Lola P Camino, Arijit Dutta, Sonia Barroso, Carmen Pérez-Calero, Jeffrey N Katz, María García-Rubio, Patrick Sung, Belén Gómez-González, Andrés Aguilera
R-loops, which consist of a DNA-RNA hybrid and a displaced DNA strand, are known to threaten genome integrity. To counteract this, different mechanisms suppress R-loop accumulation by either preventing the hybridization of RNA with the DNA template (RNA biogenesis factors), unwinding the hybrid (DNA-RNA helicases), or degrading the RNA moiety of the R-loop (type H ribonucleases [RNases H]). Thus far, RNases H are the only nucleases known to cleave DNA-RNA hybrids. Now, we show that the RNase DICER also resolves R-loops...
October 19, 2023: Molecular Cell