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https://www.readbyqxmd.com/read/29773013/critical-review-on-curcumin-as-a-therapeutic-agent-from-traditional-herbal-medicine-to-an-ideal-therapeutic-agent
#1
Muhammad Usman Akbar, Kanwal Rehman, Khalid Mahmood Zia, Muhammad Imran Qadir, Muhammad Sajid Hamid Akash, Muhammad Ibrahim
Traditionally, many natural medicinal plants have been used to treat a variety of diseases since ancient times and are considered a potential source of phytochemicals for the development of new drugs. One of these is curcumin, which is an easily accessible, inexpensive, and nontoxic bioactive compound. Curcumin is a very important, naturally occurring, and highly lipophilic and phenolic substance derived from the rhizomes of plant Curcuma longa, a member of the Zingiberaceae (ginger) family, which is mostly used as a curry spice, flavoring agent, insect repellent, coloring agent in food, traditional drug, and ingredient in cosmetics...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29752960/assessment-of-herb-drug-synergy-to-combat-doxorubicin-induced-cardiotoxicity
#2
Aditi Jain, Vibha Rani
Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potential in this regard. Curcuma longa (an Indian herb) polyphenols including curcumin, and well known for its anti-oxidative and anti-cancerous potential was used in the present study for its synergistic effect on cancer cells and cardiomyocytes...
May 9, 2018: Life Sciences
https://www.readbyqxmd.com/read/29743988/molecular-mechanisms-underlying-curcumin-mediated-therapeutic-effects-in-type-2-diabetes-and-cancer
#3
REVIEW
Marzena Wojcik, Michal Krawczyk, Pawel Wojcik, Katarzyna Cypryk, Lucyna Alicja Wozniak
The growing prevalence of age-related diseases, especially type 2 diabetes mellitus (T2DM) and cancer, has become global health and economic problems. Due to multifactorial nature of both diseases, their pathophysiology is not completely understood so far. Compelling evidence indicates that increased oxidative stress, resulting from an imbalance between production of reactive oxygen species (ROS) and their clearance by antioxidant defense mechanisms, as well as the proinflammatory state contributes to the development and progression of the diseases...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29732511/protective-effects-of-curcuma-longa-against-neurobehavioral-and-neurochemical-damage-caused-by-cerium-chloride-in-mice
#4
Yamina Kadri, Riadh Nciri, Noura Brahmi, Saber Saidi, Abdel Halim Harrath, Saleh Alwasel, Waleed Aldahmash, Abdelfatteh El Feki, Mohamed Salah Allagui
Cerium chloride (CeCl3 ) is considered an environmental pollutant and a potent neurotoxic agent. Medicinal plants have many bioactive compounds that provide protection against damage caused by such pollutants. Curcuma longa is a bioactive compound-rich plant with very important antioxidant properties. To study the preventive and healing effects of Curcuma longa on cerium-damaged mouse brains, we intraperitoneally injected cerium chloride (CeCl3 , 20 mg/kg BW) along with Curcuma longa extract, administrated by gavage (100 mg/kg BW), into mice for 60 days...
May 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29723631/paraptosis-in-human-glioblastoma-cell-line-induced-by-curcumin
#5
Monika Garrido-Armas, Juan Carlos Corona, Maria Luisa Escobar, Leda Torres, Francisco Ordóñez-Romero, Abrahan Hernández-Hernández, Francisco Arenas-Huertero
Curcumin is a polyphenol compound extracted from Curcuma longa plant, is a molecule with pleiotropic effects that suppresses transformation, proliferation and metastasis of malignant tumors. Curcumin can cause different kinds of cell death depending of its concentration on the exposed cell type. Here we show that exposure of the glioblastoma cell line A172 to curcumin at 50 μM, the IC50, causes morphological changes characteristic of paraptosis cell-death. Vesicles derived from the ER and low membrane potential of the mitochondria were constantly found in the exposed cells...
April 30, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29720822/herbal-medicines-showing-synergistic-effects-with-tumor-necrosis-factor-related-apoptosis-inducing-ligand-trail-against-a549-trail-resistant-lung-cancer-cells-a-screening-study
#6
Shuen Cheng Chiang, Yeon-Jung Choi, Shi-Eun Kang, Miyong Yun, Beom-Joon Lee
Background: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that activates apoptosis through death receptors on the cell surface and is regarded as a potential anticancer agent. However, many cancer cells are resistant to TRAIL-induced apoptosis. Objective: The aim is to identify the herbal medicines that could help overcome resistance in TRAIL-resistant lung cancer cells. Materials and Methods: TRAIL-resistant A549 cells and 13 herbal medicines with known apoptosis-related anticancer effects were used in this study: Clematidis Radix , Corydalis Tuber Rhizoma , Paeoniae Radix Rubra , Corni Fructus , Curcumae longae Rhizoma (CLR) , Moutan Cortex , Salviae miltiorrhizae Radix , Phellodendri Cortex , Farfarae Flos , Paeoniae Radix Alba , Angelicae gigantis Radix , Coptidis Rhizoma (CR), and Taraxaci Herba ...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29710047/chemical-constituents-and-bioactivities-of-several-indonesian-plants-typically-used-in-jamu
#7
Retno Widyowati, Mangestuti Agil
This article reviews the chemical constituents and bioactivities of several Indonesian plants typically used in Jamu prescriptions in Indonesia. Jamu is Indonesia traditional medicine: it consists of either a single ingredient or a mixture of several medicinal plants. One plant family always used in Jamu is Zingiberaceae (ginger), such as Curcuma domestica/C. longa, C. xanthorrhizae, C. heyneana, C. zedoaria, C. aeruginosa, Zingiber aromaticum, Alpinia galanga. We also report other commonly used plant families such as Justicia gendarussa and Cassia siamea, whose activities have been extensively explored by our department...
2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29709646/cytotoxicity-of-18-cameroonian-medicinal-plants-against-drug-sensitive-and-multi-factorial-drug-resistant-cancer-cells
#8
Armelle T Mbaveng, Hermione T Manekeng, Gaelle S Nguenang, Joachim K Dzotam, Victor Kuete, Thomas Efferth
ETHNOPHARMACOLOGICAL RELEVANCE: Recommendations have been made stating that ethnopharmacological usages such as immune and skin disorders, inflammatory, infectious, parasitic and viral diseases should be taken into account if selecting plants for anticancer screening, since these reflect disease states bearing relevance to cancer or cancer-like symptoms. Cameroonian medicinal plants investigated in this work are traditionally used to treat cancer or ailments with relevance to cancer or cancer-like symptoms...
April 27, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29708818/a-placebo-controlled-double-blind-study-demonstrates-the-clinical-efficacy-of-a-novel-herbal-formulation-for-relieving-joint-discomfort-in-human-subjects-with-osteoarthritis-of-knee
#9
Vasu Karlapudi, Anjaneya Venkata Vara Prasad Mungara, Krishanu Sengupta, Barbara A Davis, Siba Prasad Raychaudhuri
LI73014F2 is a novel composition prepared from extracts of Terminalia chebula fruit, Curcuma longa rhizome, and Boswellia serrata gum resin with synergistic benefit in 5-Lipoxygenase (5-LOX) inhibition. This herbal composition with strong anti-5-LOX activity exhibited significant pain relief as indicated through improvements in weight-bearing capacity in a monosodium iodoacetate-induced osteoarthritis (OA) model of Sprague-Dawley rats. A 90-day randomized, placebo-controlled double-blind study evaluates the clinical efficacy and tolerability of LI73014F2 in the management of symptoms of OA of the knee (Clinical Trial Registration No...
April 30, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29703390/concurrent-administration-of-anticancer-chemotherapy-drug-and-herbal-medicine-on-the-perspective-of-pharmacokinetics
#10
REVIEW
Yung-Yi Cheng, Chen-Hsi Hsieh, Tung-Hu Tsai
With an increasing number of cancer patients seeking an improved quality of life, complementary and alternative therapies are becoming more common ways to achieve such improvements. The potential risks of concurrent administration are serious and must be addressed. However, comprehensive evidence for the risks and benefits of combining anticancer drugs with traditional herbs is rare. Pharmacokinetic investigations are an efficient way to understand the influence of concomitant remedies. Therefore, this study aimed to collect the results of pharmacokinetic studies relating to the concurrent use of cancer chemotherapy and complementary and alternative therapies...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29686295/curcumin-interacts-directly-with-the-cysteine-259-residue-of-stat3-and-induces-apoptosis-in-h-ras-transformed-human-mammary-epithelial-cells
#11
Young-Il Hahn, Su-Jung Kim, Bu-Young Choi, Kyung-Cho Cho, Raju Bandu, Kwang Pyo Kim, Do-Hee Kim, Wonki Kim, Joon Sung Park, Byung Woo Han, Jeewoo Lee, Hye-Kyung Na, Young-Nam Cha, Young-Joon Surh
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that is latent but constitutively activated in many types of cancers. It is well known that STAT3 plays a key role in inflammation-associated tumorigenesis. Curcumin is an anti-inflammatory natural compound isolated from the turmeric (Curcuma longa L., Zingiberaceae) that has been extensively used in a traditional medicine over the centuries. In the present study, we have found that curcumin inhibits STAT3 signaling that is persistently overactivated in H-Ras transformed breast epithelial cells (H-Ras MCF10A)...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679204/efficacy-of-curcumin-for-age-associated-cognitive-decline-a-narrative-review-of-preclinical-and-clinical-studies
#12
REVIEW
Marjana Rahman Sarker, Susan F Franks
Processes such as aberrant redox signaling and chronic low-grade systemic inflammation have been reported to modulate age-associated pathologies such as cognitive impairment. Curcumin, the primary therapeutic component of the Indian spice, Turmeric (Curcuma longa), has long been known for its strong anti-inflammatory and antioxidant activity attributable to its unique molecular structure. Recently, an interest in this polyphenol as a cognitive therapeutic for the elderly has emerged. The purpose of this paper is to critically review preclinical and clinical studies that have evaluated the efficacy of curcumin in ameliorating and preventing age-associated cognitive decline and address the translational progress of preclinical to clinical efficacy...
April 21, 2018: GeroScience
https://www.readbyqxmd.com/read/29676082/-research-on-standard-decoction-of-processed-curcumae-longae-rhizoma-containing-volatile-oil
#13
Zhe Deng, Fan Zhang, Meng-Jiao Jiao, Jun Zhang, Jia Shi, Jin-Tang Cheng, An Liu
To prepare processed Curcumae Longae Rhizoma standard decoction, establish its quality standard, provides quality reference for formulated Jianghuang granules and lay a foundation for standard decoction research for the pieces containing volatile oil. Thirteen batches of processed Curcumae Longae Rhizoma standard decoctions were prepared according to the preparation requirements for standard decoction of Chinese herbal medicine containing volatile oil. With curcumin as the detection index, the transfer rate and extraction ratio were calculated; the pH value was determined and HPLC fingerprint analysis method was established...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29662734/effect-of-a-water-extract-of-curcuma-longa-on-emotional-states-in-healthy-participants
#14
Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki
Physiological symptoms of mood disturbances, such as fatigue or anxiety, are closely related to inflammation in the central nervous system or the whole body. Curcuma longa is widely used as a dietary spice and has been reported to have anti-inflammatory activity. To investigate the effect of a water extract of C. longa (WEC) on emotional states, a randomized, double-blind, placebo-controlled, parallel-group study was conducted with healthy participants. Forty-eight participants were randomly assigned to receive five tablets containing 150 mg WEC and 0...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29629345/comparative-effects-of-curcumin-and-tetrahydrocurcumin-on-dextran-sulfate-sodium-induced-colitis-and-inflammatory-signaling-in-mice
#15
Joon-Yeop Yang, Xiancai Zhong, Su-Jung Kim, Do-Hee Kim, Hyun Soo Kim, Jeong-Sang Lee, Hye-Won Yum, Jeewoo Lee, Hye-Kyung Na, Young-Joon Surh
Background: Curcumin, a yellow ingredient of turmeric ( Curcuma longa Linn, Zingiberaceae), has long been used in traditional folk medicine in the management of inflammatory disorders. Although curcumin has been reported to inhibit experimentally-induced colitis and carcinogenesis, the underlying molecular mechanisms remain largely unresolved. Methods: Murine colitis was induced by dextran sulfate sodium (DSS) which mimics inflammatory bowel disease. Curcumin or tetrahydrocurcumin was given orally (0...
March 2018: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29629341/role-of-curcumin-in-disease-prevention-and-treatment
#16
REVIEW
Arshad Husain Rahmani, Mohammed A Alsahli, Salah M Aly, Masood A Khan, Yousef H Aldebasi
Treatment based on traditional medicine is very popular in developing world due to inexpensive properties. Nowadays, several types of preparations based on medicinal plants at different dose have been extensively recognized in the diseases prevention and treatment. In this vista, latest findings support the effect of Curcuma longa and its chief constituents curcumin in a broad range of diseases cure via modulation of physiological and biochemical process. In addition, various studies based on animal mode and clinical trials showed that curcumin does not cause any adverse complications on liver and kidney function and it is safe at high dose...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29621898/curcumin-and-its-synthetic-analogue-dimethoxycurcumin-differentially-modulates-antioxidant-status-of-normal-human-peripheral-blood-mononuclear-cells
#17
Emmanuel Simon, P Aswini, V B Sameer Kumar, Gokuldas Mankadath
Curcumin is a polyphenol derived from the herb Curcuma longa, which has been extensively studied in terms of its antitumour, antioxidant, and chemopreventive activity as well as various other effects. In the present work we compared curcumin with its synthetic analogue dimethoxycurcumin (dimc) in terms of its antioxidant enzyme-modulating effects in human peripheral blood mononuclear cells (PBMC). We found that these compounds modulate antioxidant enzymes differentially. Both curcumin and dimethoxycurcumin effected a decrease in lipid peroxidation status in PBMC, however, curcumin had better activity in this regard...
April 6, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29621160/therapeutic-potential-and-recent-advances-of-curcumin-in-the-treatment-of-aging-associated-diseases
#18
REVIEW
Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Heidi Abrahamse
Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric ( Curcuma longa ) plant. Curcumin has been demonstrated as an effective therapeutic agent in traditional medicine for the treatment and prevention of different diseases. It has also shown a wide range of biological and pharmacological effects in drug delivery, and has actively been used for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis, neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes, hypertension, chronic kidney diseases, chronic inflammation and infection...
April 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29618440/synergistic-potential-of-zingiber-officinale-and-curcuma-longa-to-ameliorate-diabetic-dyslipidemia
#19
Naveed Hussain, Abu-Saeed Hashmi, Muhammad Wasim, Tauqeer Akhtar, Shagufta Saeed, Toheed Ahmad
To find the cure of world's one of the leading morbid and mortal disorders; diabetes mellitus and its most prevalent complication, 'diabetic-dyslipidemia', is one of the leading health challenges of 21st century. The use of phytomedicine is a glimmer of hope in this scenario. Studies of current decade have shown that methanolic extracts of Zingiber officinale and Curcuma longa have highly effective therapeutic potentials against the aforesaid disorders, however, which of the extracts has more potential is still unclear...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29607625/turmeric-tonic-as-a-treatment-in-scalp-psoriasis-a-randomized-placebo-control-clinical-trial
#20
Parichehr Bahraini, Mehdi Rajabi, Parvin Mansouri, Golnaz Sarafian, Reza Chalangari, Zahra Azizian
BACKGROUND: Psoriasis is an autoimmune and recurrent chronic inflammatory skin disorder with a strong genetic basis. The characteristic features are hyperproliferation of keratinocytes, leading to redness, thickening, and scaling of the epidermis followed by itching and the appearance of lesions, which in most cases can affect the patients both medically and psychologically. The scalp is one of the most common sites for psoriasis. This condition is predominantly managed with steroids, which are associated with various side effects...
April 1, 2018: Journal of Cosmetic Dermatology
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