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curcuma longa

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https://www.readbyqxmd.com/read/29341943/beneficial-effect-of-chronic-treatment-with-extracts-from-rhodiola-rosea-l-and-curcuma-longa-l-on-the-immunoreactivity-of-animals-subjected-to-a-chronic-mild-stress-model
#1
Liliya V Vasileva, Kremena Е Saracheva, Mariya V Ivanovska, Atanaska P Petrova, Emir Sucouglu, Mariana A Murdjeva, Damyanka P Getova-Spasova
BACKGROUND: Recent studies have suggested increased levels of pro-inflammatory cytokines in depression. AIM: The present study aimed to evaluate the effect of extracts from Rhodiola and Curcuma on immunoreactivity of animals subjected to a chronic mild stress (CMS) model followed by lipopolysaccharide-induced inflammation. MATERIALS AND METHODS: Male Wistar rats (n=56) divided in 7 groups were treated orally with: distilled water 10 ml/kg (control and CMS model groups); Rhodiola 250 mg/kg; Rhodiola 500 mg/kg; Curcuma 250 mg/kg; Curcuma 500 mg/kg, Rhodiola 250 mg/kg and Curcuma 250 mg/kg...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29338678/supplementation-with-curcuma-longa-reverses-neurotoxic-and-behavioral-damage-in-models-of-alzheimer-s-disease-a-systematic-review
#2
Ianara Mendonca da Costa, Marco Aurelio de Moura Freire, Jose Rodolfo Lopes de Paiva Cavalcanti, Dayane Pessoa de Araujo, Bianca Norrara, Isleania Maria Marques Moreira Rosa, Eduardo Pereira de Azevedo, Amalia Cinthia Meneses do Rego, Irami Araujo Filho, Fausto Pierdona Guzen
BACKGROUND: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases...
January 16, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29336271/anti-inflammatory-drugs-and-herbs-with-special-emphasis-on-herbal-medicines-for-countering-inflammatory-diseases-and-disorders-a-review
#3
Mohd Iqbal Yatoo, Arumugam Gopalakrishnan, Archana Saxena, Oveas Rafiq Parray, Noore Alam Tufani, Sandip Chakraborty, Ruchi Tiwari, Kuldeep Dhama, Hafiz M N Iqbal
BACKGROUND: Diseases with inflammatory etiopathology have increased in incidence in recent times. Drugs used for therapeutic management of such inflammatory diseases are relieving the ailment but at the same time also countering serious life-threatening consequences. Moreover, they are costly and rarely available at all places. In this context, research and development on medicinal herbs have opened a new era in the prophylactic and therapeutic management of inflammatory diseases. OBJECTIVE: To highlight the importance of anti-inflammatory medicine-synthetic drugs and natural herbs, their constituents, mechanism of action, benefits, side effects and future prospects...
January 15, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29318975/evaluation-of-the-antiproliferative-activity-of-some-nanoparticulate-essential-oils-formulated-in-microemulsion-on-selected-human-carcinoma-cell-lines
#4
Ahmed Abd-Rabou, Amr E Edris
BACKGROUND: Essential oils (EOs) are natural volatile plant extract that have different biological activities including antiproliferative potentials. OBJECTIVE: the current study aims at evaluating the antiproliferative activities of six EOs in their neat state compared to their nanoparticulate form after fabrication in microemulsion against some cancer cell lines. The EOs included marjoram (Origanum majorana), turmeric (Curcuma longa), sweet basil (Ocimum basillicum), clove buds (Syzygium aromaticum), geranium (plargonium graviolenis), and black cumin (Nigella sativa)...
January 10, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29317884/evaluation-of-the-anti-schistosomal-effects-of-turmeric-curcuma-longa-versus-praziquantel-in-schistosoma-mansoni-infected-mice
#5
Atef Hussein, Samia Rashed, Ibrahim El Hayawan, Rabab El-Sayed, Hemat Ali
Background: Curcumin is the major active ingredient of Curcuma longa L., traditionally known as turmeric and has been shown to exhibit a wide range of pharmacological activities including anti-parasitic effect. However, it is found to be water-insoluble and has low bioavailability. The aim of this study was to explore the potential role of turmeric solved in olive oil either alone or in combination with praziquantel (PZQ) in treatment of schistosomiasis mansoni. Methods: The whole turmeric powder suspended in olive oil (as a solvent) is indicated to S...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29316908/efficacy-and-safety-of-curcumin-and-its-combination-with-boswellic-acid-in-osteoarthritis-a-comparative-randomized-double-blind-placebo-controlled-study
#6
Armine Haroyan, Vahan Mukuchyan, Nana Mkrtchyan, Naira Minasyan, Srbuhi Gasparyan, Aida Sargsyan, Mikael Narimanyan, Areg Hovhannisyan
BACKGROUND: The aim of this clinical trial was to assess the efficacy and safety of curcuminoid complex extract from turmeric rhizome with turmeric volatile oil (CuraMed®) and its combination with boswellic acid extract from Indian frankincense root (Curamin®) vs placebo for the treatment of 40- to 70-year-old patients with osteoarthritis (OA). METHODS: The effects of CuraMed® 500-mg capsules (333 mg curcuminoids) and Curamin® 500-mg capsules (350 mg curcuminoids and 150 mg boswellic acid) taken orally three times a day for 12 weeks in 201 patients was investigated in a three-arm, parallel-group, randomized, double-blinded, placebo-controlled trial...
January 9, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29313174/polar-extract-of-curcuma-longa-protects-cartilage-homeostasis-possible-mechanism-of-action
#7
Chandrasekaran Chinampudur Velusami, Edwin Jothie Richard, Bharathi Bethapudi
BACKGROUND: Curcuma longa has been well documented for managing joint inflammation and pain. The present study investigated the effect of polar extract of C. longa (NR-INF-02) on cartilage homeostasis in human articular chondrocytes knee (NHAC-kn) cells to understand its plausible mechanism of action. METHODS: Dysregulation of cartilage homeostasis was induced by IL-1β and H2O2. Modulating effects of NR-INF-02 on degradation markers viz., chondrocyte apoptosis, senescence, cytokine, eicosanoids, and cartilage synthesis markers viz...
January 8, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29301315/protective-and-detoxifying-effects-conferred-by-dietary-selenium-and-curcumin-against-afb1-mediated-toxicity-in-livestock-a-review
#8
REVIEW
Aniket Limaye, Roch-Chui Yu, Cheng-Chun Chou, Je-Ruei Liu, Kuan-Chen Cheng
Aflatoxin B1 (AFB1), among other aflatoxins of the aflatoxin family, is the most carcinogenic and hazardous mycotoxin to animals and human beings with very high potency leading to aflatoxicosis. Selenium is an essential trace mineral possessing powerful antioxidant functions. Selenium is widely reported as an effective antioxidant against aflatoxicosis. By preventing oxidative liver damage, suppressing pro-apoptotic proteins and improving immune status in AFB1 affected animals; selenium confers specific protection against AFB1 toxicity...
January 2, 2018: Toxins
https://www.readbyqxmd.com/read/29300102/curcumin-and-melanoma-from-chemistry-to-medicine
#9
Seyed Mohammad Nabavi, Gian Luigi Russo, Idolo Tedesco, Maria Daglia, Ilkay Erdogan Orhan, Seyed Fazel Nabavi, Anupam Bishayee, Kalyan C Nagulapalli Venkata, Mohammad Abdollahi, Zohreh Hajheydari
Melanoma is the most deadly form of skin cancer, with about 48,000 deaths each year worldwide. Growing evidence suggests that individual nutrients or dietary patterns might have important roles in the prevention of melanoma. Considering that melanoma is a potentially life-threatening cancer, novel protective and adjuvant treatments are needed to improve its prognosis. Curcumin is a bioactive substance extracted from rhizome of Curcuma longa L. Its global market is expected to grow in the next few years, especially in the pharmaceutical industry, due to its numerous physiological and pharmacological properties...
January 4, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29291086/curcumin-improves-glycolipid-metabolism-through-regulating-peroxisome-proliferator-activated-receptor-%C3%AE-signalling-pathway-in-high-fat-diet-induced-obese-mice-and-3t3-l1-adipocytes
#10
Yanyun Pan, Dandan Zhao, Na Yu, Tian An, Jianan Miao, Fangfang Mo, Yujie Gu, Dongwei Zhang, Sihua Gao, Guangjian Jiang
Curcumin is an active component derived from Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathways. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6 J obese mice and 3T3-L1 adipocytes were used for in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for eight weeks decreased body weight, fat mass and serum lipid profiles...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29283372/neuroprotective-effects-and-mechanisms-of-curcumin-cu-ii-and-zn-ii-complexes-systems-and-their-pharmacological-implications
#11
Fa-Shun Yan, Jian-Long Sun, Wen-Hai Xie, Liang Shen, Hong-Fang Ji
Alzheimer's disease (AD) is the main form of dementia and has a steadily increasing prevalence. As both oxidative stress and metal homeostasis are involved in the pathogenesis of AD, it would be interesting to develop a dual function agent, targeting the two factors. Curcumin, a natural compound isolated from the rhizome of Curcuma longa, is an antioxidant and can also chelate metal ions. Whether the complexes of curcumin with metal ions possess neuroprotective effects has not been evaluated. Therefore, the present study was designed to investigate the protective effects of the complexes of curcumin with Cu(II) or Zn(II) on hydrogen peroxide (H₂O₂)-induced injury and the underlying molecular mechanisms...
December 28, 2017: Nutrients
https://www.readbyqxmd.com/read/29278024/curcumin-regulates-intracellular-calcium-release-and-inhibits-oxidative-stress-parameters-vegf-and-caspase-3-9-levels-in-human-retinal-pigment-epithelium-cells
#12
H Bardak, A C Uğuz, Y Bardak
In this study, we aimed to observe whether curcumin (cur), a polyphenolic compound derived from the dietary spice turmeric, a yellow substance obtained from the root of the plant Curcuma longa Linn, has any protective effect against blue light irradiation in human retinal pigment epithelium (ARPE-19) cells. For this purpose, we evaluated the intracellular calcium release mechanism, poly ADP ribose polymerase (PARP), procaspase-3/-9 protein expression levels, caspase activation, and reactive oxygen species levels...
December 1, 2017: Physiology International
https://www.readbyqxmd.com/read/29258259/regulation-of-polyamine-metabolism-by-curcumin-for-cancer-prevention-and-therapy
#13
REVIEW
Tracy Murray-Stewart, Robert A Casero
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric (Curcuma longa), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues...
December 18, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29243674/turmeric-a-condiment-cosmetic-and-cure
#14
REVIEW
Hima Gopinath, Kaliaperumal Karthikeyan
Turmeric (Curcuma longa L.) is an integral part of Asian culture and cuisine. It has been used in traditional medicine since centuries. A myriad of health benefits have been attributed to it. Curcumin, the most biologically active curcuminoid in turmeric, is being investigated in pre-clinical and clinical trials for its role in disease prevention and cure. It has antioxidant, anti-inflammatory, antineoplastic, anti-proliferative and antimicrobial effects. We review the chemistry of this plant, its cultural relevance in Indian skin care, and its uses in dermatology...
January 2018: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29243061/neuroprotective-effect-of-curcumin-against-cerebral-ischemia-reperfusion-via-mediating-autophagy-and-inflammation
#15
Lifa Huang, Chengwei Chen, Xin Zhang, Xu Li, Zupeng Chen, Chao Yang, Xiaolong Liang, Guochong Zhu, Zhen Xu
Curcumin, a polyphenolic compound extracted from Curcuma longa, has drawn attention for its effective bioactivities against ischemia-induced injury. This study aimed to evaluate the neuroprotective effect of curcumin and investigate the underlying mechanism that mediates autophagy and inflammation in an animal model of middle cerebral artery occlusion (MCAO) in rats. Curcumin was delivered to Sprague Dawley male rats at a dose of 200 mg/kg curcumin by intraperitoneal injection 30 min after ischemia-reperfusion (I/R)...
December 15, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29242172/curcumin-enhances-lxr%C3%AE-in-an-amp-activated-protein-kinase-dependent-manner-in-human-macrophages
#16
Javier Sáenz, Gonzalo Alba, María E Reyes-Quiroz, Isabel Geniz, Juan Jiménez, Francisco Sobrino, Consuelo Santa-María
Liver X receptor alpha (LXRα) is a nuclear receptor involved in cholesterol homeostasis. Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa and a well-known AMP-activated protein kinase (AMPK) activator, possess hypocholesterolemic activity, however, the possible link between AMPK and cholesterol is unknown. In this study, we have investigated whether curcumin regulates metabolic changes in cholesterol metabolism via LXRα in THP-1 human macrophages, the cells implicated in atheroma plaques formation...
November 16, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29241692/in%C3%A2-vitro-inhibitory-effects-of-major-bioactive-constituents-of-andrographis-paniculata-curcuma-longa-and-silybum-marianum-on-human-liver-microsomal-morphine-glucuronidation-a-prediction-of%C3%A2-potential-herb-drug-interactions-arising-from-andrographolide-curcumin
#17
Verawan Uchaipichat
This study aimed to investigate the liver microsomal inhibitory effects of silybin, silychristin, andrographolide, and curcumin by using morphine as an in vitro UGT2B7 probe substrate, and predict the magnitude of the herb-drug interaction arising from these herbal constituents' inhibition in vivo. Studies were performed in the incubation with and without bovine serum albumin (BSA). Andrographolide and curcumin showed a marked inhibition on morphine 3- and 6-glucuronidation with IC50 of 50&87 and 96&111 μM, respectively...
November 20, 2017: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29234397/artemisia-iwayomogi-plus-curcuma-longa-synergistically-ameliorates-nonalcoholic-steatohepatitis-in-hepg2-cells
#18
Hyeong-Geug Kim, Sung-Bae Lee, Jin-Seok Lee, Won-Young Kim, Seung-Hoon Choi, Chang-Gue Son
The combination of Artemisia iwayomogi and Curcuma longa radix is frequently prescribed for liver diseases in TKM. However, the synergic effects of the two herbs on nonalcoholic steatohepatitis (NASH) have not yet been studied. Therefore, we investigated the anti-NASH effects of the water extract of A. iwayomogi (AI), C. longa radix (CL), and combination of the two herbs (ACE). Hepatic steatosis and NASH were induced in HepG2 cells by treatment with palmitic acid (PA, for 6 h) with/without pretreatment of ACE (25 or 50 μg/mL), AI (50 or 100 μg/mL), CL (50 or 100 μg/mL), curcumin (5 μg/mL), or scopoletin (5 μg/mL)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232190/the-effects-of-curcuma-longa-and-curcumin-on-reproductive-systems
#19
R Mohebbati, A Anaeigoudari, M R Khazdair
OBJECTIVE: Curcuma longa (C. longa) was used in some countries such as China and India for various medicinal purposes. Curcumin, the active component of C. longa, is commonly used as a coloring agent in foods, drugs, and cosmetics. C. longa and curcumin have been known to act as antioxidant, anti-inflammatory, anti-mutagen, and anti-carcinogenic agents. Th e attempt of the present review was to give an effort on a detailed literature survey concentrated on the protective effects of C...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29229242/synthesis-characterisation-and-biomedical-applications-of-curcumin-conjugated-chitosan-microspheres
#20
T S Saranya, V K Rajan, Raja Biswas, R Jayakumar, S Sathianarayanan
Curcumin is a diaryl heptanoid of curcuminoids class obtained from Curcuma longa. It possesses various biological activities like anti-inflammatory, hypoglycemic, antioxidant, wound-healing, and antimicrobial activities. Chitosan is a biocompatible, biodegradable and non-toxic natural polymer which enhances the adhesive property of the skin. Chemical conjugation will leads to sustained release action and to enhance the bioavailability. This study aims to synthesis and characterize biocompatible curcumin conjugated chitosan microspheres for bio-medical applications...
December 8, 2017: International Journal of Biological Macromolecules
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