GC-MS) was used to compare the metabolic composition of leaves and rhizomes of the more common gingers, Zingiber officinale Rosc...
May 9, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28487811/curcumin-inhibits-nthi-induced-muc5ac-mucin-overproduction-in-otitis-media-via-upregulation-of-mapk-phosphatase-mkp-1
#9
Anuhya Sharma Konduru, Shingo Matsuyama, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third of episodes of bacteria-caused OM. Current treatments for bacterial OM rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. Therefore there is an urgent need for developing alternative therapies strategies for controlling mucus overproduction in OM...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28482898/ethnopharmacological-survey-of-medicinal-plants-practiced-by-traditional-healers-and-herbalists-for-treatment-of-some-urological-diseases-in-the-west-bank-palestine
#10
Nidal Amin Jaradat, Abdel Naser Zaid, Rowa Al-Ramahi, Malik A Alqub, Fatima Hussein, Zakaria Hamdan, Mahmoud Mustafa, Mohammad Qneibi, Iyad Ali
BACKGROUND: Throughout history, every civilization in the world used plants or their derivatives for treatment or prevention of diseases. In Palestine as in many other countries, herbal medicines are broadly used in the treatment of wide range of diseases including urological diseases. The main objective of this research is to study the use of herbal remedies by herbalists and traditional healers for treatment of various urological diseases in the West Bank regions of Palestine and to assess their efficacy and safety through the literature review of the most cited plants...
May 8, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28443468/curcumin-increases-the-sensitivity-of-paclitaxel-resistant-nsclc-cells-to-paclitaxel-through-microrna-30c-mediated-mta1-reduction
#11
Yimin Lu, Jun Wang, Lei Liu, Lequn Yu, Nian Zhao, Xingju Zhou, Xudong Lu
Non-small-cell lung cancer is one of the most lethal cancers in the worldwide. Although Paclitaxel-based combinational therapies have long been used as a standard treatment in aggressive non-small-cell lung cancers, Paclitaxel resistance emerges as a major clinical problem. It has been demonstrated that Curcumin from Curcuma longa as a traditional Chinese medicine can inhibit cancer cell proliferation. However, the role of Curcumin in Paclitaxel-resistant non-small-cell lung cancer cells is not clear. In this study, we investigated the effect of Curcumin on the Paclitaxel-resistant non-small-cell lung cancer cells and found that Curcumin treatment markedly increased the sensitivity of Paclitaxel-resistant non-small-cell lung cancer cells to Paclitaxel...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28440093/turmeric-curcuma-longa-l-extract-may-prevent-the-deterioration-of-spatial-memory-and-the-deficit-of-estimated-total-number-of-hippocampal-pyramidal-cells-of-trimethyltin-exposed-rats
#12
Sapto Yuliani, Mustofa, Ginus Partadiredja
CONTEXT: Protection of neurons from degeneration is an important preventive strategy for dementia. Much of the dementia pathology implicates oxidative stress pathways. Turmeric (Curcuma longa L.) contains curcuminoids which has anti-oxidative and neuro-protective effects. These effects are considered to be similar to those of citicoline which has been regularly used as one of standard medications for dementia. OBJECTIVE: This study aimed at investigating the effects of turmeric rhizome extract on the hippocampus of trimethyltin (TMT)-treated Sprague-Dawley rats...
April 25, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28439402/upregulation-of-heme-oxygenase-1-expression-by-curcumin-conferring-protection-from-hydrogen-peroxide-induced-apoptosis-in-h9c2-cardiomyoblasts
#13
Xiaobo Yang, Hong Jiang, Yao Shi
BACKGROUND: Curcumin is a major constituent of rhizomes of Curcuma longa that elicits beneficial effects for oxidative damage. The aim of this study was to investigate whether curcumin could attenuate hydrogen peroxide (H2O2)-induced apoptosis in H9c2 cardiomyoblasts and the underlying mechanisms. RESULTS: The present study showed that exposure of H9c2 cells to H2O2 caused a significant increase in apoptosis as evaluated by flow cytometry analysis and the pretreatment of curcumin protected against H2O2-induced apoptosis...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/28435333/new-insights-into-therapeutic-activity-and-anticancer-properties-of-curcumin
#14
REVIEW
Abir Kumar Panda, Dwaipayan Chakraborty, Irene Sarkar, Tila Khan, Gaurisankar Sa
Natural compounds obtained from plants are capable of garnering considerable attention from the scientific community, primarily due to their ability to check and prevent the onset and progress of cancer. These natural compounds are primarily used due to their nontoxic nature and the fewer side effects they cause compared to chemotherapeutic drugs. Furthermore, such natural products perform even better when given as an adjuvant along with traditional chemotherapeutic drugs, thereby enhancing the potential of chemotherapeutics and simultaneously reducing their undesired side effects...
2017: Journal of Experimental Pharmacology
https://www.readbyqxmd.com/read/28406873/investigation-of-the-anxiolytic-and-antidepressant-effects-of-curcumin-a-compound-from-turmeric-curcuma-longa-in-the-adult-male-sprague-dawley-rat
#15
Tomás Eduardo Ceremuga, Katie Helmrick, Zachary Kufahl, Jesse Kelley, Brian Keller, Fabiola Philippe, James Golder, Gina Padrón
As the use of herbal medications continues to increase in America, the potential interaction between herbal and prescription medications necessitates the discovery of their mechanisms of action. The purpose of this study was to investigate the anxiolytic and antidepressant effects of curcumin, a compound from turmeric (Curcuma longa), and its effects on the benzodiazepine site of the γ-aminobutyric acid receptor A (GABAA) receptor. Utilizing a prospective, between-subjects group design, 55 male Sprague-Dawley rats were randomly assigned to 1 of the 5 intraperitoneally injected treatment groups: vehicle, curcumin, curcumin + flumazenil, midazolam, and midazolam + curcumin...
May 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/28403342/tissue-sulfomucin-and-sialomucin-content-in-colon-mucosa-without-intestinal-transit-subjected-to-intervention-with-curcuma-longa-curcumin
#16
Antonio José Tiburcio Alves, José Aires Pereira, Adrieli Heloísa Campardo Pansani, Daniela Oliveira Magro, Cláudio Saddy Rodrigues Coy, Carlos Augusto Real Martinez
Purpose: To measure the tissue sulfomucin and sialomucin content of the colon mucosa without fecal flow, subjected to intervention with curcumin, and the influence of the concentration used and the intervention time. Methods: Thirty-six rats were subjected to proximal right colostomy and distal mucous fistula. They were divided into two groups according to whether sacrifice was performed two or four weeks after the intervention. Each group was divided into three subgroups according to the enema applied daily: saline alone; curcumin at 50 mg/kg/day or curcumin at 200 mg/kg/day...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28401758/curcuminoid-demethylation-as-an-alternative-metabolism-by-human-intestinal-microbiota
#17
Supawadee Burapan, Mihyang Kim, Jaehong Han
Curcumin and other curcuminoids from Curcuma longa are important bioactive compounds exhibiting various pharmacological activities. In addition to the known reductive metabolism of curcuminoids, an alternative biotransformation of curcuminoids by human gut microbiota is reported herein. A curcuminoid mixture, composed of curcumin (1), demethoxycurcumin (2), and bisdemethoxycurcumin (3), was metabolized by the human intestinal bacterium Blautia sp. MRG-PMF1. 1 and 2 were converted to new metabolites by the methyl aryl ether cleavage reaction...
April 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28394628/an-overview-of-structure-activity-relationship-studies-of-curcumin-analogs-as-antioxidant-and-anti-inflammatory-agents
#18
Laiba Arshad, Md Areeful Haque, Syed Nasir Abbas Bukhari, Ibrahim Jantan
Curcumin, extracted mainly from Curcuma longa rhizomes, has been reported to possess potent anti-inflammatory and anti-oxidant activities. Although safe at higher doses and exhibiting multiple biological activities, curcumin still has the problem of poor bioavailability which has been an attractive area of research over the last few years. A number of efforts have been made by modifying structural features of curcumin. This review highlights the structurally modified and more stable newly synthesized curcumin analogs that have been screened against antioxidant and anti-inflammatory activities...
April 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28386462/norfloxacin-and-metronidazole-topical-formulations-for-effective-treatment-of-bacterial-infections-and-burn-wounds
#19
REVIEW
Kamal Dua, Venkata Ramana Malipeddi, Jyotsna Madan, Gaurav Gupta, Srikumar Chakravarthi, Rajendra Awasthi, Irene Satiko Kikuchi, Terezinha De Jesus Andreoli Pinto
INTRODUCTION: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems. AIMS AND METHODS: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds...
June 1, 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28368746/continuous-production-of-aqueous-suspensions-of-ultra-fine-particles-of-curcumin-using-ultrasonically-driven-mixing-device
#20
Komal Pandey, Amruta Chatte, Sameer Dalvi
Developing drug formulations for poorly water-soluble drugs is a major challenge for pharmaceutical industries as the poor water solubility limits bioavailability of these drugs. Production of nanoparticles/microparticles of these drugs is one of the ways to improve dissolution rates by increasing interfacial area for dissolution. Curcumin, a compound obtained from the rhizome of curcuma longa (turmeric roots), is a pharmaceutically viable molecule. However, poor aqueous solubility limits its therapeutic use...
April 24, 2017: Pharmaceutical Development and Technology
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