keyword
https://read.qxmd.com/read/38494773/-exploration-of-the-method-and-efficacy-of-treatments-for-intractable-pelvic-pain-caused-by-rectal-or-bladder-fistula
#21
JOURNAL ARTICLE
Y M Zhang, G C Wang, Y J Liu, Y C Wang, G Q Zhang, Y Zhang, C Q Gao, C Wang, Z Zhang, J Yang, L Jin, Y P Wang, Z L Niu
Objective: To explore the causes and therapeutic effects of pelvic pain caused by rectal fistula or bladder fistula after comprehensive treatment of cervical cancer and rectal cancer (radiotherapy, surgery, chemotherapy, and other treatments). Methods: A retrospective analysis was conducted on the clinical and pathological data of patients with pelvic tumors admitted to the First People's Hospital of Yinchuan City, Ningxia and the Affiliated Cancer Hospital of Zhengzhou University from June 2016 to June 2022...
March 23, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38494565/leg-lymphoedema-after-inguinal-and-ilio-inguinal-lymphadenectomy-for-melanoma-results-from-a-prospective-randomised-trial
#22
JOURNAL ARTICLE
T S Lee, I Li, B Peric, R P M Saw, J P Duprat, E Bertolli, J B Spillane, B L van Leeuwen, M Moncrieff, A Sommariva, C P Allan, J H W de Wilt, R Pritchard- Jones, J L C Geh, J R Howle, A J Spillane
BACKGROUND: The Evaluation of Groin Lymphadenectomy Extent for Melanoma (EAGLE FM) study sought to address the question of whether to perform inguinal (IL) or ilio-inguinal lymphadenectomy (I-IL) for patients with inguinal nodal metastatic melanoma who have no clinical or imaging evidence of pelvic disease. Primary outcome measure was disease-free survival at 5 years, and secondary endpoints included lymphoedema. METHODS: EAGLE FM was designed to recruit 634 patients but closed with 88 patients randomised because of slow recruitment and changes in melanoma management...
March 17, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38494562/jeffrey-a-norton-and-the-multiple-endocrine-neoplasia-syndromes
#23
EDITORIAL
Samuel A Wells
BACKGROUND: Jeffrey A. Norton could have been a professional football player but instead he chose to pursue a career in medicine and in the process became an outstanding academic surgeon. This story recounts his ascent from a small town in Massachusetts to the pinnacle of academic surgery. METHODS: After graduating from high school in Albany, New York, Jeff continued his education at Dartmouth University, the State University of New York Upstate Medical University at Syracuse (SUNY Upstate Medical University), and the Department of Surgery at the Duke University School of Medicine...
March 17, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38494399/the-use-of-a-high-flow-picc-catheter-for-stem-cell-and-lymphocyte-apheresis-the-initial-experience-of-a-pediatric-oncology-center-in-brazil
#24
JOURNAL ARTICLE
Vilani Kremer, Andréia Rheinheimer, Ana Luiza Rodrigues, Andressa Taborda, Robson Coelho, Antonella Zanette
BACKGROUND: Autologous hematopoietic stem cell transplant (HSCT), characterized by high intensity chemotherapy followed by the infusion of HSC previously collected from the peripheral blood, is a procedure used in the treatment of several malignancies. In pediatrics, the apheresis procedure represents a challenge, due to the need for insertion of a rigid central venous catheter (CVC) in small children. The CVC is usually used for stem cell collection and then removed. Later, the patient will need a new device for cell infusion...
February 24, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38494360/immunocyte-profiling-changes-in-patients-received-epidural-versus-intravenous-analgesia-after-pancreatectomy-a-randomized-controlled-trial
#25
JOURNAL ARTICLE
Chun-Yu Wu, Ting-Chun Kuo, Han-Wei Lin, Jen-Ting Yang, Wen-Hsiu Chen, Wen-Fang Cheng, Yu-Wen Tien, Kuang-Cheng Chan
BACKGROUND: Perioperative immunosuppressants, such as surgical stress and opioid use may downregulate anti-cancer immunocytes for patients undergoing pancreatectomy. Thoracic epidural analgesia (TEA) may attenuate these negative effects and provide better anti-cancer immunocyte profile change than intravenous analgesia using opioid. METHODS: We randomly assigned 108 adult patients undergoing pancreatectomy to receive one of two 72-h postoperative analgesia protocols: one was TEA, and the other was intravenous patient-controlled analgesia (IV-PCA)...
March 16, 2024: Journal of the Formosan Medical Association
https://read.qxmd.com/read/38493899/clonoscreen3d-a-novel-three-dimensional-clonogenic-screening-platform-for-identification-of-radiosensitizers-for-glioblastoma
#26
JOURNAL ARTICLE
Mark R Jackson, Amanda R Richards, Abdul-Basit Ayoola Oladipupo, Sandeep K Chahal, Seamus Caragher, Anthony J Chalmers, Natividad Gomez-Roman
PURPOSE: Glioblastoma (GBM) is a lethal brain tumor. Standard of care treatment comprising surgery, radiation and chemotherapy results in median survival rates of 12-15 months. Molecular targeted agents identified using conventional two-dimensional (2D) in vitro models of GBM have failed to improve outcome in patients, rendering such models inadequate for therapeutic target identification. A previously developed 3D GBM in vitro model that recapitulates key GBM clinical features and responses to molecular therapies was investigated for utility for screening novel radiation-drug combinations using gold-standard clonogenic survival as readout...
March 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38492813/outcome-after-modern-proton-beam-therapy-in-childhood-craniopharyngioma-results-of-the-prospective-registry-study-kiproreg
#27
JOURNAL ARTICLE
M Bischoff, D Ahmad Khalil, S Frisch, C M Bäcker, S Peters, C Friedrich, S Tippelt, R-D Kortmann, B Bison, H L Müller, B Timmermann
BACKGROUND: Craniopharyngiomas (CPs) are rare tumours of the sellar region often leading to significant comorbidities due to their close proximity to critical structures. Aim of this study was to analyse survival outcome and late toxicities after surgery and proton beam therapy (PBT) in childhood CPs. PATIENTS AND METHODS: Within the prospective XXXX study (XXXX), data of 74 childhood patients with CP, receiving PBT between 08/2013-06/2022 were eligible. Late toxicities were analysed according to the grading system of CTCAE 4...
March 14, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38492526/oncological-outcomes-of-intraperitoneal-chemotherapy-in-advanced-ovarian-cancer-brca-mutation-role
#28
JOURNAL ARTICLE
Pablo Padilla-Iserte, Maria Iváñez, Juan Carlos Muruzabal, Rafael Navarro, Berta Díaz-Feijoo, Sara Iacoponi, Virginia García-Pineda, Cristina Díaz, Jesús Utrilla-Layna, Antonio Gil-Moreno, Anna Serra, Juan Gilabert-Estellés, Cristina Martínez Canto, Álvaro Tejerizo, Víctor Lago, José Miguel Cárdenas-Rebollo, Santiago Domingo
INTRODUCTION: The knowledge of BRCA status offers a chance to evaluate the role of the intraperitoneal route in patients selected by biomolecular profiles after primary cytoreduction surgery in advanced ovarian cancer. MATERIALS AND METHODS: We performed a retrospective, multicenter study to assess oncological outcomes depending on adjuvant treatment (intraperitoneal [IP] vs intravenous [IV]) and BRCA status (BRCA1/2 mutated vs. BRCA wild type [WT]). The primary endpoint was to determine progression-free survival...
March 9, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492474/fertility-potential-and-safety-assessment-of-residual-ovarian-cortex-in-young-women-diagnosed-with-epithelial-borderline-and-early-stage-malignant-ovarian-tumors
#29
JOURNAL ARTICLE
L Cacciottola, A Camboni, E Gatti, E Marbaix, M Vignali, J Donnez, M M Dolmans
OBJECTIVE: To establish the safety and quality of ovarian cortex surrounding epithelial ovarian tumors in women eligible for fertility-sparing surgery by identifying occult malignant lesions and characterizing the ovarian follicle pool. METHODS: Multicentric retrospective study of 48 subjects (15-45 years), diagnosed with borderline ovarian tumors (BOTs) or early-stage epithelial ovarian cancers (EOCs) and eligible for fertility-sparing surgery. Histological samples of ovarian cortex surrounding tumors were analyzed to characterize the follicle pool, find any occult malignant lesion using tumor-specific markers (cytokeratin 7 and mucin 1), and quantify tumor-infiltrating lymphocytes (TILs) by CD3 and tumor associated macrophages (TAMs) by CD68...
March 15, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38492275/regoma-oss-a-large-italian-multicenter-prospective-observational-study-evaluating-the-efficacy-and-safety-of-regorafenib-in-patients-with-recurrent-glioblastoma
#30
JOURNAL ARTICLE
M Caccese, I Desideri, V Villani, M Simonelli, M Buglione, S Chiesa, E Franceschi, P Gaviani, I Stasi, C Caserta, S Brugnara, I Lolli, E Bennicelli, P Bini, A S Cuccu, S Scoccianti, M Padovan, S Gori, A Bonetti, P Giordano, A Pellerino, F Gregucci, N Riva, S Cinieri, V Internò, M Santoni, G Pernice, C Dealis, L Stievano, F Paiar, G Magni, G L De Salvo, V Zagonel, G Lombardi
BACKGROUND: In the randomized phase II REGOMA trial, regorafenib showed promising activity in patients with recurrent glioblastoma. We conducted a large, multicenter, prospective, observational study to confirm the REGOMA data in a real-world setting. PATIENTS AND METHODS: The major inclusion criteria were histologically confirmed diagnosis of glioblastoma according to the World Health Organization (WHO) 2016 classification and relapse after radiotherapy with concurrent/adjuvant temozolomide treatment, good performance status [Eastern Cooperative Oncology Group performance status (ECOG PS 0-1)] and good liver function...
March 15, 2024: ESMO Open
https://read.qxmd.com/read/38492259/oncologic-safety-of-breast-conserving-surgery-after-neoadjuvant-chemotherapy-in-patients-with-multiple-ipsilateral-breast-cancer-a-retrospective-multi-institutional-cohort-study
#31
JOURNAL ARTICLE
Élise Di Lena, Stephanie M Wong, Ericka Iny, Sarah Mashal, Mark Basik, Jean-François Boileau, Karyne Martel, Miranda Addie Bassel, Sarkis Meterissian, Ipshita Prakash
INTRODUCTION: The recent ACOSOG Z11102 trial demonstrated low recurrence rates with breast conserving surgery (BCS) in women with multiple ipsilateral breast cancers (MIBC). Questions remain regarding the oncologic safety of BCS in women with MIBC receiving neoadjuvant chemotherapy (NAC). METHODS: We conducted a retrospective cohort study of adult patients who underwent BCS following NAC for stage I-III breast cancer from 2012 to 2021 at two academic centers...
March 12, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38492066/salivary-gland-type-cancers-cross-organ-demographics-of-a-rare-cancer
#32
JOURNAL ARTICLE
Aika Tanzawa, Kengo Saito, Masayuki Ota, Koji Takahashi, Izumi Ohno, Toyoyuki Hanazawa, Katsuhiro Uzawa, Yuichi Takiguchi
BACKGROUND: Salivary gland-type cancers (SGTCs) are histologically heterogeneous and can affect organs other than the salivary glands. Some tumors outside the salivary glands are diagnosed on their unique histological characteristics. Comprehensive cross-organ studies on SGTCs are limited. METHODS: We retrospectively analyzed the data of patients with salivary duct carcinoma (SDC), adenoid cystic carcinoma (AdCC), mucoepidermoid carcinoma (MEC), epithelial-myoepithelial carcinoma (EMC), acinic cell carcinoma (AcCC), and polymorphous adenocarcinoma (PAC) who visited our institution between 2009 and 2019...
March 16, 2024: International Journal of Clinical Oncology
https://read.qxmd.com/read/38492057/defining-the-learning-curve-for-robotic-pancreaticoduodenectomy-for-a-single-surgeon-following-experience-with-laparoscopic-pancreaticoduodenectomy
#33
JOURNAL ARTICLE
Isabel DeLaura, Jeremy Sharib, John M Creasy, Samuel I Berchuck, Dan G Blazer, Michael E Lidsky, Kevin N Shah, Sabino Zani
Robotic pancreaticoduodenectomy (RPD) has a learning curve of approximately 30-250 cases to reach proficiency. The learning curve for laparoscopic pancreaticoduodenectomy (LPD) at Duke University was previously defined as 50 cases. This study describes the RPD learning curve for a single surgeon following experience with LPD. LPD and RPD were retrospectively analyzed. Continuous pathologic and perioperative metrics were compared and learning curve were defined with respect to operative time using CUSUM analysis...
March 16, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38492016/excluding-external-iliac-node-irradiation-during-neoadjuvant-radiotherapy-decreases-lower-intestinal-toxicity-without-compromising-efficacy-in-t4b-rectal-cancer-patients-with-tumours-involving-the-anterior-structures
#34
JOURNAL ARTICLE
Anchuan Li, Miaobin Mao, Runfan Chen, Pan Chi, Ying Huang, Junxin Wu, Benhua Xu
PURPOSE: To explore the impact of excluding the external iliac node (EIN) from the clinical target volume (CTV) during preoperative radiotherapy in T4b rectal cancer with anterior structure invasion. METHODS: We retrospectively identified 132 patients with T4b rectal cancer involving the anterior structures who received radiotherapy followed by surgery between May 2010 and June 2019. Twenty-nine patients received EIN irradiation (EIN group), and 103 did not (NEIN group)...
March 16, 2024: Discover. Oncology
https://read.qxmd.com/read/38491738/engaging-patients-in-designing-a-transmural-allied-health-pathway-a-qualitative-exploration-of-hospital-to-home-transitions
#35
JOURNAL ARTICLE
Juul W M van Grootel, Romain J Collet, Mel E Major, Suzanne Wiertsema, Hanneke van Dongen, Marike van der Leeden, Edwin Geleijn, Raymond Ostelo, Marike van der Schaaf
INTRODUCTION: The transition from hospital to home is often suboptimal, resulting in patients not receiving the necessary allied healthcare after discharge. This may, in turn, lead to delayed recovery, a higher number of readmissions, more emergency department visits and an increase in mortality and healthcare costs. This study aimed to gain insight into patients' experiences, perceptions, and needs regarding hospital-to-home transition, focusing on allied healthcare as a first step towards the development of a transitional integrated allied healthcare pathway for patients with complex care needs after hospital discharge...
April 2024: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://read.qxmd.com/read/38491445/equity-in-the-recovery-of-elective-and-oncological-surgery-volumes-after-the-covid-19-lockdown-a-multicentre-cohort-study-in-italy
#36
JOURNAL ARTICLE
Chiara Di Girolamo, Roberta Onorati, Tania Landriscina, Roberto Gnavi, Giulia Cesaroni, Enrico Calandrini, Lucia Bisceglia, Caterina Fanizza, Teresa Spadea
BACKGROUND: The COVID-19 pandemic has had, and still has, a profound impact on national health systems, altering trajectories of care and exacerbating existing inequalities in health. Postponement of surgeries and cancellation of elective surgical procedures have been reported worldwide. In Italy, the lock-down measures following the COVID-19 pandemic caused cancellations of surgical procedures and important backlogs; little is known about potential social inequalities in the recovery process that occurred during the post-lockdown period...
March 15, 2024: International Journal for Equity in Health
https://read.qxmd.com/read/38491404/radiation-therapy-for-retroperitoneal-sarcoma-practice-patterns-in-north-america
#37
JOURNAL ARTICLE
Samantha M Ruff, Victor Heh, David J Konieczkowski, Amblessed Onuma, Hayley M Dunlop, Alex C Kim, Valerie P Grignol, Carlo M Contreras, Timothy M Pawlik, Raphael Pollock, Joal D Beane
BACKGROUND: The addition of radiation therapy (RT) to surgery in retroperitoneal sarcoma (RPS) remains controversial. We examined practice patterns in the use of RT for patients with RPS over time in a large, national cohort. METHODS: Patients in the National Cancer Database (2004-2017) who underwent resection of RPS were included. Trends over time for proportions were calculated using contingency tables with Cochran-Armitage Trend test. RESULTS: Of 7,485 patients who underwent resection, 1,821 (24...
March 16, 2024: Radiation Oncology
https://read.qxmd.com/read/38491312/retrospective-evaluation-of-the-prognostic-value-of-histological-growth-pattern-in-patients-with-colorectal-peritoneal-metastases-undergoing-curative-intent-cytoreductive-surgery
#38
JOURNAL ARTICLE
Leonel Kamdem, Antoine El Asmar, Pieter Demetter, Ismael Coulibaly Zana, Charif Khaled, Francesco Sclafani, Vincent Donckier, Peter Vermeulen, Gabriel Liberale
BACKGROUND: Two distinct histological growth patterns (HGPs) were described in patients with peritoneal metastasis of colorectal cancer origin (PMCRC) with limited Peritoneal Cancer Index (PCI) ≤ 6 who did not receive neoadjuvant chemotherapy (NAC) and were treated with cytoreductive surgery (CRS) ± hyperthermic intraperitoneal chemotherapy (HIPEC): pushing HGP (P-HGP) and infiltrating HGP (I-HGP). Patients with dominant P-HGP (> 50%) had significantly better disease-free survival (DFS) and overall survival (OS)...
March 15, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38490885/robotic-assisted-pediatric-thoracic-and-abdominal-tumor-resection-an-initial-multi-center-review
#39
JOURNAL ARTICLE
Wendy Jo Svetanoff, Michela Carter, Karen A Diefenbach, Marc Michalsky, Daniel DaJusta, Edward Gong, Timothy B Lautz, Jennifer H Aldrink
INTRODUCTION: Robotic-assisted minimally invasive surgery (RA-MIS) for tumor resection is an emerging technology in the pediatric population with significant promise but unproven safety and feasibility. METHODS: A multi-center retrospective review of patients ≤18 years undergoing RA-MIS tumor resection from December 2015-March 2023 was performed. Patient demographics, perioperative variables, and complication rates were analyzed. RESULTS: Thirty-nine procedures were performed on 38 patients (17 thoracic, 22 abdominal); 37% female and 68% non-Hispanic White...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38490882/incidence-and-risk-factors-for-chyle-leaks-after-neuroblastic-tumor-resection-a-systematic-review-of-published-studies
#40
REVIEW
Arimatias Raitio, Paul D Losty
BACKGROUND: Chyle leakage/ascites after surgical resection of neuroblastic tumors may delay the start of chemotherapy and worsen prognosis. Previous studies have reported a highly variable incidence and risk factors remain largely unknown. This study aims to analyze the true incidence of chyle leaks and ascites and seeks to identify risk factors and optimal treatment strategies. METHODS: Medline/Embase databases were searched according to PRISMA guidelines. Literature reviews, case reports, and non-English papers were excluded...
February 26, 2024: Journal of Pediatric Surgery
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