keyword
https://read.qxmd.com/read/38411510/case-322-pyothorax-associated-lymphoma
#21
JOURNAL ARTICLE
Jiun-Yiing Hu, Kyung Hee Lee, Gabin Yun
An 81-year-old man living in South Korea was referred to the pulmonology clinic because of abnormal findings at routine surveillance CT. His past medical history included right radical nephroureterectomy for ureteral cancer in 2016, transurethral resection of a bladder tumor in 2015, and tuberculous pleurisy in his third decade of life that was complicated by a chronic calcified empyema. He had been doing well clinically until 6 months prior, when he presented to an outside hospital with progressive right-sided chest pain and dyspnea and was found to have active tuberculosis...
February 2024: Radiology
https://read.qxmd.com/read/38403809/cumulative-incidence-of-and-risk-factors-for-bcg-infection-after-adjuvant-bcg-instillations
#22
JOURNAL ARTICLE
Lars Holmberg, Sten Skogmar, Hans Garmo, Oskar Hagberg, Christel Häggström, Truls Gårdmark, Viveka Ströck, Firas Aljabery, Staffan Jahnson, Abolfazl Hosseini, Tomas Jerlström, Amir Sherif, Karin Söderkvist, Anders Ullén, Per-Uno Malmström, Fredrik Liedberg
OBJECTIVES: To investigate the cumulative incidence proportion of disseminated or local Bacillus Calmette-Guérin (BCG) infections after adjuvant BCG instillations in patients with non-muscle-invasive bladder cancer (NMIBC). PATIENTS AND METHODS: We analysed the timing and occurrence of BCG infections and absolute and relative risk in relation to patient characteristics available in the Swedish nationwide database 'BladderBaSe 2.0'. The cumulative incidence proportion of a BCG infection was indicated by a reported diagnosis of tuberculosis (TB) in the patient registry or filing a prescription for tuberculostatic drugs...
February 25, 2024: BJU International
https://read.qxmd.com/read/38401940/rational-tuning-of-binding-properties-of-pillar-5-arene-based-sensing-material-by-synergistic-effect-and-its-application-for-fluorescent-turn-on-detection-of-isoniazid-and-controlled-reversible-morphology
#23
JOURNAL ARTICLE
Jian-Peng Hu, Qi Zhao, Qi Lin, Hong Yao, You-Ming Zhang, Tai-Bao Wei
Isoniazid (INH) is crucial in the treatment of tuberculosis; however, its overuse may induce significant gastrointestinal and hepatic side effects. On October 27, 2017, the International Agency for Research on Cancer, under the auspices of the World Health Organization, published a list of carcinogens for preliminary collation and reference. Isoniazid was categorized as a Group 3 carcinogen. The efficient detection of INH poses an important and challenging task. In this study, a "synergistic effect" is incorporated into the pillar (Yamagishi and Ogoshi, 2018) [5] arene-based macrocyclic host (DPA) by strategically attaching bis-p-hydroxybenzoic acid groups to the opposite ends of the pillar (Yamagishi and Ogoshi, 2018) [5] arene...
April 1, 2024: Analytica Chimica Acta
https://read.qxmd.com/read/38399270/a-review-of-the-potential-of-poly-lactide-co-glycolide-nanoparticles-as-a-delivery-system-for-an-active-antimycobacterial-compound-7-methyljuglone
#24
REVIEW
Bianca Diedericks, Anna-Mari Kok, Vusani Mandiwana, Namrita Lall
7-Methyljuglone (7-MJ) is a pure compound isolated from the roots of Euclea natalensis A. DC., a shrub indigenous to South Africa. It exhibits significant promise as a potential treatment for the highly communicable disease tuberculosis (TB), owing to its effective antimycobacterial activity against Mycobacterium tuberculosis . Despite its potential therapeutic benefits, 7-MJ has demonstrated in vitro cytotoxicity against various cancerous and non-cancerous cell lines, raising concerns about its safety for consumption by TB patients...
February 1, 2024: Pharmaceutics
https://read.qxmd.com/read/38393913/vaccines-and-dementia-part-ii-efficacy-of-bcg-and-other-vaccines-against-dementia
#25
REVIEW
Charles L Greenblatt, Richard Lathe
 There is growing awareness that infections may contribute to the development of senile dementia including Alzheimer's disease (AD), and that immunopotentiation is therefore a legitimate target in the management of diseases of the elderly including AD. In Part I of this work, we provided a historical and molecular background to how vaccines, adjuvants, and their component molecules can elicit broad-spectrum protective effects against diverse agents, culminating in the development of the tuberculosis vaccine strain Bacille Calmette-Guérin (BCG) as a treatment for some types of cancer as well as a prophylactic against infections of the elderly such as pneumonia...
February 19, 2024: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/38385694/discovery-of-two-novel-immunoepitopes-and-development-of-peptide-based-sarcoidosis-immunoassay
#26
JOURNAL ARTICLE
Changya Peng, Jaya Talreja, Brennen Steinbauer, Kazuhiko Shinki, Laura L Koth, Lobelia Samavati
RATIONALE: Sarcoidosis is a systemic granulomatous disorder associated with hypergammaglobulinemia and the presence of autoantibodies. The specific antigens initiating granulomatous inflammation in sarcoidosis are unknown and there is no specific test available to diagnose sarcoidosis. To discover novel sarcoidosis antigens, we developed a high-throughput T7 phage display library derived from the sarcoidosis cDNA and identified numerous clones differentiating sarcoidosis from other respiratory diseases...
February 22, 2024: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/38371511/pathological-manifestations-of-granulomatous-lobular-mastitis
#27
REVIEW
Leyin Cui, Chenping Sun, Jierong Guo, Xuliu Zhang, Sheng Liu
Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM is often misdiagnosed as breast cancer due to the lack of specificity in clinical and imaging examinations, and therefore histopathology is the main basis for confirming the diagnosis. This review provides an overview of the pathological features of granulomatous lobular mastitis and cystic neutrophil granulomatous mastitis (CNGM, a pathologic subtype of GLM)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38363237/a-systematic-review-and-meta-analysis-of-intraarterial-chemotherapy-for-non-muscle-invasive-bladder-cancer-promising-alternative-therapy-in-high-tuberculosis-burden-countries
#28
JOURNAL ARTICLE
Zakaria Aulia Rahman, Furqan Hidayatullah, Jasmine Lim, Lukman Hakim
INTRODUCTION: Local therapies for high risk non-muscle-invasive bladder cancer (NMIBC) such as intravesical chemotherapy (IVC) have shown a high rate of progression and recurrence (1). Intravesical Bacillus Calmette-Guérin (BCG) for local therapies has been shown to reduce progression and recurrence in patient with NMIBC. However, its potential role is limited in high burden countries for tuberculosis (TB) due to its low specificity that can cause wrong diagnosis or false positive in patients with clinically diagnosed tuberculosis...
February 16, 2024: Archivio Italiano di Urologia, Andrologia
https://read.qxmd.com/read/38357899/early-experience-of-endobronchial-ultrasound-guided-transbronchial-nodal-cryobiopsy-a-case-series-from-sabah-malaysia
#29
JOURNAL ARTICLE
Hema Yamini Ramarmuty, Nai-Chien Huan, Larry Ellee Nyanti, Teng Shin Khoo, Tamilarasi Renganathan, Ahmad Zaki Manoh, Nusaibah Azman, Kunji Kannan Sivaraman Kannan
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is an established minimally invasive method for the diagnosis of benign and malignant conditions. Continuous efforts are underway to improve the material adequacy of EBUS-TBNA, including the introduction of a new technique called EBUS-guided transbronchial nodal cryobiopsy (EBUS-TBNC). This method allows for the retrieval of larger and well-preserved histologic samples from the mediastinum. We present a case series of four patients who underwent combined EBUS-TBNA and EBUS-TBNC procedures in our centre...
2024: Therapeutic Advances in Respiratory Disease
https://read.qxmd.com/read/38357196/redetermination-of-pd-l1-expression-after-chemio-radiation-in-locally-advanced-pdl1-negative-nsclc-patients-retrospective-multicentric-analysis
#30
JOURNAL ARTICLE
Patrizia Ciammella, Salvatore Cozzi, Paolo Borghetti, Marco Galaverni, Valerio Nardone, Maria Paola Ruggieri, Matteo Sepulcri, Vieri Scotti, Alessio Bruni, Francesca Zanelli, Roberto Piro, Elena Tagliavini, Andrea Botti, Federico Iori, Emanuele Alì, Chiara Bennati, Marcello Tiseo
BACKGROUND: Chemoradiation therapy (CRT) is the treatment of choice for locally advanced non-small cell lung cancer (LA-NSCLC). Several clinical trials that combine programmed cell death 1 (PD1) axis inhibitors with radiotherapy are in development for patients with LA-NSCLC. However, the effect of CRT on tumor cells programmed cell death ligand-1 (PD-L1) expression is unknown. METHODS: In this multicentric retrospective study, we analyzed paired NSCLC specimens that had been obtained pre- and post-CRT...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38352666/communicable-and-non-communicable-diseases-diagnosis-and-treatment-service-availability-at-primary-health-care-units-during-covid-19-outbreak-in-ethiopia
#31
JOURNAL ARTICLE
Tajebew Zayede Gonete, Netsanet Abera Asseffa, Kassahun Dessie Gashu, Binyam Tilahun, Dessies Abebaw Angaw, Meskerem Jisso, Alemu Tamiso, Akalewold Alemayehu, Rekiku Fikre, Biru Abdisa, Habtamu Sime, Elias Ali Yesuf, Abdurezak Umer, Mesfin Kebede, Hussen Mohammed, Bekele Yazie, Kassu Ketema Gurmu, Berhanu Fikadie Endehabtu
BACKGROUND: Non-communicable diseases (NCDs) pose a substantial global health challenge, resulting in an annual death toll of over 15 million individuals aged 30 to 69. Ethiopia, categorized as COVID-19 vulnerable, grapples with NCD treatment challenges. This study aims to assess disease service availability at primary health units in Ethiopia during the pandemic. METHODS: A facility-based cross-sectional study was conducted from October to December 2021 across regions, encompassing 452 facilities: 92 health centers, 16 primary hospitals, 344 health posts, and 43 districts...
October 2023: Ethiopian Journal of Health Sciences
https://read.qxmd.com/read/38352160/isolated-prostate-tuberculosis-a-rare-condition
#32
Omar Bellouki, Abdelmounim Boughaleb, Ilyas Soufiani, Imad Boualaoui, Hachem El Sayegh, Yassine Nouini
Tuberculosis remains a global health threat, notably with a considerable burden of extrapulmonary cases. Prostate tuberculosis stands out as a rare and challenging diagnosis, often resulting in substantial management delays. In this report, we present the case of a 55-year-old man in whom initial suspicion of prostate cancer resulted in the diagnosis of prostate tuberculosis. The diagnostic methods, progressive features, and therapeutic tools of this rare condition are discussed.
March 2024: Urology Case Reports
https://read.qxmd.com/read/38351896/clinical-immunological-and-genetic-description-of-a-mexican-cohort-of-patients-with-dock8-deficiency
#33
JOURNAL ARTICLE
Eduardo Liquidano-Perez, Gibert Maza-Ramos, Bethy Alexandra Perez Arias, Saul Oswaldo Lugo Reyes, Tania Barragan Arevalo, Sara Alejandra Solorzano-Morales, Edna Venegas Montoya, Aidé Tamara Staines-Boone, Rogelio Guzmán Cotaya, Satoshi Okada, Capucine Picard, Etienne Patin, Nideshda Ramirez-Uribe, Juan Carlos Bustamante-Ogando, Selma Cecilia Scheffler-Mendoza, Marco Antonio Yamazaki-Nakashimada, Marimar Saez-de-Ocariz, Sara Elva Espinosa Padilla, Maria Edith Gonzalez-Serrano
PURPOSE: We aimed to describe the clinical, immunological, and genetic features of patients with DOCK8 deficiency (DOCK8-Def) in a tertiary care center for children. METHODS: Retrospective chart review of patients' clinical, immunological, and genetic characteristics with DOCK8-Def. Genetic analysis was performed with targeted- or whole-exome sequencing; we also assessed DOCK8 protein expression and a lymphoproliferation assay and analyzed survival by the Kaplan-Meier method...
February 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38346046/provider-and-female-client-economic-costs-of-integrated-sexual-and-reproductive-health-and-hiv-services-in-zimbabwe
#34
JOURNAL ARTICLE
Collin Mangenah, Euphemia L Sibanda, Galven Maringwa, Justice Sithole, Stephano Gudukeya, Owen Mugurungi, Karin Hatzold, Fern Terris-Prestholt, Hendramoorthy Maheswaran, Harsha Thirumurthy, Frances M Cowan
A retrospective facility-based costing study was undertaken to estimate the comparative cost per visit of five integrated sexual and reproductive health and HIV (human immuno-deficiency virus) services (provider perspective) within five clinic sites. These five clinics were part of four service delivery models: Non-governmental-organisation (NGO) directly managed model (Chitungwiza and New Africa House sites), NGO partner managed site (Mutare site), private-public-partnership (PPP) model (Chitungwiza Profam Clinic), and NGO directly managed outreach (operating from New Africa House site...
2024: PloS One
https://read.qxmd.com/read/38341933/interactions-of-deprotonated-phenylalanine-with-gold-clusters-theoretical-study-with-prospects-for-amino-acid-detection
#35
JOURNAL ARTICLE
Andrey A Buglak, Alexei I Kononov
Nanomaterials are widely used nowadays in industry and medicine. The specific properties of gold nanoclusters (Au NCs) are chemical stability, low cytotoxicity, low photobleaching, high sensitivity to the molecular environment. This set of properties allows to use Au NCs as nanosensors in bioimaging and diagnostics. We have investigated gold cluster complexes with proteinogenic amino acid phenylalanine (Phe). Detection of phenylalanine is essential for diagnostics of phenylketonuria, vitiligo, sclerosis, cancer, tuberculosis, etc...
February 8, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38322189/endobronchial-ultrasound-guided-transbronchial-mediastinal-cryobiopsy-a-narrative-review
#36
REVIEW
Hema Yamini Ramarmuty, Masahide Oki
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive, safe, and well-established method for diagnosing and staging lung cancer and other conditions associated with mediastinal lymphadenopathy. Efforts have been made to enhance the material adequacy of EBUS-TBNA, including the recent introduction of EBUS-guided transbronchial mediastinal cryobiopsy (EBUS-TMC). This advancement facilitates the acquisition of larger and better-preserved tissue samples from the mediastinum...
2024: Mediastinum
https://read.qxmd.com/read/38321626/contralateral-pulmonary-resection-after-pneumonectomy
#37
JOURNAL ARTICLE
Ga Hee Jeong, Yong Soo Choi, Yeong Jeong Jeon, Junghee Lee, Seong Yong Park, Jong Ho Cho, Hong Kwan Kim, Jhingook Kim, Young Mog Shim
BACKGROUND: Contralateral pulmonary resection after pneumonectomy presents considerable challenges, and few reports in the literature have described this procedure. METHODS: We retrospectively reviewed the medical records of all patients who underwent contralateral lung resection following pneumonectomy for any reason at our institution between November 1994 and December 2020. RESULTS: Thirteen patients (9 men and 4 women) were included in this study...
February 7, 2024: Journal of chest surgery
https://read.qxmd.com/read/38318361/heat-killed-mycobacterium-tuberculosis-induces-trained-immunity-in%C3%A2-vitro-and-in%C3%A2-vivo-administered-systemically-or-intranasally
#38
JOURNAL ARTICLE
Luna Minute, Marta Bergón-Gutiérrez, Pablo Mata-Martínez, Jaime Fernández-Pascual, Verónica Terrón, Laura Bravo-Robles, Gülce Bıçakcıoğlu, Gabriela Zapata-Fernández, Nacho Aguiló, Eduardo López-Collazo, Carlos Del Fresno
Trained immunity (TI) represents a memory-like process of innate immune cells. TI can be initiated with various compounds such as fungal β-glucan or the tuberculosis vaccine, Bacillus Calmette-Guérin. Nevertheless, considering the clinical applications of harnessing TI against infections and cancer, there is a growing need for new, simple, and easy-to-use TI inducers. Here, we demonstrate that heat-killed Mycobacterium tuberculosis (HK Mtb ) induces TI both in vitro and in vivo . In human monocytes, this effect represents a truly trained process, as HK Mtb confers boosted inflammatory responses against various heterologous challenges, such as lipopolysaccharide (Toll-like receptor [TLR] 4 ligand) and R848 (TLR7/8 ligand)...
February 16, 2024: IScience
https://read.qxmd.com/read/38313926/a-systematic-review-of-artificial-intelligence-applications-in-the-management-of-lung-disorders
#39
REVIEW
Akbar Hussain, Stanley Marlowe, Muhammad Ali, Edilfavia Uy, Huzefa Bhopalwala, Dedeepya Gullapalli, Avinash Vangara, Moeez Haroon, Aelia Akbar, Jonathan Piercy
This systematic review examines the transformative impact of artificial intelligence (AI) in managing lung disorders through a comprehensive analysis of articles spanning 2014 to 2023. Evaluating AI's multifaceted roles in radiological imaging, disease burden prediction, detection, diagnosis, and molecular mechanisms, this review presents a critical synthesis of key insights from select articles. The findings underscore AI's significant strides in bolstering diagnostic accuracy, interpreting radiological imaging, predicting disease burdens, and deepening the understanding of tuberculosis (TB), chronic obstructive pulmonary disease (COPD), silicosis, pneumoconiosis, and lung fibrosis...
January 2024: Curēus
https://read.qxmd.com/read/38309968/-annual-progress-in-tobacco-medicine-in-2023
#40
REVIEW
Z Liu, D Xiao
Smoking is one of the major risk factors for several chronic non-infectious diseases, including chronic respiratory diseases, cancers, cardiovascular diseases, and diabetes, which has become a major public health issue in China. Tobacco control is proven to be the most effective and cost-effective strategy to reduce the risk of smoking-related disease and premature death. From October 2022 to September 2023, several high quality studies on tobacco medicine have been published. This review systematically summarizes the representative studies in terms of epidemiological study, clinical study, mechanism study, and tobacco control progress...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
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